Post on 03-Jun-2018
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STRUCTURE
ENDOCRINE GLAND
WIDA PURBANINGSIH, dr.
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Kelenjar Endokrin
Berasal dari sel epitel.
Biasanya berkelompok, kecuali kelenjar tiroid.
Selalu dekat dengan kapiler, dan mempunyaihubungan fenestrated.
Sekeresinya bekerja ditempat yg jauh, kecuali :
Parakrin (gastrin dari sel G),
Juxtakrin(somatostatin pankreas), Autokrin.
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ENDOCRINE GLAND
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HIPOFISIS (pituitari)
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- Berat : 0,5 g.
- 10x13x6 mm.
- Sela tursika.
Neurohipofisis Adenohipofisis
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Neurohipofiis (hipophysis posterior)
# Sekitar 100.000 axon takbermielin dari neuron
sekretorik :1. Nc. Paraventrikular--.>
oxitosin
2. Nc. Supra optikus - Vasopresin, ADH,arginine
# Badan Herring ; produkneurosekresi di axon.
# Neurophysisn : bindingprotein# Pituisit (25%) Sel glia
.
Posterior Pituitary
Pulasan trikom Mallory
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Adenoipofisis
A. Pars distalis : 75% hipofisis.Fibroblast sbg penyokong.
1. Kromofob : clearsel undifferentiated, sel follikular-penyokong)
2. Kromofil :Sel AsidofilikSomatotrofik (GH)mamotrofik (prolactin)Sel Basofilikgonodotropik (FSH, LH), tirotropik(TSH) kortiokotropik (ACTH)
B. Pars Tuberalis : Mengelilingiinfudibulum.FSH dan LH.
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Adenohipofisis
C. Pars Intermedia
Berkembang dari
Kantong Rathke. Pada manusia
rudimenter, tdd ; sel
basofilik lemah, granul
kecil. Menghasilkan ß MSH
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Gomori trichrome provides similar information. X400. Cords of acidophils and basophils vary in
distribution and number in different regions of the pars distalis, but are always closely
associated with capillaries and sinusoids (S) in the second capillary plexus of the portal
system. The vascular plexus carries off secreted hormones into the general circulation. Specific
acidophil or basophil cells can be identified immunohistologically with antibodies against their
hormone products. Chromophobes are less numerous and represent various undifferentiated
parenchymal cells. Their number and density also vary in different regions.
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Acidophil cells(A), Basophils (B)
Chromophobes (C) in which the cytoplasm is
poorly stained. X400. H&E.
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The micrograph shows somatotropic cells (S) stained
using an antibody against somatotropin. X400.
Hematoxylin counterstain.
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Kelenjar Tiroid
Lokasi : anterior laring.
Terdiri dari 2 lobus.
Tersusun : 20-30 juta folikel.
Kapsul : masuk ke dalammembentuk septamemisahkan masing –
masing folikel.
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Approximately 5 cm x 5 cm and weighing 20 –
30 gin adults.
surrounding the anterior surface of the trachea
just below the larynx.
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Follicular
Sel folikel :kuboid rendahsilindris
Sel parafolikular.
Koloid :Glycoprotein(thyroglobulin).
Irregular connect ive t issue : reticular fibers.
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PARATHYROID GLANDS
Ada 4 kelenjar, 3x6 mm Lokasi : belakang kel. tiroid.
Kapsul septa masuk ke dlmkelenjar, merge with the reticular
fibers. Chief cel ls : Sel poligonal kecil,
vesicullar nucleus, terpulas pucat,sitoplasma sedikit asidophilik.Menghasilkan :hormon paratiroid
Oxyphyl cells: sel poligonal besar,acidophylic mitochondria withabudant cristae. Fungsi : blm jls.
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P
A
R
AT
H
Y
R
OI
D
G
L A
N
D
S
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ISLETS OF LANGERHANS
Sbg kelompok sel-sel, berbentuk bulat.
Tdd sel-sel yg terbenam dalam kel. Eksokrin.
Mrp Multihormonal endocrine microorgans.
Diameter : 100-200µm.
> I juta islet of langenhans/ pankreas.
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Tdd : 4 jenis sel.1. Sel asidofil (alfa) .
Susunan granul teratur,
menghasilkan glukagon.
2. Sel Basofil (beta):
Granul tidak teratur, di pusatnya terdapat
kristal insulin tak beraturan tergabung denganseng. Menghasilkan insulin
3. Sel D: somatostatin, menghambatpelepasan hormon oleh sel kel. di sekitarnya.
4. Sel F : polipeptida pankreas, f/ ; blm jls.
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Glukagon terpulas coklat dengan pemeriksaan histokimia
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KELENJAR ADRENAL( SUPRARENAL)
Sepasang, di kutub atas
ginjal, terbenam dlm jar.
Lemak.
Pjg : 4-6 cm, lebar : 1-2 cm,
tebal 4-6 cm.
Berat + 8 gram.
Tdd : Korteks mesoderm
intermediet. Medulla krista neuralis.
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Korteks Adrenal
Berdasarkan disposisi dan gambaran selnya korteks
adrenal dibagi mjd 3 lapisan :1. Zona glomerulosa.
2. Zona fasikulata.
3. Zona retikularis.
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Zona Glomerulosa
15% volume adrenal
Sel-sel columnar/piramidal, tersusun rapat membentuk
deretan bundar atau melengkung, dikelilingi kapiler.
Produksi hormon mineralocorticoid (Aldosteron)
Keseimbangan elektrolit : Na, K
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Zona Fasiculata
65% volume adrenal
Sel polihedral, mengandung tetesan lipid banyak
vakuola Spongios i t .
Sel tersusun memanjang.
Produksi glukocorticoid (Cortison, cortisol) &
androgen (dehydroepiandrosterone)
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Zona Reticularis
7% volume adrenal
Sel kecil, tidak teratur, intik piknotik (cell death).
Sel tersusun tidak teratur dan membentuk anyaman.
Terdapat granula lipofushin (besar dan banyak)
Produksi glukocorticoid & androgen
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