Post on 01-Feb-2023
Running head: CASE STUDY NEONATAL HEAD COOLING 1
Case Study 1: Head Cooling as Treatment for Neonatal Encephalopathy
NURS 6035 Practicum I
Teresa Z. Baker
Texas Woman’s University
CASE STUDY NEONATAL HEAD COOLING 2
Case Study 1: Head Cooling as Treatment for Neonatal Encephalopathy
Preliminary Information
Selection of Case
Previously, I worked in a Level IV Neonatal Intensive Care Unit (NICU) which provided
head cooling therapy for the treatment of neonatal encephalopathy. Currently I am working in a
smaller NICU which is not equipped nor trained to provide this therapy. The smaller NICU,
however, transports neonates with hypoxic ischemic encephalopathy to the Level IV NICU that
does provide head cooling therapy. I selected this case because it presented the opportunity to
not only learn about head cooling therapy, but how to prepare and transport an infant who is
being transferred for head cooling therapy. There is little literature available regarding preparing
an infant for transport to a cooling center. As studies have demonstrated positive results with
cooling therapy, the treatment has become more popular. Due to the small number of cooling
centers available in Texas, there have been an increased number of infants being transported for
cooling therapy as treatment of neonatal encephalopathy. I wanted to share this information with
my peers for whom transporting an infant for cooling therapy may become necessary.
Type and Number of Encounters
M.P. was delivered in an outlying hospital and was admitted to the NICU for respiratory
distress and perinatal asphyxia. Shortly after birth, infant was transported to a larger NICU which
provided adequate testing and cooling therapy for asphyxiated infants.
Insurance
This patient is on the state-funded Medicaid plan.
CASE STUDY NEONATAL HEAD COOLING 3
Subjective
Patient Profile
M.P. is a newborn Hispanic female, who delivered at 38 3/7 weeks gestation. She was
admitted to the Neonatal Intensive Care Unit (NICU) from the delivery suite.
Background Information
CC. Patient was born with perinatal asphyxia. M.P. was admitted to the NICU for
Hypoxic-Ischemic Encephalopathy.
HPI. Infant was delivered emergently in the operating room for fetal bradycardia.
PMH.
Birth. M.P. was 38 3/7 weeks gestation, delivered by emergent caesarean section to a
gravida 1, Para 1, 20-year old Hispanic female, who received prenatal care at the Prenatal
Clinic. The pregnancy was complicated by increased glucose and was diet-controlled.
There was no exposure to medications, alcohol, recreational drugs, or tobacco. Her
prenatal screening labs were negative. Labor was complicated by meconium stained
amniotic fluid and maternal transient hypotension after an epidural was administered.
The hypotension improved with positioning and a dose of Ephedrine. Following the dose
of Ephedrine, severe fetal bradycardia was noted via scalp electrode monitoring. Mother
was transferred to the operating room and an urgent caesarean section was performed.
By the time of delivery the infant had been without a detectable heart rate for at least five
minutes.
Birth time: 2323 on 8/19.
Birth weight: 2675 grams.
Length: 49.5 centimeters.
CASE STUDY NEONATAL HEAD COOLING 4
Head circumference: 32 centimeters.
Apgars: 0 at one minute; 2 at five minutes; 3 at ten minutes.
M.P. delivered with meconium stained amniotic fluid. Tone was floppy, color was pale,
no respiratory effort or heart rate was noted at the time of birth. She was intubated with a
3.5 endotracheal tube (ETT) and meconium was suctioned from below the vocal cords.
Bulb suctioning was performed and face mask ventilation was initiated. Despite
ventilation, no heart rate was noted at one minute of age. Chest compressions were
started and the infant was reintubated with a 3.5 ETT. Bag ventilation was initiated.
No heart rate was detected for 3 minutes of chest compressions and ventilation.
Epinephrine was given through the ETT. After approximately 30 seconds, a heart rate
was detected, which gradually increased to a rate of 150 beats per minute. M.P. was pink
with improved perfusion but continued to have floppy tone, was unresponsive, and had
occasional agonal breaths. She was transferred to the NICU for further management.
M.P. was placed on the conventional ventilator. A peripheral intravenous catheter was
placed. An umbilical venous catheter was placed and an umbilical arterial catheter was
attempted without success. Blood was drawn for a complete blood count (CBC), blood
cultures, and a blood gas. The CBC showed a left shift, with 34 neutrophils and 18
bands. Ampicillin and Cefotaxime were started until sepsis could be ruled out.
Ventilator settings were adjusted based on the blood gas. Since perinatal asphyxia was
suspected from the history of events, M.P. was placed in a radiant warmer with all heat
turned off and a temperature probe in place. The temperature was targeted at 33 degrees
Celsius. D10W intravenous fluid was initiated, but restricted to 60 milliliters per
kilogram (mg/kg) per day. The initial blood glucose was 110 milligrams per deciliter.
CASE STUDY NEONATAL HEAD COOLING 5
One hour. At approximately one hour of age, M.P. was noted to have seizure activity
with eye blinking, posturing and tremulous movement of the upper and lower extremities.
The initial pH on the arterial blood gas was 6.87, paCO2 was 95 and the base excess was
-19.0, showing metabolic acidosis. A 10 milliliter bolus of Sodium Bicarbonate was
given. A repeat blood gas drawn, following the bolus and ventilator changes, showed
marked improvement. The pH increased to 7.22, the paCO2 decreased to 27 and the base
excess improved to -15. Her blood pressure was 40/26 (33) and a 10 ml/kg normal saline
bolus was given intravenously. Dopamine and Dobutamine were initiated intravenously
for hypotension and hypoperfusion. Phenobarbital was given for seizure activity. The
cooling center was contacted and the transport team was dispatched to the outlying
hospital to transport the baby.
Two hours. M.P. continued to have seizure activity and a dose of Keppra was given
intravenously. The temperature was maintained between 32 and 34 degrees Celsius.
The transport team arrived and obtained an arterial blood gas. The pH was 7.34,
paCO2 was 29, and base excess had improved to -10 from the previous blood gas. The
infant was transferred to the transport incubator, with no heat applied. Skin temperature
probe was applied.
Parents and grandparents were allowed to visit with M.P. while the transport team
were readying for departure. Their questions were answered and directions to the
destination cooling center were given. The transport team departed with the infant via
helicopter at approximately two and one half hours of age. At this time, care was
assumed by the staff of the cooling center.
CASE STUDY NEONATAL HEAD COOLING 6
Four hours. Word was received that M.P. had arrived at the cooling center. According
to report, a 20 minute amplitude-integrated electroencephalogram (aEEG) was done to
assess for seizures and neurological status. M.P. continued to have seizure activity after
arrival at the cooling center.
Five hours. M.P. was placed on the head cooling apparatus at approximately five hours
and 20 minutes of age. She remained on the head cooling therapy for 72 hours and
gradually rewarmed.
Two to twenty days. The cooling center reported that M.P. had weaned off the ventilator
to nasal cannula and off pressors on the fourth day of life (DOL). She weaned off nasal
cannula to room air on the ninth day of life. M.P. had been on hyperalimentation fluids
(HAF) that were adjusted daily to maintain laboratory results in normal range. HAF was
tapered off as nipple feeding with 22 calorie formula improved. M.P. was on a
maintenance dose of Keppra with no further evidence of seizures. A magnetic resonance
imaging (MRI) study conducted on the fifth day of life was unremarkable. The aEEG
showed diffuse slowing with no seizure activity. A 24-hour video EEG did not show
seizures.
M.P. gradually increased feeding to ad lib by nipple with 22 calorie formula,
voiding and stooling normally, and having no further seizure activity on Keppra.
M.P. roomed in with her parents and was discharged on DOL 20.
Medications. Keppra 66.9 mg, by mouth, every 12 hours.
Family History.
Mother. Hispanic female who speaks English. She does not work outside the home.
CASE STUDY NEONATAL HEAD COOLING 7
Father. Hispanic male who speaks Spanish. He is employed full time as a construction
worker. Mother reports that he is in “good health”.
Additional family information. There are no other children in the family. M.P. will be
living with her biologic mother and father. The family resides in a private home in Bryan.
They are currently receiving state funded insurance. There are no reported genetic
disorders on either side of the family.
Social History. M.P. has extended family that lives nearby. The maternal grandparents
were present at the delivery and are very supportive. The family religion is Catholic and
the family attends church regularly.
Review of Systems on Admission.
Head/Neck. Appears normocephalic. No dysmorphic features.
Skin. Warm and dry to touch. No rashes or birthmarks noted.
Eyes. Normal placement. Red reflex present bilaterally. Sluggish pupillary response.
Ears. Normal placement.
Nose. Normal placement.
Oropharynx. Infant is intubated. Feeding tube to gravity.
Cardiac. Normal sinus rhythm. Decreased perfusion. No murmur noted.
Respiratory. Breath sounds equal and clear, on conventional ventilator. Occasional
spontaneous respirations noted. Good air movement.
Abdomen. Soft, non-distended, no masses or organomegaly. Faint bowel sounds heard.
Three vessel cord, stained with meconium. Umbilical venous catheter in place.
GU. Normal term female genetalia. No stool or urine output since birth.
Neuro. Depressed since birth.
CASE STUDY NEONATAL HEAD COOLING 8
Extremities. Occasional tremulous movements noted. Seizure activity noted.
Growth/Development. Infant is appropriate for gestational age. Unable to assess
development at this time.
Objective
Physical Examination
General. M.P. is a term, female newborn, on conventional ventilator, lying quietly in
radiant warmer with the heat turned off.
Vital Signs. T: 95 Rectally. HR: 130. RR: 40 (SIMV). BP: 40/26(33)
Weight. 2.675 kg.
Length. 49.5 cm.
Head Circumference. 32 cm.
Head/Neck. Head appears normocephalic. Anterior fontanel soft, flat. No scalp edema
noted. Neck supple.
Skin. No abnormalities noted.
Eyes. Red reflex bilaterally. Sluggish pupillary reaction.
Ears. Normal placement. No discharge or tags noted.
Nose. Nares patent. Good air movement.
Orophyarynx. ETT in place. Orogastric tube in place to gravity. Palate intact. No
abnormalities noted.
Cardiac. Heart sounds normal with no murmur noted. Decreased perfusion, but
improving. Femoral pulses strong.
CASE STUDY NEONATAL HEAD COOLING 9
Respiratory. Chest is symmetric. Nipples are normally placed. Breath sounds equal,
clear, good air movement, on conventional ventilator. Vent settings: Rate 40, Peak 22,
Peep 5, Itime: 0.40. FiO2 .45.
GI. Abdomen soft, flat, no masses or organomegaly. Umbilical venous catheter in place.
Three vessel cord with meconium staining.
GU. Normal term female genetalia. Anus patent with normal wink.
Extremities. Normal appearance of upper and lower extremities. Normal creases.
Peripheral catheter in place in left foot.
Back. Spine appears straight. No sacral dimple noted.
Neuro. Hypotonia of trunk. Hypertonia of extremities. Occasional tremulous
movements of the upper and lower extremities. Brief opisthotic posturing. No suck or gag
reflex elicited. No response to painful stimuli.
Musculoskeletal. Decreased tone in trunk. Increased tone in extremities.
Growth/Development. Infant appears appropriate size for gestational age. Unable to
assess development at this time.
Diagnostic Tests.
The following test results were obtained and discussed with parents.
Complete blood count. Values normal except for left shift on the differential.
Blood cultures. Blood cultures were negative for sepsis.
Blood gases. Blood gases were initially abnormal, but were corrected with conventional
ventilation and sodium bicarbonate and normal saline boluses.
Infant was referred to a cooling center for assessment of hypoxic-ischemic
encephalopathy to include head cooling selection criteria, aEEG, video EEG, Sarnat
CASE STUDY NEONATAL HEAD COOLING 10
Score, and MRI.
Head cooling criteria: M.P. met Criteria A, B, and C for head cooling therapy.
Discussion of Findings
Hypoxic-ischemic encephalopathy (HIE) is a term used to describe the condition
resulting from reduced oxygen to the brain, before and/or during the delivery of an infant. HIE
is a serious condition that causes significant mortality and morbidity in the neonatal population.
This condition affects 1-8 neonates per 1000 births and can result in major brain injury (Zanelli,
Stanley, & Kaufman, 2009). “Preventing the secondary reperfusion injury that occurs following
a hypoxic-ischemic event is paramount to ensuring the best possible neurologic outcome for the
neonate” (Long & Brandon, 2007).
“Seizures increase the risk of neurological sequelae by as much as forty fold. Early
onset of seizures increases the risk of adverse outcome and the risk is approximately 75 percent
with onset in the first four hours” (Volpe, 2008, p 441). Seizures may cause further injury to the
brain. The long-term sequelae may include mental retardation, seizures, cerebral palsy, epilepsy,
blindness, hearing impairment, learning disability, and other mental and psychomotor deficits.
Magnetic resonance imaging (MRI) study is the most accurate diagnostic test for hypoxic
ischemic injury in the newborn (Volpe, 2008, p.414).
Recent studies have suggested that cooling therapy is of benefit for the outcome of
infants with HIE (Zanelli, Stanley, & Kaufman, 2009). The National Institute of Child Health
and Human Development Neonatal Research Network conducted a large, multicenter,
randomized trial from 2000 to 2003 and found that whole body cooling significantly reduced the
risk of death or disability for neonates diagnosed with moderate or severe HIE ( Shankaran et al.,
2005). The beneficial mechanism for hypothermia appears to be partially in relation to reduction
CASE STUDY NEONATAL HEAD COOLING 11
of energy consumption and decrease in the accumulation of extracellular glutamate (Volpe,
2008, p. 460).
There is a therapeutic window of opportunity during which hypothermic intervention can
decrease the amount of cell death resulting from secondary energy failure. If selective
brain cooling can be initiated during the first 6 hours after the injury and the baby’s brain
is kept cool for the duration of the secondary energy failure state, science has
demonstrated selective head cooling can interrupt the second phase of the injury and have
a significant effect on the severity of the secondary cell death (www.natus.com).
Asphyxiated neonates have complex medical needs and should be cared for in intensive
care units that can provide multidisciplinary subspecialty evaluation and treatment. Most
neonates who meet the criteria for hypothermia therapy will be born in hospitals that do
not provide this high level of care (Fairchild, Sokora, Scott, & Zanelli, 2010).
Since many of the neonates who deliver with perinatal asphyxia are born in remote
hospital settings, investigation into how best to manage these patients in a safe and timely
manner is warranted, to avoid long-term sequelae (Zanelli, Stanley, & Kaufman, 2009).
Neither the NICHD nor the CoolCap trial recommended cooling before arrival
at the study center (Anderson, Longhofer, Phillips, & McRay, 2007).
Clinical evidence of moderate to severe HIE is defined by criteria A, B, and C below.
The infant should meet these three criteria to be considered a candidate for head cooling therapy.
Criteria A. Infant at > 36 weeks gestational age and at least one of the following:
Apgar score <5 at 10 minutes
Continued need for resuscitation, including ventilation at 10 minutes after
birth.
CASE STUDY NEONATAL HEAD COOLING 12
Acidosis defined as arterial pH < 7.00 within 60 minutes of birth.
Base excess < -16 mmol/L within 60 minutes of birth.
Criteria B. Infant with moderate to severe encephalopathy consisting of altered state of
consciousness (as shown by lethargy, stupor, or coma) and at least one of the following:
Hypotonia
Abnormal reflexes, including oculomotor or papillary abnormalities
Absent or weak suck
Clinical seizures
Criteria C. Infant has an aEEG recording of at least 20 minutes duration that shows
either moderately severe abnormal aEEG background activity OR seizures
(www.natus.com).
Assessment
Diagnoses
Acute Diagnoses
Hypoxic-Ischemic Encephalopathy (768.5). M.P was born with perinatal asphyxia.
Asphyxia is defined by: pH on blood gas < 7.00, Apgar score of 0-3 for more than five
minutes after birth, neurologic manifestation in the immediate neonatal period (seizures,
hypotonia, coma), and evidence of multi-organ system dysfunction in the immediate
neonatal period (Zanelli, Stanley, & Kaufman, 2009).
Chronic Diagnoses
1. Seizures (779.0). HIE is often the most frequent cause of neonatal seizures. Infarcts
occur with neonatal seizures in 80% of patients. Subtle seizures may occur with HIE
(Zanelli, Stanley, & Kaufman, 2009). M.P. began having seizures within an hour
CASE STUDY NEONATAL HEAD COOLING 13
after birth which were controlled with medication. She was discharged on Keppra
for the prevention of seizures.
2. Developmental Delay (783.40). Monitoring specific developmental milestones are
essential for determining the presence of delay. These milestones include cognitive, fine
and gross motor skills (Feigelman, 2007).
Differential Diagnosis
Posterior Cerebral Fossa Hemorrhage (767.0). On occasion, difficulties with delivery,
particularly with breech presentation, hemorrhage in the posterior cerebral fossa should be
considered as an alternate diagnosis. However, this is a rare condition (Zanelli, Stanley, &
Kaufman, 2009). Posterior cerebral fossa hemorrhage usually occurs in full term infants with a
traumatic breech or forceps delivery.
Typical signs include: apathy, irritability, vomiting, high-pitched crying, respiratory
insufficiency, bradycardia, tense anterior fontanelle, increased circumference of the
head, hypotonia, nystagmus, palsies of diverse cranial nerves, depression of primitive
reflexes, coma and seizures. Diagnosis is verified by computerized topography (CT) scan
or sonography. Other important data include blood-tinged cerebral spinal fluid, a fall of
hemoglobin concentration and intraretinal hemorrhage. Electroencephalogram (EEG)
are often normal (von Gortand, Arnold, & Adis, 1988).
M.B. had no evidence of hemorrhage on MRI.
Impressions
Infants who survive severe HIE, may have persistent feeding difficulties requiring tube
feeding for weeks to months. (Zanelli, Stanley, & Kaufman, 2009). When M.P. was discharged
CASE STUDY NEONATAL HEAD COOLING 14
from the hospital at 20 days of age, she was nipple feeding well. She was gaining weight on 22-
calorie formula. It will be important to track her feedings and weight trends.
M.P. should be monitored for seizures. The MRI performed at five days of age was
unremarkable. A 24-hour video EEG did not show seizures, on a maintenance dose of Keppra.
She was discharged on Keppra at 66.9 mg, by mouth, every 12 hours. She has had no recurrence
of seizures. She should be followed by a pediatric neurologist.
It is essential that M.P. be monitored for cognitive, fine, and motor skills to determine
potential presence of developmental delay (Feigelman, 2007). Among infants who survive
moderately severe HIE, 10-20% have minor neurological morbidities. In the absence of obvious
neurological deficits in the neonatal period, there may be long-term functional impairments.
Children with a history of moderate to severe HIE should be monitored into school age (Zanelli,
Stanley, & Kaufman, 2010).
The patient has a very supportive family who is attentive to her needs. Both parents and
grandmother are very proficient at feeding M.P.
M.P. should be assessed in the future for the need for the Early Childhood Intervention
program. In the event that developmental delays or learning disabilities are assessed, this
program would benefit M.P. by providing occupational therapy, physical therapy, and a number
of other different services, at no cost.
Immediate Plan
Neurological Assessment
1. Evaluate neurological status
2. Establish need for hypothermia treatment according to criteria for hypoxia.
Transport
CASE STUDY NEONATAL HEAD COOLING 15
1. Initiate contact with cooling therapy center regarding potential preparation and
expedient transport of infant hypothermia.
Passive Cooling
1. Upon approval by accepting center, begin passive cooling until arrival of transport
team.
2. Maintain rectal temperature at 33oC to 35
oC as directed by cooling center.
Blood Pressure Management
Maintain blood pressure within normal limits with Dopamine, Dobutamine
Fluid Management
Assure fluid restriction at 60-80 ml/k/d.
Seizure Management
1. Administer medications to control seizures.
Rationale: Educating referring clinicians about when and how to initiate therapeutic
hypothermia is a cornerstone to a successful program. It is recommended that in cases of acute
perinatal distress with suspected HIE, the radiant warmer should be turned off and the baby’s
temperature closely monitored during initial stabilization and neurological assessment. If the
neurological examination is not consistent with moderate to severe encephalopathy, the baby
can then be transitioned to routine thermal care. If the baby meets criteria for therapeutic
hypothermia, passive cooling is continued until the arrival of the transport team (Fairchild,
Sokora, Scott, & Zanelli, 2010).
Plan Following Discharge
Feeding Management
1. Continue to monitor M.P.’s intake.
CASE STUDY NEONATAL HEAD COOLING 16
2. Continue to monitor weight gain.
3. Follow with occupational therapy should feeding problems develop.
Development
1. Monitor developmental milestones
2. Monitor for functional difficulties well into school age.
2. Referral to Early Childhood Intervention, should deficits be noted.
3. Refer to occupational or physical therapy if problems are noted.
Seizure Management
1. Continue maintenance dose of Keppra for prevention of seizures.
2. Follow-up with pediatric neurologist.
Referrals
1. Pediatrician in M.P.’s home town.
2. Pediatric neurologist for seizure medication management.
3. Early Childhood Intervention for family assistance in long-term management.
Rationale: When functioning in the role of care provider, the DNP must assist in coordinating
multidisciplinary care for the complex pediatric patient.
Anticipatory Guidance
1. Follow with general pediatric healthcare provider for routine wellness examinations.
2. Recommended 2 month immunizations.
3. Seasonal vaccines for patient and family.
4. Parent teaching regarding basic growth and development. Establish understanding of
normal physical, cognitive and emotional expectations of M.P.
CASE STUDY NEONATAL HEAD COOLING 17
Rationale: The DNP must treat the whole patient, to include basic treatments and
teaching, assuring optimal growth and development. As M.P. ages, she will be expected
to reach specific developmental, functional, and social milestones. Teaching the parents
about these expectations allows them to recognize irregularities, should they appear
(Feigelman, 2007).
Family Support
Patient Handouts:
1. Hypoxic-Ischemic Encephalopathy (HIE) and Selective Head Cooling with the
Olympic Cool-CapR System Parent Frequently Asked Questions (see Appendix).
Rationale: The Doctor of Nursing Practice (DNP) must provide high quality, reliable
information for patients and families. The DNP must take into consideration the reading
literacy and health literacy levels in order to offer understandable information to
patients. The DNP should provide hard copies of documents, if the family does not have
access to the internet (United States Department of Health and Human Services, 2008).
Referral to Early Childhood Intervention
Rationale: ECI is a service provided through the Texas Department of Assistive and
Rehabilitation Services (2007). ECI provides no-cost services for those patients enrolled
in Medicaid. Programs are available for patients with cognitive, motor, communicative,
and social-emotional difficulties. M.P. is at risk for developmental, motor, functional,
and learning disabilities.
CASE STUDY NEONATAL HEAD COOLING 18
References
Anderson, M.E., Longhofer, T.A., Phillips, W., McRay, D.E. (2007). Passive cooling to initiate
hypothermia for transported encephalopathic newborns. Journal of Perinatology, 27:
592-593.
Fairchild, K., Sokora, D., Scott, J., & Zanelli, S. (2010). Therapeutic hypothermia on neonatal
transport: 4 year experience in a single NICU. Journal of Perinatology, 30:324-329.
Feigelman, S. (2007). The first year. In R. Kleigman, R. Behrman, H. Jensen & B. Stanton
(Eds.), Nelson textbook of pediatrics, (18th
ed., pp. 43-48). Philadelphia: Saunders
Elsevier.
Gluckman, P. D., Wyatt, J. S., Azzopardi, D., Ballard, R., Edwards, A.D., Ferriero, D.M., Polin,
R.A., Robertson, C.M., Thoresen, M., Whitelaw, A., & Gunn, A.J. (2005). Selective head
cooling with mild systemic hypothermia after neonatal encephalopathy: Multicentre
randomized trial. The Lancet, 365: 663-670.
Long, M., & Brandon, D., (2007). Induced hypothermia for neonates with hypoxic-ischemic
encephalopathy. Journal of Obstetric, Gynecologic, and Neonatal Nursing, 36 (3): 293-
298.
Olympic Cool-Cap System: Selective head cooling. (2009). Natus Medical Incorporated.
Retrieved from http://www.natus.com
Shankaran , S. , Laptook , A. , Ehrenkranz , R. , Tyson , J. , McDonald , S. , Donovan , E ., et al .
( 2005 ). Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy .
NewEngland Journal of Medicine , 353 , 1574 - 1584.
Texas Department of Assistive and Rehabilitation Services (2007). What is ECI? Retrieved from
http://www.dars.state.tx.us/ecis/index.shtml
CASE STUDY NEONATAL HEAD COOLING 19
United States Department of Health and Human Services. (2008). Health literacy improvement.
Office of Disease :Prevention and Health Promotion: Health Communication Activities.
Retrieved November 12, 2009, from http://www.health.gov/communication/literacy/
Volpe, J. J. (2008). Hypoxic-ischemic encephalopathy: Clinical aspects. Neurology of the
newborn (5th
ed., pp. 414-460). Philadelphia: Saunders Elsevier.
Von Gortand, A., Arnold, D., Adis, B. (1988). Posterior fossa hemorrhage in the newborn
period-diagnosis and management. Pediatric Radiology, 18: 347-348.
Zanelli, S., Stanley, D., & Kaufman, D., (2009). Hypoxic-Ischemic Encephalopathy. Retrieved
from http://emedicine.medscape.com/article/973501
CASE STUDY NEONATAL HEAD COOLING 20
Appendix
Hypoxic-Ischemic Encephalopathy (HIE) and Selective Head Cooling with the
Olympic Cool-CapR System
Parent Frequently Asked Questions
Your baby has a condition called hypoxic-ischemic encephalopathy (also abbreviated as HIE).
HIE is the term used to describe the condition whereby your baby’s brain has been deprived of
oxygen, before and/or during delivery. The seriousness of this condition is based on how long
his/her brain was without oxygen, the affected region of your baby’s brain, and the maturational
state of his/her brain cells.
HIE is a progressive injury that can develop over the next few hours to days. There are three
categories of HIE; mild, moderate, and severe. Most babies with mild HIE will recover with no
disability. Approximately 40-70% of babies with moderate HIE have some form of lifelong
disability such as cerebral palsy, cognitive deficits, and/or seizures. The most severe cases
almost always result in severe disabilities or death. Severe disabilities may include mental
retardation, severe motor dysfunction, and/or seizures.
What can be done to treat HIE?
Traditionally, babies with HIE were treated with supportive care: help breathing with a
ventilator, management of blood pressure, and/or management of seizures. There was no other
approved treatment for HIE. The Food and Drug Administrations (FDA) has now approved the
Olympic Cool-Cap System for the selective head cooling treatment of neonatal HIE.
What is selective head cooling and the Olympic Cool Cap System?
Science has shown that if your baby’s brain can be cooled down below normal body (normal
body temperature = 37o C) temperature (hypothermia) within 6 hours of birth, and their body
temperature kept in a consistent hypothermic range of 34oC to 35
oC for 72 hours, the Cool-Cap
system may interrupt the evolution of progressive damage to your baby’s brain, and may reduce
or prevent significant disability or death. While your baby’s head is kept cool, the rest of his/her
body will only experience mild hypothermia and will actually receive some warmth through the
radiant warmer. Because your baby’s head is kept cooler than the rest of his/her body, the
technique is called selective head cooling.
The Cool-Cap system uses a sealed water cap and two insulating caps placed over your baby’s
head. The temperature of the water cap is adjusted up or down to maintain the core body
temperature in the hypothermic range of 34oC
to 35
oC for the treatment duration. Once the
cooling treatment is complete, there is a 4-hour rewarming period. The water cap is removed
and the baby is allowed to slowly warm back up to a normal temperature. Your baby’s nurse
will carefully monitor your baby during the entire treatment to ensure his/her core temperature
remains in the target temperature range during the cooling treatment.
Olympic Medical, a Natus company 1 of 2 60099-FLF-EN0405R
CASE STUDY NEONATAL HEAD COOLING 21
What are the side effects of selective head cooling with the Olympic Cool-Cap System?
There are two expected, benign side effects associated with selective head cooling with the Cool-
Cap system, although not all babies will experience these side effects. The first is called minor
cardiac arrhythmia. A cardiac arrhythmia refers to an abnormality in the rhythm of your baby’s
heartbeat. The specific minor cardiac arrhythmia is called sinus bradycardia (a slow heartbeat)
and it is known to be associated with hypothermia.
The second side effect is head or scalp edema. Edema means swelling. This condition generally
goes away y itself, or with scalp massage or re-positioning. During the 72-hour treatment with
the Cool-Cap system, your baby’s nurse will regularly check under the water cap and around the
chinstrap to make sure there is no skin breakdown.
Does the Olympic Cool-Cap System cause my baby pain?
No. The Cool-Cap system is completely non-invasive.
What can I do to help my baby during the treatment?
It is extremely important that your baby rests during the entire treatment. You may stay with
your baby (per NICU guidelines), but try to keep your stimulation and interruptions to a
minimum. You can coordinate your interaction with your baby’s nurse to maintain the best
environment for your baby.
Your baby will not be fed via a bottle during the treatment. He/she will receive nutrition via an
intravenous (IV) line. Please continue to pump and store your breast milk.
Where can I find more information regarding HIE?
http://www.natus.com/
Olympic Medical, a Natus company 2 of 2 60099-FLF-EN0405R