Telaprevir
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Reactions 1487, p32 - 8 Feb 2014 S Telaprevir Acute kidney injury in an elderly patient: case report A 66-year-old woman developed acute kidney injury while receiving telaprevir [Telavic] for chronic hepatitis C. The woman was admitted for treatment of chronic hepatitis C, and initiated on combination therapy comprising peginterferon-α-2b, ribavirin and telaprevir 2250mg [route and frequency not stated]. Two days later, she developed dyspnoea, anuria and generalised oedema. Her BP decreased to 66/36mm Hg, and her peripheral oxygen saturation was 79% on room air. Tests showed a creatinine level of 7.39 mg/dL, a BUN level of 62.9 mg/dL and a uric acid level of 14.4 mg/dL. She was diagnosed with acute kidney injury, and her combination therapy was stopped. The woman was administered furosemide and oxygen supplementation, with no response. She was moved to the ICU and started on continuous venovenous haemodiafiltration. Her vital signs subsequently improved, and her urine output increased. Haemodiafiltration was stopped on day 4, when her serum creatinine level reached 2.2 mg/dL. She was discharged after 6 days. Author comment: "We believe that our patient’s [acute kidney injury] was caused by telaprevir used in the treatment of chronic hepatitis C, because she had previously been treated with peginterferon and ribavirin." Kikuchi H, et al. Telaprevir-induced acute kidney injury during treatment of chronic hepatitis C. European Journal of Gastroenterology and Hepatology 26: 244-245, No. 2, 2014 - Japan 803099074 1 Reactions 8 Feb 2014 No. 1487 0114-9954/14/1487-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
Transcript of Telaprevir
Reactions 1487, p32 - 8 Feb 2014
STelaprevir
Acute kidney injury in an elderly patient: casereport
A 66-year-old woman developed acute kidney injury whilereceiving telaprevir [Telavic] for chronic hepatitis C.
The woman was admitted for treatment of chronichepatitis C, and initiated on combination therapy comprisingpeginterferon-α-2b, ribavirin and telaprevir 2250mg [routeand frequency not stated]. Two days later, she developeddyspnoea, anuria and generalised oedema. Her BP decreasedto 66/36mm Hg, and her peripheral oxygen saturation was79% on room air. Tests showed a creatinine level of7.39 mg/dL, a BUN level of 62.9 mg/dL and a uric acid level of14.4 mg/dL. She was diagnosed with acute kidney injury, andher combination therapy was stopped.
The woman was administered furosemide and oxygensupplementation, with no response. She was moved to theICU and started on continuous venovenoushaemodiafiltration. Her vital signs subsequently improved,and her urine output increased. Haemodiafiltration wasstopped on day 4, when her serum creatinine level reached2.2 mg/dL. She was discharged after 6 days.
Author comment: "We believe that our patient’s [acutekidney injury] was caused by telaprevir used in the treatmentof chronic hepatitis C, because she had previously beentreated with peginterferon and ribavirin."Kikuchi H, et al. Telaprevir-induced acute kidney injury during treatment ofchronic hepatitis C. European Journal of Gastroenterology and Hepatology 26:244-245, No. 2, 2014 - Japan 803099074
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Reactions 8 Feb 2014 No. 14870114-9954/14/1487-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
