Polymorphism in Process Development
10
INDUSTRIAL S.A. POLYMORPHISM IN PROCESS DEVELOPMENT • X-RAY POWDER DIFFRACTION (XRPD) • DIFFERENTIAL SCANNING CALORIMETRY (DSC) • THERMOGRAVIMETRIC ANALYSIS (TGA) • HOT STAGE MICROSCOPY EVRYKLEIA G. KARAGIANNIDOU RESEARCH SCIENTIST THESSALONIKI 14-07-2011
Transcript of Polymorphism in Process Development
INDUSTRIAL S.A.
POLYMORPHISM IN PROCESS DEVELOPMENT
• X-RAY POWDER DIFFRACTION (XRPD)• DIFFERENTIAL SCANNING CALORIMETRY (DSC)• THERMOGRAVIMETRIC ANALYSIS (TGA)• HOT STAGE MICROSCOPY
EVRYKLEIA G. KARAGIANNIDOURESEARCH SCIENTIST
THESSALONIKI 14-07-2011
POLYMORPHISM is a phenomenon related to the ability of a compound to exist, in the solid state, in
different crystalline forms.
EXAMPLE : Linezolid XRPD
EXAMPLE : Linezolid DSC
Example of LINEZOLID FORM II: Pictures from Hot Stage Microscope
Form II –Linezolid at 30oC Form II –Linezolid at 155oC
Form II –Linezolid at 158oC Form II –Linezolid at 180oC
Example of LINEZOLID FORM I: Pictures from Hot Stage Microscope
Form I –Linezolid at 30oC Form I –Linezolid at 175oC
Form I –Linezolid at 180oCUpon Reheating Something NEW was observed at 60-80oC
THANK YOU VERY MUCH FOR YOUR ATTENTION
