Terbinafine
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Reactions 1449 - 27 Apr 2013 Terbinafine Taste loss: 2 case reports Two patients developed taste loss while receiving terbinafine. A 61-year-old man presented with a 1-week history of loss of bitter and sour taste sensation. Examination also revealed partial loss of sweet and salty sensation. He had been receiving oral terbinafine [dosage not stated] for onychomycosis for the previous 36 days. Terbinafine was withdrawn. His taste function completely recovered after 2 months. A 47-year-old woman had a Trichophyton rubrum infection of the fingernails. She began receiving oral terbinafine 250mg daily, and was followed at a 2-week interval. At her second follow-up, she reported lost of interest in eating food. Her taste of spicy food was impaired, and she required more sugar and salt. Examination revealed loss of bitter and sour taste sensation, with partial loss of salty and sweet sensation. Terbinafine was withdrawn. Four weeks later, her taste sensation had completely recovered. Author comment: "Temporal association of taste loss 4–6 weeks after starting terbinafine and recovery after stopping the drug proved terbinafine as cause of taste loss in both these patients." Sinha R, et al. Terbinafine-induced taste impairment - report of two cases. Journal of Pakistan Association of Dermatologists 22: 363-365, No. 4, Oct-Dec 2012. Available from: URL: http://www.jpad.org.pk/Issue-Oct-Dec-2012.asp - India 803086200 1 Reactions 27 Apr 2013 No. 1449 0114-9954/10/1449-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Terbinafine
Reactions 1449 - 27 Apr 2013
Terbinafine
Taste loss: 2 case reportsTwo patients developed taste loss while receiving
terbinafine.A 61-year-old man presented with a 1-week history of loss
of bitter and sour taste sensation. Examination also revealedpartial loss of sweet and salty sensation. He had been receivingoral terbinafine [dosage not stated] for onychomycosis for theprevious 36 days. Terbinafine was withdrawn. His tastefunction completely recovered after 2 months.
A 47-year-old woman had a Trichophyton rubrum infectionof the fingernails. She began receiving oral terbinafine 250mgdaily, and was followed at a 2-week interval. At her secondfollow-up, she reported lost of interest in eating food. Her tasteof spicy food was impaired, and she required more sugar andsalt. Examination revealed loss of bitter and sour tastesensation, with partial loss of salty and sweet sensation.Terbinafine was withdrawn. Four weeks later, her tastesensation had completely recovered.
Author comment: "Temporal association of taste loss4–6 weeks after starting terbinafine and recovery afterstopping the drug proved terbinafine as cause of taste loss inboth these patients."Sinha R, et al. Terbinafine-induced taste impairment - report of two cases. Journalof Pakistan Association of Dermatologists 22: 363-365, No. 4, Oct-Dec 2012.Available from: URL: http://www.jpad.org.pk/Issue-Oct-Dec-2012.asp -India 803086200
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Reactions 27 Apr 2013 No. 14490114-9954/10/1449-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
