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INTISARI
FIFIANA, L, I., FORMULASI KAPTOPRIL DALAM SEDIAAN TABLET
LEPAS LAMBAT DENGAN MATRIKS KOMBINASI HIDROKSIPROPIL
METILSELULOSA DAN METIL SELULOSA, SKRIPSI, FAKULTAS
FARMASI, UNIVERSITAS SETIA BUDI, SURAKARTA.
Kaptopril adalah obat hipertensi yang memiliki waktu paruh 2-3 jam.Pemberian obat berulang dinilai tidak praktis, karena itu kaptopril diformulasikan
dalam bentuk sediaan tablet lepas lambat menggunakan matriks HPMC dan Metil
selulosa. Tujuan dari penelitian ini untuk mengetahui pengaruh kombinasi matriks
HPMC dan Metil selulosa dalam sediaan tablet lepas lambat kaptopril terhadap
sifat fisik dan kecepatan pelepasan obat yang memenuhi persyaratan.
Tablet lepas lambat kaptopril dibuat dalam 5 formula berdasarkan variasi
kadar : 100%HPMC : 0% Metil selulosa (FI), 75%HPMC : 25%Metil selulosa
(FII), 75%HPMC : 25% Metil selulosa (FIII), 0%HPMC :100%metil selulosa
(FIV) dan kontrol negatif (FV). Tablet dibuat dengan metode granulasi basah,
granul yang diperoleh diayak dengan ukuran 16/18 mesh. Granul yang diperoleh
diuji kualitas meliputi waktu alir dan sudut diam. Granul dicetak menjadi tablet
menggunakan mesin dengan tekanan maksimal. Tablet diuji kualitas mutu fisik
meliputi keseragaman bobot, kekerasan, kerapuhan tablet dan disolusi. Uji
disolusi dilakukan selama 8 jam dalam medium HCL 0,01 N menggunakan alat
tipe dayung dengan kecepatan 75rpm. Data dianalisis secara statistik dengananova satu jalan, LSD menggunakan SPSS 12.0 for windows dengan taraf
kepercayaan 95 %.
Hasil penelitian menunjukkan bahwa Penambahan HPMC mempercepat
waktu alir, memperkecil sudut diam granul dan kekerasan tablet. Hasil uji disolusi
menunjukkan bahwa pola pelepasan kaptopril dari tablet lepas lambat mengikuti
kinetika orde nol. Mekanisme pelepasan kaptopril pada formula I-IV mengikuti
mekanisme transport anomalous diffusionyaitu kombinasi erosi dan difusi dimana
mekanisme difusi lebih dominan, sedangkan pada formula V mengikuti
mekanisme difusi fick. Kecepatan pelepasan kaptopril : 0,0627mg/menit (FI);
0,0694mg/menit (FII); 0,0716 mg/menit (FIII); 0,0686mg/menit FIV);
0,0502mg/menit (FV).
Kata kunci: kaptopril, metil selulosa, HPMC
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ABSTRACT
FIFIANA, L, I.,CAPTOPRIL FORMULATION IN SUSTAINED RELEASE
TABLET BY COMBINATION MATRIX OF HYDROXYPROPYL
METHYL CELLULOSE AND METHYL CELLULOSE, THESIS,
FACULTY OF PHARMACY, SETIA BUDI UNIVERSITY, SURAKARTA.
Captopril is hypertensive drug which half life 2-3 hours. Repeated drug
administration considered impractical, because captopril formulated in a
preparation of sustained release tablet using HPMC and methyl cellulose matrix.
The purpose of this study was to findnot the effect of combinated HPMC and
methyl cellulose matrix in preparation of sustained release tablet of captopril to
the physical properties and release rate that meets the requirements.
Sustained release tablet of captopril was made in 5 formula based on
variations in levels : 100%HPMC : 0% methyl cellusosa (FI), 75%HPMC : 25%
methyl cellusosa (FII), 75%HPMC : 25% methyl cellusosa (FIII), 0%HPMC
:100%methyl cellusosa (FIV) and negative control(FV). Tablets was made by wet
granulation method, granules which obtained sieved by 16/18 mesh. The granules
which obtained teste in quality include flow rate and angle of repose. The granules
was molded into tablets using machine with a maximum pressure. Tablet was
tested for the physical quality included weight uniformity, hardness, friability and
dissolution. Dissolution testing conducted for 8 hour in 0,01 N HCL medium
using a paddle type device by speed of 75 rpm. Data were statistically analyzed byone way ANOVA, LSD using SPSS 12.0 for windows with 95% confidence.
The results showed that the addition of HPMC the flow rate, minimize the
angle of repose of granules and tablet hardness. The results of dissolution showed
that pattern of captopril release from sustained release tablet follows zero order
kinetic. Mechanism of captopril release on the formula I-IV follows transport
mechanism of Anomalous diffusion i.e combination of erosion and diffusion
wheres the diffusion mechanism was dominant, while in the formula V follows
the fick diffusion mechanism. Release rate of captopril : 0,0627mg/min (FI);
0,0694mg/min (FII); 0,0716 mg/min (FIII); 0,0686mg/min(FIV);
0,0502mg/min(FV).
Keywords : sustained release, captopril, methyl cellulose, HPMC
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