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REFERAT
HIPERBILIRUBINEMIA
Disusun oleh:
Fiki Setiawan 1102012086
Pembimbing:
dr. Pulung M Silalahi Sp. A
KEPANITERAAN KLINIK ILMU KESEHATAN ANAK
RUMAH SAKIT BHAYANGKARA TK I RADEN SAID SUKANT!
FAKULTAS KED!KTERAN UNI"ERSITAS YARSI
1
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KATA PENGANTAR
Puji serta syukur kita ucapkan kepada Allah SW atas selesainya re!erat
yang "erjudul #iper"iliru"ine$ia. %epada dr. Pulung M Silalahi SP.A selaku d&sen
pe$"i$"ing' saya juga ucapkan teri$a kasih "anyak atas "i$"ingannya sela$a
kepaniteraan ka$i di (agian )l$u %esehatan Anak *.S (hayangkara ingkat )
*aden Said Sukant&.
+ala$ re!erat ini ka$i akan $enc&"a $e$"ahas $engenai
#iper"iliru"ine$ia. Se$&ga pe$"ahasan ka$i ini dapat $e$"antu $e$"uka
wawasan dan pengetahuan "agi $ahasiswa klinik ataupun d&kter u$u$
$engenai #iper"iliru"ine$ia.
Penulis'
,akarta' ,uni 2016
2
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DAFTAR ISI
KATA PENGANTAR...............................................................................................2
DAFTAR ISI............................................................................................................3
BAB I
LATAR BELAKANG..............................................................................................4
BAB II
TINJAUAN PUSTAKA.............................................................................................
2.2 ETIOLOGI....................................................................................................7
2.3 METABOLISME BILIRUBIN.....................................................................8
2.4 HIPERBILIRUBINEMIA...........................................................................11
2.5 PENYEBAB IKTERUS..............................................................................15
2.6 KLASIFIKASI............................................................................................17
2.7 MANIFESTASI KLINIS.............................................................................18
2.8 TATALAKSANA........................................................................................19
2.9 TRANFUSI TUKAR...................................................................................24
BAB III
KESIMPULAN......................................................................................................26
DAFTAR PUSTAKA.............................................................................................27
-
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BAB I
PENDAHULUAN
1.1. L!" B#$%&'
T(# )*"$+ H#$!( R#,*"! 2--8 #&'!%& /(0 AKB + I&+* #&,
2-1--- %#$("& (+, SDKI 2--72--8. B#""! #!, !#"+,! 1- / /" $("
#&&''$: #!, (" + 246 / #&&''$ +& #!, !(& + 89.77- / /"
$(" &' #&&''$. K#!& / $(" #/#" 79; !#"+ #!, &'' ,#"!
%#$("& !#"! ,+ ! ,#"$&&. S#/&% 54; !#"+ ,+ !&'%!& %#$"'
&' #/'& /#" +#//%& !+% #,#"*$#( $&& "%& +& %"&'&
,#&'#!(& %#$"' %& %#'0!+""!& ,+ /. P#// ! %#!& /
/" $(" +$( ,"#!"!: BBLR: 5 '+L +#/! +#&'& (,#"/$"/.
H,#"/$"/ & &*"$: (& 1-; &' /#",*!#& #&+ ,!*$*'
# 2 '+ ! > 2- ;
+" BST.
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H,#"/$"/ ++#
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2.1. D#
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G/" 2.1 %+" #" /$"/& N*"*'" B(!&
2.2. E!*$*'
P#// %!#" ,+ / $(" +,! /#"+" #&+" !,& +,! +#//%& *$#(
/#/#",
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$& $( +#
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& !+% $"! +$ " +& %#+& %& +!"&,*"!%& %# #$ (#,". B$"/& &'
!#"%! ,+ $/& /#"
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B$"/& &' !% !#"%*&' +%*C#"%& %# /#&!% /$"/& %*&' &' $"!
+$ " +"#!%$ #&+*,$ +#&'& /&!& # uridine diphospate glucoronosyl
transferase UDPGT. B$"/& & %#+& +#%%"%& %# +$ %&$%$ #,#+.
S#+&'% ! *$#%$ /$"/& &' !% !#"%*&' %& %#/$ %# "#!%$
#&+*,$!% &!% "#%*&' /#"%!&.
S#!#$( #&'$ ,"*# %*&': /$"/& %& +#%%"#%& %# +$ %&+&'
#,#+: %#+& #% $"& #"& +& +#%"#%& #$$
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/$&: +& / &' #&+#%! %, /$&. N#*&!$ (,#"/$"/ !#"+ %"#&
,#&'%!& ,"*+% ! ,#&"&& clearance /$"/& +& $#/( #"&' !#"+ ,+ /
!".
H,#"/$"/ &' '&
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P#&%! (#*$!% ! ,#&&'%!& %##,!& +#!"% #$ +"( #",%&
,#// ! +" ,#/#&!%& /$"/& &' /#"$#/(&. I%!#" &' !/$
#"&' +#/! %!#" (#*$!%. K*&' +& !"&
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H,#"/$" !% !#"%*&' &' "&'& 12:91-- $ &' $
!#"+ ,+ (" %# + , %#$ #!#$( $(" +#/! %!#"
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+%/!%& *$#( (,#"/$"/ !#"%*&' /& $#/( %&&'
+/&+&'% +#&'& (,#"/$"/ !% !#"%*&'.,#"/(& 0"& /#"%"
+" %&&' &'' + ! , %&&' ( /$ !#"+ */!"% !*!$
$"& #,#+ ,#"/(& & #",%& /%! +& %!#" %*$#!!%: &'
#",%& & $& +" %!#" */!"%!
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$"& ,#"&&: #(&'' %& ++,!%& ,#&&'%!& %+" "*/$&*'#& ++$
!&.
P#&'%!& %+" /$"/& +,! +#//%& *$#( ?
1. K#$&& ,+ #$ +"( #"(2. I% #,#"! $": #,
3. T*%& &' /#"$ +" $" !/( #,#"! */! */!&: ,& &' /#"$ +"
+$ !/( #,#"! &' !#"+ ,+ "#% !"&
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(#,!% ,/$ ,#&/!& !#"+ + &!" (#,!*! +& +%! %*$#+%!: +&
#%!"(#,!% /$ /!& !#"+ ++$ +%! %*$#+%!.
2.6. %$
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D#"! (,#"/$"/ #&"! %"#"
2.7. &
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&' +!&+ *$#( +#,* ,'#& /$"/& ,+ /#/#", +#"( + *!% !#"! +
'&''$ /$:,*&: +& #"#/#$. M&
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. I&*'$*/$& &!"C#& !#$( +'&%& ,+ / / +#&'& "(# &' /#"!
+& &%*,!/$! ABO &!% #%& (#*$ *& +& #"&%& !&+%&
!"&
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S&"
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,#"%& !/( &' !#",,". I&!#&! &' +/#"%& #&!%& #
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#&&'%!& /$"/& &+"#% ,+ . P##/#"& +#&'& %+" $%!*
"#&+( %& #&'"&' !/$& +"#.
3. T/$& %#$&& %$! &' #"&' +#/!flea ite rash++#"( %: /+&
+& #%!"#!. K#$&& & #'#" ($&' #!#$( !#", +(#&!%&. P+
/#/#", / +$,*"%& ,$ %#&'%&& !#"+ /"*#& // &+"*#. H$
& !#"+ %"#& !/( !+% , #&'#$"%& +#&'& #'#" ($ !#",
&". P#/(& 0"& %$! &' /#"
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&!/*+ !#"&$ +" "%$ /. S#(&'' #'( (#*$ $#/( $&! +&
#,#"/% .
1. I&+% !"&
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BAB III
KESIMPULAN
P+ / /" $(" !#"! ,+ / +#&'& /#"! /+& $(" "#&+( ! /
,"#!" #&'$ %!#" ,+ &'' ,#"! %#(+,&. D" +! #,+#*$*' /(0
5-; / /" $(" #&+#"! %!#" +,! ++#!#% ,+ &'' ,#"! %#(+,&.
I%!#" +$( 0"& %$!: %* +& %$#" #&+ %&' %"#& ,#&&'%!& %+"
/$"/& +"( #&&'%!. I%!#" +,! #&+
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DAFTAR PUSTAKA
1. B% A" N#*&!*$*' I%!& D*%!#" A&% I&+* E+ P#"! 2--8: FKUI ?
J%"!
2. P"#: S$C M. )$*& L*"". P!*