1st
Workshop on Macromolecular Separations-by-Design
October 10th & 11th, 2012 Gaithersburg, Maryland, USA
October 1
8:00-8:15
8:15-8:30
8:30-9:00
9:00-9:40
9:40-10:2
10:20-10:
10:35-11:
11:15-11:
11:55-1:0
1:05-1:45
1:45-2:25
2:25-2:55
2:55-3:10
3:10-3:50
3:50-4:30
4:30-5:00
6:00
10 – Stateme
Arrive
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15 Peter Ssepara
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8:30-9:00
9:00-9:15
9:15-10:3
10:30-10:
10:45-11:
11:00-12:
12:15-1:1
1:20-2:00
2:00-3:30
3:30
11 – Defining
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Chemical nal Institute
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alkyl-silane or the SEC
hop 2012
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nt on both thwill show the
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g, M. et al. D(2003). g, M. et aly. Science 30
X., Manohar,ion and separ
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d or adsorbedcolloidal pa
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an be regardTs of well-deproblem, we quence and thnventional lty and lengtion develop
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Sciences Diof Standard
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Ming Zheng
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hop 2012
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Group Spokesperson:
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Macromolecular Separations WorkshopBreakout Discussion Topics/Notes
MACROMOLECULAR SEPARATIONS
Critical Polymer Molecule Unknowns: Prioritization
• Quantifying Distributions
• Architecture (Linear, Star, Branched, Cyclic)
• Composition (statistical or block copolymers; blends?)
o Charge/polyelectrolytes?
• Mass (which descriptors? Mn, Mw, Mv?)
• Other
• Rigidity/Aspect ratio /Persistence length?
• Functional assemblies/objects?
• Supramolecular
• Particles and rods/tubes
10
MACROMOLECULAR SEPARATIONS
New Methods and Method Development
• Do you use/develop new methods?
• 2D
• Interactive
• Gradient
• Precipitation-redissolution
• If not, why?
• If so, which ones? What are the limitations? Advantages?
• What the bottlenecks in method development?
• Solvent selection/mixed solvents
• Availability/performance of stationary phases
• Availability of specialized equipment
• Software/data analysis
• Other
MACROMOLECULAR SEPARATIONS
Role of Models, Theory and Data
• Do you use Theory and Simulation tools in your process design and development for macromolecular characterization?
• Why or why not?
• How has it helped you?
• What are the major challenges to adopting stronger connections between calculations and experiment (e.g. language barriers, complexity, etc.)?
• What are the major tools that you use?
• How could they be better?
11
MACROMOLECULAR SEPARATIONS
Validation, Standards and Data
• How do you validate your data? Would best practice guides or different reference materials be important?
• What kinds of new standards would be most useful?
• Would data sharing resources, such as public databases or simply database frameworks, for separations or molecular characterization protocols or raw data that could be public or private be valuable to you?
MACROMOLECULAR SEPARATIONS
Education, Training and Outreach
• Is your workforce adequately trained in polymer/macromolecule separation/characterization science?
• What technical skills are you looking for in new hires (PhD-level) in this general area?
• Are there critical educational/training resources that could be provided at the basic science, fundamental metrology level in new areas of separation science and molecular characterization?
• e.g. Data (mis)interpretation
• Is there a center/facility or other resource an Institute like NIST could provide to accelerate adoption of new methods in industry?
12
A focused leader
in Polyolefin Analysis.
Polymer Char is devoted to the development of state-of-the-art instrumentation
for the characterization of polyolefins.
The company offers a broad range of modern instruments and services for polymer
analysis and more specifically, for structural characterization of polyolefins, such as
Molar Mass Distribution - GPC/SEC (GPC-IR, GPC One), Chemical Composition
Distribution (CRYSTAF, TREF, CEF), Bivariate Distribution by Cross-Fractionation
Chromatography (CFC), High Temperature HPLC (TGIC, SGIC 2D), Xylene Solubles
(CRYSTEX), Preparative Fractionation (PREP mc2) or Infrared Detection (IR4, IR5 MCT).
Polymer Char is also well known for its advanced approach into virtual
instrumentation software that, together with excellent remote control capabilities and
its strong commitment to Customer success, places the company at the leading
edge on instrumentation diagnostics and technical support.
Polymer Char, together with its global network of partners and distributors, supplies,
trains and supports Customers worldwide. The company provides analytical services
in 35 countries and its instruments are present today in over 20 countries within the
Americas, Europe, Africa, Middle East and Asia Pacific, predominantly serving to
Polymer Producers and Processors, Government and Academic Research Laboratories,
Contract Research Organizations, Analytical and Testing Laboratories and Chemical
Instrumentation Manufacturers.
In the last two decades and with an average annual investment of 30% of its
manpower resources on R&D, Polymer Char has played a key-role in the development
of most of the existing polyolefin characterization technologies, such as CRYSTAF,
CRYSTEX, CEF, CFC or GPC with IR detection. Each new project, each new analysis,
makes clearer Polymer Char recognition as The Polyolefin Characterization Company.
Find out more about us at www.polymerchar.com
Corporate Overview
Polymer Characterization, S.A. Gustave Eiffel, 8 Paterna T.: +34 96 131 81 20 [email protected]
E-46980 Valencia, Spain F.: +34 96 131 81 22 www.polymerchar.com
MAIN SOLUTIONS · High Temperature GPC-IR®:
The GPC-IR® instrument is a reliable and fully automated 4D
Gel Permeation Chromatography (GPC) system dedicated to
the characterization of polyolefins. It incorporates the best
infrared (IR) detectors, for the most comprehensive
characterization of polymers such us HDPE, PP, LDPE, LLDPE,
EP copolymers, EVA, EBA or others in the group of polyolefins,
with the add-on of providing composition information as well.
· CRYSTAF-TREF:
CRYSTAF-TREF is a completely automated apparatus for the
analysis of the Chemical Composition Distribution in
Polyolefins by CRYSTAF (Crystallization Analysis Fractionation)
and TREF (Temperature Rising Elution Fractionation)
techniques, providing a broad structural data base to improve
catalyst knowhow and allowing new resins design.
· Analytical Services:
Polymer Char offers worldwide polyolefin characterization,
fractionation and consulting services, addressed to the
petrochemical, academia and research industries.
FAST AND FURIOUS
phone: +1-(413) 835-0265
www.pss-polymer.com | [email protected]
Driving GPC/SEC forward
GPC/SEC Solutions – Products – Expert Support PSS - Acknowledged Global Leader in GPC/SEC Analysis
GPC/SEC is our only passion! We at PSS are dedicated to the advancement of the technique of macromolecular liquid chromatography. We design products that of-fer users powerful but cost effective solutions for the analysis of both simple and complex macromolecular materials, backed by the support of the largest group of GPC/SEC experts in the world. Working at the leading edge of material science research, we work constantly with our customers to ensure that our products can be used, with confidence, in both routine QC and R&D analysis.
PSS offers the widest portfolio of products including molecular weight refer-ence materials and a huge array of columns and application optimized GPC/SEC stationary phases. Our state of the art instruments, software and turn-key solu-tions for GPC/SEC range from single concentration detectors, to multi-detection with light scattering, and viscometry through to hyphenated techniques such as GPC/SEC coupled to mass spectrometers and NMR. Our systems are designed to be fully compliant for the pharmaceutical industry.
Call us and discuss your application challenges with our group of dedicated and enthusiastic specialists.
For all Organic Eluents
• For all Aqueous Eluents
• For High and Low Molecular Weight
Synthetic and Bio-Polymers
• From Micro GPC/SEC up to Preparative Scale
• HighSpeed Columns for fast Analysis
GPC/SEC Instruments• Complete Systems and Components
• Light Scattering Detectors
• Viscosity Detectors
• dn/dc Instrumentation
GPC/SEC Schools and Support • Full Services from Installation to Validation,
Operation, and Repair
• GPC/SEC and Software Training Schools
• GPC/SEC In-house Training
• User Meetings
• NetCommunity with Application and
Publication Downloads
Supplies and Services for Comprehensive Characterization of Natural and Synthetic Macromolecules
Reference Polymer Standards• GPC/SEC Standards and Kits
• Certified Reference Materials
• MALDI Kits
• Viscosity & Light Scattering Validation Kits
• ReadyCal Kits
• Deuterated Polymers
• Tailor made Polymers and Copolymers
Software WinGPC UniChrom MACROMOLECULAR
CHROMATOGRAPHy DATA SySTEM
• Light Scattering Module for LALLS, RALLS,
TALLS, MALLS
• Viscosity Module
• Copolymer Module
• End-group Analysis Module
• 2-dimensional Chromatography Module
• Heparin Module
• LAN/Server Solutions
• Compliance Pack
PoroCheck SOFTWARE FOR PORESIzE ANALySIS
AND INVERSE GPC/SEC
Analytical Services• Molar Mass Determination
• Branching/Structure Information
• Method Developement and Transfer
• Complete Product Deformulation
• Consulting
56 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2011 www.chromatographyonline.com
Company DescriptionWyatt Technology Corp. (WTC) is the world’s largest company dedicated to light-scattering detectors for LC. Dr. Philip J. Wyatt, the president and founder of the company, was the developer of the first commercial multiangle light-scattering instruments more than 40 years ago. Dr. Wyatt is one of the world’s leading authorities in the light-scattering field, holds more than 20 pat-ents pertaining to light scattering, and is the author of four texts and over 50 publications. The company’s light-scattering detec-tors have been sold in more than 50 countries, making them the most popular light-scattering instruments available. Wyatt Technology’s extensive applications laboratory coupled with its full-time staff (including 17 PhD scientists) means our custom-ers receive deep technical expertise and support.
Chief Chromatographic Techniques Supported ⦁ HPLC ⦁ GPC/SEC/GFC ⦁ RPC ⦁ Field flow fractionation
Markets ServedWyatt provides its products to a wide range of markets includ-ing, but not limited to, companies involved with biotechnology, pharmaceutical development, chemical, petrochemical, and academic research laboratories. In addition, WTC provides its products to the United States government and has active cus-tomers in the Food and Drug Administration, National Institutes of Health, and the U.S. Army, Navy, and Air Force. Abroad, WTC’s distributor network supplies the world with products, support, and training, be it in Asia, Europe, Africa, or South America.
Major Products/ServicesWTC’s family of instruments includes: ⦁ DAWN HELEOS: An 18-angle light-scat-
tering instrument that can be used at ambient, elevated, and below ambient temperatures.
⦁ MiniDAWN: A three-angle instrument that is ideal for proteins and peptides and molar masses below 1 million Da.
⦁ Eclipse system: For separation of mac-romolecules and nano particles in solution.
⦁ Optilab TrEX: The most advanced RI detector in the world with 256 times the detection power and 50 times the dynamic range of any other RI detec-tor. The TrEX can be operated below or above ambient temperature and deter-mine dn/dc at the same wavelength of light as the light-scattering instrument.
⦁ WyattQELS: A quasi-elastic (dynamic) light-scattering instrument that can be interfaced to the DAWN or the mini-DAWN Tristar in order to determine particle sizes as small as 1 nm.
⦁ ViscoStar viscometer: A state-of-the-art intrinsic viscosity detector that can be operated above or below ambient tem-perature with its precise Peltier ther-mostatic controls. The ViscoStar also includes software for determining the Mark-Houwink coefficients for polymers and biopolymers.
⦁ WTC Protein Columns: A family of new silica based columns specifically designed for SEC/MALS protein applica-tions. These columns retain all the im-portant features of a first-class SEC col-umn for protein separations. They are made of the highest quality silica with well-controlled pore sizes and highly reproducible surface chemistry.
FacilitiesWTC maintains more than 30,000 ft2 of modern electronics, optical prototype, machine shop, and laboratory facilities in Santa Barbara, California.
Wyatt Technology Corp.6300 Hollister Ave.
Santa Barbara, CA 93117
T e l e p h o n e
(805) 681-9009
F a x
(805) 681-0123
e - m a i l
[email protected] e b s i T e
www.wyatt.com
n u m b e r o F e m p l o y e e s
85
y e a r F o u n d e d
1982
Wyatt Technology Corp.