CURRICULUM VITAE Chia-Hung Yen Ph.D. Associate Professor Graduate Institute of Natural Products College of Pharmacy E-mail: chyen@kmu.edu.tw Room N630A, First Teaching Building. Specialty: Molecular Biology, Tumor Biology, Biochemistry, High throughput drug screen. Research Interests: My interests are mainly on developing preventive and therapeutic agents for metabolic disorders, cancer and new emerging pathogens from natural occurring substances and synthetic compounds by using high-throughput and high content screening system.

Our team provide three natural product libraries and high-throughput screening (HTS) services, which are two main components in the NPS Core Laboratory. Currently, there are more than 5,000 plant extracts and 5,000 partial purified fractions in total in these three libraries. The plant materials in our libraries includes Taiwan indigenous plants, plants from the Dr. Cecilia Koo Botanic Conservation Center (KBCC), folk medicinal herbs from Taiwan, Vietnam and Indonesia, and Traditional Chinese Medicine. In addition to natural product libraries, we help collaborators to build up phenotype-based or target-based screening assays. The principle of activity measurement could be based on visible light absorbance, fluorescence/luminescence intensity, or image analyses. Moreover, we can mediate the interaction between service user and natural product chemistry team to promoter further development of screening hits.

In addition to HTS services, my lab works on drug discovery for fatty liver, anti-oxidative response regulation, and influenza infection. Fatty liver, a condition of too much triglyceride fat accumulate in liver cells, can cause the death of hepatocytes and non-alcoholic steatohepatitis (NASH), then lead to hepatic fibrosis and cirrhosis, thus increase the risk of hepatocellular carcinoma (HCC). Non-alcoholic fatty liver disease (NAFLD) has become the most frequent liver disease during the past decades in developed and developing countries. The prevalence of NAFLD is now around 30% in Taiwan and is growing rapidly. Thus, NAFLD is expected to be a huge burden for public health in the future. Therefore, understanding the molecular mechanisms from simple fatty liver to NASH to HCC will contribute to the development of novel diagnostic biomarkers and therapeutic methods. Despite the most efficient treatments are weight loss and exercise, pharmacological strategies are still urgently needed. We utilized a phenotypic assay in

HTS to identify natural products that can reduce lipid accumulation in hepatic cells. We have identified several hit plants, and the active components and their molecular mechanisms of action are currently under investigation.

The nuclear factor erytheroid-derived-2-like 2 (NRF2)‒Kelch-like ECH is the master regulator of redox and xenobiotic sensitive signaling that functions to protect cells against oxidative stress and environmental toxicants through the induction of cytoprotective genes. However, recent genetic analyses of human cancer revealed that NRF2 could be oncogenic and cause resistance to chemotherapy. Moreover, abnormally high expression of NRF2 is frequently seen in human tumor specimen and correlated with poor prognosis. Therefore, we aimed for identification of selected NRF2 regulators that specifically suppress NRF2 function in cancer cells but not in normal cells. Stable NRF2 reporter cells were established in both HCC and immortalized keratinocyte cell lines. Bidirectional NRF2 regulator was identified form a Taiwan indigenous plant by HTS. We also identified several synthetic molecules as normal cell specific NRF2 inducers. In addition to investigate the underlying molecular mechanisms, the discovery of cancer specific NRF2 inhibitors is still in progress.

Influenza A is the major influenza (Flu) causes annual epidemics during winter and causes severe illnesses and deaths for human populations. Influenza viruses mutate frequently, making it difficult to produce a timely and sufficiently effective vaccine to prevent newly emerged influenza, and also making the discovery of novel anti-influenza agents urgent and important. A target based HTS platform was used to identify novel neuraminidase inhibitor. Partial purified plant extracts were found to inhibit wild-type and oseltamivir- and zanamivir-resistant mutant neuraminidase. Currently, the identities of active components are under investigation. Moreover, extracts provided from several collaborators are on the pipeline of screening process, and novel potent inhibitors are expected in near future.

Academic Qualification: 2004.09 - 2009.01 Ph.D., Molecular Medicine Program, Institute of Public Health, School of Medicine, National Yang-Ming University , Taipei, Taiwan. 1999.09 - 2001.11 M.S., Institute of Biochemical Science, College of Science, National Taiwan University, Taipei, Taiwan. 1995.09 - 1999.07 B.Sc., Department of Applied Chemistry, National Chiao-Tung University, Hsinchu, Taiwan. Personal Experiences: 2013 - Assistant Professor, Graduate Institute of Natural Products, College of Pharmacy, KMU, Kaohsiung, Taiwan. 2009.02 - 2013.01 Postdoctoral research associate, Institute of Microbiology and

Immunology, National Yang-Ming University, Taipei, Taiwan. Academic Honors and Awards: 2009 Excellent Award at the Annual Thesis Competition of National Yang-Ming

University 2018 Award of Asia Pacific Society for Biology and Medical Sciences Publications:

1. Mykhailenko O, Korinek M, Ivanauskas L, Bezruk I, Myhal A, Petrikaitė V, El-Shazly M, Lin GH, Lin CY, Yen CH, Chen BH, Georgiyants V, Hwang TL*. Qualitative and Quantitative Analysis of Ukrainian Iris Species: A Fresh Look on Their Antioxidant Content and Biological Activities. Molecules. 2020 Oct 8;25(19):E4588.

2. Yen CH, Hsu CM, Hsiao SY, Hsiao HH*. Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2. Int J Mol Sci. 2020 Sep 14;21(18):6723.

3. Hu HC, Li CY, Tsai YH, Yang DY, Wu YC, Hwang TL, Chen SL, Fülöp F, Hunyadi A, Yen CH, Cheng YB, Chang FR*. Secondary Metabolites and Bioactivities of Aspergillus ochraceopetaliformis Isolated from Anthurium brownii. ACS Omega. 2020 Aug 14;5(33):20991-20999.

4. Kao YT, Chen YS, Tang KW, Lee JC, Tseng CH, Tzeng CC, Yen CH*, Chen YL*. Discovery of 4-Anilinoquinolinylchalcone Derivatives as Potential NRF2 Activators. Molecules. 2020 Jul 8;25(14):3133.

5. Kant R, Lu CK, Nguyen HM, Hsiao HH, Chen CJ, Hsiao HP, Lin KJ, Fang CC, Yen CH*. 1,2,3,4,6 penta-O-galloyl-β-D-glucose ameliorates high-fat diet-induced nonalcoholic fatty liver disease and maintains the expression of genes involved in lipid homeostasis in mice. Biomed Pharmacother. 2020 Sep;129:110348.

6. Wu HC, Cheng MJ, Yen CH, Chen YA, Chen YS, Chen IS, Chang HS*. Chemical Constituents with GNMT-Promoter-Enhancing and NRF2-Reduction Activities from Taiwan Agarwood Excoecaria formosana. Molecules. 2020 Apr 10; 25(7):E1746. (Ranking: 67/172)

7. Yang WS, Lin TY, Chang L, Yeh WW, Huang SC, Chen TY, Hsieh YT, Chen ST, Li WC, Pan CC, Campbell M, Yen CH, Chen YA, Chang PC*. HIV-1 Tat interacts with a Kaposi's sarcoma-associated herpesvirus reactivation-upregulated antiangiogenic long noncoding RNA, LINC00313, and antagonizes its function. J Virol. 2020 Jan 17; 94(3):e01280-19. (Ranking: 8/36)

8. Huang JW, Chen CJ, Yen CH, Chen YA, Liu YP*. Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice. Int J Mol Sci. 2019 Aug 29; 20(17):E4223. (Ranking: 46/172)

9. Tang JY, Li LJ, Ou-Yang F, Wang CL, Shu CW, Wu KH, Wang HR, Yen CH, Cheng YB, Chang HW*. Ethyl Acetate Extract of Nepenthes ventricosa x maxima Exerts Preferential Killing to Oral Cancer Cells. DNA Cell Biol. 2019 Aug; 38(8):763-772. (Ranking: 74/174)

10. Tang JY, Peng SY, Cheng YB, Wang CL, Farooqi AA, Yu TJ, Hou MF, Wang SC, Yen CH, Chan LP, Ou-Yang F, Chang HW*. Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis, and DNA damage against oral cancer cells through oxidative stress. Environ Toxicol. 2019 Aug; 34(8):891-901. (Ranking: 24/91)

11. Yang MH, Liao CC, Hung JH, Lai XT, Yen CH*, Chen YM*. Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene. J. Food Drug Anal. 2019 Apr; 27(2):603-609. (Ranking: 33/133)

12. Kant R†, Yen CH†, Lu CK, Tung CY, Chang PC, Hung JH, Tyan YC, Chen YM*. Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma. Sci Rep. 2019 Feb 13; 9(1):1968. (Ranking: 12/64)

13. Yang MH, Yen CH, Chen YF, Fang CC, Li CH, Lee KJ, Lin YH, Weng CH, Liu TT, Huang SF, The BT, and Chen YM*. Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. Sci Rep. 2019 Feb 22; 9(1):2552. (Ranking: 12/64)

14. Yen CH, Hsiao HH. NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma. Int J Mol Sci. 2018 Nov 7;19(11). pii: E3503. (Ranking: 52/171)

15. Yen CH*, Chang HS, Yang TH, Wang SF, Wu HC, Chen YC, Lin KJ, Wang S. High-Content Screening of a Taiwanese Indigenous Plant Extract Library Identifies Syzygium simile leaf Extract as an Inhibitor of Fatty Acid Uptake. Int J Mol Sci. 2018 Jul 22;19(7). pii: E2130. (Ranking: 52/171)

16. Hung JH, Li CH, Yeh CH, Huang PC, Fang CC, Chen YF, Lee KJ, Chou CH, Cheng HY, Huang HD, Chen M, Tsai TF, Lin AM, Yen CH, Tsou AP, Tyan YC, Chen YA. MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma. Sci Rep. 2018 Aug 16;8(1):12284. (Ranking: 12/64)

17. Liu YP, Chen CH, Yen CH, Tung CW, Chen CJ, Chen YA, Huang MS*. HIV Tat-TIP30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines. Cancer Sci. 2018 Oct;109(10):3105-3114. (Ranking: 66/223)

18. Chou CK, Liu W, Hong YJ, Dahms HU, Chiu CH, Chang WT, Chien CM, Yen CH, Cheng YB and Chiu CC. Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells

through Modulating ER Stress. Int J Mol Sci. 2018 June; 19:1832. (Ranking: 52/171)

19. Yen CH*, Lai CC, Shia TH, Chen M, Yu HC, Liu YP, Chang FR. Gynura divaricata attenuates tumor growth and tumor relapse after cisplatin therapy in HCC xenograft model through suppression of cancer stem cell growth and Wnt/β-catenin signalling. J Ethnopharmacol. 2018 Mar 1;213:366-375. (Ranking: 4/26)

20. Tseeleesuren D, Kant R, Yen CH*, Hsiao HH*, Chen YM*. 1,2,3,4,6-Penta-O-Galloyl-Beta-D-Glucopyranoside Inhibits Proliferation of Multiple Myeloma Cells Accompanied with Suppression of MYC Expression. Front Pharmacol. 2018 Feb 2;9:65. (Ranking: 33/257)

21. Cheng YB, Liu FJ, Wang CH, Hwang TL, Tsai YF, Yen CH, Wang HC, Tseng YH, Chien CT, Chen YA, Chang FR, Wu YC. Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus. Planta Med. 2018 Jan;84(1):49-58. (Ranking: 5/26)

22. Yen CH, Lai CC, Liao CC, Wang SF, Liao YJ, Tung CY, Hung JH, Huang SF, Chen YA. Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development. Sci Rep. 2017 Jun 8;7(1):3052. (Ranking: 10/64)

23. Li CH†, Yen CH†, Chen YF, Lee KJ, Fang CC, Zhang X, Lai CC, Huang SF, Lin HK, Arthur Chen YM. Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma. Int J Cancer. 2017 May 15;140(10):2284-2297. (Ranking: 24/217)

24. Kant R†, Yen CH†, Lu CK, Lin YC, Li JH, Chen YM. Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma. Int J Mol Sci. 2016 May 4;17(5). pii: E669. (Ranking: 52/1637)

25. Wang SF, Wang WH, Chang K, Chen YH, Tseng SP, Yen CH, Wu DC, Chen YM. Severe Dengue Fever Outbreak in Taiwan. Am J Trop Med Hyg. 2016 Jan;94(1):193-7. (Ranking: 4/19)

26. Lin YT†, Yen CH†, Chen HL†, Liao YJ, Lin IF, Chen M, Lan YC, Chuang SY, Hsieh SL, Chen YM. The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients. J Formos Med Assoc. 2015 Jun;114(6):498-503. (Ranking: 46/155)

27. Liao YJ, Fang CC, Yen CH, Hsu SM, Wang CK, Huang SF, Liang YC, Lin YY, Chu YT, Arthur Chen YM. Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications. Int J Cancer. 2015 Sep 15;137(6):1341-51. (Ranking: 31/211)

28. Wang SF, Tseng SP, Huang SW, Yen CH, Hong YW, Chen M, Chen YM. Mitochondria polarization in the contact regions of virus-infected effector cells during cell-to-cell transmission of HIV-1. AIDS Res Hum Retroviruses. 2015 Feb;31(2):175-6. (Ranking: 21/33)

29. Li CH, Lin MH, Chu SH, Tu PH, Fang CC, Yen CH, Liang PI, Huang JC, Su YC, Sytwu HK, Chen YM. Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis. Mol Med. 2015 Mar 24;20:684-96. (Ranking: 20/123)

30. Huang SW, Wang SF, Lin YT, Yen CH, Lee CH, Wong WW, Tsai HC, Yang CJ, Hu BS, Lin YH, Wang CT, Wang JJ, Hu Z, Kuritzkes DR, Chen YH, Chen YM. Patients infected with CRF07_BC have significantly lower viral loads than patients with HIV-1 subtype B: mechanism and impact on disease progression. PLoS One. 2014 Dec 11;9(12):e114441. (Ranking: 8/55)

31. Wang SF, Tseng SP, Yen CH, Yang JY, Tsao CH, Shen CW, Chen KH, Liu FT, Liu WT, Chen YM, Huang JC. Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins. Biochem Biophys Res Commun. 2014 Aug 22;451(2):208-14. (Ranking: 46/74)

32. Lee CM†, Yen CH†, Tzeng TY, Huang YZ, Chou KH, Chang TJ, Arthur Chen YM. Androgen response element of the glycine N-methyltransferase gene is located in the coding region of its first exon. Biosci Rep. 2013 Sep 17;33(5). (Ranking: 141/185)

33. Lin IY†, Yen CH†, Liao YJ, Lin SE, Ma HP, Chan YJ, Chen YM. Identification of FKBP11 as a biomarker for hepatocellular carcinoma. Anticancer Res. 2013 Jun;33(6):2763-9. (Ranking: 146/197)

34. Yen CH, Lin YT, Chen HL, Chen SY, Chen YM. The Multi-functional Roles of GNMT in Toxicology and Cancer. (Invited review article). Toxicol Appl Pharmacol. 2013; 266:67-75. (Ranking: 12/857)

35. Yen CH, Lu YC, Li CH, Lee CM, Chen CY, Cheng MY, Huang SF, Chen KF, Cheng AL, Liao LY, Wu Lee YH and Chen YM. Functional Characterization of Glycine N-methyltransferaseand its Interactive Protein-DEPDC6/DEPTOR in Hepatocellular Carcinoma. Mol Med. 2012; 18:286-296. (Ranking: 25/112)

36. Liu SP, Li YS, Lee CM, Yen CH, Liao YJ, Huang SF, Chien CH, Chen YM. Higher susceptibility to aflatoxin B1-related hepatocellular carcinoma in glycine N-methyltransferase knockout mice. Int J Cancer. 2011; 128:511-523. (Ranking: 32/185)

37. Chen YM, Yen CH, Liu SP, Liao YJ. Response to the Letter to the Editor from Dr. Conrad Wagner. Toxicol Appl Pharmacol. 2009; 237:247. (Ranking: 11/75)

38. Yen CH, Hung JH, Ueng YF, Liu SP, Chen SY, Liu HH, Chou TY, Tsai TF, Darbha R, Hsieh LL, Chen YM. Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect. Toxicol Appl Pharmacol. 2009; 235:296-304. (Ranking: 11/75)

39. Liao YJ, Liu SP, Lee CM, Yen CH, Chuang PC, Chen CY, Tsai TF, Huang SF, Wu Lee TH, Chen YM. Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma. Int J Cancer. 2009; 124: 816-826. (Ranking: 30/143)

Conference abstract:

1. Chia-Hung Yen*. (2019, Aug). The re-emergence of natural products for drug discovery: Experiences in establishment of plant extract libraries for high throughput screening. 2019 19th ThaiTECT Annual Meeting on “Preclinical Research Ecosystem and modified drug development”. Bangkok, Thailand. Invited speaker

2. Duurenjargal Tseeleesuren, Rajni Kant, Chia-Hung Yen*, Hui-Hua Hsiao*, Yi-Ming Arthur Chen*. (2019, Aug). 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranoside suppresses MYC expression and inhibits multiple myeloma cells proliferation. 2019 APBMT annual meeting, Busan, Korea.

3. Chia-Hung Yen*. (2018, Dec). Utilizing plant extract libraries and high-throughput screening for drug discovery. 2018 International Conference for Leading and Young Medical Scientists. Taipei, Taiwan. Invited speaker

4. Chia-Hung Yen*. (2018, Oct). Establishment of plant extract libraries for high-throughput drug screening. 33rd Symposium on Natural Products, Kaohsiung, Taiwan. Invited speaker

5. Chia-Hung Yen*. (2018, Oct). Utilizing high-throughput screen and natural product libraries for drug discovery. 2018 Taiwan High Content Users Meeting. Taipei, Taiwan. Invited speaker

6. Tran Thi Hong Loan, Hsun‐Shuo Chang, Hui‐Hua Hsiao, Chia‐Hung Yen*. (2018, Oct). The methanolic extract of Indigofera suffruticosa Mill. induces G2/M arrest by activation of ATR/CHK1 signaling pathway in Jurkat cells. 2018 the 33rd Symposium on Natural Products, Kaohsiung, Taiwan.

7. Yi Ching Lay, Yi-Ping Kuo, Szu-Yin Yu, Yu-Chan Chao, Sheng-Fan Wang, Yuan-Bin Cheng, Chia-Hung Yen*. (2018, Oct). Screening of a natural products library for anti-influenza virus neuraminidase activity. The 33th Symposium of Natural Products, Kaohsiung, Taiwan.

8. Tsai-Hsun Yang, Hsun-Shuo Chang, Ho-Cheng Wu, Yu-Chang Chen, Kai-Jay Lin, Sheena Wang, Chia-Hung Yen*. (2018, Oct). Identification of Syzygium simile leaves extract with anti-hepatic lipid accumulation activity by high-content screening of a Taiwanese indigenous plant extract library. 2018 the 33rd Symposium on Natural Products, Kaohsiung, Taiwan.

9. Shih Han Wang, Yi Siao Chen, Chung Kuang Lu, Chia Hung Yen*. (2018, Sep). Identification of NRF2 Activator from a Fraction Library of Top-Grade Drugs in Shen Nong Ben Cao Jing. 2018 International Cosmetic-Tech Conference &

Exhibition, Kaohsiung, Taiwan. 10. Chia-Hung Yen*. (2018, May).Utilizing high-throughput screen and natural

product libraries for drug discovery. Joint Symposium on Drug Discovery based on High Throughput Screening and Data Analysis between KMU-NRICM-HCMUT-SoM 2018. Ho Chi Minh City, Vietnam. Invited speaker

11. Yi Siao Chen, Yi Ping Kuo, Chih Chung Lai, Hsun Shuo Chang, Ih Sheng Chen, Chia-Hung Yen*. (2017, Apr). Identification of compound isolated from Beilschmiedia tsangii as a liver cancer specific NRF2 inhibitor. 2017 AACR annual meeting, Washington D.C.

12. Chia-Hung Yen*. (2017, Mar) Identification of PGG as A Glycine N-Methyltransferase Inducer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma. 2017 IBMS-KMU Joint Symposium on Recent Advances in Biomedical Sciences. Kaohsiung, Taiwan. Invited speaker

13. Chih Chung Lai, Tsu-Hsiang Shia, Yu-Peng Liu, Chia-Hung Yen*. (2016, Apr). Low glucose and hypoxia environment promote the enrichment of liver cancer stem cells. AACR Annual Meeting 2016, New Orleans, LA.

14. Rajni Kant, Chia-Hung Yen, Chung Kuang Lu, Chien Yi Tung, Yi-Ming Chen. (2016, Apr). 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside a novel c-Myc inhibitor induces GNMT expression and apoptosis in hepatocellular carcinoma. AACR Annual Meeting 2016, New Orleans, LA.

15. Yen-Fu A. Chen, Kuo-Jui Lee, Yi-Hsiung Lin, Chung-Hsien Li, Chia-Hung Yen, Hui-Kuan Lin, Yi-Ming Chen. (2016, Apr). Identification and characterization of patient-derived PREX2 mutation in HCC. AACR Annual Meeting 2016, New Orleans, LA.

16. Rajni Kant, Lucas Tung, Chung-Kuang Lu, Yi-Ming Chen, Chia-Hung Yen*. (2015, Apr). Identification of novel agent for HCC treatment by GNMT promoter orientated cell-based drug screening platform. AACR Annual Meeting 2015, Philadelphia, PA.

17. Chia-Hung Yen, Rajni Kant, Lucas Tung, Chung-Kuang Lu, Yi-Ming Chen. (2014, Oct). Development of new drugs for prevention and treatment of Hepatocellular carcinoma. 2014 International Conference on Infectious Diseases and Cancer, Kaohsiung. Invited speaker

18. Chia-Hung Yen, Chu-Chung Lai, Chen-Chung Liao, Chien-Yi Tung, and Yi-Ming Arthur Chen (2014, Sep). Establishment and Characterization of Liver Cancer Cell Lines from Gnmt Gene Knockout Mice. International Liver Cancer Association (ILCA) 2014 Annual Conference. Kyoto, Japan.

19. Yen CH, Lu YC, Li CH, Huang SF, Chen YM (2012). Characterization of the Functions of Glycine N-methyltransferase (GNMT) and its Interactive Protein-DEPTOR in the Pathogenesis of Hepatocellular Carcinoma. PTEN Pathways & Targets meeting. Cold Spring Harbor, NY, USA.

20. Li CH, Yen CH, Chen YM (2011). Activation of PI3K pathway by P-RRex2 is

inhibited by GNMT. 13th Society of Chinese Bioscientists in America (SCBA) International Symposium, Guangzhou, China.

21. Lu YC, Yen CH, Lai XT, Chen YM (2011). Phosphorylation of serine 9 is required for benzo(a)pyrene induced GNMT nuclear translocation. The AACR 102nd Annual Meeting, Orlando, USA.

22. Lu YC, Yen CH, Lai XT, Chen YM (2011). Phosphorylation of serine 9 is required for benzo(a)pyrene induced GNMT nuclear translocation. 13th Society of Chinese Bioscientists in America (SCBA) International Symposium, Guangzhou, China.

23. Yen CH, Chen YM (2011). GNMT activates mTOR/Raptor signaling and delays G2/M progression through interacting with DEPTOR. The AACR 102nd Annual Meeting, Orlando, USA.

24. Yen CH, Chen YM (2011). GNMT activates mTOR/Raptor signaling and delays G2/M progression through interacting with DEPTOR. 13th Society of Chinese Bioscientists in America (SCBA) International Symposium, Guangzhou, China.

25. Yen CH, Huang SF, Chen KF, Cheng AL, Liao LY, Chen YM (2011). GNMT expression activates mTOR/Raptor signaling but delays G2/M progression in hepatocellular carcinoma. 2011 Taiwan Digestive Disease Week Satellite Symposium, Taipei, Taiwan. Oral

26. Lee CM, Yen CH, Chen YM (2010). Androgen response element of the glycine N-methyltransferase gene is located in first intron. The AACR 101th Annual Meeting, Washington, DC, USA.

27. Liu SP, Li YS, Lee CM, Yen CH, Liao YJ, Huang SF, Chien CH, Chen YM (2010). Synergistic effects of aflatoxin B1 exposure and glycine Nmethyltransferase deficiency in hepatocarcinogenesis. The AACR 101th Annual Meeting, Washington, DC, USA.

28. Yen CH, Chen YM (2009). Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect. The AACR 100th Annual Meeting, Denver, USA.

Journal reviewer: Archives of Medical Research, 2010 BioMed Research International, 2019 Biotechnology and Applied Biochemistry, 2014 BMC Research Notes, 2011 Clinics in Oncology, 2016 Food and Chemical Toxicology, 2012 Frontiers in Oncology, 2019 Healthcare, 2014 International Journal of Molecular Sciences, 2019 Journal of Biomedical Science, 2011

Journal of Cellular and Molecular Medicine, 2014 Journal of Traditional and Complementary Medicine, 2016, 2017 Molecules, 2016, 2017, 2019 Nutrients, 2019 Oncotarget, 2015, 2016 Oncotargets and Therapy, 2017, 2019 RSC advances, 2016, 2017, 2018 Studies in Natural Products Chemistry, 2016 The Kaohsiung Journal of Medical Sciences, 2016, 2019 Toxicological Sciences, 2009 Patent: 1. Taiwan Patent: A Potential Composition And Its Use For Carcinoma. Patent No.

I626051 2. Taiwan Patent: Treatment Of Liver Cancer With Water Extract Of Gynura

divaricata. Patent No. I661831

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2633-B-

037-001

利用表現 HA7 及 NA9

的桿狀病毒為新型藥物

篩選平台進行抗 H7N9

流感病毒之新藥開發

(2/2)

1050801 1060731 553000 1 個人

型 Y 是 科技部

12 105 N 科技部

(原國科會)

MOST106-

2321-B-

037-002

建立適用於高通量藥物

篩選之天然物純化劃分

層藥庫(1/2)

1060101 1061231 3000000 1 個人

型 Y 是 科技部

13 105

Z 大專學生

研究計畫及

博士後

MOST105-

2811-B-

037-028

博士後研究員--康竣磊 1050901 1060731 768064

9 博士

後研究

員

N 否 科技部

14 104 N 科技部

(原國科會)

MOST104-

2320-B-

037-031-

MY3

氧化還原狀態在肉瘤狀

肝細胞癌形成過程之角

色及在抗肝癌藥物開發

之應用(1/3)

1040801 1070731 1184000 1 個人

型 Y 是 科技部

15 104 N 科技部

(原國科會)

MOST104-

2633-B-

037-001

利用表現 HA7 及 NA9

的桿狀病毒為新型藥物

篩選平台進行抗 H7N9

1040801 1050731 550000 1 個人

型 Y 是 科技部

流感病毒之新藥開發

(1/2)

16 103 N 科技部

(原國科會)

MOST103-

2320-B-

037-016

建立高通量藥物篩選平

台並尋找新型抗脂肪肝

之植物藥暨其有效成分

1030801 1040731 1050000 1 個人

型 N 否