Model PAPER

End Semester (1ST Sem.) Examination

Program: B.Pharm

Semester: First Semester

Course: Pharmaceutical Inorganic Chemistry (Theory)

Course Code: BPT104T

Section I (MCQ)

Marks-2 marks

1. Impurities in pharmaceutical preparation may be due to following sources

(a) Raw material

(b) Manufacturing process

(c) Solvent

(d) All of the above

2. _______________ water if free from organic impurities.

(a) Tap water

(b) Demineralized water

(c) Distilled water

(d) None of above

3. One of the following is not a reagent constituent of barium sulphate

(a) Ethanol

(b) K2SO4

(c) BaCl₂

(d) Dil. HCl

4. Ferrous thioglycollate is in acidic solution.

(a) Colourless

(b) Pink

(c) Purple

(d) Yellow

5. ___________ is added in preparation of barium sulphate reagent to prevent super saturation.

(a) Ethanol

(b) K2SO4

(c) BaCl₂

(d) a & b

6. One of following is true for limit test

(a) It semi-quantitative method

(b) Designed to identify small quantities of impurities

(c) Designed to control small quantities of impurities

(d) All of above

7. The arsenic free reagents are designated as

(a) AST

(b) ArR

(c) ArT

(d) None of above

8. Potassium cyanide is used in limit test of

(a) Iron

(b) Lead

(c) Heavy metals

(d) Arsenic

9. Lead-dithizone complex is in color.

(a) Purple

(b) Red

(c) Violet

(d) Green

10. One of the following limit tests is based on comparison of color.

(a) Limit test of sulphate

(b) Limit test of chloride

(c) Limit test of iron

(d) a & c

11. What is the full form of pH?

a) Positive hydrogen

b) Potential Hydrogen

c) Positron

d) Proton of hydrogen

12. Which of the following is an example of amphoteric molecule?

a) Acetic acid

b) Malic acid

c) Sugars

d) Water

13. A solution having a pH of 6 has a proton concentration of _______

a) 10-6 M

b) 106 M

c) 6 M

d) 0.6 M

14. Carbonic acid and bicarbonate ions buffer which of the following?

a) Cytosol

b) Cytoplasm

c) Blood

d) Lymph

15. pH is:

a) Positive logarithm of hydrogen ion concentration

b) Positive logarithm of hydroxide ion concentration

c) Negative logarithm of hydrogen ion concentration

d) Negative logarithm of hydroxide ion concentration

16. Calcium levulinate is used as calcium replenisher, chemically it is

(a) calcium-2-oxo pentanoate dehydrate

(b) calcium-3-oxo pentanoate dehydrate

(c) calcium-4-oxo pentanoate dehydrate

(d) calcium-5-oxo pentanoate dehydrate

17. Hypochloremia can be caused by

(a) salt losing nephritis

(b) metabolic acidosis

(c) both (a) and (b)

(d) metabolic alkalosis

18. Which vitamin is necessary for proper tooth formation?

a. Vitamin A

b. Vitamin D

c. vitamin C

d. All of the above

19. The agents which reduce hypersensitivity of teeth for heat and cold are called

a. Dental Fluorosis

b. Desensitizing agents

c. Anticaries agents

d. none of the above

20. A solution of zinc chloride 1% and zinc sulphate 2% is been used as

a. Astringent mouthwash

b. toothpaste

c. polishing agents

d. whitening agent

21. The goal of antacid therapy.

(a) Concentration of acid in gastric juice

(b) Gastic pH 3.5 and 7

(c) 1 Concentration of acid

(d) Both (a) and (b)

22. Symptoms of achlohydria.

a) Mild diarrhoea

b) Frequent bowel movement

c) Epigastric pain

d) All of the above

23. Side effect of antacid therapy.

(a) Acid rebound

(b) Systemic allealopsis

(c) Na content of antacid

(d) All of the above

24. Al(OH)3 gel is used in

(a) dentrifices

(b) radioactivite agent

(c) raptic ulcan

(d) all of the above

25. Calcium contaning antacid differ from aluminium containing antacid

(a) depend upon their basic property

(b) do not have any amphoteric effect

(c) do not cause systemic alkalosis

(d) all of the above

26. Side effect of Ca containing antacid.

(a) Renal failure

(b) Mille allkali syndromes

(c) Hyperphosphatemia

(d) All of the above

27. Stimulant laxative act by

(a) local irritation of intestinal trad

(b) 1 bulk stimulating peristalsis

(c) omatic load

(d) all of the above

28. Expectorant are used in treatment of respiratory tract by

(a) ↑ viscosity of bronchial sec

(b) viscosity of bronchial sec

(c) t amount of refractory tract fluid a demulcent action is extract

(d) both (b) and (c)

29. Ammonium chloride is used as

(a) expectorant

(b) diuretic

(c) systemic acidifier

(d) all of the above

30. The acid neutralizing capacity of an antacid plane at least

(a) 5 meq. of HCI per dosage unit

(b) 7 meq. of HCI per dosage unit

(c) 8 meq. of HCI per dosage unit

(c) 10 meq. of HCI per dosage unit

31. Antimony Postassium tartrate is

a) emetic

b) expectorant

c) antidote

d) a and b

32. NH₂ Cl is used as

(a) Systemic acidifier

(b) Electrolyte replenisher, when chloride is needed but sodium is not indicated

(c) Expectorant

(d) All of above

33. Molecular formula of Blue vitriol is.

(a) CuSO4.5H₂ O

(b) COSO. 5H₂ 0

(c) FeSO4.5H₂ 0

(d) Na₂ SO4.5H₂ O

34. One of the following is not a haematinic

(a) Iron

(b) Folic acid

(c) Vitamin B₁ 2

(d) Vitamin B₂

35. One of the following is an Iron in storage protein

(a) Transferrin.

(b) Ferritin

(c) Cytochrome

(d) None of above

36. Alum is prepared from

(a) Potassium sulphate and aluminum sulphate

(b) Potassium chloride and aluminum sulphate

(c) Potassium sulphate and aluminum chloride

(d) Potassium carbonate and aluminum sulphate

37. One of the following is not true for Sodium thiosulphate

(a) Assay is based on iodimetrc redox titration.

(b) Used as antioxidant

(c) Used as antidote in cyanide poisoning

(d) Molecular formula is Na₂ S30₂ .5H₂ 0

38. What are the product A and B in following reaction

(a) 2Na₂ CO3 +4 NO + 0₂ A and B

(b) 3 NaNO₂ and 2 CO₂

(c) 4 NaNO₂ and 2 CO₂

(d) 2 NaNO₂ and 3 CO₂

(e) 2 NaNO₂ and 2 CO₂

39. One of the following is not used in iron deficiency anaemia

(a) Ferrous Fumarate

(b) Ferrous Gluconate

(c) Ferrous Sulphate

(d) Ferrous succinate

40. One of the following is a protein precipitant.

(a) Activated charcoal

(b) ZnSO4

(c) FeSO4

(d) NaNO₂

41. The amount of material that produces 3.7 x 1010 nuclear decays per second, equivalent to the

activity of 1 g of radium is known as

(a) Roentgen

(b) 1 Curie

(c) 1 Becquerel

(d) 1 RAD

42. 1 Becqurel is equivalent to

(a) 2.7 x 10-11 curie

(b) 2.7 x 10-10 curie

(c) 2.7 x 10-8 curie

(d) 2.7 x 10-5 curie

43. Which of the following has lowest tissue penetration

(a) α-particle

(b) β-particle

(c) x-rays

(d) γ-rays

44. 88Ra226 86Rn222 + ____________

(a) α

(b) β

(c) α + ß

(d) γ

45. Geiger-Muller counter can detect ___________

(a) α and β

(b) ß and γ

(c) α, ß and γ

(d) γ

46. ____________ is used for the measurement of absorption of vitamin B12 in the diagnosis of

pernacious anaemia.

(a) Co 57 and Co 58

(b) Co59 and Co60

(c) Co 58

(d) Co 57

47. The SI unit for absorbed dose is

(a) gray (Gy)

(b) rad

(c) erg

(d) none of the above

48. 1 curie = D.P.S.

(a) 3.7 x 1012

(b) 2.7 x 1010

(c) 3.7 x 1010

(d) 3.7 x 1011

49. One of the following is not true for particle ___________

(a) They are affected by strong magnetic fields

(b) Can penetrate aluminum sheet up to 3 mm thickness.

(c) They have negative charge

(d) All of above

50. (10) _____________ is not an isotope of hydrogen.

(a) 1H¹

(b) 1H²

(c) 1H³

(d) None of above

UNIT-I

GROUP-A

Marks (5)

1. Explain the principle and procedure for the limit test for sulphates.

2. Explain briefly the implications of impurities in pharmaceutical substances.

3. Explain the principle and reaction involved in the heavy metals (IP) limit test.

4. Summarize on Pharmacopoeia of India.

5. Give the principle, reactions involved in the limit test for iron and lead.

GROUP-B

Marks-(10 Marks)

1. Explain the various sources of impurities in pharmaceuticals. Discuss the importance of

Limit tests in quality control of pharmaceuticals.

2. Illustrate impurities? Explain different sources of impurities with examples.

3. Describe the principle, apparatus and procedure for the limit test of arsenic.

4. Define limit test? List out different limit tests you have studied. Discuss in detail the limit

Test for lead and iron.

Unit II

GROUP-A

Marks-(5 marks)

1. What are buffers derive from the Henderson-hasselbalch equation for buffers?

2. Define acids and bases according to various concepts.

3. Write a note on buffer solutions & Isotonic Buffer.

4. Define Isotonic Solutions. How it is measured? Describe various methods used to adjust

isotonicity.

5. Discuss the physiological acid-base balance in the body.

6. Summarize on electrolytes used in replacement therapy.

7. Define desensitizing agents? Give examples. Discuss the role of fluorides in dental caries.

GROUP-B

Marks- (10 marks)

1. Discuss various types of physiological buffers. Explain the mechanism of their Buffer

action.

2. Explain major buffers used in pharmaceutical preparations. What are the disadvantages of

each? What factors must be taken into consideration in the Selection of a buffer?

3. Explain the preparation, assay principle, storage conditions and medical uses of calcium

Gluconate injection.

4. Define dentifrices? Classify them with an example. Write a note on the role of fluoride as

an Anticaries agent.

5. Discuss the role of fluorides in dental caries. Describe the method of preparation and uses

of any two dental products.

Unit III

GROUP-A

Marks-( 5 marks)

1. Define cathartics. Give the preparation and uses of any two cathartics.

2. What are GIT agents? Classify them with examples. Write a note on acidifiers.

3. Describe the various mechanism of action of inorganic anti-microbial agents.

4. Explain the principle, reaction and procedure involved in the assay of chlorinated lime and

hydrogen peroxide.

5. Express the preparation and uses of Chlorinated lime and boric acid.

GROUP-B

Marks-( 10 marks)

1. Enlist in detail any drug with their molecular formula, synonym (if any) method of

preparation and use belongs to magnesium, aluminium and sodium-containing antacid.

2. Explain the principle, reaction and procedure involved in the assay of chlorinated lime and

hydrogen peroxide.

3. Discuss about on antacid combination therapy? Classify antacids with examples. Give the

method of Preparation, uses and assay of Sodium bicarbonate.

4. What are anti-microbial? Give the method of preparation and principle in the assay of

chlorinated lime.

Unit IV

GROUP-A

Marks-(5 marks)

1. Define haematinics? Give the method of preparation, assay principle and Medicinal uses

ferrous sulphate.

2. Give reasons- a) Potassium iodide is used in the assay of Copper sulphate b) HCHO used

in the assay of Ammonium chloride.

3. Explain the method of preparation and assay of Ammonium chloride.

4. What is cyanide toxicity? What the symptoms and treatment are for cyanide Poisoning?

GROUP-B

Marks-(10 marks)

1. Define and classify antidotes with examples. Write a note on activated charcoal.

2. Express the chemical formula, pharmaceutical uses of activated charcoal and sodium

thiosulphate. Explain the principle and reactions involved in the assay of copper sulphate.

3. Define expectorants? Give example and mechanism of action. Give the method of assay

of anyone expectorant.

Unit -V

GROUP-A

Marks – (5 marks)

1. Explain in detail any one method employed for the measurement of radioactivity.

2. Describe the precautions for storage and handling of radioisotopes.

3. What are radiopharmaceuticals? Discuss the importance of radioisotopes used in Medicine.

4. Give a brief account of hazards associated with radiopharmaceuticals.

GROUP-B

Marks-(10 marks)

1. Write the pharmaceutical application radioactive substances. Write a note on

radiopharmaceutical sodium iodide.

2. Explain the diagnostic and therapeutic applications of radioisotopes in Detail.

3. Write the uses of sodium iodide I131. Write a note on radiopharmaceutical sodium iodide I131

4. Give the precautionary measure required to handle radioactive substances. Write the

pharmaceutical application radioactive substances

Prepared By: Subhendu Dey

Disclaimer: - This is a Model Paper. The Question in End semester examination will differ

from the Model Paper. This Model paper is meant for practice only.