Scribd Obat Antivirus

7/25/2019 Scribd Obat Antivirus

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CBD

OBAT ANTIVIRUS


2/22

OBAT ANTIVIRUS

Non Retroviral Anti herpes

Anti hepatitis

Anti influenza

Antivirus lain

Retroviral


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REPI!ASI VIRUS DNA


4/22

A"EN ANTI #ERPES VIRUS

A$%$lovir

Vala$%$lovir

&a'$i$lovir ( Pen$i$lovir

Trifluri)ine


5/22

ACYCLOVIR

O*at oral %an+ perta'a 'un$ul untu, infe,si #erpes si'ple- viru

vari$ella0zoster virus .V1V/2

Mekanisme Kerja: 1at a,tif asi,lovir .triphosphate/ se

'en+ha'*at poli'erase DNA virus3 )an 'e'ili,i efe, 'ini'a

host2 Sehin++a o*at ini 'e'ili,i margin of safetytin++i2

Triphosphate asi,lovir

.4/ 5en+ha'*at DNA poli'erasrepli,asi virus3 )an .6/ *er+a*un+ )en+an DNA )an '

ter'inasi rantai %an+ pre'atur


6/22

&AR5A!O!INETI!

Bioavaila*ilitas Oral7 4809:; E,s,resi7


7/22

INDI!ASI

Terapi untu, infe,si #SV04 ( #SV06 pri'er>re,uren3 infe,si V1V

.se$ara in vitro asi,lovir )apat 'en+ha'*at Epstein Barr virus ($%to'e+alovirus/

Terapi infe,si #SV pa)a pasien i''uno$o'pro'ise)

Pen$e+ahan infe,si #SV04 ( #SV06 perinatal3 )an terapi infe,si #

neonatus

Terapi infe,si ensefalitis #SV04 Terapi infe,si V1V untu, 'enurun,an risi,o P#N

Profila,sis setelah paparan )an terapi infe,si Herpes simiae .pa)a

'on%et/


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Cara pe'*erian7

A$%$lovir IV'erupa,an DOC untu, terapi infe,si serius %an+

)ise*a*,an oleh virus herpes si'ple- atau virus vari$ella0zoster

A$%$lovir POA$%$lovir topi,al .,uran+ efe,tif )i*an)in+,an A$%$lovir PO/2

Terapi untu, pen%a,it #SV harus se+era2 Untu, pen%a,it re,ure

)apat 'ulai )i*eri,an saat sta)iu' pro)or'al2

Terapi untu, vari$ella palin+ efe,tif )i'ulai )ala' 6? @a' perta'

'un$uln%a vesi,el2


9/22

E&E! SA5PIN"

Renal .insi)ensi ES 8;/

!ristalisasi pa)a tu*ulus renalis %an+'en%e*a*,an o*stru,si

nephropath%

Interstitial nephritis

Central nervous s%ste' .insi)ensi ES

4;/ ethar+%

Tre'ors

Confusion

Seizures

5is$ellaneous

Phle*itis ith intravena)'inistration

Rash

Re$all )er'atitis

&i-e) )ru+ eruption Elevate) liver fun$tio

Neutropenia


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11/22

VALACYCLOVIR

5E!ANIS5E !ERA7 Sa'a )en+an asi,lovir

&AR5A!O!INETI!7 Vala$%$lovir 'erupa,an l-valine ester )ari a$%$lovir3

)en+an *ioavai*ilitas oral le*ih tin++i )ari a$%$lovir2

In)i,asi7

Terapi infe,si pri'er atau re,uren #SV

5ensupresi infe,si #SV +enital re,uren %an+ *erulan+

Terapi herpes zoster

.se$ara in vitro valasi,lovir )apat 'en+ha'*at Epstein

Barr virus3 na'un ti)a, 'en+ha'*at EBV )i )arah/


12/22


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E&E! SA5PIN"Selain efe, sa'pin+ %an+ ter)apat pa)a asi,

thrombotic thrombocytopenic purpura / hemolytic ur

syndrome .TTP>#US/ )apat ter@a)i pa)a pasien )en+an

)an i'uno)efisiensi %an+ 'en)apat valasi,lovir )osis t

.hari/2


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Famciclovir & Penciclovir

5e,anis'e ,er@a7 sa'a )en+an asi,lovir

&ar'a,o,ineti,7

&a'$i$lovir +uanine 'erupa,anprodrug)ari pen$i$lov

A*sor*si &a'$i$lovir le*ih *ai, )ari pen$i$lovir2

Bioavaila*ilitas fa'$i$lovir oral7 ;

INDI!ASI7

Sa'a )en+an van$%$lovir2


15/22

E&E! SA5PIN"7

#ea)a$he Nausea

Diarrhea

Dizziness

Pen++unaan harus hati0hati pa)a $reatinine $learan$e = :;2


16/22


17/22

RIF!RI"I#$

5E!ANIS5E !ERA Trifluri)ine triphosphate 'en+inhi*isi poli'erasi DNA

sel host3 'es,ipun tin+,at inhi*isi pa)a sel host le*ih s

!arena to,sisitas ini3 trifluri)ine han%a )i+una,an pa)

topi,al )ala' *entu, $airan optal'i,us 4;2


18/22

In)i,asi7 Terapi #SV $on@un$tivitis3 #SV ,eratitis3

Treat'ent of re$urrent #SV ,eratitis

E&E! SA5PIN" 5il) *urnin+

Palpe*ral e)e'a

Pun$tate ,eratopath%

Stro'al e)e'a


19/22


20/22

ain0lain

"an$i$lovir

se$ara in vitro3 le*ih a,tif terha)ap $%to'e+alovirus .C5V/ )i*an)in+,an A$% In)i,asi7 untu, retinitis %an+ )ise*a*,an $%to'e+alovirus pa)a in)ivi)u %an+

immunocompromised3 ter'asu, AIDS2

&os$arnet

In)i,asi7

Terapi infe,si C5V

Terapi acyclovir-resistant HSV infections Terapiganciclovir-resistant CMV infections

Efe, Sa'pin+7 Renal .9:;/


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Ci)ovovir

INDI!ASI

C5V retinitis in AIDS

Terapi infe,si #SV ( C5V %+ resisten

Efe,tif 'elaan virus po- .variola3 'on,e%po-3 'ollus$u' $onta+iosu'/ Pen++unaan se)iaan topi,al pa)a lesi infe,si papillo'avirus3 !aposi sar$o'

#SV

E&E! SA5PIN"

Renal .8;/

InterferonInterferon )i+una,an untu, pen+o*atan pen%a,it virus neoplas'a .'ela

hepatitis B3 $on)%lo'a a$u'inata .intralesi/2


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TERI5A !ASI#

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