DAFTAR ISI

Halaman

DAFTAR ISI.................................................................................................. v

DAFTAR TABEL.......................................................................................... vi

DAFTAR GAMBAR...................................................................................... vii

BAB 1 PENDAHULUAN............................................................................ 1

1.1. Latar Belakang Penelitian...................................................... 1

BAB 2 TINJAUAN PUSTAKA................................................................... 5

2.1. Anatomi dan Fisiologi Ovarium.............................................. 5

2.2. Tumor Ovarium (Neoplasma Ovarium)..............................… 7

2.3. Kanker Ovarium……..........................................................… 8

2.3.1. Epidemiogi dan Faktor Resko Kanker Ovarium.......... 8

2.3.2. Kanker Payudara dan Kanker Ovarium

Berhubungan dengan Herediter Skrining

Genetik ......................................................................... 12

2.3.3. Patogenesis Tumor Ovarium Epitel Ganas................. 13

2.3.4. Jenis Histopatologi Kanker Ovarium Epitel................. 16

2.3.5. Tumor Ovarium Potensi Ganas Rendah .................... 22

2.4. Klasifikasi Histopatologis menurut WHO............................... 22

2.5. Stadium Tumor Ovarium Epitel berdasarkan

International Federatiom of Gynecologist and Obstetricians. 23

2.6. Diagnosis Tumor Ovarium..................................................... 25

2.7. Skrining pada Kanker Ovarium....... ....................................... 26

2.10. ROCA (Risk of Ovarian Cancer Algorithm)........................... 35

2.13. Penatalaksanaan Kanker Ovaium. ......................................... 43

BAB 6 KESIMPULAN.............................................................................. 48

DAFTAR PUSTAKA..................................................................................... 49

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DAFTAR TABEL

Nomor Judul Halaman

Tabel 2.1. Faktor Resiko Berkembangnya Kanker Ovarium Epitel............... 10

Tabel 2.2. Klasifikasi Karsinoma Ovarium berdasarkan WHO..................... 22

Tabel 2.3.Distribusi Kadar HE4.................................................................... 29

Tabel 2.4.Kadar CA 125 pada wanita sehat................................................. 30

Tabel 2.5.Area under cuve (AUC), sensivitas dan spensifitas ROMA RMI

(cut off 200) Sebagai alat diagnostic tumor ovarium epitel........ 31

Tabel 2.6. Area under cuve (AUC), ROMA, CA125 tunggal dan HE4 tunggal

sebagai alat diagnostic tumor ovarium epitel............................. 32

Tabel 2.7.Risk of Ovarian Malignancy Algoritm (ROMA).............................. 33

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DAFTAR GAMBAR

Nomor Judul Halaman

Gambar 2.1. Tiga tipe utama tumor ovarium.............................................. 7

Gambar 2.2. Epidemiologi kanker ovarium................................................ 8

Gambar 2.3. Proses Karsinogenesis Ovarium........................................... 15

Gambar 2.4. Jenis Histopatologi Tumor ovarium epitel.............................. 15

Gambar 2.5. Stadium Kanker Ovarium...................................................... 24

Gambar 2.6. Potongan transversal ovarium pada minggu ke 7

menunjukkan degenerasi sex cords primitive dan

pembentukan cortical cords.(B)Ovarium dan duktus genitalia

pada bulan ke 5 .................................................................... 27

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