Download - Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Transcript

Page 1: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 2: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 3: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 4: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 5: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 6: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 7: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 8: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 9: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 10: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 11: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 12: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 13: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 14: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 15: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 16: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 17: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 18: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 19: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 20: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Accepted Manuscr

ipt

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 21: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Accepted Manuscr

ipt

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 22: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 23: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 24: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 25: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Acce

pted M

anus

cript

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 26: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Accepted Manuscr

ipt

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Page 27: Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Biochemical Journal Immediate Publication. Published on 20 Aug 2013 as manuscript BJ20130123TH

IS IS

NO

T TH

E VE

RSI

ON

OF

REC

OR

D -

see

doi:1

0.10

42/B

J201

3012

3

Accepted Manuscr

ipt

Licenced copy. Copying is not permitted, except with prior permission and as allowed by law.© 2013 The Authors Journal compilation © 2013 Biochemical Society

Top Related

Tomato SP-Interacting Proteins Define a Conserved Signaling ...

Tomato SP-Interacting Proteins Define a Conserved Signaling ...

The C-terminus of the metabotropic glutamate receptor 1b regulates dimerization of the receptor

The C-terminus of the metabotropic glutamate receptor 1b regulates dimerization of the receptor

Math1 Target Genes Are Enriched With Evolutionarily Conserved Clustered E-box Binding Sites

Math1 Target Genes Are Enriched With Evolutionarily Conserved Clustered E-box Binding Sites

Thirring model with non-conserved chiral charge

Thirring model with non-conserved chiral charge

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis

Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved

Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved

GENETIC DIFFERENTIATION AND SELECTION AGAINST MIGRANTS IN EVOLUTIONARILY REPLICATED EXTREME ENVIRONMENTS

GENETIC DIFFERENTIATION AND SELECTION AGAINST MIGRANTS IN EVOLUTIONARILY REPLICATED EXTREME ENVIRONMENTS

Functional characterization of evolutionarily divergent 4-coumarate Co A ligases in Rice

Functional characterization of evolutionarily divergent 4-coumarate Co A ligases in Rice