Attitudes About Memory Dampening Drugs Depend on Context and Country
Transcript of Attitudes About Memory Dampening Drugs Depend on Context and Country
Applied Cognitive Psychology, Appl. Cognit. Psychol. 25: 675–681 (2011)Published online 5 August 2010 in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/acp.1740
Attitudes about Memory Dampening Dr
ugs Depend on Context and CountryERYN J. NEWMAN1, SHARI R. BERKOWITZ2, KALLY J. NELSON2, MARYANNE GARRY1
and ELIZABETH F. LOFTUS2*1Victoria University of Wellington, New Zealand2University of California, Irvine, USA
*CorrCrimiof CaE-ma
Copy
Summary: When people take drugs such as propranolol in response to trauma, it may dampen their bad memories – temperingrecall of a traumatic event. We examined people’s attitudes toward these drugs. Americans and New Zealanders read about ahypothetical assault inserting themselves into a scenario as a victim attacked while serving on a peace keeping mission (soldierrole) or while walking home from a job as a restaurant manager (civilian role). Then they told us whether they should receive amemory dampening drug, and whether they would want to take a memory dampening drug. Subjects were negatively disposedtowards a memory dampening drug, but Americans who adopted the soldier role were more in favor of having access to the drugthan those who adopted the civilian role. We discuss the implications of these findings in relation to an increasing trend in‘cosmetic neurology’, medicating with the goal of enhancement, rather than therapy. Copyright # 2010 John Wiley & Sons, Ltd.
Distressing memories do not simply feel terrible in the
moment; they are associated with an array of psychological
consequences, such as dysphoria, depression and low self-
esteem (Berntsen & Rubin, 2006, 2007; Ross & Wilson,
2002). Profoundly distressing memories are a hallmark of
posttraumatic stress disorder (PTSD; APA, 1994). PTSD
produces mental anguish, and significant costs to sufferers,
their families, and society (Kessler, 2000; McNally,
2003a,b). In some cases, people with PTSD come to feel
as though they are haunted by those memories, which can
intrude on their everyday thinking, surface in flashbacks or
nightmares, or set off exaggerated physiological responses.
One Holocaust survivor said his awful memory is ‘in front of
me. I can’t get rid of it’ (Langer, 1993: p. 96; see also Kuch &
Cox, 1992; Wagenaar & Groeneweg, 1990). Similarly,
Berntsen and Rubin (2008) found that Danish tourists who
survived the 2004 Indonesian tsunami experienced intrusive
memories of escaping the wave.
These studies and others suggest that distressing memories
keep us stumbling on unhappiness (with apologies to Gilbert,
2006). One interesting question that arises from this research
is whether people would be interested in taking a drug that
could dampen – that is, lessen the emotion associated with
and diminish content of – a traumatic event? In what context
should people have access to such a drug? These are the
questions we address in the experiment described here.
Given the myriad bad consequences associated with
horrible memories, it is little wonder that scientists have
investigated drugs that might blunt them. Memory dampen-
ing drugs, such as the beta-blocker propranolol, may offer
some relief by disrupting the biological processes that
make emotional memories so intensely remembered in the
first place. Emotionally arousing experiences – positive or
negative – cause the release of adrenal stress hormones
that enhance some aspects of memory (see McGaugh, 2000,
espondence to: Elizabeth F. Loftus, Psychology & Social Behavior,nology, Law& Society, Cognitive Sciences, School of Law, Universitylifornia, Irvine, 2393 Social Ecology II, Irvine, CA 92697-7080 USA.il: [email protected]
right # 2010 John Wiley & Sons, Ltd.
for a review). Propranolol blocks epinephrine receptors,
and in doing so prevents memory enhancement (Cahill,
Prins, Weber, & McGaugh, 1994; McGaugh, 2004). In
a well-known study, Cahill et al. (1994) found that
giving people propranolol destroyed the typical memory
enhancement of emotional experiences, impairing both
recall and recognition of emotional memories relative
to people who did not take propranolol (see also Cahill,
Pham, & Setlow, 2000; Reist, Duffy, Fujimoto, & Cahill,
2001; Roozendaal, Quirarte, & McGaugh, 1997). Taken
together, this research suggests that propranolol can
dampen memory for emotional material and raises
an intriguing question: would propranolol dampen
memories for a traumatic event?
In fact, recent studies suggest that if people take
propranolol after a traumatic experience, they suffer fewer
psychological after-effects. In one study, emergency room
patients took propranolol or a placebo shortly after a
traumatic experience; 1 month later, propranolol patients had
fewer PTSD symptoms than placebo patients (Pitman et al.,
2002). In another study, PTSD patients described their
trauma in writing, and then took propranolol or a placebo.
One week later, patients listened to a recording of their
descriptions while instruments gathered data on their
physiological stress responses. Propranolol patients showed
lower stress responses than placebo patients (Brunet, Orr,
Tremblay, Robertson, Nader, & Pitman, 2008). Although
neither study measured changes in memory, we might
speculate that one mechanism responsible for the reduction
in PTSD symptoms is what Cahill et al. (1994) found:
propranolol makes people remember less, and makes their
emotional memories more like mundane memories.
As advances in neuroscience make access to memory
dampening drugs more likely, some have raised both legal
and ethical concerns about who should have access to them
and in what circumstances (Kolber, 2008; President’s
Council on Bioethics 2003). Moreover, for all the good
memory dampening drugs might do to relieve suffering, we
still do not know if people actually want to take these drugs,
or even want the choice to take them.
1Note that although cell sizes were uneven, for all effects we report, the Fmax
test showed acceptable ratios of cell variances (Tabachnik & Fidell, 2007).
676 E. J. Newman et al.
But there are good reasons to expect that people would
indeed want – at the very least – the choice to take a memory
dampening drug. For one thing, we know that people often
like to have choices. Simply being able to exercise a choice –
rather than being constrained – can result in many positive
psychological outcomes, including boosting feelings of
control and motivation (Iyengar & Lepper, 1999; Szrek &
Baron, 2007; cf. Iyengar & Lepper, 2000). Second, people
tend to overestimate how badly they would feel after a
hypothetical negative event, which may lead them to
overestimate their need for a memory dampening drug.
What leads people to overestimate? Research suggests that
people do not always consider other factors in their lives that
contribute to happiness – instead, they overemphasize the
importance of the target event (Gilbert & Wilson, 2007). In
one study, people who imagined suffering from kidney
disease predicted they would feel quite negative – even
though people who actually suffered from kidney disease
reported feeling positive (Riis, Loewenstein, Baron, Jepson,
Fagerlin, & Ubel, 2005). Taken together, these studies
suggest that people would want to take the drug, or at least
want the choice to take it.
On the other hand, there are also good reasons to expect
that people would want to avoid a memory dampening drug.
For instance, people tend to imagine glowing, positive
futures (Szpunar, 2010; cf. Wilson & Ross, 2003). In one
study, when people generated personally meaningful future
events they were slower at generating negative events than
positive events, and thought the negative events less likely
(Newby-Clark & Ross, 2003). Put another way, positive
future events might come to mind more easily – more
fluently – and therefore feel truer, and more likely (see Alter
& Oppenheimer, 2009 for a review; Sherman, Cialdini,
Schwartzman, & Reynolds, 1985). Considered together, this
research suggests that people may imagine a relatively
positive posttrauma future, and decide they would not need
nor want the drug.
To address these issues, we asked people to read a
scenario about a vicious assault. We manipulated the
circumstances of the assault so that people read about
themselves experiencing one of two similar attacks occurr-
ing in two very different contexts. In the first version, people
read that they were a restaurant manager attacked while
returning from work late at night; in the second version, they
read about the same attack but as a soldier returning to base
late at night.
We also manipulated the base rate of PTSD, telling some
of our subjects that only 4% of people go on to develop PTSD
after a traumatic experience, telling others that the figure was
40%, and telling still others nothing about the base rate of
PTSD. Because the relevant literature is mixed, we had no
specific prediction about the effects of this manipulation. On
the one hand, research leads us to speculate that base rate
information may influence people’s attitudes to memory
dampening drugs. Typically, people believe that others are
more at risk for developing certain medical conditions than
they themselves are (Hansen, Raynor, & Wolkenstein, 1991;
Perloff & Fetzer, 1986; Weinstein, 1984, 1987, see
Weinstein, 1989 for a review). Therefore, it is possible that
feeding people base rate information could counteract their
Copyright # 2010 John Wiley & Sons, Ltd.
sense of invincibility. In other words, it could lead people to
be more concerned that they might develop PTSD and be
more positively disposed towards a memory dampening drug
(seeMenon, Raghubir, & Agrawal, 2008). On the other hand,
some research suggests that base rates often do not affect
people’s attitudes – instead, people overlook base rate
information, focusing on idiosyncratic aspects of an event
(Bar-Hillel, 1980; Tversky & Kahneman, 1974; cf. Ginosar
& Trope, 1987; Koehler, 1996). Therefore, it is possible that
feeding people base rate information might have no influence
on their disposition towards a memory dampening drug.
In the study below, we asked a sample of people in the
United States (US) and New Zealand (NZ) to read the assault
scenarios and then tell us if they wanted the choice to receive
a memory dampening drug, and (assuming they had a choice)
if they would actually want to take it. We expected that
people’s responses might vary by country, reflecting the fact
that Americans are more comfortable with the idea of taking
medication. For instance, people in the US medicate
themselves more than people in any other Organization
for Economic Cooperation and Development (OECD)
nation, spending $121 per person annually on over-the-
counter drugs – more than three times as much as people in
NZ, who spend $40 (OECD Health Data, 2009). When it
comes to prescription drugs, the US again comes out on top,
spending $878 USD per person per year (OECDHealth Data,
2009). By contrast, people in NZ rank 23/24, spending $241
USD per person per year. The comparison is especially
noteworthy, given that the US and NZ are the only OECD
countries permitting direct to consumer prescription drug
advertising (Mintzes et al., 2002).
METHOD
Design
We used a 2 (context: restaurant or military)� 3 (base rate:
4%, 40% or no information)� 2 (country: US or NZ)
between-subjects design. The first factor was context. In the
restaurant condition, people read a version of the assault
scenario that described a restaurant manager returning from
work late at night. In the military condition, people read a
version of the assault scenario describing the same attack
happening to a soldier returning to base late at night.
The second factor was base rate. People read either that
4%, or 40% of people go on to develop PTSD; in the ‘no
information’ version of the scenario, there was no mention of
how often people develop PTSD.
Subjects
A total of 997 people from the community completed the
survey; there were 518 women (52%), 463 men (46%) (16
people did not report gender); they ranged in age from 18 to
80 (M¼ 28.2, SD¼ 13.7). Of the 997 subjects, there were
650 Americans and 347 New Zealanders.1
Appl. Cognit. Psychol. 25: 675–681 (2011)
Attitudes about memory dampening 677
Procedure
We distributed the survey in various parts of southern
California, and Wellington, NZ. People who agreed to take
part completed the survey immediately, and returned it to one
of the experimenters. Each scenario was approximately 100
words long, and varied only in line with the manipulations
described above. For example, people in the restaurant
condition read:
You are a restaurant manager who has just finished work
late at night, and you put the night’s takings in your
backpack so you can deposit them into the restaurant’s
bank account in the morning. Your journey home takes
you through a poorly lit park. While in the park, a man
appears in front of you, and stabs you in the stomach. As
you fall to the ground, he kicks you hard in the ribs, steals
the money and runs off. Although you are badly shaken by
the viciousness of the assault, you are able to get to the
nearest hospital.
People in the military condition read:
You are a soldier on a peacekeeping mission in Afghani-
stan who has just finished patrolling late at night, and you
put the night’s supplies in your pack. Your journey to the
base takes you through dark terrain. While on your way to
the base, a man appears in front of you, and stabs you in
the stomach. As you fall to the ground, he kicks you hard
in the ribs, steals the supplies and your gun and runs off.
Although you are badly shaken by the viciousness of the
assault, you are able to get to the nearest base, where there
is a hospital.
Before reading each scenario, people read a paragraph
describing a drug used to diminish the possible after-effects
of trauma. Although we did not mention propranolol by
name, we based our description of the drug and its effects on
subsequent recall from the scientific literature (Brunet et al.,
2008; Cahill et al., 1994; Pitman et al., 2002). The
paragraphs changed only in respect to the base rate condition.
For example, the 4% version read:
Scientific studies have shown that on average, 4% of
people who experience a traumatic event will develop
PTSD. Some of the debilitating symptoms of PTSD
include recurrent and intrusive distressing recollections
of the event, irritability or outbursts of anger and an
exaggerated startle response. Recently, research has
shown that if a person who has had a traumatic experience
is given a certain drug within a few hours of that experi-
ence, the drug can ‘dampen’ the memory of that event and
minimize the effects of PTSD. In other words, the drug
will lessen the emotion associated with the event, and
diminish factual content for the event, without causing the
complete erasure of the event.
The 40% version replaced 4% with 40%, and people who
read the version with no information read a modified opening
sentence: scientific studies have shown that people who
experience a traumatic event can develop PTSD.
Our primary dependent measures were people’s responses
to two questions: in Question 1 [Q1], people reported the
Copyright # 2010 John Wiley & Sons, Ltd.
extent to which they would want access to a memory
dampening drug, and in Question 2 [Q2], they reported how
likely they would be to actually take the drug if it were made
available. They made their responses on a 5-point Likert type
scale, with anchors 1¼ definitely no to 5¼ definitely yes.
We also asked people for demographic information such as
sex, age and whether or not they had ever witnessed or
experienced a traumatic event.
RESULTS AND DISCUSSION
Our primary interest in this study was to examine whether
people wanted access to memory dampening drugs and
whether they would actually want to take these drugs. We
were also interested in whether the context of trauma
(whether people read about themselves being attacked as a
restaurant manager or a soldier), country of residence and
perceived prevalence of PTSD would affect people’s
attitudes to the drug. Below we focus on two key findings:
the extent towhich peoplewanted the choice to take the drug,
and if they themselves would take the drug. Because we
found that base rate information had no effect on our
findings, we omitted this factor from the analyses below.
Who should have access to the memory dampening
drug?
To examine people’s attitudes about who should have access
to the memory dampening drug, we took their responses to
Q1 and classified them first according to whether they were
from the US or NZ and then by the context in which the
assault occurred. We display those results in Figure 1.
Figure 1 shows three important findings. First, regardless
of where people lived or the hypothetical context in which
they read they were attacked, they showed only modest
desire to have access to the drug. Second, depending on what
country they lived in, the context in which people were
attacked mattered: Americans showed more support for their
right to access the drug if they were the soldier than if they
were the restaurant manager; by contrast, New Zealanders
showed similar support for their right to access the drug when
they were either the restaurant manager or the soldier. Third,
when they adopted the soldier’s point of view, Americans
showed greater support for their right to access the drug than
did New Zealanders.
Statistical support for these findings can be seen in a 2
(context: restaurant ormilitary)� 2 (country: US orNZ) analysis
of variance (ANOVA) which showed a Context�Country
interaction, F(1,996)¼ 4.23, p¼ .04, f¼ .06. Follow-up t-tests
showed that for Americans, the context mattered: the ‘military’
subjects agreedmore strongly that they should have the choice to
take the drug than did the ‘restaurant’ subjects, t(993)¼ 2.78,
p¼ .01, Cohen’s d¼ .18. For New Zealanders, context did not
matter, t(993)¼ .52, p¼ .62. When we focused on just the
military subjects, we found that Americans agreedmore strongly
that they should have access to the drug than did New
Zealanders, t(993)¼ 2.43, p¼ .02, d¼ .15.
We also examined whether people who had experienced a
traumatic event would be more inclined to want access to the
memory dampening drug. Would these people have similar
Appl. Cognit. Psychol. 25: 675–681 (2011)
Figure 1. American and New Zealand responses about access to memory dampening drugs
678 E. J. Newman et al.
attitudes about who should have access to the drug? To assess
this, we analyzed the Q1 responses of the 334 people who
said they had experienced a traumatic event. When we reran
the ANOVA adding traumatic experience (yes, no) as a
factor, we found the same pattern of results. That is, there
was no effect for trauma, F< 1, but there was a
Context�Country interaction, F(1,971)¼ 4.21, p¼ .04,
f¼ .06. Although our conclusions should be taken as
speculative because of the violation of random assignment,
they suggest that experiencing a traumatic event did not
affect people’s attitudes about having access to the drug.
Who would want to take the memory dampening
drug?
Did the effects we found for who should have access to the
drug translate into similar effects when people were asked
whether they themselves would want to take the drug? The
answer is no. As Figure 2 shows, we found no effects for
where people lived or the context in which they were attacked.
Instead, we found that across these factors, people tended to
reject the drugwhen given the choice to take it. In other words,
there was no effect for country, F< 1, no effect for context,
F(1,995)¼ 1.27, p¼ .26 and no interaction, F< 1. Unsurpris-
ingly, the more people agreed that they should have the choice
Figure 2. American and New Zealand response
Copyright # 2010 John Wiley & Sons, Ltd.
about taking the memory dampening drug, the more they
agreed that they would exercise that choice. Put another way,
there was a positive correlation between people’s responses
about having the choice of the drug and their responses about
whether they would take the drug, r(994)¼ .42, p< .01.
Again we wondered if people who had experienced a
traumatic event would have different attitudes towards taking
the memory dampening drug. One possibility is that people
who had experienced a traumatic event would have greater
awareness of its distressing after-effects and be more
inclined to want the drug. To address this possibility, we
reran the ANOVA adding traumatic experience as a factor,
and found that in fact, people who had experienced trauma
were less inclined to take the drug (M¼ 2.10, SD¼ 1.29)
than people who had not experienced trauma (M¼ 2.29,
SD¼ 1.25). The remaining pattern of results was the same.
In other words, a 2 (context: restaurant or military)� 2
(country: US or NZ)� 2 (trauma: yes, no) ANOVA showed
no effect for context, F< 1, no effect for country, F(1,
970)¼ 1.03, p¼ .31, but an effect for trauma, F(1,
970)¼ 5.03, p¼ .02, f¼ .07. This pattern of results held
only for those people who had experienced a traumatic
event. People who had witnessed a traumatic event showed a
similar – although not significant – pattern of responding,
all F’s <1.
s about taking memory dampening drugs
Appl. Cognit. Psychol. 25: 675–681 (2011)
Attitudes about memory dampening 679
Finally, we analyzed the data to determine if age or gender
were related to people’s opinions about wanting access to the
memory dampening drug or exercising that choice. There
was no relationship between age and choice, r(974)¼ .05,
p¼ .14; or age and taking the drug, r(973)¼ .02, p¼ .50.
Men (M¼ 3.34, SD¼ 1.50) and women (M¼ 3.50,
SD¼ 1.41) had similar views on access to the drug
t(979)¼ 1.72, p¼ .09, d¼ .11, but men (M¼ 2.11,
SD¼ 1.28) were less inclined than women (M¼ 2.32,
SD¼ 1.25) to exercise their choice to take the drug
t(978)¼ 2.55, p¼ .01, d¼ .16.
The primary purpose of this research was to examine
people’s attitudes about memory dampening drugs. Taken
together, these data suggest that people generally rejected the
memory dampening drug. In fact, only 54% of people said
they agreed with having the choice to take the drug (rating
four or five on the scale), and an even smaller percentage of
people agreed that they would exercise that choice (18%).
This less than enthusiastic support for the memory
dampening drug fits with the research suggesting that
people readily generate rosy futures in their minds, more
fluently imagining positive events and outcomes than
negative ones (Newby-Clark & Ross, 2003).
Nonetheless, it is possible that people did indeed think
they would experience significantly bad consequences after
the assault, including severe PTSD (Gilbert & Wilson, 2007;
Riis et al., 2005) – yet they rejected the dampening drug
anyway. Why?
One possibility is that such a pattern of results might well
reflect general discomfort about tinkering with our mem-
ories, as depicted in movies such as ‘Eternal Sunshine of
the Spotless Mind’.2 In other words, memory dampening
drugs may threaten people’s sense of their identities. If
memories comprise who we are, then does tinkering with
our memories change who we are (James 1890/1950;
Neisser, 1988; Wilson & Ross, 2003)? Perhaps our subjects
considered this notion.
In addition, we asked people to make a decision about
the drug without knowing if they would ever develop the
negative psychological consequences that would have
warranted their taking the drug; that is, we asked them if
they would take the drug as a preventative measure. Of
course, it is not as though the notion of preventative drugs is
novel – people around the world receive immunizations to
ward off common and rare diseases. Still, perhaps people
would respond differently to a scenario where therapeutic
intervention occurred once people had already developed
PTSD, an approach that is gaining increasing empirical
support (e.g. Brunet et al., 2008; Schiller, Monfils, Raio,
Johnson, LeDoux, & Phelps, 2010). It is also possible that
when people considered the memory dampening drug, they
decided it would be wiser to pursue conventional treatments
for PTSD symptoms first before turning to something new
whose risks are unknown.
Another possibility is that people did not judge the assault
scenario we asked them to read to be a sufficiently significant
trauma; that is, perhaps they would reserve the notion of
‘trauma’ for rape, fires and mass murder – a kind of dose–
2We thank an anonymous reviewer for this notion.
Copyright # 2010 John Wiley & Sons, Ltd.
response model of PTSD. Of course, people’s notions of the
relative impact of comparatively minor and major trauma
are misplaced, as the evidence arguing against a dose–
response model of trauma reactions suggests (see McNally,
2003a).
In many ways, people’s widespread rejection of the drug
was surprising for several reasons. First, we live in an era
where pharmaceutical advancements produce drugs that
would have been viewed as miracles only decades ago, such
as nanoparticles that act like small biochemical weapons,
selectively destroying cancer cells (Murphy et al., 2008). At
the same time, people are increasingly willing to seek out
cosmetic treatments that selectively destroy eyebrow
furrows. In this context, Chatterjee’s (Chatterjee, 2004,
2006) idea of cosmetic neurology reflects a public’s
willingness to selectively destroy or minimize even minor
flaws. On the face of it, then, it is interesting that people were
not more favorable about a memory dampening drug. But as
Riis, Simmons, and Goodwin (2008) showed, although
people said they were willing to take drugs that improved
their attention and concentration, they were less willing to
take drugs that changed more social attributes – such as
anxiety and motivation – that people saw as fundamental to
their identities.
We also found that when Americans adopted the point of
view of a soldier on a peacekeeping mission, they were more
in favor of having access to the drug than when they adopted
the point of view of a restaurant manager suffering a similar
attack on the way home. By contrast, New Zealanders
showed no such effects. In addition, people tended to reject
the notion that they would take the drug themselves,
regardless of the context in which the traumatic experience
occurred, or where they were from.
The fact that Americans who adopted the soldier’s point of
view were more supportive of their right to have access to a
memory dampening drug may reflect factors such as the
difference in how Americans and New Zealanders view
the military. New Zealanders place little emphasis on the
military, as revealed by the small percentage of gross
domestic product (GDP) spent on it (1%) – a value smaller
than its close neighbour Australia (2.4%) and significantly
smaller than the US (4.06%) (Central Intelligence Agency
(CIAWorld Fact Book, 2010); see also Elvy, 2008). In fact, a
recent survey showed that half of New Zealanders were
unwilling to increase spending on defense even though 84%
of people agreed the military was ill-equipped to deal with an
attack (Elvy, 2008).
The attitudes of Americans adopting the soldier’s point of
view do not square with the ethical concerns raised by
scholars and pundits: for example, although the President’s
Council on Bioethics (2003) raised the idea that civilians
who act in defensive public safety roles – police offers,
firefighters and other ‘first responders’ – could have access to
a memory dampening drug, they expressed reservations
about extending the same options to soldiers – who, by
definition, have both offensive and defensive roles (see also
Henry, Fishman, & Youngman, 2007; Kolber, 2006).
Whereas public safety personnel defend against the causes
of trauma, soldiers also create trauma; a drug that dampens
their emotional response to waging war might act to produce
Appl. Cognit. Psychol. 25: 675–681 (2011)
680 E. J. Newman et al.
a ‘killing machine’. There is no evidence that American
subjects shared this concern. Of course, we did not ask them
to take on board specific ethical concerns in making their
decisions – such an approach would be an interesting one,
worthy of future study.
The finding that varying the base rate did not influence
people’s attitudes towards the memory dampening drug fits
with the idea that people tend to overlook information about
base rates (e.g.Bar-Hillel, 1980;Tversky&Kahneman,1974).
In other words, when making their decision, people in our
study may have relied on the context in which the trauma
occurred rather than the prevalence of PTSD. Other research
suggests that people pay attention to information about base
rates only under certain conditions: for example,making event
details seem less diagnostic or even unrelated to a judgment
leads people to heed base rates (Ginosar & Trope, 1980; for a
review see Koehler, 1996). Perhaps a manipulation that
increased the salience of base rates would lead people to be
more concerned about the possibility of getting PTSD and
make them more disposed toward the drug.
How should we make sense of the fact that trauma victims
were less inclined to take the drug? Such a pattern fits with the
idea that trauma memories may serve various adaptive
functions such as providing turning points in someone’s life
and guiding behavior for future events (Krans, Naring,
Becker & Holmes, 2009; Rasmussen & Berntsen, 2009).
Our subjects may have experienced positive growth after a
trauma or come across a situation where the trauma memory
helped them–adifferentpatternof resultsmayhaveemerged if
wehad askedpeoplewhowere currently suffering fromPTSD,
or had recently experienced a trauma (see McNally, 2003b;
Zoellner&Maercker, 2006; see also,Gilbert&Wilson, 2007).
What we do not know is whether a more concrete, detailed
description of trauma-related distress, including intrusive
memories, would give people a better sense of what it would
be like to suffer from these symptoms and thus increase the
likelihood that they would want to take the drug themselves.
We also do not know if people think that memory dampening
drugs would have significant consequences for the justice
system. For example, would they consider testimony
unreliable if given by someone who had taken a memory
dampening drug, or would they be more willing to allow
victims – rather than eyewitnesses – to have access to the
drug? We are currently investigating these questions.
Nietzsche (1980) seemed to embrace the notion of
forgetting when he said ‘Without forgetting, it is quite
impossible to live at all’ (p. 10). The people in our study, on
the other hand, eschewed the notion of forgetting.
ACKNOWLEDGEMENTS
The authors thank Rebecca Bell, Shaun Haywood, students
in PSYC435 at Victoria University of Wellington and
research assistants at the University of California, Irvine
for their invaluable help with data collection. This study was
partially funded by a mini-grant from the University of
California, Office of the President, Pacific Rim Research
Program awarded to Shari R. Berkowitz from the University
of California, Irvine.
Copyright # 2010 John Wiley & Sons, Ltd.
REFERENCES
Alter, A. L., & Oppenheimer, D. M. (2009). Uniting the tribes of fluency to
form a metacognitive nation. Personality and Social Psychology Review,
13, 219–235. 10.1177/1088868309341564.
American Psychiatric Association. (1994). Diagnostic and statistical
manual of mental disorders (DSM-IV). Washington, DC: APA.
Bar-Hillel, M. (1980). The base-rate fallacy in probability judgments. Acta
Psychologica, 44, 211–233. 10.1016/0001-6918(80)90046-3.
Berntsen, D., & Rubin, D. C. (2006). The centrality of event scale. A
measure of integrating trauma into one’s identity and its relation to post-
traumatic stress disorder symptoms. Behavior Research and Therapy, 44,
219–231. 10.1016/j.brat.2005.01.009.
Berntsen, D., & Rubin, D. C. (2007). When trauma becomes key to identity:
Enhanced integration of trauma memories predicts posttraumatic stress
disorder symptoms. Applied Cognitive Psychology, 21, 417–431.
10.1002/acp.1290.
Berntsen, D., & Rubin, D. C. (2008). The reappearance hypothesis revisited.
Memory and Cognition, 36, 449–460. 10.3758/MC.36.2.449.
Brunet, A., Orr, S. P., Tremblay, J., Robertson, K., Nader, K., & Pitman, R. K.
(2008). Effect of post-retrieval propranolol on psychophysiologic
responding during subsequent script-driven traumatic imagery in post-
traumatic stress disorder. Journal of Psychiatric Research, 42, 503–506.
10.1016/j.jpsychires.2007.05.006.
Cahill, L., Pham, C. A., & Setlow, B. (2000). Impaired memory consolida-
tion in rats produced with b-adrenergic blockade. Neurobiology of
Learning and Memory, 74, 259–266. 10.1006/nlme. 1999. 3950.
Cahill, L., Prins, B., Weber, M., & McGaugh, J. L. (1994). Beta-adrenergic
activation and memory for emotional events. Nature, 371, 702–704.
10.1038/371702a0.
Central Intelligence Agency World fact book. (2010). Retrieved on 12
February, 2010, from https://www.cia.gov/library/publications/the-
world-factbook.
Chatterjee, A. (2004). Cosmetic neurology: The controversy over enhancing
movement, mentation, and mood. Neurology, 63, 968–974. Retrieved
from http://www.neurology.org/cgi/content/abstract/63/6/968.
Chatterjee, A. (2006). The promise and predicament of cosmetic neurology.
Journal of Medical Ethics, 32, 110–113. 10.1136/jme.2005.013599.
Elvy, D. (2008). Defence: Exploring the silent consensus. New Zealand
International Review, 33, 23–26. Retrieved from http://www.victoria.
ac.nz/nziia/publications/nzir/2008.html#1.
Gilbert, D. T. (2006). Stumbling on happiness. New York: Knopf.
Gilbert, D. T., &Wilson, T. D. (2007). Prospection: Experiencing the future.
Science, 317, 1351–1354. 10.1126/science.1144161.
Ginosar, Z., & Trope, Y. (1980). The effects of base rates and individuating
information on judgments about another person. Journal of Experimental
and Social Psychology, 16, 228–242. 10.1016/0022-1031(80)90066-9.
Ginosar, Z., & Trope, Y. (1987). Problem solving in judgment under
uncertainty. Journal of Personality and Social Psychology, 52, 464–
474. 10.1037/ 0022-3514. 52.3.464.
Hansen, W. B., Raynor, A. E., & Wolkenstein, B. H. (1991). Perceived
personal immunity to the consequences of drinking alcohol: The relation-
ship between behavior and perception. Journal of Behavioral Medicine,
14, 205–224. 10.1007/BF00845452.
Henry, M., Fishman, J. R., & Youngman, S. J. (2007). Propranolol and the
prevention of post-traumatic stress disorder: Is it wrong to erase the
‘‘sting’’ of bad memories? The American Journal of Bioethics, 7, 12–20.
10.1080/15265160701518474.
Iyengar, S. S., & Lepper, M. R. (1999). Rethinking the value of choice: A
cultural perspective on intrinsic motivation. Journal of Personality and
Social Psychology, 76, 349–366. 10.1037/0022-3514.76.3.349.
Iyengar, S. S., & Lepper, M. R. (2000). When choice is demotivating: Can
one desire too much of a good thing? Journal of Personality and Social
Psychology, 79, 995–1006. 10.1037/0022-3514.79.6.995.
James, W. (1950). Principles of psychology. New York: Dover. [Originally
published in 1890]. 10.1037/11059-000.
Kessler, R. C. (2000). Posttraumatic stress disorder: The burden to the
individual and to society. Journal of Clinical Psychiatry, 61, 4–14.
Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10761674.
Koehler, J. (1996). The base-rate fallacy reconsidered: Descriptive, norma-
tive, and methodological challenges. Behavioral and Brain Sciences, 19,
1–53. 10.1017/S0140525X00041157.
Appl. Cognit. Psychol. 25: 675–681 (2011)
Attitudes about memory dampening 681
Kolber, A. J. (2006). Therapeutic forgetting: The legal and ethical implica-
tions of memory dampening. Vanderbilt Law Review, 59, 1561–1626.
Retrieved from http://law.vanderbilt.edu/publications/vanderbilt-law-
review/archive/volume-59-number-5-october-2006/index.aspx.
Kolber, A. J. (2008). Freedom of memory today. Neuroethics, 1, 145–148.
10.1007/s12152-008-9011-y.
Krans, J., Naring, G., Becker, E. S., & Holmes, E. A. (2009). Intrusive
trauma memory: A review and functional analysis. Applied Cognitive
Psychology, 23, 1076–1088. 10.1002/acp.1611.
Kuch, K., & Cox, B. J. (1992). Symptoms of PTSD in 124 survivors of the
Holocaust. The American Journal of Psychiatry, 149, 337–340. Retrieved
from http://ajp.psychiatryonline.org/cgi/content/abstract/149/3/337.
Langer, L. L. (1993). Holocaust testimonies: The ruins of memory. New
Haven: Yale University Press.
McGaugh, J. L. (2000). Memory – A century of consolidation. Science, 287,
248–251. 10.1126/science.287.5451.248.
McGaugh, J. L. (2004). The amygdala modulates the consolidation of
memories of emotionally arousing experiences. Annual Review of Neuro-
science, 27, 1–28. 10.1146/annurev.neuro.27.070203.1441.
McNally, R. J. (2003a). Progress and controversy in the study of posttrau-
matic stress disorder. Annual Reviews of Psychology, 54, 229–252.
10.1146/annurev.psych.54.101601.145112.
McNally, R. J. (2003b). Does early psychological intervention promote
recovery from posttraumatic stress? Psychological Science in the Public
Interest, 4, 45–79. 10.1111/ 1529-1006. 01421.
Menon, G., Raghubir, P., & Agrawal, N. (2008). Health risk perceptions
and consumer psychology. In C. Haugtveldt, & P. Herr, & F. Kardes
(Eds.), Handbook of consumer psychology. Marketing and consumer
psychology series (pp. 981–1010). New York: Lawrence Erlbaum and
Associates.
Mintzes, B., Barer, M. L., Kravitz, R. L., Kazanjian, A., Bassett, K., Lexchin,
J., et al. (2002). Influence of direct to consumer pharmaceutical advertis-
ing and patients’ requests on prescribing decisions: Two site cross
sectional survey. British Medical Journal, 324, 278–279. 10.1136/
bmj.324.7332.278.
Murphy, E. A., Majeti, B. K., Barnes, L. A., Makale, M., Weis, M. S. M.,
Lutu-Fuga, K., Wrasidlo, W., et al. (2008). Nanoparticle-mediated
drug delivery to tumor vasculature suppresses metastasis. Proceedings
of the National Academy of Sciences, 105, 9343–9348. 10.1073/
pnas.0803728105.
Neisser, U. (1988). Five kinds of self-knowledge. Philosophical Psychology,
1, 35–59. 10.1080/09515088808572924.
Newby-Clark, I. R., & Ross, M. (2003). Conceiving the past and future.
Personality and Social Psychology Bulletin, 29, 807–818. 10.1177/
0146167203029007001.
Nietzsche, F. (1980). On the advantage and disadvantage of history for life.
Indianapolis: Hackett.
Organization for Economic Cooperation and Development (OECD) Health
Data. (2009). Retrieved 11 January, 2010, from http://www.oecd.org/
document/16/0,3343,en_2649_34631_2085200_1_1_1_1,00.html.
Perloff, L. S., & Fetzer, B. K. (1986). Self-other judgments and perceived
vulnerability to victimization. Journal of Personality and Social
Psychology, 50, 502–510. 10.1037/0022-3514.50.3.502.
Pitman, R. K., Sanders, K. M., Zusman, R. M., Healy, A. R., Cheema, F.,
Lasko, N. B., et al. (2002). Pilot study of secondary prevention of
posttraumatic stress disorder with propranolol. Biological Psychiatry,
51, 189–192. 10.1016/S0006-3223(01)01279-3.
President’s Council on Bioethics. (2003). Beyond therapy: Biotechnology and
the pursuit of happiness. Washington, DC: Government Printing Office.
Copyright # 2010 John Wiley & Sons, Ltd.
Rasmussen, A. S., & Berntsen, D. (2009). Emotional valence and the
functions of autobiographical memories: Positive and negative memories
serve different functions. Memory & Cognition, 37, 477–492. 10.3758/
MC.37.4.477.
Reist, C., Duffy, J. G., Fujimoto, K., & Cahill, L. (2001). Beta-adrenergic
blockade and emotional memory in PTSD. The International Journal of
Neuropsychopharmacology, 4, 377–383. 10.1017/S1461145701002607.
Riis, J., Loewenstein, G., Baron, J., Jepson, C., Fagerlin, A., & Ubel, P. A.
(2005). Ignorance of hedonic adaptation to hemodialysis: A study using
ecological momentary assessment. Journal of Experimental Psychology:
General, 134, 3–9. 10.1037/0096-3445.134.1.3.
Riis, J., Simmons, J. P., & Goodwin, G. P. (2008). Preferences for enhance-
ment pharmaceuticals: The reluctance to enhance fundamental traits.
Journal of Consumer Research, 35, 495–508. 10.1086/588746.
Roozendaal, B., Quirarte, G. L., & McGaugh, J. L. (1997). Stress-activated
hormonal systems and the regulation of memory storage. Annals of the
New York Academy of Sciences, 821, 247–258. 10.1111/j. 1749-6632.
1997. tb48284.x.
Ross, M., & Wilson, A. E. (2002). It feels like yesterday: Self-esteem,
valence of personal past experiences, and judgments of subjective
distance. Journal of Personality and Social Psychology, 82, 792–803.
10.1037/0022-3514.82.5.792.
Schiller, D., Monfils, M. H., Raio, C. M., Johnson, D. C., LeDoux, J. E., &
Phelps, E. A. (2010). Preventing the return of fear in humans using
reconsolidation update methods. Nature, 463, 49–53. 10.1038/
nature08637.
Sherman, S. J., Cialdini, R. B., Schwartzman, D. F., & Reynolds, K. D.
(1985). Imagining can heighten or lower the perceived likelihood of
contracting a disease: The mediating effect of ease of imagery. Person-
ality & Social Psychology Bulletin, 11, 118–127. 10.1177/
0146167285111011.
Szpunar, K. (2010). Episodic future thought: An emerging concept.
Perspectives on Psychological Science, 5, 142–162. 10.1177/
1745691610362350.
Szrek, H., & Baron, J. (2007). The value of choice in insurance purchasing.
Journal of Economic Psychology, 28, 529–544. 10.1016/j.joep.
2007.02.003.
Tabachnik, B. G., & Fidell, L. S. (2007). Using multivariate statistics (5th
ed). Boston: Allyn and Bacon.
Tversky, A., & Kahneman, D. (1974). Judgment under uncertainty:
Heuristics and biases. Science, 185, 1124–1131. 10.1126/science.
185.4157.1124.
Wagenaar, W. A., & Groeneweg, J. (1990). The memory of concentration
camp survivors. Applied Cognitive Psychology, 4, 77–87. 10.1002/
acp.2350040202.
Weinstein, N. D. (1984). Why it won’t happen to me: Perceptions of risk
factors and susceptibility. Health Psychology, 3, 431–457. 10.1037/0278-
6133.3.5.431.
Weinstein, N. D. (1987). Unrealistic optimism about susceptibility to health
problems: Conclusions from a community-wide sample. Journal of
Behavioral Medicine, 10, 481–499. 10.1007/BF00846146.
Weinstein, N. D. (1989). Optimistic biases about personal risks. Science,
246, 1232–1233. 10.1126/science.2686031.
Wilson, A. E., & Ross, M. (2003). The identity function of autobiographical
memory: Time is on our side.Memory, 11, 137–149. 10.1080/741938210.
Zoellner, T., & Maercker, A. (2006). Posttraumatic growth in clinical
psychology: A critical review and introduction of a two component
model. Clinical Psychology Review, 26, 626–653. 10.1016/
j.cpr.2006.01.008.
Appl. Cognit. Psychol. 25: 675–681 (2011)