HISTOLOGICAL CHANGES ON THE KIDNEY OF THE OFFSPRING FROM MOTHERS TREATED WITH URANYL ACETATE IN...

وزارة التعليم العالي والبحث العلمي كلية العلوم-جامعة بغداد

المجلة العراقية للعلوم

البحوث المقبولة للنشر -عدد خاص في المؤتمر العلمي االول

قسم علوم الحياة

2102\اذار \7-6للفترة من

2102\اذار \7-6 للفترة من/ قسم علوم الحياة/ المؤتمر العلمي األول

242

HISTOLOGICAL CHANGES ON THE KIDNEY OF THE OFFSPRING

FROM MOTHERS TREATED WITH URANYL ACETATE IN ALBINO

RATS.

Sabah N. Alwachi, Nusaibah Amer

[email protected] , [email protected]

Department. of Biology, College of science, University of Baghdad, Iraq. Baghdad-Iraq

Abstract

This study was carried out to investigate the toxicity of the oral administration of

uranyl acetate on kidney. For this purpose, twenty females mature Albino rats which

were divided into four equal groups, control group (G1) administrated distilled

water, and other three groups administrated orally for 70 days (10 weeks), with (50,

75 and 100 mg/kg/b.w. /day of uranyl acetate), for 10 days before mating with

untreated males, as well as during pregnancy (3 weeks) and lactation (5 weeks).

Kidney was taken from the offspring at two stages (3rd

and 5th weeks) ages for the

current study. The exposure of rats to different doses of uranyl acetate caused a

significant (p<0.05) decrease b.w. of the offspring at 3rd

week age, while b.w of the

offspring revealed no significant at the 5th

week age, and also decreased the numbers

of the offspring . The histopathological changes in the kidney of the rat offspring

were revealed variety to the lesions like widening to the proximal convoluted tubule,

distraction to the tubular epithelium, and atrophy to the glomerulus, also widening to

the urinary space, and narrowing of the tubular lumen. Also it was showed hyaline

cast inside the lumen of urinary tubule, was shown with a necrosis of the tubular

epithelium, and vacuolation of the cytoplasm.

رذ األبيضالتغيرات النسجية في كلية األبناء من أمهات معاملة بخالت اليورانيوم في الج

نسيبة عامر ، صباح ناصر العلوجي العراق-بغداد.جامعة بغداد ،كلية العلوم ،قسم علوم الحياة

الخالصة

أجريتته هتتلد اسةرالتتف سن ستتة ختت لتتخيف لتتله اسي راميتت اسخطرتت ا سمخعتت ه تت رريتت اس تت نتت طتت ختت اامتت (Albino rats) ا تتي جتترلا21التتدلة سعتتلا اس تتر . األ ضتت ا اسوي يتتف ستتا جلتت اسخ اسيتتة

سختت ا اسخررتتر يمختت جر تته (G1) جر تته اسخجخ تتف األ ستت , اسم ضتتجف ملتتخه أستت أر طتتف خجتت خي خدلتت يفخن ت س تت تت ختت ل 011, 70, 01اسخجت خي اساللالتتف األلتترر درا يتل خدد سيتتف ختت لتله اسي راميتت خرتتةاره

أيتت م تت اسدتتلا ذ ختت ل تت ر يتتر خجر تتف تتلس 01جر تته اامتت سختتةا ,( ألتت ي 01)يتت 71سختتةا ( اسجلتت طتتتة دستتتريا اسخ اسيتتتة نتتت ختتتروندي س نيتتتفدتتت ألتتتل ا(.ألتتت ي 0) سدتتترا اسرضتتت ف( ألتتت ي 3)أالمتتت ا سدتتترا اسوختتت

ستا (P<0.05) أظعره اسمد ئج وتة امل ت خطمت . س ر أجراا اسةرالف( أل ي 0أل ي 3) خريدي ستا أ لا است اةاه (P<0.05) يمخت ت خطتة اامل ت يتر خطمت , ألت ي 3خطتة أ لا است اةاه طختر

أظعتتره مدتت ئج . تتلس أظعتتره اسمدتت ئج امل تت ستتا تتةة استت اةاه خر رمتتف خجخ تتف اسلتتيررا. ألتت ي 0 طختتر ستا د لت اسم يتل اسخندت استةاما وتة أضترار خدم تف خت , اس وص اسملتجا اسخرضتا سن نيتف سنت اةاه اسم دجتف

خت يمته اسمدت ئج اردست ا خت اة ,ضي دج ي ه ضخ ر سا اس ي ف أةر أس د لت ستا سلتوف خت أةر أس ةالتتتت اسم يتتتتل اس تتتت سا دملتتتتر ستتتتا اسملتتتتج أسرلئتتتتا ستتتته تتتتلس ظعتتتتت ر ( hyaline cast) ستتتت سف د تتتت

.اسل يد لل .اس.سج اه

mailto:[email protected]

mailto:[email protected]


245

Introduction: Soluble uranium and all nano-particles can

cross the placenta, and these are particularly

toxic to the rapidly developing embryo or fetus

[1]. Very high doses of U in drinking water can

affect the development of the fetus in the

laboratory animals [2]. As well, U affects on

postnatal development and behavior of the

offspring [3].

The half-life of U in the kidneys of human has

been estimated to be 1 to 6 days for 99% of the

distributed dose and 1,500 days for the

remainder [4]. In rats, 95% of the dose

distributed to the kidneys is excreted in the urine

within one week [5,6,7]. The half-life of U

compounds in the kidneys has been reported to

be 2 to 17 days in rats [8,9]. In the kidneys, U is

released from bicarbonate and is free to combine

to form complexes with phosphate ligands and

proteins in the tubular wall to cause damage

[10]. Although the regenerated epithelium has

histological differences from its normal state, it

is often difficult to detect histological signs of

kidney damage a month after exposure because

all remaining functional damage is subtle. An

alternative mechanism through which U exerts

its renal toxicity has been suggested by the

results of a study conducted with rabbit kidney

cells in vitro. In some studies, uranyl nitrate

hexahydrate inhibited both sodium transport-

dependent and independent ATP utilization and

mitochondrial oxidative phosphorylation in the

renal proximal tubule [11, 10].

Many animal studies have shown that inhalation,

oral or dermal exposure to U results in kidney

damage. The damage was histological

manifested as glomerular and tubular wall

degeneration. Ultra structural analysis showed

damage to the endothelial cells in the

glomerulus, such as loss of cell processes, and

reduction in the density of the endothelial

fenestrate [12, 13, 14].

Leggett,(1989)(15)and Domingo, (1995) [16]

have been shown that uranyl ion inhibits Na+

transport-dependent and Na+ transport-

dependent ATP utilization, as well as

mitochondrial oxidative phosphorelation in the

renal proximal tubules, at doses not high enough

to destroy a critical mass of kidney cells. The

effect of the uranyl ion appears to be reversible,

as some of the cells which are replaced.

Materials and Methods: Uranyl acetate:

Dissolve powder of uranyl acetate in D.W,

and administrated with 50, 75,100 mg/kg/b.w

[17].

Animals and housing condition: Thirty (10 males and 20 females) sexually

mature laboratory breed males and females

Sprague- Dawley Albino rats (Rattus

norvegicus) of an average body weight of

230±3.565 gm and 12-15 weeks old were

obtained from animal house of the national

center for censorship and curative researches in

Baghdad.

Animals were kept in the Department of

Biology, College of Science, University of

Sulaimania; under the laboratory conditions (12

h light: 12h dark photoperiod), with controlled

room temperature 25-28oc, good ventilation and

were feed normal rodent pellets and tap water ad

Libitum.

Experimental Design:

The rats were randomly divided into four

groups. Each group were kept into box cage

measuring 40×25×15 cm. Female rats were

mated with males (2:1) until copulation was

detected. Finding of sperm indicated copulation

and the day of detection were designated as Day

0 of gestation. Then the adult fertile females

were treated with uranyl acetate dihydrate

(UAD) by gavages 10 days w before mating

with untreated males, as well as during

pregnancy and lactation [18]. The first group

served as a control and only receive drinking

water .However three concentration of uranyl

acetate dissolved in water were administrated

gavages to three other groups of females

(50,75,100 mg/ kg/ B.W/ day)

Dissection and Removal of Organ:

The offspring at the two stage of age (3rd

and

5th

weeks) were killed by cervical dislocation ,

then each group were scarified directly kidney

was taken from the offspring at the two stage of

age (3rd

and 5th

weeks).

Histological preparations Histological examination was done by fixing

the organs of the mice in 10% formalin saline,

processed and embedded in paraffin wax. Tissue

blocks were sectioned 5 µm thick and stained

with Haematoxylin and Eosin. [19].


244

Result: Body weight:

In this study, the b.w. of the offspring at 3rd

week age were significantly decreased compare

with the control , as in (Table 1). While, the b.w.

of the offspring at 5th week age were no

significant different, compare with the control,

as in (Table 1).

Histological changes:

A normal histological structure of the kidney

showed a normal structure of glomerulus with a

normal bowman's capsules and bowman's space,

also showed a normal structure of convoluted

tubules (Fig.1). Section of kidney of offspring at

5th and 3th week (G2) showed widening to the

renal tubule, atrophy to the renal corpuscle and

vaculation to the cells of the renal tubule (Fig. 2)

Section of kidney of offspring at 3rd

week (G3)

necrosis and vaculation to the renal tubular

epithelium, atrophy to the renal corpusels. (Fig.

3).Section of kidney of offspring at 5th week

(G3)Showed necrosis to the renal tubular

epithelium, widening and dilatation to the renal

tubules (Fig. 4). Section of kidney of offspring

at 3rd week (G4) Showed congestion in the

renal blood vessels, slid widening to the urinary

space, and atrophy to the renal corpuscle

(Fig.0).Section of kidney of offspring at 5th

week (G4) Showed increased urinary space and

necrosis to the proximal convoluted tubules (Fig

6) Table 1: B.w of the offspring at (3rd week) age

and B.w of the Offspring at (5th week) age

Treated

with U.A

B.w of the

offspring at

(3rd week)

B.w of the

Offspring at

(5th week ) age

Mean ± SE Mean ± SE

0 mg/Kg 8.400 ±

1.517 a

6.022 ± 1.166

a

50

mg/Kg

5.400 ±

2.074 b

8.464 ± 6.535 a

75

mg/Kg

5.750 ±

0.957 b

5.796 ± 1.181

a

100

mg/Kg

5.000 ±

2.000 b

6.098 ± 3.215

a

Different letters indicate statically significant

differences (P >0.05)

Similar letters indicate statically no significant

differences.

B.W: body weight of offspring

SE: Standard Error

Discussion: In this study, significant weight loss was

noticed in the b.w. of the offspring at 3rd

week

age compared with the control, These results

are consistent with [20] the main reason of this

loss in b.w at this age is totally depending on

mother's milk which contain U.A from exposed

females [21], before that passes across the

placenta during the pregnancy [22]. While, the

b.w. of the offspring at 5th week age were not

significantly different compare with the control,

as in (Table1; Fig.1), because they were feeding

normal rodent pellets in addition of mother's

milk. Therefore, the immune system was in

progress at this stage [23]. The kidney is a

complex organ consisting of well-defined

components that function in a highly

coordinated fashion, when a segment of the

functional unit of the kidney is altered, acute

renal failure (ARF) may occur Tubules are the

most frequently damaged area in ARF [24]


242

Fig.1: Section of kidney of control (G1) showed ( ) normal Bowman's capsule, ( )Normal

convoluted tubules, (100X)

Fig.2:Section of kidney of offspring at 3rd

week (G2) showed ( ) necrosis and distraction to the

renal tubules epithelium,( ) Focal infiltration of the inflammatory cells,( )vaculation to the

cells of the renal tubule,(100X).

Fig.3:Section of kidney of offspring at 3

rd week (G3)Showed ( ) necrosis and vaculation to the

renal tubular epithelium, ( ) atrophy to the renal corpusels, (100X).


246

Fig.4: Section of kidney of offspring at 5th

week (G3) Showed ( ) necrosis to the renal tubular

epithelium, ( ) widening and dilatation to the renal tubules, (100X).

Fig.5: Section of kidney of offspring at 3

rd week (G4) Showed ( ) congestion in the renal blood

vessels, ( ) widening to the urinary space ,( )atrophy to the renal corpuscle,(100X).

Fig 6:Section of kidney of offspring at 5

th week (G4) Showed ( ) necrosis to the convoluted

tubules, ( ) vaculation of the cytoplasm (400X).


247

Section of kidney of offspring at 5th week (G4)

and (G3) Showed increased urinary space and

necrosis to the proximal convoluted tubules also

vaculation of the cytoplasm and necrosis to the

renal tubular epithelium, and widening and

dilatation to the renal tubules, also vaculation to

the renal tubular epithelium. Section of kidney

of offspring at 3rd

week (G4) and (G3) showed

congestion in the renal blood vessels, slid

widening to the urinary space, and atrophy to the

renal corpuscle and necrosis and vaculation to

the renal tubular epithelium, and atrophy to the

renal corpusels that’s agreed with [25] these

lesion translate from mothers to their offspring

cross placenta and during lactating as discussed

later. Section of kidney of offspring at 5th week

(G2) showed necrosis the proximal convoluted

tubular epithelium and focal distraction to the

renal parenchyma, also widening to the renal

tubule, and atrophy to the renal corpuscle and

vaculation to the cells of the renal tubule.

Section of kidney of offspring at 3rd

week (G2)

showed necrosis and distraction to the renal

tubules epithelium focal infiltration of the

inflammatory cells, and vaculation to the cells of

the renal tubule as shown in also, focal

infiltration of the inflammatory cell. Once in the

blood, U is distributed to the organs of the body.

Uranium in body fluids generally exists as the

uranyl ion (UO2)2+ complexes with anions such

as citrate and bicarbonate. Approximately 67%

of U in the blood is filtered in the kidneys and

leaves the body in urine within 24 hours; the

remainder distributes to tissues [20]. The

histopathology damage to the proximal tubules

in G4 and G3 is manifest as cytoplasmic

vacuolation, interstitial scarring, and destruction

of the basal lamina [26]. Histopathology

examinations showed that the UA causes sever

damage in the kidney of rats offspring, similar

results were recorded by [27, 16] who were

attributed that the U caused renal injury in the

experimental animal mostly the damaging of the

proximal convoluted tubules, however, it has

also been found to extend into other regions of

the kidneys, including the corticomedullary

region and the glomerulus [27, 28]. Also atrophy

to the glomerulus and widening to the urinary

space were observed in this study, Sclerosis of

glomerular capsules, reticulum sclerosis of

tubular basement membranes and interstitial

scarring, Dilation, apical displacement, and

vesiculation of tubular nuclei, glomerular

adhesions, focal tubular degranulation and

sloughing the cells into the tubular lumen, these

results were in agreement with previous results

of Gilman et al., (1998)[26].While, there is no

evidence for glomerular injury [29]. A

mechanism involving bicarbonate uptake in the

kidneys and subsequent precipitation of U in the

tubule was proposed for U-induced renal

toxicity [2]. Also, the results were revealed

focally severe necrosis of small lining epithelial

cells of some renal tubules as indicated by

sloughing of cells into the tubular lumens, loss

of nuclei and vaculation of the cytoplasm, were

same as [30] In general, histopathological

sections in G2(treated with 50 mg/kg/b.w)

reveals necrosis the proximal convoluted tubular

epithelium and focal distraction to the renal

parenchyma, also widening to the renal tubule,

atrophy to the renal corpuscle and vaculation to

the cells of the renal tubule. Mechanisms for

decreased glomerular filtration appear to involve

multiple factors including changes in renal

plasma flow, glomerular capillary hydrostatic

pressure, tubular hydraulic pressure, and

glomerular ultrafiltration coefficient. Tubular

impairments include glucosuria, amino aciduria,

enzymuria, and osmotic diuresis. Prominent

features of tubular injury are initial necrosis of

the terminal segments of the proximal tubule

with subsequent involvement of the distal tubule

[30]. Although specific studies on the

nephrotoxic effects of U in children have not

been conducted, it is reasonable to assume that

children would be at increased risk for adverse

effects from exposure compared with adults.

Children consume more water and food per

kilogram of body weight than do adults [31].

Thus, children will ingest proportionately

greater quantities of any contaminants that are

present in the water or food that they consume.

For example, the 3-year-old girl in this case

series who manifested elevated urinary excretion

of beta-2-microglobulin was reported to derive a

major portion of her nutritional intake from

infant formula that was prepared by mixing

powdered formula with contaminated well water

[32]. Alterations causing thickening of the

glomerular basement membrane of the kidney,

which results from the storage of uranium in the

kidney can be prolonged and severe enough to

cause permanent damage [33]. Sclerosis of

glomerular capsules, reticulin sclerosis of

tubular basement membranes and interstitial

scarring, Dilation, apical displacement, and

vesiculation of tubular nuclei, glomerular

adhesions, focal tubular degranulation and


245

sloughing the cells into the tubular lumen, these

results were in agreement with previous

Focally severe necrosis of small lining epithelial

cells of some renal tubules, were same as

Diamond et al., (1989) [30].

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Contents الصفحة االحياء المجهرية علم -اسم البحث ت0 COMPARATIVE STUDY BETWEEN METHICILLIN

RESISTANT AND METHICILLIN SENSITIVE Staphylococcus

epidermidis Estabraq N. Abdul Lateef, May T. Flayyih

0

خطوط في EnterotoxigenicEscherichia coliتأثير الذيفانات المعوية لبكتريا 2 السرطانية خارج الجسم الحيالخاليا م ها ي لة ي لي ، رسية خوج ل اسخصنا ، اسع لطية م

8

3 A STUDY OF SOME IMMUNOLOGICAL AND

HEMATOLOGICAL ASPECTS IN CHILDREN WITH RENAL

DISEASE Eman Abbas Muhsin, Rajwa H. Essa, Sinaa M. Shakir

01

4 THE ROLE OF INTERLEUKIN -6 IN CHRONIC

PERIDONTITIS AND RHEUMATOID ARTHRITIS Batool H. Al-Ghurabei

27

دراسة المحتوى البكتيري للحم الجاموس الهندي المستورد في بعض أسواق بغداد 0 ل سة راس ا راهي ، لج ولي اسر يطا، لةاة لنخ ولي اسط ما، سرر خوخة اال

32

6 BACTERIOLOGICAL AND MOLECULAR IDENTIFICATION

OF Salmonella enterica serovar Typhi IN CLINICALLY

SUSPECTED TYPHOID PATIENTS IN GARMIYAN DISTRICT Bahrouz M. A. Al- Jaff, Hanan T. Subhi

38

7 POSSIBLE ASSOCIATION BETWEEN IL17A & TYPE 1

DIABETES MELLITUS Jaleel Najah, Batool A. Al-Haidary, Laith Abdel-Ellah

00

8 EFFECT OF DIFFERENT ENVIROMENTAL AND

NUTRITIONAL FACTORS ON ALGINATE PRODUCTION

FROM Azotobacter vinellandii A3 Husam S.Auhaim , Shatha Salman Hassan

07

1 DETERMINATION OF THE OPTIMAL GROWTH

CONDITIONS FOR CHOLERA TOXIN PRODUCTION FROM

A LOCAL CLINICAL ISOLATE OF Vibrio cholerae Khlood, A. Al-Khafaji, Amina, N. Al- Thwani

63

01 EXTRACTION AND PURIFICATION OF LECITHINASE

FROM PROTEUSVULGARISAND STUDYSOME CYTOTOXIC

EFFECT ON KIDNEY TISSUE. RasmyiaAbed Abu-Reesha., Zahra Abbas Jabar

72

00 STUDY EFFECT OF NIGELLA SATIVA SEED OIL ON LOCAL

ISOLATE OF METHICILLIN SENSITIVE

STAPHYLOCOCCUS AUREUS (MSSA) AND METHICILLIN

RESISTANCE STAPHYLOCOCCUS AUREUS (MRSA) Rasmyia Abed Abu-risha, Alyaa Rzogy Hussain, Khamael Lutfi Al-taie

83

02 OPTIMUM CONDITIONS FOR β-hydroxybutyrate

PRODUCTION BY Azotobacter chroococcum 9 Suaad Ali Ahmed , Shatha Salman Hassan

88


220

03 ANTIOXIDANT, ANTIBACTERIAL ACTIVITIES AND

PHENOLIC CONTENT OF ETHANOLIC EXTRACT FROM

SOME LABIATAE FAMILY PLANTS. Sanaa Abdulhussein Khraibit, Enas Kareem Abdmadlom, Kais Kassim Ghaima

14

في مدينة اربيل لدى النساء وبائية لمرض السيالن دراسة 04 سرو ضخة خويل ، نا ولي اةويه ، لعينف م س ةار ه

012

00 DETECTION OF HUMAN CYTOMEGALOVIRUS (HCMV)

AMONG ABORTED WOMEN IN AL-NAJAF

GOVERNORATE. Saif Jabbar Yasir , Kareem Thamir Mashkoor, Ghanim Aboud Al-Mola

008

العالقة بين بعض المؤشرات المناعية وشدة الربو األرجي 06 ضو لطة ص سا، ي لر ل ةاس ه ل، خ ر ة اسر ئا

020

07 CLINICAL AND IMMUNOLOGICAL STUDY IN PATIENTS

WITH POST Streptococcus GLOMERULONEPHRITIS Damra Waleed, Maysoon Ahmed, Maissra Samir, Samir Abbed Al abbas, Saad

Muhammad

030

08 THE POTENTIAL AFFECT OF AQUEOUS AND ETHANOL

EXTRACTS OF SOME PLANTS ON SOME PATHOGENIC

BACTERIA Abbas Abdul Kadir Rabat, Intisar Mahmood Juma, Sawsan Mohammed Abdullah

Al-Sorchee

046

01 HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY

PERFORMANCE EVALUATION SAMPLE TESTING RESULT

PROVIDED BY PARTICIPANT LABORATORIES IN THE

IRAQI NATIONAL EXTERNAL QUALITY ASSESSMENT

SCHEME OCTOBER, 2011

Adnan Hadi Jawad , Fatin M.M Shukur, Khdija S. Abdul Wahed

004

21 THE RELATIONSHIP BETWEEN SERUM LEVELS OF

TOTAL IgE, IL-12, IL-13 AND IL-18 IN CHILDREN WITH

ATOPIC DERMATITIS Ghadah M Al-Quraishi, Sami M Al-Timimi, Rashid M Al-Muslih , Jasim,T Al-

Khafaji.

061

B91 Enterococcus لبكتريـاالمحلية تنقية وتوصيف انزيم الجيالتينيز من العزلة 20

faecalis ، لور اروي ولي خمط ليل ل

061

22 STUDY OF USING BITTER MELON (Momordica

charantia) FRUITS EXTRACTS AS ANTIBACTERIAL AND

ANTIDIBETIC AGENTS. Mohammed Ibrahim Nader, Kais Kassim Ghaima, Rami Ali Taqi , Sanaa

Abdulhusain ghraibit

081

23 DESIGNING A NOVEL APPROACH IN THERAPY

OPTIMIZATION FOR SOPHISTICATED DISEASES SUCH AS

AUTOIMMUNE DISEASE (VITILIGO DISEASE) USING

BIOINFORMATICS Mohammed Abdul Rahmman Mohammed

088


222

24 COMPARISON BETWEEN SEVER HAEMOPHILIC A AND

HEALTHY CHILDREN IN STREPTOCOCCUS MUTANS ,

ORAL LACTOBACILLI AND CANDIDA ALBICANS COUNTS. Maha F. Almelan, Zainab A. ALDhaher

017

20 THE ABILITY OF Streptococcus Mutans TO ADHERE AND

BIOFILM FORMATION May Talib Flayyih , Shaymaa Fouad Rasheed

212

26 A STUDY ON SOME VIRULENCE FACTORS OF COAGULASE

NEGATIVE STAPHYLOCOCCI ISOLATED FROM SKIN INFECTION IN

SULAIMANIYA HOSPITALS

May T. Flayyih , Narmeen N. F. Hawramy

200

المنقى جزئيًافي خمج Proteus mirabilis لبكتريا UCAالتأثير الوقائي لخمل 27 المسالك البولية في الفئران

عامر سعيد علي ، مي طالب فليح

220

باستخدام حالة التخمرات Serratia Marcescenaseانتاج انزيم الكايتنيز من بكتريا الـ 28 الصلبة والسائلة ودوره في المعالجة الحيوية

، ميس عماد احمد شذى سلمان حسن

221

في مرضى التهاب الكبد الفايروسي C3 ،C4دور بعض الحركيات الخلوية واجزاء المتمم 21 Cالمزمن نوع

ص ا ة اس ري ة اسرلا ،أخمف مصية ج ل ، ملري س ر خوخ ة

236

31 ROTAVIRUS INFECTION IN INFANTS AND YOUNG

CHILDREN WITH ACUTE GASTROENTERITIS IN

BAGHDAD. Huda Sahib Abdul-Mohammed Al-Rawazq, Mohammed Al-Faham, Mahjoob N. Al-

Nadawi

242

30 A COMPARATIVE STUDY ON THE CYTOTOXIC EFFECT

OF PYOCYANIN PRODUCED BY WILD TYPE AND MUTANT

OF LOCALLY ISOLATED PSEUDOMONAS AERUGINOSA. Hayfa H. Hassani, Adawia Abdulah Al-Saadi, Hussam Mahmood Hasan, Amal

M.Ali, Maeda H. Mohammad

247

الصفحة علم البيئة –أسم البحث ت

32 USE THE SCANNING ELECTRON MICROSCOPY

TECHNIQUES COUPLED WITH ENERGY DISPERSIVE X-

RAY TO DETERMINE THE UPTAKE OF LEAD IN

SCENEDESMUS ACUMINATUS A.S. Dwaish, D.Y. Mohammed, A.M. Jawad , A.A.AL-kubaicy

256

التأثيرات الحادة والمزمنة لمبيد االعشاب جرامكسون في اسماك الكارب االعتيادي 33Cyprinus carpio L. (2010 )

اوخة ج ل خوخة اسطلا ، خوخة خ ر اسرا ، خوخة م س نا اسطلا

260

34 ANALYSIS OF HEAVY METALS CONCENTRATIONS IN

SOIL OF NAHRAWAN BRICKS FACTORIES BY USING

ARCGIS 9.2 Bassim M. Hashim, Inas A. Alwan, Jenan H. Mohamad

270

.العراق,ي لمجتمع الهائمات النباتية في نهر الفرات البيئالتنوع 30 ج ل خوخة لنخ ، سؤاة خمور ن ، ول جخي ج اة اس دل

277


225

36 CHROMIUM POLLUTION AND ITS EFFECT ON ENZYME

ACTIVITY ALP, GPT AND GST AND WHAT IS RELATED

WITH ITS DIFFERENT LIVER DISEASES. Jaefer Hashim Muhsin, Kasim Kadhim Mohammed, Hanan fathel Abbas

294

و ,ALP,GPTبفعالية أنزيمات وعالقته( التلوث بالكروم )التلوث الصناعي تأثير 37 وبعض العناصر الحيويه للجسم األكسدة الفوقية للدهون الخ ا ل ر ، جط ر ه س خول وم س ض س،

298

38 SAPROLEGNIACEAE GENERA ISOLATED FROM

INFECTED COMMON CARP (Cyprinus carpio L .) EGGS AND

FRY IN AL-MANAHEL AND AL-WAHDA FISH

HATCHERIES, IN THE MIDDLE PART OF IRAQ. Al-Shammari, R. H., Habib, K. A. , Al-Mukhtar, E. A.

303

31 THE REMOVAL OF COPPER AND LEAD FROM

INDUSTERIAL WASTE-WATER USING CITRUS PEELS Z.A. Husoon, M.N.A. Al-Azzawi , S.A.K. Al-Hiyaly

309

الفصلية وطول شبكة دراسة شاملة لنوعية مياه الشرب في مدينة بغداد بتأثير العوامل 41 التوزيع

لتتترال خوخة خوخ ة رل ما، أوخة ة اس ه ل اسسيلنا

317

40 THE PREFERENTIAL ABILITY OF SOME SPECIES OF

DOMINANT BACTERIA IN THE BIOSORPTION OF

CHROMIUM FROM THE INDUSTRIAL WASTEWATER Shorouq Saad Shams Al-Deen Wahbi, Muhammad Nafea Ali Al Azzawi

327

42 CHEMICAL COMPOSITION OF SOME FRESHWATER

FISHES FROM IRAQ Amer A. Al-Shamma’a, Muhanned R. Nashaat, Ennas M. Karrem , Lamia A.

Rasheed

336

في ,Liza abu (1843 (Heckel من قبل سمكة الخشني المتناول الغذاء الطبيعي 43 دجلة وسط العراق –ذراع الثرثار قناة

علي عودة شاوردي ،بدر محمد العزاوي ،عامر علي الشماع

341

في أهوار جنوب العراق Leuciscinaeالصفات الحياتية لثالث أنواع من أسماك السمنان 44 ال خر ل س نا ، ةاسرلا خوخ ة خوخة ، س ج ل اس يص

348

40 PREPARATION, CHARACTERIZATION AND BIOACTIVITY

OF NOVEL PHOSPHOROUS CONTAINING SCHIFF BASE

AND ITS TRANSITION METAL COMPLEXES Isam Hussain T. Al-Karkhi , Abeer Khalid Yaseen, Eman Turky Shamkhy, M.

Ibrahim M. Tahir, Karen A. Crouse , Rozita Rosli

358

دراسة التأثيرات والجدوى البيئية إلنشاء مشروع معالجة مخلفات الليف لشجرة النخيل 46 نا أ راهي اسخ ل ، نا ج ه لنخ ، خوخة خمص ر س رس، مجلا س ر ليل

367

47 ISOLATION AND DIAGNOSIS OF HEAVY METAL

RESISTANT PSEUDOMONAS SP. BACTERIA FROM

HOSPITAL WASTE WATER IN MOUSL CITY Lamiaa Finjan Nashi , Sada Jasim

373


224

Brevicoryneدراسة سمية مبيدي ماالثايون ونوكوز على حشرة َمن اللهانـــــة 48

brassicae (L.) ( Homoptera : Aphididae)

ة اسواهمة لعي ،خوخة خ ر اسرا

379

41 استخدام مياه الصرف الصحي في الري لعدة مواسم زراعية وتأثيرها في نمو المحاصيل

.وأشجار الغابات وبعض خواص التربةا ، اسع ة اسخن ول ، خعة سمس جط ر، ة خمط خعة ص سا اسر يطا ، لا وخ ة اسوةيال

خول ير س ئ ور ا ، أوخة خوا رل ما

387

01 BIOLOGICAL EFFECTS OF HUMAN EXPOSURE TO

RADON-222 GAS IN BAGHDAD CITY NABEEL HASHIM

AMEEN AL-TAMEEMI

نبيل هاشم امين التميمي

397

00 TIGRIS RIVER WATER QUALITY ASSESSMENT BY USING

BENTHIC MACROINVERTEBRATES IN BAGHDAD CITY Neam N.Hashim , Fawzi Al-Zubaidi

404

02 INVESTIGATION OF LEAD AND CHROMIUM IN

PHYTOPLANKTON AND ZOOPLANKTON AT A SECTION

OF TIGRIS RIVER AT BAGHDAD CITY Hadeel R. Wahab, Fawzi S. Al-Zubaidi

412

الصفحة الحيوان علم–أسم البحث ت

03 في Zephyranthes candidaتأثير القلويدات المستخلصة من نبات زنابق المطر

للخاليا اللمفاوية وعلى النبيبات الدقيقة للخاليا الحيوانية الميتوزي االنقسام

H22 Hepatic cell line ابراهيم هادي محمد

423

الخلوية في مصل المرضى المصابين باألكياس المائية الكبدية تتقدير مستوى الحركيا 04 أول خعة اسصرر، ويةا رسية نا، أول ج ل ر هر معنف م ة اسخجية،

432

تأثير عصير الرمان على بعض الصفات التناسلية في ذكور الفئران 00أوخة م ل خعة ، معنف ة اسرض اس ر ، جةا سير ة ، ألي ص ا خصر ، أله ر روي ولي ،

.ص خجلال ةر

442

06 ROLE OF SILDENAFIL CITRATE(VIAGRA)® IN IN VITRO

SPERM ACTIVATION FOR Asthenozoospermic PATIENTS Usama I. M. Al-Zubaidi , Muhammad-Baqir M-R. Fakhrildin

449

07 ANTI LEISHMANIAL IGE ANTIBODY AS A MARKER FOR

DISEASE ACTIVITY IN CUTANEOUS LEISHMANIASIS

PATIENTS WITH SINGLE AND MULTIPLE SORES. Israa S. Musa, Ban N. AL- Qadhi, Nada M.AL-Bashir, Ali M. Aldein

461

08 CHRONIC LIVER DISEASES AND CIRRHOSIS: STUDY

AMONG RANDOM SAMPLES OF IRAQI INDIVIDUALS Amany M.Jasim

467

01 THE EFFECTS OF INSULIN LIKE GROWTH FACTOR -1

(IGF-1) ON THE PLASTICITY OF UMBILICAL CORD

BLOOD DERIVED MESENCHYMAL STEM CELLS

COLONIES TO IN VITRO DIFFERENTIATION Entedhar Kadhum Hussain, Intissar Numman Waheed

473


222

61 THE EFFECT OF EXTRACTED ALKALOIDS, PHENOLS,

AND TERPENOID OF ALBIZZIA LEBBECK (L.) BENTH. ON

THE BIOLOGICAL PERFORMANCE OF HOUSE FLY MUSCA

DOMESTICA L.(DIPTERA : MUSCIDAE) Fawzi S. Al-Zubaidi،Enas S. Al-Zubaidi

483

60 EFFECT OF THE NIGELLA SATIVA OIL ON REDUCTION

THE CONCENTRATION OF BLOOD GLUCOSE LEVEL IN

DIABETES MILLITUS PATIENT'S TYPE (1) AND (2) . Bushra Khalid Hassan, Enaam Aziz Jasim

492

تقدير كمية حامض السياليك في لعاب مرضى السرطان كمؤشر ورمي 62 لمةس ري لاير، م ل خوخة نا ال خرا ،س ض خول ة ،أيتخ ولتتي س

499

التأثيرات الناتجة في الكلية لوالدات جرذان األمهات المعاملة بخالت اليورانيل 63 ل لني اسريلا ،چولي ةا رية ، ص ا م صر اسطن

503

64 THE EFFECTS OF PIRACETAM ON SIMPLE REACTION

TIME IN NORMAL HEALTHY VOLUNTEERS Hayder M.Al-kuraishy , Ali I.Algareeb, Salah A. Al-windy

510

60 FALSE POSITIVE RESULTS IN SERODIAGNOSIS OF

Toxoplasma gondii IN PATIENTS WITH RHEUMATOID

ARTHRITIS. Khawla H. Zghair

517

في خفض تأثير L. Curcrcuma longaالكحولي لنبات الكركم ستخلصفعالية الم 66 االجهاد التاكسدي للفلوريد في ذكورالفئران البيض

هشام جميل ياسين ،ياسمين ابراهيم فرحان ،لبيب احمد الزبيدي

522

في التنبؤ بالتوزيع الجغرافي لذبابة التدويد ذات الرأس الكبير Climaxاستخدام نظام 67

Chrysomya megacephala ( Fab.) في محافظة بابل رياض علي عكيلي، عماد أحمد محمود ، باسم شهاب حمد ، أياد أحمد الطويل

530

68 HISTOLOGICAL CHANGES ON THE KIDNEY OF THE

OFFSPRING FROM MOTHERS TREATED WITH URANYL

ACETATE IN ALBINO RATS. Sabah N. Alwachi, Nusaibah Amer

542

61 HISTOPATHOLOGY OF THE KIDNEY TISSUE OF THE

FRESH WATER FISH, TILAPIA ZILLII EXPOSED TO

ALUMINUM Abdul-Hadi Abbas Hadi

550

71 THE EFFECTS OF THE EXTRACTED CRUDE TERPENOIDS

OF Melia azedarach L. ON SOME BIOLOGICAL ASPECTS OF

HOUSEFLY musca domestica L. (Diptera: Muscidae) Ali K. AL-Motery , Fawzi S. Al-Zubaidi

554

تأثير المستخلص الكحولي الخام لنبات القطب في أنزيمات كبد إناث االرانب المصابة بداء 70 السكري

ل را ل اسل ر ، ة اسخم ة اسخعةا سلاير

561

72 IgG –AVIDITY OF PRIMARY TOXOPLASMA INFECTION

FOR CONFIRMATORY TESTING OF PREMARITAL

FEMALES IN TWO REGIONS IN BAGHDAD PROVINCE (AL-

KARKH AND AL-RUSAFFA) Mahmood Abdul Razzaq Hassan AL-Shikhly , Ban Noori AL - Qadhi

573


226

73 ACTIVITY AND ISOENZYMES OF LACTATE

DEHYDROGENASE IN PATIENTS WITH URINARY

SCHISTOSOMIASIS IN BALAD ROUZ TOWN, DIYALA

PROVINCE N. Y. Al-Bayati, F. T. Mhaisen, N. M. Al-Bashir

582

من Bufo viridis (Laurenti, 1768)المجموعة الحيوانية المتطفلة على ضفادع 74 العراق قليم كوردستانٳ -مدينة اربيل

سخ خوخةاخي ةاهلل، هه ري الخ ي ةاسروخ ، جه ر ة سرية

587

70 المعوية في الخضراوات الطرية المجموعة من بعض اسواق مدينة دراسة مسحية للطفيليات

بغداد اسر ضا يوي د خ ، ل ةا ،

593

76

Polyctesis rhois والنوع .Polyctesis Marsتسجيل جديد للجنس Marseul, 1865 ضمن قبيلة Polyctesini (Buprestidae:

Polycestinae) في كوردستان العراق ولي س اسطنا ،خوخةص سا ةاسرل ، مة ل سص نا

602

الصفحة النبات علم –أسم البحث ت

كمعالجة أولية لبعض مياه ( ( Phragmites australisالقصباختبار كفاءة نبات 77 مجاري مدينة الموصل

لني أ راهي مةر اسمطيخا ،يوي ةاؤة هل اسخسعةاما ،أ راهي خر لطية اسوخةاما

610

والجبرلينت استجابة المجموع الجذري لشتالت االجاص للهيوم 78 اوخة ر سل ج ة

622

71 CONTAMINATION OF DRIED VINE FRUITS WITH

OCHRATOXIN A AND THEIR ASSOCIATED FUNGI Asia A.M. Saadullah , Samir K. Abdullah

628

81 EVALUATION OF Callistemon viminalis EXTRACTS AGAINST

ALGAE. Alaa, M. D. Al-Haidari; Abdul-latif M. Jawad , Neamat J. Al-Judy.

636

كفاءة الفطريات في خفض تراكيز االصباغ المطلقة من الصناعات النسيجية 80 ل سة س سا ول ، ولي نا ل دا ، امط م ر نا

643

المسلوق في فعالية االنقسام L. Brassica rapaتأثير مستخلص جذور نبات الشلغم 82 المايتوزي في الخاليا المرستيمية لجذور البصل

خري خر اوخة ،رس ري خوخة ،همة ولي ية ، يةاا خر اوخة

652

83 EFFECT OF OSMOTIC POTENTIAL OF ACTIVATOR

SOLUTION AND TEMPERATURE ON VIABILITY AND

VIGOUR OF WHEAT SEED. Jalal H. Hamza

, Michael P. Fuller

663

العليقة في بعض صفات الى (Eruca sativa)تأثير اضافة مسحوق بذور الجرجير 84 بالزما الدم إلناث أمهات دجاج البيض

ر ة و د رل ما، و ل ج ر اسةراجا

672


227

80 EXTRACTION OF PELLETIERINE FROM PUNICA

GRANATUM L. BY LIQUID MEMBRANE TECHNIQUE AND

MODELING Khalid M. Abed , Adel A. Al-Hemiri, Ayaad W. Al-Shahwany

684

النامية بريا في Nepeta L. (Labaitae)دراسة مورفولوجية لحبات طلع انواع الجنس 86 .العراق

لل ض اة اسج ر ، نا ولي يل اسخ ل

692

87 TAXONOMICAL STUDY OF Euphorbia hirta L.(Euphorbiaceae)

GROWN IN UNIVERSITY OF BAGHDAD CAMPUS-

JADIRIYAH Silva A. Zokian, Ali H. Al-Musawi , Abid Al-jasim M. AlJibouri

702

بيضاء 88 ال لذرة ا بيضاءاستجابة صنفين من ال لذرة ا SSoorrgghh]]استجابة صنفين من uumm bb ii cc oo lloorr ((LL.. ))

MMoo eenncchh لحقل[[ ا المائي تحت ظروف د لحقللإلجها ا المائي تحت ظروف د ..لإلجها

حجب الري خالل مراحل نمو المحصول وأثره في صفات نمو وحاصل الذرة البيضاء -3

ه س ر ة ر.، سلر ة اسول أوخة

710

والنسبة بينهما في مراحل تطور المداد إلى درنة للبطاطا GA3 ،ABAدراسة تراكيز الـ 81 .الزراعة المائية أنظمةصنف ريفيرا في

اوخة ا راهي اوخة ، لخير خوخة اوخة ،سلا ول يل ،ص ة م ل ص ة

721

مختلفة نباتية كثافات من الناتجة البيضاء الذرة بذور حيوية في الجبريليك حامض تأثير 11

جة ع س لضير، جي ة و ي صةا 729

دراسة التكوين النوعي للهائمات النباتية لنهر دجلة قبل دخوله مدينة بغداد وبعد خروجِه 10 العراق, منها

لهراا لهرا اسجم ا ، ة اسوخية خوخة ج اة اسط ية ، ة اسروخ ة اسج ر اس يلا

738

في Pomoideae(Rosaceae)حساب العدد الكروموسومي األحادي لمراتب العويئلة 12 مقاطعات كوردستان العراق

روباك توفيق عبد الرزاق ،عذية ناهي المشهداني

750

التابعة لمجموعة من االنواع البرية Porateدراسة مظهرية مقارنة لحبات الطلع الثقبية 13 جامعة بغداد /من ذوات الفلقتين النامية ضمن مجمع الجادرية

الراا ة اسرلا خجية ، نا ولي يل اسخ ل

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HISTOLOGICAL CHANGES ON THE KIDNEY OF THE OFFSPRING FROM MOTHERS TREATED WITH URANYL ACETATE IN...

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