INDUSTRIAL S.A.

POLYMORPHISM IN PROCESS DEVELOPMENT

• X-RAY POWDER DIFFRACTION (XRPD)• DIFFERENTIAL SCANNING CALORIMETRY (DSC)• THERMOGRAVIMETRIC ANALYSIS (TGA)• HOT STAGE MICROSCOPY

EVRYKLEIA G. KARAGIANNIDOURESEARCH SCIENTIST

THESSALONIKI 14-07-2011

POLYMORPHISM is a phenomenon related to the ability of a compound to exist, in the solid state, in

different crystalline forms.

EXAMPLE : Linezolid XRPD

EXAMPLE : Linezolid DSC

Example of LINEZOLID FORM II: Pictures from Hot Stage Microscope

Form II –Linezolid at 30oC Form II –Linezolid at 155oC

Form II –Linezolid at 158oC Form II –Linezolid at 180oC

Example of LINEZOLID FORM I: Pictures from Hot Stage Microscope

Form I –Linezolid at 30oC Form I –Linezolid at 175oC

Form I –Linezolid at 180oCUpon Reheating Something NEW was observed at 60-80oC

THANK YOU VERY MUCH FOR YOUR ATTENTION