Ca endometrium grade III + HN ringan (s) + BSC + riwayat

operasi kista + anemiaStase Obgyn Ruang Cendrawasih

Identitas pasien• Nama : Ny.Kipxxxxx• Umur : 50 tahun• Alamat : KMP Barat Leke 1/6 Bangkalan• Tgl MRS : 8 Maret 2016• Alasan MRS : px kiriman POSA dengan ca endometrium gr.III + HN

ringan (s) + BSC + riwayat operasi • Status pasien : JKN

Riwayat Perjalanan Singkat Pasien

Patofisiologi Ca Endometrium

MOLECULAR PATHOGENESIS

Bansal et al. 2009

Features TYPE 1 TYPE 2

Estrogen associated Yes No

Hormone receptors ER/PR+ ER/PR-

Background endometrium Hyperplasia Atrophy

Tumour grade Low High

Myometrial invasion Superficial Deep

Clinical behaviour Indolent Aggressive

Mean age / diagnosis

61.9-63.7 years(pre- & perimenopausal)

66.8-69.3 years (serous)64.1-66.4 years (clear cell)

(postmenopausal)

Diagnosis Early stage (FIGO I/II) 86% Late stage (FIGO III/IV)41% (serious) & 33% (clear cell)

Prognosis

More favourable5 year survival by FIGO stage :

I 90%II 80%III 68%IV 26%

Poor5 year survival by FIGO stage :I 80% (serous), 85% (clear cell)II 41% (serous), 63% (clear cell)III 38% (serous), 49% (clear cell)IV 8% (serous), 6% (clear cell)

TYPE 1 VS TYPE 2 Weigelt, Britta. 2014

HISTOLOGICAL CLASSIFICATION

TYPE 1

TYPE 2

Lomo & Hecht. 2015

Stage Ia* Tumor limited to the endometrium Stage Ib* Invasion to less than half of the myometrium Stage Ic* Invasion equal to or more than half of the myometrium

STAGING

Stage IIa* Endocervical glandular involvement only

Stage IIb* Cervical stromal invasion