Disampaikan oleh

Rini Ambarwati

ADH dan OXYTOCIN

Pituitary (Hypophysis)

Anterior Pituitary (pars distalis)=

ADENOHYPOPHYSIS

Posterior Pituitary (pars nervosa)=

NEUROHYPOPHYSIS

Hypothalamic Control of Posterior Pituitary

(ADH)

(Oxy)

A.D.A.M

Supraopticnucleus ADH +1/6 oxytocin

Paraventricular nucleusOxytocin + 1/6 ADH

ADH activates (2) second messenger systems:

1. cAMP

2. IP3/Ca2+

Fig. 45-15

Posteriorpituitary

Anteriorpituitary

Neurosecretorycells of thehypothalamus

Hypothalamus

Axon

HORMONE OxytocinADH

Kidney tubulesTARGET Mammary glands,uterine muscles

Struktur Kimia

Kerja ADH : 1. Reabsorbsi air

ADH

• Distal Tubule Permeabilitas • CollectingTubule air • Collecting duct

Reabsorbsi air(ECF di tub.ginjal >hipertonik)

Produksi urine berkurang

2. Pressor effect

Vasopressin/ADH

Vasokonstriksi Reabsorbsi di ginjal

arteri

Tekanan arteri volume darah

Angiotensin II ADH Increased

BloodPressure

Pengaturan Sekresi ADHPENINGKATAN ADH PENURUNAN ADH

OSMOLARITAS PLASMA OSMOLARITAS PLASMA

VOLUME DARAH VOLUME DARAH

TEKANAN DARAH TEKANAN DARAH

NAUSEA

HIPOKSIA

OBAT : OBAT :

MORFIN ALKOHOL

NIKOTINO KLONIDIN (OAH)

SIKLOFOSFAMID HALOPERIDOL ( PENGHAMBAT DOP.)

GUYTON & HALL 2007

SISTEM UMPAN BALIK OSMORESEPTOR - ADH

GUYTON & HALL 2007

Tekanan di atrium rendahBaroreseptor Sinus caroticus

Stretch reseptor di atrium Pulmonal Relaksasi Aorta

TEKANAN DARAH YANG RENDAH

SEKRESI ADH

Regulation of ADH

• Dehydration–ADH released

• Overhydration–ADH inhibited

Abnormalities of ADH release – Hyposecretion:

Diabetes Insipidus.

2 type DI : a. Neurogenic (central, or cranial) … Problem pada Hypothalamus or Post pituitary gland kegagalan memproduksi ADH b. Nephrogenic … Ketidakmampuan ginjal berespon terhadap ADH

pada duktus koligentes

Gejala : Polyurea 20 L/day (N 1.5 L/d), Polydepsia, diluted urine, plasma osmolality

Abnormalities of ADH release – Hypersecretion:

ADH, ‘Schwartz-Bartter Syndrome’: - Adenoma, ectopic kidney. - Bronchial carcinoma.

Signs & Symptoms:

- Hyponatremia, i.e. [Na+] extracellularly to 110 mM. (N = 140 mM); resulting in: - Mental confusion. - Coma. - Death, due to ventricular fibrillation.

Oxytocin

PROLACTIN

OXYTOCIN

Kerja Oksitosin

• Menyebabkan kontraksi uterus ibu hamil

• Membantu proses Laktasi

Kontraksi sel mioepitelpengaliran ASI (Milk letdown)

Pengaturan Oksitosin

1. Stimulation of nipple (suckling reflex) oxytocin.

2. Visual or auditory stimuli from the baby oxytocin secretion.

3. Distension of uterus & stretching of cervix during delivery oxytocin release.

4. Psychological & emotional factors, e.g. Fear, anxiety & pain oxytocin.

5. Alcohol oxytocin secretion.

6. Hormones:

a. progesterone uterine sensitivity to oxytocin.

b. estrogen uterine sensitivity to oxytocin.

Terima kasih