AnnuAl RepoRt - Queensland Parliament

AnnuAl RepoRt

2010–2011

Copies of this Annual Report are available on QIMR’s website at www.qimr.edu.au/annualreport and at no cost by contacting QIMR on (07) 3362 0222, freecall 1800 993 000 or by emailing [email protected].

Queensland Institute of Medical Research300 Herston Road, Herston, Queensland Australia 4006T: +61 7 3362 0222F: +61 7 3362 0102W: www.qimr.edu.au

QIMR is committed to providing accessible services to people from culturally and linguistically diverse backgrounds. If you have difficulty in understanding the annual report, you can contact us on (07) 3362 0222 and we will arrange an interpreter to communicate the report to you.

ISSN 1839 – 1877

© 2011 Queensland Institute of Medical Research

AnnuAl RepoRt

2010–2011

Letter of compliance 2

Research highlights 3

Awards and achievements 6

QIMR at a glance 8

Message from our Patron 10

Chairman’s report 11

Director’s report 12

Our organisation 14

Our people 19

Our governance 22

Our management 27

Our performance 32

Our research 48

Supporting our research 70

Financial statements 72

Awards 111

Invited lectures 112

Graduated students 124

Student awards 125

Patents 127

Grants and funding 129

QIMR Fellows 131

Overseas travel 132

Scientific publications 133

Compliance checklist 154

Acronyms 156

Contents

124Graduated students

Our organisation

Our people

Page 1

Letter of compLiance

300 Herston Road, Herston Q 4006 Australia | QIMR Locked Bag 2000, Royal Brisbane Hospital Q 4029

T (617) 3362 0222 F (617) 3362 0111 W www.qimr.edu.au

31 August 2011

The Hon Geoff Wilson MP Minister for Health Parliament House BRISBANE QLD 4000

Dear Minister

I am pleased to present the Annual Report 2010–2011 for the Council of the Queensland Institute of Medical Research.

I certify that this Annual Report complies with:

• the prescribed requirements of the Financial Accountability Act 2009 and the Financial and Performance Management Standard 2009; and

• the detailed requirements set out in the Annual Report Requirements for Queensland Government Agencies.

A checklist outlining annual reporting requirements can be found on the final pages of this Annual Report or accessed at our website:

http://www.qimr.edu.au/annualreport

Yours sincerely

PROFESSOR JOHN HAY AC Chair QIMR Council

Page 2 QIMR Annual Report 2010–2011

ReSeARCH HIGHlIGHtS2010-11 CANCER

Identified small changes in a section of DNA associated with an increased breast cancer risk in women who carry the mutated BRCA1 gene.

Discovered that 75% of oesophageal cancers in Australia can be attributed to obesity, acid reflux and smoking.

Identified several new genes that increase the risks of melanoma, cancers of the breast, ovary, prostate and endometrium.

Identified a potential new cancer treatment that reduces the size of cancerous tumours by blocking the function of microRNA.

Discovered that although Indigenous Queenslanders are 21% less likely to be diagnosed with cancer than the total Queensland population, they are 36% more likely to die from cancer.

Found that using sunscreen every day can halve the risk of developing melanoma.

Found that for ovarian cancer patients, decreasing the time between symptom onset and diagnosis will not improve survival rates.

Began Phase I clinical trials using a monoclonal antibody as a potential cancer treatment for acute leukaemias, melanomas, brain tumours and lung cancers.

Influenced a major change in clinical practice with the acceptance nationally and internationally that it is important to remove proximal serrated polyps from the colon.

Image source: National Cancer Institute , Dr Cecil FoxImage source: National Cancer Institute , Dr Cecil Fox

Page 3

ReSeARCH HIGHlIGHtS

2010-11 INFECTIOUS DISEASES

Developed a computer system for tracking mosquito-borne disease such as Ross River fever and Barmah Forest virus disease.

Discovered new regions of the Epstein-Barr virus that are targeted by the immune response.

Established a system to test antimalarial drugs in human volunteers infected with malaria parasites.

Undertook a pilot study, releasing Wolbachia infected mosquitoes in Cairns to test the effectiveness against the spread of dengue fever.

Found that applying clove oil is as effective at killing scabies mites as other existing treatments.

Demonstrated the efficacy of novel proteins for the treatment of schistosomiasis.

Identified new antimalarial compounds from plants and fungi.

Completed preclinical testing of a vaccine for cytomegalovirus, which aims to prevent clinical complications in transplant patients and newborn babies.

Obtained data to support a causal link between scabies and streptococcal infections.


ReSeARCH HIGHlIGHtS

2010-11 MENTAL HEALTH /COMPLEX DISORDERS

Published the world’s largest genome-wide association study for major depression which showed the disease is underpinned by many small genetic variants, and implicated a protein called galanin.

Developed a new diagnostic and monitoring test for major depression based on a combination of video and imaging technology.

Developed a brain stress test for dementia using brain imaging and showed that it could predict the functioning of patients for up to two years.

Discovered that eating or drinking full-fat dairy may reduce the risk of cardiovascular-related death.

Found 59 new DNA regions that influence levels of LDL and HDL cholesterol and triglycerides in the blood – key indicators of heart disease risk.

Discovered new genes for myopia (long or short sightedness), optic nerve hypoplasia (one of the leading causes of blindness in children) and glaucoma risk.

Discovered 30 new genes that control the age of sexual maturation in women and identified several genetic links between early puberty and body fat.

Located new genetic regions that increase endometriosis risk and demonstrated a stronger genetic contribution to more severe cases of the disease.

Demonstrated that liver fibrosis identified via liver biopsy, predicts the future development of clinically significant liver disease (portal hypertension) in children with cystic fibrosis (CF) and should be adopted clinically.

Page 5

AWARDS ANDACHIevementS

QIMR was inducted into the Queensland Business Leaders Hall of Fame.

Professor Geoff Hill (Immunology Department Coordinator and Head of the Bone Marrow Transplantation Laboratory) was awarded a prestigious National Health and Medical Research Council (NHMRC) Australia Fellowship. He also received a Senior Clinical Research Fellowship from the Queensland Government.

Professor Emma Whitelaw (Cell and Molecular Biology Department Coordinator and Head of the Epigenetics Laboratory) was elected as an Australian Academy of Science Fellow, and received both the Australia and New Zealand Society for Cell and Developmental Biology President’s Medal and the International Union of Biochemistry and Molecular Biology Jubilee Medal.

Professors Kum Kum Khanna (Head of the Signal Transduction Laboratory) and Georgia Chenevix-Trench (Cancer Program Coordinator and Head of the Cancer Genetics Laboratory) were awarded a medical research program grant from the NHMRC. The grant worth $5.6 million over five years will be used to support research into the susceptibility and progression of breast cancer.

Professor James McCarthy (Infectious Diseases Program Coordinator and Head of the Clinical Tropical Medicine Laboratory ) and Professor Michael Breakspear (Mental Health/Complex Disorders Program Coordinator and Head of the Systems Neuroscience Group) were awarded Health Research Fellowships from the Queensland Government for their work in malaria and mental health respectively.

Professor Don McManus (Head of the Molecular Parasitology Laboratory) received an honorary membership of the American Society of Tropical Medicine and Hygiene, in recognition of outstanding accomplishment by an individual not an American citizen who has made eminent contributions to some phase of tropical medicine and hygiene.

Dr Patricia Valery (Indigenous Health Program) was awarded a NHMRC Excellence Award, the highest ranking Career Development Award in the category of population health.

Dr Sarah Medland (Genetic Epidemiology Laboratory) was awarded a 2010 Queensland Young Tall Poppy Science Award.

Professor Michael Breakspear and Dr Susan Woods (Oncogenomics Laboratory) won 2011 Australian Society for Medical Research (ASMR) Queensland Awards.


research agreements patent portfolio

Business development agreements

Research service agreements

Clinical trial agreements

Commercialisation agreements

Intellectual property agreements

License agreements

Others






License agreements

Others

Patent portfolio 2010-2011

Vaccine Patents

New Treatment Patents

Drug Target Patents

Diagnostic Patents

Delivery Platform Patents


Vaccine Patents


Drug Target Patents

Diagnostic Patents


QImR At A GlAnCe

nHmrc grants awarded ($ millions)

0

5

10

15

20

20112010200920082007

FellowshipsGrants


fundraising revenue ($ millions)

Fundraising

0

2

4

6

8

10

2010/112009/102008/092007-082006-07

Event RevenueDonations & Gifts

Bequests / Gifts in KindSponsorships

Staff numbers

Scientific publications

0

100

200

300

400

500

600

20112010200920082007

High Impacts (publications in journals with impact factors of 10 or more)Articles

0

100

200

300

400

500

600

20112010200920082007

StudentsStaff

undraising revenue ($ millions)undraising revenue ($ millions)fundraising revenue ($ millions)

10

fundraising revenue ($ millions)

10

undraising revenue ($ millions)

Students

2007

Staff

Page 9

meSSage from our patron

QIMR Annual Report 2010-11Patron’s Message

2010-11 was a challenging year for QIMR, in some ways, but one which nevertheless delivered many gains and advances, for the Institute itself and for the individual researchers and research teams working across its diverse research program, consolidating its reputation as one of Australia’s most highly regarded and most successful medical research institutes.

The decision by Professor Michael Good AO to relinquish his position as Director and CEO, after ten years of committed and energetic leadership, to concentrate on his own research, posed a significant challenge for the Council, needing to find a worthy successor and assure a smooth transition during a period of significant expansion and ongoing growth.

The appointment of distinguished molecular biologist, Professor Frank Gannon of Ireland - after an extensive national and international search - however, met this challenge admirably, assisted by the contribution of Professor Adèle Green, who stepped into the Director role for several months. I congratulate Professor Gannon on his appointment and welcome him most warmly to Queensland, as I thank Professor Green, equally warmly, for her steady leadership at a demanding time for the Institute and its 600 scientists, staff and students.

Many of those demands, of course, related to the major expansion of QIMR’s research facilities ongoing through the year and now approaching completion. Professor Gannon has joined the Institute at a significant point in its development. Following a decade of impressive achievements under Professor Good, QIMR is now approaching what is arguably the most exciting period in its history, with the imminent completion of the state-of-the-art Smart State Medical Research Centre at Herston in 2012.

The capacity and capability that this Centre will add is immense, creating new opportunities for many more hundreds of scientists to pursue the Institute’s mission of preventing and curing disease through research, and it is they who will further cement the reputation of QIMR – and of Queensland – as a centre of excellence in this field. It is no exaggeration to say that their explorations could affect the health and hopes of millions, as they work to unravel the secrets of the diseases and conditions that confront contemporary society, to find answers to those still unsolved medical riddles and puzzles and to realise the scientific break-throughs we all want to see in our lifetime.

I congratulate and thank the Council, staff and supporters of the Institute for all they have done throughout the year to build and strengthen QIMR. I was particularly delighted to see the Institute inducted into the Queensland Business Leaders Hall of Fame in September, 2010 and to have the honour, as Governor, of presenting this highly prestigious award to Council Chairman, Professor John Hay AC, accepting it on behalf of all QIMR scientists and staff. It was just recognition of QIMR’s significant contribution to Queensland - a contribution I have every confidence will be sustained and enhanced during the year ahead.

Penelope Wensley AC Governor of Queensland


cHairman’S reportIn January 2011, we welcomed Professor Frank Gannon as QIMR’s seventh Director and CEO. Professor Gannon, an internationally renowned expert in the field of molecular biology has significant experience in managing science, widespread ties with the international scientific community and a passion for scientific excellence.

I would like to pay tribute to Professor Adèle Green, who stepped into the Director role until Professor Gannon commenced.

Professor Gannon’s appointment comes at a particularly important juncture in QIMR’s history. The Institute is poised for a period of exponential growth and research achievements when our new 15 floor research facility is completed in early 2012. The capital expansion was made possible by a most generous gift from The Atlantic Philanthropies, and funding from the State and Federal Governments.

A highlight of the new building will be a piece of art commissioned by acclaimed Indigenous artist Ms Judy Watson. This three-storey piece will be featured in the foyer of the new facility, greeting visitors and encapsulating the history of both QIMR and the local Herston area.

QIMR continues to be recognised as one of Australia’s largest and most successful medical research institutes. This year I had the honour of representing QIMR when we were inducted into the Queensland Business Leaders Hall of Fame.

We have also embarked on our largest signature fundraising event – the Rio Tinto Ride to Conquer Cancer. The event promises to both raise the profile of QIMR as well as raise much needed funds for our Cancer Program. Thank you to Rio Tinto and Sunsuper for sponsoring this event. I would also like to acknowledge the ongoing support of Suncorp, who continue to support our skin cancer research.

A change to the Queensland Institute of Medical Research Act 1945 saw the abolition of the QIMR Trust. The role of Trust has been absorbed by the QIMR Council and I would like to take the opportunity of thanking the members of Trust for their commitment and guidance over the past 31 years.

I would like to acknowledge the significant contribution of Mr Clive Berghofer, who has been a major supporter of QIMR for the past 10 years, Mr Chuck Feeney whose vision and support was instrumental for the construction of our new facility and former Director, Professor Michael Good, whose leadership enabled QIMR to achieve its vision of better health through medical research.

QIMR Council Chairman Professor John Hay AC

Her Excellency, the Governor of Queensland Ms Penelope Wensley AC presents the Queensland Business Leaders Hall of Fame award to Professor John Hay AC, Chairman of QIMR Council.

“QIMR continues to “QIMR continues to be recognised as be recognised as one of Australia’s one of Australia’s largest and most largest and most successful medical successful medical research institutes.”research institutes.”

Chairman of QIMR Council.

Page 11

Director’S reportIt is with great pleasure that I write my first annual report as Director and CEO of the Queensland Institute of Medical Research. Taking over from Michael Good is both a challenge, because of what has been achieved in the past ten years, and a benefit because much of what is needed for QIMR is already in place.

Since its inception in 1945, QIMR has become a world recognised centre of excellence for medical research. Our research continues to make an enormous impact on the health of society and it has been another productive year for the Institute.

In response to a review of the current strengths of QIMR and the opportunities and future needs, I have prepared a roadmap. This will allow us to concentrate our research effort on areas that are of high importance to Queensland including regionally relevant diseases and those that are major causes of mortality and morbidity to the community. Our research will focus on cancer; infectious diseases; and mental health/ complex disorders. These scientific activities will be supported by cross program departments in Immunology, Genetics, Population Health, Computational Biology, Biology, Cell and Molecular Biology to increase collaboration across the Institute.

I am excited about the new direction for the Institute as we move into a period of growth. We will be recruiting to further strengthen QIMR in priority areas such as computational biology, imaging, mental and infectious diseases, as well as increasing the number of students supported at the Institute. We will also be working to further support our current researchers by providing world-class facilities, the best equipment and training, as well as providing clear career paths and financial security.

In order to make a real benefit to society, I believe our research has to go beyond the laboratory and be effectively translated into the clinical setting. This has been achieved in many disease areas (highlighted elsewhere) including the development of an online based system to help track mosquito-borne diseases such as Ross River fever; clinical trials that have began for a new antibody that has been effective as a treatment against acute leukaemia; and we have embarked on the largest ever purpose built study of skin cancer in order to develop an effective predictive tool for general practitioners.

QIMR continues to employ and support excellent researchers. Special congratulations must go to Professor Geoff Hill who was awarded a NHMRC Australia Fellowship, which will be used to continue to improve the outcome for bone marrow transplant patients; Professor Emma Whitelaw who has been recognised as one of the world’s leading epigeneticists having been elected as an Australian Academy of Science Fellow and receiving the International Union of Biochemistry and Molecular Biology Jubilee Medal; and Dr Susan Woods

who not only won ASMR’s Senior Researcher Award but was also awarded a joint Cancer Australian and Cure Cancer Foundation Research Grant for her work on the regulation of melanoma growth.

QIMR continues to provide excellent research facilities for over 400 researchers. On 29 March 2011, we celebrated the topping out of our new 15 floor research facility made possible by generous support from the Commonwealth and Queensland Governments and The Atlantic Philanthropies. The building, due for completion in early 2012, will include 20 purpose built laboratories and increase QIMR’s current research capacity in areas such as tropical diseases, vaccine development, cancer and genetics. It will allow the expansion of our mental health research, as well as QIMR’s highly successful Education Program.

Located in the heart of the Herston medical campus, QIMR is well placed to bridge the gap between scientists and clinicians. As it expands, QIMR will place a particular emphasis on increasing the frequency of these interactions and incorporating researchers with a clinical background into our laboratories. To achieve this we will expand our bioseurity capability, and maintain our good manufacturing practice (GMP) facilities.

In addition to the Herston based activities, we will work to strengthen current collaborations and continue to build our relationships with universities and other medical research institutes.

I want to thank our team of dedicated researchers for their hard work and determination. Thanks also to all the corporate staff for providing the services and support needed to make our Institute what it is today. I look forward to working with Council and staff to continue to build on our world-class reputation and take QIMR into the future.

Professor Frank Gannon Director and CEO

“i am excited about the new direction for the institute as we move into a period of growth.”


QIMR Annual Report 2010–2011

ouR oRGAnISAtIon

Page 15

our vision

to be a world renowned medical research institution

our mission

Better health through medical research

our philosophy

Qimr supports scientists who perform world-class medical research aimed at improving the health and well-being of all people

our organiSation

role and main function QIMR was established under the Queensland Institute of Medical Research Act 1945 for the purpose of research into any branch or branches of medical science.

QIMR is a world leading medical research institute. Our research focuses on three areas: cancer; infectious diseases; and mental health and a range of complex disorders.

Working in close collaboration with clinicians and other research institutes, our aim is to improve health by developing prevention strategies, new diagnostics and better treatments.


government objectives for the communityQIMR conducts medical research that supports the Queensland Government’s Smart State Strategy 2005–2015 and Towards Q2: Tomorrow’s Queensland ambitions of Healthy – Making Queenslanders Australia’s healthiest people and Strong – Creating a diverse economy powered by bright ideas. This is evidenced by research undertaken by QIMR across the three research programs that focuses on areas of high importance to Queensland including those that are major causes of ill health and death.

In particular, QIMR supports the Queensland Government’s commitment to making Queenslanders Australia’s healthiest people and, through the Toward Q2 strategy, targets to reduce tobacco smoking, overweight and obesity, risky alcohol consumption, and unsafe sun exposure by one-third by 2020.

In 2010, QIMR embarked on the largest skin cancer research study every conducted in Australia. More than 200,000 men and women will be invited to participate in the QSkin study, which aims to help us better understand the factors that underlie skin cancer risk. QIMR researchers found that using sunscreen every day can halve the risk of melanoma and discovered that 75% of oesophageal cancers in Australia can be attributed to obesity, acid reflux and smoking.

machinery of government changesThe Queensland Institute of Medical Research Act 1945 was amended by legislation, entitled the Water and Other Legislation Amendment Act 2010. This was enacted and assented to by the Queensland Parliament on 25 November 2010. As per section 137 of the Amendment Act, the Trust was abolished on 1 February 2011. Responsibilities of the Trust have been transferred to the QIMR Council.

The QIMR Final Trust Annual Report can be found at www.qimr.edu.au/trustreport or a copy can be obtained by calling (07) 3362 0222 or freecall 1800 993 000.

operating environment

rapid growthQIMR is preparing for a period of accelerated growth with the construction of a 15 floor research facility scheduled for completion in early 2012. QIMR will be actively recruiting researchers in specific areas in order to increase its capacity by 50% to approximately 1,000 staff and students.

competition for fundingQIMR operates in a competitive environment with much of its research funded by competitive grants obtained by our researchers. For the 2010–2011 year, QIMR researchers secured more than $21 million in funding from NHMRC.

Funds were provided from 1 January 2011 for a total of 17 new research projects ranging from the genetics of brain structure and function, to understanding the causes and risks of breast and ovarian cancers, to improving the health of Indigenous populations.

economic climateThe global financial crisis has impacted philanthropic giving for both individuals and the corporate sector. In this environment, with a large number of charities competing for the fundraising dollar and especially after the devastating Queensland floods, securing funding to support our operating costs has been even more challenging. However, QIMR continues to secure ongoing funding support from the community and valued donors.

Decline of students completing science degreesOver the next few years, QIMR will recruit up to an additional 500 scientists. Regrettably, the number of students completing science degrees is declining, with less than 10% of undergraduates enrolling in science related degrees. As a society that relies on medical research to improve our health, we must ensure a continual supply of researchers into the future. QIMR is committed to inspiring the scientists of tomorrow through its Education Program which saw over 1,000 senior school students tour QIMR and hear first-hand from researchers about medical research and potential career options.

Page 17

objectivesQIMR is committed to better health through medical research by achieving the following objectives:

1. To transfer outstanding fundamental knowledge and understanding from the laboratory to the clinic in the form of improved diagnostics, prevention and treatment strategies;

2. To perform excellent world class research;

3. To seek and utliise commercial opportunities and to diversify income sources;

4. To perform research with consequence and have a positive impact on society; and

5. To continue to build QIMR’s world leading reputation.

Our performance against the outputs translation, scientific quality, commercial consequence, societal impact and international reputation is detailed in our performance section on page 32.

future outlookExcellence in research and researchers will continue to characterise QIMR under the leadership of Professor Frank Gannon and the QIMR Council. The future goals for the Institute are to:

1. Become a world leader in medically relevant research and the transfer of this knowledge and understanding to the clinic;

2. Focus on areas that are of high importance to Queensland including regionally relevant diseases and those that are major causes of mortality and morbidity to the community; and

3. Undertake outstanding fundamental research of direct relevance to the research that is closer to translation.

Our vision to be a world renowned medical research institution will be achieved by focusing QIMR’s research on cancer, infectious diseases and mental health/complex disorders. Research activities, particularly in systems biology and computational biology, will be strengthened to further support excellent translational research.

QIMR will build on existing inter-institutional collaborations and continue to strengthen collaborations on the Herston campus, including the RBWH, in order to increase the health outcomes of our research. Opportunities to diversify sources of income for QIMR will be sought with a particular emphasis on identifying and leveraging commercial opportunities that arise naturally from excellent research.

QIMR will support and develop staff and provide funding stability for outstanding early stage and senior research scientists.

progress Changes have already been implemented in line with the new direction for QIMR. QIMR’s activities are now organised into three programs with disease related themes: Cancer, Infectious Diseases and Mental Health/Complex Disorders. These will be underpinned by the following departments: Immunology, Genetics, Population Health, Computational Biology, Biology and Cell and Molecular Biology. Each research group will align itself with at least one program and one department.

The individual laboratories remain the core entities of QIMR and the programs and departments are established to provide functioning support for the laboratories. Coordinators of each program and department will collectively provide a strong input from all scientists into the decision making processes of QIMR through the Management Advisory Group (MAG). This has replaced the previous Interim Management Executive Committee (IMEC).


our peopLeQIMR has 567 employees. Due to the reliance on short-term grant funding, 83.72% of employees are employed on fixed-term contracts. In 2010–2011, 91.52% of permanent FTE staff who were employed with QIMR as at 1 July 2010 were retained (i.e. still employed as at 30 June 2011) by the organisation.

Taking into account the number of permanent FTE employees as at 1 July 2010, a slight increase in recruitment for new permanent positions over the reporting period, and the number of employees who voluntarily ceased (e.g. resigned) from the organisation, QIMR experienced a separation rate (or turnover) of 13.26% over the reporting period. These figures continue to reflect a stable and permanent workforce consistent with previous years.

63.81% of QIMR’s workforce and 60.58% of the current student population are women. Women hold 33% of QIMR’s scientific leadership positions. This compares to 15% in 2003.

Workforce planning, attraction and retentionWorkforce planning initiatives at QIMR include an Education and Higher Degrees program to attract students to medical research and a career at QIMR, the ongoing support for a culture of work and life balance to attract and retain employees, and maximising salary benefits for employees. Resource planning is limited by short term funding cycles for research employees; however within the Corporate Division QIMR has planned resourcing requirements to ensure growth is supported when the new building is completed in 2012.

The strategic plan for QIMR has identified priority recruitment in the areas of bioinformatics, systems biology, basic immunology, and imaging in cell biology and scientific recruitment will be focussed on these areas over the next 12 months. Initial attraction efforts have focused on increasing exposure, and strengthening QIMR’s reputation both nationally and internationally.

A key attraction strategy at QIMR is the promotion of work/life balance. Initiatives include access to variable working hours, flexible working arrangements, flexible leave options (including taking leave at half pay), and the implementation of a child care policy to support parents returning to work after the birth of a child.

QIMR is covered by the QIMR Enterprise Agreement 2010, which expires on 31 August 2011 and is to be replaced by a new agreement. QIMR has in place a range of workforce policies that support the operation of the agreement and the achievement of strategic objectives, addressing workplace conduct and performance, professional and career development, leave provisions and remuneration.

ethics and code of conductQIMR has in place a Code of Conduct which sets out the expected standards of the official conduct, relationships and behaviour for staff.

carers act 2008QIMR’s Human Resource policies were reviewed to ensure that they comply with obligations set out for public authorities under the Carers Act 2008. QIMR provides access to flexible working arrangements, flexible leave options, a child care assistance policy, and definitions of a carer compliant with the Act. Employees have access to information regarding benefits and policy on the QIMR intranet.

development, leave provisions and remuneration.

Page 19

Director

QIMR Council

Administrative Support

Deputy Director

Management Advisory Group

Cancer Genetics

Radiation Biology & Oncology

Oncogenomics

Molecular Cancer Epidemiology

Skin Cancer Carcinogenesis

CCQ Transgenics

Familial Cancer

Systems Neuroscience

Malaria Biology

Protein Discovery CentreHIV Molecular Virology

Parasite Cell Biology

Scabies

Clinical Tropical Medicine Mosquito Control

Bioinformatics

Cellular Immunology Molecular Vaccinology

Immunology & InfectionClinical Immunohaematology

Bone Marrow Transplantation

Tumour ImmunologyDendritic Cells & Cancer

Cancer Control Group

Immunovirology

Leukaemia Foundation of Queensland

Cancer Immunotherapy

Signal Transduction

RBWH Foundation Conjoint Gastroenterology

Drug Discovery Group

Membrane Transport

Indigenous Health

Cancer & Population Studies Neurogenetics

Gynaecological Cancer Group

Epigenetics

EBV Biology

Immunity & Vaccinology

Tropical Parisitology

Antigen Presentation & Immunoregulation

Bacterial Pathogenesis

Cancer Program Infectious Diseases Program

Corporate Division

Finance

Grants

Safety

Regulatory Affairs

Procurement

Human Resources

Information Services

External Relations

Scientific Services


Building Services

Business Development

Mental Health/Complex Disorders Program

Malaria Drug Resistance& Chemotherapy

Inflammatory Bowel Disease

Molecular Parasitology

Iron Metabolism

Hepatic Fibrosis

Genetic Epidemiology

Molecular Epidemiology

Qld Statistical Genetics

Psychiatric Genetics

Indigenous Health

Tumour Immunology

Cancer Genetics

CCQ Transgenics


Membrane Transport

Epigenetics

Key

Laboratory is also represented in another program

organiSationaL Structure


Director

QIMR Council


Deputy Director

Management Advisory Group

Cancer Genetics


Oncogenomics

Molecular Cancer Epidemiology

Skin Cancer Carcinogenesis

CCQ Transgenics

Familial Cancer

Systems Neuroscience

Malaria Biology

Protein Discovery CentreHIV Molecular Virology

Parasite Cell Biology

Scabies

Clinical Tropical Medicine Mosquito Control

Bioinformatics

Cellular Immunology Molecular Vaccinology

Immunology & InfectionClinical Immunohaematology

Bone Marrow Transplantation

Tumour ImmunologyDendritic Cells & Cancer

Cancer Control Group

Immunovirology

Leukaemia Foundation of Queensland

Cancer Immunotherapy

Signal Transduction

RBWH Foundation Conjoint Gastroenterology

Drug Discovery Group

Membrane Transport

Indigenous Health

Cancer & Population Studies Neurogenetics

Gynaecological Cancer Group

Epigenetics

EBV Biology

Immunity & Vaccinology

Tropical Parisitology

Antigen Presentation & Immunoregulation

Bacterial Pathogenesis

Cancer Program Infectious Diseases Program

Corporate Division

Finance

Grants

Safety

Regulatory Affairs

Procurement

Human Resources

Information Services

External Relations

Scientific Services


Building Services

Business Development


Malaria Drug Resistance& Chemotherapy

Inflammatory Bowel Disease

Molecular Parasitology

Iron Metabolism

Hepatic Fibrosis

Genetic Epidemiology

Molecular Epidemiology

Qld Statistical Genetics

Psychiatric Genetics

Indigenous Health

Tumour Immunology

Cancer Genetics

CCQ Transgenics


Membrane Transport

Epigenetics

Key

Laboratory is also represented in another program

Page 21

our goVernance

council purpose and membershipIn accordance with Part 2, Section 4A of the Queensland Institute of Medical Research Act 1945, QIMR is controlled and governed by The Council of the Queensland Institute of Medical Research (“The Council”). Under the Statutory Bodies Financial Arrangements Act 1982, the QIMR Council is a statutory body.

functions of the councilThe functions of the QIMR Council are to:

(a) control and manage the Institute;

(b) raise and accept moneys for the purposes of the Institute;

(c) invest moneys raised or accepted by the Council for the purposes of the Institute; and

(d) invest moneys derived from any property or other invested moneys of the Council for the purposes of the Institute.

number of meetingsAttendance by Members of Council who held office during the 2010–2011 financial year are as follows:

Appointed Members Meetings Attended

John Hay 7

Bryan Campbell 7

Judith Clements 5

Chris Coyne 4

Paul Fennelly 2

Lyn Griffiths 4

Paula Marlton 5

Jeannette Young 7

Secretary: Donna Hancock 6

remuneration of councilThe aggregate remuneration for the QIMR Council for the 2010–2011 financial year was $51,837.

membership of the councilThe Council consists of the following members appointed by the Governor in Council:

1. The Chief Health Officer (an official member) – Dr Jeannette Young

2. The chairperson of the Trust (Trust abolished 01/02/11)

3. Two nominees of the National Health and Medical Research Council, at least one of whom has expertise in health research – Professor Judith Clements + one vacancy

4. One nominee of the senate of The University of Queensland – Vacant

5. One person with expertise in health research – Professor Lyn Griffiths

6. One medical practitioner with expertise in health research – Associate Professor Paula Marlton

7. One person with expertise in health research ethics – Professor Bryan Campbell

8. One lawyer – Mr Christopher Coyne

9. Two persons with expertise in financial management, business or public administration – Mr Paul Fennelly/ Professor John Hay (Chair)

All members of the QIMR Council are appointed for a three year term. If at the expiration of the term of office the member’s successor has not been duly appointed, the member shall hold office as a member of the Council until the member’s successor takes up office.


members of council

professor John Hay ac BA (Hons) (Western Australia and Cambridge), MA (Cambridge), PhD (Western Australia), Hon LittD (Deakin), Hon DLitt. (UWA); Hon DU (QUT), Hon LLD (Queensland), FAHA, FACE, FAIM, FQA

Professor Hay is Chair of QIMR Council.

Professor Hay was Vice-Chancellor of The University

of Queensland from 1996–2007. In that time, he led the development of many major new research institutes including the Institute for Molecular Bioscience and the Queensland Brain Institute. He was also instrumental in securing funding for the Translational Research Institute to be built at the Princess Alexandra Hospital.

Under his leadership, both Deakin University and The University of Queensland were named Australian Universities of the Year by the Good Universities Guide.

Professor Hay was appointed as Chair of QIMR by the Queensland Government in September 2009.

professor Bryan campbell AM MD BS FRACP FRACMA

Professor Campbell was formerly Chief Health Officer of Queensland and Head of The University of Queensland Medical School.

He has been a Councillor of the Royal Australasian College

of Physicians, the Royal Australian College of Medical Administrators and a member of the National Health and Medical Research Council (NHMRC). He was Deputy Chair of the Australian Health Ethics Committee and a member of the NHMRC Embryo Research Licensing Committee until June 2006.

Professor Campbell is the Chair of the QIMR Finance and Audit Committee.

professor Judith clements BAppSc MAppSc PhD

Professor Clements has over 20 years’ experience as a basic researcher in biomedical research, primarily in the general field of molecular endocrinology. Her current research seeks understanding of the molecular basis of hormone dependent

cancers such as prostate and ovarian cancer.

She is currently Scientific Director of the Australian Prostate Cancer Research Centre-Queensland and Program Leader of the Cancer Program within the Institute of Health and Biomedical Innovation at the Queensland University of Technology. She coordinates the Australian Prostate Cancer BioResource, a national tissue bank for prostate cancer research. She is also an NHMRC Principal Research Fellow and an NHMRC Academy member since 2009. In 2007 Professor Clements was awarded the prestigious international Frey-Werle Foundation Gold Medal for her significant contributions to the kallikrein protease field.

Professor Clements is Chair of the QIMR Appointment and Promotions Committee.

mr christopher coyne

Christopher Coyne is a solicitor of the Supreme Court of Queensland, an accredited specialist in the field of Commercial Litigation, specialising in insurance law, health law, corporate governance and risk management. Following his admission as a solicitor in 1979

he practised law in Brisbane and was a partner in the national law firm Clayton Utz from 1984 to 2004.

Mr Coyne now practices on his own account. He was appointed an Adjunct Professor of The University of Queensland School of Law in 2002. Chris is Board Chairman of Lexon Insurance Pte Ltd (Queensland Law Society, Singapore Captive Insurer), a Director of the Incorporated Council of Law Reporting for the State of Queensland, past president Medico-Legal Society of Queensland and Australian Insurance Law Association and former legal member Australian Health Ethics Committee. Christopher is a sessional member of the Queensland Civil and Administrative Tribunal and also a member of the QIMR Personnel Administration Committee.

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mr paul fennelly BA LLB

Paul Fennelly has wide experience in financial management, business and public administration. He is an executive with Hastings Funds Management, which is a member of the Westpac Group. His focus is on major equity investments, primarily

in social and economic infrastructure. From 2002–2006, Mr Fennelly was Director-General of the then Department of State Development; concurrently he served as Queensland’s Coordinator-General. Prior to joining the Queensland Government he was Victorian Director of the Australian Industry Group, which is the nation’s largest industry association. Mr Fennelly chaired the QIMR Finance and Audit Committee.

professor Lyn griffiths BSc (Hons) PhD

Professor Griffiths is Director of the Griffith Health Institute and the Genomics Research Centre at Griffith University. She has expertise in human molecular genetics, undertaking research to map and identify genes involved in common complex human disorders, including

studies on migraine, cardiovascular disease risk, multiple sclerosis and certain types of cancer. Her research has been well funded by national competitive grants and industry and she has authored more than 200 peer-reviewed publications to date in molecular genetics international journals as well as supervising 28 PhD students to completion. She is a current Queensland President Human Genetics Society Australasia, past ASMR Director, current Member and past Chair of the Scientific Program Committee for the International Congress of Human Genetics and has been awarded the Centenary Medal for Distinguished Service to Education and Medical Research. Professor Griffiths is a member of the QIMR Appointments and Promotions Committee.

associate professor paula marlton MB BS (Hons I) FRACP FRCPA

Paula Marlton is the Head of Leukaemia and Lymphoma Services at the Princess Alexandra Hospital where she is also Deputy Director of Haematology. Her previous appointments include three years at the MD Anderson

Cancer Centre in Houston, Texas. She has extensive experience in clinical research including the role of principal investigator for national multi-centre trials and supervisor of molecular translational research associated with trials. She was the founding Chair of the Australasian Leukaemia and Lymphoma Group (ALLG) Laboratory Science Committee and has established and continues to direct the ALLG Tissue Bank. Her other professional roles include Medical Advisor and Board member of the Leukaemia Foundation, member of several Drug Advisory Boards and Government and College Advisory Committees as well as a wide range of academic and clinical service roles.

Dr Jeannette Young MB BS FRACMA AFACHSE

Dr Jeannette Young is the Chief Health Officer for Queensland, a role she has filled since August 2005. Prior to this, she held the position of Executive Director of Medical Services at the Princess Alexandra Hospital in Brisbane and has previously worked in a range of positions

in Queensland and Sydney. She has specialist qualifications as a Fellow of the Royal Australasian College of Medical Administrators and as a Fellow by Distinction of the Faculty of Public Health of the Royal Colleges of Physicians of the United Kingdom. She is an Adjunct Professor at Queensland University of Technology and at Griffith University.

Today she is responsible for such matters as health disaster planning and response, aero-medical retrieval services, licensing of private pospitals, organ and tissue donation services, provision of health services to prisoners, cancer screening services, communicable diseases, environmental health and other population health services and mental health, alcohol and other drugs policy and legislation.

Along with sitting on the QIMR Council, Dr Young is a member of numerous State and National committees and Boards, some of which include the Queensland Board of the Medical Board of Australia, NHMRC, the Australian Health Protection Committee, the Clinical Technical Ethical Principal Committee of Australian Health Ministers’ Advisory Council, the Australian Population Health Development Principal Committee and the newly created Australian National Preventive Health Agency Advisory Council.

members of council | continued

Population Health Development Principal Committee and the newly created Australian National Preventive Health Agency Advisory Council.newly created Australian National Preventive Health Agency Population Health Development Principal Committee and the newly created Australian National Preventive Health Agency


committees to council

finance and audit committee

The primary objective of the Finance and Audit Committee is to assist QIMR Council in fulfilling its responsibilities relating to financial planning, policy and performance of QIMR.

The Finance and Audit Committee has observed the terms of its charter and has due regard to Queensland Treasury’s Audit Committee Guidelines.

• Mr Paul Fennelly (Chair to 23/02/11)

• Professor Bryan Campbell (Chair from 23/02/11)

• Mr Rodney Wylie

• Professor John Hay

appointments and promotions committee

The Appointments and Promotions Committee (APC) assists Council with the maintenance of academic standards at QIMR by reviewing all proposals for the appointment and promotion of Faculty staff.

• Professor Judith Clements (Chair)

• Professor Graham Brown

• Professor Julie Campbell (Chair for the Senior Research Officer APC, a subset of the APC)

• Professor Lyn Griffiths

• Professor James McCluskey

• Dr Jurgen Michaelis

• Professor Joe Trapani

• Professor Adèle Green (ex officio) (From 01/07/10 to 04/01/11)

• Professor Frank Gannon (ex officio) (From 04/01/11)

investment committee

The Investment Committee is responsible for overseeing the investment of QIMR Council funds.

• Mr Rodney Wylie (Chair)

• Mr Bruce Phillips

• Mr Michael Sargent (From 08/08/10)

Human research ethics committee

The Human Research Ethics Committee (HREC) on behalf of Council ensures the maintenance of ethical standards in research and compliance with regulatory guidelines.

• Dr Ian Wilkey (Chair)

• Dr Roger Allison

• Ms Madeline Brennan

• Mrs Gwen Eardley

• Mr Angus Edmonds

• Mr Colin Forrest (To 01/02/11)

• Mrs Mary Mackenzie

• Mr David Russell

• Dr Christopher Schmidt (To 14/06/11)

• Mr John Stead

• Associate Professor Katharine Trenholme

• Dr Tom Sculley

• Ms Donna Hancock

• Dr Agnieszka Mitchell (ex officio)

• Ms Nicola Yu – Secretary (From 01/07/10)

animal ethics committee

The QIMR Animal Ethics Committee (AEC) on behalf of Council ensures the maintenance of ethical standards in research and compliance with regulatory guidelines.

the Smart State medical research Steering committee (to 22/09/10)

The Smart State Medical Research Steering Committee (SSMRSC) on behalf of Council oversees the development of the Smart State Medical Research Centre Project.

• Professor John Hay (Chair)

• Mr Rodney Wylie

• Mr John Parnell

• Mr Alan Stockman

• Ms Rosemary Hood

• Dr Rick Andrew

• Ms Karen Thompson


• Ms Beatrix Wanrooy – Secretary

the Smart State medical research committee (from february 2011)• Professor Frank Gannon (Chair)

• Professor Adèle Green

• Mr Alan Stockman

• Mr John Parnell


• Dr Joseph Pereira

• Ms Beatrix Wanrooy – Secretary

risk managementThe review and management of risk at QIMR is undertaken by QIMR Council through the Finance and Audit Committee. Through the Finance and Audit Committee, QIMR management have developed a register of potential risks applicable to functions of the Institute. A schedule of quarterly reviews incorporates the actions required to improve any identified gaps in controls.

The review process will record all incidents reported to Committees, Management or Council and allocate those incidents to risk categories. If a risk has not previously been described in the register, it will be added in the appropriate category and controls developed. category and controls developed.

Dr Christopher Schmidt (To 14/06/11)

Mr David Russell

Dr Christopher Schmidt (To 14/06/11)

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audit committeeThe primary objective of the Finance and Audit Committee is to assist QIMR Council in fulfilling its responsibilities relating to financial planning, policy and performance of QIMR with the following prime objectives:

• Sound financial planning and management processes;

• Low level financial and business risk;

• Establish guidelines for the financial budgeting process;

• Processes to manage variations to budget;

• Measure financial performance against budget, including the establishment of provisions and write-offs;

• Internal controls to establish exposure to business risk and fraud;

• Effective and adequate accounting, administrative, operating and delegation policies;

• Responsive management actions to accounting reports produced by external and internal auditors;

• Policies to avoid conflicts of interest for past, present and future transactions between QIMR and staff;

• Policies and procedures to ensure QIMR complies with Federal, State and local government legislation;

• Ethical approaches to QIMR’s policies and practices.

The Committee meets quarterly to review business and financial risk, financial operating performance and audit performance. The Committee reviews all issues and recommendations arising from internal audit and Queensland Audit Office, along with agreed management action implemented to address any issues found.

The Finance and Audit Committee has observed the terms of its charter and has due regard to Queensland Treasury’s Audit Committee Guidelines. The Finance and Audit Committee comprises:

• Mr Paul Fennelly (Chair until 23/02/11)

• Professor Bryan Campbell (Chair from 23/02/11)

• Mr Rodney Wylie

• Professor John Hay

Committee members are paid $167 (Chair) or $141 (member) per meeting, up to four hours per meeting.

internal auditThe role of Internal Audit is to provide the Finance and Audit Committee and QIMR Council with independent, objective assurance and advice designed to add value and assist QIMR in accomplishing its objectives by bringing a systematic, disciplined approach to evaluating and improving the appropriateness and effectiveness of risk management and internal control. Internal audit is a fundamental part of corporate governance that ensures that the organisation operates effectively, efficiently and economically. The Finance and Audit Committee acts as a forum to oversee the planning, performance and reporting of the Internal Auditor.

The internal audit contractor (KPMG) met with the Finance and Audit Committee on the following occasions during

the period 1 July 2010 – 30 June 2011: 27 August 2010, 26 November 2010, 25 February 2011 and 10 June 2011.

The approach taken to identifying areas of significant risk combines a focus on both cyclical reviews of core business processes as well as reviews of key risk areas. KPMG’s integrated Governance, Risk and Controls (GRC) Framework builds on a traditional internal audit model to take a holistic view of QIMR’s key objectives, risks, controls and supporting structure across the organisation.

In formulating an internal audit plan for presentation to the Finance and Audit Committee for approval, consideration is given to past internal audit findings, recent and forthcoming changes in systems and processes, key business risks and the period since the last internal audit of each core business process. Annual internal audit plans are prepared and presented to the Finance and Audit Committee prior to the commencement of each financial year.

The internal audit function has observed the terms of its charter and has due regard to Queensland Treasury’s Audit Committee Guidelines.

external ScrutinyQIMR was not subject to any reports of any parliamentary committees, the Crime and Misconduct committee or the Queensland Ombudsman.

Whistleblowers protection act 1994No public interest disclosures were received during the 2010–2011 reporting year.

information systems and recordkeepingQIMR maintains full and accurate records of its activities in accordance with the Public Records Act 2002, Information Standard 40 and Information Standard 31. The QIMR Recordkeeping Policy 2008 was established and adopted to provide an organisation-wide policy on the management of documents and records, both hardcopy and electronic.

QIMR has implemented a single, official records and electronic document management system called Total Records and Information Management (TRIM) Context. The implementation of TRIM Context has enabled QIMR to maximise the value of records with consistent and timely capture. It also improves accessibility, reduces duplication and promotes information-sharing across the organisation.

Records are not disposed of, or archived, unless their disposal is authorised under the Public Records Act 2002 or by reference to the Retention and Disposal Schedule approved by the Queensland Studies Authority (QSA). All QIMR records are registered into TRIM Context before transfer to the off-site storage provider or QSA. All QIMR hardcopy records stored off-site are managed under legislatively appropriate risk management standards and guidelines.

The internal audit contractor (KPMG) met with the Finance and Audit Committee on the following occasions during and Audit Committee on the following occasions during The internal audit contractor (KPMG) met with the Finance and Audit Committee on the following occasions during

off-site are managed under legislatively appropriate risk management standards and guidelines. management standards and guidelines. off-site are managed under legislatively appropriate risk management standards and guidelines.


our management

executive management Director and CEO, Professor Frank Gannon

Professor Frank Gannon is QIMR’s seventh Director and CEO. In that role he is responsible for the research work undertaken by the Institute and management of our employees, under the overall control of the Council. Professor Frank Gannon joined QIMR as Director and CEO in January 2011.

Previously, Professor Gannon was the Director General at Science Foundation Ireland (SFI) from 2007.

From 1994–2007, Professor Gannon was the Executive Director of the European Molecular Biology Organisation (EMBO) and Senior Scientist at the European Molecular Biology Laboratory (EMBL), based in Germany; and Director of the National Diagnostic Centre and Associate Professor in the Department of Microbiology at University College Galway, Ireland (1981–1994).

He obtained a Bachelor of Science from the National University of Ireland, Galway in 1970, a PhD from the University of Leicester, England in 1973, was a post-doctoral fellow at the University of Madison Wisconsin, USA from 1973 to 1975, and Chargé de Recherche in INSERM at the University of Strasbourg, France from 1975 to 1981, when he returned to Galway.

His major research interest is the expression and functional regulation of the oestrogen receptor, which plays a major role in breast cancer and osteoporosis. These studies have provided leads to novel treatments or therapeutic approaches to these and other cancers.

Professor Gannon has authored over 200 research articles published in international journals. In addition, from 2000–2008, he contributed to a monthly editorial to EMBO Reports of which he was founding Senior Editor and also writes extensively on diverse topics related to science policy. Professor Gannon has seven patent applications, four of which are active and was the founder of both Bimini Ltd (1990) and Elara Pharmaceuticals (2006). He was a member of the interim Board of Science Foundation Ireland from 2002 to 2004 and was elected as a Member of the Royal Irish Academy in May 2008.

He has been awarded honorary Doctorates by the University of Jozsef Attila Szeged (Hungary), The University of Queensland and Queens University Belfast (Northern Ireland).

He has served on a range of high-level scientific advisory boards at institutes throughout the world and was co-founder of the European Life Sciences Forum (ELSF) and the Initiative for Science Europe (ISE) that played significant roles in the establishment of the European Research Council (ERC).

He was Vice President of the European Heads of Research Council and an advisor to the European Union Commissioner for Research and Innovation prior to his move to Brisbane.

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management advisory group (mag) membership

Program/Department

Director: Professor Frank Gannon

Deputy Director: Professor Adèle Green

Chief Operating Officer: Ms Donna Hancock

Program Coordinators: Professor Georgia Chenevix-Trench Cancer

Professor James McCarthy Infectious Diseases

Professor Michael Breakspear Mental Health/Complex Disorders

Department Coordinators: Professor Geoff Hill Immunology

Professor Emma Whitelaw Cell and Molecular Biology

Professor Grant Montgomery Genetics Computational Biology

Professor David Whiteman Population Health

Professor Denise Doolan Biology

Secretary: Ms Nerida Fox

Standing left to right: Professor Emma Whitelaw, Professor Geoff Hill, Professor Grant Montgomery, Professor James McCarthy, Professor Michael Breakspear, Professor Denise Doolan, and Professor David Whiteman Sitting left to right: Professor Adèle Green, Professor Frank Gannon, Ms Donna Hancock Absent: Professor Georgia Chenevix-Trench


Adèle Green AC MBBS MSc PhD

Deputy Director, QIMR Head, Cancer and Population Studies Group, QIMR

Adèle Green is the Deputy Director of QIMR and Head of QIMR’s Cancer and Population Studies Group. She has served on national and international health

and research committees including the NHMRC, and the Scientific Council of the International Agency for Research on Cancer. She is currently a member of the International Commission on Non-Ionising Radiation Protection and its Epidemiology Standing Committee. In 2004, Professor Green was awarded a Companion of the Order of Australia (AC) for “Service to medical research to public health including improved Indigenous health, and for leadership in the wider scientific community”.

Georgia Chenevix-Trench BA (Hons) BSc PhD

NHMRC Senior Principal Research Fellow Coordinator, Cancer Program, QIMR Head, Cancer Genetics Laboratory, QIMR

Georgia Chenevix-Trench is a NHMRC Senior Principal Research Fellow and Head of

the Cancer Genetics Laboratory at QIMR. She is also the conjoint Professor in the Division of Health Sciences at The University of Queensland. She holds a BA (Hons) from the Department of Genetics at Trinity College in Ireland, and was awarded a PhD in 1985 from the Department of Human Genetics at the Medical College of Virginia, USA.

Her current research focuses mainly on the study of genes that predispose stomach, breast and ovarian cancers, and genes involved in response to chemotherapy in ovarian cancer patients. She has played a leading role in national efforts to establish resources for this kind of research, and is involved in many international consortia aimed at coordinating these gene finding efforts.

She possesses an impressive national and international profile, with invitations to speak at many high profile conferences.

She was the Sutherland Lecturer at the International Congress of Human Genetics in 2006.

She has received funding from many national and international grant funding bodies, and published more than 200 papers in peer reviewed journals.

Grant Montgomery BAgSc (Hons) PhD

Coordinator, Genetics Department, QIMR Coordinator, Computational Biology Department, QIMR Head, Molecular Epidemiology Laboratory, QIMR

Professor Montgomery graduated with a PhD from Massey University, Palmerston

North in 1977 and spent the first 20 years of his career working in animal reproduction and genetics in New Zealand. He trained in endocrinology, including two years as a post-doctoral fellow at the Institute National de la Researches Agronomique, Tours, France. After returning to New Zealand, he set up a genomics laboratory located in the Biochemistry Department at the University of Otago and helped build the first sheep genetic map and mapped and cloned genes affecting twinning frequency.

He moved to QIMR in 1999 and is currently an NHMRC Principal Research Fellow, Head of the Molecular Epidemiology Laboratory, Coordinator of the Genetics Division at QIMR, and a co-leader of the International ENDOGENE Consortium. The goal of Professor Montgomery’s research is to determine critical genes and pathways increasing risk for common diseases, with specific interests in the genetics of endometriosis, melanoma and inflammatory bowel disease.

Emma Whitelaw BSc (Hons) PhD

NHMRC Australia Fellow Coordinator, Cell and Molecular Biology Department, QIMR Head, Epigenetics Laboratory, QIMR

Emma Whitelaw is an NHMRC Australia Fellow at QIMR. After completing her undergraduate degree at the Australian

National University, she obtained a Doctor of Philosophy at the University of Oxford and remained working in London and Oxford for the next 15 years, moving back to Australia in 1991. She was offered a Senior Lectureship at the University of Sydney and carried out both teaching and research. She has focused her research on eukaryotic transcription using the mouse as a model organism. Her most notable research achievements are in the area of epigenetics. In particular, her studies on the transgenerational inheritance of epigenetic marks have stimulated a great deal of interest from the wider scientific community. In 2008, she was awarded an Australia Fellowship, the most prestigious fellowship in medical research in Australia.

In 2011 Professor Whitelaw, was elected as an Australian Academy of Science Fellow, and received both the Australia and New Zealand Society for Cell and Developmental Biology President’s Medal and the International Union of Biochemistry and Molecular Biology Jubilee Medal.

Page 29

James McCarthy MBBS MD FRACP DHTM

Coordinator, Infectious Diseases Program, QIMR Head, Clinical Tropical Medicine Laboratory QIMR Senior Consultant Infectious Diseases Physician, RBWH Professor of Medicine, The University of Queensland

After graduating in Medicine from the University of Melbourne in 1984, James McCarthy undertook postgraduate training in Internal Medicine and Infectious Diseases in Australia, the UK and the USA. He then undertook research training in molecular parasitology at the Laboratory of Parasitic Diseases, NIH (1991–1996), graduating as a Doctor of Medicine in 1997. He returned to Australia in 1996 to take a post in the Department of Medicine at the University of Western Australia, before moving to QIMR in 2002. At QIMR his research focuses on translational aspects of vaccines, drugs and diagnostics in tropical diseases. James is an NHMRC Practitioner Fellow and Queensland Health Research Fellow. He serves on the Editorial Board of the American Journal of Tropical Medicine, the International Journal of Parasitology and as Associate Editor of PLoS Neglected Tropical Diseases. His laboratory includes a multidisciplinary team of scientists undertaking bench research, a regulatory affairs specialist in clinical trial management, and staff and students undertaking epidemiologic studies and clinical research. Sources of research funding include competitive grants from NHMRC, Medicines for Malaria, and Queensland Health, and the World Health Organization.

Geoff Hill MBChB MD BHB FRCPA FRACP

NHMRC Australia Fellow Coordinator, Immunology Department, QIMR Head, Bone Marrow Transplantation Laboratory, QIMR

Geoff Hill is a medical graduate of the University of Auckland and haematologist, training in

New Zealand, The Dana Farber Cancer Institute, and Harvard Medical School in Boston. He is a NHMRC Australia Fellow and his immunology laboratory focuses on the interactions between cytokines, antigen presenting cells and regulatory cells during transplantation. Professor Hill was 2005 Queenslander of the Year and recipient of the Transplantation Society of Australia and New Zealand 2009 Ian McKenzie Award for excellence within basic and clinical research in the transplant field. He was also awarded a Queensland Health Senior Clinical Research Fellowship in 2010 to translate new therapies into clinic practice; and in 2011 received a prestigious NHMRC Australia Fellowship worth $800,000 annually for five years.

Michael Breakspear BSc (Med Hons) BA (Hons) MBBS PhD FRANZCP

Coordinator, Mental Health/Complex Disorders Program, QIMR Head, Systems Neuroscience Laboratory, QIMR

Michael Breakspear undertook undergraduate studies at the University of Sydney,

graduating in 1994 with Honours in Arts, Science and Medicine. Following three years of basic medical residency, he commenced training in clinical psychiatry at St Vincent’s Hospital, Sydney, and a concurrent PhD at the University of Sydney. After completing post-doctoral fellowships in Physics at the University of Sydney and the Black Dog Institute, he became an Associate Professor in Psychiatry at the University of New South Wales in 2006. He accepted the position of Head of a new Division of Mental Health Research at QIMR in 2008. This division aims to add the latest advances in neuroscience to the Institute’s internationally renowned expertise in genetics, cell biology and population health. He has also completed his clinical training and is a Fellow of the Royal Australian and New Zealand College of Psychiatrists.

Michael’s expertise lies in both computational and experimental neurosciences. He has made theoretical, methodological and empirical contributions in a “system’s neuroscience” framework that sees the brain as a complex, dynamical network. His interests are in the application of this framework to underpin a novel generation of diagnostic brain imaging tests in clinical psychiatry. He is a chief investigator on a number of major national and international grants totalling approximately $8 million and leads an independently funded research team of 10 young students and scientists. He is a Section Editor at NeuroImage, a major international brain imaging journal.

Donna Hancock BCom MBA MAICD

Secretary and Chief Operating Officer, QIMR

Donna Hancock is the Chief Operating Officer, Secretary to QIMR Council and heads the Corporate Division. She holds a Bachelor of Commerce from Newcastle University and a Masters in Business

Administration from the University of Melbourne. She has an extensive background in finance, business planning, business development, systems development and commercial management. Prior to joining QIMR, Donna worked for over 20 years as a senior executive with BHP Billiton.

Donna is a director of Q-Pharm Pty Ltd, a member of the Medical Board of Australia (Qld Registrations Committee) and a former member of the Pharmacists Board of Queensland.

management advisory group (mag) membership | continued

annually for five years. Medical Board of Australia (Qld Registrations Committee) and a former member of the Pharmacists Board of Queensland.a former member of the Pharmacists Board of Queensland.Medical Board of Australia (Qld Registrations Committee) and a former member of the Pharmacists Board of Queensland.


David Whiteman BMedSc MBBS (Hons) PhD FAFPHM

Australian Research Council Future Fellow Coordinator, Population Health Department, QIMR Head, Cancer Control Laboratory, QIMR

David Whiteman is a medical epidemiologist with a special interest in the causes, diagnosis,

prevention and treatment of cancer. He received his medical degree from The University of Queensland in 1991. With a PhD in cancer epidemiology at QIMR (1997) and specialist training in Public Health Medicine, David was invited to the University of Oxford as a Nuffield Medical Research Fellow to work in several areas of cancer research. He returned to Queensland in 2000, where he is currently studying the causes of melanoma and diseases of the oesophagus, ovary and skin.

In addition to his research activities, he is currently a member of the Academy of the NHMRC, the National Research Advisory Committee for Cancer Australia, the Research Committees of Cure Cancer Australia Foundation and Wesley Research Institute, and the Fellowships Committee of the International Agency for Research on Cancer. He has previously served as a Member of Council of NHMRC, and served on the NHMRC National Asbestos Research Working Group and the NHMRC Strategic Research Development Committee. In 2006, he was awarded a Fulbright Scholarship to visit cancer researchers in the USA.

Denise Doolan BSc (Hons) MPh PhD

Pfizer Australia Research Fellow, 2007–2011 Coordinator, Biology Department, QIMR Head, Molecular Vaccinology Laboratory, QIMR

Denise Doolan graduated from The University of Queensland with a Bachelor of Science

(Honours) (Biochemistry major) in 1985. She began her research career at the CSIRO and was subsequently awarded an MPhil in 1991. In 1993, she completed her PhD in the laboratory of Professor Michael Good at QIMR and went on to complete a postdoctoral fellowship at the Naval Medical Research Institute in the USA where she worked with Dr Stephen Hoffman to develop malaria vaccines. She was later appointed as Head of Basic Research, and later Head of Preclinical Research and Development, and finally as Scientific Director of the Naval Medical Research Center Malaria Program, a major biomedical research facility of the United States Department of Defence. Professor Doolan returned to Australia in 2006 and was awarded a Pfizer Australia Senior Research Fellowship, establishing the Molecular Vaccinology Laboratory at QIMR in 2007. Subsequently, she was appointed as Professor, Griffith Medical Research College, Griffith University, and as Professor, School of Medicine, The University of Queensland. Her laboratory investigates the molecular basis of immunity to disease and vaccine development, with a focus on malaria.

Page 31

ouR peRFoRmAnCe

Translation

Scientific quality

Commercial consequence

Societal impacts

International reputation

Page 33

In order to improve the health of all, scientific discoveries need to be translated from the laboratory into the clinic. QIMR was the prototype of what is, today, referred to as a translational medical research institute. It is one of Australia’s only fully integrated biomedical research and development centres.

Translational research undertaken at QIMR has lead to the development of a T cell therapy for EBV-associated nasopharyngeal carcinoma; influenced a major change in clinical practice with the acceptance that it is important to remove proximal serrated polyps; and human clinical trials are underway using a monoclonal antibody developed at QIMR for the teatment of acute leukaemias, melanomas, brain tumours and lung cancers.

Translation

translation facilitiesQIMR is one of Australia’s only fully integrated biomedical research and development centres. Within the Institute, there is the capability to translate fundamental basic research from the discovery phase through development, scale-up and manufacture, to Phase I and II clinical trials.

QIMR also has facilities for the manufacture of cell-based and molecular therapies. Co-located within the Institute is an associated commercial Phase I/II clinical trials facility, Q-Pharm Pty Ltd, providing QIMR scientists and external clients the capability to take research findings from bench to the bedside.

Q-gen

Q-Gen is licensed by the Therapeutic Goods Administration (TGA) for the maintenance and storage of working cell banks, the storage on site of cellular products. The TGA license makes Q-Gen one of a very small number of organisations in Australia able to store human samples under GMP conditions.

Q-Gen is one of the largest facilities of its type in Australia, with 13 ISO Class 7 clean rooms. Each clean room is fully equipped for the manufacture of clinical therapies.

Q-Gen provides QIMR with a unique facility to conduct its translational research and processes for clinical therapies and is currently utilised in the manufacture of a number of QIMR sponsored developmental immunotherapies. Under a joint funding agreement with Therapeutic Innovation Australia (formerly Research Infrastructure Support Services) and the Australian Red Cross Blood Service, Q-Gen is able to manufacture clinical trial products for eligible external researchers.


Q-pharm

Q-Pharm is a specialist contract research organisation that conducts early phase clinical trials of pharmaceutical and biotechnology products spanning the areas of therapeutic, diagnostic and disease prevention agents.

In order to facilitate the translation of QIMR’s research into clinical practice, QIMR holds a 24.5% share in Q-Pharm.

The company offers the best appointed early phase clinical trials facilities in Australasia, which include recruitment and outpatient clinics, a specialised 18-bed clinic for the conduct of the most medically demanding trials and an open plan 24 bed facility for larger healthy volunteer trials.

clinical collaborations Because of its close proximity to major teaching hospitals and The University of Queensland Medical School, QIMR is ideally placed for clinical research collaborations. It has a proud history of working closely with hospitals, in particular the RBWH. Clinicians have research groups in QIMR and medical researchers in QIMR have clinical sessions at the RBWH. QIMR’s researchers also have significant relationships with clinicians nationally and internationally. Last year, 64% of QIMR researchers collaborated with clinicians in over 100 projects, in hospitals worldwide.

Some of QIMR’s current clinical collaborations include:

• Collection of samples from cystic fibrosis, glioma, ataxia-telangiectasia, melanoma and oesophageal cancer patients for genetic, tissue and cell culture studies (Prince Charles Hospital, BrizBrain and Spine, Wesley Hospital, RBWH, Greenslopes Hospital, St Vincent’s Hospital, Murdoch Children’s Research Institute, Royal Brisbane Children’s Hospital, Princess Alexandra Hospital);

• Recruitment of patients into national tissue and data bank (Flinders University, University of New South Wales);

• Looking at the effect of advanced paternal age on risk of autism or schizophrenia (Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Brain Research Institute);

• Assessing disease risk in patients with haemochromatosis (Royal Children’s Hospital Melbourne, University of Western Australia, RBWH);

• Investigating the role of Epstein-Barr virus in multiple sclerosis (RBWH);

• Ongoing collection of samples of diffuse large B cell lymphoma (Westmead Hospital, Princess Alexandra Hospital);

• Developing a model for scabies to study the interaction between scabies mite and bacterial infection (RBWH, Royal Darwin Hospital); and

• Identifying serum and tissue biomarkers to predict outcome in biliary atresia and cystic fibrosis liver disease (St Louis Children’s Hospital, St Louis and Washington University).

In 2010–2011, QIMR’s clinical collaborations have produced a range of significant outcomes:

• Helped better identify patients at high risk of developing primary melanoma;

• Identified a novel oncogene in asbestos-related lung cancers;

• Identified a microRNA that appears to suppress lung cancer development;

• Discovered that major depression consists of multiple partly overlapping subtypes and bipolar depression, in comparison to unipolar depression, has a distinct clinical profile;

• Discovered that working memory-related cortical activity predicts functional decline in people with mild cognitive impairment; and

• Showing that patients with haemochromatosis are at increased risk of colon and breast cancer.

Drug discoveryThe discovery of small molecules or related agents, reveal new insights and new biological pathways, which may ultimately lead to the development of therapeutics for a range of human diseases.

Examples of drug discovery projects currently underway at QIMR include screening for:

• Small molecules that might inhibit or enhance membrane iron transport, or that interfere with the action of iron regulatory molecules such as hepcidin (implications for disorders of iron metabolism);

• Drugs that convert hepatic stellate cells to myofibroblasts or reverse the conversion (implications for therapeutic intervention in chronic liver disease);

• Modifiers of p53 regulation, in cell lines where novel proteins involved in the regulation of p53 have been deleted (implications for cancer treatment);

• Antimalarial (antigametocyte) drugs;

• Novel compounds to improve the efficacy of malaria vaccines, especially compounds that stimulate a robust cell mediated immune responses to malaria in vivo;

• Compounds that affect the immune system (immunomodulators);

• Protease inhibitors in malaria;

• Antibacterials, especially against group A streptococcus;

• Activators or inhibitors of ATM kinase to target DNA damage pathways in cancer;

• Synergistic modulators of pathways in breast cancer cells;

• Inhibitors of MIC-1 transcription in reporter cancer cells; and

• Inhibitors of HIV-1 Tat medicated transactivation using a dual luciferase cell based assay in order to develop a treatment for HIV.

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QIMR’s fundamental research has lead to the development of a potential cancer therapy.

EBC-46 is a novel and highly potent compound in development for local treatment of solid tumours. Research by QIMR’s Professor Peter Parsons from the Drug Discovery Laboratory has assisted in this compound being further developed by QBiotics.

EBC-46 has potential applications for skin cancers including melanomas, squamous cell carcinomas (SCC) and basal cell carcinomas (BCC); head and

neck cancers and other solid tumours where injection can be guided by imaging.

Although only in late pre-clinical development for humans, QIMR and QBiotics have conducted studies in laboratory cell culture and in mice. They have also successfully treated dogs, cats and horses with advanced spontaneous tumours that were considered untreatable with current standards of care.

QIMR researchers continue to uncover the mode of action of this compound to develop analogues and other potential anti-cancer therapies.

QIMR’s fundamental research has led to the development of a potential cancer therapy

Vaccine developmentThe Australian Centre for Vaccine Development (ACVD) at QIMR is one of the largest vaccine research centres in Australia. It provides opportunities for its members to develop collaborative links with national and international academic institutions and the biotechnology industry and also provides a platform for young Australian and international scientists to develop new techniques in the field of vaccine research.

ACVD is collaborating with internationally renowned Emory Vaccine Centre (EVC) Atlanta, USA under the Queensland Government funded National and International Smart State Research Program (Queensland-US Vaccine Technology Alliance) to explore new technologies that can be used to develop and improve vaccines.

Both organisations have strong links with the biotechnology industry and health institutions that are being leveraged to translate the outcomes of research from bench to bedside, which will have significant implications for improving health outcomes for Australians. This collaborative program is also aiming to bring new technologies to Queensland and create training and employment opportunities for Queenslanders.

ACVD has unique expertise and resources in antigen discovery with a strong focus on immunomics, bioinformatics and high throughput re-sequencing. This approach allows rapid whole genome scanning of infectious pathogens and cancer antigens to map novel vaccine determinants.

The major achievements for the ACVD include:

• Completion of in vitro screen of natural products library as immune adjuvants capable of activating innate immunity;

• Completion of Phase I of clinical testing of novel immunotherapy for nasopharyngeal carcinoma patients;

• In vivo immune analysis of natural products identified through in vitro screen with primary objective to identify the most promising candidates for further research;

• Establishment of collaborative links with international biotechnology companies on the development and testing of a vaccine to prevent birth defects in newborn babies;

• Initiation of project aiming to conduct gene signature analysis of potential immune adjuvants identified using natural product library;

• Development of strategies to revert the dysfunctional cellular and humoral anti-viral response (e.g. targeting of PD-1); and

• Establishment of collaborative studies with RBWH and BrizBrain and Spine (Wesley Hospital) to test novel killer T cell therapy for stem cell transplant and brain cancer patients respectively;

current clinical trialsFundamental research at QIMR in 2010–2011 underpinned a number of clinical trials that may ultimately lead to improved treatment options for patients. Some highlights include:

• Began Phase I clinical trials using a monoclonal antibody as a potential cancer treatment for acute leukaemias, melanomas, brain tumours and lung cancers;

• Completed a human malaria infection study to develop a sensitive protocol for testing new antimalarial drugs;

• Completed an EBV immunotherapy trial;

• Developed a killer T cell therapy for EBV-associated nasopharyngeal carcinoma;

• Completed the preclinical testing of a prophylactic vaccine for cytomegalovirus. A Phase I clinical trial is planned for this vaccine, which aims to prevent clinical complications in transplant patients and newborn babies;

• Continued trialling a novel immunotherapy for brain cancer; and

• Started a clinical trial of a novel immune-based diagnostic tool for cytomegalovirus.

other potential anti-cancer therapies.


QIMR’s philosophy is to support scientists who perform world-class medical research aimed at improving the health and well being of all people.

QIMR has demonstrated scientific quality in a number of ways in 2010-2011 including producing 567 peer reviewed publications, securing more than $21 million of competitive NHMRC funding, as well as producing a range of world-class research outcomes across its 50 laboratories.

QIMR will continue to strive for the highest standard of scientific quality by attracting outstanding researchers; producing and contributing to publications and high-impact publications; and gaining ongoing support from funding bodies to continue our medical research.

publicationsPublications and citations are a key indicator of achievement and excellence in academic research and are a core output of QIMR. Confirming our ongoing pursuit of excellence in science, researchers at QIMR contributed to 567 scientific publications; a significant increase on 390 publications in 2009–2010 and 419 in the 2008–2009 financial year.

Not only have the number of publications increased but at the same time the quality of the research has improved. Of these 567 publications, 61 were published in very high impact journals (those with an impact factor over 10); compared to 55 in 2009–2010, and 42 in 2008–2009.

For a full list of publications, see page 133.

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This year, QIMR researchers been published in a range of high impact scientific journals such as Science, Nature and Nature Genetics. These include articles on:

• the genetics of breast and ovarian cancer, migraine, myopia (short or long sightedness), open angle glaucoma, endometriosis, ulcerative colitis, height, and personality traits (Nature Genetics);

• DNA damage and repair mechanisms in Science;

• the genetics of human height and new genes associated with blood lipids, a key indicator of heart disease (Nature);

• training T cells to fight malaria (Nature Medicine);

• diagnosing and treating schistosomiasis, a parasitic disease that affects 207 million people worldwide (British Medical Journal (BMJ) and Lancet Infectious Diseases); and

• papillomaviruses and the number of cases of non-melanoma skin cancer (BMJ).

fundingQIMR was recognised and gained support for our innovative work, with researchers securing more than $21 million in funding from the National Health and Medical Research Council (NHMRC).

Funds were provided from 1 January 2011 for a total of 17 new research projects ranging from the genetics of brain structure and function, to understanding the causes of breast and ovarian cancer and risks, to improving the health of Indigenous populations.

nHmrc grants awarded ($ millions)

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employmentEnsuring the ongoing quality of research, QIMR employed 17 NHMRC Fellows in 2010–2011.

invited lecturesQIMR researchers are well respected throughout Australia and the world and were invited to speak about their work at over 340 lectures in 2010–2011, including:

• Associate Professor Don Gardiner presenting at the Medicines for Malaria Venture ESCA Meeting in Geneva in October 2010;

• Professor Denise Doolan presenting at the International Congress of Parasitology in Melbourne in August 2010;

• Professor Grant Montgomery discussed the genetics of endometriosis at the Society for Gynaecological Investigation in Miami in March 2011; and

• Professor Jeff Gorman spoke at the Australian Proteomics Society in Lorne in February 2011.

For a full list of invited lectures, see page 112.

awardsInstitute staff members also received over 90 local and international awards in the last financial year, including:

• Professor Emma Whitelaw, Head of the Epigenetics Laboratory, was elected as an Australian Academy of Science Fellow, and received both the Australia and New Zealand Society for Cell and Developmental Biology President’s Medal and The International Union of Biochemistry and Molecular Biology Jubilee Medal;

• Professor Geoff Hill receiving an Australian Fellowship. Australian Fellowships are the most prestigious of the NHMRC fellowships and awards, with only six awarded this year. They are designed to support the most outstanding and creative health and medical researchers across the range of disciplines in biomedical, clinical, health services and public health research and are highly competitive among leading researchers both in Australia and around the world.

• Professor Don McManus, Professor Rajiv Khanna and Dr David Duffy received Senior Principal Research Fellowships from the NHMRC;

• Dr Darren Gray was awarded Publication of the Year by Griffith University;

• Dr Susan Woods received the Queensland Senior Researcher Award from the Australian Society for Medical Research;

• Dr Patricia Valery, from the Indigenous Health Program, was awarded a NHMRC Excellence Award, the highest ranking Career Development Award in the category of population health; and

• Dr Sarah Medland from the Genetic Epidemiology Laboratory was awarded a 2010 Queensland Young Tall Poppy Science Award.

For a full list of awards, see page 111.


postgraduate studentsToday’s students are the scientists of the future, so in order to ensure the continuation of the Institute’s scientific quality, postgraduate students are an important part of the research effort at QIMR. The excellent research facilities, support services, extensive network of international and national research collaborations, and the internationally-ranked quality of QIMR scientists, combine to provide an outstanding environment for advanced training in health and biomedical research. Mentoring of the students remains a high priority.

2010–2011 was again a productive year for students at QIMR with a total of nine PhD students, five Research Masters and 10 Honours students successfully graduating from their degree programs. During the year, the Institute admitted 17 new PhD, two Research Masters, two coursework Masters and 20 Honours students. Janine Whitney joined the Institute under the Australian Government’s Indigenous Cadetship Program. QIMR also hosted 43 visiting students during the year, many from overseas.

QIMR’s postgraduate students have continued to make an impressive impact on the wider scientific community this year with many receiving external awards during their candidature. Highlights include:

• Renee Robb, a third year PhD student, was awarded a Young Investigator Award and the President’s Prize from the Transplantation Society of Australia and New Zealand;

• Karin Verweij received a Research Excellence Award from the School of Psychology at The University of Queensland; and

• Vijayendra Dasari was awarded a Training Fellowship from the ACVD-Emory Vaccine Centre.

In total, more than 20 travel awards were received from organisations including the Australian Twin Registry, the Cancer Council Queensland and the Australian Society for Parasitology. These awards allow students to attend and present at conferences within Australia and overseas. PhD students Franziska Bieri, Yi Lu and Maggy Sikulu were also awarded prizes for their conference presentations.

australia fellowshipThe Australia Fellowships, awarded by the NHMRC, recognise outstanding health and medical researchers across all disciplines. The recipients have international status in their fields and are now conducting research programs of major impact and benefit to Australia.

Only 39 Australia Fellowships were ever awarded and two of QIMR researchers, Professors Emma Whitelaw and Geoff Hill are among them.

australian academy of Science fellowsElection to the Australian Academy of Science (AAS) Fellowship recognises a research career that has significantly advanced the world’s store of scientific knowledge. QIMR currently has five AAS Fellows:

• Professor Brian Kay;

• Professor David Kemp;

• Professor Nick Martin;

• Professor Peter Visscher; and

• Professor Emma Whitelaw.

Top recognition for QIMR researchers

Queensland government fellowshipsProfessor James McCarthy and Professor Michael Breakspear were awarded Health Research Fellowships from the Office of Health and Medical Research for their work in malaria and mental health respectively. Professor Geoff Hill also received a Senior Clinical Research Fellowship for his work in bone marrow transplantation for leukaemia.

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related commercial entitiesQIMR has assisted in the economic development of the State through its involvement in the establishment of start-up companies based in Queensland. QIMR has also been a key research provider to Queensland based company Ecobiotics Ltd since 2004.

Vactx

QIMR is a shareholder in VacTx Pty Ltd, a Melbourne based company established to develop vaccine technology arising out of the CRC for Vaccine Technology.

trust for cooperative research centre (crc) for Vaccine technology (crcVt trust i)

QIMR is the Trustee of the CRC for Vaccine Technology Trust, a trust managing shares in VacTx Ltd on behalf of the participants of the CRC.

trust for the cooperative research centre (crc) for Vaccine technology (crcVt trust ii)

QIMR is the Trustee of the CRC for Vaccine Technology (CRC –VT) Trust (CRCT Trust II), a trust responsible for managing patent families and licensing agreements on behalf of those participating in the CRC for Vaccine Technology, which was abolished in June 2006.

Vaccine Solutions

QIMR is a shareholder in Vaccines Solutions Pty Ltd, a company established to commercialise intellectual property resulting from the CRC for Vaccine Technology. The company has key licence agreements with Pfizer Inc.

Q-pharm

Q-Pharm Pty Limited is a specialised contract research organisation that undertakes a broad range of early phase (Phase I and Phase II) clinical trials for clients in the global pharmaceutical and biotechnology industries. QIMR holds a 24.5% share and Q-Pharm pays a licence fee per annum to QIMR to lease office, laboratory and clinical trial ward facilities in the Clive Berghofer Cancer Research Centre, and for information technology services and stores services. For details, see page 99.

QIMR has achieved significant health outcomes and secondary economic benefits through its connections with industry. These include the development of cancer therapeutics, diagnostic targets, cancer vaccines and infectious disease vaccines. Its reputation for excellence is further enhanced through its collaborative projects with companies and its involvement in projects of commercial significance.

QIMR undertakes industry sponsored collaborative research with a large number of local, national and international companies. Currently, QIMR has contracts with over 20 national and international biotechnology and pharmaceutical companies. In 2010-2011, 15 new projects were established with companies attracting approximately $2 million in external revenue. QIMR is a strong research partner of Queensland companies CBio and Ecobiotics.

Contract research carried out in QIMR has resulted in the discovery and development of cancer therapeutic agents and other commercial products.

Commercial consequence

and for information technology services and stores services. For details, see page 99.and for information technology services and stores services.


Business developmentThrough commercial grant proposals and the negotiation of commercial agreements with industry partners, QIMR is working to build and strengthen the Institute’s reputation.

The majority of agreements this financial year have been providing research services to Queensland-based

industries, and also include collaborative research with large international companies.

QIMR’s patent portfolio supports a strong presence in tropical and infectious diseases, with a significant proportion in vaccine technologies. For a full list of patents, see page 127.

Phase I clinical trials have commenced using the monoclonal antibody KB004 to determine if it might be efficacious in humans. It is the culmination of 25 years of research for QIMR researcher Professor Andrew Boyd, Head of the Leukaemia Foundation Laboratory.

KB004 has been shown to kill certain types of cancerous tumours in a laboratory using human samples. It is targeted towards EphA3 expressing haematologic malignancies, which are believed to account for about 50% of acute leukaemias as well as a number of other human cancers including a significant proportion of malignant melanomas, brain tumours and lung cancers.

KaloBios Pharmaceuticals, a San Francisco biotechnology company took the original mouse antibody and through a process known as Humaneering™ technology, developed an antibody that could be used in humans as it would be more likely to be tolerated by the human immune system.

The initiation of a Phase I clinical trial in patients with acute leukaemia by KaloBios is an important landmark and will hopefully lead to further testing and the ultimate use of this antibody as a treatment.

The development of this antibody as an anti-cancer therapeutic was the result of a collaboration between QIMR’s Professor Andrew Boyd, Professor Andrew Scott from the Ludwig Institute and Associate Professor Martin Lackmann from Monash University, who initiated and lead the translational aspects of this venture. It would not have been possible without ongoing financial support for Professor Boyd from the Leukaemia Foundation.

KB004 is a first-in-class engineered IgG1κ antibody targeting the EphA3 receptor tyrosine kinase. Developed using KaloBios’ proprietary antibody Humaneering™ technology, KB004 has variable regions that are very similar to human germ-line sequences, providing the potential for low immunogenicity in patients. In addition, KB004 is engineered to enhance antibody-dependent cytotoxic (ADCC) activity.

Life work culminates in testing of cancer therapy in humans

research agreements patent portfolio






License agreements

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Drug Target Patents

Diagnostic Patents

Delivery Platform PatentsPatent portfolio 2010-2011

Vaccine Patents


Drug Target Patents

Diagnostic Patents


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addressing society’s health needs

cancer

1 in 2 Australian’s will be affected by cancer before the age of 85. For that reason cancer research continues to be a major focus for QIMR. In 2010-2011, QIMR made a number of important cancer discoveries that can help the community in making informed decisions about their health and lifestyle, including:

• Showing that people with many moles, or with a family history of melanoma are significantly more like than others to develop a second melanoma. This result will help identify people who are at higher at risk and require more regular surveillance;

• Showing scientifically that the regular use of sunscreen prevents melanoma. The effectiveness of sunscreen to prevent melanomas has been a point of conjecture among researchers and clinicians for many years. This evidence supports the importance of regular sunscreen application, which provides valuable strength to the long running slip slop slap health campaigns;

• Finding evidence that long chain fatty acids found in oily fish such as salmon, anchovies and sardines, may be able to precent skin tumour formation, reinforcing the importance of oily fish in a well balanced diet;

• Finding that in combination smoking, obesity (BMI ≥30 kg/m2) and acid reflux together accounted for 76% of oesophageal adenocarcinoma cases. When considered separately, smoking, obesity and frequent reflux (≥weekly) accounted for 29%, 23% and 36% of these cancers respectively. This study suggests that these cancers may be largely prevented by maintaining healthy BMI, avoiding smoking and controlling symptomatic gastroesophageal reflux in the population;

• Discovering that high intakes of folates from food sources are associated with lower risks of oesophageal cancers;

• Demonstrating that regular walking for women undergoing chemotherapy for ovarian cancer is safe, feasible and acceptable to women;

• Finding that diets with a high glycaemic load may increase the risk of ovarian cancer, particularly among overweight/obese women, and a high intake of fibre may provide modest protection; and

• Discovering an increased risk of both pancreatic and colorectal cancer in the relatives of patients with serrated polyposis, which help identify people at higher risk and require regular checkups.

QIMR’s mission is better health through medical research. Gaining support from funding bodies, the government and the community, QIMR is committed to performing research which addresses the health needs of our society.

The Institute’s research provides valuable information to assist policy makers enhance the health of the wider community and help individuals make well informed decisions about their own health. QIMR researchers also rely on members of the community to support their research by sitting on advisory groups and volunteering to participate in a range of research projects.

QIMR ensures the public is informed about our research and is committed to inspiring the students of tomorrow through its education program.

Societal impacts

able to precent skin tumour formation, reinforcing the importance of oily fish in a well balanced diet;importance of oily fish in a well balanced diet;able to precent skin tumour formation, reinforcing the importance of oily fish in a well balanced diet;

require regular checkups.


infectious Diseases

Infectious disease is the cornerstone of QIMR, having been established in 1945 to combat tropical diseases affecting Queensland. Researchers at the Institute are world leaders in a range of infectious diseases that affect communities thoughout the world including malaria, HIV, schistosomiasis and scabies. Many of the diseases under study are simultaneously the cause of very significant morbidity and mortality, but are also often understudied by other research groups elsewhere in the world. The infectious agent may be parasitic (e.g. malaria), viral (e.g. HIV/AIDS), or bacterial (e.g. streptococcus A). In 2010–2011, QIMR carried out a number of studies to reduce the spread of infectious diseases through the community, including:

• Developing a new system for public health officials to monitor for outbreaks of Ross River virus disease and Barmah Forest virus disease. The VEDS (vector-borne disease early detection and surveillance) system is a joint venture between QIMR and Queensland Health to provide timely data about the prevalence of mosquito-borne diseases within Local Government Areas in Queensland;

• Conducting surveys on domestic mosquito breeding in and around Brisbane, using GPS and portable tablets to integrate this data into VEDS. Information collected will help advise local council and residents on strategies to remove potential breeding grounds for mosquitoes and reduce the overall incidence of mospquito-borne diseases;

• Commencing a field trial in Cairns to test how well Wolbachia can spread into mosquito populations in the wild and prevent the spread of Dengue Fever; and

• Contributing to the World Health Organization Malaria Rapid Diagnostic Tests Product Testing Program (Round 3) to provide invaluable guidance for governments and non-profit organisations that purchase these products.

mental Health/complex Disorders

Disorders such as cardiovascular disease, endometriosis, asthma and mental illness are complex to treat and are often poorly understood, despite affecting large numbers of people in Australia and throughout the world. Complex conditions can impact greatly on an individual’s lifestyle and make daily life difficult. QIMR has a dedicated Mental Health/Complex Disorders Program to investigate these disorders. In 2010–2011, the Program made several discoveries that may offer solutions to individuals to improve their behaviours, and in turn their health, including:

• Discovering that eating or drinking full fat dairy may reduce the risk of cardiovascular related death;

• Finding 30 new genes that control the age of sexual maturation in women and identified several genetic links between early puberty and body fat;

• Developing a Supportive Care Needs Survey for Indigenous People (SCNS-IP) with cancer. The SCNS-IP tool provides a standardised assessment of the supportive care needs of Indigenous adults with cancer in a culturally appropriate manner; and

• Identifying two genetic variants that increase the risk of developing endometriosis, giving hope to patients, by validating he condition which has often been dismissed by clinicians. Endometriosis is a painful, gynaecological disease that is estimated to affect six to ten per cent of all women in their reproductive years.

partnership with the communityMuch of QIMR’s research could not be completed without contribution from the community. QIMR has teamed up with individuals, patient groups and community groups to conduct a range of research projects including:

• QIMR researchers have embarked on the world’s largest skin cancer survey. 200,000 people will be invited to participate. The survey was developed in close consultation with Melanoma Patients Australia. Data collected will support the development of a scientifically based risk assessment tool to be used by all general practicians. This will enable doctors to accurately identify those at greater risk of developing skin cancers and melanomas and to work with the patient to implement risk minimising strategies;

• QIMR is heading the largest Australian study of asthma genetics. Over 5,000 people have participated, enabling researchers to search for genes that increase the risk of developing asthma;

• Researchers in the Clinical Medicine Laboratory are conducting a human clinical trial on healthy volunteers to develop a sensitive scientific protocol that will enable the testing of potential new antimalarial drugs in a controlled clinical setting;

• Depression is the leading cause of disability worldwide (WHO, 1990). In response to this growing health crisis, QIMR’s Mental Health Division, which officially opened on 11 February 2010, continues to be an area of much growth within the Institute. The aim is to work with the community to reduce the stigma of mental illness and improve treatment and access so it is on parity with physical illnesses. An area of focus is the development of a diagnostic tool for depression and other major psychiatric diseases. The techniques will also be applied to identifying depression or early dementia in our ageing population and will rely on volunteers from the healthy population as well as patients suffering from mental illness; and

• Over 6,000 identical and non-identical twins have volunteered to assist researchers from the Genetic Epidemiology and Molecular Epidemiology Laboratories disentangle the impact of genes versus environmental on the risk of developing a range of diseases. By studying twin data, QIMR researchers have found genes responsible for: schizophrenia, bipolar disorder, glaucoma, dyslexia, endometriosis, addiction, migraine, and melanoma.

supportive care needs of Indigenous adults with cancer in a culturally appropriate manner; andsupportive care needs of Indigenous adults with cancer in a culturally appropriate manner; and

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community engagementQIMR strongly values the support of the community and is committed to keeping the public informed about its research outcomes.

The External Relations Department’s Community Engagement Program aims to increase community awareness, support and involvement in QIMR’s research. During the past year 4,000 people from 116 different community groups toured QIMR or booked a speaking engagement. QIMR also kept the community informed through a series of research roadshows located at Kedron; Toowoomba; Gold Coast and Nambour.

QIMR’s public seminar program continues to provide opportunities for members of the public, community groups, and health specialists to hear from our researchers. This year, a Mental Health Forum was held on 26 October 2010 and a Women’s Health Forum on 16 March 2011.

As part of the National Science Week activities, QIMR participated in the annual Exhibition (Ekka) at the Brisbane Showgrounds from 5 – 14 August 2010. Children and adults participated in hands-on science activities including pipetting, diluting, running a DNA gel, as well as examining a range of cells and parasites under microscopes.

education programTo address the decline in the number of students completing science based degrees and to ensure a supply of quality researchers into the future, QIMR’s Education Program aims to inspire the scientists of tomorrow. Over 1,000 senior school students and their teachers from all around Australia have toured QIMR this year and heard first hand from researchers about science and potential career options. This included 600 students and 55 teachers attending the High School Lecture Series and more than 40 students placed in QIMR laboratories as part of the school work experience program.

Other outreach educational activities included a Science and DNA day at Albany Creek primary school; Professor Emma Whitelaw participating in the Scientist-in-Schools program; and QIMR joining Operation Archimedes to support Milpera State High School badly affected by the Queensland floods.

PhD student Franziska Bieri from the Molecular Parasitology Laboratory travelled to the remote Chinese province of Hunan to teach local children how to avoid contracting intestinal worms, such as whipworm, hookworm and roundworm. Infection with these worms in children leads to malnutrition, stunted growth and development.

The aim of the project was to improve personal hygiene habits and reduce reinfection. An entertaining cartoon DVD was developed to educate the schoolchildren about the importance of wearing shoes, washing their hands, boiling water for drinking and using lavatories instead of the local river.

Over 2,000 children between 9 and 11 years old participated in the study.

QIMR improving health in China


international lecturesResearchers from QIMR attended and presented at over 145 lectures throughout the world, reflecting its strong international reputation. Specific examples for 2010–2011 include:

• Professor Adèle Green was the Plenary Speaker for the British Society for Investigative Dermatology Annual Conference in Manchester;

• Associate Professor Grant Ramm was a session chair at the World Congress on Iron Metabolism in Vancouver;

• Professor David Whiteman presented at the 1st International Conference on UV and Skin Cancer Prevention in Copenhagen; and

• Professor Frank Gannon was invited to deliver the Redfern Lecture at the 50th Anniversary of the Department of Biochemistry at the University of Leicester.

For a full list of international lectures please see our invited lectures table on page 112.

international awardsQIMR researchers were also recognised internationally with a number of awards:

• Professor Emma Whitelaw received the International Union of Biochemists and Molecular Biologists Jubilee Medal for her contribution to the understanding of transcription and epigenetic inheritance;

• Professor Don Mc Manus received an honorary membership of the American Society of Tropical Medicine and Hygiene, in recognition of outstanding accomplishment by an individual not an American citizen who has made eminent contributions to some phase of tropical medicine and hygiene;

• Dr Sarah Medland received the Fulker Awards by the Behavior Genetics Association for the best paper published in Behavior Genetics in 2010; and

• QIMR students Karin Verweij and Miriam Mosing received Early Career Investigator Program Travel Awards from the World Congress on Psychiatric Genetics.

QIMR is an internationally recognised centre for medical research, attracting outstanding researchers, funding and collaborators from around the world. Its research community consists of researchers and students from all corners of the globe.

QIMR researchers are highly regarded on the world stage and are regularly invited to participate in international conferences, meetings, committees and lectures.

Making their mark on a world-wide scale, QIMR researchers have also won numerous international awards and contribute to various collaborations.

International reputation

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international conferences/meetingsIn 2010–2011, QIMR supported a number of international conferences and meetings including:

• 7th Indo-Australian Biotechnology Conference in Brisbane, October 2010;

• Boden Research Conference in Canberra, November– December 2010 covering Metals in biological systems: structure, catalysis and metabolism; and

• International Skin Cancer Research Workshop in Brisbane showcasing the ongoing research into skin cancer in Queensland and Arizona, March 2011.

international panels/committeesInternationally, QIMR researchers are recognised for their expertise and are sought after to hold positions on international boards, societies and publication editorial groups, including:

• Professor Frank Gannon Chair of the Selection Panel for the European Research and Innovation Area Board;

• Professor Greg Anderson was awarded President Elect of the Society for the International BioIron Society;

• Professor David Whiteman is a member of the Fellowships committee for the International Agency for Research on Cancer; and

• Professor Don McManus was invited to become an editorial board member on the international Veterinarni Medicina journal.

overseas travelTravel by researchers and corporate staff is critical to facilitate collaborations and ensure the Institute keeps pace with new technologies and techniques.

Attendance of these meetings often give rise to new international contacts that are reflected in the many consortia that QIMR is involved in (see table page 47), in addition to individual international collaborations.

For a full list of overseas travel refer to page 132.

In Hong Kong, nasopharyngeal carcinoma (NPC) is one of the major cancers of males. This cancer is associated with a virus known as Epstein-Barr virus (EBV). In NPC patients, tumour cells contain EBV proteins while normal cells do not.

Researchers at QIMR have used this point of differentiation to develop a new experimental treatment for NPC. Unlike many other cancers, the presence of the EBV virus gives the body’s immune system a definite target.

By enhancing the patient’s own immune cells to more effectively target the EBV infected cells, while leaving the non-tumour cells alone, the treatment is non-invasive and nontoxic.

QIMR researchers have used similar immunotherapy techniques to successfully treat heart and lung transplant patients who had developed EBV-associated lymphomas after transplantation.

The first stage of the funded trial is to determine if the treatment is safe.

NPC patients are recruited in Hong Kong where blood is taken. The blood is flown to QIMR where the white blood cells (lymphocytes) are grown and trained to selectively kill EBV infected cells. The cells are then returned to Hong Kong where they are infused into the patient.

The Princess Alexandra Hospital in Brisbane has joined the study, allowing NPC patients in Queensland to participate.

Nasopharyngeal carcinoma (NPC) trials


major international collaborationsCollaborations are important for sharing resource and expertise, facilitating joint research and publications and building networks and relationships, all of which are essential for scientific excellence.

QIMR has a diverse research program as demonstrated by our extensive range of international collaborations including the following:

Program Project Research Collaborator locations

Cancer Ovarian Cancer Association Consortium

Studying genetic and environmental risk factors to inform preventive efforts, screening, future drug development and treatment

Germany, Belgium, USA, Finland, Japan, Denmark, Netherlands, Canada, Poland, UK

Breast Cancer Association Consortium

Analysing genetic and epidemiological data from breast cancer studies from around the world

Ireland, France, Denmark, Spain, Finland Japan, Russia, Sweden, Belgium, Cyprus, Italy, Australia, Mexico, Malaysia, Norway, Nigeria, Finland, Canada, Netherlands, Singapore, Sweden, Korea, Germany, Poland, Thailand, Taiwan, USA, UK

International Melanoma Genetics Consortium

Identifying new melanoma risk genes and assessing genetic and environmental interactions

UK, France, Germany, Israel, Italy, Latvia, Netherlands, Poland, Scotland, Slovenia, Spain, Sweden, USA, Argentina, Brazil, Chile, Colombia, Mexico, Uruguay

kConfab Understanding the genetics of familial breast cancer

UK, New Zealand

Colon Cancer Family Registry Increasing our understanding of multiple factors affecting familial colorectal cancer

New Zealand, Canada and USA

Nasopharyngeal Cancer Developing novels treatments for nasopharyngeal cancer (cancer of the nose and throat)

Hong Kong

Transplant Research Understanding the causes of graft-versus-host disease

North Carolina, USA

Nanotechnology Developing novel nanoparticle-based iron supplements and metal-based nanoparticles in order to develop novel diagnostic and therapeutic agents

Beijing, China

Infectious Diseases Eliminate Dengue Project Developing a biological control to eliminate dengue fever

Vietnam and UK, USA

International Research Alliance for Schistosomiasis Elimination

Developing strategies for eliminating schistosomiasis from developing countries worldwide

US, Switzerland, Mexico, UK and China

Malaria Assessing the quality of commercially available rapid diagnostic tests and antimalarial drug development

UK, Switzerland and USA

Mental Health/Complex Disorders

International Schizophrenia Consortium

Identifying the genetic causes of schizophrenia

UK and USA

Psychiatric Genome Wide Association Studies Consortium

Analysing the genetic causes of ADHD, autism, bipolar disorder, major depressive disorder, and schizophrenia

USA and Sweden

Indigenous Health Comparative study: Patterns of care, comorbidities and quality of life of Indigenous and non-Indigenous people with lung, head and neck, breast or gynaecological cancers

New Zealand

Alcohol and Nicotine Dependency Generation of a large biobank of adult twin families to identify novel genes for nicotine and alcohol dependence

St Louis, USA

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ouR ReSeARCH

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Cancer Program

professor georgia chenevix-trench, coordinator

The Cancer Program consists of 23 laboratories located in QIMR’s Bancroft Centre and the Clive Berghofer Cancer Research Centre. Research carried out in the Cancer Program covers a variety of topics, including:

• Identification of the genetic, epigenetic and environmental risk factors that underlie an individual’s risk of cancer;

• Studying the molecular changes that occur in precursor lesions that can subsequently give rise to cancer and those that occur during the formation of a tumour and its subsequent metastasis; and

• Development and testing of novel therapies for cancer in the laboratory and in clinical trials.

The Program has a strong focus on skin cancers, including melanoma; hormone-related cancers, such as those of the breast, prostate, ovary and endometrium; leukaemia and lymphoma, including exploring the complications that can arise after stem cell transplantation, which is used for the treatment of leukaemia; brain tumours; and tumours of the gastrointestinal tract.

Members of the Cancer Program have productive local and national collaborations with clinical oncologists, pathologists and biobanks, and many are also leading, or are involved in, large international consortia that have made great advances into our understanding of the genes that predispose individuals to many types of cancer.

The highlights for the Cancer Research Program in the last year have included:

• Recruitment of 22,000 people to QSkin, which upon completion will be the world’s largest study of melanoma and skin cancer;

• Development of a unique mouse model that spontaneously develops melanoma;

• Finding that deregulation of the HER3 receptor and its downstream pathway is involved in brain metastases;

• Delineation of the interleukin-17 pathway in chronic graft-versus-host disease following bone marrow transplantation for treatment of leukaemia, and of interleukin-6 in acute graft-versus-host disease;

• Development of a new compound from the rain forest that has anti-cancer activity;

• Completion of the first stage of a clinical study in Hong Kong to test a killer T cell-based therapy in patients with advanced nasopharyngeal cancer; and

• Acceptance in clinical practise both nationally and internationally that it is important to remove proximal serrated polyps from the colon.


antigen presentation and immunoregulationLaboratory Head: Dr Kelli MacDonald

The Antigen Presentation and Immunoregulation Laboratory investigates how donor and host antigen presenting cells contribute to immune responses after haematopoietic stem cell transplantation. This laboratory conducts research on antigen presenting cell (APC) development, mechanisms of antigen presentation and APC induced T cell responses and their regulation.

Highlights:

• Used a novel CSF-1R blocking antibody (M279) to demonstrate that macrophages protect against the early stages of graft-versus-host disease (GVHD).

• Published a study that explains why stem cell transplant recipients of mobilised stem cell grafts develop more chronic GVHD than recipients of bone marrow grafts, and identified the IL-17 pathway and macrophages as therapeutic targets for the prevention and treatment of chronic GVHD.

• Identified SOCS3 as a molecule involved in dampening T cell activity during GVHD.

Bone marrow transplantationLaboratory Head: Professor Geoff Hill

The Bone Marrow Transplantation Laboratory works towards understanding the mechanisms by which transplant recipients eradicate leukaemia but also develop life-threatening complications, particularly graft-versus-host disease.

Highlights:

• Delineated the IL-17 pathway as controlling factor in chronic graft-versus-host disease, the major late complication of bone marrow transplantation.

• Identified IL-6 as a critical pathogenic molecule in acute graft-versus-host disease.

• Demonstrated that the SOCS3 molecule regulates immune responses and poor outcome after bone marrow transplantation.

• Demonstrated that natural killer cells limit the ability of the immune system to generate killer T cells to control infection.

cancer and population StudiesLaboratory Head: Professor Adèle Green

The Cancer and Population Studies Group aims to understand the causes of cancer and how to better prevent and manage cancer. The group investigates the roles of environmental and personal factors in the causation of cancer and its precursors, and in cancer prognosis. The group collaborates with clinicians, statisticians and behavioural scientists and also with laboratory scientists to better understand the underlying mechanisms of carcinogenesis. Particular focuses are cancers of the skin and of the pancreas.

Highlights:

• Provided the first evidence from a randomised controlled trial that regular use of sunscreen prevents melanoma.

• Conducted a 16-year longitudinal population-based study, and showed no association between tobacco smoking and cutaneous squamous cell carcinoma (SCC), suggesting that cutaneous SCC should be taken off the list of tobacco–related cancers.

• Found evidence that that long-chain fatty acids found in oily fish such as salmon, anchovies and sardines, may be able to modify and prevent skin tumour formation.

cancer control groupLaboratory Head: Professor David Whiteman

The Cancer Control Group performs research into a number of different cancers, with a view to gaining practical knowledge for preventing these diseases, or limiting their adverse impacts. The need for such research is clear, given that almost one in three deaths in Australia is due to cancer.

Highlights:

• Recruited more than 22,000 people in the world’s largest study of melanoma and skin cancer, QSkin.

• Showed that people with many moles, or with a family history of melanoma, are significantly more likely than others to develop a second melanoma.

• Showed that obesity, acid reflux and smoking together account for more than 75% of all cases of oesophageal adenocarcinomas in Australia.

• Found that high intakes of folates from food sources are associated with lower risks of oesophageal cancers.

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cancer geneticsLaboratory Head: Professor Georgia Chenevix-Trench

The Cancer Genetics Laboratory investigates why some people get cancer, and how these cancers, particularly those of the breast, ovary and stomach, develop from a normal cell. The laboratory also looks at why these cancers are often found together in the same families and share many similar characteristics.

Highlights:

• Identified many genetic variants that increase the risk of breast and/or ovarian cancer, in the general population and in women who are already at high risk because they inherit a mutation in the BRCA1 or BRCA2 genes.

• Discovered that genetic variants in the gene that encodes telomerase can also alter a woman’s risk of ovarian cancer.

• Found that deregulation of the HER3 receptor and its downstream pathway is involved in the colonisation of brain metastasis, which suggests that anti-HER inhibitors may provide effective therapies.

cancer council Queensland (ccQ) transgenicsLaboratory Head: Associate Professor Graham Kay

The CCQ Transgenics Laboratory studies the epigenetic mechanisms that modulate gene expression and the role of tumour suppressor genes in preventing cancer during normal development.

Highlights:

• Used genome-wide analysis of epigenetic modifications to identify autosomal genes whose expression is modulated by Smchd1.

• Developed a unique mouse model that spontaneously develops melanoma.

cancer immunotherapyLaboratory Head: Dr Chris Schmidt

The focus of the Cancer Immunotherapy Laboratory is on understanding how the immune system succeeds in its fight against malignancies which is central to the future development of cancer immunotherapies.

Highlights:

• Optimised a novel technology for examining antigen-specific immune responses.

• Finalised a bank of matched normal and cancer cell lines from melanoma patients. This resource is generally available to researchers through an Enabling Grant from the NHMRC to the Australasian Biospecimen Network.

• Developed lentivirus vectors encoding cancer antigens, and found they could stimulate both helper and killer T lymphocytes efficiently.

cancer program | continued


clinical immunohaemotologyLaboratory Head: Associate Professor Maher Gandhi

The major research area in the Clinical Immunohaemotology Laboratory is the immunobiology of lymphoma. Interests include biomarkers, immuno-evasion, microRNA expression and cellular immunotherapies for virus associated lymphomas.

The research aims to understand the basis of lymphoma to devise new treatments that are less toxic and more effective; to establish new biomarkers that will help determine the most effective treatment strategies and to monitor response and relapse and understand the development of lymphomas.

Highlights:

• Entered the second year of Phase I clinical trial of adoptive immunotherapy in EBV-positive lymphomas.

• Performed an in-depth profile of viral microRNAs in a range of primary samples from histologically diverse EBV-positive lymphomas.

• Completed the second year of a multi-centre Phase II lymphoma trial, in which the laboratory will perform a correlative study in collaboration with Griffith University.

• Established the genetic susceptibility to immune thrombocytopenic purpura.

• Characterised the clinical and immunobiological characteristics of a new and highly aggressive EBV-positive lymphoma.

• Characterised a subtype of monocyte that has profound immunosuppressive properties in aggressive lymphoma.

Dendritic cells and cancerLaboratory Head: Associate Professor Alejandro Lopez

The Dendritic Cells and Cancer Laboratory explores the function of dendritic cells in patients with breast cancer and investigates the role of breast cancer stem cells in the generation of tumours. Resulting findings will yield novel dendritic cell-based immunotherapies.

Highlights:

• Generated data supporting a mathematical model for the initiation of cancer.

• Identified two molecules that are highly expressed in breast cancer stem cells that could be targets for immunotherapy.

• Identified characteristics of the breast cancer cells cultured in vivo that resemble primary tumours.

• Characterised a dendritic cell-like line to be used in an animal model of cancer immunotherapy.

Drug Discovery groupLaboratory Head: Professor Peter Parsons

The Drug Discovery Group combines expertise in cancer biology with genomics and drug discovery. Cell communication networks in serious cancers reveal responses that provide opportunities for prevention and treatment.

Highlights:

• Developed a new compound from the rainforest with anti-cancer activity. Studies of the mechanism of action have so far revealed the primary target of the compound, and given important clues about the cell signalling pathways that might be relevant to its action.

• Identified key regulators of melanoma invasiveness (in conjunction with the Oncogenomics Laboratory).

• Profiled cutaneous squamous cell carcinoma of the head and neck tumours with perineural invasion.

• Identified other plants from the rainforest that possess a range of potentially useful bioactivities including anti-inflammatory properties.

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familial cancer Laboratory Head: Dr Joanne Young

The Familial Cancer Laboratory examines the genetic changes that make some families more susceptible to colorectal and other cancers. This work is augmented by tumour pathology studies in families, and epidemiology studies in a multi-ethnic population.

Highlights:

• Discovered an increased risk of both pancreatic and colorectal cancer in the relatives of patients with serrated polyposis.

• Demonstrated that cryptic mutations in non-coding areas of genes can cause Lynch syndrome.

• Confirmed that Lynch syndrome can arise when neither parent is affected, but this is very rare.

• Described a model for serrated polyposis involving hypermaturity of the normal bowel wall producing a variety of polyp types.

• Found further evidence that genetic background can influence the expression of polyposis through studies of PTEN germline mutation.

gynaecological cancers groupLaboratory Head: Associate Professor Penny Webb

The Gynaecological Cancers Group investigates all aspects of gynaecological cancer from aetiology to diagnosis, patterns of care, quality of life and survival. A particular focus is on the role of environmental (non-genetic) factors and the interaction between genetic and environmental factors in the causation and prognosis of gynaecological cancer.

Highlights:

• Showed that once a woman with ovarian cancer experiences symptoms, shortening the time taken to diagnose her cancer is unlikely to lead to better survival.

• Found that approximately half of caregivers of women with ovarian cancer do not meet Australian guidelines for diet and physical activity and more than half report negative behaviour changes after becoming a caregiver.

• Showed that a walking intervention for women undergoing chemotherapy for ovarian cancer is safe, feasible and acceptable to women.

• Found that diets with a high glycaemic load may increase the risk of ovarian cancer, particularly among overweight/obese women, and a high intake of fibre may provide modest protection.

• Contributed to international studies that identified new genes for ovarian cancer.

• Found that women with polycystic ovarian syndrome are at increased risk of endometrial cancer.

Leukaemia foundation of Queensland LaboratoryLaboratory Head: Professor Andrew Boyd

The Leukaemia Foundation of Queensland Laboratory is exploring the biology of leukaemia and other cancers through studies of leukaemia-associated proteins. A major project is to understand the function of Eph and ephrin membrane proteins in cancer. Members of these protein families are highly expressed in many human cancers where, by actively promoting de-adhesion of cells, they contribute to tumour spread and invasion. The laboratory explores how these proteins function in a number of cancers through work in animal models and through in vitro studies.

Highlights:

• Started a clinical trial of anti-EphA3 antibody against leukaemias.

• Identified genes that may prove to be key therapy targets in glioma.


in animal models and through studies.


molecular cancer epidemiologyLaboratory Head: Associate Professor Amanda Spurdle

The Molecular Cancer Epidemiology Laboratory studies breast and ovarian cancer, endometrial cancer, colon cancer and prostate cancer, with a focus on identifying molecular signatures of normal and tumour tissue that can point to the genetic and environmental causes of these cancers. The laboratory covers a range of projects with the themes of cancer epidemiology and molecular pathology.

Highlights:

• Identified a genetic link between prostate and endometrial cancer.

• Confirmed that a prostate cancer locus identified in Japanese patients is also associated with disease in Caucasian individuals.

• Developed a qualitative scheme and a quantitative statistical model to interpret the significance of variants in mismatch repair genes, which predispose to familial endometrial and colorectal cancer.

• Continued work to assess the role of splicing aberrations as the underlying mechanism for mutation of breast and ovarian cancer predisposition genes BRCA1 and BRCA2, by leading a quality control project within the ENIGMA consortium Splicing Working Group.

oncogenomicsLaboratory Head: Professor Nick Hayward

The Oncogenomics Laboratory identifies novel cancer genes and studies the way in which defects in these genes are associated with cancer predisposition or development. In particular, the laboratory focuses on melanoma, oesophageal cancer, and endocrine tumours.

The laboratory is interested in investigating the process of cancer development at the level of individual cancer predisposition genes, and by looking at the whole genome scale. This work will lead to a better understanding of the genetic events that cause cancer and hopefully better ways of diagnosing or treating cancers in the future.

Highlights:

• Completed a genome-wide association study for melanoma and identified two new genes (PARP1 and SETDB1) that confer risk of melanoma in the general population.

• Carried out sequencing of selected cases from large melanoma-prone families and identified a variant in the MITF gene that is associated will melanoma susceptibility in some families, as well as the population at large.

• Shown that gene expression changes associated with the ability to combat the adverse effects of acid reflux may influence oesophageal cancer risk.

• Proven that individuals with Barrett’s oesophagus, a pre-cancerous tissue associated with oesophageal adenocarcinoma, often have chromosomal changes similar to those seen in oesophageal cancer.

• Found that expression of GATA4, a general transcription factor, is dysregulated in pancreatic tumours and may contribute to the development of multiple endocrine neoplasia.

radiation Biology and oncologyLaboratory Head: Professor Martin Lavin

The focus of the Radiation Biology and Oncology Laboratory is DNA damage response and its role in maintaining the integrity of DNA to minimise the risk of cancer and neurodegeneration.

Highlights:

• Revealed a new mechanism for activation of the protein defective in ataxia-telangiectasia (A-T) by oxidative stress.

• Identified additional sites of autophosphorylation for ATM activation.

• Used ATM mouse models to investigate DNA damage signalling and DNA repair.

• Developed a new mouse model for the autosomal recessive ataxia with oculomotor apraxia type 2(AOA2).

• Contributed to the establishment of a clinic for A-T patients on the Herston campus at UQCCR.

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rBWH foundation conjoint gastroenterologyLaboratory Head: Professor Barbara Leggett

The RBWH Foundation Conjoint Gastroenterology Laboratory identifies genetic changes which define distinct subtypes of colon cancers and premalignant polyps with the aim of predicting the clinical behaviour of these tumours. In this laboratory, scientists collaborate with gastroenterologists, pathologists, surgeons and oncologists on research that is only possible due to the large tissue bank comprised of samples kindly donated by patients.

Highlights:

• Influenced a major change in clinical practice with the acceptance nationally and internationally that it is important to remove proximal serrated polyps.

• Completed expression and methylation arrays on representative series of serrated polyps and cancers.

• Developed a mouse model of mutant BRAF expression in the adult intestine that leads to hyperplasia, which likely equates to early serrated polyp development.

• Found that villous change in polyps is associated with increased malignant potential even if it makes up less than 25% of the polyp.

• Demonstrated that the bacteria in the bowel are different in the proximal bowel of female subjects where serrated polyps are most likely to occur.

Skin carcinogenesisLaboratory Head: Dr Graeme Walker

The Skin Carcinogenesis Laboratory studies the mechanisms by which sun exposure modulates melanoma development.

Highlights:

• Found that melanoma localisation in the skin is controlled by stem cell factor released by other skin cells.

• Discovered that the Cdk4 gene drives the development of naevi (moles).

• Revealed that p53 gene loss in melanocytes resulted in the complete bypass of the precursor stage of melanoma progression.

• Completed studying 40 animal model strains, and found one carrying genes that greatly exacerbate melanoma development, and another with genes that dramatically slow it.

• Found that stem cells only divide in response to ultraviolet light in the presence of surrounding normal melanocytes.

• Constructing a model for the regulation of the activation of follicular melanocyte precursors, leading to better understanding of vitiligo, a condition characterised by white areas of skin due to a complete loss of melanocytes.

Signal transductionLaboratory Head: Professor Kum Kum Khanna

The Signal Transduction Laboratory researches signal transduction pathways involved in the detection, signalling or repair of DNA damage and seeks other genes in these pathways, which might have similar involvement in cancer susceptibility by preventing the generation of mutations in DNA.

Highlights:

• Discovered that the loss of a new DNA damage repair gene SSB1 is linked with susceptibility to lymphoma.

• Identified a new regulator of cell division (FBX031) that is lost in breast cancer.

• Developed a novel combination treatment to prevent recurrence and relapse of breast cancer.

• Identified a specific target necessary to improve treatment outcomes for patients with triple negative breast cancers.



professor James mccarthy, coordinator

The 19 laboratories that contribute to QIMR’s Infectious Diseases Program study how a range of important pathogenic organisms cause illness, search for better ways to diagnose and treat them, as well as developing vaccines to prevent infections. A major emphasis of work is on infections that disproportionately affect people living in the developing world and the tropics.

Pathogens studied include viruses such as HIV, cytomegalovirus, Epstein Barr virus and mosquito-borne viruses; bacteria such as streptococci; and parasites such as malaria, intestinal protozoa, worms and scabies. One laboratory in the program focuses on the application of proteomic technology to biomedical science.

QIMR’s ability to analyse large quantities of data has been enhanced with the establishment of the Bioinformatics Laboratory. This facilitates researchers’ ability to utilise advances in computational science and information technologies to understand biological systems and ultimately provide valuable insights into the causes of diseases.

A focus continues to be strong collaborations with clinicians, researchers from within QIMR and other institutes, as well as working with pharmaceutical companies to develop patented therapeutic technologies that improve the health of many.

QIMR is a founding member of the Queensland Tropical Health Alliance (QTHA), which is designed to enhance collaborations and networking in tropical health issues. QIMR’s Professor Brian Kay is currently Deputy Director.

Highlights for the Infectious Diseases Program in the last year have included:

• Development of molecular methods for rapid and accurate identification of the three human pathogenic streptococci species;

• Demonstration that the current diagnostic methods for assessing intravascular catheter related infection are inadequate for the care of critically ill patients;

• Successful establishment of the Bioinformatics Laboratory;

• Discovery of new regions of Epstein-Barr virus that are targeted by the immune response;

• Identification of a series of aminopeptidase inhibitors with potential as new antimalarial drugs, which are currently in the medicinal chemistry phase of development;

• The world’s first high throughput screening against malaria parasite gametocytes to identify compounds that are potential antimalarial therapies;

• The first gene atlas of multiple schistosome tissues. This dataset is a major resource to the research community in enhancing functional knowledge of key parasite proteins, particularly those used by the helminths in their feeding biology;

• Substantial data supporting a causal link between the biology of scabies and associated streptococcal infections; and

• Establishment of a system to test antimalarial drugs in human volunteers experimentally infected with malaria parasites.

Infectious Diseases Program

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Bacterial pathogenesis Laboratory Head: Professor Kadaba Sriprakash

The Bacterial Pathogenesis Laboratory undertakes research into Streptococcus and Staphylococcus and other medically important bacteria that cause a wide range of potentially fatal diseases in humans.

Highlights:

• Optimised and improved one of the current group A streptococcus (GAS) vaccine candidate molecules so that it remains immunogenic.

• Developed molecular methods for rapid and accurate identification of the three human pathogenic streptococci species.

• Demonstrated that the current diagnostic methods for assessing intravascular catheter related infection are inadequate for the care of critically ill patients.

• Established a multi-locus sequence typing scheme for group G streptococcus (GGS) with collaborators in Portugal and the USA.

• Collaborated on a project that will sequence 108 GGS genomes at the Wellcome Trust Sanger Centre, Cambridge, UK.

Bioinformatics Laboratory Head: Dr Lutz Krause

The Bioinformatics Laboratory develops and applies computational science and information technologies to biological systems. It specialises in data-mining, machine learning, phylogenetics, computational ecology, efficient algorithms for next-generation sequencing, epigenetics, biomarker-discovery, whole-genome-association studies, and genetics of complex disorders.

Highlights:

• Developed a computing infrastructure for mining, visualising and interpreting complex molecular biological datasets, which has already been applied in various medical research projects.

• Found that epigenetics – modifications of DNA that regulate the activity of genes – could play a role in mental disorders. The research findings could lead to the development of novel biomarkers or treatments.

• Demonstrated that used blood catheters are colonised by various different bacteria. These findings are important for preventing and maintaining blood infections, particular in intensive care units.

cellular immunologyLaboratory Head: Associate Professor Scott Burrows

The Cellular Immunology Laboratory researches Epstein-Barr virus (EBV) as a way to observe the human immune system. The main focus is the cytotoxic T lymphocyte and factors controlling its primary function in recognising and killing virus-infected cells, which affects vaccine development.

By investigating the interaction of the immune system with EBV (a virus that remains in the body for life) it provides insights into how to combat glandular fever and EBV-related cancers such as nasopharyngeal carcinoma and Hodgkin’s lymphoma.

Highlights:

• Discovered new regions of EBV that are targeted by the immune response.

• Discovered that inherited deletions in the genes that encode T cell receptors influence the immune response to viral infection.

infectiouS DiSeaSeS program | continued


clinical tropical medicineLaboratory Head: Professor James McCarthy

The Clinical Tropical Medicine Laboratory undertakes translational research in tropical infectious diseases. A particular focus is the identification and testing of new drugs, study of drug resistance, and the development of novel diagnostic techniques.

Highlights:

• Discovered that the main ingredient of clove oil is as effective against scabies mites as existing therapies.

• Developed and tested a system for experimental malaria infection of human volunteers to test the activity of antimalarial drugs in collaboration with the Malaria Biology Laboratory.

• Used its recently developed porcine scabies model to:

- demonstrate that Th17 associated cytokines contribute to the severe immune pathology of crusted scabies, a life-threatening and poorly understood complication of scabies;

- profile the humoral immune response to Sarcoptes scabiei over the course of infection, thereby informing the development of serodiagnostic tests for scabies; and

- completed an exploratory clinical trial to define activity of a licensed veterinary tick treatment against S. scabiei infection.

• Completed a study investigating whether hookworm infection improves gluten tolerance in celiac disease and showed no obvious benefit for symptoms.

• Developed a motility-based assay to test the efficacy of antihelmintic drugs.

• Began a project to investigate the benefits of community-based de-worming programs in a remote northern Australian Indigenous community.

epstein-Barr Virus Biology Laboratory Head: Professor Denis Moss

The Epstein-Barr Virus Biology Laboratory is committed to understanding the biology and immunology of two clinically important human pathogens, namely Epstein-Barr virus (EBV) and vaccinia virus. The EBV Laboratory findings are captured for use in human clinical trials.

EBV causes glandular fever and is associated with a number of cancers, including lymphomas in transplant patients and a relatively common form of cancer in the back of the nose called nasopharyngeal carcinoma. The EBV Biology Laboratory has a broad interest in all aspects of the biology of the virus and is closely linked with other EBV laboratories within the Immunology Department.

Highlights:

• Completed an immunotherapy trial in collaboration with the Head and Neck Department, Princess Alexandra Hospital, Brisbane.

• Screened 1,000 extracts from EcoBiotics’ plant extract library and identified 240 extracts which may have adjuvant or immunosuppresive activity and will be further studied.

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HiV molecular VirologyLaboratory Head: Dr David Harrich

The HIV Molecular Virology Laboratory analyses human immunodeficiency virus (HIV) replication. This includes the process by which HIV is able to convert its genetic material composed of RNA into a form compatible with human DNA. The laboratory’s focus is the discovery of key viral or cellular molecules required for HIV to grow, and then to target their action so that HIV growth can be effectively blocked.

Highlights:

• Revealed a non-canonical role for translation factors in early steps of HIV replication.

• Disrupted HIV-1 Rev trafficking by mutating a HIV Tat protein.

• Defined critical parameters of Tat and PRMT6 interaction.

• Created a potent HIV-1 inhibitor called Nullbasic that can target the virus replication complex, acting even before a cell becomes infected. Further research will define precisely how the inhibitor functions with a goal to advance this as a new HIV therapy.

• Found that human cells treated in the laboratory with gene therapy vectors are strongly resistant to HIV-1 infection.

immunity and VaccinologyLaboratory Head: Associate Professor Colleen Olive

The Immunity and Vaccinology Laboratory investigates the immunological mechanisms of pathogen recognition and intracellular signalling pathways that culminate in host immunity, with the objective of developing new vaccines for infectious diseases.

Highlights:

• Designed a multifunctional vaccine delivery platform that can be tailored to generate specific types of immune responses against various pathogens through the combination of different Toll-like receptor (TLR) agonists, peptides, and targeting moieties.

• Designed a novel group A streptococcal vaccine based on polyfunctional liposomes that is designed to optimally activate key immune cells called dendritic cells (DCs) and provide protection against mucosal bacterial colonisation.

• Demonstrated functionality of the vaccine in terms of ability to bind to DCs, stimulate TLRs and induce the production of cytokines required for an effective immune response.

• Identified TLR signalling pathways in DCs that may be altered for modulation of immune responses.

immunology and infectionLaboratory Head: Dr Christian Engwerda

The Immunology and Infection Laboratory studies the host immune response during malaria and leishmaniasis, and aims to distinguish anti-parasitic host immune responses that control disease from those that cause disease.

Highlights:

• Identified the lymphotoxin beta receptor found on immune cells as an important therapeutic target to treat visceral leishmaniasis.

• Discovered that type I interferons potently suppress anti-parasitic T cell responses directed against blood stage malaria parasites.

• Showed an interdependent relationship between parasite burden in tissues and the activation status of immune cells in these sites during malaria. This has implications for understanding how disease develops and can be treated.



immunovirologyLaboratory Head: Professor Andreas Suhrbier

The Immunovirology Laboratory is developing and exploiting knowledge about interactions between viruses and the immune system to develop new anti-cancer, antiviral and anti-inflammation strategies.

The search for the role of SerpinB2 in inflammatory disease has been a major theme of the laboratory for several years.

Work on mosquito-borne viruses has been a long standing research field for the laboratory with work on Ross River fever and chikungunya virus, illustrating the importance of immune cells, called macrophages, in the development of arthritis. The research aims to understand how the disease is caused and develop new strategies for treatment.

Highlights:

• Tested chikungunya virus vaccines.

• Investigated the activity of ingenol mebutate, a new topical treatment for actinic keratoses and non-melanoma skin cancer.

• Investigating further the mechanism of action of chaperonin 10, a new drug being trialled in rheumatoid arthritis and psoriasis patients.

malaria Biology Laboratory Head: Associate Professor Don Gardiner

The Malaria Biology Laboratory researches the molecular and cellular processes involved in critical phases of the malaria parasite life cycle in order to identify novel drug targets and to translate fundamental biological research into new interventions for the control of malaria. The laboratory has a fully integrated research program that uses established research methods in conjunction with recent advances in malaria transgenics, molecular modelling and in vivo and in vitro testing.

Highlights:

• Completed two US National Institutes of Health (NIH) funded high throughput screens and identified a series of novel aminopeptidase inhibitors with the potential to undergo development as antimalarial drugs.

• Completed a human malaria infection study for testing new antimalarial drugs in collaboration with the Clinical Tropical Medicine Laboratory.

• Identified an aminopeptidase inhibitor with potent in vivo antimalarial activity.

• Developed a high throughput screening assay for drugs that inhibit the growth and development of malaria parasite gametocytes.

• Performing the first high throughput screen against Plasmodium falciparum gametocytes to identify compounds with anti-gametocyte activity.

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molecular parasitologyLaboratory Head: Professor Don McManus

The Molecular Parasitology Laboratory researches the biology and epidemiology of parasitic worms of humans and works on developing new interventions and diagnostic procedures that will lead to their elimination.

The laboratory researches parasitic worms of humans, particularly schistosome blood flukes, which are responsible for the potentially debilitating disease schistosomiasis (Bilharzia), and dog tapeworms (Echinococcus), which are the cause of hydatid disease.

Highlights:

• Determined that the dominant antigen in hydatid cyst fluid, Antigen B (EgAgB), is encoded by a gene family comprising 10 unique genes and that these are expressed at different life cycle stages of Echinococcus granulosus.

• Showed that inconsistent protective efficacy and marked polymorphism limits the value of Schistosoma japonicum tetraspanin-2 as a vaccine target.

• Determined aspartate aminotransferase, hyaluronic acid and matrix metalloproteinase were reliable and sensitive markers for the diagnosis of fibrosis and cirrhosis in advanced schistosomiasis patients.

• Identified cellular and transcriptional features that correlate to the outcome of hepatic pathology using contrasting mouse models.

malaria Drug resistance and chemotherapy Laboratory Head: Dr Michelle Gatton

This Malaria Drug Resistance and Chemotherapy Laboratory studies malaria and selected other mosquito-borne diseases using theoretical and laboratory techniques for the purpose of improving surveillance, diagnosis, treatment and control of those diseases.

Highlights:

• Demonstrated a variety of phenotypic changes in vitro that occur when Plasmodium falciparum parasites become resistant to artemisinin.

• Established that the amount of HRP2 antigen produced by a parasite varies between different parasite lines and this affects the sensitivity of malaria rapid diagnostic tests.

• Identified that pre-existing antibodies against HRP2 in patient blood can block the detection of malaria parasites by some malaria rapid diagnostic tests.

• Contributed to the World Health Organization Malaria Rapid Diagnostic Tests Product Testing Program (Round 3) to provide invaluable guidance for governments and non-profit organisations that purchase these products.

• Developed statistical methodology to increase the utility of data and results produced by the Schizont Maturation Test when used on Plasmodium vivax parasites.

• Estimated the duration of each asexual life stage in Plasmodium vivax, a parasite that can not readily be cultured in the laboratory.

• Developed an interactive web-interface for scientists to estimate the age of a mosquito population.

• Produced the Vector-borne disease early detection and surveillance (VEDS) system. The VEDS system currently monitors Ross River virus and Barmah Forest virus in real-time in Queensland.



molecular VaccinologyLaboratory Head: Professor Denise Doolan

Research in the Molecular Vaccinology Laboratory investigates the molecular basis of immunity to disease, with a focus on malaria and model systems that can inform the basic immunology, mechanisms and antigenic targets of immunity, and evaluation of candidate vaccines.

This laboratory works with humans using samples from areas such as Africa and Papua New Guinea.

Highlights:

• Established that T cell responses and antibody responses to the Plasmodium parasite are broadly distributed throughout the genome, suggesting that vaccine efforts restricted to only one or a few parasite proteins are not likely to be highly effective.

• Established that antigens that are highly reactive for T cells are not highly reactive for antibody responses. Different approaches are required to identify the most effective targets of T cell responses and antibody responses.

• Identified a putative signature of sterile protective immunity against malaria comprising 19 proteins, 17 of which are novel. These proteins are excellent candidates for the development of a malaria vaccine or a diagnostic tool.

• Identified novel proteins targeted by T cell responses of individuals with immunity to malaria that are much better targets than current vaccine candidates. These proteins are excellent candidates for a vaccine designed to prevent both the clinical symptoms and transmission of malaria.

• Developed an assay for the rapid and reliable analysis of multiple parameters of parasite infection and host response from very small quantities of blood. This assay allows the progression of infection and immune responses to be closely monitored in the laboratory or field.

mosquito control Laboratory Head: Professor Brian Kay

Research in the Mosquito Control Laboratory focuses on the biology and control of mosquito-borne viruses such as dengue, Ross River virus and Barmah Forest virus. This laboratory is designated by the World Health Organization (WHO) as an official global Collaborating Centre for Environmental Management for Vector Control.

The laboratory specialises in designing new mosquito surveillance and control strategies and has strong collaborative linkages with dengue prevention research groups in Vietnam and Australia and work directly with local government in Queensland regarding mosquito control and all mosquito-transmitted arboviruses.

The Mosquito Control Laboratory has the largest quarantine approved insectary in Australia.

Highlights:

• Evaluated the safety of infecting mosquito with strains of the endosymbiont bacteria, Wolbachia.

• Commenced a field trial in Cairns to now test how well Wolbachia can spread into mosquito populations in the wild.

• In collaboration with the Malaria Drug Resistance and Chemotherapy Laboratory, created a decision support tool called VEDS (vector-borne diseases early detection system) to include Barmah Forest, and Ross River virus data and supporting entomological surveillance data. This system is designed to take raw incidence data and transform it into a risk analysis framework to prompt early response.

• Conducted surveys on domestic mosquito breeding in and around Brisbane, using GPS and portable tablets to integrate this data into VEDS.

• Developed a proteomic assay to determine the age of Aedes aegypti mosquitoes. These assays will be essential to evaluating mosquito control strategies that are designed to modify or shorten life expectancy.

• Identified proteins in Anopheles mosquitoes that will be used to evaluate their age.

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parasite cell Biology Laboratory Head: Associate Professor Malcolm Jones

The Parasite Cell Biology Laboratory researches three specific parasites: schistosomes (human blood flukes), the hydatid tapeworm Echinococcus granulosus and the malaria parasite Plasmodium. A range of molecular, protein and advanced microstructural characterisation technologies are employed to study the cell biology of these parasites, particularly in relation to their host interactions – an aspect which can be exploited in control strategies.

Highlights:

• Completed a gene atlas of human schistosomes, providing essential functional data on many schistosome molecules for future vaccine development.

• Described the native structure of two helminth SAPLIPs+C11 molecules proposed to have major roles in red blood cell lysis.

• Demonstrated efficacy of novel peptide as antihelminthics for treatment of schistosomiasis.

protein Discovery centre Laboratory Head: Professor Jeff Gorman

The Protein Discovery Centre is a state-of-the-art facility in the mass spectrometry and proteomics field. It is one of the most advanced and best equipped of its kind in Australia. The centre collaborates broadly on both national and international projects.

The centre aims to discover the identities of proteins involved in and/or affected by physiological and disease processes and the ways in which these proteins function and interact and to develop techniques to observe stimulated cells and the reaction within cell proteins.

Highlights:

• Uncovered a mechanism by which respiratory syncytial virus dampens the oxidative stress response of infected cells.

• Discovered that proteins of viruses from the same family as respiratory syncytial virus are modified extensively by phosphorylation and by ubiquitination.

• Uncovered evidence for association between proteins of the infected cell and viruses from the same family as respiratory syncytial virus that modulate budding of new viruses from the infected cell.

• Identified a cohort of novel cartilage proteins and biological processes associated with cartilage development.

• Characterised protein expression differences that appear to correlate with a breast cancer stem cell phenotype.

• Invested in two new state-of-the-art LTQ-Velos-Orbitrap mass spectrometers to complement other high performance MALDI-TOF/TOF mass spectrometers.

Scabies Laboratory Head: Dr Katja Fischer

Work in the Scabies Laboratory concentrates on the control of diseases caused by the scabies mites, Sarcoptes scabiei that burrow under the skin to cause the condition commonly known as scabies.

Highlights:

• Biochemically characterised two scabies mite Serpins and provided a detailed analysis of their anti-complement activities.

• Identified and characterised a novel scabies mite’s peritrophin.

• Provided substantial data supporting a causal link between the biology of scabies and associated streptococcal infections.

• Constructed a library of expressed Sarcoptes scabiei sequences from mites obtained from skin shed into the bedding of patients with the severe form of the disease, crusted scabies. A multi-gene family was identified during this sequencing in which the amino acids necessary for catalysis are mutated and therefore cannot function as active proteases.

• Established material and preliminary data to commence a S. scabiei genome project.


Established material and preliminary data to commence S. scabiei

Established material and preliminary data to commence


tropical parasitology Laboratory Head: Dr Kathy Andrews

The Tropical Parasitology Laboratory is using different approaches to investigate new antimalarial compounds and potential new drug targets. In a piggy back approach, anti-cancer and anti-HIV drugs (and related compounds) are being investigated for their ability to kill malaria parasites. To complement this work, the laboratory is using molecular, biochemical and synthetic chemistry approaches to identify and validate the targets of antimalarial compounds and to better understand essential processes, such as transcriptional regulation, in malaria parasites.

Highlights:

• Conducted genome wide microarray analysis that provided new insights into how histone deacetylase inhibitors (a promising new antimalarial drug class) kill malaria parasites.

• Identified new antimalarial compounds from plants and fungi in collaboration with Griffith University researchers.

tumour immunologyLaboratory Head: Professor Rajiv Khanna

The main goal of the Tumour Immunology Laboratory is to obtain a deeper understanding of the mechanisms by which an immune response to tumours may be generated, augmented and applied to the inhibition of tumour growth.

The members of this laboratory share the expectation that such insight will be applicable to the treatment and prevention of cancer.

Highlights:

• Developed a killer T cell therapy for EBV-associated nasopharyngeal carcinoma.

• Completed the preclinical testing of a prophylactic vaccine for cytomegalovirus. A Phase I clinical trial is planned for this vaccine, which aims to prevent clinical complications in transplant patients and newborn babies.

• Continued trialling a novel immunotherapy for brain cancer.

• Started a clinical trial of a novel immune-based diagnostic tool for cytomegalovirus.

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associate professor michael Breakspear, coordinator

Recent structural change at QIMR brought teams from a variety of disciplines together into the new Mental Health/Complex Disorders Program. The new structure recognises that QIMR must continue on the road to building a major research capacity in mental health whilst fostering outstanding biomedical research of major clinical relevance. Whilst the disease focus is broad and multi-system, the program is united by a number of common conceptual and methodological themes. The diseases studied within the program, ranging from schizophrenia and depression to haemochromatosis and migraine, all arise from an interaction of genetic and multi-factorial environmental influences.

The last twelve months have been a watershed year for Mental Health with a series of high profile national developments, new funding opportunities and, most importantly, growing awareness in the community. QIMR scientists continue to make important breakthroughs in mental health research from genetics and epidemiology to brain imaging and computational modelling. Research capabilities, technology opportunities and public awareness into mental health continue to grow - creating a unique opportunity for research at QIMR to improve recovery and outcome for those in the community with mental health disorders.

Important discoveries have also occurred in the Complex Disorders of other key systems that we study, including diseases of iron metabolism, those involving fibrosis of the liver, those arising from abnormal membrane transport and a constellation of disorders with a strong genetic underpinning. Advances in basic clinical science include the development of new laboratory techniques to study foetal alcohol syndrome, insights into the role of inflammation in haemochromatosis and the nature of genetic factors in endometriosis and inflammatory bowel disease. Insights into the genetic determinants of a range of healthy variants of human intelligence, emotion and appearance have also been achieved. Here it again becomes

clear that the two arms of the program (Mental Health/Complex Disorders) overlap.

Technology plays a crucial role in the study of these disorders. QIMR is home to a growing number of imaging technologies that enable unprecedented insight into the biology of cells, animals and humans. Cutting edge animal imaging facilities were recently installed and plans for a major new human imaging facility on the Herston campus are well advanced. The growth of sequencing technologies that underpin genetic research also continue. The enormous volume of biological data generated by these technologies demands a new approach to data analysis. Scientists across the program are actively engaged in QIMR’s expansion in Information Technologies and Bioinformatics.

Highlights for the Mental Health/Complex Disorders Program in the last year include:

• Development of a new brain stress test to predict outcome in older Australians at risk of dementia, a major national public health priority.

• Advancing our understanding of healthy brain activity, including the nature of brain rhythms and the disturbance of these rhythms in schizophrenia.

• Through participation in large international consortia, QIMR researchers also made important discoveries in the genetic basis of major mental illnesses, including depression, schizophrenia and migraine.

• Providing new insights into the genetic contributions to a myriad of healthy human behaviours including visual perception and personality style.

• The use of a liver biopsy to provide vital clinical information to predict the future development liver disease in children with cystic fibrosis,

• Improving our understanding of the role of malabsorption of iron in anaemia.

• Confirming a genetic contribution to endometriosis risk, with stronger genetic effects for more severe disease.


range of healthy variants of human intelligence, emotion and appearance have also been achieved. Here it again becomes appearance have also been achieved. Here it again becomes range of healthy variants of human intelligence, emotion and appearance have also been achieved. Here it again becomes appearance have also been achieved. Here it again becomes

Confirming a genetic contribution to endometriosis risk, with stronger genetic effects for more severe disease.with stronger genetic effects for more severe disease.Confirming a genetic contribution to endometriosis risk, with stronger genetic effects for more severe disease.


epigeneticsLaboratory Head: Professor Emma Whitelaw

The Epigenetics Laboratory aims to understand the basic mechanisms of disease at a molecular level. The laboratory focuses on chemical changes to DNA and chromatin, the proteins that package DNA.

Highlights:

• Developed a mouse model of fetal alcohol syndrome to increase understanding of the condition in humans.

• Investigated the effects of epigenetic reprogramming on telomere length.

• Developed a new model to study tissue regeneration in mammals.

• Discovered that the Dnmt3L gene is involved in regulating expression of a large number of genes within cells, including gametes.

• Found that a particular missense mutation Foxo3a gene may be involved in ovarian cancer.

Hepatic fibrosisLaboratory Head: Associate Professor Grant Ramm

The Hepatic Fibrosis Laboratory investigates the cellular and molecular mechanisms of scar tissue formation in the liver, such as the iron overload disease haemochromatosis, that leads to fibrosis and cirrhosis in adults, and cystic fibrosis (CF)and biliary atresia in children.

Highlights:

• Demonstrated that liver fibrosis identified via liver biopsy, predicts the future development of clinically significant liver disease (portal hypertension), in children with CF.

• Proved the poor performance of non-biopsy tests currently employed to detect or predict the development of clinically significant CF liver disease.

• Proposed biopsy as the “gold standard” to detect liver scarring and thus this approach should be adopted clinically to better manage patient care and assist in developing more targeted medical interventions in children with CF.

indigenous Health Laboratory Head: Associate Professor Gail Garvey

The Indigenous Health Program aims to promote improved health and wellbeing for Aboriginal and Torres Strait Islander peoples through medical research and education; develop culturally appropriate research projects in partnership with Aboriginal and Torres Strait Islander peoples; cooperate with and assist the work of other agencies to improve the health and wellbeing of Aboriginal and Torres Strait Islander peoples and act as a health advocate.

Highlights:

• Developed a Supportive Care Needs Survey for Indigenous People (SCNS-IP) with cancer. The SCNS-IP tool provides a standardised assessment of the supportive care needs of Indigenous adults with cancer in a culturally appropriate manner.

• Sponsored the National Roundtable on Priorities for Aboriginal and Torres Strait Islander Cancer Research conference in partnership with the Lowitja Institute.

genetic epidemiologyLaboratory Head: Professor Nick Martin

The Genetic Epidemiology Laboratory investigates the pattern of disease in families to assess the relative importance of genes and environment in a variety of important health problems and to locate the genes responsible using genome-wide association analysis.

Highlights:

• Identified two new loci predisposing for asthma risk.

• Discovered a new gene, ITGA4, identified as a major regulator of peripheral blood monocyte counts.

• Demonstrated that many genes contribute to variation in alcohol use and alcohol dependence.

• Discovered gene variants that affect the carbohydrate component of transferrin, the main iron transport protein in plasma.

• Combined personality data with 10 other samples from around the world, leading to the identification of a gene influencing conscientiousness and region associated with a person’s openness to experience.

• Showed that genetic factors influencing the personality trait of neuroticism, a measure of emotional stability, also contribute to symptoms of anxiety and depression and to perceived somatic symptoms.

and wellbeing of Aboriginal and Torres Strait Islander peoples and wellbeing of Aboriginal and Torres Strait Islander peoples and act as a health advocate.and act as a health advocate.

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molecular epidemiologyLaboratory Head: Professor Grant Montgomery

The Molecular Epidemiology Laboratory seeks to identify genes and gene pathways contributing to risk for common human diseases. The laboratory is a world leader in the genetics of endometriosis and works on melanoma, inflammatory bowel disease and a range of other diseases including asthma, migraine, depression, alcohol, nicotine and drug dependence. This laboratory holds a large biobank supporting projects for QIMR’s Genetic Epidemiology, Queensland Statistical Genetics and Neurogenetics Laboratories.

Highlights:

• Published the world’s largest genome-wide association study for endometriosis identifying new risk loci and applied novel methods to confirm a genetic contribution to endometriosis risk and identified a stronger genetic effect in the more severe cases of the disease.

• Identified some of the first genetic variants (on chromosomes 1 and 7) that increase endometriosis risk. Follow up from these discoveries will lead to greater understanding of mechanisms increasing disease risk and help improve treatments.

• Discovered new genes for a range of diseases including Crohn’s disease, ulcerative colitis, endometrial cancer, and glaucoma. Completed a genome-wide search for new genes contributing to melanoma risk, identifying several new leads to follow up.

membrane transportLaboratory Head: Associate Professor Nathan Subramaniam

The Membrane Transport Laboratory studies how iron metabolism is regulated by the liver and has an interest in both basic and applied studies of membrane biology. Identification of the molecules involved in iron metabolism and defining the way they work, has major implications for the treatment of iron-related disorders such as hereditary haemochromatosis and anaemia.

The majority of projects in the laboratory focus on defining how the liver and a number of liver-expressed molecules regulate the absorption, recycling and distribution of iron in the body.

Highlights:

• Showed that in the absence of HFE and TfR2 (genes mutated in hereditary haemochromatosis) the response to inflammation is reduced.

• Demonstrated increased liver iron levels in a mouse model of the cancer-related disorder ataxia-telangiectasia.

• Demonstrated that iron loading leads to increased oxidative stress in livers of ataxia-telangiectasia null mice.

• Identified the first case of ferroportin disease in Australia in an Australian family of Vietnamese origin.

• Demonstrated that the trafficking protein Syntaxin 5 plays an important role in regulating copper levels suggesting that it may be involved in copper-related disorders.

mentaL HeaLtH/compLeX DiSorDerS program | continued

iron metabolismLaboratory Head: Professor Greg Anderson

The Iron Metabolism Laboratory focuses on understanding the homeostasis of iron in the body and the natural history of disorders of iron metabolism such as the iron loading disease haemochromatosis.

Highlights:

• Examined mechanisms of intestinal iron absorption during suckling.

• Defined disease progression and penetrance in hereditary haemochromatosis.

• Showed a critical role for hephaestin and related oxidases in iron absorption.

• Identified factors responsible for regulating iron homeostasis in thalassaemia and other haemolytic anaemias.

• Examined links between iron and gut and lung microbiota is cystic fibrosis.


psychiatric geneticsLaboratory Head: Dr Naomi Wray

The Psychiatric Genetics Laboratory specialises in the development and application of statistical methods and theory to psychiatric disorders and related quantitative traits. The underlying aim is to further our understanding of the causes of these common, complex genetic disorders and in particular, to understand the genetic basis of differences in risk of disease between individuals.

Highlights:

• Published the largest genome-wide association study for major depression showing the disease is underpinned by many variants of small effect size, and implicating the neuropeptide galanin.

• Furthered understanding of the genetic architecture of schizophrenia and major depression, shedding light on future research strategies.

• Challenged the role of synthetic associations in complex genetic disease.

Queensland Statistical genetics Laboratory Laboratory Head: Professor Peter Visscher

The Queensland Statistical Genetics Laboratory (QSTAG) specialises in quantitative and statistical genetics, population genetics, human genetics and bioinformatics, with the ultimate aim of trying to understand the genetic basis of differences in risk to disease and other phenotypes between individuals.

Highlights:

• Shone light on the ‘missing heritability’ problem in complex trait genetics.

• Demonstrated that complex traits, including common diseases and traits such as height and body-mass-index, are caused by the cumulative effect of hundreds of genes.

• Discovered, in conjunction with Australian ophthalmologists, two new genes linked to open angle glaucoma. This discovery will help to identify patients at the highest risk of severe glaucoma.

Systems neuroscience groupLaboratory Head: Professor Michael Breakspear

The Systems Neuroscience Group studies brain sciences by utilising principles across three broad domains – empirical, computational and clinical neuroscience. The overarching aim of this work is to contribute towards unifying mathematical models of brain architecture, dynamics and cognitive function and dysfunction. These models then inform the design of brain imaging experiments to improve our understanding of major mental illnesses.

Highlights:

• Developed a new diagnostic and monitoring test for major depression based on a combination of video and imaging technology.

• Developed a brain stress test for dementia using brain imaging and showed that it could predict the functioning of patients for up to two years.

• Discovered changes in brain activity in healthy young people who were related to patients with bipolar disorder.

neurogeneticsLaboratory Head: Dr Dale Nyholt

The Neurogenetics Laboratory studies the role of genetics in the development and mechanism of the nervous system with the specific goal of identifying genes responsible for neurological disorders, with a primary focus on migraine.

The work includes monitoring the inheritability of relevant genes, establishing DNA markers to find inheritability in family blood samples and identifying common genetic links with other disorders.

Highlights:

• Completed the first Australian genome-wide association study (GWAS) of the more common forms of migraine (migraine with and migraine without aura). This has produced some exciting results that are currently undergoing replication and meta-analysis by international collaborators.

• Published the first GWAS for endometriosis in Caucasian patients that identified two novel susceptibility loci.

• Published the second GWAS for migraine.

Page 69

corporate DivisionDedicated corporate staff are committed to providing the high level of support required to keep QIMR researchers at the forefront of medical research. Consisting of Scientific Services, Finance, Procurement, Grant Management, Human Resources, Regulatory Affairs, Safety, Information Services, Building Services, External Relations and Business Development, the Corporate Division ensures researchers have the services and equipment to undertake world class research.

A focus for the Corporate Division this year has been preparing for the new research facility, which continues to meet budget and timing estimates. In preparation for the opening in 2010, the Bancroft Centre building management system has been upgraded to ensure compatibility with the new facility’s system.

Following the comprehensive IT review in early 2010, the entire network infrastructure has been replaced and

modernised and work continues on implementing a large scale, research data storage solution. A new ethics approval and occupational health and safety system is under development, as is a new grants management system, scheduled for completion late 2011.

QIMR strived to provide the best equipment and scientific and laboratory services for its researchers including media preparation, glassware services, peptide synthesis, DNA sequencing, flow cytometry, histology, microscopy, as well as regulatory and safety services. QIMR committed more than 9% of its 2010–2011 budget to purchasing new and improved equipment, making certain that our researchers are using the most up-to-date tools to ensure efficient and quality outcomes. These included a new PET/CT scanner, Nanodispenser, iScan, Flow Cytometer (Fortessa), BioTek Synergy H4 and ViiA 7 quantitative PCR machine.

In December 2010, QIMR received NHMRC certification for the review process of multi-centre human research thus reducing the administrative burden borne by researchers collaborating with other institutes.

fundraising

Much of QIMR’s research would not be possible without the support of community groups, individuals and corporate sponsors.

QIMR would also like to recognise the contributions from our monthly donors; planned givers who kindly made provision for the Institute in their Wills; and long-term supporters Mrs Marno Parsons AM and Mr Royce Blackburne.

QIMR also welcomed many new supporters through the inaugural Rio Tinto Ride to Conquer Cancer event, which is raising vital funds for cancer research at QIMR. In particular, the Institute would like to thank the event’s major sponsors: Rio Tinto, Sunsuper and the Ausenco Foundation.

Above: Rio Tinto’s Jason Gallagher, John Becker, Tim Lane and Neil Cox with QIMR’s Professor David Whiteman celebrate the announcement of Rio Tinto’s major sponsorship of the inaugural Rio Tinto Ride to Conquer Cancer.

2010–2011 marked the tenth year that Mr Clive Berghofer AM provided substantial support to QIMR.

Above: Chair of QIMR Council Professor John Hay (left) and QIMR Director and CEO Professor Frank Gannon (right) present a commemorative plaque to Mr Clive Berghofer (centre) in recognition of his ten years of outstanding support of the Clive Berghofer Cancer Research Centre at QIMR.

SuppoRtInG ouR ReSeARCH


a special thank you to the following major donors:

• Mr Clive Berghofer AM – Jeteld Pty Ltd

• John Thomas Wilson Foundation (managed by Perpetual)

• The Estate of Kevin Joseph Hill

• William and Hilde Chenhall Research Trust

• Rio Tinto Coal Australia Pty Ltd

• The Estate of Melvin James Anderson

• Sunsuper Pty Ltd

• Suncorp Metway

• The Estate of Brian Musgrove O’Connor

• The Estate of Lila Marian Kenny

• BT Investment Management Pty Ltd

• The Estate of John Francis Pickering

• The Estate of Thelma Josephine Bingham

• Mr Ivan and Mrs Sandra Mitchell

• Mr Royce Blackburne – Roycorp Pty Ltd

• Dr E Glen Truscott

• Mr Leo Weninger

• E M Squires Charitable Trust (managed by Perpetual)

• The Estate of Cathryn Janet Christensen

• Riverside Centre Charity Golf Day (organised by Riverside Centre Management)

• Mrs Marno Parsons AM

• Data #3 Limited

• The Estate of Evelyn Monica Dutton

• Mr Barry and Mrs Maureen Stevenson

• The Pamela Joan Dinning Perpetual Charitable Trust

• The Estate of Esme Joy Shipham

• Sherrin Investments Pty Ltd

• Queensland Community Foundation

• Fitton Insurance Brokers

• Witchery

• Tattersall’s Club

• The Henry Cyril Robjohns and Stella May Robjohns Memorial Trust

• In Vitro Technologies Life Science

• Biniris Pty Ltd

• Happy Face Cent Auctions (organised by Mrs Sunny Drescher)

• Mrs Ailsa Zinns

• Walking on Sunshine event (organised by Mrs Anne Stanton)

• Mrs Helen Gow

• Henderson Foundation

• The Estate of Heather Maldwyn Stoney

• J J Richards and Sons Pty Ltd

• Campbell Brothers Ltd

• Mrs L B Burgess

• Mr Gerry and Mrs Geeske Gerrard (in memory of Peggy Stephens)

• Mr Robert Gerrard (in memory of Peggy Stephens)

• Kenneth Trice Peters Discretionary Will Trust

• Barbara Rhoda Phyllis Dalton Perpetual Charitable Trust Qld

• Mr Peter R Rowland

• The Estate of Camrin Anthony Reeve

• Mr Ronald E Hancock

• Sidney Richard and Beryl Lillian Early Perpetual Trust

• Moran Cup Charity Golf Day (organised by Scott Moran)

• Mr Tim and Mrs Kym Reid

• Mrs Lorraine Duckwitz

• Clipsal Australia Pty Ltd

• Miss Valmai Pidgeon AM

• Selwyn Thomas Fassifern Ozanne and Doreen Elaine Ozanne Trust

• Mr Ron Statham

• Brisbane Girls Grammar School

• The Estate of Elsie Rutter

• Rotary Club of Blackwater

• Reuben Pelerman Benevolent Foundation

• Shop Distributive and Allied Employees Association

• Mr Lindsay Evans

• Mr Douglas and Mrs Helen Cowlishaw

• Mr Kevin and Mrs Elsie Hayes

• Mr Dan Holzapfel

• Mrs Margaret J Gibson

• Mrs Heather Jordan

• Ms Barbara McKay

• The Estate of Ronald Graeme Douglas

• Endometriosis Association (Qld) Inc.

• Mrs Jacqueline Pascual

QIMR’s mental health research received vital funding from Trusts managed by Perpetual.

Above: Mr Andrew Thomas, General Manager of Perpetual Philanthropy (far left) discusses mental health research with Professor Michael Breakspear and Professor Emma Whitelaw. The establishment of this research area was funded by the John Thomas Wilson Endowment and the EM Squires Charitable Trust.

Each year QIMR also acknowledges community members for their outstanding support of medical research. In 2010, recipients of the QIMR Ambassador Awards included: Ms Denise Schellbach, Mr Mark Newman, Ms Carol Ramsay (Suncorp), and Mrs Lorraine Duckwitz.

Another important source of support was generated by individuals and businesses that allocate resources and organise fundraising events benefiting QIMR. Suncorp has supported QIMR’s research for many years and continues to work closely with the Institute on a number of skin cancer related projects.

Page 71

FInAnCIAl StAtementS


operating resultThe operating result for the 2010–2011 financial year was a surplus of $137,867k (2009–2010: $19,978k) after providing for depreciation of $5,412k. This surplus includes recognition of capital grants from Commonwealth Government, Queensland State Government, and The Atlantic Philanthropies towards the construction of the Smart State Medical Research Centre ($71,840k), and a gain on the transfer of net assets of the former QIMR Trust that was abolished 1 February 2011 ($54,985k).

QIMR’s financial structure is based on the management of core and grant funds. Funding for competitive research grants for the 2010-11 financial year was $40,218k (2009-10: $44,209k), representing 53% of total comprehensive income, excluding capital grants and gain from abolition of QIMR Trust (2009-10: 60%). A majority of the Institute’s core funding is provided through a grant from Queensland Health $13,969k (2009-10: $6,169k).

QIMR’s total funding resources, including amounts under management at 30 June 2011 totalled $172,269k (2009-10: $94,633k), of which $66,550k was represented by capital grants (2009-10: $57,511k). The increase in funds held during the year is mainly due to transfer of cash and investments from the abolished QIMR Trust, and capital grants received in relation to the Smart State Medical Research Centre.

Construction of the Smart State Medical Research Centre is fully funded with total contributions from Commonwealth Government ($110M), Queensland State Government ($35M), and The Atlantic Philanthropies ($27.5M). Occupation of the new building is scheduled for early 2012.

abolition of Qimr trustThe Queensland Institute of Medical Research Act 1945 was amended by legislation, entitled the Water and Other Legislation Amendment Act 2010, enacted and assented to by the Queensland Parliament on 25 November 2010. As per section 137 of the Amendment Act, the Trust was abolished with effect on 1 February 2011, with the responsibilities of the Trust transferred to the Council of the Queensland Institute of Medical Research as of the abolition date. To support this transfer, total assets valued at $55.116 million and total liabilities valued at $0.131 million were transferred to the Council at 31 January 2011.

consultanciesCategory Summary $

Business Services Global Philanthropic engaged to provide fundraising services to assist QIMR in managing donor relations with supporters of its Hong Kong research program.

$16,800

financial documentationThe financial reports should include the following documentation:

• Final Financial Statements as audited by QAO, in line with Treasury’s Financial Reporting Requirements for Govt Agencies;

• Certification of Final Financial Statements, in line with the Financial Accountability Act (s62) and FPMS 2009 (s42,43 + 50);

• Independent Auditors Report, in line with the Financial Accountability Act (s62) and FPMS 2009 (s50); and

• Remuneration Disclosures, in line with Financial Reporting Requirements for Qld Government Agencies.

Page 73

tHe counciL of tHe QueenSLanD inStitute of meDicaL reSearcH

financiaL StatementS 2010-11

contents

• Statement of Comprehensive Income

• Statement of Financial Position

• Statement of Changes in Equity

• Statement of Cash Flows

• Notes To and Forming Part of the Financial Statements

• Management Certificate

general informationThese financial statements cover the Queensland Institute of Medical Research and its jointly controlled entities.

The Queensland Institute of Medical Research is a Queensland statutory body established under the Queensland Institute of Medical Research Act 1945.

The statutory body is controlled by the State of Queensland which is the ultimate parent.

The head office and principal place of business of the statutory body is:

300 Herston Rd, Herston QLD 4006

A description of the nature of the Council’s operations and its principal activities is included in the notes to the financial statements.

For information in relation to the statutory body’s financial statements please call +61 7 3362 0222, email [email protected] or visit the statutory bodies’s website www.qimr.edu.au

Amounts shown in these financial statements may not add to the exact sub-totals or totals due to rounding.


The Council of The Queensland Institute of Medical Research Statement of Comprehensive Income

Notes 2011 2010

$'000 $'000

Grants and other contributions 2 137,835 75,623

User charges 3 4,386 5,204

Other revenue 4 9,950 10,776

Total Revenue 152,171 91,603

Gains 5 53,932 990

206,103 92,593

6 39,892 39,920

7 18,106 23,359

8 5,412 5,272

9 4,496 3,879

Finance Costs 141 56

Share of loss of equity accounted investees 24 189 130

68,236 72,616

137,867 19,977

19 (1,480) (5,290)

(1,480) (5,290)

Total Comprehensive Income 136,387 14,687

The accompanying notes form part of these statements.

Income from Continuing Operations

Total Income from Continuing Operations

Expenses from Continuing Operations

Total Other Comprehensive Income

Other Comprehensive Income

Increase (decrease) in asset revaluation surplus

Employee expenses

Supplies and services

Depreciation and amortisation

Other expenses

Operating Result from Continuing Operations

Total Expenses from Continuing Operations

Statement of comprehensive income for the year ended 30 June 2011the council of the Queensland institute of medical research

Page 75

The Council of The Queensland Institute of Medical Research Statement of Financial Position

Notes 2011 2010

$'000 $'000

Current Assets

Cash and cash equivalents 10 112,453 80,648

Receivables 11 10,488 8,346

Inventories 12 277 269

Prepayments 398 752

Total Current Assets 123,616 90,015

Non Current Assets

Other financial assets 13 59,863 14,031

Intangible assets 14 722 786

Property, plant and equipment 15 206,287 132,822

Investments accounted for using the equity method 24 301 490

Total Non Current Assets 267,173 148,129

Total Assets 390,789 238,144

Current Liabilities

Payables 16 10,804 7,381

Accrued employee benefits 17 3,104 3,213

Unearned revenue 18 87,243 74,406

Total Current Liabilities 101,151 85,000

Non Current Liabilities

Accrued employee benefits 17 870 763

Total Non Current Liabilities 870 763

Total Liabilities 102,021 85,763

Net Assets 288,768 152,381

Equity

Accumulated surplus 249,641 111,774

Asset revaluation surplus 19 39,127 40,607

Total Equity 288,768 152,381


Statement of financial position as at 30 June 2011the council of the Queensland institute of medical research


The Council of The Queensland Institute of Medical Research Statement of Changes in Equity

Accumulated Surplus

Asset Revaluation

Surplus (Note 19)

TOTAL

$'000 $'000 $'000

Balance as at 1 July 2009 91,797 45,897 137,694

Operating Result from Continuing Operations 19,977 - 19,977


Increase/(decrease) in Asset Revaluation Surplus - (5,290) (5,290)

Balance as at 30 June 2010 111,774 40,607 152,381

Balance as at 1 July 2010 111,774 40,607 152,381

Operating result from Continuing Operations 137,867 - 137,867


Increase/(decrease) in Asset Revaluation Surplus - (1,480) (1,480)

Balance as at 30 June 2011 249,641 39,127 288,768


Statement of changes in equity for the year ended 30 June 2011the council of the Queensland institute of medical research

Page 77

The Council of The Queensland Institute of Medical Research Statement of Cash Flows

Notes 2011 2010

$'000 $'000

Cash flows from operating activities

Inflows:

Grants and other contributions 150,889 66,462

User charges 4,152 6,392

Other income 6,328 10,229

GST collected (640) (178)

Outflows:

Employee expenses (39,644) (39,592)

Supplies and services (18,489) (23,801)

Finance costs (141) (56)

GST paid (71) (223)

Other (4,438) (3,879)

Net cash provided by (used in) operating activities 20 97,946 15,354

Cash flows from investing activities

Inflows:

Sales of property, plant and equipment 1,049 4

Proceeds from sales of other financial assets 9,671 18,919

Outflows:

Payments for property, plant and equipment (77,512) (19,236)

Net cash provided by (used in) in investing activities (66,792) (313)

Net increase (decrease) in cash and cash equivalents 31,154 15,041

Cash and cash equivalents at beginning of financial year 80,648 65,607

Cash and cash equivalent transferred from QIMR Trust 651

Cash and cash equivalents at end of financial year 10 112,453 80,648


Statement of cash flows for the year ended 30 June 2011the council of the Queensland institute of medical research


The Council of The Queensland Institute of Medical Research Notes to and forming part of the financial statements 2010-11

Objectives and Principal Activities of the Council

Note 1: Summary of Significant Accounting Policies

Note 2: Grants and other contributions

Note 3: User charges

Note 4: Other revenue

Note 5: Gains

Note 6: Employee expenses

Note 7: Supplies and services

Note 8: Depreciation and amortisation

Note 9: Other expenses

Note 10: Cash and cash equivalents

Note 11: Receivables

Note 12: Inventories

Note 13: Other financial assets

Note 14: Intangible assets `Note 15 Property, plant and equipment

Note 16: Payables

Note 17: Accrued employee benefits

Note 18: Unearned revenue

Note 19: Asset revaluation surplus by class

Note 20: Reconciliation of operating surplus to net cash from operating activities

Note 21: Non-cash financing and investing activities

Note 22: Commitments for expenditure

Note 23: Contingencies

Note 24: Jointly controlled entities

Note 25: Trust transactions and balances

Note 26: Key executive management personnel and remuneration

Note 27:

Note 28: Financial instruments

Note 29: Events Occurring After Balance Date

Note 30: Changes in Accounting Estimates and Correction of Errors

Transfer of the assets and liabilities of the abolished QIMR Trust to the Council ofthe Queensland Institute of Medical Research

notes to and forming part of the financial statements 2010–11the council of the Queensland institute of medical research

Page 79

Objective and Principal Activities of the Council

1. Summary of Significant Accounting Policies

(a) Statement of Compliance

(b) The Reporting Entity

(c) Investment in Joint Ventures

(d) Trust Transactions and Balances

(e) Grants and other contributions

The Smart State Medical Research Centre project has been funded with total contributions from FederalGovernment $110m, Queensland State Government $35m and Atlantic Philanthropies $27.5m.

These financial statements are general purpose financial statements, and have been prepared on an accrual basisin accordance with Australian Accounting Standards and Interpretations. In addition, the financial statements haveregard to Treasury's Minimum Reporting Requirements for the year ending 30 June 2011, and other authoritativepronouncements.

Grants, contributions, donations, bequests, gifts and fundraising that are non-reciprocal in nature are recognisedas revenue in the year in which the Council obtains control over them. Where grants are received that are reciprocalin nature, revenue is recognised over the term of the funding arrangements.

As the Council acts only in a custodial role in respect of these transactions and balances, they are not recognisedin the financial statements, but are disclosed in Note 25.

The Council undertakes certain trustee transactions on behalf of CRC Vaccine Technology and QIMR employeeresearch activities.

The interest of the Council in its joint ventures is brought to account by using the equity method of accountingwhereby the investment is initially recognised at cost and adjusted thereafter for the post-acquisition change in theCouncil's share of net assets of the joint venture. In addition, the Council's share of the profit or loss of the jointventure is included in the Council's operating result. Vaccine Solutions Pty Ltd is not equity accounted as QIMR hasno claim over of joint venture. Further details of the Council's interest in jointly controlled operations are contained innote 24.

Jointly controlled entities are those where the Council has joint control, established by contractual agreement. Asat 30 June 2011, the Council has entered into two material joint ventures — Vaccine Solutions Pty Ltd and Q-PharmPty Ltd.

The financial statements include the value of all revenues, expenses, assets, liabilities and equity of the Council.The Council has no material controlled entities as at 30 June 2011.

With respect to compliance with Australian Accounting Standards and Interpretations, the Council has appliedthose requirements applicable to not-for-profit entities, as the Council is a not-for-profit statutory body. Exceptwhere stated, the historical cost convention is used.

The Council has prepared this financial report in compliance with section 43 of the Financial and PerformanceManagement Standard 2009 .

The Council receives an operational grant from Queensland Health on an annual basis. The majority of theInstitute's funding is generated from competitive, peer reviewed research grants, commercial and other earnedrevenue. Funds are also received from donation, fundraising and investment activities performed by the Instituteunder the guidance of the Council.

Contributed assets are recognised at their fair value. Contributions of services are recognised only when a fairvalue can be determined reliably and the services would be purchased if they had not been donated.

The objective of the Council is to control and manage the Queensland Institute of Medical Research (the Institute).The Institute has been established to conduct research into all branches of medical science. The Institute operatespredominantly in one geographical area, being Queensland, Australia, although it has research collaborations inAustralia and overseas.


value can be determined reliably and the services would be purchased if they had not been donated.value can be determined reliably and the services would be purchased if they had not been donated.value can be determined reliably and the services would be purchased if they had not been donated.


(f) User Charges and recoveries

(g) Interest, Dividends and Distributions

(h) Imputation credits

(i) Cash and cash equivalents

(j) Receivables

(k) Inventories

(l) Acquisitions of Assets

Assets acquired at no cost or for nominal consideration, other than from an involuntary transfer from anotherQueensland Government entity, are recognised at their fair value at date of acquisition in accordance with AASB116 Property, Plant and Equipment.

Where assets are received free of charge from another Queensland Government entity, the acquisition cost isrecognised as the gross carrying amount in the books of the transferor immediately prior to the transfer togetherwith any accumulated depreciation.

Actual cost is used for the initial recording of all non-current physical and intangible asset acquisitions. Cost isdetermined as the value given as consideration plus costs incidental to the acquisition, including all other costsincurred in getting the assets ready for use, including architects' fees and engineering design fees. However, anytraining costs are expensed as incurred.

No inventory assets have been classified as inventories held for distribution.

Inventories are represented by consumable laboratory supplies valued at the lower of cost and net realisable value.

Net realisable value is determined by estimating the selling price in the ordinary course of business, less theestimated costs of completion and selling expenses.

Cost is assigned on a weighted average basis and includes expenditure incurred in acquiring the inventories andbringing them to their existing condition, except for training costs which are expensed as incurred.

For the purposes of the Statement of Financial Position and the Statement of Cash Flows, cash assets include allcash and cheques receipted but not banked at 30 June as well as deposits at call with financial institutions.

Revenue for interest is recognised and allocated over the reporting period by employment of the effective interestmethod. Revenue for dividends and distributions from managed funds classified as financial instruments held at fairvalue through profit or loss are recognised when the Council's right to receive payment is established.

User charges and fees from commercial services and recoveries of expenditure incurred by associated bodieswhich use QIMR laboratory consumables and services, controlled by the Council, are recognised as revenueswhen the revenue has been earned and can be measured reliably with a sufficient degree of certainty. This involveseither invoicing for related goods/services and/or the recognition of accrued revenue. User charges and fees arecontrolled by the Council where they can be deployed for the achievement of departmental objectives.

As an endorsed income tax exempt charity, imputation credits attached to franked dividends received by theCouncil are refundable and may be claimed retrospectively after the end of the financial year. Imputation creditsare brought to account when the right to receive the credits is established.

The collectability of receivables is assessed periodically with provision being made for impairment. All known baddebts were written-off as at 30 June.

Other debtors generally arise from transactions outside the usual operating activities of the Council and arerecognised at their assessed values. Terms are a maximum of one month, no interest is charged and no security isobtained.

Trade debtors are recognised at the amounts due at the time of sale or service delivery i.e. the agreedpurchase/contract price. Settlement of these amounts is required within 30 days from invoice date.


Page 81

(m) Property, Plant and Equipment

Buildings $10,000

Plant and Equipment $5,000

Other (including heritage & cultural) $5,000

(n) Revaluations of Non-Current Physical and Intangible Assets

(o) Intangibles

Purchased Software

Internally Generated Software

Items with a lesser value are expensed in the year of acquisition.

Items of property, plant and equipment with a cost or other value equal to or in excess of the following thresholdsare recognised for financial reporting purposes in the year of acquisition:

Non-current physical assets measured at fair value are independently re-valued by an external registered valuer atleast once every five years with interim valuations, using appropriate indices, being otherwise performed on anannual basis where there has been a material variation in the index. Refer to note 15 for details.

Where intangible assets have an active market, they are measured at fair value, otherwise they are measured atcost.

Buildings and heritage and cultural assets are measured at fair value in accordance with AASB 116 Property, Plantand Equipment and Queensland Treasury’s Non-Current Asset Policies for the Queensland Public Sector . Inrespect of these asset classes, the cost of items acquired during the financial year has been judged bymanagement of the Council to materially represent their fair value at the end of the reporting period.

Intangible assets with a cost or other value equal to or greater than $100,000 are recognised in the balance sheet,items with a lesser value being expensed. Each intangible asset, less any anticipated residual value, is amortisedover its estimated useful life to the council. The residual value is zero for all the council's intangible assets.

Costs associated with the development of computer software have been capitalised and are amortised on a straightline basis over the period of expected benefit to the council, namely 10 years.

Expenditure on research activities relating to internally-generated intangible assets is recognised as an expense inthe period in which it is incurred.

The purchase cost of this software has been capitalised and is being amortised on a straight-line basis over theperiod of the expected benefit to the council, namely 10 years.

It has been determined that there is not an active market for any of the Council's intangible assets. As such, theassets are recognised and carried at cost less accumulated amortisation and accumulated impairment losses.

Plant and equipment is measured at cost in accordance with Treasury's Non-Current Asset Policies .

No intangible assets have been classified as held for sale or form part of a disposal group held for sale.

On revaluation, accumulated depreciation is restated proportionately with the change in the carrying amount of theasset and any change in the estimate of remaining useful life.

Any revaluation increment arising on the revaluation of an asset is credited to the asset revaluation surplus of theappropriate class, except to the extent it reverses a revaluation decrement for the class previously recognised asan expense. A decrease in the carrying amount on revaluation is charged as an expense, to the extent it exceedsthe balance, if any, in the revaluation surplus relating to that asset class.

Materiality concepts under AASB 1031 Materiality are considered in determining whether the difference betweenthe carrying amount and the fair value of an asset is material.

Separately identified components of assets are measured on the same basis as the assets to which they relate.



(p) Amortisation and Depreciation of Intangibles and Property, Plant and Equipment

Class Rate %

Buildings 2

Plant and equipment:

Motor Vehicles 20

Scientific equipment 5 - 33.3

Leasehold improvements 4

Other equipment 5 - 33.3

Intangible Assets:

Software Purchased 10

Software Internally Generated 10

(q) Impairment of Non-Current Assets

Where an impairment loss subsequently reverses, the carrying amount of the asset is increased to the revisedestimate of its recoverable amount, but so that the increased carrying amount does not exceed the carrying amountthat would have been determined had no impairment loss been recognised for the asset in prior years. A reversal ofan impairment loss is recognised as income, unless the asset is carried at a re-valued amount, in which case thereversal of the impairment loss is treated as a revaluation increase. Refer also note 1(n).

For each class of depreciable asset the following depreciation and amortisation rates are used:

Any expenditure that increases the originally assessed capacity or service potential of an asset is capitalised andthe new depreciable amount is depreciated over the remaining useful life of the asset to the Council.

Where assets have separately identifiable components that are subject to regular replacement, these componentsare assigned useful lives distinct from the asset to which they relate and are depreciated accordingly.

Assets under construction (work-in-progress) are not depreciated until they reach service delivery capacity. Servicedelivery capacity relates to when construction is complete and the asset is first put to use or is installed ready foruse in accordance with its intended application. These assets are then reclassified to the relevant classes withinproperty, plant and equipment.

Common use items of the Institute's research library are expensed on acquisition. Heritage and cultural assetsinclude research library monographs, Australiana and scarce items. The service potential of these assets is notexpected to diminish with time or use and therefore, they are not depreciated.

Property, plant and equipment is depreciated on a straight-line basis so as to allocate the net cost or re-valuedamount of each asset, less its estimated residual value, progressively over its estimated useful life to the council.

All non-current physical and intangible assets are assessed for indicators of impairment on an annual basis. If anindicator of possible impairment exists, the Council determines the asset's recoverable amount. Any amount bywhich the asset's carrying amount exceeds the recoverable amount is recorded as an impairment loss.

All intangible assets of the council have finite useful lives and are amortised on a straight line basis.

An impairment loss is recognised immediately in the Statement of Comprehensive Income, unless the asset iscarried at a re-valued amount. When the asset is measured at a re-valued amount, the impairment loss is offsetagainst the asset revaluation surplus of the relevant class to the extent available.

The asset's recoverable amount is determined as the higher of the asset's fair value less costs to sell anddepreciated replacement cost.

The depreciable amount of improvements to or on leasehold land is allocated progressively over the estimateduseful lives of the improvements or the unexpired period of the lease, whichever is the shorter. The unexpiredperiod of a lease includes any option period where exercise of the option is probable.


Page 83

(r) Leasehold Improvements

The Council currently erected a new building. Costs are in work in progress.

(s) Leases

(t) Other Financial Assets

(u) Payables

(v) Financial Instruments

Recognition

Classification

iv) Payables - held at amortised cost

iii) Other financial assets - held at fair value through profit or loss

Operating lease payments are representative of the pattern of benefits derived from the leased assets and areexpensed in the periods in which they are incurred.

The costs of leasehold improvements relating to these properties will be amortised over the remaining period of thelease, or the estimated useful life to the Institute, whichever is shorter.

ii) Receivables - held at amortised cost

i) Cash and cash equivalents - held at fair value through profit or loss

Other financial assets held at fair value through profit or loss represent investments in managed funds and sharesin listed and unlisted companies. The investments are stated at current market value at the reporting date. Changesin the market value of these instruments, whether realised or unrealised, are recognised in the Statement ofComprehensive Income. These investments were originally classified as at fair value through profit or loss uponinitial recognition and the Council manages these investments and makes purchases and sales decisions based ontheir fair value in accordance with the Council's documented investment strategy.

Incentives received on entering into operating leases are recognised as liabilities. Lease payments are allocatedbetween rental expense and reduction of the liability.

Lease payments are allocated between the principal component of the lease liability and the interest expense.

The Queensland Institute of Medical Research occupies two buildings situated on Crown land reserved and setapart for hospital purposes and under the control of Queensland Health on behalf of the State of Queensland.

Where a non-current physical asset is acquired by means of a finance lease, the asset is recognised at the lower ofthe fair value of the leased property and the present value of the minimum lease payments. The lease liability isrecognised at the same amount.

A distinction is made in the financial statements between finance leases that effectively transfer from the lessor tothe lessee substantially all risks and benefits incidental to ownership, and operating leases, under which the lessorretains substantially all risks and benefits.

Financial instruments are classified and measured as follows:

Financial assets and financial liabilities are recognised in the Statement of Financial Position when the Councilbecomes party to the contractual provisions of the financial instrument.

Trade creditors are recognised upon receipt of the goods or services ordered and are measured at the nominalamount i.e. agreed purchase/contract price, gross of applicable trade and other discounts. Amounts owing areunsecured and are generally settled on 30 day terms.

A lease for the land and building known as The Clive Berghoffer Cancer Research Centre exists between theInstitute and The State of Queensland (represented by the Department of Health), at a nominal rental, terminatingon 27 June 2066. The building was constructed by the Council using grants from the Federal and Queensland StateGovernments, and private donors.

A lease for the land and building known as the Bancroft Centre exists between the Institute and The State ofQueensland (represented by the Department of Health), at a nominal rental, terminating on 27 June 2066. TheBancroft Centre was constructed by the Council using grants from the Federal and Queensland State Government.


iv) Payables - held at amortised cost


iv) Payables - held at amortised costiv) Payables - held at amortised cost



(w) Employee Benefits

Key executive management personnel and remuneration disclosures are made in accordance with the section 5Addendum (issued in May 2011) to the Financial Reporting Requirements for Queensland Government Agenciesissued by Queensland Treasury. Refer to note 26 for the disclosures on key executive management personnel andremuneration.

The QSuper scheme has defined benefit and defined contribution categories. The liability for defined benefits isheld on a whole-of-government basis and reported in those financial statements pursuant to AASB 1049 Whole ofGovernment and General Government Sector Financial Reporting .

Employer superannuation contributions are paid to QSuper, the superannuation scheme for QueenslandGovernment employees, at rates determined by the Treasurer on the advice of the State Actuary. Contributions areexpensed in the period in which they are paid or payable. The council's obligation is limited to its contribution toQSuper.

No provision for long service leave is recognised in the Council's financial statements, the liability being held on awhole-of-government basis and reported in those financial statements pursuant to AASB 1049 Whole ofGovernment and General Government Sector Financial Reporting .

Under the Queensland Government’s long service leave scheme, a levy is made on the statutory body to cover thecost of employees' long service leave. The levies are expensed in the period in which they are payable. Amountspaid to employees for long service leave are claimed from the scheme quarterly in arrears.

As sick leave is non-vesting, an expense is recognised for this leave as it is taken.

Prior history indicates that on average, sick leave taken each reporting period is less than the entitlement accrued.This is expected to continue in future periods. Accordingly, it is unlikely that existing accumulated entitlements willbe used by employees and no liability for unused sick leave entitlements is recognised.

For unpaid entitlements expected to be paid within 12 months, the liabilities are recognised at their undiscountedvalues. Entitlements not expected to be paid within 12 months are classified as non-current liabilities andrecognised at their present value, calculated using yields on Fixed Rate Commonwealth Government bonds ofsimilar maturity, after projecting the remuneration rates expected to apply at the time of likely settlement.

Wages, salaries and annual leave due but unpaid at reporting date are recognised in the Statement of FinancialPosition at the current salary rates.

Payroll tax and workers' compensation insurance are a consequence of employing employees, but are not countedin an employee's total remuneration package. They are not employee benefits and are recognised separately asemployee related expenses.

Employer superannuation contributions, annual leave and long service leave levies are regarded as employeebenefits.

All other disclosures relating to the measurement and financial risk management of financial instruments held by theCouncil are included in Note 28.

The Council does not enter into transactions for hedging purposes.

Superannuation

Wages, Salaries and Annual Leave and Sick Leave

Long Service Leave

Key executive management personnel and remuneration


Page 85

(x) Provisions

(y) Insurance

(z) Services Received Free of Charge or for Nominal Value

(aa) Taxation

(ab) Issuance of Financial Statements

(ac) Judgements

(ad) Rounding and Comparatives

(ae) New and Revised Accounting Standards

Provisions are recorded when Council has a present obligation, either legal or constructive as a result of a pastevent. They are recognised at the amount expected at reporting date for which the obligation will be settled in afuture period. Where the settlement of the obligation is expected after 12 or more months, the obligation isdiscounted to the present value using an appropriate discount rate. However, no present obligations have beenidentified by Council requiring the recognition of provision as at 30 June 2011.

The preparation of financial statements necessarily requires the determination and use of certain critical accountingestimates, assumptions, and management judgements that have that potential to cause a material adjustment to thecarrying amounts of assets and liabilities within the next financial year. Such estimates, judgements and underlyingassumptions are reviewed on an ongoing basis. Revisions to accounting estimates are recognised in the period inwhich the estimate is revised and in future periods as relevant.

The financial statements are authorised for issue by the Chairman of Council, Director and Secretary at the date ofsigning the Management Certificate.

The Council is a State body as defined under the Income Tax Assessment Act 1936 and is exempt fromCommonwealth taxation with the exception of Fringe Benefits Tax (FBT) and Goods and Services Tax (GST). FBTand GST are the only taxes accounted for by the Council. GST credits receivable from, and GST payable to theATO, are recognised (refer to note 11).

Contingencies - note 23

Valuation of Property, Plant and Equipment - notes 1(n) and 15

Estimates and assumptions that have a potential significant effect are outlined in the following financial statementnotes:

At the date of authorisation of the financial report, significant impacts of new or amended Australian accountingstandards with future commencement dates are as set out below.

The Council is not permitted to early adopt a new or amended accounting standard ahead of the specifiedcommencement date unless approval is obtained from the Treasury Department. Consequently, the Council has notapplied any Australian accounting standards and interpretations that have been issued but are not yet effective.The Council applies standards and interpretations in accordance with their respective commencement dates.

The Council did not voluntarily change any of its accounting policies during 2010-11. No amendments to theAustralian accounting standards applicable for the first time for 2010-11 were relevant to the Council's financialstatements.

Amounts included in the financial statements are in Australian dollars and have been rounded to the nearest $1,000or, where that amount is $500 or less, to zero, unless disclosure of the full amount is specifically required.

Comparative information has been restated where necessary to be consistent with disclosures in the currentreporting period.

Contributions of services are recognised only if the services would have been purchased if they had not beendonated and their fair value can be measured reliably. Where this is the case, an equal amount is recognised asrevenue and an expense.

The Council's non-current physical assets and other risks are insured through the Queensland GovernmentInsurance Fund, premiums being paid on a risk assessment basis. In addition, the Council pays premiums toWorkCover Queensland in respect of its obligations for employee compensation.


At the date of authorisation of the financial report, significant impacts of new or amended Australian accountingstandards with future commencement dates are as set out below.At the date of authorisation of the financial report, significant impacts of new or amended Australian accountingstandards with future commencement dates are as set out below.At the date of authorisation of the financial report, significant impacts of new or amended Australian accountingstandards with future commencement dates are as set out below.At the date of authorisation of the financial report, significant impacts of new or amended Australian accountingstandards with future commencement dates are as set out below.At the date of authorisation of the financial report, significant impacts of new or amended Australian accountingstandards with future commencement dates are as set out below.At the date of authorisation of the financial report, significant impacts of new or amended Australian accountingAt the date of authorisation of the financial report, significant impacts of new or amended Australian accounting


All other Australian accounting standards and interpretations with future commencement dates are either notapplicable to the council's activities, or have no material impact on the council.

Pursuant to AASB 1053, public sector entities like the Council of the Queensland Institute of Medical Research mayadopt tier 2 requirements for their general purpose financial statements. However, AASB 1053 acknowledges thepower of a regulator to require application of the tier 1 requirements. In the case of the Council, the TreasuryDepartment is the regulator. Treasury Department has advised that its policy decision is that statutory bodiescaptured within the whole-of-government financial statements require all to adopt tier 1 reporting requirements. Incompliance with Treasury's policy which prohibits the early adoption of new or revised accounting standards unlessTreasury approval is granted, the Council has not early adopted AASB 1053.

Tier 1 requirements comprise the full range of AASB recognition, measurement, presentation and disclosurerequirements that are currently applicable to reporting entities in Australia. The only difference between the tier 1and tier 2 requirements is that tier 2 requires fewer disclosures than tier 1. AASB 2010-2 sets out the details ofwhich disclosures in standards and interpretations are not required under tier 2 reporting.

AASB 1053 Application of Tiers of Australian Accounting Standards and AASB 2010-2 Amendments to AustralianAccounting Standards arising from Reduced Disclosure Requirements [AASB 1, 2, 3, 5, 7, 8, 101, 102, 107, 108,110, 111, 112, 116, 117, 119, 121, 123, 124, 127, 128, 131, 133, 134, 136, 137, 138, 140, 141, 1050 & 1052 andInterpretations 2, 4, 5, 15, 17, 127, 129, & 1052] apply to reporting periods beginning on or after 1 July 2013. AASB1053 establishes a differential reporting framework for those entities that prepare general purpose financialstatements, consisting of two tiers of reporting requirements – Australian Accounting Standards (commonly referredto as “tier 1”), and Australian Accounting Standards – Reduced Disclosure Requirements (commonly referred to as“tier 2”).

On initial application of AASB 9, the Council will need to re-assess the measurement of its financial assets againstthe new classification and measurement requirements, based on the facts and circumstances that exist at that date. Assuming no change in the types of transactions the Council enters into, it is not expected that any of the Council'sfinancial assets will meet the criteria in AASB 9 to be measured at amortised cost. Therefore, as from the 2013-14financial statements, all of the Council's financial assets will be required to be classified as "financial assetsrequired to be measured at fair value through profit or loss" (instead of the measurement classifications presentlyused in notes 1(v) and 31). The same classification will be used for net gains/losses recognised in the Statement ofComprehensive Income in respect of those financial assets. In the case of the Council's receivables, the carryingamount is considered to be a reasonable approximation of fair value.

AASB 9 Financial Instruments (December 2010) and AASB 2010-7 Amendments to Australian AccountingStandards arising from AASB 9 (December 2010) [AASB 1, 3, 4, 5, 7, 101, 102, 108, 112, 118, 120, 121, 127, 128,131, 132, 136, 137, 139, 1023 & 1038 and Interpretations 2, 5, 10, 12, 19 & 127] become effective from reportingperiods beginning on or after 1 January 2013. The main impacts of these standards on the Council are that they willchange the requirements for the classification, measurement and disclosures associated with financial assets.Under the new requirements, financial assets will be more simply classified according to whether they aremeasured at either amortised cost or fair value. Pursuant to AASB 9, financial assets can only be measured atamortised cost if two conditions are met. One of these conditions is that the asset must be held within a businessmodel whose objective is to hold assets in order to collect contractual cash flows. The other condition is that thecontractual terms of the asset give rise on specified dates to cash flows that are solely payments of principal andinterest on the principal amount outstanding.

Also, for those financial assets that are either past due but not impaired, or have been individually impaired, therewill be no need to separately disclose details about any associated collateral or other credit enhancements held bythe Council.

AASB 2010-4 Further Amendments to Australian Accounting Standards arising from the Annual ImprovementsProject [AASB 1, AASB 7, AASB 101 & AASB 134 and Interpretation 13] becomes effective from reporting periodsbeginning on or after 1 January 2011. The Council will then need to make changes to its disclosures about creditrisk on financial instruments in note 28(c). No longer will the Council need to disclose amounts that best representan entity’s maximum exposure to credit risk where the carrying amount of the instruments reflects this. If the Councilholds collateral or other credit enhancements in respect of any financial instrument, it will need to disclose - byclass of instrument - the financial extent to which those arrangements mitigate the credit risk. There will be no needto disclose the carrying amount of financial assets for which the terms have been renegotiated, which wouldotherwise be past due or impaired.


applicable to the council's activities, or have no material impact on the council.applicable to the council's activities, or have no material impact on the council.

Page 87

2011 2010

$'000 $'000

2. Grants and other contributions

Grants

Grants- Queensland Health* 13,969 6,169

Grants- QIMR Trust- Research support 1,164 4,417

Grants - Other 40,219 44,209

Grants - RBWH - 953

Grants - Smart State Medical Research Centre* * 71,840 14,849

Grants - NHMRC Infrastructure Funding ^ 4,765 5,011

Donations and fundraising 5,586 15

Bequests 292 -

Total 137,835 75,623

3. User charges

Commercial and contract research 1,912 1,966

Sundry tenants recoveries 1,869 2,551

Other 605 687

Total 4,386 5,204

4. Other revenue

Interest 2,115 1,185

Interest-Smart State Medical Research Centre 3,242 4,288

Investment distributions 3,416 781

Reimbursements 1,028 4,488

Other 149 34

Total 9,950 10,776

* Included in revenue from grants for 2011 is a grant of $13.969 million from Queensland Health. The terms ofthe grant are that it must be used to fund the administrative operations and maintenance of the Institutethroughout the reporting period. The recognition of revenue has been deferred upon receipt with revenuerecognised over the term of the funding arrangement. At 30 June 2011, all of the grant had been spent.

^ Included in revenue from grants for 2011 is a grant of $4.765 million from the National Health and MedicalResearch Council. The terms of the grant are that it must be used to fund capital scientific equipmentacquisitions and maintenance of the Institute. The recognition of revenue has been deferred upon receipt withrevenue recognised over the term of the funding arrangement. At 30 June 2011, all of the grant had beenspent.

** Included in revenue from grants for 2011 are milestone grant payments of $10 million from the QueenslandDepartment of Employment, Economic Development and Innovation, $55.5 million from the CommonwealthDepartment of Education, Employment and Workplace Relations' Education Investment Fund, and $5.5 millionfrom the Atlantic Philanthropies Group. The terms of these grants are that these moneys must be used to fundthe construction and fit out of the QIMR Smart State Research Centre building on the Herston site. Therecognition of revenue has been deferred upon receipt with revenue recognised over the term of the fundingarrangement. At 30 June 2011, $66.550 million of the grant remained unspent.



2011 2010

$'000 $'000

5. Gains

Net gain on market value of other financial asset (1,053) 683

Net gain on sale of property, plant and equipment - 4

Net gain on foreign exchange transactions - 303

Net gain on transfer of QIMR Trust net assets to Council (note 27) 54,985 -

Total 53,932 990

6. Employee expenses

Employee benefits

Wages and salaries 32,051 32,162

Employer superannuation contributions * 3,744 3,740

Long service leave levy * 632 512

Annual leave expense * 3,040 3,104

Other employee benefits 241 272

Employee related expenses

Workers' compensation premium * 73 9

Fringe benefits tax expense 36 31

Other employee related expenses 75 90

Total 39,892 39,920

* Refer to note 1(w)

Number of Employees: 448 453

7. Supplies and services

Consultants and contractors 3,221 7,655

Supplies and consumables 12,127 13,038

Travel 1,793 1,755

Minor equipment and software purchases 782 700

Rent 183 211

18,106 23,359

The number of employees including both full-time employees and part-time employees measured on a full-time equivalent basis is:

Total


Page 89

2011 2010

$'000 $'000

8. Depreciation and amortisation

Depreciation and amortisation were incurred in respect of:

Buildings 2,373 2,561

Plant and equipment 2,954 2,667

Software purchased 68 42

Software internally generated 17 2

Total 5,412 5,272

9. Other expenses

Scientific collaboration distributions 3,714 3,285

Audit fee* 182 107

Insurance 380 335

Legal expenses 112 103

Net loss on sale of property, plant and equipment 59 -

Net loss on foreign exchange transactions 33 -

Impairment of bad debts 16 -

Other - 49

Total 4,496 3,879

10. Cash and cash equivalents

Imprest accounts 1 1

Cash at bank 7,140 2,615

Term deposits 105,312 78,032

Total 112,453 80,648

11. Receivables

Trade Debtors 4,220 3,634

4,220 3,634

GST receivable 1,226 586

GST payable (159) (230)

1,067 356

Long service leave reimbursements 91 210

NHMRC Infrastructure Funding 2,274 2,491

Other 2,836 1,655 Total 10,488 8,346

* Total external audit fees relating to the 2010-11 financial year are estimated to be $60,000 (2010: $52,000).There are no non audit services included in this amount.

Heritage assets include research library monographs, Australiana and scarce items that were independentlyvalued at $0.28 million. The service potential of these assets are not expected to diminish with time or use andtherefore, they are not depreciated.



2011 2010

$'000 $'000

12. Inventories

Supplies and consumables - at cost 277 269 Total 277 269

All inventories on hand at 30 June are expected to be realised before 12 months.

13. Other financial assets

Other financial assets at fair value through profit or loss:

Managed fund investments 59,816 13,985

Shares - US listed entities 47 46 Total 59,863 14,031

14. Intangible assets

Software purchased:

At cost 679 590

Less: Accumulated amortisation (110) (42)

569 548

Software internally generated:

At cost 172 133

Less: Accumulated amortisation (19) (2)

153 131

Software WIP

At cost - 107

- 107

Total 722 786

During the 2011 reporting period, $1.065 million of inventories (2010: $1.219 million) were expensed.

QIMR holds shares in Sequenom Inc. which were acquired as a result of the takeover of Gemini pic, in whichthe shares owned by QIMR were originally held. These shares are quoted on the NASDAQ exchange in theUnited States of America and are recorded at their market value at reporting date.


Page 91

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The Council of The Queensland Institute of Medical Research Notes to and forming part of the financial statements 2010-11

2011 2010

$'000 $'000

15. Property, plant and equipment

Buildings:

At fair value 118,641 120,900

Less: Accumulated depreciation (40,856) (39,262)

77,785 81,638

Heritage and cultural assets:

At fair value 283 283

283 283

Plant and equipment:

At cost 52,401 47,353

Less: Accumulated depreciation (28,441) (25,837)

23,960 21,516

Work in progress:

At cost 104,259 29,385

104,259 29,385

Total 206,287 132,822

An interim revaluation of buildings was performed as at 30 June 2011 by indexation using the implicit price deflator. Theexternal registered valuer believed this was the most appropriate index given the number of laboratories containedwithin these buildings. A revaluation index of -1.9% was applied as at 30 June 2011 (2010: -5.6%).The buildingrevaluation for 2010-11 resulted in a decrement of $1.480 million (2010:$5.290 million).

Heritage and cultural assets consisting of research library monographs, Australiana and scarce items have beenincluded at current replacement cost as assessed by an Approved Commonwealth Valuer (Books) Christine M. Tilley,MA QU, MA Adel, Dip ContEd UNE, GradDipLibSc QIT as at 5 September 2006. Management believe this valuation ofperiodicals to be applicable at 30 June 2011 as there is minimal market movement in the value of these rare documents.

Buildings were last revalued as at 30 June 2008 by independent valuer Davis Langdon Australia Pty Ltd. Suchvaluations were based on calculation of the depreciable replacement cost as at 30 June 2008. The values for theseasset classes have since been indexed annually to ensure the value materially reflect fair value as at each reportingdate.


Page 93

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lnotes to and forming part of the financial statements 2010–11the council of the Queensland institute of medical research


2011 2010

$'000 $'000

16. Payables

Trade creditors 10,792 7,358

Others 12 23Total 10,804 7,381

17. Accrued employee benefits

Current

Wages outstanding ^ - 302

Long service leave levy payable 176 139

Annual leave entitlements payable 2,488 2,339

Other 440 433 Total 3,104 3,213

Non-Current

Annual leave entitlements payable 870 763 Total 870 763

18. Unearned revenue

Unearned revenue 87,243 74,406 87,243 74,406

As at 30 June 2011 ($'000) Grants Brought Forward 1 July 2010

Grants Received to date

Grant Expenditure

Grant Carried Forward to next period

Smart State Medical Research Centre 57,511 84,132 75,093 66,550

National Health & Medical Research Council 7,959 25,313 23,126 10,146

Queensland Health - 13,969 13,969 -

QIMR Trust - 1,160 1,160 -

Cancer Australia 1,222 819 749 1,292

Cancer Council Qld 415 1,447 1,616 246

National Institute of Health 647 2,310 2,879 78

Other granting bodies 6,089 13,894 11,895 8,088

Other Commercial Funding Bodies 563 830 550 843 74,406 143,874 131,037 87,243

^ Wages outstanding in 2009-10 financial year relates to Enterprise Bargaining Agreement relating to accrued back pay.


Page 95

18. Unearned Revenue (cont'd)

2011

As at 30 June 2010 ($'000) Grants Brought Forward 1 July 2009

Grants Received to date

Grant Expenditure

Grant Carried Forward to next period

Smart State Medical Research Centre 62,471 14,177 19,137 57,511

National Health & Medical Research Council 5,779 26,462 24,282 7,959

Queensland Health - 6,169 6,169 -

QIMR Trust - 4,417 4,417 -

Cancer Australia 1,586 73 437 1,222

Cancer Council Qld 177 1,894 1,656 415

National Institutes of Health 1,460 4,772 5,585 647

University of Queensland 1,251 (335) (17) 933

Other Granting Bodies 6,042 10,570 11,456 5,156

Other Commercial Funding Bodies 1,101 836 1,374 563 79,867 69,035 74,496 74,406

19. Asset revaluation surplus by class

Buildings Heritage &

cultural assets Total

$'000 $'000 $'000

Balance 1 July 2009 45,714 183 45,897

Revaluation increments/decrements (5,290) - (5,290) Balance 30 June 2010 40,424 183 40,607

Buildings Heritage &

cultural assets Total

$'000 $'000 $'000

Balance 1 July 2010 40,424 183 40,607

Revaluation increments/decrements (1,480) - (1,480) Balance 30 June 2011 38,944 183 39,127



20.

2011 2010

$'000 $'000

Operating surplus/(deficit) 137,867 19,977

Depreciation and amortisation expense 5,412 5,272

Loss on sale of property, plant and equipment 59 -

Gain on sale of property, plant and equipment - (4)

Net increase in other financial asset (2,363) (1,464)

Transfer of gain and financial assets from QIMR Trust (54,766) -

Change in assets and liabilities:

(Increase)/decrease in trade receivables (585) 1,188

(Increase)/decrease in GST input tax credits receivable (640) (178)

(Increase)/decrease in long service leave reimbursement receivables 119 (170)

(Increase)/decrease in NHMRC Infrastructure Funding 217 (3,700)

(Increase)/decrease in other receivables (206) (69)

(Increase)/decrease in inventories (8) 21

(Increase)/decrease in prepayments 353 206

Increase/(decrease) in accounts payable (465) (496)

Increase/(decrease) in accrued employee benefits (3) 325

Increase/(decrease) in unearned revenue 12,837 (5,461)

Increase/(decrease) in GST payable (71) (223)

(Increase) / decrease in investments accounted for using equity method 189 130

Net cash from operating activities 97,946 15,354

21. Non-cash financing and investing activities

22. Commitments for expenditure

(a) Non-Cancellable Operating Lease

Payable:

Not later than one year 48 46

Later than one year and not later than five years 36 84

Later than five years - - Total 84 130

Reconciliation of operating surplus to net cash from operating activities

Assets and liabilities received or donated/transferred by the council and recognised as revenues and expenses areincluded in balances contained in Notes 4 and 15 respectively.

Commitments under operating leases at reporting date are inclusive of anticipated GST and are payable as follows:


Page 97

22. Commitments for expenditure (cont'd)

(b) Capital Expenditure Commitments

2011 2010

$'000 $'000

Payable:

Not later than one year 1,255 1,589

Later than one year and not later than five years - -

Later than five years - - Total 1,255 1,589

Payable:

Not later than one year 1,253 1,074

Later than one year and not later than five years - -

Later than five years - - Total 1,253 1,074

23. Contingencies

Contingent assets

Contributions to Queensland Community Foundation

Contingent liabilities

Other expenditure committed at the end of the period but not recognised in the accounts are as follows:

The abolished QIMR Trust established a fund with the Queensland Community Foundation (QCF) for the purpose ofcreating a specific fund to generate future income and donations. This fund was transferred to Council upon abolition ofthe Trust on the 1 February 2011. All contributions made to this named fund within QCF are held in trust and invested inperpetuity with net income distributed to the Council at the discretion of the Trustee in accordance with the QueenslandCommunity Fund Declaration of Trust. The available balance of this fund was $ 0.358 million at 30 June 2011 (2010:$0.354 million) of which $10,000 was contributed by the former QIMR Trust. The Council expects that earnings from the2010/11 financial year will be brought to account during the financial year ending 30 June 2012.

There were no known contingent liabilities at 30 June 2011.

Operating lease have renewal options however, no leases have escalation clauses other than in the event of paymentdefault.

No lease arrangements create restrictions on other financing transactions.

No other material expenditure items were committed by the Council as at the end of the reporting period.

Material classes of capital expenditure commitments inclusive of anticipated GST, contracted for at reporting date butnot recognised in the accounts are payable as follows:



24. Jointly controlled entities

a) Q-Pharm Pty Ltd

Q-Pharm Pty Ltd 2011 2010$'000 $'000

Income 5,129 5,538

Expenses (5,900) (6,067)Net Surplus/(Deficit) (771) (529)

Current Assets 1,994 2,380

Non Current Assets 369 359

Current Liabilities (1,132) (739)

Non Current Liabilities - - Net Assets 1,231 2,000

b) Vaccine Solutions Pty Ltd

25. Trust transactions and balances

a)

b) Trust for the CRC for Vaccine Technology (CRCVT Trust II)

QIMR accounts for its 24.5% interest in Q-Pharm Pty Limited on an equity accounted basis..

Q-Pharm did not have any material contingent liabilities or commitments as at 30 June 2011. Council has notindividually or jointly incurred any contingent liabilities in Q-Pharm. Council is not contingently liable for the liabilities ofthe other ventures of Q-Pharm.

QIMR and CSL Limited are equal shareholders in Vaccine Solutions Pty Ltd, a company established in 1998 to provideClinical Trial Sponsorship, intellectual property management and commercialisation services to the CRC for VaccineTechnology (CTC-VT). Upon the winding up of the CRC-VT the company manages a number of licensing arrangementsfor the benefit of the members of CRC-VT Trust II. Vaccine Solutions does not own any physical or intellectual propertyassets of its own and is required to return 97% of all commercial income received from licensing activities to the CRC-VT Trust II for distribution to members of that trust.

Q-Pharm Pty Limited is a Phase 1 Clinical Trial company. The company is a joint venture between Professors Hooperand Dickinson, QIMR and The University of Queensland. QIMR holds 24.5% of the shares of Q-Pharm Pty Limited[2009/10: 24.5%].

A summary of the financial transactions and balances for Q-Pharm Pty Limited is as follows:

QIMR is the Trustee of the CRC for Vaccine Technology (CRC-VT) Trust [CRCVT Trust II], a trust responsible for managing patent families and licensing arrangements on behalf of the participants in the CRC for Vaccine Technology since winding up in June 2006, Income received from licensing arrangements is distributed to the members in the trust according to their participating share in the CRC-VT as of June 2006. The members of the trust are: The Queensland Institute of Medical Research, CSIRO, CSL Limited, The University of Melbourne, Walter and Eliza Hall Institute of Medical Research, Monash University, Australian Red Cross Blood Service and La Trobe University.

As the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inthe financial statements but are disclosed in these notes for the information of users.

Trust for the CRC for Vaccine Technology (CRCVT Trust I)

QIMR is the Trustee of the CRC for Vaccine Technology Trust [CRCVT Trust I], a trust managing shares in VacTx Pty Ltd on behalf of the participants of the CRC-VT. VacTx Pty Ltd is a company focused on the development of vaccines through intellectual property created by the CRC-VT. The CRC-VT wound up operations in June 2006. Income received from the sale of the shares is to be distributed to the members in the trust according to their participating share in the CRC-VT as of June 2006. The members of this trust are: The Queensland Institute of Medical Research, CSIRO, The University of Melbourne, Walter and Eliza Hall Institute of Medical Research, Monash University, Australian Red Cross Blood Service and La Trobe University.


As the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inAs the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inAs the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inAs the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inthe financial statements but are disclosed in these notes for the information of users. As the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inthe financial statements but are disclosed in these notes for the information of users. As the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inAs the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inAs the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inthe financial statements but are disclosed in these notes for the information of users. As the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inthe financial statements but are disclosed in these notes for the information of users. As the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inAs the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inAs the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inthe financial statements but are disclosed in these notes for the information of users.

Page 99

25. Trust transactions and balances (cont'd)

Trust for the CRC for Vaccine Technology (CRCVT Trust II) 2011 2010$'000 $'000

Trust Revenues and Expenses

Income 272 584

Expenses (275) (576)Net Surplus/(Deficit) (3) 8

Trust Assets and Liabilities

Current AssetsCash 45 133

Receivables 572 411

Total Assets 617 544

Current LiabilitiesPayables 4 14

Provision for income tax 6 6

Beneficiaries entitlements payable 602 517

Total Liabilities 612 537

Total Trust Net Assets 5 7

c) Employee Research Services

Employee Research Services

Trust Revenues and Expenses

Income 925 882

Expenses (931) (475)Increase / (Decrease) in net employee research services (6) 407

Trust Assets

Current AssetsCash held in short term deposits 2,332 2,338Total Trust Assets 2,332 2,338

26. Key executive management personnel and remuneration

a) Key Executive Management Personnel

The Institute undertakes a custodial role in respect of transactions and balances relating to employee research servicesand they are therefore not recognised in the financial statements.

As the Council performs only a custodial role in respect of these transactions and balances, they are not recognised inthe financial statements but are disclosed in these notes for the information of users.

The following details for key executive management personnel include those positions that had authority andresponsibility for planning, directing and controlling the activities of the agency during 2010-11. Further information onthese positions can be found in the body of the Annual Report under the section relating to Executive Management.



26. Key executive management personnel and remuneration (cont'd)

b) Remuneration

1 July 2010 - 30 June 2011

Long Term Employee Benefits

Post Employment

benefits

Termination Benefits

410 27 8 25 -

1 July 2009 - 30 June 2010

Long Term Employee Benefits

Post Employment

benefits

Termination Benefits

293 25 6 37 -

470

Remuneration packages for key executive management personnel comprise the following components:-

i) Short term employee benefits which include:o Base - consisting of base salary, allowances and leave entitlements paid and provided for the entire year or for thatpart of the year during which the employee occupied the specified position. Amounts disclosed equal the amountexpensed in the Statement of Comprehensive Income.o Non-monetary benefits – consisting of provision of vehicle together with fringe benefits tax applicable to the benefit.

ii) Long term employee benefits include long service leave accrued.

iii) Post employment benefits include superannuation contributions.

iv) Redundancy payments are not provided for within individual contracts of employment. Contracts of employmentprovide only for notice periods or payment in lieu of notice on termination, regardless of the reason for termination.

v) There are no performance bonuses payable to key executive management.

Total fixed remuneration is calculated on a ‘total cost’ basis and includes the base and non-monetary benefits, longterm employee benefits and post employment benefits:

Position

Short Term Employee Benefits

Total Remuneration

Remuneration policy for the agency’s key executive management personnel is set by Council as provided for under theQueensland Institute of Medical Research Act 1945 . The remuneration and other terms of employment for the keyexecutive management personnel are specified in employment contracts. The contracts provide for the provision ofother benefits including motor vehicles.

Director is responsible for efficient and effective administration of the Institute

Appointed by Governor in Council, s10 QIMR Act 1945

4 January 2011

Position ResponsibilitiesCurrent Incumbent

Contract classification and appointment authority

Date appointed to position

Director

Director / Acting Directors

Director 361

Base$'000

Non-monetary Benefits

$'000

$'000 $'000 $'000 $'000

Position

Short Term Employee Benefits

Total Remuneration

Base$'000

Non-monetary Benefits

$'000

$'000 $'000 $'000 $'000


Page 101

27.

2011 2010$'000 $'000

Current Assets

Cash and cash equivalents 651 1,067

Trade and other receivables 314 608

Other current assets 36 -

Total Current Assets 1,001 1,675

Non Current Assets

Other financial assets 54,115 50,029

Total Non Current Assets 54,115 50,029

Total Assets 55,116 51,704

Current Liabilities

Payables 131 246

Total Current Liabilities 131 246

Total Liabilities 131 246

Net Assets 54,985 51,458

28. Financial Instruments

(a) Categorisation of Financial Instruments

The Council has the following categories of financial assets and financial liabilities:

Category Note

Financial Assets



Other financial assets 13 59,863 14,031 182,804 103,025

Financial Liabilities

Financial liabilities measured at amortised cost:

Payables 16 (10,804) (7,381) Total (10,804) (7,381)

Transfer of the assets and liabilities of the abolished QIMR Trust to the Council of the Queensland Instituteof Medical Research

The Queensland Institute of Medical Research Trust was abolished with effect on the 1 February 2011. On the Trustabolition day the net assets of the Trust immediately before the Trust abolition day became the assets and liabilities ofthe Council, as prescribed by the Water and Other Legislation Amendment Act 2010 . The 2010 balances have beenreported below for comparative purposes only. The book values of the assets and liabilities transferred to the Council,as at 31 January 2011, were recorded in the abolished Trust as follows:



28. Financial Instruments (cont'd)

(b) Financial Risk Management

(c) Credit Risk Exposure

2011 2010

Note $'000 $'000

Financial Assets



Other financial assets 13 59,863 14,031Total 182,804 103,025

No collateral is held as security and no credit enhancements relate to financial assets held by the Council.

The Council manages credit risk through the use of a credit management strategy. This strategy aims to reduce theexposure to credit default by ensuring that the Council invests in secure assets and monitors all funds owed on a timelybasis. Exposure to credit risk is monitored on an ongoing basis.

No financial assets and financial liabilities have been offset and presented net in the Statement of Financial Position.

The method for calculating any provision for impairment is based on past experience, current and expected changes ineconomic conditions and changes in client credit ratings. These economic and geographic changes form part of thecouncil's documented risk analysis assessment in conjunction with historic experience and associated industry data.This analysis has identified that that none of the Trust's financial assets are impaired and subsequently provisions forimpairment have not been raised.

No financial assets have had their terms renegotiated so as to prevent them from being past due or impaired, and arestated at the carrying amounts as indicated.

Ageing of past due but not impaired financial assets are disclosed in the following tables. No financial assets wereassessed as being impaired as at 30 June 2011:

The following table represents the Council's maximum exposure to credit risk based on contractual amounts net of anyallowances:

Market risk interest rate sensitivity analysis

The Council's activities expose it to a variety of financial risks - interest rate risk, credit risk, liquidity risk and market risk.

All financial risk is managed by the Queensland Institute of Medical Research Corporate Services Division underpolicies approved by the Council. The Council provides written principles for overall risk management, as well aspolicies covering specific areas.

Financial risk management is implemented pursuant to Government and Council policy. These policies focus on theunpredictability of financial markets and seek to minimise potential adverse effects on the financial performance of theCouncil.

The Council measures risk exposure using a variety of methods as follows -

Risk Exposure Measurement method

Credit risk Ageing analysis, earnings at risk

Liquidity risk Sensitivity analysis

Credit risk exposure refers to the situation where the Council may incur financial loss as a result of another party to afinancial instrument failing to discharge their obligation.

The maximum exposure to credit risk at balance date in relation to each class of recognised financial assets is thegross carrying amount of those assets inclusive of any provisions for impairment.


Page 103


2011 Financial Assets Past Due But Not Impaired

NoteLess than 30

Days 30- 60 Days

More than 90 Days Total

$'000 $'000 $'000 $'000

Receivables 11 9,448 657 7 376 10,488 Total 9,448 657 7 376 10,488

2010 Financial Assets Past Due But Not Impaired

NoteLess than 30

Days 30- 60 Days

More than 90 Days Total

$'000 $'000 $'000 $'000

Receivables 11 6,272 749 279 1,046 8,346 Total 6,272 749 279 1,046 8,346

(d) Liquidity Risk

Total

Note >5 year

$'000 $'000


Payables 16 (10,804)

Total (10,804)

Total

Note >5 year

$'000 $'000


Payables 16 (7,381)Total (7,381)

(7,381) -(7,381) -

--

$'000 $'000

<1 year 1-5 years

$'000 $'000

(10,804) -

-

-

(10,804)

Liquidity risk refers to the situation where the Council may encounter difficulty in meeting obligations associated withfinancial liabilities that are settled by delivering cash or another financial asset.

The Council is exposed to liquidity risk in respect of its payables.

The Council manages liquidity risk through the use of a liquidity management strategy. This strategy aims to reduce theexposure to liquidity risk by ensuring the Council has sufficient funds available to meet employee and supplierobligations as they fall due. This is achieved by ensuring that minimum levels of cash are held within the various bankaccounts so as to match the expected duration of the various employee and supplier liabilities.

The following table sets out the liquidity risk of financial liabilities held by the Council. It represents the contractualmaturity of financial liabilities, calculated based on undiscounted cash flows relating to the liabilities at reporting date.The undiscounted cash flows in these tables may differ from the amounts included in the Statement of Financial Positionthat are based on discounted cash flows.

2011 Payable in

-

2010 Payable in

<1 year 1-5 years

$'000

Overdue

61-90 Days

$'000

Overdue

61-90 Days




(e) Market Risk

(f) Interest Rate Sensitivity Analysis

Profit $'000 Equity $'000 Profit $'000

(1,125) (1,125) 1,125(1,125) (1,125) 1,125


(806) (806) 806(806) (806) 806

Other Price Risk Sensitivity Analysis


(599) (599) 599

(599) (599) 599


(140) (140) 140

(140) (140) 140

Managed Funds & Listed Shares

14,031 140

140

Financial Instruments Carrying Amount

2010 Other Price Rate Risk

-1% +1%

$'000 Equity $'000

Potential Impact

$'000 Equity $'000Managed Funds & Listed Shares

59,863 599

599

The following other price risk sensitivity analysis is based on a report similar to that provided to management, depicting the outcome on profit or loss if unit/share price would change by +/-1% from the year-end price applicable to the Council's other financial asset investments. With all other variables held constant, the Council would have a surplus and equity increase/(decrease) of $599k (2010: $140k). This is mainly attributable to exposure to unit price movements in its investments managed funds and movements in market value of US listed shares.


2011 Other Price Rate Risk

-1% +1%

Potential Impact

Cash & cash equivalents 80,648 806806

Cash & cash equivalents 112,453 1,1251,125


2010 Interest Rate Risk

-1% +1%

Potential Impact

Potential Impact

$'000 Equity $'000

The Council does not trade in foreign currency and is not materially exposed to movements in foreign currencyexchange rates, although it does hold some residual funds in Hong Kong. The Council does not undertake any hedgingin relation to interest risk and manages its risk as per the Council's liquidity risk management strategy articulated in theCouncil's policies. The Council is exposed to movements in interest rate risk through its investment in externally

The following interest rate sensitivity analysis is based on a report similar to that provided to management, depicting theoutcome on net income if interest rates would change by +/- 1% from the year-end rates applicable to the Council'sfinancial assets and liabilities. With all other variables held constant, the Council would have a surplus and equityincrease/(decrease) of $1,125million (2010: $806k). This is mainly attributable to the Council's exposure to interest ratemovements in its holdings in cash and cash equivalents.

$'000 Equity $'000


2011 Interest Rate Risk

-1% +1%


Page 105


(g) Fair Value

29. Events Occurring After Balance Date

30. Changes in Accounting Estimates and Correction of Errors

Financial Statement comparative figures have been restated to correct inaccurate revenue estimates in the financial years 2004-05 to 2009-10 related to estimates of funding receivable through the NHMRC Infrastructure Support (IRIIS). The cumulative effect of the error resulted in an overstatement of Receivables, and an overstatement of Accumulated Surplus at June 2010 of $1,209k. The error has been corrected by restating each affected financial statement line items for the prior year.

The fair value of trade receivables and payables is assumed to approximate the value of the original transaction, less any provision for impairment.

Managed fund investments

13,985 - - 13,985

Total 14,031 - - 14,031

$'000

Financial Assets

Class

Financial Assets

Level 3

Managed fund investments 59,816 - - 59,816

$'000 $'000 $'000

US listed entities 47 - - 47

Total 59,863 - - 59,863

Carrying Amount

Level 1 Level 2

2010 Classification according to fair value hierarchy

Level 1 - fair values that reflect unadjusted quoted prices in active markets for identical assets/liabilities;Level 2 - fair values that are based on inputs that are directly or indirectly observable for the asset/liability (other than unadjusted quoted prices); and

Level 3 - fair values that are derived from data not observable in a market.

According to the above hierarchy, the fair values of each class of asset/liabilities recognised at fair value are as follows:

Class

2011 Classification according to fair value hierarchy Carrying Amount

Level 1 Level 2 Level 3

$'000 $'000 $'000 $'000

The recognised fair values of financial assets and liabilities are classified according to the following fair value hierarchythat reflects the significance of the inputs used in making these measurements:

Funding for the Smart State Medical Research Centre (SSMRC) is recognised as revenue in the financial statements in the period in which the Institute gains control of the funds. Since the commencement of the SSMRC project, revenue has been recognised in the financial statements as Capital Grants. Revenue recognised as Capital Grants includes amounts earned on investment of grant funds received. Financial Statement comparative figures have been restated to reflect the amount of interest earned on Capital Grant funds in the 2009-10 financial year. A reclassification of the revenue in the Statement of Comprehensive Income has resulted in a decrease to the line item Grants and other contributions and an increase to Other Revenue by $4,288k.

There are no events occurring after balance date having a material impact on the figures reported in the above statements.

US listed entities 46 - - 46



the council of the Queensland institute of medical research

certificate of the council of the Queensland institute of medical research

These general purpose financial statements have been prepared pursuant to section 62(1) of the Financial Accountability Act 2009 (the Act), relevant sections of the Financial and Performance Management Standard 2009 and other prescribed requirements. In accordance with section 62(1)(b) of the Act we certify that in our opinion:

a) the prescribed requirements for establishing and keeping the accounts have been complied with in all material respects; and

b) the statements have been drawn up to present a true and fair view, in accordance with prescribed accounting standards, of the transactions of the Council of the Queensland Institute of Medical Research for the financial year ended 30 June 2011 and of the financial position of the Council at the end of that year.

Dated at Brisbane this 2nd day of September 2011

Professor John Hay AC Professor Frank Gannon Donna Hancock Chairman of Council Director & Chief Executive Officer Secretary

Dated at Brisbane this 2nd day of September 2011

Professor John Hay AC Professor Frank Gannon Donna HancockChairman of Council Director & Chief Executive Officer Secretary

Page 107

independent auditor’s reportthe council of the Queensland institute of medical research


SuppoRtInG InFoRmAtIon


aWarDSRecipient

Bestower of award

Date Award Reason

Kylie Alexander ASMR May-11 ASMR Premier's Award 1st place - oral presentation. Best research by postgraduate researcher

Prof Greg Anderson International BioIron Society

May-11 President Elect of the Society Voted by the membership to be the next President of IBIS

Dr Simon Apte ASI Aug-10 Travel award (international) Conference attendance

Dr Simon Apte ASI Jan-11 Appointment ASI Newsletter Editor

Assoc Prof Michael Breakspear

ASMR Jun-11 Clinical Researcher Award

Enda Byrne Australasian Society of Psychiatric Research

Young Investigator Travel Award Conference attendance

Fernanda Cardoso ASI Aug-10 Travel award (international) Conference attendance

Prof Denise Doolan Australia - Europe Malaria Research Cooperation

Feb-10 Appointment Scientific Advisory Board

Prof Denise Doolan Australian Society for Parasitology

Aug-10 Appointment President-Elect

Blake Ferguson Nov-10 1st prize poster competition, 7th Annual International Melanoma Congress

Dr Katja Fischer QIMR May-11 QIMR Postgraduate Travel Award 2011

Conference attendance

Dr Darren Gray GU Dec-10 Publication of the Year Best paper in Public Health at GU

Prof Geoff Hill NHMRC Mar-11 Australia Fellowship

Prof Geoff Hill OHMR Jun-11 Senior Clinical Research Fellowship

Prof Geoff Hill NHMRC Mar-11 Practitioner Fellowship (level 2)

Assoc Prof Malcolm Jones

Australian Society for Parasitology

Aug-10 Fellow of the Australian Society for Parasitology

Contributions to Australian Parasitology

Dr Motoko Koyama TSANZ Jun-11 Young Investigator Award Quality of research by young investigator

Dr Motoko Koyama ASI Dec-10 Travel award Conference attendance

Dr Felicity Lose PCFA Aug-10 Travel award

Dr Felicity Lose Contributing to Australian Scholarship and Science Foundation

Apr-11 Travel award

Dr Felicity Lose CCQ May-11 Travel award

Dr Kelli MacDonald CCQ Jan-11 Senior Research Fellowship

Dr Cameron McDonald ALF Jan-11 ALF Hospitality Industry Career Development Research Fellowship

Prof Don McManus NHMRC Dec-10 Senior Principal Research Fellowship

NHMRC RF Scheme

Prof Don McManus Veterinarni Medicina

Jan-11 Invited Editorial Board Member

Prof Don McManus American Society of Tropical Medicine and Hygiene

Nov-10 Honorary membership of the American Society of Tropical Medicine and Hygiene

In recognition of outstanding accomplishment by an individual not an American citizen who has made eminent contributions to some phase of tropical medicine and hygiene.

Dr Sarah Medland Australian Institute of Policy and Science

Nov-10 Young Tall Poppy Science Award Early career researcher award for scientific milestones and demonstrative ability to engage people in science

Dr Sarah Medland Behavior Genetics Association

Jun-11 Fuller and Scott Award Outstanding young investigator who has made substantial contributions to the field of Behavior Genetics

Dr Sarah Medland Behavior Genetics Association

Jun-11 Fulker Award Best paper published in the journal Behavior Genetics in 2010

Dr Sarah Medland QIMR Jun-11 QIMR Travel Award Conference attendance

Dr Catherine Olsen QIMR Nov-10 QIMR Overseas Conference Support

1st International Conference on UV and Skin Cancer Prevention

Renee Robb TSANZ Jun-11 President’s prize Best research at annual meeting

Dr David Reid OHMR Feb-11 Clinical FellowshipFeb-11 Clinical FellowshipFeb-11 Clinical Fellowship

Page 111

RecipientBestower of award

Date Award Reason

Haran Sivakumaran MSD Schering-Plough Pty Ltd

Jun-11 Top Post-Doc Award (HIV) Outstanding scientific presentation

Dr Patricia Valery NHMRC Dec-10 Excellence award Highest ranked Career Development Award application

Prof Emma Whitelaw ANZSCDB Sep-10 President's Medal Outstanding contribution to cell and developmental biology

Prof Emma Whitelaw International Union of Biochemists and Molecular Biologists

Feb-11 IUBMB Jubilee Lecture and Medal Contribution to the understanding of transcription and epigenetic inheritance

Dr Susan Woods ASMR Jun-11 2011 Queensland Senior Researcher Award

Dr Daniel Worthley NHMRC Jun-10 RG Menzies Fellowship Most outstanding recipient of CJ Martin Postdoctoral Fellowship

Dr Neil Youngson Lalor Foundation Apr-11 Travel Award Conference attendance

LegendANZSCDB Australia and New Zealand Society for Cell and Developmental Biology

ASI Australasian Society of Immunology

ASMR Australian Society of Medical Research

CCQ Cancer Council Queensland

GU Griffith University

NHMRC National Health and Medical Research Council

OHMR Office of Health and Medical Research

PCRFA Prostate Cancer Research Foundation Australia

TSANZ The Transplantation Society of Australia and New Zealand

inViteD LectureSSpeaker Title of lecture Date Audience or event City, Country

Prof Greg Anderson Iron absorption and its regulation in the perinatal period

Jul-10 Biometals 2010. Seventh International Biometals Symposium

Tucson, USA

Prof Greg Anderson Iron metabolism. Nov-10 Metabolism and Cancer Symposium. School of Biomedical Sciences, The University of Queensland

Brisbane, Australia

Prof Greg Anderson Iron metabolism and testing Mar-11 RCPA: Pathology Update 2011 Melbourne, Australia

Prof Greg Anderson Essential but toxic: Controlling the flux of iron in the body

Apr-11 Third Australia-China Biomedical Research Conference

Melbourne, Australia

Prof Greg Anderson Invited Session Chair - Iron signalling pathways

May-11 Bioiron 2011. World Congress on Iron Metabolism.

Vancouver, Canada

Kylie Alexander Speaker May-11 The ASMR Medical Research Week Student Conference

Brisbane, Australia

Dr Ann Apolloni A New, Potent Transdominant Negative Tat Blocks HIV-1 Replication

Jun-11 Australian Centre for HIV and Hepatitis Research 7th Annual Workshop

Sunshine Coast, Australia

Dr Simon Apte The role of PD-1 in malaria Nov-10 Emory Vaccine Research Centre Atlanta, USA

Dr Kathy Andrews Transcriptional profiling the effects of hydroxamate-based HDAC inhibitors in P. falciparum

Aug-10 International Congress of Parasitology XII


Dr Kathy Andrews Transcriptional profiling the effects of hydroxamate-based HDAC inhibitors in P. falciparum

Nov-10 Australian Health and Medical Research Congress


Dr Barrie Anthony Schistosoma mansoni egg-induced downregulation of hepatic stellate cell activation and fibrogenesis

Oct-10 Australian Gastroenterology Week 2010 meetIng

Gold Coast, Australia

Dr Annika Antonsson Viruses in breast cancer May-11 National Breast Cancer Foundation Sydney, Australia

Dr Vanessa Beesley Current and planned cancer survivorship research at QIMR

Nov-10 Clinical Oncology Society of Australia Annual Scientific Meeting - Cancer Survivorship Workshop

Melbourne, AustraliaAnnual Scientific Meeting - Cancer Survivorship Workshop


Speaker Title of lecture Date Audience or event City, Country

Dr Vanessa Beesley Pancreatic cancer patients’ supportive care needs and corresponding use of allied health services

Nov-10 Psycho-Oncology Co-operative Research Group (PoCoG) Professional Day


Gabriëlla Blokland Genetic influences on white matter tract density within the working memory network

May-11 2011 Australian Society for Medical Research Postgraduate Student Conference

Brisbane, Australia

Prof Andrew Boyd Recent advances in brain tumour research: Prospects for therapy

May-11 Cancer Council Queensland Brain Tumour Symposium

Brisbane, Australia

Dr Glen Boyle Local cure of melanoma in mice and dogs by intratumoral injection of EBC46

Nov-10 Society for Melanoma Research 2010 Congress

Sydney, Australia


Predictive coding Nov-10 Monash University neuroscience workshop



Brain modelling Jan-11 University of Queensland Summer School

Brisbane, Australia


Neonatal burst suppresion Jun-11 Brain Connectivity Workshop Montreal, Canada


Multistable brain rhythms Jun-11 Yale Seminar Series New Haven, USA


Multistable brain rhythms Jun-11 Human Brain Mapping Quebec, Canada


Brain Modelling Jun-11 Human Brain Mapping Quebec, Canada


Scale-free brain dynamics Nov-10 Computational neuroscience summer school

Brisbane, Australia


Brain connectivity: A primer Dec-10 Australian Society for Psychiatric Research

Sydney, Australia

Assoc Prof Scott Burrows

Allelic polymorphism in the T cell receptor – assessing its overall importance

Jul-10 Structural Immunology Meeting, Monash University



The sensitivity of peptide-MHC-TCR binding

Nov-10 Emory Vaccine Centre Atlanta, USA


T cell immune response to Epstein-Barr virus

Nov-10 Australian Society for Microbiology WA branch dinner

Perth, Australia


The T cell immune response to Epstein-Barr virus

Nov-10 Institute for Immunology and Infectious Diseases, Murdoch University

Perth, Australia


New insights into alloreactivity Nov-10 Australian Society for Immunology (WA Branch) monthly meeting

Perth, Australia


The T cell immune response to Epstein-Barr virus

May-11 Centenary Institute Sydney, Australia

Dr Fernanda Cardoso Development of a high throughput approach to identify the targets of cellular immunity on a proteome-wide scale

Aug-10 International Congress of Immunology Kobe, Japan

Dr Fernanda Cardoso Proteome-wide screening of complex pathogen to identify antigens targets by T cell mediated immune responses

Aug-10 International Congress of Parasitology Melbourne, Australia

Prof Georgia Chenevix-Trench

Genome wide association studies: are we there yet?

Jun-10 Children’s Medical Research Institute Sydney, Australia


Genome wide association studies: are we there yet?

Nov-10 Human Genetics Society of Australasia Annual Scientific Conference



A guide for PhD students Apr-11 Student Retreat, UQ Diamantina Institute

Brisbane Australia


Genome wide association studies: the role of biobanks

Dec-11 8th Annual Australasian Biospecimen Network Meeting

Brisbane Australia


Towards personalised therapy for ovarian cancer

Feb-11 The Charles Rodolphe Brupbacher Foundation

Zurich, Switzerland

Dr Qin Cheng A large proportion of asymptomatic malaria infections with low parasite densities in Temotu province, Solomon Islands: challenges for malaria diagnostics in an elimination setting.

Nov-10 The 59th ASTMH annual meeting Atlanta, USA

Dr Qin Cheng Genotying P. vivax May-11 APMEN vivax Working Group Genotyping Workshop

Kota Kinabalu, Malaysia

Dr Qin Cheng Facts and challenges: knowledge gaps in malaria diagnosis for elimination

May-11 APMEN vivax Working Group Genotyping Workshop

Kota Kinabalu, Malaysia

Dr Suyinn Chong Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model

May-10 Queensland Brain Institute Symposium: Epigenomics, Behaviour & Disease

Brisbane, Australia

Dr Suyinn Chong Epigenetics and a mouse model of foetal alcohol syndrome

Oct-10 Annual inservice for Queensland geneticists and genetic counsellors, Royal Brisbane and Women’s Hospital

Brisbane, Australia

Royal Brisbane and Women’s Hospital

Page 113


Dr Suyinn Chong The role of epigenetics in phenotypic variation and disease risk

Mar-11 Children's Medical Research Institute Seminar Series

Sydney, Australia

Dr Suyinn Chong The role of epigenetics in gestational programming of progeny phenotype by maternal ethanol consumption

Sep-10 Endocrine Society of Australia & Society of Reproductive Biology Annual Scientific Meeting

Sydney, Australia

Dr Suyinn Chong Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model

Oct-10 7th India-Australia Biotechnology Conference

Brisbane, Australia

Dr Jon Darbro Assessment of Beauveria bassiana for control of Aedes aegypti: Effects on blood-feeding behaviour, fecundity and virulence in semi-field conditions

Sep-10 Australian Mosqutio Control Association

Caloundra, Australia

Lucia Daxinger Rif1, a novel modifier of epigenetic reprogramming in the mouse

Dec-10 Max-Planck Freiburg Epigenetics Meeting

Freiburg, Germany

Prof Denise Doolan Mining genomic, proteomic and transcriptomic datasets for next generation malaria vaccine development


Prof Denise Doolan Molecular immunology in the genomics era: novel advances for vaccine development.

Dec-10 Australasian Society of Immunology Postgraduate Student Workshop

Perth, Australia

Prof Denise Doolan Proteome-wide screening of P. falciparum CD4 and CD8 T cell epitopes

Dec-10 Australasian Society of Immunology Symposium

Perth, Australia

Prof Denise Doolan Genomes to vaccines: a 21st century solution for complex pathogens

Oct-10 Pfizer Australia Melbourne, Australia

Prof Denise Doolan Malaria – 21st century approaches to combating an ancient enemy

Apr-11 Papua New Guinea Biomedical and Social Sciences Society Symposium.

Papua New Guinea

Prof Denise Doolan Molecular vaccinology Nov-10 Emory Vaccine Research Centre Atlanta, USA

Dr David Duffy Estimating extremely small Monte-Carlo P-values cheaply

Apr-11 8th GeneMappers Conference Hobart, Australia

Ken Dutton-Regester A high throughput mutation screening panel for the identification of clinically relevant profiles in melanoma

Oct-10 TRX10- Translational Research Excellence 2010

Brisbane, Australia

Dr Christian Engwerda Immune regulation during parasitic diseases.

Jul-10 Biology of Parasitism Course Woods Hole, USA


Aug-10 The XIIth International Congress of Parasitology (ICOPA)



Nov-10 Department of Biochemistry, Indian Institute of Chemical Biology

Kolkata, India


Nov-10 Rajendra Memorial Research Institute of Medical Sciences

Patna, India


Nov-10 Institute of Medical Sciences, Banaras Hindu University

Varabasi, India


Dec-10 Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine

London, UK


Dec-10 Use of animal models in malaria research (Wellcome Trust)

Cambridge, UK


Dec-10 Australian Society for Immunology Perth, Australia

Dr Christan Engwerda Immune regulation during parasitic diseases.

Apr-11 Local regulation of infection, inflammation and autoimmunity. SFB 841 Symposium. Bernhard Nocht Institute for Tropical Medicine

Hamburg, Germany

Dr Manuel Ferreira Invited Faculty Mar-11 2011 International Workshop on Statistical Methodology for Human Genomic Studies

Boulder, Colorado

Dr Manuel Ferreira Mapping common and rare risk variants for asthma


Dr Manuel Ferreira Australian Asthma Genetics Consortium Apr-11 2011 TSANZ ASM Perth, Australia

Dr Katja Fischer Scabies mite inactivated protease paralogs inhibit the human complement system

Aug-10 XIIth International Congress of Parasitology (ICOPA)


Dr Katja Fischer Scabies mite complement inhibitors promote streptococcal skin infections, rheumatic fever and heart disease

Mar-11 Heart Foundation Conference 2011 Melbourne, Australia

Assoc Prof Maher Gandhi

'It started with a kiss: I never thought it would end like this'

Apr-11 World Immunology Day Brisbane, Australia


ITP Mar-11 Grand Rounds, Princess Alexandra Hospital

Brisbane, Australia


World Lymphoma Day Sep-11 Leukaemia Foundation Brisbane, Australia

invited lectures | continued


World Lymphoma Day Sep-11 Leukaemia Foundation Brisbane, Australia




EBV-related post-transplantation lymphoproliferative disorders: a haematologists perspective

Jun-11 Transplantation Society of Australasian and New Zealand

Canberra, Australia


A new and highly aggressive lymphoma Aug-11 World Congress of Virology and Immunology

Busan, South Korea


EBV+ DLBCL Sep-11 International Association for Research on Epstein-Barr virus and Associated Diseases

Birmingham, UK

Assoc Prof Don Gardiner

High throughput screening for new anti gametocidal agents

Oct-10 Medicines for Malaria Venture ESCA Meeting

Geneva , Switzerland

Assoc Prof Gail Garvey Understanding dementia in urban, rural and remote Aboriginal and Torres Strait Islander communities in Queensland

Aug-10 Statewide Dementia Clinical Network Forum

Brisbane, Australia

Assoc Prof Gail Garvey Knowledge of dementia in an Indigenous population

Sept-10 Dementia Collaborative Research Centre Forum

Surfers Paradise Queensland

Dr Michelle Gatton Quantifying the sensitivity of malaria transmission to temperature and seasonality: implications for malaria control programs

Aug-10 XIIth International Congress of Parasitology


Dr Michelle Gatton Directions for infectious diseases modelling Jan-11 Research and Policy for Infectious Disease Dynamics (RAPIDD) Annual Convocation

Washington, USA

Dr Michelle Gatton Modelling mosquito adaptation to control May-11 RAPIDD-sponsored workshop of international scientists

London, UK

Dr Michelle Gatton Analysis of WHO Malaria RDT Product Testing (Round 3)

May-11 WHO Product Testing Steering Committee

London, UK

Dr Michelle Gatton Disasters and Diseases Jun-11 ASMR Science in the Pub Brisbane, Australia

Imogen Gillions Development and validation of a murine model for dendritic cell (DC)-based immunotherapy

Dec-10 ASI Tumour Immunology Workshop. ASI Annual Scientific Meeting

Perth, Australia

Priscilla Goh The role of peritrophins in scabies mite innate immunity (poster presentation)



Dr Geoffrey Gobert Schistosome cell and molecular biology Nov-10 Department of Medicine, UNAM Mexico City, Mexico

Dr Geoffrey Gobert Schistosome comparative genomics Nov-10 ASTMH Annual Meeting Atlanta, USA

Prof Jeff Gorman Regulation of Type I Interferon-Dependent and -Independent Antiviral Responses by Respiratory Syncytial Virus Non-Structural Protein 1

Sep-10 HUPO2010 Sydney, Australia

Prof Jeff Gorman Global Proteomic Views of Interferon Responses in Respiratory Syncytial Virus Infected A549 Type II Alvelor Epithelial Cells

Feb-11 Australian Proteomics Society Lorne, Australia

Prof Jeff Gorman Global Proteomic Views of Interferon Responses in Respiratory Syncytial Virus Infected A549 Type II Alevelolar Epithelial Cells

Feb-11 Lorne Infection and Immunity Conference

Lorne, Australia

Dr Darren Gray Schistosomiasis Sep-10 MPH Students, School of Population Health, The University of Queensland

Brisbane, Australia

Prof Adèle Green The role of sunscreen in melanoma prevention

Feb-11 Qld Mining Health Improvement and Awareness Committee

Brisbane, Australia

Prof Adèle Green Current evidence on skin cancer prevention Apr-11 British Society for Investigative Dermatology Annual Conference

Manchester

Prof Adèle Green Childhood exposure to ultra-violet radiation and harmful skin effects: epidemiological evidence

May-11 International Joint Conference on Non-Ionizing Radiation and Children's Health

Ljubljana, Slovenia

Prof Adèle Green Effectiveness of sunscreens in skin cancer prevention

May-11 22nd World Congress of Dermatology Seoul, Korea

Prof Adèle Green Melanomas in the Sunshine State- what's new?

Jun-11 Capacity Building Grant Public Health Leadership Forum


Dr Sarah Harten Epigenetic control of reprogramming May-11 Mater Medical Research Institute Stem Cell Symposium

Brisbane

Prof Nick Hayward A multi-faceted approach to discover new familial melanoma genes

Sept-10 Queenstown Molecular Biology Meeting

Queenstown, New Zealand

Prof Nick Hayward Update on the Aussie melanoma GWAS May-11 International Melanoma Genetics Consortium meeting

Tel Aviv, Israel

Prof Nick Hayward Approaches to discover new melanoma

predisposition genes

Nov-10 Scott Kirkbride Melanoma Research Centre ‘Advances in melanoma’ satellite symposium

Perth, Australia

Prof Nick Hayward An Australian genome-wide association study to identify melanoma predisposition genes

Nov-10 7th International Melanoma Research Sydney, Australia

Prof Geoff Hill Antigen presentation after transplantation: where and when?

Feb-11 American Society of Bone Marrow Transplantation

Hawaii, USAFeb-11 American Society of Bone Marrow Antigen presentation after transplantation: where and when?

Page 115


Prof Geoff Hill IL-17 responses in transplantation Sep-10 Society for Hematology and Stem Cells Melbourne, Australia

Prof Geoff Hill The great debate: doctors make poor scientists

Dec-10 Australasian Society of Immunology Perth, Australia

Prof Geoff Hill Antigen presentation in transplantation Jun-11 Centenary Institute Sydney, Australia

Prof Geoff Hill Transplantation, from bench to bedside May-11 Amgen Haematology and Oncology scientific meeting

Sydney, Australia

Dr Leon Hugo Survival characteristics of a wild population of Aedes aegypti in central Vietnam as determined by transcriptional age grading



Dr Tim Hurst Disasters and diseases ASMR

Jun -11 Australian Society of Medical Research lecture

Brisbane, Australia

Dr Tim Hurst Tanks, buckets and drums…oh my Sep-10 Australian Mosqutio Control Association


Dr Masego Johnstone Sars 1c, an active cysteine protease from Sarcoptes scabiei inhibits complement by degrading complement factors C3 and C5 (oral)

Aug-10 XII International Congress of Parasitology (ICOPA)



Correlative microscopy methods to investigate egg structure and development in schistosomes

Jul-10 Australian Conference of Microscopy and Microanalysis

Brisbane, Australia


Tissue-specific transcriptomics of the human helminth parasite Schistosoma mansoni

Aug-10 International Congress of Parasitology Associations



Advanced structural investigations of helminths

Mar-11 The International Congress of Liver Flukes, 96 Years of Opisthorchiasis: Past, Present and Future

Khon, Kaen Thailand


Functional genomics approaches for investigations into human schistosomiasis

Apr-11 Royal Golden Jubilee Postrgraduate Students Congress

Pattaya, Thailand

Prof Brian Kay Update on Wolbachia and other mosquito research

Apr-11 MARC Inc. Brisbane, Australia

Colm Keane LMO2 and BCL6 in DLBCL Jun-11 International Congress in Malignant Lymphoma

Lugano, Switzerland

Dr Douglas Kerlin Modelling of P. vivax Feb-11 Collaborator meeting Darwin, Australia

Prof Kum Kum Khanna New single-stranded DNA binding proteins involved in DNA damage repair

Nov-10 Indian Institute of Science Bengalore, India

Prof Kum Kum Khanna Cellular responses to DNA damage and their link with tumor suppression

Oct-10 Indo-Australia Biotechnology Conference

Brisbane, Australia

Prof Kum Kum Khanna Defective DNA damage response and cancer susceptibility

Nov-10 International Conference of Radiation Biology: Nanotechnology, Imaging and Stem Cell Research in Radiation Oncology

Chennai, India

Prof Kum Kum Khanna DNA damage repair and genome maintenance: discovery of new players

Jul-10 Murdoch Childrens Research Institute Melbourne, Australia

Prof Kum Kum Khanna Genome maintenance and role of single-stranded DNA binding proteins

Nov-10 Symposium entitled Current Trends in Radiation Biology and Radiation Countermeasures

Delhi, India

Prof Kum Kum Khanna Novel players involved in cell division cycle regulation

Jan-11 Cancer Genomics and Development Biology School, Utretch University

Utretch, Netherlands

Prof Rajiv Khanna Invited to chair (session on EBV immune-regulation) and participate as member of the International Scientific Committee

Sep-10 14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases

Birmingham, UK

Prof Rajiv Khanna Using polyepitope vaccine technology for chronic viral infections.

Mar-11 World Vaccine Summit New Delhi, India

Prof Rajiv Khanna Clinical assessment of cytotoxic T cell-based adoptive immunotherapy for the treatment of late stage nasopharyngeal carcinoma

Apr-11 3rd Australia-China Biomedical Research Conference

Melbourne, Victoria

Prof Rajiv Khanna EBV polyepitiope-based adoptive T cell therapy for nasopharngeal carcinoma.

Jun-11 5th International Symposium on Nasopharngeal Carcinoma

Penang, Malaysia

Prof Rajiv Khanna Profiling of HCMV-specific T cell responses in patients with Glioblastoma Multiforme

May-11 13th International CMV/BetaHerpesvirus Workshop.

Nuremberg, Germany

Dr Lutz Krause Studying the Intestinal Microbiota by pyrosequencing of the 16S RNA Gene

Mar-11 Workshop: Application of Genomics and Bioinformatics to Clinical Samples, Australian Infectious Disease Research Centre

Brisbane, Australia

Dr Lutz Krause Studying the human gut microbiota by high-throughput sequencing of the 16S ribosomal gene

Oct-10 7th Indo Australia Biotechnology Conference

Brisbane, Australia


high-throughput sequencing of the 16S Conference



Dr Lutz Krause Human microbiota, diabetes and high-throughput sequencing of the 16S RNA gene

Mar-11 Brisbane Lung Research Group Seminar Series

Brisbane, Australia

Petra Lahmann Adult weight change is associated with risk of aggressive prostate cancer: the Malmö Diet and Cancer Study, Sweden.

Oct-10 International Association for the Study of Obesity

Valencia, Spain

Min-Hsuan Lin An HIV-1 Tat mutant interfers with Rev Trafficking

Jun-11 Australian Centre for HIV and Hepatitis Research 7th Annual Workshop

Sunshine Coast, Queensland

Dr Felicity Lose Association of common variation in Kallikrein genes KLK5, KLK6, KLK12 and KLK13 with risk of prostate cancer and tumour aggressiveness

Aug-10 Prostate Cancer Foundation of Australia International Conference


Guangjin Lu The effect of endosymbiont Wolbachia on vector competence of Aedes aegypti



Kelly Loffler Developmental roles of the tumour suppressor menin

Oct-10 Brisbane Cell and Developmental Biology Meeting

Brisbane, Australia

Prof Barbara Leggett Serrated lesions: how they arise and what they mean in practice

Nov-10 Adelaide Gut Club Adelaide, Australia

Prof Barbara Leggett The serrated pathway in colonic tumorigenesis

May-11 Digestive Diseases Week Chicago, USA

Dr Kelli MacDonald Antigen presentation in graft-versus-host disease

Aug-11 ISEH International conference Melbourne, Australia

Dr Kelli MacDonald Stem cell mobilization with G-CSF promotes type-17 generation and scleroderma.

Mar-11 European Society of Bone Marrow Transplantation

Paris, France

Dr Kelli MacDonald Evolving tolerance strategies II BMT and chimerism

June/July 2011

TSANZ Postgraduate course Canberra, Australia

Prof Don McManus Comparative genomics of schistosomes Aug-10 ICOPA XII Melbourne, Australia

Prof Don McManus Large animal vaccines: Schistosoma japonicum zoonotic vaccines

Aug-10 ICOPA XII Melbourne, Australia

Prof Don McManus The interface of human and animal health: vaccine for Asian schistosomiasis

Oct-10 The Gairdner International Vaccine Symposium

Saskatoon, Canada

Prof Don McManus Integrated control of schistosomiasis in Asia

Nov-10 Tenth Regional Network Meeting for Asian Schistosomiasis and Other Helminth Zoonoses

Wuxi, China

Prof Don McManus Schistosome vaccines Nov-10 Ningxia Medical University Yinchuan, Ningxia, China

Prof Don McManus Development of a Transmission Blocking Vaccine for Asian Schistosomiasis.

Dec-10 Gold Coast Health and Medical Research Conference 2010


Prof Don McManus Integrated Control of Schistosomiasis in China

Apr-11 British Society of Parasitology Spring Meeting

Nottingham, UK

Dr Kate Markey Speaker Aug-10 The Transplantation Society Congress Vancouver, Canada

Dr Kate Markey Speaker Jun-11 The Transplantation Society of Australia and New Zealand

Canberra

Dr Kate Markey GVHD induces immune suppression via a selective defect in MHC class II antigen processing

Aug-10 The World Transplant Congress Vancouver, Canada

Prof Nick Martin Longitudinal twin studies of anxiety and depression in adult and adolescent twins

Oct-10 CELSE 2010 5th Conference of Epidemiological Longitudinal Studies in Europe

Paphos, Cyprus

Prof Nick Martin Translational medicine approaches to diseases of global impact - The genetic susceptibility to substance abuse

Nov-10 1st International Conference on Translational Medicine : the 13th Frank and Bobbie Fenner Conference

Canberra, Australia

Prof Nick Martin VisiGen Consortium Meeting Nov-10 VisiGen Consortium Meeting Amsterdam, Holland

Prof Nick Martin Connecting biobanks: the benefits for the researchers?

Nov-10 BBMRI-NL AMC Conference Connecting Biobanks

Amsterdam, Holland

Prof Nick Martin Binocular rivalry and bipolar disorder (Poster)

Dec-10 Golden Helix® Symposium Genetic Analysis in Translational Medicine

Athens, Greece

Prof Nick Martin Invited Faculty Mar-11 2011 International Workshop on Statistical Methodology for Human Genomic Studies

Boulder, Colorado

Prof Nick Martin Genome-wide association study of sleep disorders

Mar-11 Australasia Sleep Trials Network (ASTN) Biobanking

Sydney, Australia

Prof Nick Martin Genetics of environmental exposure : a GWAS for sun-related skin damage


Prof Nick Martin The genetics of complex traits: the GWAS revolution and beoynd

Apr-11 JCSMR School Seminars 2011 Canberra, Australia

Prof Nick Martin Personality, sex, and finger length: intersecting interests

Jun-11 41st Behaviour Genetics Association Meeting

Newport, USA

Prof Nick Martin The Queensland Twin Imaging Project: Genetics of brain structure and function

Jun-11 Imaging and Cognition Genetics Meeting

Os, Norway Jun-11 Imaging and Cognition Genetics Prof Nick Martin The Queensland Twin Imaging Project: Genetics of brain structure and function

Prof Nick Martin The Queensland Twin Imaging Project:

Page 117


Nico Martin Educational attainment: a genome wide association study in over 10,000 Australians

Nov-10 The 60th American Society of Human Genetics 2011

Washington DC, USA

Nico Martin Educational attainment : A meta-analysis of genome wide association studies


Brisbane, Australia

Dr Sarah Medland Overcoming heterogeneity to identify genes influencing handedness: results from the International Handedness Consortium

Oct-10 18th World Congress on Psychiatric Genetics

Athens, Greece

Dr Sarah Medland Invited to participate in forum Feb-11 Explore a Social Science Genetic Association Consortium

Boston, USA

Dr Sarah Medland Invited Faculty Mar-11 2011 International Workshop on Statistical Methodology for Human Genomic Studies

Boulder, USA

Dr Sarah Medland ENIGMA : Enhancing Neuro Imaging Genetics Through Meta-Analysis


Dr Sarah Medland Invited Teaching Position - Unravelling the genome in health and dusease

May-11 Croucher Advanced Study Institute Unravelling the genome in health and disease

Hong Kong

Dr Sarah Medland ENIGMA : Enabling Neuroimaging Genetics Through Meta-Analysis : progress six months in.


Newport, USA

Dr Sarah Medland Invited to instruct course Jun-11 Summer School IOP Kings College London, UK

Angela Mika Scabies Mite Serpins inhibit all three pathways of the human complement system and enhance Group A streptococcal growth (oral)



Prof Grant Montgomery Genome-wide association study identifies a locus at 7p15.2 associated with the development of moderate-severe endometriosis

Aug-11 Society for Reproductive Biology Conference

Sydney, Australia

Prof Grant Montgomery Genetics of endometriosis Oct-10 Fertility Society of Australia Adelaide, Australia

Prof Grant Montgomery Genetics of endometriosis Mar-11 Society for Gynecological Investigation Miami, USA

Miriam Mosing Genetics of left-right asymmetry in the brain: a twin study focusing on the hippocampus


Brisbane, Australia

Miriam Mosing Genetic influences on the relationship between personality and mortality


Athens, Greece

Miriam Mosing Genetic influences on mortality and its relationship to personality : a 16 year prospective study of aged twins


Brisbane, Australia

Miriam Mosing Genetic influences on mortality and its relationship to personality : a 16 year prospective study of aged twins


Newport, USA

Dr Christina Nagle Time to diagnosis does not influence stage of disease or survival among women with symptomatic ovarian cancer.

Nov-10 Clinical Oncology Society of Australia Annual Scientific Meeting


Dr Christina Nagle Alcohol and tobacco use predict survival in patients with esophageal squamous cell carcinoma.

Sep-10 Australasian Epidemiological Association, Annual Scientific Meeting

Sydney, Australia

Dr Christina Nagle Dietary glycaemic load, glycaemic index, carbohydrates and risk of ovarian cancer

Sep-10 Australasian Epidemiological Association, Annual Scientific Meeting

Sydney, Australia

Sujeevi Nawaratna Tissue-specific transcriptomics of the human helminth parasite, Schistosoma mansoni

Jul-10 Australian Conference of Microscopy and Microanalysis

Brisbane, Australia

Dr Jamie Nourse EBV-microRNA May-11 Diamantina Institute Lecture Series Brisbane, Australia

Dr Dale Nyholt The indirect estimation of risk using genomic data

Jun-10 PRIVATE Gen Nuremberg, Germany

Dr Dale Nyholt Examining the genetics of migraine and its symptoms

Oct-10 Colloquium organised by the William James Graduate School, VU

Amsterdam, The Netherlands

Tracy O'Mara A genome-wide association study to identify genetic markers associated with endometrial cancer grade

May-11 ASMR Postgraduate Student Conference, Health and Medical Research Awards Finalist

Brisbane, Australia

Dr Colleen Olive Understanding Toll-like receptor signaling in dendritic cells with a view to immune modulation

Sep-10 Bioengineering Department Seminar Series, Berkeley

California, USA

Dr Catherine Olsen Towards melanoma risk prediction Jul-10 Queensland Public Health Forum Brisbane, Australia




Assoc Prof Grant Ramm

Stellate cells and liver fibrosis Aug-10 World Congress of the International Society for Hepatic Sinusoidal Research

Pasadena, USA

Assoc Prof Grant Ramm

Session Chair: Mechanisms of iron-mediated tissue injury, ER stress

May-11 World Congress on Iron Metabolism Vancouver, Canada

Dr Jodie Painter Application of GWA data to address issues of genetic loading in complex human diseases

Jul-11 Genetics Society of Australasia annual meeting

Canberra, Australia

Dr Jodie Painter Genome-wide linkage scan for familial dizygotic twinning

Sept-11 Endocrine Society of Australia and Society for Reproductive Biology Annual Scientific Meeting

Sydney, Australia

Dr Jodie Painter Genetics of complex diseases: endometriosis

Nov-11 University of Connecticut Genetics Department

Storrs, USA

Dr Jodie Painter Genome-wide association study identifies two candidate loci for endometriosis

Apr-11 Australasian Human Gene Mapping (Genemappers) Conference

Hobart, Australia

Dr Jodie Painter Genetics of endometriosis Mar-11 Queensland Endometriosis Support Association (QENDO) information night

Brisbane, Australia

David Pattinson A novel DNA vaccine delivery strategy using bi-specific antibodies to target dendritic cells with bacterial minicells encapsulating plasmid DNA and recombinant protein


Darren Pickering Testing scabies mite complement Inhibitors under physiological conditions (poster presentation)



Dr Joseph Powell Statistical programming Dec-10 ICTE UQ – International postgraduate course at The University of Queensland

Brisbane, Australia

Prof Lawrie Powell Iron overload - a global perspective Feb-11 Asian Pacific Association for the Study of the Liver

Bangkok, Thailand

Andrew Redmond Parenteral immunization with cholera toxin induces cellular immune responses


Dr David Reid Novel antimicrobials against Pseudomonas aeruginosa

Nov-10 Boden Research Conference: Metals in Biological Systems

Canberra, Australia

Dr David Reid Is it asthma or COPD or both? May-11 Australian Lung Foundation Education Day

Brisbane, Australia

Dr David Reid Iron and Pseudomonas aeruginosa Nov-10 Brisbane Lung Group Brisbane, Australia

Dr David Reid Neutrophil function in cystic fibrosis Nov-11 Brisbane Lung Group Brisbane, Australia

Dr David Reid Transition to adult care in cystic fibrosis (CF)

Jul-10 Queensland Cystic Fibrosis Education Day

Brisbane, Australia

Miguel Renteria Multivariate Genome-wide association study of height, occipito-frontal circumference and total brain volume

Apr-11 8th GeneMappers Conference Hobart, Tasmania, Australia

Renee Robb Speaker Feb-11 European Bone Marrow Transplant Society

Paris, France

Renee Robb Speaker Jun/Jul-11 President’s Prize Session, TSANZ Canberra, Australia

Dr Peter Ryan Development of on-line decision support tools for surveillance and control of mosquitoes and vector-borne diseases in Queensland

Sep-10 Australian Mosquito Control Association


Dr Chris Schmidt Characteristics of immunotherapeutic dendritic cells (Keynote)

Sep-11 Reliable Cancer Therapies Roundtable Brussels, Belgium

Dr Chris Schmidt MCM matured mo-DC with autologous tumour as antigen source

Sep-11 Reliable Cancer Therapies Roundtable Brussels, Belgium

Dr Chris Schmidt Characteristics of successful immune responses to melanoma

Oct-11 Perth Tumour Immunology Group Annual Scientific Meeting

Perth, Australia

Dr Chris Schmidt How does cancer immunotherapy work? Oct-11 National Centre for Asbestos Related Diseases Annual Scientific Meeting, Perth

Perth, Australia

Dr Chris Schmidt Successful anti-tumour immune responses are broadly targeted

Dec-11 Australasian Society for Immunology Annual Meeting,

Perth, Australia

Dr Chris Schmidt Burnet oration: Subverting paradigms Dec-11 Tumour Immunology Workshop, Australasian Society for Immunology Annual Meeting

Perth, Australia

Dr Chris Schmidt Dendritic cell immunotherapy of advanced metastatic melanoma – how does it really work?

Feb-11 University of Otago Wellington Cancer Symposium

Wellington, New Zealand

Maggy Sikulu Age grading tools for Anopheles mosquitoes

Sep-10 Australian Mosquito Control Association


Haran Sivakumaran Arginine methylation increases the stability of Tat

Jun-11 Australian Centre for HIV and Hepatitits Research 7th Annual Workshop


Page 119


Dr Tina Skinner-Adams The Plasmodium falciparum neutral aminopeptidases: valid targets for novel anti-malarial drugs

Aug-10 International Congress of Parasitology Melbourne. Australia

Dr Amanda Spurdle Understanding unclassified variants in molecular diagnosis.

Nov-10 Human Variome Project and HGSA ASM joint meeting – understanding Human Variation


Dr Amanda Spurdle Translational research capabilities of ANECS

Feb-10 Australian & New Zealand Gynaecological Oncology Group Annual Meeting

Noosa, Australia

Dr Amanda Spurdle Mismatch repair gene unclassified variants – research in progress and suggestions for collaborative opportunities.

May-10 InSIGHT / Human Variome Project meeting

Paris, France

Dr Amanda Spurdle Update on the moderate-risk study, assessing risk associated with the BRCA1 R1699Q variant

May-10 Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Meeting

London, UK

Dr Amanda Spurdle Pathology markers as predictors of BRCA1/2 mutation status; Results from segregation studies of the BRCA1 R1699Q variant; Activities of the ENIGMA Splicing Working Group.

Sep-10 Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Meeting

Milan, Italy

Dr Amanda Spurdle ENIGMA Splicing Working Group presentations: Clinical interpretation of splicing aberrations; ENIGMA variants to consider for splicing analysis

Jun-11 Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Meeting

Stockholm, Sweden

Dr Brett Stringer Targeting EphA3 in AML and other cancers Oct-10 19th Annual RBWH Health Care Symposium

Brisbane, Australia

Assoc Prof Nathan Subramaniam

Non-HFE haemochromatosis Nov-10 Boden Research Conference on Metals in Biological Systems: Structure, Catalysis and Metabolism

Canberra, Australia

Prof Andreas Suhrbier Chikungunya virus disease: Pathogenesis, animal models and interventions.

Jun-11 Australasian Society for Microbiology Hobart, Australia

Prof Andreas Suhrbier Ingenol mebutate: a new topical treatment for actinic keratoses and non-melanoma skin cancer with a novel mechanism of action

May-11 Australasian Society for Dermatology Research

Perth, Australia

Prof Andreas Suhrbier Chikungunya virus, mice, monkeys, macrophages and money

Aug-10 SMBS Seminar Series Adelaide, Australia

Prof Andreas Suhrbier The development of ingenol mebutate (PEP005) as a new chemotherapeutic agent

Oct-10 Peter MacCallum Cancer Centre Melbourne, Australia

Prof Andreas Suhrbier Chikungunya virus disease: models and interventions

Oct-10 7th Indo-Australia Biotechnology Conference

Brisbane, Australia

Prof Andreas Suhrbier Viral arthritis and chikungunya virus disease Sep-10 Griffith Medical Research College Retreat

Brisbane, Australia

Prof Andreas Suhrbier Chikungunya virus arthritis in adult wild-type mice

Aug-10 Brisbane Immunology Group Brisbane, Australia

Prof Andreas Suhrbier Biological agents in war, terror and the everyday

Aug-10 Sydney Nursing School, University Sydney

Sydney, Australia

Prof Andreas Suhrbier Chikungunya virus, mice, monkeys, macrophages and money

Aug-10 University of Adelaide School of Molecular and Biomedical Sciences Seminar series

Adelaide, Australia

Prof Andreas Suhrbier Ingenol mebutate: a new topical treatment for actinic keratoses and non-melanoma skin cancer with a novel mechanism of action

Jun-11 LEO Pharma Copenhagen, Denmark

Prof Andreas Suhrbier Chikungunya virus; expression profile of a viral arthritis.

Nov-10 Joint QIMR, ACVD, Emory Vaccine Center Meeting

Atlanta, USA

Prof Andreas Suhrbier The development of ingenol mebutate: a new topical skin cancer treatment with a novel mode of action

Nov-10 Leiden University Medical Center: Molecular tumor genetics seminar series

Leiden, The Netherlands

Dr Clara Tang Invited Faculty - Tutorial on copy number analysis

Mar-11 2011 International Workshop on Statistical Methodology for Human Genomic Studies

Boulder, Colorado

Dr Clara Tang A tool to test for functional enrichment of GWAS hits


Bryony Thompson Clinical evaluation of mismatch repair gene sequence variants using qualitative, analytical and molecular methods

Aug-10 kConFab familial aspects of cancer conference, 2010

Kingscliff, Australia

Assoc Prof Katharine Trenholme

Identification of lead gametocidal agents by high throughput screening




Assoc Prof Katharine Trenholme

Identification of lead gametocidal agents by high throughput screening





Dr Patricia Valery Discussing strategies for successful community engagement

Nov-10 Tonkin’s Indigenous Health Care Delivery Conference

Brisbane, Australia

Dr Patricia Valery The developmental origins of childhood obesity: a snapshot from the Torres Strait

Oct-10 Royal Brisbane and Women’s Hospital Health 19th Annual Health Care Symposium

Brisbane, Australia

Dr Patricia Valery Adapting an existing Supportive Care Needs tool to be used with Indigenous cancer patients.

Mar-10 Cancer Care Coordination Conference, Clinical Oncological Society of Australia


Dr Antiopi Varelias Recipient HO-1 prevents GVHD. May-11 American Association of Immunology San Francisco, USA

Karin Verweij Meta-analysis of genome-wide association studies on cannabis use initiation and quantity of use


Athens, Greece

Karin Verweij Genetics of personality Apr-11 8th GeneMappers Conference Hobart, Tasmania, Australia

Karin Verweij The genetic etiology of cannabis use May-11 2011 Australian Society for Medical Research Postgraduate Student Conference

Brisbane, Australia

Karin Verweij The genetic etiology of cannabis use Jun-11 41st Behaviour Genetics Association Meeting

Newport, USA

Prof Peter Visscher Genetics of complex traits Jul-10 Western Australian Institute of Medical Research seminar

Perth, Australia

Prof Peter Visscher Genetics of complex traits in human populations

Aug-10 World Congress of Genetics Applied to Livestock Production (plenary)

Leipzig, Germany

Prof Peter Visscher Genetic analysis of complex traits Aug-10 Max Planck Institute seminar Leipzig, Germany

Prof Peter Visscher Novel analyses of GWAS data Aug-10 Illumina workshop Brisbane, Australia

Prof Peter Visscher Missing heritability Sept-10 Peter MacCallum Institute seminar Melbourne, Australia

Prof Peter Visscher Genetic architecture of complex traits Sept-10 Belgium Academy of Science thinktank workshop

Rome, Italy

Prof Peter Visscher Genetic architecture of complex traits Oct-10 Indo-Australia Biotechnology Conference

Brisbane, Australia

Prof Peter Visscher Genetic architecture of complex traits Nov-10 Institute of Psychiatry seminar London, UK

Prof Peter Visscher Genome partitioning of genetic variation Feb-11 Erasmus University seminar Rottterdam, The Netherlands

Prof Peter Visscher Genome partitioning of genetic variation Feb-11 University of Alabama seminar Birmingham, USA

Prof Peter Visscher Genome partitioning of genetic variation Feb-11 Emory University seminar Atlanta, USA

Prof Peter Visscher Genome partitioning of genetic variation Mar-11 Broad Institute seminar Boston, USA

Prof Peter Visscher Genome partitioning of genetic variation Mar-11 Harvard Medical School seminar Boston, USA

Prof Peter Visscher New analyses of GWAS data Mar-11 Genetics of ankylosing spondylitis conference presentation

Shanghai, China

Prof Peter Visscher Genome partitioning of genetic variation May-11 Biology of Genomes session chair and presentation

Cold Spring Harbor, USA

Dr Graeme Walker Differential roles of the pRb and p53 pathways in naevo and melanoma genesis

Nov-10 7th Annual International Melanoma Congress

Sydney, Australia

Dr Graeme Walker Transgenic mice as models for naevi and melanoma

May-11 International Skin Cancer Research Workshop

Brisbane, Australia

Dr Graeme Walker Genetically modified mice as UVR-induced melanoma

Nov-10 Australian Health and Medical Research Conference


Logan Walker The role of germ-line DNA copy number variation in familial breast cancer risk.

Aug-10 KConFab annual meeting: Familial Cancer and Research and Practice


Logan Walker The role of germ-line DNA copy number variation in familial breast cancer risk

Sep-10 Australasian Microarray and Associated Technologies Association (AMATA) Meeting

Hobart, Australia

Logan Walker Germ-line DNA copy number variation and familial breast cancer development

May-11 New Zealand Society of Oncology Auckland, New Zealand

Logan Walker Copy number variants as modifiers of BRCA1 associated breast cancer risk and progression

Jun-11 Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) Meeting

Stockholm, Sweden

Logan Walker ENIGMA Splicing Working Group Project 1: Quality control and protocol comparison

Jun-11 Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Meeting

Stockholm, Sweden

Dr Daniel Wallace Investigating the role of Ataxia Telangiectasia Mutated (ATM) in iron homeostasis

Sept-10 Griffith Medical Research College Retreat

Brisbane, Australia

Dr Daniel Wallace Blunted hepcidin response to inflammation in the absence of Hfe and Tfr2

Nov-10 Boden Research Conference on Metals in Biological Systems: Structure, Catalysis and Metabolism

Canberra, Australia

Dr Daniel Wallace Blunted hepcidin response to inflammation in the absence of Hfe and Tfr2

Jun-11 London Iron Metabolism Group Meeting: Iron and immune responses

London, UK

Page 121


Dr Penny Webb Ovarian Cancer Patterns of Care Study: management of women with invasive ovarian cancer in Australia in 2005

Feb-11 Australian and New Zealand Gynaecological Oncology Group


Dr Penny Webb Epidemiology in real life: case-control studies

Aug-10 Master of Public Health Program, The University of Queensland

Brisbane, Australia

Dr Penny Webb Epidemiology in real life: dealing with error Apr-11 Master of Public Health Program, The University of Queensland

Brisbane, Australia

Ting Wei Cell factors and HIV-1 reverse transcripiton Jun-11 Australian Centre for HIV and Hepatitits Research 7th Annual Workshop

Sunshine Coast, Qld

Phillip Whiley Identification of clinically significant splicing aberrations for intronic BRCA1 and BRCA2 variants and the association of alternative splice isoform regulation with pathogenicity

Aug-10 kConFab Familial Aspects of Cancer Conference 2010


Prof Emma Whitelaw The genetics of epigenetics Jul-10 Mater Medical Research Institute Annual Symposium

Brisbane, Australia

Prof Emma Whitelaw Epigenetics and the determination of phenotype

Jul-10 School of Medical Sciences, UNSW Sydney, Australia


Jul-10 Children's Medical Research Institute, Westmead

Sydney, Australia

Prof Emma Whitelaw Epigenetics in mammals Jul-10 2nd Nutrigenomics Symposium Adelaide, Australia

Prof Emma Whitelaw Transgenerational epigenetic inheritance Aug-10 Telethon Institute for Child Health Research

Perth, Australia


Sep-10 Asia Millipore Bioforum on Epigenetics and Stem cells

Singapore, Australia


Sep-10 Asia Millipore Bioforum on Epigenetics and Stem cells

Beijing, China

Prof Emma Whitelaw Transgenerational epigenetic inheritance Sep-10 Asia Millipore Bioforum on Epigenetics and Stem cells

Taipei, Taiwan

Prof Emma Whitelaw Epigenetics in mammals Sep-10 Cold Spring Harbour Asia Conference on Molecular Switches and Genome Function in Stem Cells and Development

Suzhou, China

Prof Emma Whitelaw Transgenerational epigenetic inheritance Sep-10 ANZSCDB President's Medal and Lecture, OzBio2010



Oct-10 7th Nestle International Nutrition Symposium

Lausanne, Switzerland

Prof Emma Whitelaw Transgenerational epigenetic inheritance Dec-10 Howard Hughes Medical Institute, Symposium on the Epigenome

Bethesda, USA


Feb-11 IUBMB Jubilee Lecture and Medal, Miami 2011 Winter Symposium

Miami, USA


Mar-11 Center for Developmental Biology Symposium Epigenetic Landscape in Development and Disease

Kobe, Japan

Prof Emma Whitelaw Transgenerational epigenetic inheritance Apr-11 Plenary Lecture, Noncoding RNA, Epigenetic Memory and the Environment

London, UK

Prof Emma Whitelaw Epigenetics in mammals Mar-11 Keystone Environmental Epigenomics North Carolina, USA

Prof Emma Whitelaw Transgenerational epigenetic inheritance May-11 Workshop on Epigenetics, Garvan Institute

Sydney, Australia

Prof Emma Whitelaw Transgenerational epigenetic inheritance May-11 Fellows Lecture, Australian Academy of Science, Shine Dome

Canberra, Australia


May-11 Plenary Lecture, Advanced Studies Institute, Hong Kong University

Hong Kong


May-11 Workshop Lecture, Advanced Studies Institute, Hong Kong University

Hong Kong

Prof David Whiteman Obesity and cancer May-11 Queen Elizabeth II Hospital Grand Rounds

Brisbane, Australia

Prof David Whiteman Careers in medical research May-11 Australian Society for Medical Research Student Conference

Brisbane, Australia

Prof David Whiteman QSkin - sun and health study May-11 1st International Conference on UV and Skin Cancer Prevention

Copenhagen, Denmark

Prof David Whiteman The causes of melanoma Jun-11 8th International Skin Cancer Conference


Prof David Whiteman The epidemiology and genetics of oesophageal cancer

Jun-11 15th Annual Gastroenterology Update, Gastroenterological Society of Queensland

Coolum, Australia

Prof David Whiteman Oesophageal Cancer Research Progress Nov-10 PROBE-NET annual meeting Melbourne, Australia

Prof David Whiteman Blue Sky Epidemiology Feb-11 Queensland Epidemiology Group Brisbane, Australia


Prof David Whiteman Oesophageal Cancer Research Progress Nov-10 PROBE-NET annual meeting

Prof David Whiteman Blue Sky Epidemiology


Prof David Whiteman Blue Sky Epidemiology


Feb-11 Queensland Epidemiology Group Brisbane, Australia


Feb-11 Queensland Epidemiology Group Brisbane, Australia



Prof David Whiteman Skin cancer research in Queensland - an overview

Oct-10 Pan-Pacific Skin Cancer Consortium Meeting

Tucson, USA

Dr John Whitfield Common variants of large effect : do they exist, do they matter?


Dr Susan Woods The pigment cell specific microRNA, miR-211, as a novel tumour suppressor for melanoma

Nov-11 7th International Melanoma Research Sydney, Australia

Dr Susan Woods miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma

May-11 ASMR Awards presentation Brisbane, Australia

Dr Naomi Wray Recent advances in our understanding of the genetics of pscyhiatric disorders

Aug-10 Plenary,Youth Mental Health Symposium

Brisbane, Australia

Dr Naomi Wray Genetics of psychiatric disorders:assimilating genome-wide association and genetic epidemiology studies

Sept-10 University of Queensland, Dept Psychiatry

Brisbane, Australia

Dr Naomi Wray Prospects for genetic testing in psychiatry Oct-10 Plenary, World Congress Psychiatric Genetics

Athens, Greece

Dr Naomi Wray Whole-genome analysis of GWAS data for complex traits

Oct-10 Symposium, World Congress Psychiatric Genetics

Athens, Greece

Dr Naomi Wray Insights into genetic architecture from genetic epidemiology and GWAS

Oct-10 Symposium, World Congress Psychiatric Genetics

Athens, Greece

Dr Naomi Wray Use of GWAS for prediction of genetic risk to disease

Oct-10 Plenary, GWAS mega-analysis for complex diseases: Satellite workshop of the International Conference of Systems Biology

Edinburgh, Scotland

Dr Naomi Wray Insights into genetic architecture from GWAS: Looking for the "missing heritability"

Dec-10 Bioinformatics Summer School Melbourne, Australia

Dr Naomi Wray Putting synthetic associations into perspective

Apr-11 Australian GeneMappers Meeting Hobart, Australia

Dr Margie Wright Neuroimaging genetics, finding genes for brain function and dysfunction

Sep-10 Queensland Brain Institute, The University of Queensland Seminar Series

Brisbane, Australia

Dr Margie Wright Unravelling the genetic mechanisms influencing the human brain in health, illness, youth and old age

Dec-10 The Australasian Society for Psychiatric Research 2010 Conference: Glial-Neuronal Networks in Neuropsychiatry

Sydney, Australia

Assoc Prof Joanne Young

Serrated neoplasia update Jul-10 Norris Comprehensive Cancer Centre Seminar

Los Angeles, USA


Serrated polyposis risk factors Nov-10 NZ Gastroenterology Society Meeting Auckland, New Zealand


Epigenetics update Oct-10 Australian Gastroenterology Week Gold Coast, Australia


Molecular pathology of colorectal cancer Oct-10 Australian Gastroenterology Week Gold Coast, Australia


Origin of cancers in serrated polyposis Oct-10 Consensus Meeting on Serrated Neoplasia

Cleveland, USA


The mucosa in serrated polyposis Oct-10 Consensus Meeting on Serrated Neoplasia

Cleveland, USA

Page 123

graDuateD StuDentSStudent University Supervisor Thesis title

BSC (HONS)

Ainslie CAMERON

QUT David McMillan Identification of the virulence gene, sicG, in Australian clinical isolates of Streptococcus dysgalactiae subspecies equisimilis

Carly PERRY QUT Geoffrey Gobert, Melissa Burke, Don McManus

Comparison of hepatic gene expression in mouse strains with contrasting pathology during infection with Schistosoma japonicum

Cornel MIRCIOV Bond University

Greg Anderson Characterisation of iron-related gene expression in the mouse lung

Ai Hwee KHO University of Tunku Abdul Rahman, Malaysia

Leon Hugo Combined effects of nutritional stress and Wolbachia infection on the vector competence of Aedes aegypti for dengue

Timothy REEKS QUT Keyur Dave, Jeff Gorman

Identification of cellular pathways perturbed by the human respiratory syncytial virus attachment protein

Yadveer GREWAL

QUT Marcus Hastie, Jeff Gorman

Quantitative proteomics: using iTRAQ to examine changes involved in breast cancer mammosphere formation

Annaliese WOODS GU Kathy Andrews Antimalarial action of HDAC inhibitors

Priscilla GOH UQ Katja Fischer, Angela Mika

The role of peritrophins in scabies mite Immunity

Emma SEDLACEK

UQ Amanda Spurdle, Phillip Whiley

Assessing the clinical relevance of rare sequence variants in BRCA1 and BRCA2 genes

Nurul OSMAN UQ Kelli MacDonald, Geoff Hill

Characterisation of molecular mediators of murine chronic graft-versus-host disease

PHD

Suzanne MOORE UQ Adèle Green, Gail Garvey

A comparative study of cancer incidence, diagnosis, treatment and survival between Indigenous and non-indigenous people in Queensland

Simin ARABSHAHI

UQ Adèle Green, Jolieke van der Pols

Longitudinal change in anthropometric characteristics & diet quality in Australian adults

Jennifer MCCARRON

QUT Andrew Boyd The role of the Eph and ephrin proteins in prostate cancer

Hau Phuc TRAN UQ Brian Kay Relationships between dengue vector abundance, household water storage practices and new water supply Infrastructure in Southern Vietnam

Amber GLANFIELD

UQ Malcolm Jones Iron biology of schistosomes: molecular characterisation and vaccine potential of iron homeostasis proteins

David HEWETT UQ Barbara Leggett Communication between doctors and the quality of patient care: An intergroup perspective

Mikail RUBINOV UNSW Michael Breakspear Brain networks

Meru SHEEL QUT Michael Batzloff Immunogenicity and protective efficacy of an anti-Streptococcus pyogenes vaccine candidate in multiple animal species

Kate MARKEY UQ Kelli MacDonald, Geoff Hill

Antigen presentation and inflammation in allogeneic bone marrow transplantation

MASTERS

Andrew LALOO UQ David Harrich Analysis of RNA binding and heat shock proteins in the regulation of HIV-1 reverse transcripiton

Lisa WHOP ANU Patricia Valery, Gail Garvey

Cadetship

Audra DE'WITT UQ Patricia Valery, Gail Garvey

Health behaviours in Indigenous and non-Indigenous people and their associations with asthma

Hosam ZOWAWI

GU David McMillan Development and evaluation of a rapid real-time PCR based diagnostic tool to detect pathogenic bacteria colonising catheters.

Elizabeth LEDDY UQ Nathan Subramaniam The role on hemojuvelin and matriptase-2 in iron metabolism

Legend

ANU Australian National University

GU Griffith University

QUT Queensland University of Technology

UNSW University of New South Wales

UQ The University of Queensland


StuDent aWarDSRecipient Bestower of award Date Award Reason

Franziska Bieri Queensland Tropical Health Alliance

Jun-11 Travel Award Conference attendance

Franziska Bieri ASMR May-11 Postgraduate Student Conference The People’s Choice prize for the best poster presentation: The Magic Glasses.

Franziska Bieri QIMR 2011 QIMR PhD Award

Gabriëlla Blokland QIMR Jul-10 QIMR PhD Top-up Award Scholarship Top-up

Gabriëlla Blokland QIMR 2010 ANZ Trustees PhD scholarship in Medical Research

PhD scholarship

Gabriëlla Blokland ANZ Trustees Jan-11 Travel award PhD scholarship

Gabriëlla Blokland ATR Mar-11 Travel award Conference attendance

Gabriëlla Blokland UQ School of Psychology May-11 Honours scholarship Conference attendance

Catherine Bond QIMR 2011 PhD Award

Zara Bruce QIMR Jan-11 Honours scholarship

Ainslee Cameron QIMR 2011 Honours scholarship

Melody Cheong QIMR 2011 Honours scholarship

Ken Dutton-Regester QIMR 2010 QIMR PhD Award

Ken Dutton-Regester Australian Academy for Technological Sciences and Engineering

2011 ATSE Young Science Ambassador Award

Ken Dutton-Regester QIMR 2011 QIMR PhD Top-up Award

Ken Dutton-Regester QIMR 2011 QIMR Postgraduate Student Travel Award

Ken Dutton-Regester CCQ 2011 Cancer Council Queensland Travel Grant

Imogen Gillions QIMR Aug-10 Travel award Conference attendance

Catherine Gordon QIMR 2011 QIMR PhD Award

Kimberley Jones Boehringer Ingelheim Fonds

Dec-10 Travel award

Kimberely Jones QIMR 2011 QIMR PhD Award

Yee Leow ACVD Feb-11 ACVD Edward Jenner PhD Scholarship

Yi Chieh Lim QIMR 2010 QIMR PhD Award

Yi Lu QIMR 2010 QIMR PhD Award

Rachael McGeorge Australian Society for Parasitology

Jul-10 Travel award Travel to USA

Rachael McGeorge QIMR Jun-11 QIMR PhD Award

Kate Markey ASI Aug-10 Travel award Conference attendance

Kate Markey The Transplant Society Aug-10 Astellas Pharma Educational Grant A grant received for submission of one of the top 10 scored abstracts by a Young Investigator for The Transplantation Society annual meeting, to be held in Vancouver Canada

Kate Markey TSANZ Jun-11 Amgen Young Investigator Award Awarded for the Best Presentation in the Field of Laboratory Research, TSANZ meeting

Kate Markey School of Medicine Jun-10 Selected to attend the 60th Meeting of Nobel Laureates in Lindau, Germany

After a competitive selection process, awarded a place as a “Young Researcher” delegate at this meeting. Part of the award includes full travel support to attend.

Kate Markey TSANZ Jun-11 Young Investigator award Quality of research by young investigator

Kate Markey NHMRC Jan-11 Clinical Training Fellowship

Nico Martin QIMR Aug-10 Postgraduate Student Travel Award Conference attendance

Nico Martin ATR Oct-10 Travel award Conference attendance

Nico Martin ANZ Trustees Jan-11 ANZ Trustees PhD scholarship in Medical Research

PhD scholarship

Nico Martin UQ School of Psychology

May-11 Travel award Conference attendance

Cornel Mirciov QIMR 2010 QIMR Honours Award

Marcela Montes de Oca QIMR 2011 QIMR Honours Award

Brian Morrison CCQ Sep-10 Travel award Conference attendance

Brian Morrison QIMR Sep-10 Travel award Conference attendance

Miriam Mosing World Congress on Psychiatric Genetics

Aug-10 Early Career Investigator Program Travel Award


Page 125

Recipient Bestower of award Date Award Reason

Miriam Mosing ANZ Trustees Jan-11 ANZ Trustees PhD scholarship in Medical Research

PhD scholarship

Miriam Mosing ATR Mar-11 Travel award Conference attendance

Miriam Mosing UQ School of Psychology May-11 Travel award Conference attendance

Miriam Mosing Behavior Genetics Association

Jun-11 Travel award Conference attendance

Sujeevi Nawaratna QIMR 2010 QIMR PhD Award

Tracy O'Mara ASMR May-11 ASMR Postgraduate Student Conference, Health and Medical Research Awards Finalist

Thomas Partridge QIMR 2011 Honours scholarship

David Pattinson Australian Society for Parasitology

Aug-10 Travel award Conference attendance

David Pattinson QIMR 2011 QIMR PhD Award

Chris Peatey Australian Society for Parasitology

Sep-10 Travel award Travel to Melbourne/Researcher exchange

Melinda Protani QIMR 2011 QIMR PhD Award

Melanie Rampton QIMR 2011 Honours scholarship

Andrew Redmond Australian Society for Parasitology


Simone Reynolds Australian Society for Parasitology & ARC/NHMRC Network for Parasitology

Mar-11 ASP and ARC/NHMRC Network for Parasitology Travel Award 2011


Simone Reynolds Australian Society for Parasitology

Feb-11 Australian Society for Parasitology JD Smyth Postgraduate Travel Award 2010

International Summer School (Germany) and Researcher Exchange (Sweden) ($8000)

Simone Reynolds QIMR 2010 QIMR Postgraduate Travel Award 2010 Conference attendance

Sophie Schussek Australian Society for Parasitology


Maggy Sikulu Aust Mosqutio Control Association

Sept-10 Best Student Presentation

Maggy Sikulu QIMR 2011 QIMR PhD Award

Daniel Smith Prince Charles Hospital Research Foundation

Feb-11 PhD scholarship

Dulangi Sumanadasa Australian Society for Parasitology

Jul-11 ASP Travel Award

Aaron Thrift QIMR 2011 QIMR PhD Award

Karin Verweij QIMR Jul-10 QIMR PhD Top-up Award

Karin Verweij QIMR Jul-10 Postgraduate Student Travel Award Conference attendance

Karin Verweij World Congress on Psychiatric Genetics

Aug-10 Early Career Investigator Program Travel Award


Karin Verweij ANZ Trustees Jan-11 ANZ Trustees PhD scholarship in Medical Research

PhD scholarship

Karin Verweij ATR Apr-11 Travel award Conference attendance

Karin Verweij UQ School of Psychology

Apr-11 Travel award Conference attendance

Karin Verweij Behavior Genetics Association

Jun-11 Travel award Conference attendance

Karin Verweij UQ School of Psychology

Sep-10 2010 Psychology Student Research Excellence Award

Annaliese Woods Australian Society for Parasitology

Jul-11 ASP Travel Award

LegendACVD Australian Centre for Vaccine Development

ARC Australian Research Council

ASI Australasian Society of Immunology

ASMR Australian Society of Medical Research

ATR Australian Twin Registry




PCRFA Prostate Cancer Research Foundation Australia


Student awards | continued

PCRFA


Prostate Cancer Research Foundation Australia

The Transplantation Society of Australia and New ZealandThe Transplantation Society of Australia and New ZealandThe Transplantation Society of Australia and New Zealand


patentS

patent families managed by QimrTitle Inventor(s) Application Number

Novel molecules Toni Antalis; John Hooper PCT/AU1998/000085

Immunogenic agent and pharmaceutical composition for use against homologous and heterologous pathogens

Michael Good; Mary Stevenson PCT/AU2004/000870

Polytope vaccines Andreas Suhrbier; Scott Thomson; Rajiv Khanna; Scott Burrows; Barbara Coupar; Denis Moss

PCT/AU1995/000461

Synthetic peptides and vaccines comprising the same Juan Cooper; Wendy Relf; Michael Good; Allan Saul

PCT/AU1995/000681

Cytotoxic T-cell epitopes Denis Moss; Scott Burrows; Rajiv Khanna; Beverley Kerr; Jacqueline Burrows; Andreas Suhrbier

PCT/AU1995/000140

EBV CTL epitopes Rajiv Khanna; Beverley Kerr; Ihor Misko; Denis Moss; Scott Burrows

PCT/AU1997/000328

CTL epitopes from EBV Martina Sherritt; Scott Burrows; Rajiv Khanna PCT/AU1998/000531

EBV peptide epitopes, polyepitopes and delivery system therefor Rajiv Khanna; Jaikumar Duraiswamy PCT/AU2003/001451

Novel hCMV cytotoxic T cell epitopes, polyepitopes, composition comprising same and diagnostic and prophylactic and therapeutics uses therefor

Rajiv Khanna; Rebecca Elkington; Susan Walker

PCT/AU2002/000829

Human cytomegalovirus immunotherapy Rajiv Khanna PCT/AU2005/001798

Peptide compounds Istvan Toth; William Gibbons PCT/GB1993/001558

Novel human ssDNA binding proteins and methods of cancer diagnosis Kum Kum Khanna; Derek Richard; Malcolm White

PCT/AU2008/000181

Cancer drug targets and methods of diagnosis Andrew Boyd; Bryan Day; Brett Stringer PCT/AU2009/000672

Human cytomegalovirus immunotherapy Rajiv Khanna 61/347,352

Qimr patent families managed outside QimrTitle Inventor(s) Application Number

Receptor ligand system and assay Andrew Boyd US 1998/104340

Eph/ephrin mediated modulation of cell adhesion and tumour cell metastasis Andrew Boyd PCT/AU2004/000142

A method of treatment Andrew Boyd PCT/AU1999/000931

Differentiation modulating agents and uses therefor Johannes Prins PCT/AU2005/000008

Melanoma-associated MHC Class 1 Associated oligopeptide and its use Chris Schmidt PCT/EP2006/008533

Method for screening for anticancer agents Kum Kum Khanna PCT/GB2008/003390

A novel growth factor and a genetic sequence encoding same Nicholas Hayward PCT/AU1996/000094

Page 127

patent families resulting from industry Sponsored contract research performed at Qimr

Title Inventor(s) Application Number

Treatment of virally induced lesions Andreas Suhrbier PCT/AU2008/000596

Use of angeloyl-substituted ingenones in combination with other agents to treat cancer Andreas Suhrbier; Peter Parsons

PCT/AU2006/001700

Treatment of solid tumours Andreas Suhrbier PCT/AU2005/001827

Chaperonin 10 modulators of toll-like receptors inducible cytokine and cytokine secretion Andreas Suhrbier PCT/AU2005/000041

Treatment of prostate cancer Peter Parsons PCT/AU2001/000966

Therapeutic agents I Andreas Suhrbier; Peter Parsons

PCT/AU2001/000679

Therapeutic agents II Andreas Suhrbier; Peter Parsons

PCT/AU2001/000680

Therapeutic agents III Andreas Suhrbier; Peter Parsons

PCT/AU2001/000678

patents families managed by Qimr as trustee for the crc-Vaccine technology

Title Inventor(s) Application Number

T helper epitopes David Jackson PCT/AU2000/000070

Novel immunogenic lipopeptides comprising T-helper and cytotoxic T lymphocyte (CTL) epitope

David Jackson PCT/AU2003/001019

Novel immunogenic lipopeptides comprising T-helper and B-cell epitopes David Jackson PCT/AU2003/001018

Truncated LHRH formulations David Jackson PCT/AU2005/001383

Immunogenic molecules David Jackson PCT/AU2006/000162

trade marks managed by QimrMark Status Australian Trade Mark Number

Queensland Institute of Medical Research Registered / Protected 1233303

QIMR Registered / Protected 1233307

Hexagons device Registered / Protected 1233317


grantS anD funDing (over $100,000)

Source Chief Investigators and Project Title Term PeriodTotal

Funding

NHMRC Antonsson, A – Squamous cell carcinomas of the head and neck: Exploring the role of human papillomavirus infection

2yrs 2011 – 2012 $212,015

ALF McDonald, Cameron – Hospitality Industry Career Development Research Fellows

3yrs 2011 – 2013 $270,000

ARC Chong, Suyinn – Epigenetic neurobehavioral changes in new mouse models of foetal alcohol spectrum disorders

4yrs 2011 – 2014 $701,842

ARC Valery, Patricia – Developing an evidence base to improve the health Aboriginal and Torres Strait Islander people

4yrs 2011 – 2014 $568,352

ARC Lopez, Alejandro et al – Characterisation of the anti-inflammatory pathway targeted by chaperonin 10 (Administered by Griffith University)

4yrs 2010 – 2013 $530,000

ARC Martin, Nick – From genotype to phenotype: Molecular photo fitting for criminal investigations (Administered by University of Canberra)

3yrs 2011 – 2013 $245,358

ARC Kay, Graham and Hayward, Nick – Molecular characterization of the role of menin in embryonic development (Administered by The University of Queensland)

3yrs 2011 – 2013 $345,000

BUSHEL Subramaniam, Nathan – Hereditary haemochromatosis: Characterisation of the HepcidiAxia.

4yrs 2010 – 2013 $288,400

CA/NBCF MacGregor, Stuart – Identifying markers of risk and outcome in ovarian and breast cancer via efficient evaluation of DNA methylation

4yrs 2011 – 2014 $521,490

CANCERAU Spurdle, Amanda – Development of a model to classify mismatch repair 3yrs 2011 – 2013 $600,000

CCQ Boyd, Andrew – Suppression of high-grade glioma by Nfib over expression 2yrs 2011 – 2012 $146,500

CCQ Hayward, Nick – Identification of novel methylated tumour suppressor genes in melanoma

2yrs 2011 – 2012 $199,472

CCQ Hill, Geoff – Therapeutic targeting of adhesion and costimulatory pathways after transplantation

2yrs 2011 – 2012 $200,000

CCQ Khanna, Kum Kum – Understanding the contribution of DNA repair genes in breast metastasis

2yrs 2011 – 2012 $199,472

CCQ Khanna, Rajiv – Novel immunotherapy for herpes virus infection in stem cell transplant patients.

2yrs 2011 – 2012 $195,016

CCQ MacDonald, Kelli – Requirements for class II antigen presentation to generate curative anti-leukaemic responses

5yrs 2011 – 2015 $594,970

CCQ Walker, Graeme – Pilot study to assess the role of classical and oxidative UVR-induced DNA adducts in melanoma induction

2yrs 2011 – 2012 $200,000

CCQ Young, Joanne – Excome capture, miRNA and next generation sequencing inprobands with hyperplastic polyposis

2 yrs 2011 – 2012 $200,000

CSIRO Hurst, Tim – Urbanism, Climate Adaptation and Health Cluster (Flagship Cluster)

4yrs 2010 – 2013 $200,000

DEEDI Boyle, Glen – Smart Futures Commercialisation Program 3yrs 2010 – 2012 $107,048

ECO Boyle, Glen – Smart Futures Commercialisation Program 3yrs 2010 – 2012 $107,048

GARNETT Antonsson, Annika – Exploring the role of human papillomavirus infection in mucosal squamous cell carcinomas of the head and neck.

3yrs 2011 – 2013 $150,016

HEARTF McMillan, David – Grant in Aid Research Program 2yrs 2011 – 2012 $127,456

NHMRC Hill, Geoff – NHMRC Australia Fellowship (Jan 2011-Dec 2015) 5yrs 2011 – 2015 $4,000,000

NHMRC Parsons, Peter – Taking a cancer drug towards a clinical trial 3yrs 2011 – 2013 $254,584

NHMRC Jones, Malcom – Roles of annexins in schistosome surface homeostasis and host parasite interaction

3yrs 2011 – 2013 $295,866

NHMRC Beesley, Jonathan – The TERT locus as a susceptibility gene for ovarian and breast cancer: genetic and functional evaluation

3yrs 2011 – 2013 $382,524

NHMRC Burrows, Scott – The impact of micropolymorphism within the T cell receptor genes and their target antigenic peptides

3yrs 2011 – 2013 $352,524

NHMRC Chong, Suyinn – Epigenetic and neuribehavioural changes in a new mouse model of foetal alcohol spectrum disorder

3yrs 2011 – 2013 $701,732

NHMRC Harrich, David – An RNA element negatively regulates HIV-1 reverse transcription and inhibits proviral intergration

3yrs 2011 – 2013 $561,453

NHMRC Harrich, David – How does a host cell stimulatory factor stabilize the HIV-1 reverse transcription complex?

3yrs 2011 – 2013 $610,074

NHMRC Khanna, Rajiv – Prophylactic vaccine to prevent cytomegalovirus disease. 3yrs 2011 – 2013 $421,299

NHMRC MacDonald Kelli – The role of alloantigen presentation in transplantation 3yrs 2011 – 2013 $490,470

NHMRC McRea, Allan – Inheritance of DNA methylation state in humans 3yrs 2011 – 2013 $579,766

NHMRC Medland, Sarah – Genetic influences on the comorbidity between Attention Deficit Hyperactivity Disorder and substance use

2yrs 2011 – 2012 $238,978 $238,978 2yrs 2011 – 2012Medland, Sarah – Genetic influences on the comorbidity between Attention Deficit Hyperactivity Disorder and substance use

Page 129

Source Chief Investigators and Project Title Term PeriodTotal

Funding

NHMRC Ramm, Grant – Role of tissue ferritin as a proinflammatory mediator of hepatic stellate cell activation in heptic iron overload

3yrs 2011 – 2013 $555,048

NHMRC Spurdle, Amanda – Prediction, verification and clinical significance of splicing aberrations associated with BRAC1 and BRAC2 variants

3yrs 2011 – 2013 $553,390

NHMRC Tellam, Judith – Enhanced expression of Epstein-Barr virus nuclear antigen, EBNA1, as a target for T cell based immunotherapy for prevention of viral-associated diseases

3yrs 2011 – 2013 $344,208

NHMRC Valery, Patricia – A comparative study: Patterns of care, comorbidities and quality of life of Indigenous and non-Indigenous people with lung, head and neck, breast or gynaecological cancers

3yrs 2011 – 2013 $610,731

NHMRC Wray, Naomi – Better methods for individual risk prediction of complex traits in human populations

3yrs 2011 – 2013 $578,416

NHMRC Wright, Margaret – Genetics of brain structure and function 3yrs 2011 – 2013 $560,218

NHMRC Yang, Yurong – Does environmental change drive the spatiotemporal transmission dynamics of Echinococcus spp. in Ningxia, China?

3yrs 2011 – 2013 $632,128

NHMRC Duffy, David – Genetic epidemiology of complex disease 5yrs 2011 – 2015 $630,505

NHMRC Khanna, Rajiv – Immunobiology of herpes virus infections 5yrs 2011 – 2015 $780,805

NHMRC McManus, Don – Elimination of zoonotic schistosomiasis 5yrs 2011 – 2015 $855,805

NHMRC Harten, Sarah – A piggy-back screen for genes involved involved in cancer 4yrs 2011 – 2014 $290,032

NHMRC Markey, Kate – The immune system in graft-versus-host disease 4yrs 2011 – 2014 $145,016

NHMRC Wei, Ting – A Novel RNA repressor element regulates HIV-1 4yrs 2011 – 2014 $290,032

NHMRC Willis, Charlene – Haemolysines and haemoglobinases as anti-hookworm vaccines (Transferred from Griffith University)

2yrs 2011 – 2012 $122,875

NHMRC Webb, Penny – CARE Kidney Study (Administered by The University of Queensland)

3yrs 2011 – 2013 $245,275

NHMRC Hayward, Nick – Molecular determinants of risk, progression and treatment response in melanoma (Administered by University of Sydney)

5yrs 2011 – 2015 $1,608,665

NIH Martin, Nick – Genetic and environmental pathways to drug use, abuse and dependence (Administered by Virginia Commonwealth University – USA)

4yrs 2010 – 2013 $389,251

OHMR Hill, Geoff – Senior Clinical Research Fellowship 5yrs 2011 – 2015 $4,250,000

PCFA Boyd, Andrew – Express and Function of Eph and ephrin proteins in prostate cancer

2yrs 2011 – 2012 $250,000

RBWH Breakspear, Michael – Health Research Fellowship – Mental Health Research Division (Administered by RBWH)

5yrs 2011 – 2015 $375,000

ROTRF Gandhi, Maher – Post transplant lymph proliferative disorders: A lab based study within LS CT

2yrs 2011 – 2012 $206,653

ROTRF Khanna, Rajiv – MHC Class II all recognition by virus-specific CD*+ T cell 2yrs 2011 – 2012 $206,653

SMART Wykes, Michelle – A novel treatment to generate long-term protection against malaria

4yrs 2010 – 2013 $300,000

Legend

ALF Australian Liver Foundation

ARC Australian Research Council

BUSHEL Bushel Foundation

CA/NBCF Cancer Australia/National Breast Cancer Foundation

CANCERAU Cancer Australia


CSIRO Commonwealth Scientific and Industrial Research Organisation

DEEDI Dept of Employment, Economic Development and Innovation

ECO Ecobiotics

GARNETT Garnett Passe and Rodney Williams Memorial Foundation

HEARTF Heart Foundation


NIH National Institutes of Health


PCFA Prostate Cancer Foundation Australia

RBWH Royal Brisbane and Women’s Hospital

ROTRF Roche Organ Transplantation Research Foundation

SMART Smart State Futures Fellowship

grants and funding | continued


Qimr feLLoWSSir Macfarlane Burnet Dr Natth Bhamarapravati Dr Michael O’Rourke

Prof Ralph Doherty Dr Louis Miller Mr Michael Barry

Prof Frank Fenner Sir Eric Saint Prof Kay Ellem

Dr Eric French Dr Robert Shope Dr Ian Taylor

Sir Abraham Fryberg Sir Bruce Watson Prof Lawrie Powell

Dr Douglas Lee The Hon Mike Ahern Mr Tom Veivers

Ms Margaret Macgregor Dr Neville McCarthy Mr Phillip Desbrow (Deceased)

Dr Aubrey Pye Sir Gustav Nossal Prof William O’Sullivan

Mr William Reeves Dr E D O’Callaghan Dr Diana Cavaye (Deceased)

Mr John Sprent Prof Frank Schofield Sr Regis Mary Dunne

Mr Harry Standfast Sir Edward Stewart Mr Clive Berghofer

Mr George Taylor Prof Tao Yixun Prof Bryan Campbell

Mr John Tonge Dr Chamlong Harinasuta Mr Sam Coco

Dr Carleton Gajdusek Prof Chev Kidson Dr Peter Wills

Dr David Henderson Dr Peter Livingstone Prof John Kerr

Prof Owen Powell Dr Michael Alpers Mr Paul Wright

Prof Julie Saroso Mr Rod Wylie Mr David Lyons

Prof Edwin Westaway Prof Graham Mitchell Mr Ian Goddard

Prof Vincent Zigas Prof Mervyn Eadie Ms Helen Luckoff

Sir Anthony Epstein Prof Bryan Emmerson Mr John Garnsey (Deceased)

Dr Douglas Gordon Dr Ian Wilkey Prof Graham Brown

Dr Elizabeth Marks Prof Ted Brown Prof Robert MacLennan

Dr Neville Davis Prof Peter Doherty Prof Peter Brooks

Dr Robert Porter Prof Paul Korner Dr Peter Roeser

Prof Brian Wilson Dr Stephen Lynch

Page 131

oVerSeaS traVeLTravel by researchers and corporate staff is critical to facilitate collaborations and ensure the Institute keeps pace with new technologies and techniques. The following overseas travel was taken during the 2010–2011 financial year.

Name of Officer & Position Destination Reason for Travel Agency Cost ($)Contribution from other agencies or sources

Prof Frank Gannon (Director)

Europe EMBO/EMBC Conference 9,679

Prof Frank Gannon (Director)

Europe Invited Lecturer – Redfern Lecture at 50th Anniversary of the Dept of Biochemistry, Leicester; Speaker at meeting – “Starting from Transcription… Honneur a Pierre Chambon”, IGBMC; Meeting re. HIRF – Erlangen, Germany ; Attend the 36th FEBS Congress, Torino, Italy

13,881

University of Leicester $4,288

Dr Cameron McDonald (Research Officer)

Dr Deepak Darshan (Research Officer)

Assoc Prof Nathan Subramaniam (Lab Head)

Canada BioIron Conference 3,989

Dr Lutz Krause (Lab Head)

USA/Europe Attend the Human Micro biome Research Conference; FASEB Conference and ISMB Conference

8,991

Prof Nick Hayward (Lab Head)

Israel/UK International Melanoma Genetics Consortium (GenoMEL) Annual Conference – Israel : Meeting of BioGenoMEL Consortium (UK)

6,613 European Commission grant $4,613

Ms Michelle Richards (Safety Officer)

Canada Attend 2011 Annual International High Containment Bio-safety Workshop, International Centre for Infectious Diseases

3,523

Ms Grace Chojnowski (Scientific Technical Officer)

USA Attend CYTO2011 and ISAC Council Meeting 4,300

Dr Antiopi Varelias (Research Officer)

USA 98th Annual Meeting of the American Association of Immunologists

2,043

Dr Ingrid Rowlands (Research Officer)

UK Laboratory visit – National Perinatal Epidemiology Unit, Oxford

1,106

Mr Yi Chieh Lim (PhD Student)

USA Gordon Research Conference 1,875

Dr Rachel Neale (Senior Research Fellow)

Copenhagen/ Denmark

1st International Conference on UV and Skin Cancer Prevention

3,972 $2,672

Dr Alex Combes (Research Officer)

Germany Chromatin and Epigenetics Conference 3,505 $2,505

Dr Zhen Zhen Zhao (Senior Research Officer)

China Attend and present at Cold Harbor Springs Asia Meeting

2,500 $1,500

Dr Olivier Becherel (Senior Research Officer)

USA Keystone Symposia – Genomic Instability and DNA Repair

1,860


Scientific puBLicationSAbdel-Aal ABM, Zaman M, Fujita Y, Batzloff MR, Good MF, Toth I. Design of Three-Component Vaccines against Group A Streptococcal Infections: Importance of Spatial Arrangement of Vaccine Components. Journal of Medicinal Chemistry. 2010;53(22):8041-8046.

Ainger SA, Wong SS, Roberts DW, Leonard JH, Sturm RA. Effect of MC1R variant allele status on MSH-ligand induction of dopachrome tautomerase in melanocytes co-cultured with keratinocytes. Experimental Dermatology. 2011;20(8):681-684.

Al-Ejeh F, Kumar R, Wiegmans A, Lakhani SR, Brown MP, Khanna KK. Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene. 2010;29(46):6085-6098.

Al-Ejeh F, Smart CE, Morrison BJ, Chenevix-Trench G, Lopez JA, Lakhani SR, Brown MP, Khanna KK. Breast cancer stem cells: treatment resistance and therapeutic opportunities. Carcinogenesis. 2011;32(5):650-658.

Alford JR, Hatemi PK, Hibbing JR, Martin NG, Eaves LJ. The Politics of Mate Choice. Journal of Politics. 2011;73(2):362–379.

Allen HL, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segre AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Smith AV, Magi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Lo KS, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu JF, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry JRB, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Junttila MJ, Kaplan LM, Kettunen J, Konig IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon M, McKnight B, Morris AP, Muller M, Ngwa JS, Purcell S, Rafelt S, Salem RM, Salvi E, Sanna S, Shi JX, Sovio U, Thompson JR, Turchin MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A, Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJC, Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui JN, Igl W, Illig T, Jula A, Kajantie E, Kilpelaeinen TO, Koiranen M, Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu JJ, Lokki ML, Marusic A, Maschio A, Meitinger T, Mulas A, Pare G, Parker AN, Peden JF, Petersmann A, Pichler I, Pietilainen KH, Pouta A, Riddertrale M, Rotter JI, Sambrook JG, Sanders AR, Schmidt CO, Sinisalo J, Smit JH, Stringham HM, Walters GB, Widen E, Wild SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall M, McArdle WL, Nelis M, Peters MJ, Ripatti S, Meurs JBJ, Aben KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S, Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall AS, Hamsten A, Huikuri HV, Iribarren C, Kahonen M, Kaprio J, Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimaki T, Melander O, Mosley TH, Musk AW, Nieminen MS, O’Donnell CJ, Ohlsson C,

Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD, Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS, Stumvoll M, Tonjes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM, Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Gronberg H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Lathrop GM, Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL, Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Cupples LA, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW, Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD, Volzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB, Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter DJ, O’Connell JR, Strachan DP, Schadt HE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG, Visscher PM, Chatterjee N, Loos RJF, Boehnke M, McCarthy MI, Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM, Hirschhorn JN. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010;467(7317):832-838.

Allen KJ, Bertalli NA, Osborne NJ, Constantine CC, Delatycki MB, Nisselle AE, Nicoll AJ, Gertig DM, McLaren CE, Giles GG, Hopper JL, Anderson GJ, Olynyk JK, Powell LW, Gurrin LC. HFE Cys282Tyr Homozygotes With Serum Ferritin Concentrations Below 1000 mu g/L Are at Low Risk of Hemochromatosis. Hepatology. 2010;52(3):925-933.

Amankwah EK, Kelemen LE, Wang Q, Song H, Chenevix-Trench G; Australian Ovarian Cancer Study Group, Beesley J, Webb PM; Australian Cancer Study (Ovarian Cancer), Pearce CL, Wu AH, Pike MC, Stram DO, Chang-Claude J, Wang-Gohrke S, Ness RB, Goode EL, Cunningham JM, Fridley BL, Vierkant RA, Tworoger SS, Whittemore AS, McGuire V, Sieh W, Gayther SA, Gentry-Maharaj A, Menon U, Ramus SJ, Rossing MA, Doherty JA, Goodman MT, Carney ME, Lurie G, Wilkens LR, Kjær SK, Høgdall E, Cramer DW, Terry KL, Garcia-Closas M, Yang H, Lissowska J, Anton-Culver H, Ziogas A, Schildkraut JM, Berchuck A, Pharoah PD; Ovarian Cancer Association Consortium. Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer. Cancer Epidemiology Biomarkers & Prevention. 2011;20(5):1028-31.

Amankwah EK, Kelemen LE, Wang QG, Song HL, Chenevix-Trench G, Beesley J, Webb PM, Pearce CL, Wu ANH, Pike MC, Stram DO, Chang-Claude J, Wang-Gohrke S, Ness RB, Goode EL, Cunningham JM, Fridley BL, Vierkant RA, Tworoger SS, Whittemore AS, McGuire V, Sieh W, Gayther SA, Gentry-Maharaj A, Menon U, Ramus SJ, Rossing MA, Doherty JA, Goodman MT, Carney ME, Lurie G, Wilkens LR, Kjaer SK, Hogdall E, Cramer DW, Terry KL, Garcia-Closas M, Yang H, Lissowska J, Anton-Culver H, Ziogas A, Schildkraut JM, Berchuck A, Pharoah PDP. Prostate Cancer Susceptibility Polymorphism rs2660753 Is Not Associated with Invasive Ovarian Cancer. Cancer Epidemiology Biomarkers & Prevention. 2011;20(5):1028-1031.

Amankwah EK, Wang QG, Schildkraut JM, Tsai YY, Ramus SJ, Fridley BL, Beesley J, Johnatty SE, Webb PM, Chenevix-Trench G, Dale LC, Lambrechts D, Amant F, Despierre E, Vergote

I, Gayther SA, Gentry-Maharaj A, Menon U, Chang-Claude J, Wang-Gohrke S, Anton-Culver H, Ziogas A, Dork T, Durst M, Antonenkova N, Bogdanova N, Brown R, Flanagan JM, Kaye SB, Paul J, Butzow R, Nevanlinna H, Campbell I, Eccles DM, Karlan BY, Gross J, Walsh C, Pharoah PDP, Song HL, Kjaer SK, Hogdall E, Hogdall C, Lundvall L, Nedergaard L, Kiemeney LALM, Massuger LFAG, van Altena AM, Vermeulen SHHM, Le ND, Brooks-Wilson A, Cook LS, Phelan CM, Cunningham JM, Vachon CM, Vierkant RA, Iversen ES, Berchuck A, Goode EL, Sellers TA, Kelemen LE. Polymorphisms in Stromal Genes and Susceptibility to Serous Epithelial Ovarian Cancer: A Report from the Ovarian Cancer Association Consortium. PLoS ONE. 2011;6(5).

Amante FH, Engwerda CR, Good MF. Experimental asexual blood stage malaria immunity. Current Protocols in Immunology. 2011;Chapter19(Unit19.4).

Amante FH, Haque A, Stanley AC, Rivera FD, Randall LM, Wilson YA, Yeo G, Pieper C, Crabb BS, de Koning-Ward TF, Lundie RJ, Good MF, Pinzon-Charry A, Pearson MS, Duke MG, McManus DP, Loukas A, Hill GR, Engwerda CR. Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria. Journal of Immunology. 2010;185(6):3632-3642.

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Sunde L, Peterlongo P, Manoukian S, Bonanni B, Viel A, Radice P, Caldes T, de la Hoya M, Singer CF, Fink-Retter A, Greene MH, Mai PL, Loud JT, Guidugli L, Lindor NM, Hansen TVO, Nielsen FC, Blanco I, Lazaro C, Garber J, Ramus SJ, Gayther SA, Phelan C, Narod S, Szabo CI, Benitez J, Osorio A, Nevanlinna H, Heikkinen T, Caligo MA, Beattie MS, Hamann U, Godwin AK, Montagna M, Casella C, Neuhausen SL, Karlan BY, Tung N, Toland AE, Weitzel J, Olopade O, Simard J, Soucy P, Rubinstein WS, Arason A, Rennert G, Martin NG, Montgomery GW, Chang-Claude J, Flesch-Janys D, Brauch H, Severi G, Baglietto L, Cox A, Cross SS, Miron P, Gerty SM, Tapper W, Yannoukakos D, Fountzilas G, Fasching PA, Beckmann MW, Silva IDS, Peto J, Lambrechts D, Paridaens R, Rudiger T, Forsti A, Winqvist R, Pylkaas K, Diasio RB, Lee AM, Eckel-Passow J, Vachon C, Blows F, Driver K, Dunning A, Pharoah PPD, offit K, Pankratz VS, Hakonarson H, Chenevix-Trench G, Easton DF, Couch FJ. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nature Genetics. 2010;42(10):885.

Antonsson A, Green AC, Mallitt KA, O’Rourke PK, Pandeya N, Pawlita M, Waterboer T, Neale RE. Prevalence and stability of antibodies to 37 human papillomavirus types - A population-based longitudinal study. Virology. 2010;407(1):26-32.

Antonsson A, Green AC, Mallitt KA, O’Rourke PK, Pawlita M, Waterboer T, Neale RE. Prevalence and stability of antibodies to the BK and JC polyomaviruses: a long-term longitudinal study of Australians. Journal of General Virology. 2010;91(Part 7):1849-1853.

Antonsson A, Nancarrow DJ, Brown IS, Green AC, Drew PA, Watson DI, Hayward NK, Whiteman DC. High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma. Cancer Epidemiology Biomarkers & Prevention. 2010;19(8):2080-2087.

Antonsson A, Nancarrow DJ, Brown IS, Green AC, Drew PA, Watson DI, Hayward NK, Whiteman DC. High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma-Response. Cancer Epidemiology Biomarkers & Prevention. 2011;20(2):409-410.

Anttila V, Stefansson H, Kallela M, Todt U, Terwindt GM, Calafato MS, Nyholt DR, Dimas AS, Freilinger T, Muller-Myhsok B, Artto V, Inouye M, Alakurtti K, Kaunisto MA, Hamalainen E, de Vries B, Stam AH, Weller CM, Heinze A, Heinze-Kuhn K, Goebel I, Borck G, Gobel H, Steinberg S, Wolf C, Bjornsson A, Gudmundsson G, Kirchmann M, Hauge A, Werge T, Schoenen J, Eriksson JG, Hagen K, Stovner L, Wichmann E, Meitinger T, Alexander M, Moebus S, Schreiber S, Aulchenko YS, Breteler MMB, Uitterlinden AG, Hofman A, van Duijn CM, Tikka-Kleemola P, Vepsalainen, Lucae S, Tozzi F, Muglia P, Barrett J, Kaprio J, Farkkila M, Peltonen L, Stefansson K, Zwart JA, Ferrari MD, Olesen J, Daly M, Wessman M, van den Maagdenberg AMJM, Dichgans M, Kubisch C, Dermitzakis ET, Frants RR, Palotie A. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nature Genetics. 2010;42(10):869.

Ao A, Morrison BJ, Wang H, López JA, Reynolds BA, Lu J. Response of estrogen receptor-positive breast cancer tumorspheres to antiestrogen treatments. PLoS ONE. 2011;6(4):e18810.

Apte SH, Groves P, Olver S, Baz A, Doolan DL, Kelso A, Kienzle N. IFN-gamma Inhibits IL-4-Induced Type 2 Cytokine Expression by CD8 T Cells

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Asojo OA, Loukas A, Inan M, Barent R, Huang JC, Plantz B, Swanson A, Gouthro M, Meagher MM, Hotez PJ. Crystallization and preliminary X-ray analysis of Na-ASP-1, a multi-domain pathogenesis-related-1 protein from the human hookworm parasite Necator americanus. Acta Crystallographica Section F-Structural Biology and Crystallization Communications. 2010;66:1549-1549.

Aung HT, Harrison DK, Findlay I, Mattick JS, Martin NG, Carroll BJ. Stringent Programming of DNA Methylation in Humans. Twin Research and Human Genetics. 2010;13(5):405-411.

Baade PD, Youlden DR, Valery PC, Hassall T, Ward L, Green AC, Aitken JF. Population-based survival estimates for childhood cancer in Australia during the period 1997-2006. British Journal of Cancer. 2010;103(11):1663-1670.

Badrick AC, Jones CE. Reorganizing metals: the use of chelating compounds as potential therapies for metal-related neurodegenerative disease. Current Topics in Medicinal Chemistry. 2011;11(5):543-52.

Balen J, McManus DP, Li YS, Zhao ZY, Yuan LP, Utzinger J, Williams GM, Li Y, Ren MY, Liu ZC, Zhou J, Raso G. Comparison of two approaches for measuring household wealth via an asset-based index in rural and peri-urban settings of Hunan province, China. Emerging Themes in Epidemiology. 2010;7(1):7.

Barnett AG, Tong S, Clements ACA. What measure of temperature is the best predictor of mortality?. Environmental Research. 2010;110(6):604-611.

Barnett AG, Tong SL, Clements ACA. Reply to commentary “Time series analysis on the health effects of temperature: Two areas for future research” by Gasparrini and Armstrong. Environmental Research. 2010;110(6):639-639.

Bates TC, Lind PA, Luciano M, Montgomery GW, Martin NG, Wright MJ. Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation. Molecular Psychiatry. 2010;15(12):1190-1196.

Bates TC, Luciano M, Medland SE, Montgomery GW, Wright MJ, Martin NG. Genetic Variance in a Component of the Language Acquisition Device: ROBO1 Polymorphisms Associated with Phonological Buffer Deficits. Behavior Genetics. 2011;41(1):50-57.

Bates TC, Luciano M, Montgomery GW, Wright MJ, Martin NG. Genes for a component of the language acquisition mechanism: ROBO1 polymorphisms associated with phonological buffer deficits. Behavior Genetics. 2010;40(6):785-786.

Batra J, Nagle CM, O’Mara T, Higgins M, Dong Y, Tan OL, Lose F, Skeie LM, Srinivasan S, Bolton KL, Song H, Ramus SJ, Gayther SA, Pharoah PDP, Kedda MA, Spurdle AB, Clements JA. A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival. BMC Cancer. 2011;11(Art. 119).

Beadle G, Mengersen K, Moynihan S, Yates P. Perceptions of the ethical conduct of cancer trials by oncology nurses. European Journal of Cancer Care. 2011;1365-2354.

Beam CR, Horn EE, Hunt SK, Emery RE, Turkheimer E, Martin N. Revisiting the effect of marital support on depressive symptoms in mothers and fathers: A genetically informed study. Journal of Family Psychology. 2011;23(3):336–344.

Scientific publications | continued

H, Kirchhoff T, Vijai J, Gaudet MM, Altshuler D, Guiducci C, Loman N, Harbst K, Rantala J, Ehrencrona H, Gerdes AM, Thomassen M, D, Guiducci C, Loman N, Harbst K, Rantala J, Ehrencrona H, Gerdes AM, Thomassen M, J, Ehrencrona H, Gerdes AM, Thomassen M, Induced Type 2 Cytokine Expression by CD8 T Cells Induced Type 2 Cytokine Expression by CD8 T Cells

Apte SH, Groves P, Olver S, Baz A, Doolan DL, IFN-gamma Inhibits IL-4-

Induced Type 2 Cytokine Expression by CD8 T Cells Journal of Family Psychology.

of marital support on depressive symptoms in mothers and fathers: A genetically informed study. Journal of Family Psychology.Journal of Family Psychology. 2011;23(3):336–344.


Beaumont KA, Wong SS, Ainger SA, Liu YY, Patel MP, Millhauser GL, Smith JJ, Alewood PF, Leonard JH, Sturm RA. Melanocortin MC(1) receptor in human genetics and model systems. European Journal of Pharmacology. 2011;660(1):103-110.

Bedi S, Nelson EC, Lynskey MT, Mc Cutcheon VV, Heath AC, Madden PA, Martin NG. Risk for Suicidal Thoughts and Behavior after Childhood Sexual Abuse in Women and Men. Suicide & Life-Threatening Behavior. 2011. [Published online ahead of print].

Beesley J, Johnatty SE, Chen XQ, Spurdle AB, Peterlongo P, Barile M, Pensotti V, Manoukian S, Radice P, Chenevix-Trench G. No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women. Breast Cancer Research and Treatment. 2011;126(1):235-239.

Beesley VL, Clavarino AM, Webb PM, Wyld DK, Francesconi AB, Horwood KR, Doecke JD, Loos CA, Green AC. Ranked importance of outcomes of first-line versus repeated chemotherapy among ovarian cancer patients. Supportive Care in Cancer. 2010;18(8):943-949.

Beesley VL, Price MA, Butow PN, Green AC, Olsen CM, Webb PM; Australian Ovarian Cancer Study Group; Australian Ovarian Cancer Study Quality of Life Study Investigators. Physical activity in women with ovarian cancer and its association with decreased distress and improved quality of life. Psychooncology. 2010. [Published online ahead of print].

Beesley VL, Price MA, Webb PM, Australian Ovarian Cancer Study Group, Australian Ovarian Cancer Study Quality of Life Study Investigators. Loss of lifestyle: health behaviour and weight changes after becoming a caregiver of a family member diagnosed with ovarian cancer. Supportive Care In Cancer. 2010. [Published online ahead of print].

Benyamin B, Montgomery GW, Martin NG, Whitfield JB. Transferrin saturation and mortality. Clin Chem. 2011;57(6):921-3.

Berchuck A, Pharoah P, Ramus S, Gayther S, Palmieri R, Pearce C, Couch F, Antonio A, Goode E, Schildkraut J, Chenevix-Trench G, Sellers T, Risch H. Association of KRAS SNP rs61764370 with risk of invasive epithelial ovarian cancer: Implications for clinical testing. Gynecologic Oncology. 2011;121(2):S2-S3.

Bergen SE, Balhara YPS, Christoforou A, Cole J, Degenhardt F, Dempster E, Fatjo-Vilas M, Khedr Y, Lopez LM, Lysenko L, McGrath LM, Muhleisen TW, Neves FS, Nymberg C, Ozomaro U, Verweij KJH, Voineskos AN, Zai CC, O’Shea A, DeLisi LE. Summaries from the XVIII World Congress of Psychiatric Genetics, Athens, Greece, 3-7 October 2010. Psychiatric Genetics. 2011;21(3):136-172.

Berk M, Johansson S, Wray NR, Williams L, Olsson C, Haavik J, Bjerkeset O. Glutamate cysteine ligase (GCL) and self reported depression: An association study from the HUNT. Journal of Affective Disorders. 2011;131(1-3):207-213.

Blokland G, McMahon K, Thompson P, Martin N, de Zubicaray G, Wright MJ. Heritability of FMRI response in young adult twins. Behavior Genetics. 2010;40(6):787-787.

Bolton KL, Tyrer J, Song H, Ramus SJ, Notaridou M, Jones C, Sher T, Gentry-Maharaj A, Wozniak E, Tsai YY, Weidhaas J, Paik D, Van Den Berg DJ, Stram DO, Pearce CL, Wu AH, Brewster W, Anton-Culver H, Ziogas A, Narod SA, Levine DA, Kaye SB, Brown R, Paul J, Flanagan J, Sieh W, McGuire V, Whittemore AS,

Campbell I, Gore ME, Lissowska J, Yang HP, Medrek K, Gronwald J, Lubinski J, Jakubowska A, Le ND, Cook LS, Kelemen LE, Brook-Wilson A, Massuger LF, Kiemeney LA, Aben KK, van Altena AM, Houlston R, Tomlinson I, Palmieri RT, Moorman PG, Schildkraut J, Iversen ES, Phelan C, Vierkant RA, Cunningham JM, Goode EL, Fridley BL, Kruger-Kjaer S, Blaeker J, Hogdall E, Hogdall C, Gross J, Karlan BY, Ness RB, Edwards RP, Odunsi K, Moyisch KB, Baker JA, Modugno F, Heikkinenen T, Butzow R, Nevanlinna H, Leminen A, Bogdanova N, Antonenkova N, Doerk T, Hillemanns P, Dürst M, Runnebaum I, Thompson PJ, Carney ME, Goodman MT, Lurie G, Wang-Gohrke S, Hein R, Chang-Claude J, Rossing MA, Cushing-Haugen KL, Doherty J, Chen C, Rafnar T, Besenbacher S, Sulem P, Stefansson K, Birrer MJ, Terry KL, Hernandez D, Cramer DW, Vergote I, Amant F, Lambrechts D, Despierre E, Fasching PA, Beckmann MW, Thiel FC, Ekici AB, Chen X; Australian Ovarian Cancer Study Group; Australian Cancer Study (Ovarian Cancer); Ovarian Cancer Association Consortium, Johnatty SE, Webb PM, Beesley J, Chanock S, Garcia-Closas M, Sellers T, Easton DF, Berchuck A, Chenevix-Trench G, Pharoah PD, Gayther SA. Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nature Genetics. 2010;42(10):880-884.

Bond CE, Umapathy A, Buttenshaw RL, Leggett BA, Whitehall VLJ. BRAF, MSI and CIN-molecular determinants of outcome of the serrated pathway of colorectal cancer. Journal of Gastroenterology and Hepatology. 2010;25:A12.

Bond CE, Umapathy A, Ramsnes I, Greco SA, Zhao ZZ, Mallitt KA, Buttenshaw RL, Montgomery GW, Leggett BA, Whitehall VL. P53 mutation is common in microsatellite stable, BRAF mutant colorectal cancers. International Journal of Cancer. 2011. [Published online ahead of print].

Botelho NK, Schneiders FI, Lord SJ, Freeman AK, Tyagi S, Nancarrow DJ, Hayward NK, Whiteman DC, Lord RVN. Gene expression alterations in formalin-fixed, paraffin-embedded Barrett’s esophagus and esophageal adenocarcinoma tissues. Cancer Biology & Therapy. 2010;10(2):172-179.

Bouzigon E, Forabosco P, Koppelman GH, Cookson WOCM, Dizier M-H, Duffy DL, Evans DM, Ferreira MAR, Kere J, Laitinen T, Malerba G, Meyers DA, Moffatt M, Martin NG, Ng MY, Pignatti PF, Wjst M, Kauffmann F, Demenais F, Lewis CM. Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy. European Journal of Human Genetics. 2010;18(6):700-706.

Boyle GM, Woods SL, Bonazzi VF, Stark MS, Hacker E, Aoude LG, Dutton-Regester K, Cook AL, Sturm RA, Hayward NK. Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell & Melanoma Research. 2011;24(3):525-537.

Boyle GM. Therapy for metastatic melanoma: an overview and update. Expert Reviews of Anticancer Therapy. 2011;11(5):725-37.

Bradbury RS, Reid DW, Inglis TJ, Champion AC. Decreased virulence of cystic fibrosis Pseudomonas aeruginosa in Dictyostelium discoideum. Microbiology Immunology. 2011;55(4):224-30.

Bradbury RS, Roddam LF, Merritt A, Reid DW, Champion AC. Virulence gene distribution in clinical, nosocomial and environmental isolates of Pseudomonas aeruginosa. Journal of Medical Microbiology. 2010;59(pt8):881-90.

Bradbury RS, Tristram SG, Roddam LF, Reid DW, Inglis TJ, Champion AC. Antimicrobial

susceptibility testing of cystic fibrosis and non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa: a comparison of three methods. British Journal of Biomedical Science. 2011;68(1):1-4.

Branstrom R, Kasparian NA, Chang YM, Affleck P, Tibben A, Aspinwall LG, Azizi E, Baron-Epel O, Battistuzzi L, Bergman W, Bruno W, Chan M, Cuellar F, Debniak T, Pjanova D, Ertmanski S, Figl A, Gonzalez M, Hayward NK, Hocevar M, Kanetsky PA, Leachman SA, Heisele O, Palmer J, Peric B, Puig S, Schadendorf D, Gruis NA, Newton-Bishop J, Brandberg Y. Predictors of Sun Protection Behaviors and Severe Sunburn in an International Online Study. Cancer Epidemiology Biomarkers & Prevention. 2010;19(9):2199-2210.

Brant AM, Boomsma DI, Corley RP, DeFries JC, Haworth CMA, Hewitt JK, Martin NG, McGue M, Petrill SA, Plomin R, Wadsworth SJ, Wright MJ. Ability and heritability: investigating the continuous effect of IQ score on IQ etiology in multiple samples. Behavior Genetics. 2010;40(6):788-788.

Braskie MN, Jahanshad N, Stein JL, Barysheva M, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Common Alzheimer’s disease risk variant within the CLU gene affects white matter microstructure in young adults. Journal of Neuroscience. 2011;31(18):6764-6770

Breakspear M, Heitmann S, Daffertshofer A. Generative models of cortical oscillations: neurobiological implications of the Kuramoto model. Frontiers in Human Neuroscience. 2010;4:190.

Breakspear M, Jirsa V, Deco G. Computational models of the brain: From structure to function. Neuroimage. 2010;52(3):727-730.

Brennan PA, Hammen C, Sylvers P, Bor W, Najman J, Lind P, Montgomery G, Smith AK. Interactions between the COMT Val108/158Met polymorphism and maternal prenatal smoking predict aggressive behavior outcomes. Biological Psychology. 2011;87(1):99-105.

Buchanan DD, Sweet K, Drini M, Jenkins MA, Win AK, English DR, Walsh MD, Clendenning M, McKeone DM, Walters RJ, Roberts A, Pearson SA, Pavluk E, Hopper JL, Gattas MR, Goldblatt J, George J, Suthers GK, Phillips KD, Woodall S, Arnold J, Tucker K, Muir A, Field M, Greening S, Gallinger S, Perrier R, Baron JA, Potter JD, Haile R, Frankel W, de la Chapelle A, Macrae F, Rosty C, Walker NI, Parry S, Young JP. Risk Factors for Colorectal Cancer in Patients with Multiple Serrated Polyps: A Cross-Sectional Case Series from Genetics Clinics. PLoS ONE. 2010;5(7).

Burdon KP, Macgregor S, Hewitt AW, Sharma S, Chidlow G, Mills RA, Danoy P, Casson R, Viswanathan AC, Liu JZ, Landers J, Henders AK, Wood J, Souzeau E, Crawford A, Leo P, Wang JJ, Rochtchina E, Nyholt DR, Martin NG, Montgomery GW, Mitchell P, Brown MA, Mackey DA, Craig JE. Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. Nature Genetics. 2011;43(6):574-U110.

Burke ML, Mcmanus DP, Ramm GA, Duke M, Li Y, Jones MK, Gobert GN. Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasis. Journal of Gastroenterology and Hepatology. 2010;25:A11-A11.

Burrows SR, Moss DJ, Khanna R. Understanding human T-cell-mediated immunoregulation through herpesviruses. Immunology and Cell Biology. 2011;89(3):352-358.

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Lin D, Tian F, Wu H, Gao Y, Wu J, Zhang D, Ji M, McManus DP, Driguez HP, Wu G. Multiple vaccinations with UV-attenuated cercariae in pig enhance protective immunity against Schistosoma japonicum infection as compared to single vaccination. Parasites & Vectors. 2011;4(103).

Lindor NM, Rabe KG, Petersen GM, Chen H, Bapat B, Hopper J, Young J, Jenkins M, Potter J, Newcomb P, Templeton A, LeMarchand L, Grove J, Burgio MR, Haile R, Green J, Woods MO, Seminara D, Limburg PJ, Thibodeau SN. Parent of origin effects on age at colorectal cancer diagnosis. International Journal of Cancer. 2010;127(2):361-366.

Liu A, Menon S, Colson NJ, Quinlan S, Cox H, Peterson M, Tiang T, Haupt LM, Lea RA, Griffiths LR. Analysis of the MTHFR C677T variant with migraine phenotypes. BMC Research Notes. 2010;28(3):213.

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Locke S, Osborne M, O’Rourke P. Persistent fatigue in young athletes: measuring the clinical course and identifying variables affecting clinical recovery. Scandinavian Journal of Medicine & Science In Sports. 2011;21(1):90-97.

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compLiance cHeckLiStFA ACT Financial Accountability Act 2009 FPMS Financial and Performance Management Standard 2009 ARRs Annual Report Requirements for Queensland Government Agencies

Summary of requirement Basis for requirementAnnual report reference

Accessibility Table of contents Glossary/Acronyms

ARRs – section 8.1 Page 1

Public availability ARRs – section 8.2 Inside front cover

Interpreter service statement Queensland Government Language Services Policy Inside front cover

Copyright notice Copyright Act 1968 Inside front cover

Letter of compliance

A letter of compliance from the accountable officer or statutory body to the relevant Minister(s)

ARRs – section 9 Page 2

Introductory information

Agency role and main functions ARRs – section 10.3 Page 16

Operating environment ARRs – section 10.3 Page 17

External scrutiny ARRs – section 10.3 Page 26

Machinery of government changes ARRs – section 10.3 Page 17

Review of proposed forward operations ARRs – section 10.3 Page 18

Non-financial performance

Government objectives for the community ARRs – section 11.2 Page 17

Agency objectives and performance indicators ARRs – section 11.5 Page 18

Agency outputs and output performance measures ARRs – section 11.6 Page 18

Financial performance

Summary of financial performance ARRs – section 12.1 Page 73

Disclosure of budget v actual results ARRs – section 12.2 N/A

Chief Finance Officer (CFO) statement ARRs – section 12.3 N/A

Governance – management and structure

Organisational structure ARRs – section 13.1 Page 20

Executive management ARRs – section 13.2 Page 27

Related entities ARRs – section 13.3 Page 40

Schedule of statutory authorities or instrumentalities ARRs – section 13.4 N/A

Boards and committees ARRs – section 13.5 Page 25

Public Sector Ethics Act 1994 - implementation statement giving details of the action taken during the reporting period

Public Sector Ethics Act 1994 (section 23 and Schedule)

Page 19

Whistleblowers Protection Act 1994 - public interest disclosures received

Whistleblowers Protection Act 1994 (sections 30 – 31 and Schedule)

Page 26


Summary of requirement Basis for requirementAnnual report reference

Governance – risk management and accountability

Risk management ARRs – section 14.1 Page 25

Audit committee ARRs – section 14.2 Page 26

Internal Audit ARRs – section 14.3 Page 26

Governance – human resources

Workforce planning, attraction and retention ARRs – section 15.1 Page 19

Early retirement, redundancy and retrenchment Directive No.17/09 Early Retirement, Redundancy and Retrenchment

N/A

Initiatives for women ARRs – section 15.1 and 15.3 N/A

Governance – operations

Consultancies ARRs – section 16.1 Page 73

Overseas travel ARRs – section 16.2 Page 132

Information systems and recordkeeping Public Records Act 2002 Page 26

Waste management Environmental Protection (Waste Management) Policy 2000, Environmental Protection Act 1994

N/A

Other prescribed requirements

Indigenous matters (Queensland Government Reconciliation Action Plan 2009–2012)

Queensland Government Reconciliation Action Plan 2009–2012

N/A

Shared services ARRs – section 17.1 N/A

Carbon emissions Premier’s Statement N/A

Optional information that may be reported

Corrections to previous annual reports ARRs – section 18.2 N/A

Right to Information Right to Information Act 2009 N/A

Information Privacy Information Privacy Act 2009 N/A

Native title N/A N/A

Financial statements

Annual general purpose financial statements Financial Reporting Requirements for Queensland Government Agencies

Page 74

Certification of financial statements FA Act – section 62 FPMS – sections 42, 43 and 50

Page 107

Independent Auditors Report FA Act – section 62 FPMS – section 50

Page 108

Remuneration disclosures Financial Reporting Requirements for Queensland Government Agencies

Page 101

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AnnuAl RepoRt - Queensland Parliament

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