Kuliah Blok Hemaologi-ERITROSIT

8/20/2019 Kuliah Blok Hemaologi-ERITROSIT

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RED BLOOD

CELL

RATNA KUSUMAWATI


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KORPUSKULER :

SEL-SEL DARAH

PLASMA DARAH

DARAH

ERITROSITLEUKOSIT

TROMBOSIT

8 % dari

BERAT TUBUH


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Sel-sel Darah


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Biconcave disk increase efficiency of ase!chane

Un"clea#ed don$# have D%A "nai&le#o re'air da(ae

)le!i&le #hro"h ca'illary syse(

*olor H&Per(ea&le #o +a#er, ion %a, *l K

./0 days des#royed &y RES


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FUNCTION OF RED BLOODCELL

1. Transport of O₂

- from lung to tissue !" #epen#ent$

%. Transport of CO₂- from tissue to lung #epen#s on&ar"oni& an'i#rase en()me * !"$

+. ,&i#-"ase "alan&e- t'roug' formation of "i&ar"onat!CO


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SEL STEM HEMOPOIETIK

PROERITROBLAS

ERITROSIT

OKSIGENASI JARINGAN

ERITROPOIETIN

GINJAL

MENURUN

1. Volu! dara" r!#da"$. A#!ia. H!o&lo'i# r!#da"(. Alira# dara" )!l!* +. P!#,a*i- aru


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• Penurunan transportasi jumlah O2 ke jaringanapa pun se!a!n"a# merangsang sumsumtulang utk mempro$uksi eritrosit

E! :

REGULASI PRODUKSI ERITROSIT

OKSIGENASI JARINGAN

/Pada ora#& a#!ia

/S!/!ora#& ada -!a- d*!-i#&&ia# ,& *adar O$ /a#&a- r!#d/Ga&al )a#-u#&/P!#,a*i- aru0 dll


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• Mer"'akan fak#or "#a(a y (eransan'rod"ksi eri#rosi#

• S"a#" hor(on liko'ro#ein y di&en#"k dl(

in1al 2#er"#a(a3 ha#i• Bila eri#ro'oie#in #dk ada, (aka hi'oksia

#dk4sediki# &er'enar"h dala( 'eransananeri#rosi#

• Se&aliknya, 1ika sis#e( eri#ro'oie#in&erf"nsi, (aka hi'oksia akan (eninka#kaneri#ro'oi#ein eri#ro'oi#ein akan(eninka#kan 'rod"ksi eri#rosi#

ERITROPOIETIN


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5ario"s o#her fac#ors can affec# #he ra#e ofery#hro'oiesis &y infl"encin ery#hro'oie#in

'rod"c#ion :• 6hyroid hor(ones, #hyroid-s#i("la#inhor(one, adrenal cor#ical s#eroids,adrenocor#ico#ro'hic hor(one, and h"(anro+#h hor(one 2H7H3 all 'ro(o#e

ery#hro'oie#in for(a#ion and so enhance red&lood cell for(a#ion 2ery#hro'oiesis38• Androens s#i("la#e and oes#roens de'ress

#he ery#hro'oie#ic res'onse8 9n addi#ion #o

#he effec#s of (ens#r"al &lood loss, #hiseffec# (ay e!'lain +hy +o(en #end #o havea lo+er hae(olo&in concen#ra#ion and redcell co"n# #han (en8


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• &er'eran adl 5i# B ./ Asa( fola#

• 5i# B./ Asa( fola# 'en#in "#k sin#esis D%A

K!*ura#&a# Vi- B1$ A/.2ola- P!#uru#a# DNA

K!&a&ala# !a-a#&a# !'!la"a# i#-i

S!l$ !ri-ro'la/-i* &a&al roli2!ra/i d 3!a-

MAKROSIT


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oli3i-!ia

0era

/!*u#d!r

2ailial


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I% 2 suksinil&KoA ' 2 glisin pirolII% (pirol protopor)irin I*

III% Protopor)irin I* ' heme

I+% Heme ' polipepti$a rantai hemoglo!in #an 2$

+% 2rantai 3 % rantai 2 hemoglo!in A

H! , 2 3 %4 Pa$a PaO2 tertentu- H!,mampu mengikat O2 le!ih !an"ak

++

Fe

GLOBIN S4NTHESIS


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• Di #alam nu5leus DN, mRN, trans5ripsi

$• mRN, masu5 sitoplasma teri5at #i ri"osom translasi sintesis rantai glo"in$

• 6lo"in 7 rantai polipepti#a

• Cluster gen glo"in alfa t#p #i 5romosom 11

• Cluster gen glo"in "eta t#p #i 5romosom 18

GLOBIN S4NTHESIS


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Kuliah Blok Hemaologi-ERITROSIT

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