Name : Lie Khie Chen
Birth : Jakarta
Graduates
MD : FMUI 1994
Internist : FMUI 2003
Consultant : FMUI 2006
PhD : FMUI 2014
Occupation
Internal Medicine Department
Tropical Medicine and Infectious Diseases Division
Interest
Sepsis
Antimicrobial Treatment
Antimicrobial Resistance
Fungal Infection
HIV and opportunistic infections
Curriculum Vitae
Workshop PIN PAPDI 2014
Diagnosis dan Penatalaksanaan
Sepsis
Khie Chen
Tropical Medicine and Infectious Disease Division
Internal Medicine Department
Medical Faculty University of Indonesia
SepsisClinical syndrome
Host responseto infection
Systemicprocess
Multi organ system affected
Konsep Disfungsi dan Gagal Organ pada Sepsis
The Major Networks of
the Host Response
Following Microbial
Challenge by PAMPs
(Pathogen Associated
Molecular Patterns) or
Tissue Injury by DAMPs
(Danger Associated
Molecular Patterns)
Definisi Sepsis
SCCM/ESICM/ACCP/ATS/SIS 2001
Infeksi : terdokumentasiataususpek
Parameter umum:Suhu(temperatur rectal/ core>38,3oC)
Hipotermia (temperatur rektal/core90x/ menit atau
>2SD diatasnilai normal menurut umur
Takipnu >30x/ menit
Perubahanstatus mental/kesadaran
Edema ataubalancairan positif (>20ml/kg/24jam)
Hiperglikemia (glukosaplasma>110 mg/dl) tanpadiabetes
Parameter inflamasi: Lekositosis(Lekosit>12.000/ul)
Lekopenia(Lekosit10%
PeningkatanCRP > 2SD nilainormal
PeningkatanPCT > 2SD nilainormal
Parameter hemodinamik:Hipotensiarterial
(tekanansistolik70%
Indekskardiak>3.5 l/menit/m2
Levy MM, Fink MF, Marshall JC, et al. 2001
SCCM/ESICM/ACCP/ATS/SIS international sepsis definition
confrences. Intensive Care Med 2003; 29: 530-8.
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