Detailed Poster List

P-01

Identification and characterization of imidazoles and thienothiazines as selective inhibitors of butyrylcholinesterase D. Karlsson 1; A. Fallarero 1; G. Brunhofer 1; P. Guzik 2; M. Prinz 3; U. Holzgrabe 3; T. Erker 2; P. Vuorela 1 1Åbo Akademi University, Pharmaceutical Sciences, Department of Biosciences, Turku, Finland; 2University of Vienna, Department of Medicinal Chemistry, Vienna, Austria; 3University of Würzburg, Institute of Pharmacy and Food Chemistry, Würzburg, Germany

P-02

In vitro and in silico pharmacological investigations of natural β2-Adrenoceptors agonists Aimun Ahmed AE. ; Arpad Marki ; Robert Gaspar ; George Falkay University of Szeged, Faculty of Pharmacy, Pharmacodynamics and Biopharmacy, Szeged, Hungary

P-03

Novel NSAID semicarbazide derivatives as potential anticancer and anti-inflammatory drugs I Perkovic ; I Butula ; B Zorc Faculty of Pharmacy and Biochemistry, Department of Medicinal Chemistry, Zagreb, Croatia

P-04

Preparation of new NSAID derivatives bearing hydroxysemicarbazide and carbonylhydrazide moiety I Perkovic ; I Butula ; B Zorc Faculty of Pharmacy and Biochemistry, Department of Medicinal Chemistry, Zagreb, Croatia

P-05

Potential antileishmanial activity of three medicinal plants Ali E Eltayeb ; Kamal E. Ibrahim Faculty of Pharmacy, Chemistry, Khartoum, Sudan

P-06

evaluation of gastroprotective and antinociceptive effect of citral Catarine Massucato Nishijima ; Ellen Geraldo Ganev ; Lucia Regina Machado da Rocha ; Clélia Akiko Hiruma Lima UNESP, Physiology, Botucatu, Brazil

P-07

Anti-biofilms compounds against Staphylococcus aureus infections: identification and characterization of hits from a natural derived library J Kujala 1; A Fallarero 1; M Rajaratnam 2; J Yli-Kauhaluoma 2; PM Vuorela 1 1Åbo Akademi University, Department of Biosciences, Pharmaceutical Sciences, Turku, Finland; 2University of Helsinki, Faculty of Pharmacy, Division of Pharmaceutical Chemistry, Helsinki, Finland

P-08

Sinergicity effect of the combination of arecoline and doxorubicin on HeLa cervical cancer cell line Astrid Maruti Universitas Gadjah Mada, Pharmacy, Yogyakarta, Indonesia

P-09

Alteration of cellular uptake of rosiglitazone in insulin resistant HepG2 cells by transfection ADN gene Enkhzaya Davaa ; Jung Jin Lee ; Soon Gil Choi ; Chang-Seon Myung ; Jeong-Sook Park Chungnam National University, College of Pharmacy, Daejeon, Republic of Korea

P-10

UDP-glucuronosyltransferases expression and activity in Caco-2 cells Hongbo Zhang 1; Ari Tolonen 2; Sanna Sissalo 3; Timo Rousu 2; Jouni Hirvonen 3; Moshe Finel 1 1Center for Drug Research, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; 2Novamass Ltd, Oulu, Finland; 3Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

P-11

Determination of some morphological properties of CPPs-Proteins complexes Saman Ahmad Nasrollahi 1; Changiz Taghibiglou 2; Rasoul Dinarvand 1; Effat Sadat Farboud 1; Ebrahim Azizi 3 1School of Pharmacy, Tehran University of Medical, Pharmaceutics, Tehran, Islamic Republic of Iran; 2University of Saskatchewan, Pharmacology, Saskatoon, Canada; 3School of Pharmacy, Tehran University of Medical, Pharmacology and Toxicology, Tehran, Islamic Republic of Iran

P-13

Molecular modelling study of alkylphosphocholines as anti-cancer agents M Malta de Sá ; KFM Pasqualoto ; CO Rangel-Yagui University of São Paulo, Department of Pharmacy, São Paulo, Brazil

P-14

Nonspecific binding in in-vitro studies of drug glucuronidation Nenad Manevski 1; Paolo Svaluo Morelo 2; Jari Yli-Kauhaluoma 1; Moshe Finel 2 1Faculty of Pharmacy, Helsinki University, Division of Pharmacetucal Chemistry, Helsinki, Finland; 2Faculty of Pharmacy, Helsinki University, Centre for Drug Research, Helsinki, Finland

P-15

In vitro cyclooxygenase inhibition by natural quinones and possible mechanism of their action Zsofia Kutil 1; Veronika Temml 2; Premysl Landa 3; Jan Malik 4; Ladislav Kokoska 1; Petr Marsik 3; Daniela Schuster 2; Tomas Vanek 3; Marcela Dvorakova 3 1Czech University of Life Sciences Prague, Institute of Tropics and Subtropics, Department of Crop Sciences and Agroforestry, Prague, Czech Republic; 2University of Innsbruck, Institute of Pharmacy/Pharmaceutical Chemistry, Computer-Aided Molecular Design Group and Center for Molecular Biosciences, Innsbruck, Austria; 3Joint Laboratory of IEB AS CR, v.v.i., and Research Institute of Crop Production, v.v.i., Laboratory of Plant Biotechnologies, Prague, Czech Republic; 4Czech University of Life Sciences Prague, The Faculty of Agrobiology, Food and Natural Resources, Department of Zoology and Fisheries, Prague, Czech Republic

P-16

Two different organic solvents to produce sustained release HPMC microparticles for nasal delivery using co-precipitation technique Issraa Rasheed A. Al-Obaidi ; Howard N. E. Stevens ; Fiona J. McInnes Strathclyde Institute of Pharmacy and Biomedical Sciences, Drug Delivery/ Pharmaceutics, Glasgow, United Kingdom

P-17

Screening of excipients for stabilizing Semliki Forest virus vector during freeze-drying A Kauppinen 1; VP Ruottinen 1; AP Karttunen 1; J Ruotsalainen 2; R Pellinen 2; K Järvinen 1; A Hinkkanen 2; J Ketolainen 1

1University of Eastern Finland, School of Pharmacy, Kuopio, Finland; 2University of Eastern Finland, Department of Biotechnology and Molecular Medicine, Kuopio, Finland

P-18

Production of ibuprofen particles with different shapes Andreia Cordeiro 1; João Sousa 2; João Pinto 1 1iMed.UL - Faculdade de Farmácia, Universidade de Lisboa, Dept. Tecnologia Farmacêutica, Lisboa, Portugal; 2IDMEC - Instituto Superior Técnico, Universidade Técnica de Lisboa, Dept. de Engenharia Mecânica, Lisboa, Portugal

P-19

The applicability of sucrose laurate in hot-melt technology P. Láng 1; A. Szûts 1; R. Ambrus 1; L. Kiss 1; M. A. Deli 2; P. Szabó-Révész 1 1University of Szeged, Pharmaceutical Technology, Szeged, Hungary; 2Institute of Biophysics, Biological Research Center, Hungarian Academy of Sciences, Laboratory of Molecular Neurobiology, Szeged, Hungary

P-20

Effect of formulation variables on physicochemical characteristics of synbiotic microparticles with Lactobacillus casei Tanja Petreska Ivanovska 1; Lidija Petrusevska-Tozi 1; Katarina Smilkov 2; Emil Popovski 3; Anita Grozdanov 4; Nikola Geskovski 1; Rumenka Petkovska 1; Marija Glavas Dodov 1; Kristina Mladenovska 1 1University Ss Cyril and Methodius, Faculty of Pharmacy, Skopje, Macedonia, Fyrom; 2University Goce Delcev, Faculty of Medical Sciences - Pharmacy, Stip, Macedonia, Fyrom; 3University Ss Cyril and Methodius, Faculty of Natural Sciences and Mathematics, Skopje, Macedonia, Fyrom; 4University Ss Cyril and Methodius, Faculty of Technology and Metallurgy, Skopje, Macedonia, Fyrom

P-21

Synthesis and characterization of peg-g-chitosan and their use as nanoparticle delivery system for BSA Sofia A Papadimitriou ; Dimitrios N Bikiaris ; Dimitrios S Achilias Aristotle University of Thessaloniki, Department of Chemistry, Thessaloniki, Greece

P-22

Preparation of amorphous calcium phosphate stabilised by acid hydrolysed carboxy methyl cellulose fractions Mohammed Sabar Al-Lami ; Chris van der Walle ; Clive Wilson University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United Kingdom

P-23

Preparation of positively charged polymeric micelles for nasal administration Emine Kahraman 1; Ayse Karagoz 2; Sevil Dincer 2; Yildiz Ozsoy 1 1Istanbul University, Pharmaceutical Technology, Istanbul, Turkey; 2Yildiz Technical University, Bioengineering, Istanbul, Turkey

P-24

Preparation of fast Disintegrating micro-pellets using ludiflash® and functional additives Simone Schrank ; Petra Heidinger ; Eva Roblegg Karl Franzens University, Graz, Austria, Institute of Pharmaceutical Sciences, Department Pharmaceutical Technology, Graz, Austria

P-25

Development and evaluation of a novel dosage form of diclofenac sodium using ethylene vinyl acetate copolymer and sodium starch glycolate against voltaren® retard (in-vitro/in-vivo study) S Al-Nimry 1; K AlKhamis 1; H Ibrahim 2; M Salem 1 1Jordan University of Science and Technology, Irbid, Jordan; 2ACDIMA, Amman, Jordan

P-26

The use of recrystallization technique for preparation of spherical agglomerates containing disintegrating agent Omid Taghizadeh 1; Maryam Maghsoodi 1; Babak Ardalani 2; Ali Nokhodchi 3 1School of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, pharmaceutics, Tabriz, Islamic Republic of Iran; 2School of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Saghez, Islamic Republic of Iran; 3Medway School of Pharmacy, The Universities of Kent and Greenwich, pharmaceutics, London, United Kingdom

P-27

Development of matrix pellets prepared by extrusion and spheronization of Atenolol and alkalizing component to enhance bioavailability Elnazeer I. Hamedelniel ; Bajdik János ; Klára Pintye-Hódi University of Szeged, Pharmaceutical Technology, Szeged, Hungary

P-28

Particle size reduction of niflumic acid using disintegration and integration methods T. Szunyogh ; R. Ambrus ; P. Szabó-Révész University of Szeged, Department of Pharmaceutical Technology, Szeged, Hungary

P-29

FBRM as a PAT tool for in-line monitoring of particle growth kinetics in wet granulation processes Firas Alshihabi 1; Thierry Vandamme 2; Betz Gabriele 1 1University of Basel, Pharmaceutical Technology, Basel, Switzerland; 2Université de Strasbourg, Faculté de Pharmacie, équipe de Pharmacie Biogalénique, Strasbourg, France

P-30

Poly(vinyl acetat) and polystyrene drug delivery systems for indometacin V. Andonova 1; G. Georgiev 2; V. Toncheva 2; M. Kassarova 1 1Medical University Plovdiv, Faculty of Pharmacy, Department of Pharmaceutical sciences, Plovdiv, Bulgaria; 2Sofia University „St. Kliment Ohridski”, Faculty of Chemistry, Sofia, Bulgaria

P-31

Calcium-stearate micro-pellets: impact of drying on final pellet characteristics Simone Schrank 1; Johannes Khinast 2; Andreas Zimmer 1; Daniela Reischl 3; Eva Roblegg 1 1Karl Franzens University, Graz, Austria, Institute of Pharmaceutical Sciences, Department Pharmaceutical Technology, Graz, Austria; 2Graz University of Technology, Institute for Process and Particle Engineering, Graz, Austria; 3Research Center Pharmaceutical Engineering, Graz, Austria

P-32

Development and validation of a capillary electrophoresis method with capacitively coupled contactless conductivity detection (CE-C4D) for the analysis of Tobramycin and its related impurities Mohamed El-Attug ; Jos Hoogmartens ; Erwin Adams ; Ann Van Schepdael Katholieke Universiteit Leuven, Pharmaceutical Analysis, Leuven, Belgium

P-33

Simultaneous quantification of phosphatidylcholine and cholesterol in liposomes using NIR spectroscopy and chemometry A.S. Porfire ; I. Tomuta ; L. Tefas ; M. Achim ; S.E. Leucuta University of Medicine and Pharmacy „Iuliu Hatieganu”, Department of Pharmaceutical Technology and Biopharmaceutics, Cluj-Napoca, Romania

P-34

Evaluation of chemical stability of fluconazole J.C.R Correa 1; C. Reichman 1; C.D. Vianna-Soares 2; H.R.N. Salgado 1 1Universidade Estadual Paulista - UNESP, Araraquara, Brazil; 2Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil

P-35

High-throughput NIR-chemometric method for chemical and physical characterization of indapamide tablets IOAN TOMUTA 1; Rares Iovanov 1; Lucia Rus 2; Loredana Andreea Vonica 3; Sorin Leucuta 1 1University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Pharmaceutical Technology and Biopharmaceutics, Cluj-Napoca, Romania; 2University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Drug Analysis, Cluj-Napoca, Romania; 3Polipharma INDUSTRIES, Cluj-Napoca, Romania

P-36

Characterization of drug and liposome interactions U Trettenes ; A Bauer-Brandl ; B Klösgen University of Southern Denmark, Department of Physics and Chemistry, Odense, Danmark

P-37

Development and characterization of effective topical liposomal system for localized delivery against cutaneous candidiasis Madhu Gupta ; Suresh P. Vyas Dr. H.S.Gour V.V. Sagar, Department of Pharmaceutical Sciences, Sagar, India

P-38

Biopharmaceutic classification of amlodipine benzylate: solubility determination Rafael Leal Monteiro Paraiso ; Marina de Freitas Silva ; Valentina Porta University of Sao Paulo, Pharmaceutical Sciences, São Paulo, Brazil

P-39

Development of in-silico model by using theoratical and experimental investigations of silicone matrix systems Bergthóra Snorradóttir 1; Rut Gudmundsdóttir 2; Fjóla Jónsdóttir 2; Tryggvi Ólafsson 1; Freygardur Thorsteinsson 3; Palmar Gudnason 3; Már Másson 1 1University of Iceland, Faculty of Pharmaceutical Sciences, Reykjavik, Iceland; 2University of Iceland, Faculty of Industrial Engineering, Mechanical Engineering and Computer Science, Reykjavik, Iceland; 3Össur hf., Reykjavik, Iceland

P-40

Modelling of pharmaceutical tablet swelling and dissolution using discrete element method J Kimber 1; S Kazarian 1; F Stepanek 2 1Imperial College London, Chemical Engineering and Chemical Technology, London, United Kingdom; 2Institute of Chemical Technology, Prague, Czech Republic

P-42

Pharmacokinetic/Pharmacodynamic modeling & simulation of decursin derivative JHL45 for development of anti-atopic dermatitis agent

Dong-hyun Kim 1; In-hwan Baek 2; Jung-woo Chae 1; Gyu-yong Song 1; Kwang-il Kwon 1 1College of pharmacy, Chungnam National University, Daejeon, Republic of Korea; 2Incrementally Modified Drug (IMD), Yuhan research Institute 416-1, Gongse-dong, Giheung-gu, Yongin-si, Gyeonggi-do, Republic of Korea

P-43

Nanosuspensions of poorly soluble drugs for improved dissolution: preparation and development by wet milling Peng Liu 1; Xinyu Rong 2; Johanna Laru 3; Bert Van Veen 3; Juha Kiesvaara 3; Jouni Hirvonen 1; Timo Laaksonen 1; Leena Peltonen 1 1Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; 2Department of Pharmacy, College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China; 3Orion Pharma R&D, Formulation Research, Helsinki, Finland

P-44

Effect of the microspehere production methods on in-vitro particle characteristics: comparison of w/o/w and s/o/w emulsion - solvent evaporation techniques Umut Can Oz ; Kandemir Canefe Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey

P-45

Release profiles of naproxen-loaded, chitosan oligosaccharide treated alginate-microparticles prepared in the two-stage procedure N Cekic 1; B Calija 2; S Savic 2; M Savic 3; J Milic 2 1DCP Hemigal, R&D Sector, Leskovac, Serbia; 2Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Belgrade, Serbia; 3Faculty of Pharmacy, Department of Pharmacology, Belgrade, Serbia

P-46

Raloxifene pharmacogenetics: translation from in vitro to in vivo T Trdan 1; A Mrhar 1; J Trontelj 1; B Stieger 2; A Zavratnik 3; J Marc 4; B Ostanek 4 1University of Ljubljana, Faculty of Pharmacy, Department of Biopharmacy and Pharmacokinetics, Ljubljana, Slovenia; 2University Hospital, Department of Clinical Pharmacology and Toxicology, Zürich, Switzerland; 3University Medical Centre, Department of Endocrinology, Maribor, Slovenia; 4University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Ljubljana, Slovenia

P-47

A quantitative demonstration of heterogeneity between contact and non-contact measurements of tablet height and diameter B.X. Tan ; C.V. Liew ; P.W.S. Heng National University of Singapore, Department of Pharmacy, Singapore, Singapore

P-48

Study of hydration states and water disposition in the piperaquine phosphate hyper-hydrate Mosè Santaniello ; Marco Quaglia ; Grazia Gallo ; Gianandrea Quattrociocchi ; Walter Cabri Sigma-tau, Roma, Italy

P-49

Effect of relative humidity on storage of olanzapine polymorphs Maria Paisana 1; Martin Wahl 2; João Pinto 1 1iMed.UL - Faculdade de Farmácia, Universidade de Lisboa, Tecnologia Farmacêutica, Lisboa, Portugal; 2Eberhard Karls Universitaet Tuebingen, Pharmazeutisches Institut, Tuebingen, Germany

P-50

Amorphous form in the pharmaceutical technological research Cs. Mártha ; O. Jójárt-Laczkovich ; P. Szabó-Révész University of Szeged, Pharmaceutical Technology, Szeged, Hungary

P-51

Thermally processed solid dispersions of Griseofulvin in Eudragit® L100-55 as an approach for solubility enhancement R Bennett 1; J Hughey 1; J Keen 1; C Brough 2; J McGinity 1 1University of Texas at Austin, Pharmaceutics, Austin, Texas, United States; 2DisperSol Technologies, Austin, Texas, United States

P-52

Formulation of Eudragit EPO coated Ibuprofen sodium - comparative properties between fluid bed and spray drying techniques Dejan Kostovski 1; Nikola Geskovski 2; Marija Glavas Dodov 2; Liljana Krsteska 1; Sonja Ugarkovic 1 1Alkaloid AD, Research & Development, Skopje, Macedonia, Fyrom; 2Faculty of Pharmacy, Center for Pharmaceutical Nanotechnology, Skopje, Macedonia, Fyrom

P-53

Preparation and Characterization of Self Emulsifying Drug Delivery System for water insoluble compound A G Agrawal 1; Kumar Ashok 1; P S Gide 2 1Cachet Pharmaceuticals Pvt. Ltd.,Alkem group, INDIA, Formulation Research and Development, Bhiwadi, Near New Delhi, India; 2MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik – 422 003, India., Principal, Nashik, India

P-54

Studies on novel sustained release quetiapine fumarate from matrix tablet formulations Deepak Sahu Geetnjali Institute of Pharmacy, Pharmaceutics, Udaipur, India

P-55

Development of temozolomide dry powders for inhalation for the treatment of lung tumours Nathalie Wauthoz 1; Philippe Deleuze 1; Amandine Saumet 1; Christophe Duret 1; Robert Kiss 2; Karim Amighi 1 1Université Libre de Bruxelles, Laboratory of Pharmaceutics and Biopharmaceutics, Brussels, Belgium; 2Université Libre de Bruxelles, Laboratory of Toxicology, Brussels, Belgium

P-56

Production, characterization and in vitro deposition of budesonide loaded poly(lactic acid) nanoparticles for nebulization Mohammad Ali Amini 1; Amir Amani 2; Elina Esmaeilzadeh_Gharedaghi 2; Mohammad Ali Faramarzi 3 1Islamic Azad University, Karaj branch; Young Researchers Club, Department of Microbiology, Karaj, Islamic Republic of Iran; 2Tehran University of Medical Sciences, Department of medical Nanotechnology, Tehran, Islamic Republic of Iran; 3University of Medical Sciences, Department of Pharmaceutical Biotechnology, Tehran, Islamic Republic of Iran

P-57

Improving pharmaceutical performance of spray dried powders by using nano particle additives J Hellrup 1; J Hellrup 1; G Alderborn 1; G Alderborn 1; D Mahlin 1; D Mahlin 1 Uppsala University, Deparment of Pharmacy, Uppsala, Sweden

P-58

Validation of the bronchial epithelial cell line, VA10, as a permeation enhancer model for N,N,N-trimethyl chitosan B.E. Benediktsdottir 1; A.J. Arason 2; Th. Gudjonsson 2; M. Masson 1; O. Baldursson 3 1University of Iceland, Faculty of Pharmaceutical Sciences, Reykjavik, Iceland; 2University of Iceland, Stem Cell Research Unit, Biomedical Center, Reykjavik, Iceland; 3Landspitali University Hospital, Chief Medical Executive, Reykjavik, Iceland

P-59

Formulation of solid lipid microparticles as system for pulmonary administration using a supercritical fluid process A Berton ; G Piel ; B Evrard ; A Gillet University of Liege, Laboratory of Pharmaceutical Technology, Liège, Belgium

P-60

Chitosan and its trimethyl derivative as a carrier for mucosal virus delivery in guinea pig Mohammad Ali Amini 1; Ali Rezaei Mokarram 2; Farzaneh Tajdini 3; Morteza Taghizadeh 2; Hamideh Amini 4 1Islamic Azad University, Karaj branch; Young Researchers Club, Department of Microbiology, Karaj, Islamic Republic of Iran; 2Razi Vaccine and Serum research Institute, Department of Biotechnology, Karaj, Islamic Republic of Iran; 3Islamic Azad University, Karaj branch, Department of Microbiology, Karaj, Islamic Republic of Iran; 4Islamic Azad University, North Tehran branch, Department of Microbiology, Tehran, Islamic Republic of Iran

P-61

Nanoparticle vaccine against Shigella flexneri in mice A.I. Camacho 1; J. De Souza 1; S. Sanchez-Gomez 1; J.M. Irache 2; C. Gamazo 1 1University of Navarra, Microbiology, Pamplona, Spain; 2University of Navarra, Pharmacy and Pharmaceutical Technology, Pamplona, Spain

P-62

Evaluation of a mucosal vaccine of Streptococcus equi antigens encapsulated in liposomes L. Figueiredo ; A. Cadete ; L.M.D. Gonçalves ; M.L. Corvo ; A.J. Almeida iMed.UL – Research Institute for Medicines and Pharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal

P-63

Topical application of liposomes: parameters influencing their effectiveness A Gillet 1; F Lecomte 1; P Hubert 2; Ph Compère 3; B Evrard 1; G Piel 1 1University of Liège, Pharmacy, Liège, Belgium; 2University of Liège, Giga-Cancer, Liège, Belgium; 3University of Liège, Sciences and Environmental Management, Liège, Belgium

P-64

Sustained release from HPMC/metformin microparticles for nasal delivery, manufactured using an aqueous-organic precipitation technique Issraa Rasheed A. Al-Obaidi 1; Howard N. E. Stevens 2; Fiona J. McInnes 2 1Strathclyde Institute of Pharmacy and Biomedical Sciences, Drug Delivery/ Pharmaceutics, Glasgow, United Kingdom; 2Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), Drug Delivery/ Pharmaceutics, Glasgow, United Kingdom

P-65

Liposomal mupirocin: on the way to improved wound and burns therapy J. Hurler ; O.A. Berg ; M. Skar ; A.H. Conradi ; P.J. Johnsen ; N. Skalko-Basnet University of Tromsø, Pharmacy, Tromsø, Norway

P-66

Formulation of a sunscreen product using β-cyclodextrine and evaluation of its penetration through rat skin Farhad Kiafar ; Javad Shokri ; Mohammad Reza Siahi ; Hadi Valizadeh ; Mina Dizaji Tabriz University of Medical Sciences, Department of Pharmaceutics, Tabriz, Islamic Republic of Iran

P-67

Optimisation of the pharmaceutical characteristics of mucoadhesive buccal gels based on thermosensitive polymers for the treatment of alveolar osteitis E. Dinte ; I. Tomuta ; R.I. Iovanov ; E. Mut ; S.E. Leucuta Iuliu Hatieganu University, Pharmaceutical Technology and Biopharmaceutics, Cluj-Napoca, Romania

P-68

Desing and evaluation of chitosan buccal discs Gulin Amasya ; Tangul Sen ; Nilufer Tarimci Ankara University Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey

P-69

Optimization of silicone drug delivery matrix with experimental design and in vitro transdermal permeations studies Bergthóra Snorradóttir 1; Freygardur Thorsteinsson 2; Palmar Gudnason 2; Már Másson 1 1University of Iceland, Faculty of Pharmaceutical Sciences, Reykjavik, Iceland; 2Össur hf., Reykjavik, Iceland

P-70

Transport studies of polystyrene nanoparticles across the buccal mucosa Birgit Teubl 1; Eleonore Fröhlich 2; Andreas Zimmer 1; Eva Roblegg 1 1Karl Franzens University, Graz, Austria, Institute of Pharmaceutical Sciences, Department Pharmaceutical Technology, Graz, Austria; 2Medical University of Graz, Austria, Center for Medical Research, Graz, Austria

P-71

Niosomes as a potential ocular delivery system for the opioid growth factor antagonist –naltrexone hydrochloride : influence of vesicular encapsulation on photoxidation R G Alany ; H Abdelkader ; Z Wu ; R Al-Kassas University of Auckland, School of Pharmacy, Auckland, New Zealand

P-72

Thermoreversible in situ gelling solutions for ophthalmic delivery of pilocarpine hydrochloride Yagiz Anasiz 1; Berrin Kucukturkmen 2; Asuman Bozkir 2 1Ankara University Faculty of Pharmacy, Ankara, Turkey; 2Ankara University Faculty of Pharmacy, Pharmaceutical Technology, Ankara, Turkey

P-73

Optimized ophthalmic phase transforming hydrogel and evaluation Vinod Singh 1; S. Appala Raju 2; S. Sharan Bushetti 3; Rizwan Ahmad 4; Mamta Farswan Singh 5 1Sardar Bhagwan Singh PG Institute of biomedical Sciences and Research, Department of Pharmaceutics, Dehradun, India; 2HKEs college of pharmacy, Department of Pharmaceutical Chemistry, Gulbarga, India; 3HKEs college of pharmacy, Department of Pharmaceutics, Gulbarga, India; 4Oman Medical College, Department of Human Functioning, Sohar, Oman; 5Sardar Bhagwan Singh PG Institute of biomedical Sciences and Research, Department of Pharmacology, Dehradun, India

P-74

Evaluation of mucoadhesive ocular inserts in a model of corneal lesion in albino rabbit: a preliminary study

Nadia Nicosia ; E Egiziano ; G Doveri ; S Tampucci ; S Burgalassi ; D Monti ; P Chetoni University of Pisa, Pharmaceutical Sciences, Pisa, Italy

P-75

Spatial variation in the viscoelastic properties of the vitreous humour: impact on ocular drug delivery L E Tan 1; F Watts 2; A Wright 2; M Tassieri 3; J Girkin 4; C Wilson 1 1University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United Kingdom; 2University of Strathclyde, Institute of Photonics, SUPA, Glasgow, United Kingdom; 3University of Glasgow, Division of Biomedical Engineering, School of Engineering, Glasgow, United Kingdom; 4University of Durham, Department of Physics, Durham, United Kingdom

P-76

Determination of factors affecting the chitosan nanoparticles size produced by sonication method using Artificial Neural Networks (ANNs) Elina Esmaeilzadeh-Gharedaghi 1; Amir Amani 1; Mohammad Ali Amini 2; Mohammad Ali Faramarzi 3 1Tehran University of Medical Sciences, Department of Medical Nanotechnology, Tehran, Islamic Republic of Iran; 2Islamic Azad University, Karaj branch; Young Researchers Club, Department of Microbiology, Karaj, Islamic Republic of Iran; 3Tehran University of Medical Sciences, Department of Pharmaceutical Biotechnology, Tehran, Islamic Republic of Iran

P-78

Development of finasteride liquid crystalline nanoparticles for the topical application: preparation, characterization and in-vitro release study Rengarajan Baskaran ; Thiagarajan Madheswaran ; Raj Kumar Thapa ; Chul-Soon Yong ; Bong-Kyu Yoo yeungnam University, Pharmacy, Gyeongsangbuk-Do, Republic of Korea

P-81

Characterization of labelled fluorescent nanoparticles for SiRNA delivery C. Zandanel ; C. Vauthier Univ Paris-Sud, Physico-chimie, Pharmacotechnie, Biopharmacie. CNRS, UMR 8612, Chatenay Malabry, France

P-82

Photoluminescent diamond nanoparticles as vectors for short nucleic acids delivery in cells, in the context of Ewing Sarcoma disease Anna Alhaddad 1; Géraldine Dantelle 2; Marie-Pierre Adam 3; Christelle Mansuy 4; Claude Malvy 1; François Treussart 3; Jean-Rémi Bertrand 1 1CNRS UMR 8203, CNRS, Villejuif, France; 2laboratoire de physique de la matière condensée, Ecole polytechnique, Palaiseau, France; 3UMR 8537, Ecole Normale Supérieure de Cachan, Cachan, France; 4CNRS UMR 7613, Paris, France

P-83

SPIONs-loaded PLGA nanoparticles: formulation, characterization and in vitro evaluation on Caco-2 and T47-D cells Kocbek Petra 1; Plemenitaš Marjetka 1; Kralj Slavko 2; Makovec Darko 2; Kristl Julijana 1 1UL - Faculty of Pharmacy, Pharmaceutical Technology, Ljubljana, Slovenia; 2Jožef Stefan Institute, Ljubljana, Slovenia

P-84

Formulation of solid lipid nanoparticles with resveratrol for treatment of rheumatoid arthritis J Pelipenko ; K Teskac Plajnsek ; J Kristl University of Ljubljana, Faculty of Pharmacy, Pharmaceutical technology, Ljubljana, Slovenia

P-85

Development of a mucoadhesive nanoparticulate drug delivery system for a targeted drug release in the bladder Jan Barthelmes ; Glen Perera ; Juliane Hombach ; Sarah Dünnhaupt ; Andreas Bernkop-Schnürch University of Innsbruck, Pharmaceutical Technology, Innsbruck, Austria

P-86

Development of Dexamethasone-loaded Nanostructured Lipid Carriers (NLC) for Nebulization S. Weber 1; J. Pardeike 2; H.P. Zarfl 3; A. Zimmer 2 1Research Center Pharmaceutical Engineering GmbH, Graz, Austria; 2Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Graz, Austria; 3Private Veterinary Surgery, Wolfsberg, Austria

P-87

Enhanced anti tumoral activity of methotrexate-human serum albumin conjugated nanoparticles by targeting with LHRH peptide Azade Taheri 1; Rassoul Dinarvand 1; Fatemeh Atyabi 1; Fatemeh Ahadi 1; Atefe Taheri 2; Pooria Mansoori 3 1Tehran University of Medical Sciences, Faculty of Pharmacy, Department of Pharmaceutics, Tehran, Islamic Republic of Iran; 2Tehran University of Medical Sciences, Faculty of Dentistry, Department of Pathology, Tehran, Islamic Republic of Iran; 3Jondishapour University of Medical Sciences, Faculty of Medicine, Deparment of Radiology, Ahwaz, Islamic Republic of Iran

P-88

Effects of Raloxifene on matrix synthesis of osteoarthritis-like chondrocytes Aysegul Kavas 1; Seda Tuncay 2; Dilek Keskin 1; Sreeparna Banerjee 2; Aysen Tezcaner 1 1Middle East Technical University, Department of Engineering Sciences, Ankara, Turkey; 2Middle East Technical University, Department of Biological Sciences, Ankara, Turkey

P-89

Chitosan oleate micelles intended for the tretment of infected wounds M.C. Bonferoni ; G. Sandri ; E. Dellera ; S. Rossi ; F. Ferrari ; M. Mori ; C. Caramella University of Pavia, Department of drug sciences, Pavia, Italy

P-90

Inkjet printing of pharmaceuticals Natalja Genina 1; Niklas Sandler 1; Anni Määttänen 2; Petri Ihalainen 2; Leif Kronberg 3; Axel Meierjohann 3; Tapani Viitala 4; Jouko Peltonen 2 1Åbo Akademi University, Department of Biosciences, Turku, Finland; 2Åbo Akademi University, Center for Excellence for Functional Materials, Laboratory of Paper Coating and Converting, Turku, Finland; 3Åbo Akademi University, Laboratory of Organic Chemistry, Turku, Finland; 4University of Helsinki, Faculty of Pharmacy, Division of Biopharmaceutics and Pharmacokinetics, Turku, Finland

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Rheological properties of polymer solutions and their correlation to nanofiber formation by electrospinnig R Rosic ; J Pelipenko ; S Baumgartner ; J Kristl University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ljubljana, Slovenia

P-93

Effects of doxycycline delivery from PCL microspheres in a three-dimensional culture Ozlem Aydin ; Aysen Tezcaner ; Dilek Keskin Middle East Technical University, Department of Engineering Sciences, Ankara, Turkey

P-94

Influences of excipients on properties of immunoglobulin G loaded poly (ε-caprolactone) microspheres O Erdemli ; D Keskin ; A Tezcaner Middle East Technical University, Engineering Sciences, Ankara, Turkey

P-96

A thermosensitive PluronicF 127-based hydrogel for buccal delivery of paclitaxel Soon Gil Choi 1; Eun Jeong Baek 2; Enkhzaya Davaa 1; Kang Moo Huh 2; Jeong-Sook Park 1 1Chungnam National University, College of Pharmacy, Daejeon, Republic of Korea; 2Chungnam National University, Department of Polymer Science and Engineering, Daejeon, Republic of Korea

P-97

Antioxidant activity of citrullus lanatus seeds (watermelon seeds) Gurpreet Singh Bal 1; Naresh Singh Gill 1; Raman Kumar 2 1Rayat Institute of Pharmacy, Pharmacy, Shaheed Bhagat Singh Nagar (Punjab), India; 2Rayat Institute of Pharmacy, Pharmacy, Shaheed Bhagat Singh Nagar(PB), India

P-98

Preparation and stability of spray-dried SLNs for local colon delivery of Budesonide H Litovin 1; K Goracinova 1; N Geskovski 1; M Simonoska Crcarevska 1; K Mladenovska 1; M Glavas Dodov 2 1Faculty of Pharmacy, Institute of Pharmaceutical Technology, Skopje, Macedonia, Fyrom; 2Faculty of Pharmacy, Center of Pharmaceutical Nanotechnology, Skopje, Macedonia, Fyrom

P-99

Investigation of antiproliferative effect of estrone-16-oxime ethers in vitro Á. Berényi 1; Gy. Schneider 2; J. Wölfling 2; I. Ocsovszki 3; I. Zupkó 1 1University of Szeged, Department of Pharmacodynamics and Biopharmacy, Szeged, Hungary; 2University of Szeged, Department of Organic Chemistry, Szeged, Hungary; 3University of Szeged, Department of Biochemistry, Szeged, Hungary

P-100

Newly synthesized fluocinolone acetonide C-21 esters: Kinetics of solvolysis and correlation between solvolytic rate constants and carbonyl carbon charges B Markovic 1; V Dobricic 1; S Vladimirov 1; O Cudina 1; V Savic 2; K Karljikovic-Rajic 3 1Faculty of Pharmacy, University of Belgrade, Department of Pharmaceutical Chemistry, Belgrade, Serbia; 2Faculty of Pharmacy, University of Belgrade, Department of Organic Chemistry, Belgrade, Serbia; 3Faculty of Pharmacy, University of Belgrade, Department of Analytical Chemistry, Belgrade, Serbia

P-101

Pegylated self- assembling nanoparticles as carriers of contrast agents Mohammad Othman 1; Didier Desmaele 1; Patrick Couvreur 1; Philippe Durand 2; Ruxandra Gref 1 1UMR CNRS 8612, Chatenay Malabry, France; 2ICSN, GIF Sur Yvette, France

P-102

New tricyclic pyrazole derivatives as CB1 antagonists having improved activity toward food intake and weight control Paolo Lazzari 1; Andrea Mastinu 2; Marilena Pira 3; Luca Pani 3; Gabriele Murineddu 4; Gerard-Aime Pinna 4; Marilena Pira 5; Andrea Mastinu 6 1Universita' Di Sassari; Neuroscienze Pharmaness Scarl; Kemotech Srl, Pula (CA), Italy; 2Neuroscienze Scarl; CNR-IFT, Pula (CA), Italy; 3CNR-IFT, U.O.S. Cagliari, Pula (CA), Italy; 4Universita' Di Sassari, Scienze del Farmaco, Sassari, Italy; 5Universita' Di Sassari; Pharmaness Scarl; CNR-IFT, Pula (CA), Italy; 6Pharmaness Scarl; CNR-IFT, Pula (CA), Italy

P-103

Preparation and biopharmaceutical evaluation of tacrolimus loaded biodegradable nanoparticles for liver targeting S. Tammam 1; S Mathur 2; N. Afifi 3 1German University in Egypt (GUC), Pharmaceutical Technology, Cairo, Egypt; 2Faculty of Mathematics and Natural Sciences, University of Cologne, Institute of Inorganic Chemistry, Cologne, Germany; 3German University in Cairo (GUC), Pharmaceutical Technology, Cairo, Egypt

P-104

Poly (Propylene Imine) (PPI) dendrimer mediated targeted lung delivery of anticancer bioactive D. Kurmi Balak ; Gajbhiye Virendra ; Gupta Umesh ; K. Jain Narendra Dr. H. S. Gour University, Sagar, Dept. of Pharm. Science, Sagar, India

P-105

Artemisinin-loaded liposomes towards free artemisinin: improved pharmacokinetic profile and antimalarian activity Benedetta Isacchi 1; Silvia Arrigucci 1; Alessia Pietretti 2; Giancarlo la Marca 1; Maria Giuliana Vannucchi 1; Carlo Severini 2; Andrea Novelli 1; Maria Camilla Bergonzi 1; Anna Rita Bilia 1 1University of Florence, Florence, Italy; 2Istituto Superiore di Sanità, Rome, Italy

P-106

Transferrin conjugated liposomes for Artemisinin delivery to cancer cells: enhanced selectivity and activity Chiara Righeschi ; Maria Camilla Bergonzi ; Benedetta Isacchi ; Anna Rita Bilia University of Florence, Sesto Fiorentino (Florence), Italy

P-107

Spray-dried microspheres as controlled release systems for oral delivery of thymol Giovanna Rassu ; Maria Nieddu ; Gianpiera Spada ; Giampiero Boatto ; Elisabetta Gavini University of Sassari, Department of Drug Sciences, Sassari, Italy

P-108

Design and characterization of cetuximab immunonanoparticles prepared using a novel linker molecule N. Karra 1; T. Nassar 1; J. Borlak 2; S. Benita 1 1The Institute for Drug Research of the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel; 2Fraunhofer Institute of Toxicology and Experimental Medicine, Center of Pharmacology and Toxicology,Medical School of Hannover, Hannover, Germany

P-109

Evaluation of anionic half generation 3.5-6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drugs cisplatin G.J Kirkpatrick 1; O.B. Sutcliffe 1; D.J. Flint 2; J.A. Plumb 3; N.J. Wheate 2 1University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United Kingdom; 2University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United Kingdom; 3The Beatson Institute for Cancer Research, Glasgow, United Kingdom

P-110

Preliminary evaluation of liposomes radiolabeled with 159Gd as therapeutic radiopharmaceutical Daniel Soares 1; Mônica de Oliveira 1; Valbert Cardoso 2; Gilson Ramaldes 1 1Universidade Federal de Minas Gerais, Produtos Farmacêuticos, Belo Horizonte, Brazil; 2Universidade Federal de Minas Gerais, Análises Clínicas e Toxicológicas, Belo Horizonte, Brazil

P-111

Liposomes radiolabeled with 159Gd: In vitro cytotoxity activity and scintigraphic image in tumor bearing mice Daniel Soares 1; Mônica de Oliveira 1; Valbert Cardoso 2; Gilson Ramaldes 1 1Universidade Federal de Minas Gerais, Produtos Farmacêuticos, Belo Horizonte, Brazil; 2Universidade Federal de Minas Gerais, Análises Clínicas e Toxicológicas, Belo Horizonte, Brazil

P-112

Decrease in nocifensive behavior in rats after treatment with the EAAT-2 transporter inducer, ceftriaxone L Eljaja 1; O. J. Bjerrum 1; P.H. Honnoré 1; A Nejadi 1; B Abramsen 2 1University of Copenhagen, Pharmacology and Pharmacotherapy, Copenhagen, Danmark; 2University of Copenhagen, Medicinal Chemistry, Copenhagen, Danmark

P-113

The alteration of the aquaporin receptors in the late pregnant rat uterus and preterm delivery E. Ducza ; AB. Seres ; R. Gáspár ; G. Falkay University of Szeged, Department of Pharmacodynamics and Biopharmacy, Szeged, Hungary

P-114

Building new ligands for β2 adrenergic receptor with AutoGrow Árpád Márki University of Szeged, Department of Pharmacodynamics and Biopharmacy, Szeged, Hungary

P-115

New glutamic acid-based MurD ligase inhibitors as potential antibacterial agents Tihomir Tomašiæ ; Roman Šink ; Andreja Kovaè ; Stanislav Gobec ; Anamarija Zega ; Danijel Kikelj ; Lucija Peterlin Mašiè University of Ljubljana, Faculty of Pharmacy, Pharmaceutical chemistry, Ljubljana, Slovenia

P-116

Population pharmacodynamic modelling and simulation as a method to characterize drug combination effects in a rat model of neuropathic pain A. Folkesson 1; P.H. Honoré 1; O.J. Bjerrum 1; K. Kristensen 2 1University of Copenhagen, Pharmacology and Pharmacotherapy, Copenhagen, Danmark; 2AstraZeneca, Clinical Pharmacology, Lund, Sverige

P-117

Eudragit coated hydro-gel beads for delivery of bioactive agents to the duodenum Per I.O. Wikström 1; Tobias Bramer 1; Lilyan Yachoh 2 1Recipharm AB, Pharmaci, Solna, Sweden; 2Uppsala University, Pharmacy, Uppsala, Sweden

P-118

Efficacy of PLGA particles as adjuvants in cancer vaccination: influence of particle size and CpG co-delivery C Arandia ; JM Irache ; S Espuelas University of Navarra, Pharmacy and Pharmaceutical Technology, Pamplona, Spain

P-119

Flow properties of ramipril granules: effect of granule size and lubricant type Buket Aksu Santa Farma Drug Company, Regulatory Affairs, Istanbul, Turkey

P-120

Predicting the effect of interleukin-6, an inflammatory cytokine, on time-dependent reduction of cyclosporine clearance: An application of the Simcyp Population-based Simulator to suppression of CYP450 by biologics Machavaram Krishna K 1; Almond Lisa M 1; Jamei Masoud 2; Rostami-Hodjegan Amin 3 1Simcyp Limited, Sheffield, United Kingdom; 2Simcyp Limited, Sheffield, United Kingdom; 3Simcyp Limited and The University of Manchester, Sheffield / Manchester, United Kingdom

P-121

prediction of drug interaction with investigational drugs Jung-woo Chae ; Dong-hyun Kim ; Jung-hwa An ; Kwang-il Kwon College of pharmacy, Chungnam National University, Daejeon, Republic of Korea

P-122

Robustness evalution in reversed phase liquid cromatography method for the quantitation of methotrexate using Youden's test E.S. Von Zuben ; A.G. Oliveira ; M. Chorilli ; M.V. Scarpa School of Pharmaceutical Sciences - UNESP, Drugs and Pharmaceuticals, Araraquara - SP, Brazil

P-123

Stress degradation study on methotrexate in reversed-phase liquid chromatography methody M. Chorilli ; E. Von Zuben ; A.G. Oliveira ; M.V. Scarpa School of Pharmaceutical Sciences - UNESP, Drugs and Pharmaceuticals, Araraquara - SP, Brazil

P-124

Co-micronisation scale-up study of poorly water-soluble pharmaceutical API: from Precellys-24 to laboratory ball mill A Colin 1; J Hecq 1; L Camus 1; S Cuart 2; M Galiay 3; L Grislain 3 1Bertin Pharma, Formulation and process, Artigues-Près-Bordeaux, France; 2Bertin Pharma, Analytical, Artigues-Près-Bordeaux, France; 3Bertin Pharma, Artigues-Près-Bordeaux, France

P-125

Sources of inter-individual variability in IVIVE of clearance. An investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model H Cubitt 1; K Rowland-Yeo 1; E Howgate 2; A Rostami-Hodjegan 3; Z Barter 4 1Simcyp Ltd, Sheffield, United Kingdom; 2University of Manchester, Manchester, United Kingdom; 3Simcyp Ltd and University of Manchester, Sheffield, United Kingdom; 4Simcyp Ltd and University of Sheffield, Sheffield, United Kingdom

P-126

The signaling pathways of nociceptin and nocistatin in the pregnant human and rat uterine contractility BH Deak 1; A Klukovits 1; E Ducza 1; Zs Kormanyos 2; A Pal 2; G Falkay 1; R Gaspar 1 1University of Szeged, Faculty of Pharmacy, Department of Pharmacodynamics and Biopharmacy, Szeged, Hungary; 2University of Szeged, Faculty of General Medicine, Department of Obstetrics and Gynecology, Albert Szent-Györgyi Clinical Center, Szeged, Hungary

P-127

New 3-hydroxy quinolinone derivatives with promising anticancer activity: the challenges of aqueous formulations M. di Cagno 1; J. Styskala 2; J. Hlaváè 2; M. Brandl 1; A. Bauer-Brandl 1; N. Skalko-Basnet 3 1University of Southern Denmark, IFK, Odense, Danmark; 2Palacky University, Organic Chemistry, Olomouc, Czech Republic; 3University of Tromsø, Pharmacy, Tromsø, Norway

P-128

Water dispersible multilayer tablet for paediatric and adult administration F Elbaz 1; J Chan-Sew 2; M-C Math 2; L Boilait 3 1Sanofi-Aventis, Pharmaceutical Sciences, Montpellier, France; 2Sanofi-Aventis R&D, Pharmaceutical Sciences, Montpellier, France; 3Sanofi-Aventis R&D, Analytical Sciences, Montpellier, France

P-129

Application of chemoinformatics to assist drug discovery of butyrylcholinesterase inhibitors A. Fallarero 1; G. Brunhofer 1; D. Karlsson 1; J. Isojärvi 1; J. Lehtonen 2; T. Erker 3; P. Vuorela 1 1Åbo Akademi University, Pharmaceutical Sciences, Department of Biosciences, Turku, Finland; 2Åbo Akademi University, Biochemistry, Department of Biosciences, Turku, Finland; 3University of Vienna, Department of Medicinal Chemistry, Vienna, Austria

P-130

Structure-activity studies of some novel glutathione peroxidase mimics J Paul Fawcett 1; Bettina Zadehvakili 1; Greg I Giles 2 1University of Otago, School of Pharmacy, Dunedin, New Zealand; 2University of Otago, Department of Pharmacology, Dunedin, New Zealand

P-131

Caco-2 cells cytotoxicity of nifuroxazide derivatives with potential activity against multirresistant Staphylococcus aureus (MRSA) M. B. Fernandes 1; J. E. Gonçalves 1; A. A. Oliveira 2; R. C. T. Garcia 3; T. Marcourakis 3; L. C. Tavares 2; S. Storpirtis 1 1University of São Paulo, Pharmacy Department, Sao Paulo, Brazil; 2University of São Paulo, Biochemical and Pharmaceutical Technology Department, Sao Paulo, Brazil; 3University of Sao Paulo, Clinical Analysis Department, Sao Paulo, Brazil

P-132

Stability and efficacy of ex tempore prepared 5% dapson gel formulations in community pharmacies M. Gajdas ; N. Zivanovic ; N. Dragicevic-Curic Apoteka “Beograd”, Belgrade, Serbia

P-133

The effect of microemulsion formulations containing different surfactants on intestinal permeability of imatinib mesylate through Caco-2 cells Evren Gundogdu 1; Yesim Karasulu 1; Cinel Koksal 2; Ercument Karasulu 2 1Ege University Faculty of Pharmacy, Izmir, Turkey; 2Ege University Center For Drug Research and Development and Pharmacokinetic Application, Izmir, Turkey

P-134

Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides form the flowers of Verbascum mucronatum Lam C. Kahraman 1; Z.S. Akdemir 1; I.I. Tatli 2; E. Kupeli Akkol 3; I. Pesin Suntar 3; H. Keles 4 1Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey; 2Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Ankara, Turkey; 3Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey; 4Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pathology, Afyon, Turkey

P-135

ECC-1 cell based bioassay as a sensitive and rapid screening method for compounds targeting estrogen receptors

Y Konkol ; J Seppänen ; R Kytömaa ; H Vuorikoski ; J Halleen Pharmatest Services Ltd, Turku, Finland

P-136

Tissue distribution of imipramine and its metabolites using MALDI-Imaging Andrew McEwen 1; Daniel Scott 1; Jenny Avery 1; Karen Dummer 1; Malcolm Clench 2 1Quotient Bioresearch, Metabolism, Rushden, United Kingdom; 2Sheffield Hallam University, Biomedical Research Centre, Sheffield, United Kingdom

P-137

in vivo evaluation of mucoadhesive buccal tablets of piroxicam on human healthy volunteers Ali Rýza Kepsutlu 1; Ayhan Savaser 1; Cetin Tas 1; Yalcin Ozkan 1; Tamer Baykara 2 1Gulhane Military Medical Academy, Pharmaceutical Technology, Ankara, Turkey; 2Faculty of Pharmacy, Ankara University, Pharmaceutical Technology, Ankara, Turkey

P-138

Solid dispersions of simvastatin in polyethyleneglycol and parafin Ricardo G. Simões 1; João F. Pinto 2; Manuel E. Minas da Piedade 1 1Faculdade de Ciências, Universidade de Lisboa, Dept. Química e Bioquímica, Lisboa, Portugal; 2iMed.UL - Faculdade de Farmácia, Universidade de Lisboa, Dept. Tecnologia Farmacêutica, Lisboa, Portugal

P-139

Development of a time-delayed release sleep tablet AB Mullen 1; SJ Eccleston 2; LA Hodges 3; VE Ronaldson 3; KA Sime 3; D Pecek 3; HNE Stevens 1 1Drug Delivery International Ltd, Glasgow, United Kingdom; 2Strathclyde Institute of Pharmacy and Biomedical Science, Glasgow, United Kingdom; 3Bio-Images Research Ltd, Glasgow, United Kingdom

P-140

Uterus-relaxing effect of β2-agonists in combination with phosphodiesterase inhibitors: studies on pregnant rat in vivo and on human myometrium in vitro. J Verli 1; A Klukovits 1; Zs Kormanyos 2; J Hajagos-Tóth 1; E Ducza 1; G Falkay 1; A Pal 3; R Gaspar 1 1University of Szeged, Faculty of Pharmacy, Department of Pharmacodynamics and Biopharmacy, Szeged, Hungary; 2University of Szeged, Faculty of General Medicine, Department of Obstetrics and Gynecology, Albert Szent-Györgyi Clinical Center, Szeged, Hungary; 3University of Szeged, Faculty of General Medicine, Department of Obstetrics and Gynecology, Albert Szent-Györgyi Clinical Center, Szeged, Hungary

P-141

Study on interaction of oxytocin with divalent metal ions in aqueous buffered solution Christina Avanti 1; Alexej Kedrov 2; Wouter L.J. Hinrichs 1; Henderik W. Frijlink 1 1University of Groningen, Department of Pharmaceutical Technology and Biopharmacy, Groningen, Netherlands; 2University of Groningen, Department of Molecular Microbiology, Groningen, Netherlands

P-142

Biosurfactant produced by the dematiaceous fungus, Exophiala dermatitidis SK80, exhibited anticancer activity against cancer cell lines Paramaporn Chiewpattanakul 1; Sirinet Phonnok 2; Alain Durand 3; Emmanuelle Marie 3; Benjamas Thanomsub Wongsatayanon 2 1Srinakharinwirot University, Stomatology, Bangkok, Thailand; 2Srinakharinwirot University, Microbiology, Bangkok, Thailand; 3Laboratoire de Chimie Physique Macromoléculaire CNRS-Nancy University, ENSIC, Nancy, France

P-143

Fibronectin fragments with increased surface stability for cell adhesion L McIntosh ; T Zhang ; C.F. van der Walle University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United Kingdom

P-144

Anticancer property of monoolein isolated from yeast and its molecular target on apoptosis induction in human cancer cell lines Sirinet Phonnok ; Wanlaya Uthaisang-Tanechpongtamb ; Benjamas Thanomsub Wongsatayanon Srinakharinwirot University, Bangkok, Thailand

P-145

Synthesis of pH-responsive microspheres by graft polymerization of gelatin Ilaria Altimari ; U. Gianfranco Spizzirri ; Manuela Curcio ; Giuseppe Cirillo ; Ortensia Ilaria Parisi ; Francesco Puoci ; Francesca Iemma ; Nevio Picci University of Calabria, Pharmaceutical Science, Rende, Italy

P-146

Cyclodextrin-polymeric micelle nanocomplex for oncology therapy Alexandra Gil Arranja ; Helena Cabral Marques ; Mafalda Videira Faculty of Pharmacy lisbon University, Pharmaceutical technology, Lisbon, Portugal

P-147

The potential switch from intravenous to oral docetaxel therapy using a trojan nanocapsule delivery system S Attili-Qadri ; T Nassar ; S Benita The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

P-148

Effect of charge carrier lipid on hair growth of liposomes containing finasteride Rengarajan Baskaran ; Sang-Im Lee ; Santhosh-Kumar Nagayya-Sriraman ; Chul-Soon Yong ; Bong-Kyu Yoo Yeungnam University, College of Pharmacy, Kyungsan, Republic of Korea

P-149

Measurement of theophylline ion pair interactions in solution state F Benaouda ; B Forbes ; C P Page ; S A Jones King's College London, Institute of Pharmaceutical Science, London, United Kingdom

P-150

Stealth pH-sensitive liposomes loading 99mtechnetium-HYNIC-β-Ala-Bombesin(7-14) for breast tumor identification Andre Luiz Branco Barros 1; Luciene das Graças1 Mota 1; Carolina de Aguiar Ferreira 1; Marina Melo Antunes Coelho 2; Natássia Caroline Corrêa 3; Geovanni Dantas Cassali 3; Alfredo Miranda Góes 3; Mônica Cristina Oliveira 1; Valbert N Cardoso 1 1Faculdade de Farmacia-UFMG, Belo Horizonte, Brazil; 2Faculdade de Farmacia-UFMG, Analises Clinicas e Toxicológicas, Belo Horizonte, Brazil; 3ICB-UFMG, Belo Horizonte, Brazil

P-151

Characterization of mucoadhesive metronidazole tablets for potential buccal administration J. Balcárková ; F. C. Carvalho ; P. C. Ferrari ; R. C. Evangelista ; M. P. D. Gremião ; A. D. Castro Unesp, Drugs and Medicine, Araraquara, Brazil

P-152

Preparation and characterization of a solid dosage form from the solid dispersion of praziquantel with sodium starch glycolate S. M. Siqueira ; F. S. Campos ; A. L. R. Souza ; A. D. Castro ; M. P. D. Gremião Unesp, Drugs and Medicines, Araraquara, Brazil

P-153

Texture profile analysis of nanostructured systems for cutaneous administration of itraconazole G.M. Luz ; H.R. Silva ; M.H. Hirata ; M. Chorilli ; M.P.D. Gremião School of Pharmaceutical Sciences - UNESP, Drugs and Pharmaceuticals, Araraquara - SP, Brazil

P-154

Structural characterization of liquid-crystalline systems constituted by polyoxyethylene 20 cetyl ether and oleic acid M. Chorilli ; M.H. Oyafuso ; E.E. Funagoshi ; M.P.D. Gremião School of Pharmaceutical Sciences - UNESP, Drugs and Pharmaceuticals, Araraquara - SP, Brazil

P-155

Incorporation of organic cocoa in liquid-crystalline systems stabilizated with polyoxyethlyene 20 cetyl ether E.E. Funagoshi ; M. Chorilli School of Pharmaceutical Sciences - UNESP, Drugs and Pharmaceuticals, Araraquara - SP, Brazil

P-156

Effect of concentration of sodium starch glycolate on the dissolution profile of zidovudine-containing solid dispersions L.N. Pedreiro ; M. Chorilli ; M.P.D. Gremião School of Pharmaceutical Sciences - UNESP, Drugs and Pharmaceuticals, Araraquara - SP, Brazil

P-157

Liposomal dinitroanilines as antileishmanial agents ME Cruz 1; M Carvalheiro 1; R Lopes 1; C Eleuterio 1; G Santos-Gomes 2; E Scoulica 3; A Esteves 4 1University of Lisbon, Faculty of Pharmacy, Lisbon, Portugal; 2Universidade Nova de Lisboa, Inst Higiene Med Tropical, Lisbon, Portugal; 3University of Crete, School of Medicine, Heraklion, Greece; 4LNEG, Unidade Pilhas Combustiveis, Lisbon, Portugal

P-158

Lipid microspheres embedded inside a mucoadhesive buccal film to control the release of lidocaine C. Cavallari ; A. Fini ; l. Rodriguez ; F. Gregorini University of Bologna, Bologna, Italy

P-159

Controlled release behavior of nicotine loaded ion exchange resins for manufacturing chewing gums by direct compression technique Jayachandar Gajendran 1; Julian Schichtel 1; Johannes Kraemer 2; Peter Langguth 3 1Phast GmbH /Johannes Gutenberg University, Institute of Pharmacy and Biochemistry-Therapeutical Life Sciences, Homburg, Germany; 2Phast GmbH, Homburg, Germany; 3Johannes Gutenberg University, Institute of Pharmacy and Biochemistry-Therapeutical Life Sciences, Mainz, Germany

P-160

Preparation and solid-state characterization of nanoporous saquinavir mesylate for aqueous solubility enhancement ML Branham ; T Moyo ; T Govender University of KwaZulu-Natal, Durban, South Africa

P-161

Comparative pharmacokinetic analysis of novel antimalarial artemisinin derivatives after oral administration using Pheroid technology Anne F Grobler 1; J. Dewald Steyn 1; Lubbe Wiesner 2; Richard Haynes 3; Lizette Meeding 1; Liezl Gibhard 1; Awie Kotze 1 1North-West University, Pharmaceutics, Potchefstroom, South Africa; 2University of Cape Town, Clinical pharmacology, Cape Town, South Africa; 3The Hong Kong University of Science and Technology, Department of Chemistry, Kowloon, Hong Kong

P-162

The improvement of water-solubility and toxico-pharmacological properties of drugs by clathration with plant metabolites M.V. Khvostov 1; G.A. Tolstikov 2; T.G. Tolstikova 1 1N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry the Siberian Branch of RAS, Laboratory of Pharmacological Research, Novosibirsk, Russian Federation; 2N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry the Siberian Branch of RAS, Novosibirsk, Russian Federation

P-163

Nanofibers as advanced drug carriers A. Klabanova 1; M. Munzarova 1; M. Juklickova 1; J. Sirc 2; R. Hobzova 2; S. Kubinova 3 1ELMARCO Ltd., Liberec, Czech Republic; 2Academy of Sciences of the Czech Republic, Institute of Macromolecular Chemistry, Prague, Czech Republic; 3Academy of Sciences of the Czech Republic, Institute of Experimental Medicine, Prague, Czech Republic

P-164

Nanostructured porous silicon microparticles for improved Peptide YY delivery Miia Kovalainen 1; Juha Mönkäre 1; Ermei Mäkilä 2; Jarno Salonen 2; Vesa-Pekka Lehto 1; Karl-Heinz Herzig 3; Kristiina Järvinen 1 1University of Eastern Finland, Kuopio, Finland; 2University of Turku, Turku, Finland; 3University of Oulu, Oulu, Finland

P-165

Structure–activity relationships of methylated N-aryl chitosan derivatives for enhancing paracellular permeability across Caco-2 cells Jariya Kowapradit 1; Praneet Opanasopit 1; Tanasait Ngawhirunpat 1; Theerasak Rojanarata 1; Auayporn Apirukaramwong 1; Warayuth Sajomsang 2 1Silpakorn University, Faculty of Pharmacy, Nakorn Pathom, Thailand; 2National Nanotechnology Center, Thailand Science Park, Pathumthani, Thailand

P-166

Antipsychotic-loaded solid lipid nanoparticles (SLN) for oral delivery: modeling release profile Ana Silva 1; Carla Martins Lopes 2; Delfim Santos 3; Eliana Souto 2; Domingos Ferreira 3 1Faculty of Pharmacy, Porto University; Faculty of Health Sciences, Fernando Pessoa University, Laboratory of Pharmaceutical Technology, Porto, Portugal; 2Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal; 3Faculty of Pharmacy, Porto University, Laboratory of Pharmaceutical Technology, Porto, Portugal

P-167

Transdermal iontophoresis of ondansetron hydrochloride in vitro: Modulation of convective solvent flow and its effect on transport efficiency

Deniz Ozdin ; Sevgi Gungor Istanbul University Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Turkey

P-168

Streamlining innovative technologies through an open innovation model: effective nasal delivery of a powerful pain killer drug Lorenzo Pradella Zcube srl, General Management, Bresso (Milan), Italy

P-169

Nano-structured silicon particles as a solid dosage form for poorly soluble drugs F Wang ; T Barnes ; C.A. Prestidge University of South Australia, Ian Wark Research Institute, Mawson Lakes, Australia

P-170

Synthesis, characterization and in vivo delivery of siRNA-Squalene nanoparticles targeting RET/PTC1 fusion oncogene in papillary thyroid carcinoma Mouna Raouane 1; Didier Desmaele 2; Claire Gueutin 2; Fatima Zouhiri 2; Ridha Ben Salah 3; Marie Gilbert-Sirieix 4; Liliane Massaad-Massade 4; Patrick Couvreur 2 1Université Paris sud 11, Faculté de pharmacie, UMR /CNRS 8612, Ile-de-France, France; 2Université Paris sud11, Faculté de pharmacie, UMR CNRS 8612, Chatenay-Malabry, France; 3Faculté de Médecine Ibn El Jazzar de Sousse, Université de Sousse, Unité de Recherche de Biophysique, 00/UR/08-02, Sousse, Tunisia; 4Institut Gustave Roussy, UMR CNRS 8203, Villejuif, France

P-171

A novel trojan nanoparticle drug-delivery system for enhancing intestinal transport of lopinavir without co-administration of ritonavir Ayala Rohald ; Taher Nassar ; Simon Benita The Institute for Drug Research of the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

P-172

In vitro propranolol permeation and skin retention from transdermal film Antonio Romano ; Cristina Padula ; Sara Nicoli ; Patrizia Santi University of Parma, Pharmacy, Parma, Italy

P-173

Solid lipid microparticles for the buccal administration of melatonin Angelica Marano ; Cristina Padula ; Sara Nicoli ; Patrizia Santi University of Parma, Pharmacy, Parma, Italy

P-174

Development of polymeric nanocapsules of Poly (2-Ethylhexyl Acrylate) by in situ polymerization P. L. Goto ; S. P. Carneiro ; S. McCloskey ; O. D. H. Santos Universidade Federal de Ouro Preto, Departamento de Farmácia, Ouro Preto, Brazil

P-175

Optimization of Ibuprofen microemulsion and influence of formulation strategy on Ibuprofen permeation through rat skin Behzad Sharif Makhmal Zadeh ; Shiva Torabi ; Armita Azar Panah Ahvaz Jundishapur University of Medical Sciences, Pharmaceutics, Ahvaz, Islamic Republic of Iran

P-176

Effect of Kollidon® superdisintegrants on the release of mefenamic acid from microsponge tablets Aysu Yurdasiper ; Ferhan Sevgi Ege University, Faculty of Pharmacy, Pharmaceutical Technology, Izmir, Turkey

P-185

Evaluation of antioxidant activity of milk thistle extract complexed with hydroxypropyl-β-cyclodextrin G Spada ; M Cossu ; G Rassu ; E Gavini ; P Giunchedi University of Sassari, department of Drug Sciences, Sassari, Italy

P-177

Optimising the formulation of silica-lipid hybrid drug delivery systems C Lim 1; K. Bremmell 2; A Tan 1; C Prestidge 1 1University of South Australia, Ian Wark Research Institute, Mawson Lakes, Australia; 2University of South Australia, Sansom Research Institute, Adelaide, Australia

P-178

Characterization of silver sulfadiazine-loaded solid lipid nanoparticles by thermal analysis L Catenacci 1; M. Sorrenti 1; G. Bruni 2; G. Sandri 1; C. Caramella 1; G.P. Bettinetti 1 1University of Pavia, Department of drug sciences, Pavia, Italy; 2University of Pavia, Department of Chemistry, Pavia, Italy

P-179

Injectable hydrogels for localized release of proteins Maria Jose Diz-Lojo ; Ana Rey-Rico ; Carmen Alvarez-Lorenzo ; Angel Concheiro Universidad de Santiago de Compostela, Santiago de Compostela, Spain

P-180

Sponge-like dressings loaded with silver sulfadiazine: wound healing and antimicrobial properties G. Sandri ; M.C. Bonferoni ; S. Rossi ; F. Ferrari ; F. D'Autilia ; E. Dellera ; P. Grisoli ; C. Caramella University of Pavia, Department of drug sciences, Pavia, Italy

P-181

Poliaggregates of amphotericin B: an in vitro toxicity study MA Silva-Filho 1; SDVS Siqueira 1; PRT Medeiros 2; IB Araujo 1; EST Egito 1; Nereide Magalhaes 3 1Federal University of Rio Grande do Norte, Department of Pharmacy, Natal, Brazil; 2Federal University of Rio Grande do Norte, Computer Science Engineering, Natal, Brazil; 3Federal University of Pernambuco, Recife, Pernambuco, Brazil

P-182

In vitro and in vivo evaluation of an injection-molded capsular device for oral pulsatile release A Gazzaniga ; M Cerea ; A Cozzi ; MD Del Curto ; A Foppoli ; A Maroni Università degli Studi di Milano, Dipartimento di Scienze Farmaceutiche “P. Pratesi”, Milano, Italy

P-184

Silica-lipid hybrid materials enhance the oral absorption of poorly soluble drugs A Tan 1; S Simovic 1; A Davey 1; B Boyd 2; C.A. Prestidge 1 1University of South Australia, Ian Wark Research Institute, Mawson Lakes, Australia; 2Monash University, MIPS, Melbourne, Australia

P-187

In vitro and in vivo antioxidant activities of the leaves of Chrysophyllum albidum G A. H. Adebayo ; A. O. Abolaji ; B. T. Olorunfemi Covenant University, Biochemistry and Molecular Biology Unit, Department of Biological Sciences, PMB 1023, Canaanland, Ota, Nigeria

P-188

Evaluation of antioxidant and leishmanicidal activities from inflorescences of Angeratum fastigiatum (Asteraceae) Nathalia Lucca Silva 1; Ivanildes Vasconcelos Rodrigues 1; Juliana Neves de Paula Souza 1; Levi Eduardo Soares Reis 2; Samuel Leôncio Braga 2; Alexandre Barbosa Reis 2; Orlando David Henrique dos Santos 2; Gustavo Henrique Bianco de Souza 2 1School of Pharmacy-UFOP, Ouro Preto, Brazil; 2Schooll of Pharmacy-UFOP, Pharmaceutical Sciences, Ouro Preto-MG, Brazil

P-189

X-ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine in complex with double helix DNA d(CGTACG) Marta Ferraroni ; Carla Bazzicalupi ; Anna Rita Bilia ; Paola Gratteri University of Florence, Florence, Italy

P-190

Antihyperalgesic activity of verbascoside in two models of neuropathic pain Benedetta Isacchi ; Romina Iacopi ; Maria Camilla Bergonzi ; Carla Ghelardini ; Nicoletta Galeotti ; Monica Norcini ; Elisa Vivoli ; Franco Francesco Vincieri ; Anna Rita Bilia University of Florence, Florence, Italy

P-191

Anti-aging constituents of Dimocarpus longan Lour Hsiu-Chen Chan 1; George Hsiao 2; Ching-Kuo Lee 3 1Taipei Medical University, Graduate Institute of Pharmacognosy Sciences, Taipei City, Taiwan; 2Taipei Medical University, Graduate Institute of Medical Sciences, Taipei City, Taiwan; 3Taipei Medical University, School of Pharmacy, Taipei City, Taiwan

P-192

Chemical constituents and melanogenesis-inhibitory effects of Ligusticum sinense Y.-T. Chu 1; C.-K. Lee 2 1Taipei Medical University, Graduate Institute of Pharmacogonosy, Taipei City, Taiwan; 2Taipei Medical University, School of Pharmacy, Taipei City, Taiwan

P-193

Pharmacological properties of Byrsonima intermedia A. Juss (Malpighiaceae) in peptic ulcer R de C dos Santos 1; M Sannomyia 2; C M Rodrigues 3; W Vilegas 3; L R M da Rocha 1; C A Hiruma-Lima 1 1Biosciences Institute of Botucatu, Physiology, Botucatu, Brazil; 2School of Arts, Sciences and Humanities, São Paulo, Brazil; 3Chemistry Institute, Organic Chemistry, Araraquara, Brazil

P-194

Comparative studies on Plantago species on the basis of antioxidant and cytotoxic activities U. Þebnem Harput 1; Yasin Genç 1; Akito Nagatsu 2; Ýclal Saraçoðlu 3 1Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey; 2Kinjo Gakuin University, College of Pharmacy, Nagoya, Japan; 3Hacettepe University Faculty of Pharmacy, Department of Pharmacognosy, Ankar, Turkey

P-195

In vitro anticancer activity and structure-activity relationships of flavonoid glycosides Ýclal Saraçoðlu ; U. Þebnem Harput Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey

P-196

Investigation of flavonoid metabolites after ingestion of Carpobrotus rossii extract in the rat Qi Ying Lean 1; Christian Narkowicz 2; Dominic Geraghty 3; Adam Pirie 2; Glenn Jacobson 2 1University of Technology Mara, Faculty of Pharmacy, Pulau Pinang, Malaysia; 2University of Tasmania, School of Pharmacy, Hobart, Australia; 3University of Tasmania, School of Human Life Sciences, Launceston, Australia

P-197

Variations in Hyoscyamine and scopolamine production of black henbane (Hyoscyamus niger) plant parts with nitrogen application and water deficit stress Farhad Mohabbati 1; Mansour Ghorbanpour 2; Naser Majnoon Hossieni 3; Shamsali Rezazadeh 4; Mansour Omidi 3; Kazem Khavazi 5; Alireza Etminan 6; Lia Shooshtari 6 1Karaj Branch, Islamic Azad University, Department of Agronomy, Karaj, Islamic Republic of Iran; 2Arak university, Faculty of Agriculture and Natural resources, Medicinal plants, Arak, Islamic Republic of Iran; 3Tehran University, Agronomy and Plant breeding, Karaj, Islamic Republic of Iran; 4Institute of Medicinal Plants (IMP), Pharmacognosy, Karaj, Islamic Republic of Iran; 5Soil and Water Institute, Microbiology, Karaj, Islamic Republic of Iran; 6Islamic Azad University, Kermanshah Branch, Plant Breeding, Kermanshah, Islamic Republic of Iran

P-198

The growth inhibitory effect of Nigella sativa essential oil, thymoquinone and thymohydroquinone in combination with selected antibiotics against Staphylococcus aureus in vitro J Rondevaldova ; P Novy ; L Kokoska Czech University of Life Sciences Prague, Institute of Tropics and Subtropics, Department of Crop Sciences and Agroforestry, Prague, Czech Republic

P-199

Chemical composition of the essential oil from Microlicia graveolens (Melastomaceae) and antimicrobial activity A. B. Toudahl 1; A. K. Jäger 1; L. D. Morais 2; G. H. B. Souza 2; S. A. Vieira-Filho 2; T. P. Figueiredo 2; O. D. H. Santos 2 1University of Copenhagen, Department of Medicinal Chemistry, Copenhagen, Danmark; 2Universidade Federal de Ouro Preto, Departamento de Farmácia, Ouro Preto, Brazil

P-200

Sexual hormone-like effect of raw drone milk in female rats Adrienn Seres ; Eszter Ducza ; Róbert Gáspár University of Szeged, Department of Pharmacodynamics and Biopharmacy, Szeged, Hungary

P-201

Antioxidant property and determination of total phenolic compounds in collected species of Parque Estadual do Itacolomi, Ouro Preto-MG Gustavo Souza 1; Juliana Souza 1; Ivanildes Rodrigues 1; Orlando Santos 1; Hildeberto Sousa 2 1School of Pharmacy - UFOP, Pharmaceutical Sciences, Ouro Preto-MG, Brazil; 2ICEB - UFOP, Department of Biodiversity, Evolution and Environment, Ouro Preto-MG, Brazil

P-202

The effects of Feijoa sellowiana Berg. fruits on the antioxidant defense system, lipid peroxidation and tissue morphology in rats II Tatli 1; I Kucukkurt 2; S Ince 3; H Keles 4; E Kupeli Akkol 5; C Kahraman 6; HH Demirel 4

1Hacettepe University, Faculty of Pharmacy, Pharmaceutical Botany, Ankara, Turkey; 2Afyon Kocatepe University, Faculty of Veterinary Medicine, Biochemistry, Afyon, Turkey; 3Afyon Kocatepe University, Faculty of Veterinary Medicine, Pharmacology and Toxicology, Afyon, Turkey; 4Afyon Kocatepe University, Faculty of Veterinary Medicine, Pathology, Afyon, Turkey; 5Gazi University, Faculty of Pharmacy, Pharmacognosy, Ankara, Turkey; 6Hacettepe University, Faculty of Pharmacy, Pharmacognosy, Ankara, Turkey

P-203

Effects of different cytokinins on micropropagation of salvia officinalis Karolina Wielgus 1; Aleksandra Luwanska 1; Daniel Lipinski 2; Joanna Zeyland 2; Marlena Szalata 2; Ryszard Slomski 2 1Institute of Natural Fibres & Medicinal Plants, Department of Biotechnology, Poznan, Poland; 2Poznan University of Life Sciences, Department of Biochemistry and Biotechnology, Poznan, Poland

P-204

Development of colon-specific melatonin-sodium alginate gel formulations: I. In vitro evaluations F. Esiringu 1; F. Acarturk 2; F. Tugcu-Demiroz 2 1Pharmaceutical Research and Development Center Inc., Duzce, Turkey; 2Gazi University Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey

P-205

Development and release mechanism of diltiazem hydrochloride sustained release matrix tablet Dheeraj Baviskar 1; Rajesh Sharma 2; Dinesh Jain 3 1KVPS, Institute of Pharmaceutical Education, Pharmaceutics, Boradi, India; 2School of Pharmacy, D.A.V.V., Phashila Campus, Pharmaceutical Chemistry, Indore, India; 3College of Pharmacy, I.P.S. Academy, Pharmaceutics, Indore, India

P-206

Development and evaluation of orally disintegrating tablet formulation of rizatriptan benzoate E Tuncay ; N Celebi Gazi University Faculty of Pharmacy, Pharmaceutical Technology, Ankara, Turkey

P-207

Predictive models for anti-retroviral drug maximum recommended therapeutic dose (MRTD) M Branham ; T Govender University of KwaZulu-Natal, Durban, South Africa

P-208

sNLC – a new treatment strategy against AD Cornelia Keck ; Rainer Müller Freie Universität Berlin, Berlin, Germany

P-209

The effect of formulation variables on the release patterns and structural characteristics of desonide topical emulsions J Marto 1; C Salgado 1; E Oliveira 2; H Ribeiro 1 1Faculty of Pharmacy, University of Lisbon, Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Lisbon, Portugal; 2AtralCipan Group, Lisbon, Portugal

P-210

Semisolid emulsion systems: Rheological and thermal characterization S Raposo 1; A Salgado 1; G Eccleston 2; M Urbano 3; H Ribeiro 1

1Faculty of Pharmacy, University of Lisbon, Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Lisbon, Portugal; 2University of Strathclyde, Pharmaceutical Sciences, Glasgow, United Kingdom; 3Laboratório Edol, Lisbon, Portugal

P-211

Semisolid Emulsion systems: Prediction of physical stability S Raposo 1; A Salgado 1; G Eccleston 2; M Urbano 3; H Ribeiro 1 1Faculty of Pharmacy, University of Lisbon, Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Lisbon, Portugal; 2University of Strathclyde, Pharmaceutical Sciences, Glasgow, United Kingdom; 3Laboratório Edol, Lisbon, Portugal

P-212

Formulation of w/o/w multiple emulsions containing niacinamide: an effect of the components on the characteristics Figen Tirnaksiz 1; Yeliz Fidan 2 1Gazi University, Faculty of Pharmacy, Pharmaceutical Technology, Ankara, Turkey; 2Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey

P-213

Preparation and evaluation of propranolol HCL microcapsules containing Eudragit polymers using emulsion solvent evaporation method Hadi Afrasiabi Garekani 1; Meisam Rakhshan 2; Fatemeh Sadeghi 2 1Pharmaceutical research center and School of Pharmacy, Pharmaceutics, Mashhad, Islamic Republic of Iran; 2School of Pharmacy, Pharmaceutics, Mashhad, Islamic Republic of Iran

P-214

The influence of incorporated drug on moving front position within swollen xanthan studied by magnetic resonance imaging Saša Baumgartner 1; Urška Mikac 2; Ana Sepe 2; Julijana Kristl 3 1University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia; 2Jožef Stefan Institute, Ljubljana, Slovenia; 3University of Ljubljana, Ljubljana, Slovenia

P-215

Characterization of gentamicin-bentonite complex A Bellini ; D Malferrari ; V Iannuccelli ; G Coppi University of Modena and Reggio Emilia, Modena, Italy

P-216

Rheological, mechanical and bioadhesive characterization of carboxypolymethylene hydrogel for topical application G.M.F. Calixto ; F.C. Carvalho ; I. Katakeyama ; G.M. Luz ; M.P.D. Gremião ; M. Chorilli School of Pharmaceutical Sciences - UNESP, Drugs and Pharmaceuticals, Araraquara - SP, Brazil

P-217

Preparation of blends of dextran of different molecular weights F.S. Campos ; L.Z. Ferrari ; M. Chorilli ; M.P.D. Gremião School of Pharmaceutical Sciences - UNESP, Drugs and Pharmaceuticals, Araraquara - SP, Brazil

P-218

The Influence of Hydrophilic Pore Formers on Metoprolol Succinate Release from Mini-tabs Coated with Aqueous Ethylcellulose Dispersion Kevin Hughes 1; Vuong Hue 2; Levina Marina 2; Farrell Thomas 3; Rajabi-Siahboomi Ali 3 1Colorcon Ltd, Formulation Technologies, Dartford, United Kingdom; 2Colorcon Ltd, Product Development, Dartford, United Kingdom; 3Colorcon Inc, Product Development, Harleysville, United States

P-219

Polymer delivery of Hydroxycamptothecin against C6 glioma Songqing Liu ; Jing Hu ; Huafei Tang Southwest Hospital, Third Military Medical University, Department of Pharmacy, Chongqing, China

P-220

Influence of hydrophilic surfactants on the properties of multiple W/O/W emulsions containing betamethasone I. Ozcan ; T. Senyigit ; E. Korkmaz ; M. Ozyazici ; O. Ozer Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Izmir, Turkey

P-221

Hemostatic tablets to control bleeding in post-extractive alveolar wounds Antonella Nappi 1; Francesca Ungaro 1; Fabiana Quaglia 1; Gianrico Spagnuolo 2; Gaetano Marenzi 2; Gilberto Sammartino 2; Agnese Miro 1 1University of Napoli Federico II, Dept. of Pharmaceutical and Toxicological Chemistry, Napoli, Italy; 2University of Napoli Federico II, Dept of Odontostomatological and Maxillofacial Sciences, Napoli, Italy

P-222

Production of coextrudates based on hydroxypropylmethylcellulose Andreia Raimundo 1; Martin Wahl 2; João Pinto 1 1iMed.UL - Faculdade de Farmácia, Universidade de Lisboa, Tecnologia Farmacêutica, Lisboa, Portugal; 2Eberhard Karls Universitaet Tuebingen, Pharmazeutisches Institut, Tuebingen, Germany

P-223

A new assembled delivery system for helicobacter pylori therapy C Conti 1; A Rossi 1; P Barata 2; S Delfim 3; P Colombo 1 1University of Parma, Department of Pharmacy, Parma, Italy; 2University of Fernando Pessoa, Faculty of Health Sciences, Porto, Portugal; 3University of Porto, Faculty of Pharmacy, Porto, Portugal

P-224

The effect of HPMC type and concentration on the physicomechanical and release properties of ibuprofen and Eudragit RS pellets prepared by extrusion-spheronization Fatemeh Sadeghi ; Mohammad Amirpour Rayeni ; Hadi Afrasiabi Garekani School of Pharmacy, Pharmaceutics, Mashhad, Islamic Republic of Iran

P-225

Gemcitabine-loaded PEGylated unilamellar liposomes in the treatment of papillary thyroid carcinomas M Vono 1; D Cosco 1; C Celia 1; D Paolino 2; M Celano 1; D Russo 1; M Fresta 1 1University "Magna Graecia", Department of Pharmacobiological Sciences, Catanzaro, Italy; 2University "Magna Graecia", Department of Experimental and Clinical Medicine, Catanzaro, Italy

P-226

Liposomal multidrug carriers encapsulating gemcitabine and tamoxifen for the treatment of breast cancer D Cosco 1; C Federico 1; F Casale 1; D Paolino 2; M Fresta 1 1University "Magna Graecia", Department of Pharmacobiological Sciences, Catanzaro, Italy; 2University "Magna Graecia", Department of Experimental and Clinical Medicine, Catanzaro, Italy

P-227

Linoleic acid-loaded ethosomes® and transfersomes® as topical drug carriers for hyperpigmentation disorders treatment E Trapasso 1; F Cilurzo 1; D Cosco 2; P Gallelli 2; C Celia 2; D Paolino 1 1University "Magna Graecia", Department of Experimental and Clinical Medicine, Catanzaro, Italy; 2University "Magna Graecia", Department of Pharmacobiological Sciences, Catanzaro, Italy

P-228

Topical treatment of squamous cell carcinoma by using paclitaxel-loaded ethosomes® F Cilurzo 1; E Trapasso 1; D Cosco 2; C Celia 2; D Paolino 1; M Fresta 2 1University "Magna Graecia", Department of Experimental and Clinical Medicine, Catanzaro, Italy; 2University "Magna Graecia", Department of Pharmacobiological Sciences, Catanzaro, Italy

P-229

Physico-chemical characterization and cytotoxicity assays for poloxamer-based tramadol formulations ACM dos Santos 1; PS Melo 2; F Yokaichiya 3; EC de Lima 1; DR de Araujo 1 1Universidade Federal do ABC, Centro de Ciencias Naturais e Humanas, Santo André-SP, Brazil; 2Faculdades Integradas Metropolitanas de Campinas, Campinas-SP, Brazil; 3Laboratorio Nacional de Luz Sancrotron, Campinas-SP, Brazil

P-230

Influence of terpenes on membrane fluidity in empty and temoporfin-loaded invasomes N. Dragicevic-Curic 1; D. Pecarski 2; K Milosevic-Kostadinovic 3; M. Friedrich 4; W. Plass 4; V. Albrecht 5; A. Fahr 6 1Apoteka "Beograd", Belgrade, Serbia; 2Mella Cosmetics d.o.o., Belgrade, Serbia; 3Apoteka Medicor, Kotor, Montenegro; 4Department of Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Jena, Germany; 5Biolitec AG, Jena, Germany; 6Department of Pharmaceutical Technology, Friedrich Schiller University Jena, Jena, Germany

P-231

Liposomes modified loading 99mtechnetium-DTPA to identify inflammatory focus in an experimental model in rats Luciene das Graças Mota ; Simone Odilia A Fernandes ; André Luis Branco Barros ; Talita Guieiro R Rocha ; Shirleide Santos Nunes ; Mônica Cristina Oliveira ; Valbert N Cardoso Faculdade de Farmácia, Belo Horizonte, Brazil

P-232

Improved antimycobacterial effect of paromomycin through association to liposomes M.M. Gaspar ; J. Pereira ; A. Constantino ; C.V. Eleutério ; M.E.M. Cruz Faculty of Pharmacy University of Lisbon, Farmácia Galénia e Tecnologia Farmacêutica, Lisbon, Portugal

P-233

Oryzalin liposomes for Leishmania treatment R Lopes ; M Carvalheiro ; C Eleutério ; M.L. Corvo ; A.J. Almeida ; M.E.M. Cruz Faculty of Pharmacy, University of Lisbon, Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Lisbon, Portugal

P-234

9-cis-Retinoic Acid-loaded PEG-coated PLGA-nanoparticles: characterization and in vitro evaluation of pharmacological activity R Molinaro 1; D Cosco 1; E Gentile 1; D Scalise 1; D Paolino 2; M Fresta 1 1University "Magna Graecia", Department of Pharmacobiological Sciences, Catanzaro, Italy; 2University "Magna Graecia", Department of Experimental and Clinical Medicine, Catanzaro, Italy

P-235

Development of squalane and retinoic acid nanoemulsion for topical application using phase inversion H. Mezadri ; S. A. Vieira-Filho ; O. D. H. Santos Universidade Federal de Ouro Preto, Departamento de Farmácia, Ouro Preto, Brazil

P-236

Targeted delivery of methotrexate to tumor cells using biotin functionalized methotrexate-human serum albumin conjugated nanoparticles Azade Taheri 1; Rassoul Dinarvand 1; Fatemeh Atyabi 1; Farank Salman Nouri 1; Atefe Taheri 2; Pooria Mansoori 3 1Faculty of Pharmacy, Tehran University of Medical Sciences, Department of Pharmaceutics, Tehran, Islamic Republic of Iran; 2Faculty of Dentistry, Tehran University of Medical Sciences, Department of Pathology, Tehran, Islamic Republic of Iran; 3Faculty of Medicine, Jondishapour University of Medical Sciences, Department of Radiology, Ahwaz, Islamic Republic of Iran

P-237

Preparation and characterization of trastuzumab - polyethylene glycol decorated carbon nanotubes for targeted delivery of chemotherapeutic agents AM Tamaddon ; FS Farvadi ; SS Abolmaali Shiraz University of Medical Sciences, Pharmaceutics, Shiraz, Islamic Republic of Iran

P-238

Lipid nanoparticles as drug delivery systems C Vitorino 1; J J Sousa 1; A A C C Pais 2; A J Almeida 3 1University of Coimbra, Faculty of Pharmacy, Coimbra, Portugal; 2University of Coimbra, Chemistry Department, Coimbra, Portugal; 3University of Lisbon, Faculty of Pharmacy, Lisbon, Portugal

P-239

Formulation and evaluation of different nanoparticulate polyelectrolyte complexes Pegi Ahlin Grabnar ; Julijana Kristl University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia

P-240

Nanoparticulate system of chitosan-sodium deoxycholate as gene delivery A Cadete 1; L Figueiredo 1; CCR Calado 2; AJ Almeida 1; LMD Gonçalves 1 1FFUL, iMed, Lisboa, Portugal; 2Universidade Católica Portuguesa, Faculdade de Engenharia, Rio de Mouro, Portugal

P-241

Nanoparticles against Alzheimer’s disease: PEG-PACA nanoparticles are able to link the AB-peptide and influences its aggregation kinetic D. Brambilla 1; R. Verpillot 1; M. Taverna 1; B. Le Droumaguet 1; J. Nicolas 1; J. Kona 2; L. De Kimpe 3; M. Canovi 4; M. Gobbi 4; V. Nicolas 5; M. Salmona 4; W. Schepe 3; I. Tvaroška 2; P. Couvreur 1; K. Andrieux 1 1University Paris Sud 11, Chatenay-Malabry, France; 2Slovak Academy of Sciences, Bratislava, Slovakia; 3Academic Medical Center, Amsterdam, Netherlands; 4Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy; 5University Paris Sud 11, 92296 Chatenay-Malabry, France

P-242

Effects of polymeric nanocarrier structures on internalization in cell monolayer and excised skin A. Badihi ; N. Debotton ; S. Benita The Institute for Drug Research of the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

P-243

Cytotoxicity evaluation of Locust Bean Gum new derivatives and their application in drug delivery L Braz 1; A Grenha 2; D Ferreira 3; AM Rosa da Costa 1; B Sarmento 3 1University of Algarve, CIQA – Centre for Research in Chemistry of Algarve, Faro, Portugal; 2University of Algarve, CBME - Centre for Molecular and Structural Biomedicine, Faro, Portugal; 3University of Porto, Department of Pharmaceutical Technology, Faculty of Pharmacy, Porto, Portugal

P-244

Biodegradable radiotherapeutic microspheres of polyester/Holmium-166 for liver cancer therapy Mariangela Burgos M. de Azevedo 1; Nanci Nascimento 2; Geovanna Pires 2; Jaime R. Souza 2 1IPEN Instituto de Pesquisas Energéticas e Nucleares, Biotechnology Center, Sâo Paulo, Brazil; 2Instituto de Pesquisas Energéticas e Nucleares -IPEN, Biotechnology Center, Brazil

P-245

Sponge-like medications containing chitosan ascorbate nanoparticles for vaginal application Puccio Antonella ; Rossi Silvia ; Ferrari Franca ; Bonferoni Maria Cristina ; Sandri Giuseppina ; Grisoli Pietro ; Dacarro Cesare ; Caramella Carla University of Paiva, Department of Drug Sciences, Pavia, Italy

P-246

Nanoparticle microarrays for the detection of cellular uptake and distribution in retinal pigment epithelial cells Marco G. Casteleijn ; Arto Urtti University of Helsinki, Center for Drug Research, Helsinki, Finland

P-247

Development of nanoparticles ionically crosslinked chitosan/tripolyphosphate for nasal administration of protein: particle size and zeta potential C.P. Kill ; M. Chorilli ; M.P.D. Gremião School of Pharmaceutical Sciences - UNESP, Drugs and Pharmaceuticals, Araraquara - SP, Brazil

P-248

Modified pullulan-based nanoparticles for protein delivery Marita Dionísio 1; Ana M. Rosa da Costa 2; Sandra S. Soares 2; Ana Grenha 2 1Faculty of Sciences and Technology - University of Algarve, Institute for Biotechnology and Bioengineering/Centre for Molecular and Structural Biomedicine, Faro, Portugal; 2Faculty of Sciences and Technology - University of Algarve, Faro, Portugal

P-249

Resveratrol loaded solid lipid nanoparticles for dermal application: Protection against reactive oxygen species E.H. Gokce 1; E. Korkmaz 1; G. Sandri 2; M.C. Bonferoni 2; O. Ozer 1 1Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technolgy, Ýzmir, Turkey; 2University of Pavia, School of Pharmacy, Department of Pharmaceutical Chemistry, Pavia, Italy

P-250

Preparation and evaluation of nanoparticles loaded with clozapine for controlled release Jahnavi Gopisetti ; Avula Prameela Rani Acharya Nagarjuna University, Pharmaceutics, Vijayawada, India

P-251

The application of genipin as cross-linker of chitosan/carrageenan nanoparticles C Teixeira 1; AM Rosa da Costa 2; A Grenha 1

1University of Algarve, CBME - Centre for Molecular and Structural Biomedicine/IBB - Institute for Biotechnology and Bioengineering, Faro, Portugal; 2University of Algarve, CIQA - Centre for Research in Chemistry of Algarve, Faro, Portugal

P-252

Dry powder DNA nanoparticles prepared by an aerosol flow reactor method M Hanzlikova 1; J Raula 2; E Kauppinen 2; A Urtti 3; M Yliperttula 1 1University of Helsinki, Division of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, Helsinki, Finland; 2Aalto University, School of Science, NanoMaterials Group, Department of Applied Physics, Espoo, Finland; 3University of Helsinki, Centre for Drug Research, Helsinki, Finland

P-254

Development of polyhydroxy surfactant based lipid nanoparticles A Kovacevic 1; S Savic 1; G Vuleta 1; R.H. Müller 2; C.M. Keck 2 1Faculty of Pharmacy, University of Belgrade, Department of Pharmaceutical Technology and Cosmetology, Belgrade, Serbia; 2Freie Universität Berlin, Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Berlin, Germany

P-255

Fluorescent probe, designed for particular nanocarriers, provides superior intracellular visualization J Kristl ; K Teskaè Plajntek ; S Pajk ; B Govedarica ; S Peèar ; S Srèiè Faculty of Pharmacy; University of Ljubljana, Ljubljana, Slovenia

P-256

PEGylated poly(alkyl cyanoacrylate) nanoparticles functionalized by click chemistry for applications in Alzheimer's disease D Brambilla 1; C Zona 2; B Le Droumaguet 1; J Nicolas 1; F Nicotra 3; M Canovi 4; M Gobbi 4; K Andrieux 1; P Couvreur 1 1Université Paris Sud XI, UMR CNRS 8612, Chatenay Malabry, France; 2University of Milano-Bicocca, Department of Biotechnology and Bioscience, Milano, Italy; 3University of Milano-Bicocca, UMR CNRS 8612, Milano, Italy; 4Istituto di Ricerche Farmacologiche “Mario Negri”, Department of Biochemistry and Molecular Pharmacology, Milano, Italy

P-257

Nanoassemblies of nucleoside analogues coupled to terpenoids: Structural analysis Elise Lepeltier ; Claudie Bourgaux ; Joachim Caron ; Eric Sliwinski ; Didier Desmaële ; Patrick Couvreur University of Paris Sud, UMR CNRS 8612, Châtenay Malabry, France

P-258

Biodistribution study of rifampin bound to surfactant-coated polymeric nanoparticles Olga Maksimenko 1; Andrey Bud’ko 1; Lyudmila Vanchugova 1; Elena Shipulo 1; Jörg Kreuter 2; Svetlana Gelperina 1 1Nanosystem Ltd., R&D, Moscow, Russian Federation; 2Goethe University, Institute of Pharmaceutical Technology, Frankfurt-am-Main, Germany

P-259

Formulation and Stability Studies on NSAIDs-containing SLN G Mancini 1; LMD Gonçalves 1; R Lopes 1; A Bica 2; HM Ribeiro 1; AJ Almeida 1 1Faculty of Pharmacy, University of Lisbon, Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Lisbon, Portugal; 2Laboratório de Estudos Farmacêuticos, Lisbon, Portugal

P-260

Preparation, characterization and stability of Glycyrrhetinic acid smartCrystal® M Mishra 1; R Shegokar 1; RH Müller 1; S Gohla 2 1Freie Universität Berlin, Institute of Pharmacy, Dept. of Pharmaceutics, Biopharmaceutics & NutriCosmetics, Berlin, Germany; 2Research & Development of the La Prairie Group - Juvena, Volketswil, Switzerland

P-261

Iron oxide PLGA nanoparticles as magnetic responsive drug delivery systems I Peça ; A Roque ; A Bicho ; M Cardoso Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Chemistry Department, Caparica, Portugal

P-262

Magnetoliposomes: preparation and characterization S. Petralito 1; R. Spera 1; G. D'Inzeo 2; M. Liberti 2; F. Apollonio 2 1Sapienza University of Rome, Department of Chemistry and Technology of Drug, Rome, Italy; 2Sapienza University of Rome, Department of Information Engineering, Electronics and Telecommunications, Rome, Italy

P-263

Development and characterization of thiomer-protamine nanoparticles for scale-up experiments C. Petschacher 1; J. Barthelmes 2; A. Bernkop-Schnürch 2; J. Wagner 3; A. Zimmer 1 1Karl-Franzens-Unsiversity Graz, Institute of Pharmaceutical Sciences/Department of Pharmaceutical Technology, Graz, Austria; 2Leopold-Franzens-University Innsbruck, Institute of Pharmacy/Department of Pharmaceutical Technology, Innsbruck, Austria; 3University of Technology Graz, Institute for Electron Microscopy, Graz, Austria

P-264

Sustained delivery nanoassemblies for combined photodynamic and conventional therapy of cancer C Conte 1; F Ungaro 1; G Maglio 2; R Palumbo 2; M.T. Sciortino 3; A Mazzaglia 4; F Quaglia 1 1University of Napoli Federico II, Dept. of Pharmaceutical and Toxicological Chemistry, Napoli, Italy; 2University of Napoli Federico II, Dept. of Chemistry "Paolo Corradini", Napoli, Italy; 3University of Messina, Dept. of Life Sciences, Messina, Italy; 4National Research Council of Italy (CNR), Institute of Nanostructured Materials, Messina, Italy

P-265

Characterization of cross-linked chitosan/carrageenan nanoparticles S. Rodrigues ; S. S. Soares ; A. Grenha FCT, UAlg, IBB/CBME, LA, Faro, Portugal

P-266

Encapsulation of quercetin and resveratrol in liposomes: A fractional factorial design study P.G. Cadena 1; M.A. Pereira 1; R.B.S. Cordeiro 1; I.M.F. Cavalcanti 1; B. Barros Neto 2; M.C.B. Pimentel 1; J.L. Lima Filho 1; V.L. Silva 3; N.S. Santos-Magalhães 1 1Federal University of Pernambuco, Laboratório de Imunopatologia Keizo Asami, Recife, Brazil; 2Federal University of Pernambuco, Departamento de Química Fundamental, Recife, Brazil; 3Federal University of Pernambuco, Laboratório de Engenharia da Qualidade e Ambiental, Recife, Brazil

P-267

Niosomal Paclitaxel: Development, characterization and in vivo comparision with marketed formulation Zerrin Sezgin Bayindir 1; Arzu Onay Besikci 2; Nilufer Yuksel 1

1Ankara University School of Pharmacy, Pharmaceutical Technology, Ankara, Turkey; 2Ankara University School of Pharmacy, Pharmacology, Ankara, Turkey

P-268

Itraconazole-loaded Nanostructured Lipid Carriers (NLC) for pulmonary application in falcons Jana Pardeike 1; Sabrina Weber 1; Hans Peter Zarfl 2; Andreas Zimmer 1 1University of Graz, Pharmaceutical Technology, Graz, Austria; 2Private Veterinary Sugery, Wolfsberg, Austria

P-269

Mucoadhesive hydrogels for the buccal release of chlorhexidine A. Fini 1; V. Bergamante 1; G.C. Ceschel 2 1University of Bologna, Bologna, Italy; 2Monteresearch, Bollate (Mi), Italy

P-270

Mucoadhesive films containing chitosan-coated polycaprolactone nanoparticles: a new strategy for buccal delivery of curcumin Letícia Mazzarino 1; Sonia Ortega Murillo 1; Elenara Lemos-Senna 2; Redouane Borsali 1 1Université Joseph Fourier, Centre de Recherches sur les Macromolécules Végétales, Grenoble, France; 2Universidade Federal de Santa Catarina, Departamento de Ciências Farmacêuticas, Florianópolis, Brazil

P-271

Prediction and optimization of ranitidine release from HPMC matrices by Factorial Design Ivo Múrias 1; Carla M. Lopes 2; Delfim Santos 3; Franscisco Veiga 1; Rita Oliveira 4; Ruggero Bettini 5; Stuart A. Jones 6; Pedro Barata 4 1Faculty of Pharmacy, Coimbra University, Center for Pharmaceutical Studies, Laboratory of Pharmaceutical Technology, Coimbra, Portugal; 2Faculty of Health Sciences, Fernando Pessoa University and CGB-UTAD/IBB, Porto, Portugal; 3Faculty of Pharmacy, Porto University, Laboratory of Pharmaceutical Technology, Porto, Portugal; 4Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal; 5University of Parma, Department of Pharmacy, Parma, Italy; 6King's College London, Pharmaceutical Science Division, London, United Kingdom

P-272

Preparation and characterization of self emulsifying drug delivery system for hydrophobic compound Kumar Ashok 1; P S Gide 2; A G Agrawal 1 1Cachet Pharmaceuticals Pvt. Ltd.,Alkem group, INDIA, Formulation Research and Development, Bhiwadi, Near New Delhi, India; 2MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik – 422 003, India., Principal, Nashik, India

P-273

Comparison of in vitro/in vivo methods for skin penetration/permeation assessment: A diclofenac-diethylamine case study I Jaksic 1; M Lukic 1; B Markovic 2; B Calija 1; J Milic 1; S Savic 1 1Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Belgrade, Serbia; 2Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Belgrade, Serbia

P-274

Dissolution experiments at varying pH in presence of lipid layer to mimic absorption Karl Box 1; Steve Evans 2; John Comer 1; Sam Judge 1 1Sirius Analytical Instruments Limited, R&D, Forest Row, United Kingdom; 2Sirius Analytical Instruments Limited, Sales, Forest Row, United Kingdom

P-275

Use of gastrointestinal simulation technology in predicting ciprofloxacin/antacids interaction A Stojkovic ; J Parojcic ; S Grbic ; Z Djuric Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Belgrade, Serbia

P-276

Assessment whether ABC transporters are involved in the transport of the oxime HI-6 across the blood-brain barrier Marloes Joosen 1; Freek Schrander 2; Dimitri Grossouw 2; Irene Nooijen 2; Maria Vlaming 2; Herman van Helden 1; Heleen Wortelboer 2 1TNO, Rijswijk, Netherlands; 2TNO, Zeist, Netherlands

P-277

Assessment of species differences in the inhibition of the human and murine ABC transporters MDR1 (ABCB1) and Mdr1a (Abcb1a) by registered drugs in vitro Maria Vlaming ; Harm Jansen ; Freek Schrander ; Irene Nooijen ; Heleen Wortelboer TNO, Zeist, Netherlands

P-278

Bioequivalence evaluation of single doses metronidazole formulations: a randomized, open-label, two-period crossover study in healthy adult Brazilian volunteersBioequivalence evaluation of single doses metronidazole formulations: a randomized, open-label, two-period crossover study in healthy adult Brazilian volunteers Marina Silva ; Simone Schramm ; Eunice Kano ; Eunice Koono ; Valentina Porta ; Cristina Serra FCF USP, Sao Paulo, Brazil

P-279

Poloxamer in situ forming hydrogel as delivery system for the local anesthetic ropivacaine ACS Akkari ; DL Silva ; EC de Lima ; DR de Araujo Universidade Federal do ABC, Centro de Ciências Naturais e Humanas, Santo André-SP, Brazil

P-280

Cocrystals screening using rational solution based methods for nitrofurantoin Amjad Alhalaweh 1; Scott Childs 2; Sumod Geroge 1; Syed Rizvi 3; Sitaram Velaga 1 1Health Science, Lulea, Sweden; 2Renovo Research, Atlanta, Sweden; 3Renovo Research, Atlanta, United States

P-282

Grafting of Quercetin on PMMA: new material for pharmaceutical applications OI Parisi ; M Curcio ; G Cirillo ; I Altimari ; UG Spizzirri ; F Puoci ; F Iemma ; N Picci University of Calabria, Pharmaceutical Sciences, Arcavacata di Rende, Italy

P-283

Selection of cryoprotectant by freeze-thaw test for cationic solid lipid nanoparticles S. Doktorovova 1; A. M. Silva 2; C. M. Lopes 3; P. Martins-Lopes 1; E. B. Souto 3 1Insititute of Biotechnology and Bioengineering,Centre of Genomics and Biotechnology, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal; 2Centre for the Research & Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal; 3Faculty of Health Sciences, Fernando Pessoa University and IBB/CGB-UTAD, Porto/Vila Real, Portugal

P-284

Application of zeta potential and particle size measurements to predict quality and stability of drug carrier systems J Dredán 1; N Niczinger 1; R Zelkó 2; J Balogh 2; I Klebovich 1; I Antal 1

1Semmelweis University, Department of Pharmaceutics, Budapest, Hungary; 2Semmelweis University, University Pharmacy Department of Pharmacy Administration, Budapest, Hungary

P-285

Formulation and in vivo study of novel diazabicyclic opioid agonists Paolo Fadda 1; Manca Ilaria 2; Casu Gianluca 3; Reali Roberta 2; Pani Luca 3; Lazzari Paolo 4 1Consorzio Elpro and Neuroscienze PharmaNess S.c.a r.l., POLARIS, Pula (CA), Italy; 2Neuroscienze PharmaNess S.c.a r.l., POLARIS, Pula (CA), Italy; 3CNR-IFT Istituto Farmacologia Traslazionale, POLARIS, Pula (CA), Italy; 4Neuroscienze PharmaNess S.c.a r.l., POLARIS, Pula (CA), Italy, and Dipartimento di Scienze del Farmaco, Università di Sassari, Sassari, Italy

P-286

Effect of microwaves on a nimesulide/BCD solid dispersion C. Cavallari ; A. Fini University of Bologna, Bologna, Italy

P-287

Suitability of a newly developed air fluidization coater for the coating of tablets containing moisture-sensitive drugs C. Cahyadi ; L. W. Chan ; P. W. S. Heng National University of Singapore, Department of Pharmacy, Singapore, Singapore

P-288

The preparation of amorphous solid dispersions of meloxicam: Polymer selection and investigation of KinetiSol® dispersing process parameters Justin R. Hughey 1; Justin M. Keen 1; Chris Brough 2; Sophie Saeger 3; James W. McGinity 1 1The University of Texas at Austin, Department of Pharmaceutics, Austin, TX, United States; 2DisperSol Technologies, LLC, Austin, TX, United States; 3Free University of Berlin, Berlin, Germany

P-289

Spray-coating of fine pharmaceutical particles with Aquacoat in a 5-g batch scale using a novel miniature fluidized-bed process H Ichikawa 1; M Kadota 1; T Ueno 2; N Asai 2; Y Osako 2; S Teratani 3; Y Fukumori 3 1Kobe Gakuin Univeristy, Faculty of Pharmaceutical Sciences, Kobe, Japan; 2Fuji Paudal, Osaka, Japan; 3Kobe Gakuin University, Faculty of Pharmaceutical Sciences, Kobe, Japan

P-290

Controlling biofilm formation with percentage brancher unit in branched polymers Gracie L Kerr ; Dimitrious A Lamprou ; Paul A Hoskisson ; Andrew J Urquhart University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United Kingdom

P-291

Dissolution enhancement of poorly water soluble drugs by co-precipitation in the presence of additives and stabilizers M Khanfar ; M Sheikh Salem Jordan University of Science and Technology, Pharmaceutical Science, Irbid, Jordan

P-292

Determination of Magnesium Stearate from intact tablets using Raman spectroscopy Satu Lakio 1; Henri Salokangas 2; Balázs Vajna 3; István Farkas 3; György Marosi 3; Jouko Yliruusi 1 1University of Helsinki, Division of Pharmaceutical Technology, Helsinki, Finland; 2Orion Pharma, Espoo, Finland; 3Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, Hungary

P-293

Process understanding of drying applied to wet granulation in single-pot equipment G. Mondelli 1; G. Bertuzzi 1; C. Funaro 1; F. Cembali 1; B. Albertini 2; N. Passerini 2 1IMA S.p.A., Active Division, Ozzano dell’Emilia, Bologna, Italy; 2Università di Bologna, Dip. Scienze Farmaceutiche, Bologna, Italy

P-294

A comparative study looking at differing forms of Hyperspectral imaging for polymer identification and isolation Joseph Muench 1; Steven Wren 2; Steven Marshall 3; Clive Wilson 1; Andrew Urquhart 1 1University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United Kingdom; 2AstraZeneca, Macclesfield, United Kingdom; 3University of Strathclyde, Department of Electronic and Electrical Engineering, Glasgow, United Kingdom

P-295

Application of experimental design for desloratadine syrup development J. Pesic 1; I. Homsek 1; S. Ibric 2 1Galenika ad, R&D Institute, Belgrade, Serbia; 2Faculty of Pharmacy, Department of Pharmaceutical Technology, Belgrade, Serbia

P-296

A physiologically-based pharmacokinetic (PBPK) brain model and its application in simulating drug disposition in brain Lu Gaohua 1; Sibylle Neuhoff 1; Masoud Jamei 1; Amin Rostami Hodjegan 2 1Simcyp Limited, Sheffield, United Kingdom; 2University of Manchester, Manchester, United Kingdom

P-297

Interplay of transport and metabolism in the gut: Predictions of drug-drug interactions using physiologically-based pharmacokinetic modelling S Neuhoff 1; K Rowland Yeo 1; M Jamei 1; A Rostami Hodjegan 2 1Simcyp Limited, Sheffield, United Kingdom; 2University of Manchester, Manchester, United Kingdom

P-298

Preparation & characterization of Liquid crystalline structures of naproxen for transdermal delivery Nefise Ozlen Sahin 1; Altan Yuksel 1; Tadeusz Librowski 2 1Mersin University, Faculty of Pharmacy, Department of Biopharmaceutics, Mersin, Turkey; 2Jagellonian University, Faculty of Pharmacy, Department of Pharmacodynamics, Krakow, Poland

P-299

Hydroxiapatite compacts porous based in percolation theory loading with a model drug BM Montóia ; M Ramos ; H Cabral-Marques ; P Salústio Faculdade de Farmácia da Universidade de Lisboa, Departamento de Tecnologia Farmacêutica, Lisboa, Portugal

P-300

The estimation of osmolarity of parenteral solutions using true powder density of the solute Z. Sklubalova Charles University in Prague, Pharmaceutical Technology, Hradec Kralove, Czech Republic

P-301

Optimization of FlexStreamTM— a novel fluid bed processor for granulation P.M. Wong ; P.W.S. Heng National Univeristy of Singapore, Department of Pharmacy, Singapore, Singapore

P-302

The impact of the type and percentage of emollients, as well as the production procedure on the chemical properties of the W/O emulsions created with the natural emulsifier Bojana Vucelic 1; Marija Bajcic 1; Natasa Zivanovic 2 1Pharmacy Belgrade, Laboratory Lipov lad, Belgrade, Serbia; 2Pharmacy Belgrade, Belgrade, Serbia

P-303

Continuous flow crystallization of active pharmaceutical ingredients R Eder 1; J Grill 1; K Schmitt 1; S Schrank 2; E Roblegg 2; M Besenhard 3; S Radl 3; H Gruber-Woelfler 1; J Khinast 1 1Graz University of Technology, Institute for Process and Particle Engineering, Graz, Austria; 2University of Graz, Department of Pharmaceutical Technology, Graz, Austria; 3Research Center Pharmaceutical Engineering, Graz, Austria

P-304

Formulation engineering of nanosuspensions for intravenous administration Cecile Allais ; Stephanie Greco ; Guillaume Louit ; Mostafa Nakach sanofi aventis, Pharmaceutical Sciences, Vitry-sur-Seine, France

P-305

The influence of chitosan-oligosaccharide as crosslinking agent on pH-sensitive drug release from Ca-alginate microparticles B Calija 1; N Cekic 2; S Savic 1; I Masic 1; J Milic 1 1Faculty of Pharmacy, Depratment of Pharmaceutical Technology and Cosmetology, Belgrade, Serbia; 2DCP Hemigal, Leskovac, Serbia

P-306

Biopharmaceutical characterization of mesalazine-loaded chitosan microparticles D Cosco 1; M Vono 1; P Gallelli 1; R Molinaro 1; D Paolino 2; M Fresta 1 1University "Magna Graecia", Department of Pharmacobiological Sciences, Catanzaro, Italy; 2University "Magna Graecia", Department of Experimental and Clinical Medicine, Catanzaro, Italy

P-307

A tandem technique based on prilling and microwave treatments for the production of NSAIDs controlled release dosage forms G Auriemma ; M Ventura ; G Gaudiello ; R.P. Aquino ; P Del Gaudio University of Salerno, Pharmaceutical and Biomediacal Sciences, Fisciano (SA), Italy

P-308

Preparation and properties of inhalable dry powder formulation containing mannitol as excipient for rhIL-2-loaded PLGA microparticles Burcu Devrim ; Asuman Bozkir ; Kandemir Canefe Ankara University Faculty of Pharmacy, Pharmaceutical Technology, Ankara, Turkey

P-309

Preparation and in-Vitro evaluation of Terbinafine-HCl loaded ethosomes for transungual delivery S Tuncay 1; I Vejnovic 2; G Betz 2; O Ozer 1 1Ege University Faculty of Pharmacy, Pharmaceutical Technology, Izmir, Turkey; 2University of Basel Industrial Pharmacy Research Group, Pharmaceutical Sciences, Basel, Switzerland

P-310

Release behavior of sodium diclophenac from cross-linked high amylose/pectin matrices G. A. Soares ; A. D. Castro ; B. S. F. Cury ; R. C. Evangelista Unesp, Drugs and Medicine, Araraquara, Brazil

P-311

Investigating the processing properties of instant release film-coating polymers in aqueous solutions by means of extensional rheology T. Agnese 1; T. Cech 1; W. Dejan 2; N. W. Rottmann 3; F. Soergel 4 1BASF SE, European Pharma Application Lab, Ludwigshafen, Germany; 2Glatt AG, Application Lab, Pratteln, Switzerland; 3BASF SE, Pharma Ingredients & Services Europe, Lampertheim, Germany; 4Thermo Fisher Scientific, Material Characterization, Karlsruhe, Germany

P-312

Investigating the influence of colouring agents on the rheological characteristics of a film-coating dispersion T. Agnese 1; T. Cech 1; N. W. Rottmann 2; F. Soergel 3 1BASF SE, European Pharma Application Lab, Ludwigshafen, Germany; 2BASF SE, Pharma Ingredients & Services Europe, Lampertheim, Germany; 3Thermo Fisher Scientific, Material Characterization, Karlsruhe, Germany

P-313

Investigating mixtures of poloxamer 188 and 407 regarding their gel point and rheologi-cal characteristics of the gel by means of oscillatory measurement T. Agnese 1; T. Cech 1; M. G. Herting 2; F. Soergel 3 1BASF SE, European Pharma Application Lab, Ludwigshafen, Germany; 2BASF SE, Pharma Ingredients & Services Europe, Lampertheim, Germany; 3Thermo Fisher Scientific, Material Characterization, Karlsruhe, Germany

P-314

Investigating the influence of sodium chloride on the gel point of poloxamer formulations by means of oscillatory testing T. Agnese 1; T. Cech 1; M. G. Herting 2; F. Soergel 3 1BASF SE, European Pharma Application Lab, Ludwigshafen, Germany; 2BASF SE, Pharma Ingredients & Services Europe, Lampertheim, Germany; 3Thermo Fisher Scientific, Material Characterization, Karlsruhe, Germany

P-315

investigating the advantages of external lubrication on the tableting process of orally dispersible tablets T. Agnese 1; T. Cech 1; M. Mistry 2; D. Peters 3; C. Poepperl 4 1BASF SE, European Pharma Application Lab, Ludwigshafen, Germany; 2BASF A/S, Pharma Ingredients & Services Europe, Copenhagen, Danmark; 3Fette GmbH, Schwarzenbek, Germany; 4T.G. Ritter Spezialmaschinen GmbH, Netphen, Germany

P-316

Developing a photometric method to determine the amount of film-coating material applied onto individual tablet cores T. Agnese 1; T. Cech 1; F. Guth 2 1BASF SE, European Pharma Application Lab, Ludwigshafen, Germany; 2BASF SE, R&D Project Management Excipients, Ludwigshafen, Germany

P-317

Evaluating different methods to determine the amount of applied coating material onto a tablet T. Agnese 1; T. Cech 1; F. Cembali 2; C. Funaro 2; V. Geiselhart 3; G. Mondelli 4 1BASF SE, European Pharma Application Lab, Ludwigshafen, Germany; 2IMA S.p.A., Process Development and R&D Laboratory, Bologna, Italy; 3BASF SE, Pharma Ingredients & Services Europe, Lampertheim, Germany; 4IMA S.p.A, Process Development and R&D Laboratory, Bologna, Italy

P-318

Determining the minimum amount of functional coat to be applied to gain taste masking functionality and investigating whether tablet shape or scale is influencing the result T. Agnese 1; T. Cech 1; F. Cembali 2; C. Funaro 2; M. Mistry 3; G. Mondelli 2 1BASF SE, European Pharma Application Lab, Ludwigshafen, Germany; 2IMA S.p.A, Process Development and R&D Laboratory, Bologna, Italy; 3BASF A/S, Pharma Ingredients & Services Europe, Copenhagen, Danmark

P-319

Investigating the differences of poorly and hardly soluble actives in a matrix formulation based on polyvinyl acetate by means of tablet characteristics and dissolution properties T. Agnese 1; T. Cech 1; F. Wildschek 2 1BASF SE, European Pharma Application Lab, Ludwigshafen, Germany; 2BASF SE, Pharma Ingredients & Services Europe, Ludwigshafen, Germany

P-320

investigating the influence of various manufacturing technologies on the characteristics and dissolution properties of a matrix tablet based on polyvinyl acetate T. Agnese 1; T. Cech 1; V. Dombos 2; F. Wildschek 3; A. Ruetzler 2 1BASF SE, European Pharma Application Lab, Ludwigshafen, Germany; 2INNOJET Herbert Hüttlin, Application Lab, Steinen, Germany; 3BASF SE, Pharma Ingredients & Services Europe, Ludwigshafen, Germany

P-321

Measuring drug supersaturation in the presence of additives and simulated GI fluids Karl Box 1; John Comer 1; Steve Evans 2; Sam Judge 3 1Sirius Analytical Instruments Limited, R&D, Forest Row, United Kingdom; 2Sirius Analytical Instruments Limited, Sales, Forest Row, United Kingdom; 3Sirius Analytical Instruments Limited, Chemistry, Forest Row, United Kingdom

P-322

Influence of the extrusion temperature on the physical properties of solid dispersions based on a new graft copolymer A Foppoli ; G Loreti ; P Tosoncin ; E Macchi ; M Cerea ; A Gazzaniga Università degli Studi di Milano, Dipartimento di Scienze Farmaceutiche "P.Pratesi", Milano, Italy

P-323

Spray dried nanofibrillated cellulose microparticles as tablet excipient R. Kolakovic 1; L. Peltonen 1; T. Laaksonen 1; K. Putkisto 2; A. Laukkanen 3; J. Hirvonen 1 1University of Helsinki, Faculty of Pharmacy, Division of Pharmaceutical Technology, Helsinki, Finland; 2VTT Technical Research Centre of Finland, Espoo, Finland; 3UPM Nanocenter, Espoo, Finland

P-324

Investigation of tapioca starch as a polymer in controlling sustained release of diclofenac sodium from matrix tablets Doungkamol Leaokittikul Faculty of Pharmaceutical Sciences, Khon Kaen University, Department of Pharmaceutical Technology, Muang Khon Kaen, Thailand

P-325

Characteristics evaluation of special low-viscosity hydroxypropyl cellulose as a novel binder for drug-layering onto fine particles by spouted-bed spraying process Shinichiro Tsue Nippon Soda Co., Ltd, Joetsu-shi, Niigata-ken, Japan

P-326

Advantage to properties and release profile of tablet prepared with a new globular special fine powder of Hydroxypropyl Cellulose by direct compression method Shinichiro Tsue Nippon Soda Co., Ltd, Pharma-Chemicals Division, Niigata-ken, Japan

P-327

Purity of peg 400 affects api and gelatin capsule stability Questions - contact George Rizzo at George.Rizzo@croda.com Abel Pereira Croda International, , United States

P-328

Development of a dissolution method for Ibuprofen chewels™ using a rapid HPLC method Ad Bernaerts ; Bas Heijblom ; Jean-Paul Boon Banner Pharmacaps Europe, Analytical Development R&D, Tilburg, Netherlands

P-329

Spectroscopic NMR studies on the ozonide/hydroperoxide transformation in ozonated oils of pharmaceutical interest L Chiasserini 1; A Sega 1; I Zanardi 1; V Bocci 2; Valter Travagli 1 1Università degli Studi di Siena, Dipartimento Farmaco Chimico Tecnologico, Siena, Italy; 2Università degli Studi di Siena, Dipartimento di Fisiologia, Siena, Italy

P-330

Validation of titrimetric measurement of pKa, logP and solubility using sub-mg quantities of sample Karl Box 1; John Comer 1; Steve Evans 2; Sam Judge 3 1Sirius Analytical Instruments Limited, R&D, Forest Row, United Kingdom; 2Sirius Analytical Instruments Limited, Sales, Forest Row, United Kingdom; 3Sirius Analytical Instruments Limited, Chemistry, Forest Row, United Kingdom

P-331

Continuous Annular Electro-Chromatography - a preparative multi-dimensional separation system for APIs H. Gruber-Woelfler 1; M.-G. Braunbruck 1; P. W. Feenstra 1; R. Laskowski 2; H.-J. Bart 2; J.-G. Khinast 1; Simone Schrank 1 1Graz University of Technology, Institute for Process and Particle Engineering, Graz, Austria; 2Technische Universität Kaiserslautern, Lehrstuhl für Thermische Verfahrenstechnik, Kaiserslautern, Germany

P-332

Contact angle determination: effect of sample preparation S. Acar Kuebart 1; C. M. Keck 2 1Freie Universitaet Berlin, Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Berlin, Germany; 2University Putra Malaysia, Laboratory of Molecular Biomedicine, Institute of Bioscience, Kuala Lumpur-Serdang, Malaysia

P-333

The quantitative analysis for crystal forms in drug product by raman spectroscopy Takashi Yoshioka 1; Akio Ozawa 1; Miyuki Hohokabe 2; Yukihiro Nomura 2; Chiaki Shiraishi 1 1Takeda Pharmaceutical Compony Limited, Analytical Development Laboratories, CMC Center, Osaka, Japan; 2Takeda Pharmaceutical Compony Limited, Pharmaceutical Technology R&D Laboratories, CMC Center, Osaka, Japan

P-334

Characterization of tamarind seed polysaccharides alone and in association with hyaluronic acid I Zanardi 1; V Guastella 1; S Petralito 2; E Paccagnini 3; M Cecchi 1; V Travagli 1 1Università degli Studi di Siena, Dipartimento Farmaco Chimico Tecnologico, Siena, Italy; 2La Sapienza - Università di Roma, Dipartimento di Chimica e Tecnologie del Farmaco, Roma, Italy; 3Università degli Studi di Siena, Dipartimento di Biologia Evolutiva, Siena, Italy

P-335

Hyaluronic Acid of different source and molecular weight: steady-state viscometric evaluations I Zanardi 1; V Rossi 1; V Millucci 2; M Cecchi 3; V Travagli 1 1Università degli Studi di Siena, Dipartimento Farmaco Chimico Tecnologico, Siena, Italy; 2Università degli Studi di Siena, Dipartimento di Fisica, Siena, Italy; 3Farmigea SpA, Pisa, Italy

P-336

Profiling the spectral characteristics of the gums using hyperspectral imaging VE Ronaldson 1; S Karthick 2; N Cairns 3; LA Hodges 4; KA Sime 4; CG Wilson 4 1Bio-Images Research Ltd, Glasgow, United Kingdom; 2Gilden Photonics, Glasgow, United Kingdom; 3Gilden Photonics, Glasgow, United Kingdom; 4Bio-Images Research Ltd, Glasgow, United Kingdom

P-338

Development and validation of a stability-indicating liquid chromatography method for the determination of tigecycline in pharmaceutical product HRN Salgado ; LM Silva UNESP, Drugs and Medicines, Araraquara, Brazil

P-339

Analysis of illegal erectile dysfunction drugs in eastern Thailand Sarunyaporn Kitchaiya ; Jariya Akkarawaranthorn ; Salakchit Chutipongvivate Regional Medical Sciences Center 3, Medical Science, Chonburi, Thailand

P-340

Development and validation of an uv-spectrophotometric method for determination of chlorhexidine digluconate in liquid soap FAM Fiorentino ; JPP Ocanha ; MA Correa ; HRN Salgado UNESP, Drugs and Medicines, Araraquara, Brazil

P-341

Real-time push-broom chemical imaging: a case study of accelerated data processing using GPU C. Finta 1; M. Juuti 1; P. Teppola 1; J. Paaso 2; P. Toivanen 3 1VTT Technical Research Centre of Finland, Photonic Devices and Measurement Solutions, Kuopio, Finland; 2VTT Technical Research Centre of Finland, Photonic Devices and Measurement Solutions, Oulu, Finland; 3University of Easter Finland, School of Computing, Kuopio, Finland

P-364

FBRM as a PAT tool for in-line monitoring of kinetics particle growth in wet granulation processes Firas Alshihabi University of Basel, Pharmaceutical Technology, Basel, Switzerland

P-342

Metabolic transformations observed during in vitro dermal penetration studies Andrew McEwen ; Gill Ford ; Karen Dummer ; Daniel Scott Quotient Bioresearch, Metabolism, Rushden, United Kingdom

P-343

Role of haptoglobin and its polymorphism in bronchial asthma M. Cortez e Castro 1; J. Ferreira 2; M. Pereira-Barbosa 1; M. Bicho 2; C. Marinho 2 1CHLN-HSM, ImmunoAllergy, Lisbon, Portugal; 2Lisbon Medical School, Genetic department, Lisbon, Portugal

P-344

Assessment of genetic diversity in Hyoscyamus sp. using AFLP markers Alireza Etminan 1; Mansour Omidi 2; Eslam Majidi 3; Mohammadreza Naghavi 2; Shamsali Rezazadeh 4; Lia Shooshtari 5; Mansour Ghorbanpour 6; Ardeshir Ghaderi 7; Rahim Taghizadfarid 4 11. Islamic Azad University, Kermanshah branch, Plant breeding, Kermanshah, Islamic Republic of Iran; 2Tehran University, plant breeding, Karaj, Islamic Republic of Iran; 3Islamic Azad University, plant breeding, Tehran, Islamic Republic of Iran; 4Institute of Medicinal Plant(IMP), Pharmacognosy, Karaj, Islamic Republic of Iran; 5Islamic Azad University, Kermanshah, plant breeding, kermanshah, Islamic Republic of Iran; 6Arak University, Medicinal Plants, Arak, Islamic Republic of Iran; 7Institute of Medicinal Plant(IMP), Biotechnology, Karaj, Islamic Republic of Iran

P-345

Study of somaclonal variation in Ducrosia anethifolia as an endangered medicinal plant using AFLP Lia Shooshtari 1; Mansour Omidi 2; Eslam Majidi 3; Mohammadreza Naghavi 2; Shamsali Rezazadeh 4; Alireza Etminan 5; Atena Oladzad 6; Mansour Ghorbanpour 7; Ardeshir Ghaderi 6 1Islamic Azad University, Kermanshah branch, plant breeding, kermanshah, Islamic Republic of Iran; 2Tehran University, plant breeding, karaj, Islamic Republic of Iran; 3Islamic Azad University, plant breeding, tehran, Islamic Republic of Iran; 4Institute of Medicinal Plant(IMP), Pharmacognosy, karaj, Islamic Republic of Iran; 5Islamic Azad University, Kermanshah, plant breeding, kermanshah, Islamic Republic of Iran; 6Institute of Medicinal Plant(IMP), Biotechnology, Karaj, Islamic Republic of Iran; 7Arak University, Medicinal Plants, Arak, Islamic Republic of Iran

P-346

Effect of Single Nucleotide Polymorphisms of ABCB1 gene on the Single-Dose Absorption Pharmacokinetic of Oxcarbazepine Tablets in Healthy Adult Iranian volunteers ss abolmaali ; M bagheri ; AM tamaddon ; sm samani Shiraz university of medical sciences, pharmaceutics, Shiraz, Islamic Republic of Iran

P-348

Buccal investigations of immediate release micro-pellets based on ludiflash® Eva Roblegg 1; Simone Schrank 1; Lisa Lesky 1; Eleonore Fröhlich 2 1Karl Franzens University, Graz, Austria, Institute of Pharmaceutical Sciences, Department Pharmaceutical Technology, Graz, Austria; 2Medical University of Graz, Austria, Center for Medical Research, Graz, Austria

P-349

Finite element model of topical brimonidine distribution in the rabbit eye J Mains 1; C Wilson 1; A Urquhart 1; V Damian-Iordache 2

1University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United Kingdom; 2Glaxosmithkline, King of Prussia, United States

P-350

Prediction of diclofenac pharmacokinetics using early drug discovery in vitro data in a mechanistic dog physiologically-based pharmacokinetic model - "Simcyp Dog". M Harwood 1; D Turner 1; M Jamei 1; A Rostami-Hodjegan 2 1Simcyp Ltd, Sheffield, United Kingdom; 2Simcyp Ltd, Sheffield, UK & University of Manchester, Department of Pharmacy, Manchester, United Kingdom

P-351

Protection against doxorubicin induced cardiotoxicity: An experimental study in rats N Hadi 1; B Mohammad 2 1Kufa Faculty of Medicine, Najaf, Iraq; 2Alqadisiyah college of Medicine, Diwaniya, Iraq

P-352

Blocking leukotrienes pathway ameliorates renal ischemia/ reperfusion injury in a mouse model Najah Hadi ; Fadhil Alamran Medical College Kufa University, Surgical, Najaf, Iraq

P-354

Therapeutic Drug Monitoring (TDM) of antidementia drugs Ralf Koeber 1; Hans-Hermann Kluenemann 2; Reinhold Waimer 3; Anton Koestlbacher 4; Doris Melchner 1; Anett Doerfelt 1; Ekkehard Haen 1 1Clinical Pharmacology/Psychopharmacology, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany; 2Clinical Neuropsychiatric Genetics, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany; 3Gerontopsychiatry, Department of Psychiatry and Psychotherapy, Klinikum Nuremberg Nord, Nuremberg, Germany; 4Department of Information Science, University of Regensburg, Regensburg, Germany

P-355

Covariate based dose estimation equations of pediatric drug using population analysis BY Lee ; IH Baek ; KI Kwon College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea

P-356

Evaluation of community pharmacy based diabetes education program in Turkey Eren yavuz Özbek ; Imren Uca ; Nefise Ozlen Sahin ; Altan Yuksel Mersin University, Faculty of Pharmacy, Biopharmaceutics, Mersin, Turkey

P-357

Detection of drug interactions in hypertensive patients at primary care N Castilla 1; B Calvo 2 1Basque Health Department, Comarca Araba, Vitoria, Spain; 2University of the Basque Country- Faculty of Pharmacy, Pharmacy and Pharmaceutical Technology, Vitoria, Spain

P-358

Drug related problems in polymedicated hypertensive patients B Calvo 1; S Torrent 2 1University of the Basque Country- Faculty of Pharmacy, Pharmacy and Pharmaceutical Technology, Vitoria, Spain; 2Basque Health Department, Comarca Araba, Vitoria, Spain

P-359

Pharmaceutical care in diabetes type 2 A. Mourao ; A. Grabe-Guimaraes ; L. Ev Federal University of Ouro Preto, Ouro Preto, Brazil

P-360

The role of clinical pharmacist in pharmaceutical care of patients with rheumatoid arthritis Oksana Yu. Hrem ; Oksana Ya. Kachmar ; Lyubov Ye. Zaruma Danylo Halytsky Lviv National Medical University, Clinical Pharmacy, Pharmacotherapy and Medical Standardization, Lviv, Ukraine

P-361

Antimicrobial preservation of oral liquid formulations for children R. Embrechts ; Albertina Ariën Janssen Pharmaceutical Companies, Pharmaceutical Development & Manufacturing Sciences, Beerse, Belgium

P-362

Attempt to health risk assessment of pharmaceuticals in drinking water Tetsuji Nishimura 1; Reiji Kubota 1; Maiko Tahara 1; Kumiko Shimizu 1; Norihiro Kobayashi 1; Tomoko Obama 1; Naoki Sugimoto 1; Toshinari Suzuki 2 1National Institute of Health Sciences, Division of Environmental Chemistry, Tokyo, Japan; 2Tokyo Metropolitan Institute of Public Health, Division of Water Quality, Tokyo, Japan

P-363

Aspects of pediatrics pharmacotherapy in Bosnia and Herzegovina and adverse drug events Adnan Bajraktarevic 1; Semira Penava 1; Kaljic Amra Junuzovic 1; Ismet Suljevic 2; Begler Begovic 3; Amina Selimovic 4; Irma Dovadzija 5; Teodora Frankic 5; Dragana Boldic 5; Lutvo Sporisevic 6; Aida Djulepa Djurdjevic 7 1Public Health Institution of Canton Sarajevo Pediatrics Department, Sarajevo, Bosnia and Herzegovina; 2Clinical Medical Center Sarajevo- Department for Biochemistry and Immunology, Sarajevo, Bosnia and Herzegovina; 3Clinical Medical Center Sarajevo- Department for Clinical Pharmacology, Sarajevo, Bosnia and Herzegovina; 4Pediatrics Clinic Sarajevo, Sarajevo, Bosnia and Herzegovina; 5Pharmaceuticals officess of Canton, Sarajevo, Bosnia and Herzegovina; 6First Medical Aid Sarajevo-Pediatrics department, Sarajevo, Bosnia and Herzegovina; 7General Hospital, Sarajevo, Bosnia and Herzegovina