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DAFTAR ISI

HALAMAN JUDUL........................................................................................ i

HALAMAN PENGESAHAN ......................................................................... ii

SURAT PERNYATAAN................................................................................. iii

PRAKATA....................................................................................................... iv

DAFTAR ISI …............................................................................................... vii

DAFTAR SINGKATAN ................................................................................. x

DAFTAR TABEL............................................................................................ xi

DAFTAR GAMBAR ....................................................................................... xii

DAFTAR LAMPIRAN.................................................................................... xiii

INTISARI......................................................................................................... xiv

BAB I PENDAHULUAN .......................................................................... 1

1.1. Latar Belakang ...................................................................... 1

1.2. Rumusan Masalah ................................................................. 3

1.3. Tujuan Penelitian ................................................................... 3

1.4. Manfaat Penelitian ................................................................ 4

BAB II TINJAUAN PUSTAKA ................................................................. 5

2.1. MRSA (Metisilin Resisten Staphylococcus aureus) .............. 5

2.1.1. Definisi ....................................................................... 5

2.1.2. Epidemiologi .............................................................. 7

2.1.3. Mekanisme Resistensi… ............................................ 8

2.2. Uji Kepekaan Terhadap Antimikroba .................................... 9

2.2.1. Faktor lingkungan yang berpengaruh terhadap tes

kepekaan..................................................................... 10

2.2.2. Tujuan pengendalian faktor lingkungan..................... 12

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2.2.3. Dasar pemeriksaan uji kepekaan ................................ 13

2.2.4. Metode- metode pengukuran aktifitas antimikroba ... 14

2.3. Disk Cefoxitin………............................................................ 23

2.3.1. Definisi…… ............................................................... 23

2.3.2. Strukur Kimia............................................................. 23

2.3.3. Aktivitas Antimikroba................................................ 24

2.3.4. Mekanisme Resistensi ................................................ 24

2.3.5. Farmakokinetik........................................................... 25

2.3.6. Efek Samping ............................................................. 25

2.3.7. Iindikasi Klinik........................................................... 25

2.3.8. Deteksi MRSA Metode difusi diks cefoxitin…… ..... 25

2.4. Disk Oxacilin ......................................................................... 26

2.4.1. Definisi ....................................................................... 26

2.4.2. Sejarah dan sumber .................................................... 26

2.4.3. Struktur Kimia............................................................ 26

2.4.4. Aktivitas Antimikroba................................................ 27

2.4.5. Mekanisme Resistensi ................................................ 27

2.4.6. Farmakokinetik........................................................... 28

2.4.7. Efek Samping ............................................................. 29

2.4.8. Deteksi MRSA Metode difusi diks oxacilin…… ...... 30

2.5. Kerangka Teori ...................................................................... 31

2.6. Kerangka Konsep .................................................................. 32

2.7. Hipotesis ................................................................................ 32

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BAB III METODE PENELITIAN ............................................................... 33

3.1 Jenis Penelitian....................................................................... 33

3.2 Variabel dan Definisi Operasional ......................................... 33

3.3 Populasi dan Sampel Penelitian ............................................. 35

3.4 Instrumen dan Bahan Penelitian ............................................ 36

3.5 Cara Penelitian ....................................................................... 37

3.6 Tempat dan Waktu Penelitian ................................................ 38

3.7 Analisis Hasil ........................................................................ 39

BAB IV HASIL DAN PEMBAHASAN ....................................................... 40

4.1. Hasil penelitian....................................................................... 40

4.2. Pembahasan............................................................................ 44

BAB V SIMPULAN DAN SARAN............................................................. 47

5.1. Simpulan ................................................................................ 47

5.2. Saran....................................................................................... 47

DAFTAR PUSTAKA .................................................................... ………….. 48