TOPICS OF THE DAY -...
Transcript of TOPICS OF THE DAY -...
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TOPICS OF THE DAY
- Basic Microscopic Anatomy
- Integumentary system
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Berdasarkan ukuran dari bagian yang
dipelajari, anatomi dibagi menjadi :
• Anatomi makroskopik
• Anatomi mikroskopik
( Histologi)
• (nano) [electron microscope]
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Levels of Structural Organization
(Organisasi struktural)
• Atom
• Sel
• Jaringan
• Organ
• System Organ
• Organisme
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UMUM
• Sel unit struktural dan fungsional dr kehidupan
• KOMPONEN (Eukaryotik) : 1. Membran sel
2. Sitoplasma
3. Nucleus
• FUNGSI UTAMA : - pemeliharaan
- pertumbuhan dan perkembangan
- reproduksi
1. Diferensiasi Sel
2. Komunikasi intercelluler : - langsung
- tidak langsung
3. Adhesi sel
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4 Jaringan dasar :
- Epithel menutupi
- Jaringan ikat ―mengikat‖, menghubungan, mengisi
- Otot menggerakkan
- Otot polos
- Otot skeletal
- Otot jantung
- Saraf meneruskan impuls (―pesan‖)
Gambaran &
fungsi khusus
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- Epithel saling melekat erat
- Jaringan ikat sel dan serabut/matriks
- Otot dapat berkontraksi, mengandung
filamen penggerak
- Otot polos
- Otot skeletal
- Otot jantung
- Saraf meneruskan impuls (―pesan‖)
Gambaran &
fungsi khusus
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Epithel
Jaringan ikat
Otot
Syaraf
√
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CIRI UMUM EPITHEL :
• dipisahkan dg jaringan di bawahnya oleh Lamina
basalis /basement membrane
• Avaskular
• melapisi pemukaan luar dan atau dalam
• selnya saling melekat satu sama lain dg
perangkat khusus (Intercellular Junction)
• ruang interseluler sedikit
• terdapat polarisasi
• Dapat terjadi differendiasi pada permukaan sel
ex : microvilli, kinocilia, stereocilia.
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Topografi polarity
• Permukaan lateral (samping)
• Permukaan basal (―bawah‖)
• Peermukaan apikal (―atas‖)
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FUNGSI :
Umum : Membatasi permukaan/dalam cavitas
- TRANSPORT transeluler difusi, karier,
vesikel
- Permeabilitas selektif tight junction (*)
- Absorbsi endocytosis. ex : intestin
- Sekresi exocytosis. ex : kelenjar saliva
- Proteksi. ex : epidermis
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• Selapis:
• Berlapis:
Klasifikasi EPITHEL
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Epithelia Selapis
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Human Anatomy, Larry
M. Frolich, Ph.D.
Epithel Berlapis
• Squamous
– E.g. epidermis
• Transitional
epithelium
– E.g. urinary structures-
-bladder
– Stretches from 6 cells
to 3 cells thick as
bladder fills and
expands
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Kelenjar – Modifikasi dr epithel
Cavity
Ep
1
2
3
A portion of an epithelium grows into the
underlying supporting connective tissue.
The downgrowth develops into a secretory
portion and a duct. This is an exocrine gland.
If the duct disappears, an extensive capillary
network collects the secretions in an „endocrine‟
Gland (4).
4
Klj. exocrine
Klj. endokrin
Epithel
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Epithel
Jaringan ikat
Otot
Syaraf
√
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Mengikat
Membentuk kompartemen
Penunjang
Pelindung
Penyimpanan
Repair
Transpor
FUNGSI :
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• Tidak terpapar lingkungan luar secara
langsung
• Komponen dasar:
(1) specialized cells,
(2) extracellular protein fibers, and
(3) a fluid known as the ground substance
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( klasifikasi)
* KOMPONEN INTERSELULER (= matrix):
Ground substace
Serabut : * kolagen
* elastik
* reticular
* KOMPONEN SELULER
Sel : * fibroblast * Fibrocyte
* Makrofag * Mast cell
* Plasma cell * Adipocyte
* Sel derivat darah
KOMPONEN
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• Fibroblast, Fibrocyte : berfungsi produksi,
sekresi, dan mempertahankan komponen
matrix extrasel
• Mast cell : berperan dlm respon inflamasi
• Makrofag : Fagositosis
• Sel Plasma : pembentukan Antibodi
• Sel Lemak : untuk penyimpanan lemak
• Sel lain derivat darah p.u Lekosit.
(Eosinofil, Limfosit). P.u berperan dalam
sistem imun
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KLASIFIKASI
• Embryonal
• Adult
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Adult
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J.I longgar
J.I padat teratur
J.I padat TIDK teratur
Jaringan ikat sejati
( connective tissue proper)
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Adipose
tissue
Ji Elastik
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Cartilago
osteon
Supporting
connective tissue
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Epithel
Jaringan ikat
Otot
Syaraf
√
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Otot
bergari
s
Otot
Polos
Otot
JANTUNG
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Epithel
Jaringan ikat
Otot
Syaraf √
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Medula
spinalis
cerebrum
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Contoh :
System GIT
terdiri dari organ2 :
Esophagus
Gaster
Duodenum
Jejunum
Ileum
Caecum
System CVS
terdiri dari organ2 :
Jantung
Arteri
Vena
Kapiler
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Contoh :
Pembuluh darah (Arteri dan
vena)
Dilapisi jaringan epithel
selapis pipih di bagian
dalam
Di lapisan tengah dilapisi
jaringan otot polos
Di sisi luar terdapat
jaringan ikat longgar
Dipersarafi oleh jaringan
saraf
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Body organs and structures contain two types
of tissues:
• The parenchymal tissues contain the
functioning cells of an organ or body part
(e.g., hepatocytes, renal tubular cells).
• The stromal tissues consist of the
supporting connective tissues, blood vessels,
and nerve fibers
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Any question ???
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INTEGUMENTARY
System (and its aging manifestation)
Laboratorium Anatomi Histologi
FK UB
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PENDAHULUAN
STRUKTUR
FISIOLOGI
EPIDERMIS
DERMIS
HIPODERMIS
STRUKTUR2 ASESORIS
TIPE
GAMBARAN UMUM
TERMINOLOGY
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• 7 - 8 % total body mass
• Organ terbesar dalam sistem tubuh manusia
• Ketebalan: 1,5 -4,4 mm
• Terdiri dari : kulit dan derivatnya (rambut, kuku, &
kelenjar2)
• Elastis
• Menutupi seluruh permukaan tubuh
• Bervariasi
PENDAHULUAN
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STRUKTUR EPIDERMIS
DERMIS
HIPODERMIS
STRUKTUR2 ASESORIS
TIPE
GAMBARAN UMUM
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GAMBARAN UMUM
Mengandung SEMUA jaringan dasar
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EPIDERMIS • tdd : epithel squamous complex dg kornifikasi
• avascular
• Innervasi : free nerve end tanpa kapsul
• 4 - 5 lapis :
– Str. Corneum : tdd >> lapisan keratinosit mati
– Str. Lucidum ( + )
– Str. Granulosum : berperan dalam mencegah dehidrasi
– Str. Spinosum : beberapa lapis keratinosit dg kecepatan
mitosis lbh rendah. Berperan dlm strength and flexibility
– Str. Basale : supplier keratinocyte str germinativum
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SEL :
– Keratinocyte :
Sel utama
epidermis
Produksi keratin
– Melanocyte :
sintesa melanin
– Langerhans :
berperan dlm sistem
imun
– Merkel :
mechano-receptor
EPIDERMIS
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EPIDERMIS
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EPIDERMIS
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EPIDERMIS
EPIDERMAL
-DERMAL
JUNCTION
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DERMIS
• Jaringan ikat vascular
• dapat membantu regulasi TD & suhu
• >> free nerve end, reseptor sensoris
berkapsul, serabut autonom untuk VSMC
• Mengandung folikel rambut, kelenjar,
pembuluh darah & saraf
• lebih tebal dr epidermis
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• Jaringan ikat irreguler
• lapisan :
– papillary layer : dg anyaman kapiler maintenance
• Ada tonjolan2, dg nerve ending (Meissner)
• Mengandung kapiler
– reticular layer : dg anastomose arteriovenosus
• strength, extensibility & elasticit
• Struktur asesoris
DERMIS (2)
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Sensory Receptor in The Skin
Free nerve
endings
>>fingertips, lips
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• bukan kulit
• tdd j.i longgar dan lemak
• fascia subcutanea / panniculus
adiposus
HYPODERMIS
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TIPE Kulit TEBAL Kulit TIPIS
Lokasi Telapak tangan & kaki Bagian tubuh lain
tebal 0,8 – 1,4 mm 0.07 – 1,12 mm
EPIDERMIS
Str. corneum 15- 40 lapis 10 – 20 lapis
Str. lucidum + p.u -
Str. granulosum Bbrp lapis 1, p.u diskontinu
Str. basale >> Merkel cell <<
dermatoglifi + -
Karakteristik
T I P E
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DERMIS Kulit TEBAL Kulit TIPIS
Rambut - +,
(kcl : glans penis, labia
minora, clitoris,
bibir)
Klj. Cebacea << >>
Klj. Keringat >> <<
Meissner >> <<
Serabut
elastik
<< >>
Dermal-epidermal junction
•Basement membrane, di bawah str. Basale
•Interdigitasi dermal papillae – epidermal ridges
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TEBAL TIPIS
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– hair
– nails
– exocrine glands :
sebacea (lemak),
sudorifera (keringat)
Dr dermis epidermis
STRUKTUR ASESORIUS
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RAMBUT
• Shaft -- visible
• Root -- below the surface
• Follicle surrounds root
– external root sheath
– internal root sheath
– base of follicle is bulb
• blood vessels
• germinal cell layer
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tipe RAMBUT
• Lanugo : 3rd month s.d lahir
• Dewasa :
– Vellus : halus, di hampir seluruh permukaan tubuh
– Intermediate : di extremitas
– Terminal : tebal, lebih berpigmen, kadang ikal.
Termasuk alis dan ―bulu‖ mata
• ! Warna rambut ditentukan oleh densitas melanin di
cortex
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Struktur terkait :
• M. Arrector pili
– smooth muscle in
dermis contracts
with cold or fear.
– forms goosebumps
as hair is pulled
vertically
• glands
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! Perubahan pd
kuku dapat
mengindikasan
adanya suatu
kondisi patologis
(ex : icteric,
cyanosis)
KUKU
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Kelenjar eksokrin
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– PROTEKSI :
• Sbg barrier thd mikroba, toxic subs, radiasi,
benturan, tekanan
• Via sistem imun
– Regulasi suhu tubuh
– Sensoris
– Ekskresi
– Metabolisme vit D (pro-vitamin D berada di kulit)
– ― Water retention‖
Fungsi Umum
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Fungsi Umum
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Sistem Keratinisasi :
• cell renewal (aktivitas mitosis) : di germinativum &
spinosum
• diferensisasi (keratinisasi) : dr germinativum ke atas
• death cell : lucidum ke atas
• Durasi : 15-30 hr secara bergeombang,
• kedalaman & tahap berbeda gambaran berlapis dan
bergelombang
Tahap : (tumpang tindih)
– Mitosis
– Diferensiasi
– Apoptosis
– Exfoliasi
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Faktor :
• pigmen melanin & carotin
• ketebalan epidermis
• pembuluh darah dermis
• warna darah pd pembuluh
• genetik
Melanin
• sintesa oleh melanosit
• macam :
– eumelanin : warna : coklat gelap. Di epidermis, iris,
rambut hitam & coklat
– pheomelanin : warna kuning kemerahan
Sistem Pigmentasi
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• Jumlah melanosit/unit area sama pada semua jenis
warna kulit. Yang membedakan warna kulit :
– Kecepatan sintesa melanin
– Kecepatan akumulasi
– Kecepatan degradasi
• Fungsi melanin
– Perlindungan.
– Cara : absorbsi radikal bebas
Melanosit
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Penyebab2 peningkatan sintesa melanin :
• paparan ultraviolet
• Hormon : MSH, estrogen, ACTH
• Obat2an : chloroquin, khemoterapi
• Polusi : logam berat
• Postinflamasi
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Berdasar sensitivitas terhadap UltraViolet
Always burn, never tan
Always burn, sometimes tan
sometimes burn, sometimes tan
sometimes burn, always tan
Never burn, sometimes tan
Never burn, always tan
Fitzpatrick’s classification
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Terutama akibat pengaruh hormon
Hormon yang terlibat : estrogen, MSH
(meningkat t.u trimester III)
pengaruh :
Melanocyte lebih besar, lebih aktif
Sirkulasi & neovaskularisasi
Klinis :
Melasma gravidarum / Chloasma
Linea nigra
Fisiologi Sistem Integumen dalam Kehamilan
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TISSUE REPAIR
• Jejas jaringan diperbaiki dengan mekanisme :
– regeneration of parenchymal cells
– Connective tissue repair
• Bila regenerasi TIDAK dapat terjadi digantikan
oleh parut jaringan ikat (via connective tissue
repair)
• Melibatkan banyak sel dengan mekanisme
kompleks
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REGENERATION
• Penggantian sel yang hilang oleh sel yang
sama
• Tipe sel Berdasar kemampuan sel regerasi:
– labile
– Stable
– permanent
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• Labile cells terus mbelah & replikasi, seumur
hidup.
• Ex : permukaan sel epithelial kulit, cavum oral,
vagina, and cervix; epithel GIT, UT, & sumsum
tulang
REGENERATION
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• Stable cells biasanya berhenti membelah saat
pertumbuhan berhenti. Regenerasi hanya terjadi
bila ada stimulus yang tepat.
• Contoh : hepatocyte.
REGENERATION
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• Permanent or fixed cells : memiliki kemampuan
mitosis yg sangat terbatas.
• Ex: sel saraf, sel otot skeletal, & otot jantung
REGENERATION
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• jaringan parut (terdiri dr jaringan ikat)
menggantikan sel parenkhim yg tidak
dapat regenerasi
• Dilihat dari luas jaringan yang hilang
primary or secondary intention.
• Luka primary intention dapat mengalami
penyembuhan scr secondary intention.
CONNECTIVE TISSUE REPAIR
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• Terbagi dalam 3 fase:
A. the inflammatory phase (inflamasi),
B. the proliferative phase (proliferasi)
C. the maturational or remodeling phase
(maturasi / remodelling )
CONNECTIVE TISSUE REPAIR
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A. The inflammatory phase • Dimulai saat terjadi jejas
• Mempersiapkan lingkungan untuk
penyembuhan
• Peristiwa : hemostasis, vascular and cellular
phases of inflammation.
• Terjadi awal pembekuan darah (blood clotting)
• Plasma & komponen darah ―bocor‖ pada area
jejas
• Terjadi phagocytosis & pelepasan growth
factors yg menstimulsipertumbuhan sel
epithelial & angiogenesis
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The proliferative phase
• terjadi 2 - 3 hari setelah jejas s.d 3
minggu
• Sel utama yg berperan : fibroblast.
• 24 - 48 jam setelah jejas fibroblasts &
sel endothel pembuluh darah b’proliferasi
membentuk jaringan granulasi.
• Jaringan granulasi berwarna pink, halus,
rapuh, & mudah berdarah
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• Sel epithelial di tepi luka mulai regenerasi
bergerak ke tengah luka, membentuk lapisan
baru yang serupa dengan jaringan awal.
SCAB
• Bila scab sudah terbentuk sel epithell
bermigrasi di antaranya
• ! jaringan granulation berlebihan
menghambat re-epithelialisasi.
• Minggu ke 2, luka mulai samar
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Remodeling Phase
• Mulai + 3 minggu setelah jejas, atau lebih
• Terjadi sintesa collagen o/ fibroblasts
sekaligus lysis o/ enzim collagenase
pembentukan & penguatan scar (jar.parut) !
Pada umumnya tidak bisa pulih 100%.
• Pd secondary intention kontraksi luka
scar lebih mengkerut
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abnormality in healing
• Dapat berupa terbentuknya keloid karena
proses scar tissue repair (parut jaringan ikat)
.
• Penyebab gangguan penyembuhan luka :
– Gangguan aliran darah & oksigenasi
– Gangguan respon iumun & inflamasi
– Infeksi
– Luka terkoyak, benda asing, dan usia
(age factor)
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SKIN VS AGING
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Jenis “Skin aging” • Intrinsic aging – true aging
– Fisiologis, sesuai waktu.
– Banyak dipengaruhi scr genetik
– Cx : kerusakan endogen oleh ROS (reactive oxygen
species), yg dihasilkan dlm metabolisme oksidatif
seluler
• Extrinsic aging
– Krn paparan lingkungan eksternal.
– Ex : p.u UV light ( photoaging). Lain : radiasi ion,
stress fisik dan psikis, alkohol,gizi kurang,obesitas,
polusi lingkungan.
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Intrinsic aging
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Manifestasi :
• Kerutan (Fx : otot, subkutan, gravitasi, tulang, & kartilago)
• Xerosis
• Laxity (longgar)
• Slackness (kendur, tidak elastis)
• Tumor jinak
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• Disebabkan oleh UVB (290–320 nm), dan UVA
(320–400 nm)
• UVB menyebabkan perubahan pada epidermis
merusak DNA pada keratinocytes dan
melanocytes. Lebih bersifat ―membakar‖.
• UVA penetrasi lebih dalam (s.d dermis) ROS.
Lebih berperan dalam photoaging.
• Efek rokok : cigarette skin
Extrinsic aging
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TERMINOLOGY
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Circumscribed, flat,
nonpalpable changes
in skin color
Palpable elevated
solid masses
Circumscribed superficial
elevations of the skin
formed by free fluid in a
cavity within the skin layers
Macula—Small, up to 1 cm.
Example: freckle, petechia
Papule—Up to 0.5 cm.
Example: elevated nevus
Vesicle—Up to 0.5 cm; filled
with serous fluid. Example:
herpes simplex
Patch—Larger than 1 cm.
Example: vitiligo
Nodule—0.5 cm to 1 –2 cm;
often deeper and firmer than
a papule
Bulla—Greater than 0.5 cm;
filled with serous fluid.
Example: 2nd-degree burn
Plaque—A flat, elevated
surface larger than 0.5 cm,
often formed by the
coalescence of papules
Pustule—Filled with pus.
Examples: acne, impetigo
Urtica —A somewhat
irregular,
relatively transient, superficial
area of localized skin edema.
Example: mosquito bite, hive
Tumor—Larger than 1–2 cm
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Generalized plaques
of mycosis
fungoides
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Vesicles of varicella
in different stages
of development
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A small pustule on
the nose
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Petechial rash in
Staph aureus
endocarditis
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Senile
Purpura
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104
Burns
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105
TIPE LUKA BAKAR
• First-degree
– hanya epidermis (sunburn)
• Second-degree burn
– Merusak seluruh epidermis & sebagian dermis
– Bula (blister) yg memisahkan antara epidermis &
dermis
– Derivat epidermal intak
– Sembuh dalam 3 - 4 minggu +/- scar
• Third-degree or full-thickness
– Merusak epidermis, dermis & epidermal derivatives
– Area yang rusak tidak nyeri, krn saraf sensoris
rusak.
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Deskripsi lesi kulit
• ukuran
• bentuk
• warna
• Karakter (lih. Terminology)
• lokasi
• Example: 2.5 cm, circumbscribed, erythematous,
irregularly shaped macule, on the lateral aspect of the
distal right lower extremity
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TERIMA KASIH
Available @ : anatomi.lecture.ub.ac.id