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CBD
OBAT ANTIVIRUS
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OBAT ANTIVIRUS
Non Retroviral Anti herpes
Anti hepatitis
Anti influenza
Antivirus lain
Retroviral
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REPI!ASI VIRUS DNA
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A"EN ANTI #ERPES VIRUS
A$%$lovir
Vala$%$lovir
&a'$i$lovir ( Pen$i$lovir
Trifluri)ine
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ACYCLOVIR
O*at oral %an+ perta'a 'un$ul untu, infe,si #erpes si'ple- viru
vari$ella0zoster virus .V1V/2
Mekanisme Kerja: 1at a,tif asi,lovir .triphosphate/ se
'en+ha'*at poli'erase DNA virus3 )an 'e'ili,i efe, 'ini'a
host2 Sehin++a o*at ini 'e'ili,i margin of safetytin++i2
Triphosphate asi,lovir
.4/ 5en+ha'*at DNA poli'erasrepli,asi virus3 )an .6/ *er+a*un+ )en+an DNA )an '
ter'inasi rantai %an+ pre'atur
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&AR5A!O!INETI!
Bioavaila*ilitas Oral7 4809:; E,s,resi7
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INDI!ASI
Terapi untu, infe,si #SV04 ( #SV06 pri'er>re,uren3 infe,si V1V
.se$ara in vitro asi,lovir )apat 'en+ha'*at Epstein Barr virus ($%to'e+alovirus/
Terapi infe,si #SV pa)a pasien i''uno$o'pro'ise)
Pen$e+ahan infe,si #SV04 ( #SV06 perinatal3 )an terapi infe,si #
neonatus
Terapi infe,si ensefalitis #SV04 Terapi infe,si V1V untu, 'enurun,an risi,o P#N
Profila,sis setelah paparan )an terapi infe,si Herpes simiae .pa)a
'on%et/
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Cara pe'*erian7
A$%$lovir IV'erupa,an DOC untu, terapi infe,si serius %an+
)ise*a*,an oleh virus herpes si'ple- atau virus vari$ella0zoster
A$%$lovir POA$%$lovir topi,al .,uran+ efe,tif )i*an)in+,an A$%$lovir PO/2
Terapi untu, pen%a,it #SV harus se+era2 Untu, pen%a,it re,ure
)apat 'ulai )i*eri,an saat sta)iu' pro)or'al2
Terapi untu, vari$ella palin+ efe,tif )i'ulai )ala' 6? @a' perta'
'un$uln%a vesi,el2
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E&E! SA5PIN"
Renal .insi)ensi ES 8;/
!ristalisasi pa)a tu*ulus renalis %an+'en%e*a*,an o*stru,si
nephropath%
Interstitial nephritis
Central nervous s%ste' .insi)ensi ES
4;/ ethar+%
Tre'ors
Confusion
Seizures
5is$ellaneous
Phle*itis ith intravena)'inistration
Rash
Re$all )er'atitis
&i-e) )ru+ eruption Elevate) liver fun$tio
Neutropenia
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VALACYCLOVIR
5E!ANIS5E !ERA7 Sa'a )en+an asi,lovir
&AR5A!O!INETI!7 Vala$%$lovir 'erupa,an l-valine ester )ari a$%$lovir3
)en+an *ioavai*ilitas oral le*ih tin++i )ari a$%$lovir2
In)i,asi7
Terapi infe,si pri'er atau re,uren #SV
5ensupresi infe,si #SV +enital re,uren %an+ *erulan+
Terapi herpes zoster
.se$ara in vitro valasi,lovir )apat 'en+ha'*at Epstein
Barr virus3 na'un ti)a, 'en+ha'*at EBV )i )arah/
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E&E! SA5PIN"Selain efe, sa'pin+ %an+ ter)apat pa)a asi,
thrombotic thrombocytopenic purpura / hemolytic ur
syndrome .TTP>#US/ )apat ter@a)i pa)a pasien )en+an
)an i'uno)efisiensi %an+ 'en)apat valasi,lovir )osis t
.hari/2
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Famciclovir & Penciclovir
5e,anis'e ,er@a7 sa'a )en+an asi,lovir
&ar'a,o,ineti,7
&a'$i$lovir +uanine 'erupa,anprodrug)ari pen$i$lov
A*sor*si &a'$i$lovir le*ih *ai, )ari pen$i$lovir2
Bioavaila*ilitas fa'$i$lovir oral7 ;
INDI!ASI7
Sa'a )en+an van$%$lovir2
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E&E! SA5PIN"7
#ea)a$he Nausea
Diarrhea
Dizziness
Pen++unaan harus hati0hati pa)a $reatinine $learan$e = :;2
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RIF!RI"I#$
5E!ANIS5E !ERA Trifluri)ine triphosphate 'en+inhi*isi poli'erasi DNA
sel host3 'es,ipun tin+,at inhi*isi pa)a sel host le*ih s
!arena to,sisitas ini3 trifluri)ine han%a )i+una,an pa)
topi,al )ala' *entu, $airan optal'i,us 4;2
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In)i,asi7 Terapi #SV $on@un$tivitis3 #SV ,eratitis3
Treat'ent of re$urrent #SV ,eratitis
E&E! SA5PIN" 5il) *urnin+
Palpe*ral e)e'a
Pun$tate ,eratopath%
Stro'al e)e'a
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ain0lain
"an$i$lovir
se$ara in vitro3 le*ih a,tif terha)ap $%to'e+alovirus .C5V/ )i*an)in+,an A$% In)i,asi7 untu, retinitis %an+ )ise*a*,an $%to'e+alovirus pa)a in)ivi)u %an+
immunocompromised3 ter'asu, AIDS2
&os$arnet
In)i,asi7
Terapi infe,si C5V
Terapi acyclovir-resistant HSV infections Terapiganciclovir-resistant CMV infections
Efe, Sa'pin+7 Renal .9:;/
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Ci)ovovir
INDI!ASI
C5V retinitis in AIDS
Terapi infe,si #SV ( C5V %+ resisten
Efe,tif 'elaan virus po- .variola3 'on,e%po-3 'ollus$u' $onta+iosu'/ Pen++unaan se)iaan topi,al pa)a lesi infe,si papillo'avirus3 !aposi sar$o'
#SV
E&E! SA5PIN"
Renal .8;/
InterferonInterferon )i+una,an untu, pen+o*atan pen%a,it virus neoplas'a .'ela
hepatitis B3 $on)%lo'a a$u'inata .intralesi/2
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TERI5A !ASI#