DAFTAR ISIHalamanHALAMAN JUDUL...............................................................................................iHALAMAN PENGESEAHAN............................................................................. iiSURAT PERNYATAAN...................................................................................... iiiSURAT PERSETUJUAN PUBLIKASI............................................................. ivABSTRAK............................................................................................................. vABSTRACT.......................................................................................................... viKATA PENGANTAR......................................................................................... viiDAFTAR ISI......................................................................................................... viiiDAFTAR SINGKATAN...................................................................................... xiiDAFTAR TABEL................................................................................................. xivDAFTAR GAMBAR............................................................................................ xvDAFTAR GRAFIK.............................................................................................. xviDAFTAR LAMPIRAN........................................................................................ xviiBAB I.PENDAHULUAN............................................................... 11.1 Latar Belakang....................................................................... 11.2 Rumusan Masalah.................................................................. 21.3 Tujuan Penelitian.................................................................... 41. Tujuan Umum................................................................... 42. Tujuan Khusus.................................................................. 41.4 Manfaat Penelitian.................................................................. 51. Bidang Akademik............................................................. 52. Bidang Pengabdian Masyarakat........................................ 5BAB II.TINJAUAN PUSTAKA...................................................... 62.1 Kanker Kolorektal................................................................... 62.1.1 Definisi Kanker Kolorektal...................................... 62.1.2Epidemiologi ............................................................ 62.1.3Anatomi Kolon dan Rektum.................................... 72.1.4Fisiologi Kolon dan Rektum...................................... 92.1.5Klasifikasi................................................................... 102.1.6Faktor Resiko.............................................................. 122.1.6.1Polip................................................................ 122.1.6.2 Idiopathic Inflammatory Bowel Disease......... 122.1.6.3 Faktor Genetik................................................ 132.1.6.4 Diet................................................................. 142.1.6.5 Gaya Hidup.................................................... 152.1.6.6 Usia................................................................ 152.1.7Patofisiologi............................................................... 172.1.8 Gambaran Klinis........................................................ 202.1.8.1 Karsinoma Kolon Kanan............................... 202.1.8.2 Karsinoma Kolon Kiri dan Rektum.............. 202.1.8.3 Karsinoma Rektum........................................ 212.1.9Pemeriksaan Penunjang............................................. 212.1.9.1 Enema Barium Dengan Kontras Ganda........ 212.1.9.2 Endoskopi...................................................... 222.1.9.3 Pneumocolon Computed Tomography (PCT).. 222.1.10Diagnosis................................................................... 232.1.10.1 Anamnesis................................................... 232.1.10.2 Pemeriksaan Jasmani/Fisik.......................... 232.1.10.3 Pemeriksaan Laboratorium.......................... 242.1.10.4 Pemeriksaan Radiologi................................ 242.1.11Diagnosis Banding.................................................... 242.1.12 Penatalaksanaan......................................................... 252.1.12.1 Terapi Pembedahan.................................... 262.1.12.2 Terapi Adjuvan........................................... 28 2.1.12.2.1 Radioterapi................................ 28 2.1.12.2.2 Kemoterapi................................ 282.1.13Komplikasi................................................................ 302.1.14Prognosis................................................................... 31BAB III.METODE PENELITIAN.................................................... 323.1 Jenis Penelitian..................................................................... 323.2 Waktu dan Tempat Penlitian............................................... 323.2.1Waktu Penelitian....................................................... 323.2.2Tempat Penelitian...................................................... 323.3 Populasi dan Sampel penelitian............................................. 323.3.1Populasi Target........................................................... 323.3.2Populasi Terjangkau................................................... 323.3.3Sample....................................................................... 333.4Kriteria Inklusi dan Eksklusi................................................. 333.5Variabel Penderita................................................................. 333.6Definisi Operasional.............................................................. 331.Keluhan Utama........................................................... 332.Usia............................................................................. 343.Jenis Kelamin.............................................................. 344.Stadium Kanker Kolorektal........................................ 355.Derajat Histopatologi.................................................. 356.Kadar CEA (Carsinoma Embrionic Antigen)............ 367.Jenis Tatalaksana........................................................ 363.7Cara Pengumpulan Data........................................................ 373.8Cara Pengolahan dan Analisis Data...................................... 373.9Penyajian Data..................................................................... 373.10Rencana Kegiatan................................................................ 383.11Rencana Anggaran Penelitian.............................................. 393.12Kerangka Oprasional........................................................... 40BAB IV.HASIL DAN PEMBAHASAN........................................... 41 4.1.1Distribusi Berdasarkan Gejala Klinis..................................434.1.2Distribusi Berdasarkan Usia...............................................444.1.3Distribusi Berdasarkan Jenis Kelamin...............................464.1.4Distribusi Berdasarkan Stadium.......................................474.1.5Distribusi Berdasarkan Kadar CEA.................................494.1.6Distribusi Berdasarkan Histopatologi...................................504.1.7Distribusi Berdasarkan Penatalaksanaan..............................514.1.8Hubungan antara Kadar CEA dengan Stadium..................53

BAB VSIMPULAN DAN SARAN........................................555.1Simpulan.........................................................................555.2Saran..................................................................................56DAFTAR PUSTAKA................................................................................ 57

BIODATA................................................................................................... 61

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