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ANS-Receptors Overview - MIS
Cholinergic Receptors
Nicotinic Muscarinic
GanglionicSkeletalMuscle
NeuronalCNS
Receptors and signal transduction in theANS
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Receptors and signal transduction in the
ANS:Nicotinic Receptors
ACH ACHNa+
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Receptors and signal transduction in the
ANS:Nicotinic Receptors
ACH ACHNa+
NH3
COOH
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Receptors and signal transduction in the
ANS
Cholinergic Receptors
Nicotinic Muscarinic
M1 M5M3 M4M2
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Receptors and signal transduction in theANS:
Muscarinic receptors are 7 transmembrane domain!-protein coupled receptors
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Receptors and signal transduction in the ANS:Muscarinic receptors
"M# M$ M%&
NH3
COOH
Gq
Phospho-
lipase C
(+)
PIP2
IP3
Diacylglycerol
Increase Ca2+ Actiate Protein!inase C
"esponse
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Receptors and signal transduction in theANS:
Muscarinic Receptors(#2 an$ #%)
NH3
COOH
GI
(-)
A&P cA#P
"e$'ce cA#P-Depen$entProtein !inase Actiity
"esponse
A$enylate Cyclase
(+)!+
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Receptors and signal transduction in theANS
Adrenergic Receptors
A
2
*
D
2A
2*
2C
2
3
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Receptors and signal transduction in the ANS:
#-Adrenergic
Receptors
NH3
COOH
Gq
Phospho-
lipase C
(+)
PIP2
IP3 Diacylglycerol
Increase Ca2+ Actiate Protein!inase C
"esponse
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Receptors and signal transduction in the ANS:
'-Adrenergic
Receptors
GI
(-)
A&P cA#P
"e$'ce cA#P-Depen$entProtein !inase Actiity
"esponse
A$enylate Cyclase
(+)!+
NH3
COOH
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Receptors and signal transduction in the ANS:-Adrenergic
Receptors
G
(+)
A&P cA#P
Increase cA#P-Depen$entProtein !inase Actiity
"esponse
A$enylate Cyclase
NH3
COOH
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,ector OrganA$renergic"esponse "eceptor
Cholinergic"esponse "eceptor
Heart"ate o Contraction Increase Decrease #2
.orce o Contraction Increase Decrease #2
.'nctional "esponses #e$iate$ /y the AN
0
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(unctional Responses Mediated b)the ANS
,ector OrganA$renergic"esponse "eceptor
Cholinergic"esponse "eceptor
Arteries (1ost) asoconstriction ---------- --
eins asoconstriction 2 ---------- --
eletal #'scle aso$ilation 2 ---------- --
,n$otheli'1 ---------- -- "elease ,D". #3
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(unctional Responses Mediated b)the ANS
,ector OrganA$renergic"esponse "eceptor
Cholinergic"esponse "eceptor
4'ng
*ronchiolar
s1ooth 1'scle
*roncho$ilation *ronchoconstriction #3
2
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(unctional Responses Mediated b)the ANS
,ector OrganA$renergic"esponse "eceptor
Cholinergic"esponse "eceptor
*la$$er 5all "ela6ation 2 Contraction #37reter Contraction "ela6ation #3phincter Contraction "ela6ation #37ter's (pregnant) "ela6ation 2 aria/le
Penis8as $eerens ,9ac'lation
Genito'rinary0 s1ooth 1'scle
Contraction #3
#3,rection
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(unctional Responses Mediated b)the ANS,ector Organ
A$renergic"esponse "eceptor
Cholinergic"esponse "eceptor
aliary Glan$s Increase secretion
Increase secretion1ooth #'scle:
"ela6ation 2 02 #3
phincters Contraction "ela6ation #3
ecretion ---------- -- Increase secretion #3
Gastrointestinal &ract
#3
;alls Contraction
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(unctional Responses Mediated b)the ANS
,ector OrganA$renergic"esponse "eceptor
Cholinergic"esponse "eceptor
Hair ollicles0
1ooth 1'scle
Contraction0
Piloerection
-------------- --
5eat glan$s&her1oreg'lation Increase secretion
in
----------------#3
Increase secretion Apocrine (stress) ----------------
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(unctional Responses Mediated b)the ANS
,ector OrganA$renergic"esponse "eceptor
Cholinergic"esponse "eceptor
Iris
"a$ial 1'scle Contraction
,ye
----------------
-------------Circ'lar 1'scle #3Contraction--
Ciliary 1'scle
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*h)siolog) o+ the e)e
4ens
Iris
"a$ial1'scle ()
Circ'lar1'scle (#3)
Canal ochle11
&ra/ec'lar
1esh5or
Ciliary
1'scle (#3) Ciliaryepitheli'1 (2)
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*h)siolog) o+ the e)e
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*h)siolog) o+ the e)e
P'pil
Circ'lar 1'scle
(#3 "eceptors)
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*h)siolog) o+ the e)e
P'pil
Contraction o circ'lar1'scle lea$s to
1iosis
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*h)siolog) o+ the e)e
P'pil
Contraction o circ'lar1'scle lea$s to
1iosis
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*h)siolog) o+ the e)e
P'pil
"a$ial #'scle( "eceptors)
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*h)siolog) o+ the e)e
P'pil
Contraction o ra$ial1'scle lea$s to
1y$riasis
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(unctional Responses Mediated b)the ANS
,ector OrganA$renergic"esponse "eceptor
Cholinergic"esponse "eceptor
4ier Glycogenolysis -------------- --
.at cells 4ipolysis -------------- --
!i$ney Increase renin
secretion
-------------- --
Pancreas Decrease ins'linrelease
#eta/olic 'nctions
----------------
03
2
Gl'coneogenesis
02