“Rancangan Uji Stabilitas Ibuprofen ”

7/24/2019 Rancangan Uji Stabilitas Ibuprofen

1/11

Kelompok 3

Fepry Harvito, S.Farm. (1520303247)

Feri Andriyanto , S.Farm. (152030324)

Fika !ra"etyanin#r$m , S.Farm. (152030324%)

Finda Farinda , S.Farm. (1520303250)

Fitria Al&i, S.Farm. (1520303251)

PRAKTEK INDUSTRI

Rancangan Uji Stabilitas Ibuprofen


2/11

'$proen

(*!+ 312 -artindale+ 4 F' /+ 541) ama e"mi +'$proen

ama ain +'$proeeni '$pron '$proena" '$prone

'$proeno '$proen$m

ama Kimia + 2(4'"o$tylp6enyl) propioni aid.

$m$" -ol+ 813H92 *- : 20,3

!emerian + "er$k kri"tal, p$ti6 6in##a 6ampir p$ti6, er$ k6a" lema6

Kelar$tan + "an#at m$da6 lar$t dalam etanol, metanol, a"eton dan

kloroorm, "$kar lar$t dalam etil a"etat, prakti" tidak lar$t air

pH + 2

Stailita" + Stail, m$da6 terakar, kompatiel den#an ok"idator k$at

;itik e$r + 757


3/11

!reorm$la"i dr$# 6arateri"ation


4/11

!en#$@ian men$r$t >H9

1. eneral

2. Stre"" te"tin#

3. Seletion o at6e"

4. 8ontainer lo"$re "y"tem

5. Spe"iBation

. ;e"tin# FreC$eny

7. Stora#e ondition

. Staility ommitment%. Dval$ation

10.Statement ? laellin#

11.'n $"e "taility


5/11

!arameter pen#$@ian >H9


6/11

Kela" penyimpanan men$r$t >H9


7/11

!DE'A G'!D8D!A;40


8/11

Standard $rve preparation

'. A &ei#6t o a$rately 100 m# o i$proen &a" taken ?di""olved in 100 ml o 0.1 a9H "ol$tion.( "ol$tion A )

''. From t6e "ol$tion A 10 ml &a" pipette o$t ? dil$ted to100 ml in a vol$metri =a"k &it6 0.1 a9H "ol$tion

( "ol$tion * )'''. From "ol$tion * dierent vol$me" o 0.1 ml, 0.2 ml, 0.4

ml, 0. ml 0. ml ? 1ml &ere taken and dil$ted $p to 10ml &it60.1 a9H "ol$tion.

'/. ;6e a"orane &a" mea"$red at 223 nm in E /

"petrop6otometer a#ain"t 0.1 a9H "ol$tion a" lank.4

/. A #rap6 &a" plotted y takin# onentration /Sa"orane.


9/11

Aelerated "taility "t$die"L Ao$t 100m# o i$proen &a" a$rately &ei#6ed and

tran"erred t6e i$proen into a 250 ml onial =a"k.

L Ao$t 1 or 2 ml alo6ol &a" added to di""olve t6e i$proenand make$p 100ml &it60.1 a9H "ol$tion.

L ;6e onial =a"k &a" orked and kept in &ater at6 at 40M8

L 'mmediately ater plain# in &ater at6, 1ml "ample o miNt$re&a" taken &6i6 repre"ent" Oero time "ample".

L At re#$lar interval o 10, 20,30,40,50 and 0min$te",1 ml o"ample" &ere &it6dra&n rom t6e ontainer and make$p t6evol$me to 10 ml &it6 0.1 a9H "ol$tion

;6e a"orane &a" mea"$red at 223 nm in E /"petrop6otometer a#ain"t a lank.

L A #rap6 &a" plotted y takin# time on N aNi" and lo# perenta"pirin $ndeompo"ed on y aNi".

L ;6e "ame proed$re &a" repeated at 0 M and 70 M

L ;6e "lope" o t6e"e #rap6 &ere al$lated and, Arr6eni$" plot"

&ere made y plottin# lo#arit6m o rate on"tant" a#ain"t t6ereiproal o a"ol$te temperat$re.


10/11

!er$a6an ermakna pada $@i diperepat


11/11

TERIMAKASIM!!N SARAN DAN "IM"IN#ANN$A

“Rancangan Uji Stabilitas Ibuprofen ”

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