Nama : Pamor Faizal GhaniNPM : 1102014208Kelompok : B12Skenario Seorang ibu datang ke RS Pendidikan YARSI untuk berkonsultasi dengan seorang dokter spesialis penyakit dalam. Ibu tersebut mengeluhkan benjolan seperti gondok yang muncul di lehernya. Benjolan tersebut lunak, tidak nyeri, namun mengganggu. Dokter memvonis bahwa itu adalah kelenjar tiroid yang membengkak, namun ditemukan sel kanker yang jinak. Dokter mengatakan bahwa ibu tersebut kekurangan yodium. Dokter menyarankan untuk operasi pengambilan kelenjar tiroid yang mengandung sel kanker, lalu ibu tersebut mengatakan bahwa ekstrak kulit manggis dapat mencegah sel kanker.

Pertanyaan klinis (foreground question) :1. Apakah kandungan dalam kulit manggis efektif mencegah sel kanker datang kembali?

P (patient/problem) : kelenjar tiroid yang membengkak dan mengandung sel kankerI (indicator) : operasi lalu mengonsumsi ekstrak kulit manggisC (comparison) : operasi tanpa mengonsumsi ekstrak kulit manggisO (outcome) : sel kanker tidak muncul lagi

PICO : Seorang ibu mengalami pembengkakan kelenjar tiroid yang mengandung sel kanker disarankan dokter untuk operasi, lalu ibu tersebut menanyakan apakah ekstrak kulit manggis efektif untuk mencegah sel kanker.

Kata kunci : Anticancer AND mangosteen skin extract

Pemilihan situs : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635669/

Limitation :Summary, 20 per page, sorted by Journal

Hasil pencarian : 22

1. The Role and Place of Medicinal Plants in the Strategies for Disease Prevention

2. Natural Products as Aromatase Inhibitors

3. Altered mRNA Expression Related to the Apoptotic Effect of Three Xanthones on Human Melanoma SK-MEL-28 Cell Line

4. Antibacterial, antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel methanolicextract

5. Lupeol, A Novel Anti-inflammatory and Anti-cancer Dietary Triterpene

6. Gambogic Acid Inhibits STAT3 Phosphorylation Through Activation of Protein Tyrosine Phosphatase SHP-1: Potential Role in Proliferation and Apoptosis

7. Xanthones fromMangosteenExtracts as Natural Chemopreventive Agents: PotentialAnticancerDrugs

8. In VitroScreening of 10 Edible Thai Plants for Potential Antifungal Properties

9. Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells

10. Polyphenols from themangosteen(Garcinia mangostana) fruit for breast and prostate cancer

11. Anti-Cancer Effects of Xanthones from Pericarps ofMangosteen

12. Cellular trafficking andanticanceractivity ofGarcinia mangostanaextract-encapsulated polymeric nanoparticles

13. Emerging role of Garcinol, the antioxidant chalcone fromGarciniaindicaChoisy and its synthetic analogs

14. Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism

15. Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones fromMangosteen(Garcinia mangostana), a Popular Botanical Dietary Supplement

16. Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

17. Hydroxybenzoic acid isomers and the cardiovascular system

18. Antiviral Effects of BlackberryExtractAgainst Herpes Simplex Virus Type 1

19. Cancer is a Preventable Disease that Requires Major Lifestyle Changes

20. In VitroScreening for the Tumoricidal Properties of International Medicinal Herbs

21. Growth Inhibition of Human Gynecologic and Colon Cancer Cells byPhyllanthus watsoniithrough Apoptosis Induction

22. Effects of -mangostin on apoptosis induction of human colon cancer

Artikel yang dipilih : Gongbo Li, Stacey Thomas, Jeremy J. Johnson. Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer. Front Pharmacol. 2013; 4: 80.