a). obat X dosis 500 mg (IV bolus)

0 2 4 6 8 10 120.0000

0.5000

1.0000

1.5000

2.0000

2.5000

3.0000

3.5000

4.0000

4.5000

f(x) = − 0.304355712488267 x + 4.46734315420476R² = 0.981254150701586

t vs ln Cp

Series2Series4Linear (Series4)Linear (Series4)

time (hour)

Ln C

p

Waktu (hr)Cp (mg/ml) ln cp

1 72 4.27672 51 3.93183 33 3.49654 20 2.99576 14 2.63918 9 2.1972

10 4 1.3863

t 1/2 (jam) = 2.2796K= 0.3040

vd (L)= 5.1240Ln cpo4= .5807

cpo (mg/ml)= 97.5794Cl= 1.5577

t1/2 el = 2.2796AUC = 320.9848

b). obat X dosis 500 (IV bolus)

0 2 4 6 8 10 12 14

-4.0000

-3.0000

-2.0000

-1.0000

0.0000

1.0000

2.0000

3.0000

f(x) = − 0.475634982235308 x + 2.90496948661954R² = 0.999928282601307

t vs in Cp

Series2Linear (Series2)

time (hour)

In C

p

t(jam) Cp(mcg/mL) Ln Cp1 11.43 2.43622 7.13 1.96433 4.38 1.47704 2.64 0.97086 1.06 0.0583

10 0.16 -1.832612 0.06 -2.8134

k 0.4750t1/2 1.4589Ln Cpo 2.9112Cpo (mcg/ml) 18.3796Vd 27.2041Cl 12.9219t1/2elim 1.4589AUC 38.6939

c). Obat Z dosis 300 mg (IV bolus)

0 2 4 6 8 10 12 14

-1.0000

-0.5000

0.0000

0.5000

1.0000

1.5000

2.0000

f(x) = − 0.203593553963987 x + 1.81974596463455R² = 0.998992521289523

t Vs Ln Cp

Series2Linear (Series2)

time

Ln C

p

t(jam) Cp(mcg/mL) Ln Cp1 4.82 1.57282 4.26 1.44933 3.42 1.22964 2.68 0.98586 1.84 0.6098

10 0.81 -0.210712 0.53 -0.6349

k 0.2030t1/2 3.4138Ln Cpo 1.7758Cpo (mcg/ml) 5.9048Vd 50.8057Cl 10.3136t1/2elim 3.4138AUC 29.0879

4). Obat dosis 100 mg (P.O)

Waktu (hr)

Cp (mcg/ml) ln Cp

1 72 4.27672 51 3.93183 33 3.49654 20 2.99576 14 2.63918 9 2.1972

10 4 1.3863

0 2 4 6 8 10 120

0.51

1.52

2.53

3.54

4.5

f(x) = − 0.304355712488267 x + 4.46734315420476R² = 0.981254150701586

t vs Ln Cp

Series2Linear (Series2)

Waktu (hour)

Ln C

p

Ke 0.3040t 1/2 el 2.2796Ln Cp0 4.5807Cp0 97.5794Vd 5.1240

AUC320.984

8Cl 1.5577

e). Obat U dosis 20 mg (P.O)

waktu (hari) Cp (mg/L) Ln Cp Ln C' C' C Res Ln C res0 0 0.0000 0.6170 1.8534 1.8534 0.6170

0.25 0.901 -0.1043 0.5455 1.7255 0.8245 -0.19300.5 1.309 0.2693 0.4740 1.6064 0.2974 -1.2127

0.75 1.526 0.4226 0.4025 1.4956 -0.03041 1.577 0.4555 0.3310 1.3924 -0.1846

1.5 1.429 0.3570 0.1880 1.2068 -0.22223 0.964 -0.0367 -0.2410 0.7858 -0.17826 0.384 -0.9571 -1.0990 0.3332 -0.0508

12 0.062 -2.7806 -2.8150 0.0599 -0.002118 0.01 -4.6052 -4.5310 0.0108 0.000824 0.002 -6.2146 -6.2470 0.0019 -0.0001

10 12 14 16 18 20 22 24 26

-7

-6

-5

-4

-3

-2

-1

0

f(x) = − 0.286165600373762 x + 0.617514413945266R² = 0.998693707345314

t vs Ln C

Series2Linear (Series2)

Waktu (hour)

Ln C

p

Ke 0.2860Ka 3.6590t1/2 el 2.4231AUC 7.2894Vd 43.1704Cl 12.3467

0 0.1 0.2 0.3 0.4 0.5 0.6

-1.5

-1

-0.5

0

0.5

1

f(x) = − 3.65930750305684 x + 0.651937815561623R² = 0.995643489361149

t vs Ln C res

Series2Linear (Series2)

Waktu (hour)

Ln C

Res

0 5 10 15 20 25 300

0.20.40.60.8

11.21.41.61.8

AUC

Series2

Waktu (hour)

Cp

f). Obat V dosis 100 mg (P.O)

Time (hr)

Cp (mg/L) ln Cp

ln C ekstrapolasi

C ekstrapolasi C Res ln C Res

0 0 0 2.731 15.3482 15.3482 2.73100.25 7.514 2.0168 2.6565 14.2463 6.7323 1.90690.5 10.296 2.3318 2.582 13.2236 2.9276 1.0742

0.75 11.039 2.4014 2.5075 12.2742 1.2352 0.21121 11.098 2.4068 2.433 11.3930 0.2950 -1.2207

1.5 9.957 2.2983 2.284 9.8159 -0.14113 6.447 1.8636 1.837 6.2777 -0.16936 2.633 0.9681 0.943 2.5677 -0.0653

12 0.43 -0.8440 -0.845 0.4296 -0.000418 0.071 -2.6451 -2.633 0.0719 0.0009 -7.055624 0.012 -4.4228 -4.421 0.0120 0.0000 -10.7152

y = -0,298x + 2,731R² = 1

ke0.29

8

ka3.35

6

t1/2 eliminasi2.32

55

AUC50.7273

Vd5.95

37

Cl1.77

42

10 12 14 16 18 20 22 24 26

-5-4.5

-4-3.5

-3-2.5

-2-1.5

-1-0.5

0

f(x) = − 0.298239879908301 x + 2.73101980453959R² = 0.999985832719568

T Vs ln Cp

Series2Linear (Series2)

waktu (jam)

ln C

p

0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.80

0.5

1

1.5

2

2.5

3

f(x) = − 3.35681605692829 x + 2.73963840022448R² = 0.999886272111893

t Vs ln C Res

Series2Linear (Series2)

waktu (hr)

0 5 10 15 20 25 300

2

4

6

8

10

12

f(x) = − 0.407551349468341 x + 7.89117640130717R² = 0.48726582544862

AUC

Series2Linear (Series2)

g). Obat W dosis 30 mg (P.O)

h). Obat A dosis 100 mg (P.O)

i). Obat B dosis 25 mg (P.O)

j). Obat C dosis 200 mg (P.O)

k). Obat D dosis 10 mg (P.O)