1

Smart Data enabling Personalized Digital Health: Deriving Value via harnessing Volume, Variety and Velocity

Amit P. Sheth, Kno.e.sis, Wright State University

2

A Historical Perspective on Collecting Health Observations

Diseases treated onlyby external observations

First peek beyond justexternal observations

Information overload!

Doctors relied only on external

observations

Stethoscope was the first

instrument to go beyond just external

observations

Though the stethoscope has survived, it is only one among

many observations in modern medicine

http://en.wikipedia.org/wiki/Timeline_of_medicine_and_medical_technology

2600 BC ~1815 Today

Imhotep

Laennec’s stethoscope

Image Credit: British Museum

The Patient of the FutureMIT Technology Review, 2012

http://www.technologyreview.com/featuredstory/426968/the-patient-of-the-future/

3

Big Data in Medicine: Implications

“We should not make the mistake of seeing data as a technical issue. It’s a synthesis problem. That’s because information is not

the scarce resource. Attention is.”-- Conrad Wai, The data addiction | The Ideas Economy

4http://www.davidscaduto.com/post/9048831674/we-should-not-make-the-mistake-of-seeing-data-as

5

Sources of Big Data in Digital Health

Velocity Volume

Variety

Veracity

Image: http://www.dr4ward.com/dr4ward/2013/04/what-is-the-power-of-the-big-data-in-healthcare-infographic.html

6

Future Interoperability Challenges: 360 degree health

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Big Data in Digital Health: Can alerts work?

"According to multiple recent studies, doctors ignore between 49–96% of all CDS alerts that

EMRs give them.”1

"Clinical Decision Support systems link health observations with health knowledge to influence health choices by clinicians for improved health

care".-- Robert Hayward, Centre for Health Evidence

1http://www.fastcodesign.com/1664763/badly-designed-electronic-medical-records-can-kill-you

8

Information Overload leading to Alert Fatigue

Ignoring alerts is not limited to Emergency Rooms but has also crept into EMR alerts commonly referred to as “alert fatigue”

http://health.embs.org/editorial-blog/noise-in-hospital-intensive-care-units-icus/

• What if your data volume gets so large and varied you don't know how to deal with it?

• Do you store all your data?• Do you analyze it all?• How can you find out which data points are really important?

• How can you use it to your best advantage?

9

Questions typically asked on Big Data

http://www.sas.com/big-data/

http://techcrunch.com/2012/10/27/big-data-right-now-five-trendy-open-source-technologies/

Variety of Data Analytics Enablers

10

• Current focus mainly to serve business intelligence and targeted analytics needs, not to serve complex individual and collective human needs (e.g., empower human in health, fitness and well-being; better disaster coordination, smart energy consumption) that is highly personalized/individualized/contextualized– Incorporate real-world complexity: multi-modal and multi-sensory nature

of real-world and human perception– Need deeper understanding of data and its role to information (e.g.,

skew, coverage) – Beyond correlation -> causation :: actionable info, decisions grounded

on insights

• Human involvement and guidance: Leading to actionable information, understanding and insight right in the context of human activities– Bottom-up & Top-down processing: Infusion of models and background

knowledge (data + knowledge + reasoning)

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What is missing?

Contex

tual

InformationSmart Data

Makes SenseActionable or help decision

support/making

13

Smart Data

Smart data makes sense out of Big data

It provides value from harnessing the challenges posed by volume, velocity,

variety and veracity of big data, in-turn providing actionable information and

improve decision making.

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“OF human, BY human and FOR human”

Smart data is focused on the actionable value achieved by human involvement in

data creation, processing and consumption phases for improving

the human experience.

Another perspective on Smart Data

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• Focus on verticals: advertising‚ social media‚ retail‚ financial services‚ telecom‚ and healthcare– Aggregate data, focused on transactions, limited integration (limited complexity), analytics to find (simple) patterns

– Emphasis on technologies to handle volume/scale, and to lesser extent velocity: Hadoop, NoSQL,MPP warehouse ….

– Full faith in the power of data (no hypothesis), bottom up analysis

17

Current Focus on Big Data

“OF human, BY human and FOR human”

Another perspective on Smart Data

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Petabytes of Physical(sensory)-Cyber-Social Data everyday! More on PCS Computing: http://wiki.knoesis.org/index.php/PCS 19

‘OF human’ : Relevant Real-time Data Streams for Human Experience

“OF human, BY human and FOR human”

20

Another perspective on Smart Data

Use of Prior Human-created Knowledge Models

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‘BY human’: Involving Crowd Intelligence in data processing workflows

Crowdsourcing and Domain-expert guided Machine Learning Modeling

“OF human, BY human and FOR human”

Another perspective on Smart Data

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Weather Application

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‘FOR human’ : Improving Human Experience

Detection of events, such as wheezing sound, indoor temperature, humidity, dust, and CO2 level

Weather Application

Asthma Healthcare Application

Action in the Physical World

Close the window at home during day to avoid CO2 inflow, to avoid asthma

attacks at night

Public Health

Personal

Population Level

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Why do we care about Smart Data rather than Big Data?

Smart Data enabling Personalized Digital Health: Deriving Value via harnessing Volume, Variety and Velocity

using semantics and Semantic Web

Put Knoesis Banner

Pramod Anantharam

Amit P. Sheth

Cory Henson

Dr. T.K. Prasad

Contributions by many, but Special Thanks to:

Ohio Center of Excellence in Knowledge-enabled Computing (Kno.e.sis)

Wright State University, USA

Sujan Perera

Delroy Cameron

26

April 6, 2011

http://www.nbcnews.com/id/44599555/#.UmMHMWRDszQ

Mr. Michael Yocabet suffering from type 1 diabetes is recommended a kidney transplant at the University of Pittsburgh Medical Center. The organ donor is his life partner Ms. Christina

Mecannic

27

May 6, 2011

http://www.nbcnews.com/id/44599555/#.UmMHMWRDszQ

The couple leaned about the botched kidney transplant making the situation of Mr. Yocabet much worse! The kidney he got from his wife has infected him with Hepatitis C aggravating his

health issues.

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Life Threatening Implications!

http://www.scientificamerican.com/article.cfm?id=2003-blackout-five-years-later

Mr. Yocabet was a disabled former truck driver and he has diabetes type 1. Treatment for the liver may harm

his kidney even cause organ failure and death!

“Because he’s on anti-rejection drugs, the hepatitis C will be a lot worse in him,” -- Ms. Christina Mecannic

29

Cause of the Problem: Official Investigation

http://www.post-gazette.com/stories/local/breaking/upmc-sued-over-botched-kidney-transplant-315580/ http://www.nbcnews.com/id/44599555/#.UmMHMWRDszQ

• Jan 26: Ms. Mecannic gets her blood work positive for Hepatitis C virus.

• March 29: Second attempt to test for Hepatitis C virus in Ms. Mecannic.

• Several meetings of the transplant team -- they fail to notice the problem. (alert fatigue?)

• April 6: Transplant day!• May 6: Couple learned about botched transplant.

30

"Between 2007 and 2010, the CDC conducted 200 investigations into potential transmission of HIV and hepatitis B and C due to organ

transplants.”

Can we Prevent such life threatening incidents?

http://www.nbcnews.com/id/44599555/#.UmMHMWRDszQ

Over 28,000 organs of all types are transplanted every year in United States alone

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How could Smart Data help?

Value: Healthcare Provider Context

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Clinical Decision Making is Complex!

“Health professionals are required to make decisions with multiple foci (e.g. diagnosis, intervention,

interaction and evaluation), in dynamic contexts, using a diverse knowledge base (including an increasing body of evidence-based literature), with multiple variables

and individuals involved.”http://researchoutput.csu.edu.au/R/?func=dbin-jump-full&object_id=9063&local_base=GEN01-CSU01

33

Stakes are high for both doctors and patients!

http://researchoutput.csu.edu.au/R/?func=dbin-jump-full&object_id=9063&local_base=GEN01-CSU01

34

Multimodal, Multisensory, and Multi-organizational Observations

Population health record

Personal health record

Expert opinion

Clinical research

What is the overall health of the person?What are the vulnerabilities for organ

transplant?

Clinical decision support

http://www.rugeleypower.com/electricity-generation/producing-electricity.php

35

Patient Health Score (diagnostic)Semantic Perception and risk assessment algorithms can transform raw data (hard to comprehend) to abstractions (e.g., Patient Health is 3 on a

scale of 5) that is intuitively understandable and valuable for decision makers.

Having health score for various patients will allow efficient utilization of

a decision maker’s precious attention

Risk assessment model

Semantic Perception

Population health record

Personal health record

Expert opinion

Clinical research

Clinical decision support

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Patient Vulnerability Score (prognostic)The Clinical Decision Support systems such as EMR alert system

in its current state follows the high recall philosophy by reporting every possible alert!

Doctors need actionable information and not a deluge of alerts to make timely and important decisions. Providing a vulnerability score

would facilitate right use of Doctor’s time to investigate further on vulnerabilities.

Risk assessment

modelSemantic

Perception

Population health record

Personal health record

Expert opinion

Clinical research

Clinical decision support

37

Value: Patient Context

How could Smart Data help?

38

3.4 billion people will have smartphones or tablets by 2017

-- Research2Guidance

“Intelligence at the Edges” of Digital Health

http://www.digikey.com/us/en/techzone/energy-harvesting/resources/articles/zigbees-smart-energy-20-profile.html

m-health app market is predicted to reach $26 billion in 2017 -- Research2Guidance

39

Data Overload for Patients/health aficionados

Providing actionable information in a timely manner is crucial to avoid information overload

or fatigue

Sleep dataCommunity dataPersonal

Schedule Activity dataPersonal health

records

40

Optimizing Cost, Benefit, and Preferences

Algorithms on the patient side should consider all the health signals and provide actionable and timely information for informed

decision makingWhat are the reasons for my increasing weight?

What should I consider before I get a kidney transplant?

Semantic Perception

Personalized optimization

Personalized recommendatio

n

Img: http://marloncarvallovillae.blogspot.com/2011_02_01_archive.html http://www.1800timeclocks.com/icon-time-systems/icon-time-upgrades/icon-time-advanced-pack-upgrade-sb100-pro/

Sleep data

Community data

Personal Schedule

Activity data

Personal health records

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Annotation of sensor data

SemanticSensorWeb

SemanticPerceptio

n

Intelligence

at the Edge

Interpretation of sensor data

Efficient execution onresource-constrained devices

1 2 3

3 Primary Issues to be addressed

42

RDF OWL

How are machines supposed to integrate and interpret sensor data?

Semantic Sensor Networks (SSN)

43

W3C Semantic Sensor Network Ontology

Lefort, L., Henson, C., Taylor, K., Barnaghi, P., Compton, M., Corcho, O., Garcia-Castro, R., Graybeal, J., Herzog, A., Janowicz, K., Neuhaus, H., Nikolov, A., and Page, K.: Semantic Sensor Network XG Final Report, W3C Incubator Group Report (2011).

44

W3C Semantic Sensor Network Ontology

Lefort, L., Henson, C., Taylor, K., Barnaghi, P., Compton, M., Corcho, O., Garcia-Castro, R., Graybeal, J., Herzog, A., Janowicz, K., Neuhaus, H., Nikolov, A., and Page, K.: Semantic Sensor Network XG Final Report, W3C Incubator Group Report (2011).

45

W3C Semantic Sensor Network Ontology

Lefort, L., Henson, C., Taylor, K., Barnaghi, P., Compton, M., Corcho, O., Garcia-Castro, R., Graybeal, J., Herzog, A., Janowicz, K., Neuhaus, H., Nikolov, A., and Page, K.: Semantic Sensor Network XG Final Report, W3C Incubator Group Report (2011).

46

Semantic Annotation of SWE

Lefort, L., Henson, C., Taylor, K., Barnaghi, P., Compton, M., Corcho, O., Garcia-Castro, R., Graybeal, J., Herzog, A., Janowicz, K., Neuhaus, H., Nikolov, A., and Page, K.: Semantic Sensor Network XG Final Report, W3C Incubator Group Report (2011).

To gain new insight

in patient care &

early indications of

disease

47

Smart Data in Healthcare

… and do it efficiently and at scale

What if we could automate this sense making ability?

49

50

Making sense of sensor data with

People are good at making sense of sensory input

What can we learn from cognitive models of perception?• The key ingredient is prior knowledge

51

* based on Neisser’s cognitive model of perception

ObserveProperty

PerceiveFeature

Explanation

Discrimination

1

2

Perception Cycle*

Translating low-level signals into high-level knowledge

Focusing attention on those aspects of the environment that provide useful information

Prior Knowledge

52

To enable machine perception,

Semantic Web technology is used to integrate sensor data with prior knowledge on the Web

53

Prior knowledge on the Web

W3C Semantic Sensor Network (SSN)

OntologyBi-partite Graph

54

Prior knowledge on the Web

W3C Semantic Sensor Network (SSN)

OntologyBi-partite Graph

55

ObserveProperty

PerceiveFeature

Explanation1

Translating low-level signals into high-level knowledge

Explanation

Explanation is the act of choosing the objects or events that best account for a set of observations; often referred to as hypothesis building

56

Explanation

Inference to the best explanation• In general, explanation is an

abductive problem; and hard to compute

Finding the sweet spot between abduction and OWL• Simulation of Parsimonious Covering

Theory in OWL-DL (using the single-feature assumption*)

* An explanation must be a single feature which accounts forall observed properties

Explanation is the act of choosing the objects or events that best account for a set of observations; often referred to as hypothesis building

57

Explanation

Explanatory Feature: a feature that explains the set of observed propertiesExplanatoryFeature ≡ ∃ssn:isPropertyOf—.{p1} ⊓ … ⊓ ∃ssn:isPropertyOf—.{pn}

elevated blood pressure

clammy skin

palpitations

Hypertension

Hyperthyroidism

Pulmonary Edema

Observed Property Explanatory Feature

58

Discrimination is the act of finding those properties that, if observed, would help distinguish between multiple explanatory features

ObserveProperty

PerceiveFeature

Explanation

Discrimination2

Focusing attention on those aspects of the environment that provide useful information

Discrimination

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Discrimination

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Universe of observable properties

To determine which possible observations are most informative, find those observable properties that can discriminate between the set of hypotheses.

ExpectedProperties

Not-applicableProperties

Discriminating

Properties

Discrimination

Expected Property: would be explained by every explanatory featureExpectedProperty ≡ ∃ssn:isPropertyOf.{f1} ⊓ … ⊓ ∃ssn:isPropertyOf.{fn}

elevated blood pressure

clammy skin

palpitations

Hypertension

Hyperthyroidism

Pulmonary Edema

Expected Property Explanatory Feature

61

Discrimination

Not Applicable Property: would not be explained by any explanatory featureNotApplicableProperty ≡ ¬∃ssn:isPropertyOf.{f1} ⊓ … ⊓ ¬∃ssn:isPropertyOf.{fn}

elevated blood pressure

clammy skin

palpitations

Hypertension

Hyperthyroidism

Pulmonary Edema

Not Applicable Property

Explanatory Feature

62

Discrimination

Discriminating Property: is neither expected nor not-applicableDiscriminatingProperty ≡ ¬ExpectedProperty ⊓ ¬NotApplicableProperty

elevated blood pressure

clammy skin

palpitations

Hypertension

Hyperthyroidism

Pulmonary Edema

Discriminating Property

Explanatory Feature

63

Resource savings of abstracting sensor data

64

Orders of magnitude resource savings for generating and storing relevant abstractions vs. raw observations.

Relevant abstractions

Raw observations

The Decisions are as Good as the Underlying Coded Knowledge

65

• How do we know whether we have all possible relationships?

• How do we know which relationships are missing?

• How can we efficiently fill the missing relationships?

66

Sujan Perera, Cory Henson, Krishnaprasad Thirunarayan, Amit Sheth, Suhas Nair, 'Semantics Driven Approach for Knowledge Acquisition from EMRs', Special Issue on Data Mining in Bioinformatics, Biomedicine and Healthcare Informatics, Journal of Biomedical and Health Informatics (To Appear)

Knowledge is built by abstracting real world facts, once built it should be

able to explain the real world

Semantics Driven Approach for Knowledge Acquisition from EMRs

Explanation Module

Explained?

Yes

NoHypothesis Filtering

Hypothesis Generation

Hypothesis with High Confidence

D

D D

DD

D

Patient Notes

Semantics Driven Approach for Knowledge Acquisition from EMRs

UMLS

68

1.Annotate the EMR documents with given knowledgebase

2.Find unexplained symptoms3.Generate hypothesis for unexplained symptoms1.All disorders in document becomes candidates

4.Filter out candidate disorder with high confidence1.Get disorders which has relationship with unexplained symptom in given knowledgebase

2.Collect the “neighborhood” of the disorders

3.Get the intersection of “neighborhood” and candidate disorders

The Algorithm

D1

D5

D2

D3

D4

S1

D8

D12

D6

D9 D10

D2D7

D11

D13

D5Candidate DiseaseIs symptom of

rdfs:subClassOf

Candidate Filtering Step

Intuition: “similar disorders manifest similar symptoms”

70

Evaluation

Precision = number of suggested correct relationships

Total number of suggested

= 73.09%

Recall = correct relationships found all correct relationships – known

correct relationships

= 66.67%

If we do not perform the semantic filtering step, the precision would be 30%. High precision is important since it is hard to find domain experts to validate the generated hypothesis.

Through physical monitoring and analysis, our cellphones could act as an early warning system to detect serious health conditions, and provide actionable information canary in a coal mine

kHealth

knowledge-enabled healthcare

71

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kHealth to Manage ADHF (Acute Decompensated Heart Failure)

Qualities-High BP-Increased Weight

Entities-Hypertension-Hypothyroidism

kHealth

Machine Sensors

Personal Input

EMR/PHRComorbidity risk score e.g., Charlson Index

Longitudinal studies of cardiovascular risks

- Find correlations- Validation - domain knowledge - domain expert

Parameterize the model

Risk Assessment Model

Current Observations-Physical-Physiological-History

Risk Score(Actionable Information)

Model CreationValidate correlations

Historical observations of each patient

Risk Score: from Data to Abstraction and Actionable Information

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1http://www.nhlbi.nih.gov/health/health-topics/topics/asthma/2http://www.lung.org/lung-disease/asthma/resources/facts-and-figures/asthma-in-adults.html 3Akinbami et al. (2009). Status of childhood asthma in the United States, 1980–2007. Pediatrics,123(Supplement 3), S131-S145.

25 millio

n

300 millio

n

$50 billio

n

155,000

593,000

People in the U.S. are diagnosed with asthma (7 million are children)1.People suffering from asthma worldwide2.

Spent on asthma alone in a year2

Hospital admissions in 20063

Emergency department visits in 20063

Asthma

Asthma is a multifactorial disease with health signals spanning personal, public health, and population levels.

78

Real-time health signals from personal level (e.g., Wheezometer, NO in breath, accelerometer, microphone), public health (e.g., CDC, Hospital EMR), and population level (e.g., pollen level, CO2) arriving continuously in fine grained samples potentially with missing information and uneven sampling frequencies.

Variety Volume

VeracityVelocity

Value

Can we detect the asthma severity level?Can we characterize asthma control level?What risk factors influence asthma control?What is the contribution of each risk factor?

semantics

Understanding relationships betweenhealth signals and asthma attacksfor providing actionable information

WHY Big Data to Smart Data: Healthcare example

79

Population Level

Personal

Public Health

Variety: Health signals span heterogeneous sourcesVolume: Health signals are fine grainedVelocity: Real-time change in situationsVeracity: Reliability of health signals may be compromised

Value: Can I reduce my asthma attacks at night?

Decision support to doctorsby providing them with

deeper insights into patientasthma care

Asthma: Demonstration of Value

80

Sensordrone – for monitoring environmental air quality

Wheezometer – for monitoringwheezing sounds

Can I reduce my asthma attacks at night?

What are the triggers?

What is the wheezing level?What is the propensity toward asthma?

What is the exposure level over a day?

What is the air quality indoors?

Commute to Work

Personal

Public Health

Population Level

Closing the window at homein the morning and taking analternate route to office may

lead to reduced asthma attacks

Actionable

Information

Asthma: Actionable Information for Asthma Patients

Personal, Public Health, and Population Level Signals for Monitoring Asthma

ICS= inhaled corticosteroid, LABA = inhaled long-acting beta2-agonist, SABA= inhaled short-acting beta2-agonist ; *consider referral to specialist

Asthma Control and Actionable Information

Sensors and their observations for understanding asthma

81

82

Personal Level

Signals

Societal Level

Signals

(Personal Level Signals)

(Personalized Societal Level Signal)

(Societal Level Signals)

Societal Level Signals

Relevant to the Personal

Level

Personal Level Sensors (kHealth**) (EventShop*)

Qualify QuantifyAction

Recommendation

What are the features influencing my asthma?What is the contribution of each of these features?

How controlled is my asthma? (risk score)What will be my action plan to manage asthma?

Storage

Societal Level Sensors

Asthma Early Warning Model (AEWM)

Query AEWM

Verify & augmentdomain knowledge

Recommended Action

Action Justification

Asthma Early Warning Model

*http://www.slideshare.net/jain49/eventshop-120721, ** http://www.youtube.com/watch?v=btnRi64hJp4

83

Population Level

Personal

Wheeze – YesDo you have tightness of chest? –Yes

Observations Physical-Cyber-Social System Health Signal ExtractionHealth Signal Understanding

<Wheezing=Yes, time, location><ChectTightness=Yes, time, location><PollenLevel=Medium, time, location>

<Pollution=Yes, time, location><Activity=High, time, location>

Wheezing

ChectTightness

PollenLevel

Pollution

Activity

Wheezing

ChectTightness

PollenLevel

Pollution

Activity

RiskCategory

<PollenLevel, ChectTightness, Pollution,Activity, Wheezing, RiskCategory><2, 1, 1,3, 1, RiskCategory><2, 1, 1,3, 1, RiskCategory><2, 1, 1,3, 1, RiskCategory><2, 1, 1,3, 1, RiskCategory>

.

.

.

Expert Knowledge

Background Knowledge

tweet reporting pollution level and asthma attacks

Acceleration readings fromon-phone sensors

Sensor and personal observations

Signals from personal, personal spaces, and community spaces

Risk Category assigned by doctors

Qualify

Quantify

Enrich

Outdoor pollen and pollution

Public Health

Health Signal Extraction to Understanding

Well Controlled - continueNot Well Controlled – contact nursePoor Controlled – contact doctor

Personal Health Score and Vulnerability Score

84

At Discharge

Health Score

Non-compliance

Poor economic status

No living assistance

Vulnerability Score

Well Controlled

Low

Well Controlled

Very low

Not Well Controlled

High

Not Well Controlled

Medium

Poor Controlled

Very High

Poor Controlled

High

Estimation of readmission vulnerability based on the personal health score

85

Health Signal Extraction Challenges

Social streams has been used to extract many near real-time events

Twitter provides access to rich signals but is noisy, informal, uncontrolled capitalization,

redundant, and lacks context

We formalize the event extraction from tweets as a sequence labeling problem

How do we know the event phrases and who creates the training set? (manual creation is

ruled out)

Now you know why you’re miserable! Very High Alert for B-ALLERGEN Ragweed I-ALLERGEN pollen. B-FACILITY Oklahoma I-FACILITY Allergy I-FACILITY Clinic says it’s an extreme exposure situation

Idea: Background knowledge used to create the training set e.g., typing information becomes the label

for a concept

86

Health Signal Understanding ChallengesFormalized as a problem of

structure extraction of a Bayesian Network

Find the structure that maximize the scoring function Where k indexes over all

possible graph structures

Ehsan Nazerfard, Bayesian Networks: Structure Learning, Topics in Machine Learning, 2011.

Where n is the number of nodesin the network

Huge exponential search space with n

Different structures may result in the same structure score (I-Map)

We use declarative knowledge to choose between Gi and Gj ,

and to guide the search

Where Xi represents eachobservation

How do we implement machine perception efficiently on aresource-constrained device?

Use of OWL reasoner is resource intensive (especially on resource-constrained devices), in terms of both memory and time

• Runs out of resources with prior knowledge >> 15 nodes

• Asymptotic complexity: O(n3)

87

intelligence at the edge

Approach 1: Send all sensor observations to the cloud for processing

Approach 2: downscale semantic processing so that each device is capable of machine perception

88Henson et al. 'An Efficient Bit Vector Approach to Semantics-based Machine Perception in Resource-Constrained Devices, ISWC 2012.

Efficient execution of machine perception

Use bit vector encodings and their operations to encode prior knowledge and execute semantic reasoning

0101100011010011110010101100011011011010110001101001111001010110001101011000110100111

89

O(n3) < x < O(n4) O(n)

Efficiency Improvement

• Problem size increased from 10’s to 1000’s of nodes• Time reduced from minutes to milliseconds• Complexity growth reduced from polynomial to linear

Evaluation on a mobile device

90

2 Prior knowledge is the key to perceptionUsing SW technologies, machine perception can be formalized and integrated with prior knowledge on the Web

3 Intelligence at the edgeBy downscaling semantic inference, machine

perception can execute efficiently on resource-constrained devices

Semantic Perception for smarter analytics: 3 ideas to takeaway

1 Translate low-level data to high-level knowledgeMachine perception can be used to convert low-level sensory signals into high-level knowledge useful for decision making

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D. Cameron, G. A. Smith, R. Daniulaityte, A. P. Sheth, D. Dave, L. Chen, G. Anand, R. Carlson, K. Z. Watkins, R. Falck. PREDOSE: A Semantic Web Platform for Drug Abuse Epidemiology using Social Media. Journal of Biomedical Informatics. July 2013 (in press)

Kno.e.sis - Ohio Center of Excellence in Knowledge-enabled Computing

CITAR - Center for Interventions Treatment and Addictions Research

http://wiki.knoesis.org/index.php/PREDOSE

PREDOSE: Prescription Drug abuse Online-Surveillance and Epidemiology

Bridging the gap between researcher and policy makers

Early identification of emerging patterns and

trends in abuse

In 2008, there were 14,800 prescription painkiller deaths*

*http://www.cdc.gov/homeandrecreationalsafety/rxbrief/

PREDOSE: Prescription Drug abuse Online-Surveillance and Epidemiology

• Drug Overdose Problem in US• 100 people die everyday from drug overdoses• 36,000 drug overdose deaths in 2008• Close to half were due to prescription drugs Gil Kerlikowske

Director, ONDCP

Launched May 2011

PREDOSE: Bringing Epidemiologists and Computer Scientists together

Early Identification and Detection of

Trends

Access hard-to-reach Populations

Large Data Sample Sizes

Group Therapy: http://www.thefix.com/content/treatment-options-prison90683

Interviews

Online Surveys

Automatic Data Collection

Not Scalable

Manual Effort

Sample Biases

Epidemiologist

Qualitative Coding

Problems

Computer Scientist

Automate Information Extraction & Content

Analysis

I was sent home with 5 x 2 mg Suboxones. I also got a bunch of phenobarbital (I took all 180 mg and it didn't do shit except make me a walking zombie for 2 days). I waited 24 hours after my last 2 mg dose of Suboxone and tried injecting 4 mg of the bupe. It gave me a bad headache, for hours, and I almost vomited. I could feel the bupe working but overall the experience sucked.

Of course, junkie that I am, I decided to repeat the experiment. Today, after waiting 48 hours after my last bunk 4 mg injection, I injected 2 mg. There wasn't really any rush to speak of, but after 5 minutes I started to feel pretty damn good. So I injected another 1 mg. That was about half an hour ago. I feel great now.

Codes Triples (subject-predicate-object)

Suboxone used by injection, negative experience

Suboxone injection-causes-Cephalalgia

Suboxone used by injection, amount Suboxone injection-dosage amount-2mg

Suboxone used by injection, positive experience

Suboxone injection-has_side_effect-Euphoria

experience sucked

feel pretty damn good

didn’t do shit

feel great

Sentiment Extraction

bad headache

+ve

-ve

TriplesDOSAGE PRONOUNINTERVAL Route of

Admin.RELATIONSHIPS SENTIMENTS

DIVERSE DATA TYPESENTITIES

I was sent home with 5 x 2 mg Suboxones. I also got a bunch of phenobarbital (I took all 180 mg and it didn't do shit except make me a walking zombie for 2 days). I waited 24 hours after my last 2 mg dose of Suboxone and tried injecting 4 mg of the bupe. It gave me a bad headache, for hours, and I almost vomited. I could feel the bupe working but overall the experience sucked.

Of course, junkie that I am, I decided to repeat the experiment. Today, after waiting 48 hours after my last bunk 4 mg injection, I injected 2 mg. There wasn't really any rush to speak of, but after 5 minutes I started to feel pretty damn good. So I injected another 1 mg. That was about half an hour ago. I feel great now.

I was sent home with 5 x 2 mg Suboxones. I also got a bunch of phenobarbital (I took all 180 mg and it didn't do shit except make me a walking zombie for 2 days). I waited 24 hours after my last 2 mg dose of Suboxone and tried injecting 4 mg of the bupe. It gave me a bad headache, for hours, and I almost vomited. I could feel the bupe working but overall the experience sucked.

Of course, junkie that I am, I decided to repeat the experiment. Today, after waiting 48 hours after my last bunk 4 mg injection, I injected 2 mg. There wasn't really any rush to speak of, but after 5 minutes I started to feel pretty damn good. So I injected another 1 mg. That was about half an hour ago. I feel great now.

Buprenorphine

subClassOf

bupe

Entity Identification

has_slang_term

SuboxoneSubutexsubClassO

f

bupeyhas_slang_te

rm

Drug Abuse Ontology (DAO) 83 Classes

37 Properties

33:1 Buprenorphine24:1 Loperamide

Ontology Lexicon Lexico-ontology

Rule-based Grammar

ENTITIESTRIPLES

EMOTIONINTENSITYPRONOUN

SENTIMENT

DRUG-FORMROUTE OF

ADMSIDEEFFECT

DOSAGEFREQUENCYINTERVAL

Suboxone, Kratom, Herion, Suboxone-CAUSE-Cephalalgia

disgusted, amazed, irritated

more than, a, few of

I, me, mine, myIm glad, turn out

bad, weird

ointment, tablet, pill, film

smoke, inject, snort, sniff

Itching, blisters, flushing, shaking hands, difficulty

breathing

DOSAGE: <AMT><UNIT> (e.g. 5mg, 2-3 tabs)

FREQ: <AMT><FREQ_IND><PERIOD> (e.g. 5 times a week)

INTERVAL: <PERIOD_IND><PERIOD> (e.g. several years)

PREDOSE: Smarter Data through Shared Context and Data Integration

Data Type

Semantic Web Technique

Limitations of Other Approaches

Entity Ontology-driven Identification & Normalization

ML/NLP IRRequires Labeled Data

Unpredictable term

frequencies

Triple Schema-driven

Difficult to develop language model

Requires entity

disambiguation

Sentiment

Ontology-assisted Target Entity Resolution

Inconsistent data for Parse Trees or rules

Diverse simple & complex

slang terms & phrases

PREDOSE: Role of Semantic Web & Ontologies

99

Loperamide-Withdrawal Discovery

Loperamide is used to self-medicate to from Opioid Withdrawal symptoms

100

Big Data from Healthcare Smart Data for Healthcare

Red, yellow, and green indicate high, medium, and low risk allowing

decision makers to focus on red & yellow variables

Big Data vs. Smart Data in Digital Health (Healthcare provider)

Population health record

Personal health record

Expert opinion

Clinical research

Clinical decision support

What is the overall health of the person?What are the vulnerabilities for organ

transplant?

Ms. Mecannic’s blood test not yet complete

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Red, yellow, and green indicating high, medium,

and low risk factors

Recommendation algorithms will analyze

data deluge with domain knowledge

Big Data vs. Smart Data in Digital Health (Healthcare consumer)

Big Data from Healthcare Smart Data for Healthcare

What are the reasons for my increasing weight?What should I consider before I get a kidney

transplant?

Sleep data

Community data

Personal Schedule

Personal health records

Activity data

101http://www.airtel.in/forme/important-alerts

Ms. Mecannic: Your blood work is

incomplete. Please finish this before

organ donation!

• Real Time Feature Streams: http://www.youtube.com/watch?v=_ews4w_eCpg

• kHealth: http://www.youtube.com/watch?v=btnRi64hJp4

• PREDOSE: https://www.youtube.com/watch?v=gCFPzMgEPQM

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Demos

Take Away

• Data processing for personalized healthcare is lot more than a Big Data processing problem

• It is all about the human – not computing, not device: help them make better decisions, give actionable information– Computing for human experience

• Whatever we do in Smart Data, focus on human-in-the-loop (empowering machine computing!):– Of Human, By Human, For Human– But in serving human needs, there is a lot more than what current big data analytics handle – variety, contextual, personalized, subjective, spanning data and knowledge across P-C-S dimensions

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Acknowledgements• Kno.e.sis team• Funds: NSF, NIH, AFRL, Industry…

• Note:• For images and sources, if not on slides, please see

slide notes• Some images were taken from the Web Search results and

all such images belong to their respective owners, we are grateful to the owners for usefulness of these images in our context.

104

• OpenSource: http://knoesis.org/opensource

• Showcase: http://knoesis.org/showcase

• Vision: http://knoesis.org/node/266

• Publications: http://knoesis.org/library

105

References and Further Readings

Amit Sheth’s

PHD students

Ashutosh Jadhav

Hemant

Purohit

Vinh Nguyen

Lu ChenPavan

Kapanipathi

Pramod Anantharam

Sujan Perera

Alan Smith

Pramod Koneru

Maryam Panahiazar

Sarasi Lalithsena

Cory Henson

Kalpa Gunaratna

Delroy Cameron

Sanjaya Wijerat

ne

Wenbo Wang

Kno.e.sis in 2012 = ~100 researchers (15 faculty, ~50 PhD students)

107

thank you, and please visit us athttp://knoesis.orghttp://knoesis.org/projects/ssw/

http://wiki.knoesis.org/index.php/PCS

Kno.e.sis – Ohio Center of Excellence in Knowledge-enabled ComputingWright State University, Dayton, Ohio, USA

Smart Data