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KEY WORDS

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1. INTRODUCTION

$8B(6D952C?E962D(2K(G6CBM35BIC(ME5BBD6D7(AIAA27T5I384(8IM(AI5UBC@4(6DE5BIMBC(98B(CB9BE962D(2K(C?E9I@(EI5E6D2AI(.%'/.&"(P#$%&Q(6D(*2598("AB56EIJ(K52A(ID(6DE6CBDEB(2K(=FVW(3B5(=<<J<<<(HB9GBBD(=XW>(IDC(=XWY(92(>;FY(3B5(=<<J<<<(6D(;<<Z=F(#?55BD9@4J(#$%&(5B35BTMBD9M(I3352L6AI9B@4(;<[(2K(DBG@4(ME5BBDTCB9BE9BC(H5BIM9( DB23@IMAM( 6D(*2598("AB56EI;J>F(16MBIMBT

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ABSTRACT

,-./012345

.?6CB@6DBM(5BE2AABDC(5IC6298B5I34(P!"Q(IK9B5(H5BIM9TE2DMB5N6D7(M?57B54(P'$&Q(K25(2396AI@(E2D952@(2K(C?E9I@(EI5E6D2AI(.%'/.&"(P#$%&QF($8B(I6A(2K(98B(35BMBD9(M9?C4(GIM(92(E8I5IE9B56^B(98B(5I9BM(2K(!"(E2DM6CB5I962D(IDC(

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678925:

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$%MQ(GB5B(BM96AI9BC(?M6D7(I(7BDB5I@6^BC(BM96AI96D7(BR?I962DM(5B75BMM62D(A2CB@F

"7:3;8:

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*24.;3:<24:

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2@CB5(G2ABD(G698(A2CB5I9B(25(MBNB5B(E2A25H6C6T==F(1BM369B( 98B(BM9IH@6M8BC(

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2. METHODS

=>?( @788<40(-45(A-8-(@231.7:

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=>=( A7:<04(-45(@835B(C2D3;-8<24

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ME@B52CB5AIW=<F< '4M9BA6E(@?3?M((

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G698(@2769(@6DU(IDC(BLE8ID7BIH@B(G25U6D7(E255B@I962D(M95?E9?5B(GIM(E2DM95?E9BC(92(IMMBMM(98B(IMM2E6I962D(HB9GBBD(35BC6E925(NI56IH@BM(IDC(ICA6D6M95I962D(2K(!"(IK9B5(9IU6D7(6D92(IEE2?D9(98B(E@?M9B56D7(2K(E8I5IE9B5T6M96EM(IA2D7(3I96BD9M(95BI9BC(H4(98B(MIAB(384M6E6ID(P98I9( 6MJ(384M6E6ID(GIM(5B3BI9BC(2NB5(3I96BD9MQF($8B(C6M956H?962D(GIM(IMM?ABC(92(HB(H6D2A6I@F(,D6NI56I9B(IDI@4M6M(IMMBMMBC(98B(?DICf?M9BC(IMM2E6I962DM(HB9GBBD(BIE8(35BC6E925( IDC( 98B(2?9E2ABF('?HMBR?BD9@4J( I@@(35BC6E925M(GB5B(6DE@?CBC(6D(98B(7BDB5I@6^BC(BM96AI9T6D7(BR?I962D(A2CB@F(#2@@6DBI5694(HB9GBBD(NI56IH@BM(GIM(IMMBMMBC(?M6D7(I(OBI5M2D(E255B@I962D(AI956LJ(IDC(IM( I( 5BM?@9J( 5BM6CBDEB(GIM(2A699BC( K52A( 98B(A2CB@(HBEI?MB(2K(69M(E255B@I962D(G698(C6M9IDEB(92(98B(82M369I@(

T56I@(1B356NI962D()DCBL(IDC(C6M9IDEBJ(#8I5@M2D(ME25B(IDC(C6M9IDEBJ(#8I5@M2D(ME25B(IDC(BAB57BDE4(522A(N6M69MJ(#8I5@M2D(ME25B(IDC(I7BJ(M?57B2DaM(BL3B56BDEB(IDC(3I96BD9(I7BJ(M?57B2DaM(BL3B56BDEB(IDC(3I96BD9aM(#8I5@M2D(ME25BQ(GB5B(6D952C?EBC(6D92(98B(A2CB@(2DB(

T6D7(BR?I962D(A2CB@(GIM(<F<;VF("@@(P(NI@?BM(I5B(K25(

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3. RESULTS

E>?( C-8<748J(@310724J(-45(@788<40(*9-1-.871<:8<.:

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O52EBC?5BM(5B@I9BC(92(98B(EI5B(2K(35B7DID9(G2ABD

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3I96BD9(IDC(5IC6I962D(98B5I36M9

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<VYY>J(<VY_ZJ(<VY=V

O52EBC?5BM(E255BM32DC6D7(92(98B(352N6M62D(2K(

5IC6298B5I34(95BI9ABD9M

%&'()*+2 N&.*%'E-'#$,.*%1

!"#$%&'()*!+,-*#)*.($/-(0"*".-0-*$(%!(1#)'

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GB5B( 82M369I@6^BC( K25( 5BIM2DM( ?D5B@I9BC( 92( H5BIM9(EIDEB5(6D(98B(4BI5(HBK25B(98B65(C6I7D2M6MJ(IDC(;>[(8IC(N6M69BC(98B(BAB57BDE4(522AF

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E>=( K:7(2G(")(<4(L37M7.

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$8B(352N6M62D(2K(!"(E2DM?@9I962DM(GIM(8678BM9(K25(98B(Y<]_X(I7B(752?3(PVZFV[Q(IDC(@2GBM9(K25(98B(V<(25(2@CB5(I7B(752?3(PYYFZ[QF($8B(2NB5I@@(!"(E2DM?@9I962D(

")'1,0%%%( iIMB@6DB(CBA275I386E(IDC(E@6D6EI@(E8I5IE9B56M96EM(2K(98B(3I96BD9M

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4. DISCUSSION

)D( 98B( 35BMBD9( M9?C4J(GB( E8I5IE9B56^BC( 98B( 5I9B( 2K(7?6CB@6DBT5BE2AABDCBC( !"( E2DM6CB5I962D( H4( IMTMBMM6D7(E2DM?@9I962D(IK9B5('$&(K25(3I96BD9M(G698(#$%&(

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jB(UD2G(98I9J(6D(98B(,D69BC('9I9BMJ(98B(5I9B(2K(!"(

5B762DF("D(IDI@4M6M(2K(0BC6EI6CT6DM?5BC(3I96BD9M(6D(*2598(#I52@6DI(M82GBC(98I9(V=[(5BEB6NBC(7?6CB@6DBT5BE2AABDCBC( !"( C?56D7( 98B( 4BI5M( ;<<>];<<W>=F($8B(5I9B(2K(!"(?MB(6D(`?BHBE(GIM(M6A6@I5(25(M@6789@4(8678B5F()9(C6C(D29(NI54(G6CB@4(K25(8BIN6@4(?5HID6^BC(I5BIMJ(H?9(69(GIM(@2GB5(K25(98B(A25B(5?5I@(5B762DM(2K(98B(352N6DEBJ(BLEB39(*25CTC?T`?BHBEF($8B(8678B5(2HTMB5NBC(5I9B(2K(!"(?MB(6D(98I9(5B762D(E2?@C(HB(I(5BM?@9(2K(5IDC2A(B5525(M9BAA6D7(K52A(98B(NB54(MAI@@(D?AHB5(2K(EIMBM(P%(n(WQ(INI6@IH@B(K25(98I9(5B762D(25(K52A(98B(KIE9(98I9(I@@(EIMBM(K52A(98I9(5B762D(I5B(8IDC@BC(H4(I(

3I96BD9(95IEU6D7(IDC(BLBE?962D(2K(52?96DB(35IE96EBMF(

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5. CONCLUSIONS

jB(K2?DC(98I9(V>F<[(2K(G2ABD(G698(#$%&(G82(?DTCB5GBD9(I('$&( 6D(`?BHBE(K52A(=XXV( 92(;<<Y(GB5B(E2DM6CB5BC( K25( 7?6CB@6DBT5BE2AABDCBC(!"F(,MB(2K(!"4BI5M(2K(I7B(IDC(2@CB5(IDC(982MB(G82(@6NBC(KI598B5(98ID(=<<(UA(K52A(I(CBM67DI9BC(EBD95B(K25(H5BIM9(EI5B(

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6. ACKNOWLEDGMENTS

$8B(#IDIC6ID(#IDEB5('2E6B94(&BMBI5E8()DM969?9BJ(98B(#IDIC6ID()DM969?9BM(2K(/BI@98(&BMBI5E8J(IDC(98B(#BTCI5M(#IDEB5()DM969?9B(352N6CBC(K?DC6D7(K25(986M(M9?C4F

7. CONFLICT OF INTEREST DISCLOSURES

92(CBE@I5BF

8. REFERENCES

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( >F( %@6N2992( )"J(iIDEBf(#J(.2B@(bJ($&' 5+1(jI696D7( 96ABM( K52A(IHD25AI@(H5BIM9(ME5BBD(92(C6I7D2M6M(6D(W(#IDIC6ID(352N6DEBMF(!?;]';<<=\=_YS;WW]V>F

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