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NADP+

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GAP

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F6P

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Gluc

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NAD+

NAD+

NADH

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Pi

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ATP

ATP

ATP

ATP

ATP

ADP

ADPADP

ADP

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4

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GAP

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10

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red

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red

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HIF (S3)

HIF:ARNT (S5)

HIF:ARNT:HRE (S7)

HIF:PHD (S13)

PHD (S12)Inter-locked

andFragile part

ARNT (S4)

HIF:ARNT:PHD (S15)

HRE (S6)

HIFOH:ARNT:HRE (S22)

HIFOH:ARNT (S16)

HIF:0H(S14) HIFOH:VHL(S18)

VHL (S17)

mRNA

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O2

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independentpathway-1

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S12PHD

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k1

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k12 k14 k18k20

k3

k15 k17

k22

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Caspase−8

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Bax_Bad_Bim

Apoptotic_Stimuli

Bcl−2_Bcl−xL

CytochromeCdATP/ATP

Apaf−1

(m20)

(m22)

Procaspase−9

Caspase−9

Procaspase−3

Caspase−3

DFF

CleavedDFF45DFF40−Oligomer

DNADNA−Fragment

Mitochondrion

s1

s7

s9

s8

s5

s10

s11

s2

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s4

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Procaspase-3

Caspase-3

Mitochondrion

s2

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starch

AMP

ATP

ATP

ATP

ATP

ATP

ATP

ADP29

ADP29

ADP29

ADP

29

ADP29

ADP

29

Pi

28

Pi

28

Pi 28

Pi28

SucTrans

Inv

HK FK

SPP

StaSy(b)

Glyc(b)

ATPcons(b)

PPase

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SPS

PGI

PGMNDPkin

UGPase

AdK

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2928

2

2

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BME TUTORIAL-PART 3 PN-BASED STATIC ANALYSIS OF BIOCHEMICAL NETWORKS

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Transcript of BME TUTORIAL-PART 3 PN-BASED STATIC ANALYSIS OF BIOCHEMICAL NETWORKS