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LSM2102 Molecular Biology

Regulation of Eukaryotic geneexpression

Adam Yuan

dbsyya@nus.edu.sgadam@tll.org.sg

mailto:dbsyya@nus.edu.sgmailto:dbsyya@nus.edu.sg

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Main textbook

Alberts et al. (2008) Molecular Biology of

Cell (5th Edition) or (4th Edition, 2002) Chapter 6, How cells read the genome:

from DNA to protein Chapter 7, Control of gene expression.

Chapter 22, Development of multicellularorganisms

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Argonaute structures

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The Nobel Prize in Physiology or Medicine 2006"for their discovery of RNA interference - gene silencing by double-stranded RNA"

Importance of RNA silencing

Andrew Z. Fire Craig C. Mello

RNAi occurs inplants, animals, and humans

Function:Gene expression regulationViral infections defense

Jumping gene control

Biotechnology Tools:Gene function studyNovel therapies in the future

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