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Name :David Putra Pradana (103244035)

Heri Prasetyo (103244207)

Biology 2010

New evidence that green tea may help improve bone health

Researchers in Hong Kong are reporting new evidence that green tea oneof the most popular beverages consumed worldwide and now available as adietary supplement may help improve bone health. They found that the teacontains a group of chemicals that can stimulate bone formation and helpslow its breakdown. Their findings are in ACS Journal of Agricultural and

Food Chemistry, a bi-weekly publication. The beverage has the potential tohelp in the prevention and treatment of osteoporosis and other bone diseasesthat affect million worldwide, the researchers suggest.In the new study, Ping Chung Leung and colleagues note that many scientificstudies have linked tea to beneficial effects in preventing cancer, heartdisease, and other conditions. Recent studies in humans and cell culturessuggest that tea may also benefit bone health. But few scientific studies haveexplored the exact chemicals in tea that might be responsible for this effect.

The scientists exposed a group of cultured bone-forming cells (osteoblasts) tothree major green tea components epigallocatechin (EGC), gallocatechin(GC), and gallocatechin gallate (GCG) for several days. They found thatone in particular, EGC, boosted the activity of a key enzyme that promotesbone growth by up to 79 percent. EGC also significantly boosted levels ofbone mineralization in the cells, which strengthens bones. The scientists alsoshowed that high concentrations of ECG blocked the activity of a type of cell(osteoclast) that breaks down or weakens bones. The green tea componentsdid not cause any toxic effects to the bone cells, they note .-- News release courtesy ofAmerican Chemical Society

Main Idea :

Researchers in Hong Kong are reporting new evidence that green tea one of

the most popular beverages consumed worldwide and now available as a dietary

supplement may help improve bone health.

http://www.acs.org/

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Question :

What the green tea contents so that can help improve bone health??

bone-forming cells (osteoblasts) to three major green tea components

epigallocatechin (EGC), gallocatechin (GC), and gallocatechin gallate (GCG)

Whether there are other beneficial effects of drinking green tea??

The beverage has the potential to help in the prevention and treatment of osteoporosis

and other bone diseases

Who the name of the inventor who discovered a new effect of green tea??

Ping Chung Leung in Hongkong

What is the name of the main components of green tea that influence bone

growth??

EGC, boosted the activity of a key enzyme that promotes bone growth by up to 79

percent

What other uses epigallocatechin (EGC) in addition to bone growth??

EGC also significantly boosted levels of bone mineralization in the cells, which

strengthens bones.

Biology Words:

Gallocatechin gallate(GCG) is the ester of gallocatechin and gallic acidand a type of catechin. It is an epimer of EGCG.

In a high temperature environment, an epimerization change is likely to occur,

because heating results in the conversion from EGCG to GCG. According to the

referenced study the resulting CGC (the epimer of EGCG) results in even lower

dietary cholesterol absorption than occurs with EGCG. While this may be a beneficialoutcome with respect to cholesterol reduction activity, for those wishing to maximize

the EGCG content of green tea infusions, it is considered inappropriate to infuse green

tea or its extracts with overheated water.

Gallocatechol or epigallocatechin (EGC) is a flavan triol, a type of

chemicals that contain catechins. This substance is one of the antioxidants found in

food.

This substance is often found in green tea, which is gallocatechin with residue gallat

with the position of the trans isomer. Another source of gallocatechin are persimmon

and pomegranate.

Gallocatechol has the molecular formula C15H14O7 and the molar mass of 306.267 g/ mol.

http://en.wikipedia.org/wiki/Gallocatechinhttp://en.wikipedia.org/wiki/Gallic_acidhttp://en.wikipedia.org/wiki/Catechinhttp://en.wikipedia.org/wiki/Epigallocatechin_gallatehttp://en.wikipedia.org/wiki/Epimerizationhttp://en.wikipedia.org/wiki/Epigallocatechin_gallatehttp://en.wikipedia.org/wiki/Green_teahttp://en.wikipedia.org/wiki/Green_tea

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Epigallocatechin gallate (EGCG), which is also known asepigallocatechin 3-gallate, is a compound and the acid ester of epigallocatechin gallat,

and is a type of catechin. EGCG is a common type of catechin found in tea leaves,

banana leaves, and several other crops, and also a good antioxidant which has the

ability to prevent cancer (Pyrko, 2007) and has the ability of inhibitors for HIV. This

substance is found in green tea, but not present in black tea because EGCG in blacktea turned into thearubigins.