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Chloride: The Forgotten EssentialMineral

By Dr. Chris Meletis N. D.

Chloride is an essential mineral for humans. It is abundant in ionic trace

mineral preparations. It is a major mineral nutrient that occurs primarily in body

fluids. Chloride is a prominent negatively charged ion of the blood, where it

represents 70% of the bodys total negative ion content. On average, an adult

human body contains approximately ! grams of chloride, ma"ing up about

#.!$ of total body weight.%he suggested amount of chloride inta"e ranges

from &!# to '## milligrams per day, based on the fact that total obligatory loss of

chloride in the average person is close to !(# milligrams per day. )s the principle

negatively charged ion in the body, chloride serves as one of the main electrolytes

of the body. Chloride, in addition to potassium and sodium, assist in the

conduction of electrical impulses when dissolved in bodily water. *otassium and

sodium become positive ions as they lose an electron when dissolved and chloride

becomes a negative ion as it gains an electron when dissolved. ) positive ion is

always accompanied by a negative ion, hence the close relationship between

sodium, potassium and chloride. %he electrolytes are distributed throughout all

body fluids including the blood, lymph, and the fluid inside and outside cells.+%he negative charge of chloride balances against the positive charges of sodium

and potassium ions in order to maintain serum osmolarity.

Pivotal Roles of Chloride in the Body

In addition to its functions as an electrolyte, chloride combines with hydrogen in

the stomach to ma"e hydrochloric acid, a powerful digestive enyme that is

responsible for the brea" down of proteins, absorption of other metallic minerals,

and activation of intrinsic factor, which in turn absorbs vitamin -+. Chloride is

specially transported into the gastric lumen, in exchange for another negatively

charged electrolyte bicarbonate/, in order to maintain electrical neutrality acrossthe stomach membrane. )fter utiliation in hydrochloric acid, some chloride is

reabsorbed by the intestine, bac" into the blood stream where it is re0uired for

maintenance of extracellular fluid volume. Chloride is both actively and passively

absorbed by the body, depending on the current metabolic demands. ) constant

exchange of chloride and bicarbonate, between red blood cells and the plasma

helps to govern the p1 balance and transport of carbon dioxide, a waste product

of respiration, from the body. 2ith sodium and potassium, chloride wor"s in the

nervous system to aid in the transport of electrical impulses throughout the body,

as movement of negatively charged chloride into the cell propagates the nervous

electrical potential.

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Deficiency of Chloride

3eficiency of chloride is rare. 1owever, when it does occur, it results in a life

threatening condition "nown as al"alosis, in which the blood becomes overly

al"aline. ) tedious balance between al"alinity and acidity is in constant flux, and

must be vigilantly maintained throughout the entire body. )l"alosis may occur as

a result of excessive loss of sodium, such as heavy sweating during endurance

exercise, and in cases of prolonged vomiting and diarrhea. 4ymptoms include

muscle wea"ness, loss of appetite, irritability, dehydration, and profound lethargy.

1ypochloremia may result from water overload, wasting conditions, and

extensive bodily burns with se0uestration of extracellular fluids. In a situation in

which infants were inadvertently fed chloride5deficient formula, many

experienced failure to thrive, anorexia, and wea"ness in their first year of life.(

Ecess Inta!e"

6xcessive inta"es of dietary chloride only occur with the ingestion of large

amounts of salt and potassium chloride. %he toxic effects of such diets, such as

fluid retention and high blood pressure, are attributed to the high sodium and

potassium levels.7Chloride toxicity has not been observed in humans except in

the special case of impaired sodium chloride metabolism, e.g. in congestive heart

failure.!1ealthy individuals can tolerate the inta"e of large 0uantities of chloride

provided that there is a concomitant inta"e of fresh water. Other situations in

which increased blood levels of chloride are seen include diseases of improper

waste elimination that occur in "idney diseases. 6xcess chloride is normally

excreted in the urine, sweat, and bowels. In fact, excess urinary excretion of

chloride occurs in high salt diets. 6xcessive inta"es of chloride can occur in a

person with compromised health in addition to an unhealthy diet. 1owever, those

that follow a healthy diet and lead an active lifestyle may need to consider

supplementing their diet with this important mineral.

Chloride vs. Chlorine

%he mineral supplement chloride is very different from the gas chlorine. 2hileelemental chlorine is a dangerous gas that does not exist in the free elemental state

in nature because of its reactivity, although it is widely distributed in combination

with other elements. Chloride is related to chlorine however, as one of the most

common chlorine compounds is common salt, 8aCl. Chloride is a by5product of

the reaction between chlorine and an electrolyte, such as potassium, magnesium,

or sodium, which are essential for human metabolism. Chloride salts are essential

for sustaining human metabolism and have none of the effects of isolated chlorine

gas.

#ources of Chloride

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Chloride occurs naturally in foods at levels normally less than #.(9 milligrams per

gram of food. %he average inta"e of chloride during a salt5free diet is

approximately ## milligrams per day. :nfortunately, chloride is foundcommonly combined with undesirable dietary sources. %he most common of

these negative sources is table salt. %able salt is made from a combination of

sodium and chloride ions. Other unhealthful sources include yeast extracts,

processed lunchmeats, and cheeses. 1ealthier sources of chloride include "elp

seaweed/, ionic trace minerals, olives, rye, tomatoes, lettuce, and celery, although

not in large enough amounts to supply the needs of an active adult.9In its original

form, however, chloride is leached from various roc"s into soil and water by years

of weathering processes. %he chloride ion is highly mobile and is transported to

closed basins, such as the $reat #alt a!e, or oceans.&

#ummary

Chloride is a highly important, vital mineral re0uired for both human and animal

life. 2ithout chloride, the human body would be unable to maintain fluids in

blood vessels, conduct nerve transmissions, move muscles, or maintain proper

"idney function. )s a major electrolyte mineral of the body, chloride performs

many roles, and is rapidly excreted from the body. )ctive adults that eat a healthy

diet devoid of salt and illnesses in which vomiting and;or diarrhea are profuse

warrant the supplementation of additional chloride. . *hysiology of the human "idney. 8ew ?or", 8?, >rune and

4tratton, '9'@ !'

+2east

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9 )ltschul )F, >rommet E. Aood choices for lowering sodium inta"e.

1ypertension 'B+ 4ep5OctD7! *t +/@III95+#

& >elb 4-, )nderson F*. 4ources of chloride and sulfate in ground water beneath

an urbanied area in 4outheastern 2isconsin