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Research ArticleFORMULATION AND EVALUATION OF TOPICAL DICLOFENAC SODIUM GEL USING DIFFERENT

GELLING AGENT

Y. S. TANWAR1, AMIT KUMAR JAIN*2

For Author affiliations see end of the textThis paper is available olie at !!!."prhc.i

ABSTRACT:

The preset research has bee #$erta%e !ith the ai& to $evelop a topical 'el (orlatio o( )iclo(eac so$i#& #si'

$i((eret 'elli' a'et carbopol, Na M, +M -KM/ a$ so$i#& al'iate i $i((eret cocetratio, !hich !o#l$atte#ate the 'astroitestial relater to0icities associate$ !ith oral a$&iistratio. The !ere eval#ate$ (or phsicoche&icalproperties s#ch as ho&o'eeit, 'rittiess, viscosit, p+, Sprea$abilit, $r#' cotet, s%i irritac, in vitro $r#' release,

stabilit st#$ies. The in vitro drug release rate o( 'el !as eval#ate$ #si' ra3 $i((#sio cell cotaii' cellophae

&e&brae !ith phosphate b#((er p+ 4.5 as the receptor &e$i#&. St#$ies sho!e$ that $r#' release !as $ecrease !ithicrease i 'elli' a'et cocetratio beca#se pol&er cocetratio icreases, viscosit icreases. )r#' !as absorbe$(ro& site o( applicatio as lo' as it re&ais i hi'her cocetratio 'elli' a'et i sol#tio (or&.

Keywords: )iclo(eac So$i#&, carbopol, h$ro0l propl &ethl cell#lose, so$i#& al'iate atii(la&&ator activit.

INTRODUCTION

)iclo(eac So$i#& is a potet &e&ber o( the osteroi$al ati6i(la&&ator $r#'s -NSAI)s/, !i$el #se$ beca#se o( itsstro' aal'esic, atipretic a$ ati6i(la&&ator e((ects -162/.

7ral $ose o( $iclo(eac potassi#& ca#ses a icrease$ ris% o( serio#s 'astroitestial a$verse evets icl#$i'

blee$i', #lceratio a$ per(oratio o( the sto&ach or the itesties !hich co#l$ be (atal. )#e to the presece o( these oral

a$verse e((ects ecessitate the ee$ (or ivesti'ati' other ro#te o( $r#' $eliver o( $iclo(eac potassi#&. Tras$er&al$eliver o( the $r#' ca i&prove its bioactivit !ith re$#ctio o( the si$e e((ects a$ ehace the therape#tic e((icac -86/.

)eliver o( $r#'s to the s%i is a e((ective a$ tar'ete$ therap (or local $er&atolo'ical $isor$ers. This ro#te o($r#' $eliver has 'aie$ pop#larit beca#se it avoi$s (irst pass e((ects, 'astroitestial irritatio, a$ &etabolic $e'ra$atio

associate$ !ith oral a$&iistratio -964/. Topical 'el (orlatios provi$e a s#itable $eliver sste& (or $r#'s beca#se theare thi0otropic, 'reaseless, easil sprea$able, easil re&ovable, e&olliet, ostai', co&patible !ith several e0cipiets a$!ater6sol#ble or &iscible. erc#taeo#s absorptio o( $r#'s (ro& topical (orlatios ivolves the release o( the $r#' (ro&the (orlatio a$ per&eatio thro#'h s%i to reach the tar'et tiss#e. The release o( the $r#' (ro& topical preparatios

$epe$s o the phsicoche&ical properties o( the vehicle a$ the $r#' e&ploe$. -:6;/

S%i is oe o( the &ost rea$il accessible or'as o( h#&a bo$ (or topical a$&iistratio a$ &ai ro#te o(topical $r#' $eliver sste&. N#&bers o( &e$icate$ pro$#cts are applie$ to the s%i or co#s &e&brae that eitherehace or restore a (#$a&etal (#ctio o( a s%i or phar&acolo'icall alter a actio i the #$erlie$ tiss#es. -1

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Hiscosit icrease$ -(ro& 2;8

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NE8

>0cellet , ?oo$ , Satis(actor , No 'rittiess

Ta+%e 1: C*)*%a!9e Dr*$ re%ease #ro) $e% #or)*%a!o"s a d!##ere" !)e !"er9a%s

For)*%a!o" C*)*%a!9e

Re%eased !" 48

)!"

C*)*%a!9e

Re%eased !" -.8

)!"

C*)*%a!9e

Re%eased !" 148

)!"F- 1

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i'#re 8= #lative )r#' release (ro& +M 'el (orlatios at $i((eret ti&e itervals

i'#re = #lative )r#' release (ro& So$i#& Al'iate 'el (orlatios at $i((eret ti&e itervals

CONCLUSION

)iclo(eac so$i#& is a o6steroi$al atii(la&&ator $r#' -NSAI)/ that e0hibits atii(la&&ator, aal'esic, a$

atipretic activities. To overco&e the si$e e((ects associate$ !ith oral $iclo(eac so$i#& therap a$ to have the bee(its

associate$ !ith topical therap $iclo(eac so$i#& topical 'els are prepare$ i this st#$.St#$ies sho!e$ that $r#' release !as $ecrease !ith icrease i 'elli' a'et cocetratio beca#se pol&er cocetratio

icreases, viscosit icreases. )r#' !as absorbe$ (ro& site o( applicatio as lo' as it re&ais i hi'her cocetratio'elli' a'et i sol#tio (or&. So !ith a itetio to %eep the $iclo(eac so$i#& i sol#tio (or&, a$ th#s prolo'i' theti&e o( absorptio, 'el (orlatios !ere prepare$.

A',"ow%ed$e)e"s

The a#thors are tha%(#l to Mahat&a ?a$hi olle'e o( har&ace#tical Scieces (or provi$i' (acilities.

REFERENCES

1. Saa H, eaa TA, Moretti )FM. >((ect o( vehicle o $iclo(eac so$i#& per&eatio (ro& e! topical(orlatios= I vitro a$ I vivo st#$ies.#rret )r#' )eliver. 2

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9. Ki%!ai F, Dab# RJ, ra$o RA, et al. I vitro a$ I vivo eval#atio o( topical (orlatios o( spati$e II. AAShar&. Sci Tech. 2