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MOLUSCUM CONTAGIOSUM
Histopathology:At low magnification the "domedpapule" is divided into pearshaped nodules of proliferating
epidermis which on the surfaceappear as volcanic micro craters(arrow 2) separated by theepidermal lips of the crater (arrow1).The characteristic and keyfeature is the presence ofmolluscum bodies also known asHenderson-Patterson bodiesinthe depths of the "volcanos".These bodies appear about 1-2layers above the basal cell layer
(arrow 5) of the epidermis as pinkto red inclusions (arrow 3) andprogress to become large brightred inclusions in the upper layersof the epidermis.Finally, they may exceed the sizeof the original cell (arrows 3 inhigh mag images). The inclusionsdisplace the nucleus and leaveonly a thin crescent of basophilicmaterial. In the granular layer theinclusions at first are surrounded
by blue granules (arrow 4) andeventually may even appearslightly basophilic in the upperlayers.
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The stratum corneum or cornifiedlayer is oftendisintegrated as theinclusions enlarge (arrow 2). Atthe peak the molluscum bodiesmay reach a diameter of 35microns. Ultrastructure shows
each inclusion is composed ofbrick shaped viruses withdumbbell shaped nucleoidssurrounded by the amorphouslayer of capsids
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CARCINOMA PLANOCELLULARE
Keratinized squamous stratified epithelium Basement membrane of the stratified squamousepthelium is penetrated by atypical cells with
invasion to the underlying connective tissue
1. Islands of neoplastic squamous cells2. Keratinous pearls
3. Stroma with immune cells
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CARCINOMA BASOCELLULARE
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NEVUS PIGMENTOSUS
Micro Findings
1. Small nests or bundles of nevuscells in dermis with thinned
overlying epidermis.
2. Nevus cells: (no necessarity to
differentiate these cells described
below).
3. Cuboidal cells with regular,
spheroid, moderately
hyperchromatic nuclei.
Upper: larger cells (type A)
with some multinucleated
giant melanocytes.
Middle: smaller cells (type
B) like lymphocytes.
Lower: spindle shaped
(type C) in neuroid bundles
(presumed schwannian
derivation)
4. No cellular atypia nor junctional
activity.
Junctional activity:
melanocytes proliferation
or dropping off restricted
to basal portion.
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MELANOMA MALIGNA
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