Reactions 1487, p32 - 8 Feb 2014

STelaprevir

Acute kidney injury in an elderly patient: casereport

A 66-year-old woman developed acute kidney injury whilereceiving telaprevir [Telavic] for chronic hepatitis C.

The woman was admitted for treatment of chronichepatitis C, and initiated on combination therapy comprisingpeginterferon-α-2b, ribavirin and telaprevir 2250mg [routeand frequency not stated]. Two days later, she developeddyspnoea, anuria and generalised oedema. Her BP decreasedto 66/36mm Hg, and her peripheral oxygen saturation was79% on room air. Tests showed a creatinine level of7.39 mg/dL, a BUN level of 62.9 mg/dL and a uric acid level of14.4 mg/dL. She was diagnosed with acute kidney injury, andher combination therapy was stopped.

The woman was administered furosemide and oxygensupplementation, with no response. She was moved to theICU and started on continuous venovenoushaemodiafiltration. Her vital signs subsequently improved,and her urine output increased. Haemodiafiltration wasstopped on day 4, when her serum creatinine level reached2.2 mg/dL. She was discharged after 6 days.

Author comment: "We believe that our patient’s [acutekidney injury] was caused by telaprevir used in the treatmentof chronic hepatitis C, because she had previously beentreated with peginterferon and ribavirin."Kikuchi H, et al. Telaprevir-induced acute kidney injury during treatment ofchronic hepatitis C. European Journal of Gastroenterology and Hepatology 26:244-245, No. 2, 2014 - Japan 803099074

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Reactions 8 Feb 2014 No. 14870114-9954/14/1487-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved