PROF. PRAVAT KUMAR MANDAL Office : Room no. 04 1st ...

1. Name (In Block Letters)

2. Postal address:

: PROF. PRAVAT KUMAR MANDAL

Office

: Room no. 041st Floor, National Neuroimaging Facility,National Brain Research Center,

Manesar : 122052 : [email protected]:

S.No. Degree Board/University DivisionYear

of passing

Subjects

1. Secondary West Bengal Board of Secondary Education

1st Division 1980 Mathematics, Physical Science,Biology, History, Geography,

English, Bengali2. Higher

SecondaryWest Bengal Board of

Higher Secondary Education1st Division 1982 Mathematics, Physics,

Chemistry, Biology3. B. Sc Burdwan University 2nd Division 1985 Chemistry (Hons), Mathematics,

Physics4. M. Sc Burdwan University 1st Division 1988 Physical Chemistry5. Ph. D Indian Institute of

Technology, Madras1995 Thesis Title: Exchange

interactions in some bimetallic systems: experimental and

theoretical approach

Dr. Pravat Mandal, Ph.D from IIT Madras and worked as Assistant professor in Psychiatry in The University of Pittsburgh Medical school, and Associate Prof. (Adj) Johns Hopkins Radiology and presently, Professor at NBRC and Honorary professor at Florey Institute of neuroscience, Melbourne (Australia) . Leader in Alzheimer disease clinical research. Played a seminal role for translational research in Alzheimer's disease. Dr. Mnadal served as Officiating Director at NBRC and published many research papers with high citations (H-Index 28 out of 65 papers in International Journals.) His research is supported by National and International grant including US air force.

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11. Experience (from current to oldest):

S. No. From To Position held Scale of Pay

Name of Organization

1. May2020 Till Date Officiating

Registrar NA

National Brain Research Centre(NBRC)

Manesar – 122052, India2. September

2018TillDate

Scientist (VII)Senior Prof. GP 10000

worked as Officiating Director (when Director,

NBRC is out of town)NA

3. March 2013 September2018

Scientist (VI)Professor GP 8900

4. July 2008 March2013

Scientist (V)Additional Prof. GP 8700

5. August 2016 Till Date HonoraryProfessor NA

Florey Institute of Neuroscience and Mental Health, Melbourne,

Australia

6. February2011 May 2016 Adjunct Associate Professor NA

Dept. of Radiology, Johns Hopkins School of Medicine,

Maryland, USA

7. March 2004 June 2008 AssistantProfessor NA

Dept. of Psychiatry,University of Pittsburgh, School of

Medicine, Pennsylvania, USA

8. June 2002 March2004

Research Instructor(Faculty) NA

Dept. of Psychiatry,University of Pittsburgh, School of


9. December2000

June2002

Research Instructor(Faculty) NA

Dept. of Anesthesia,University of Pittsburgh, School of


10. February1999

December2000

ResearchScientist NA

Dept. of Structural Chemistry, Johannes Kepler University, Linz

Austria

11. December1997

December1998

ResearchAssociate NA

Dept. of Biochemistry,Hong Kong University of Science and Technology, Hong Kong

12. October1996

December1997

Post-doctoral Fellow NA

Prof. G.N. LaMar’s Lab,Dept. of Chemistry, University of

California, Davis, USA

13. July1995

September1996

Projectofficer NA

Regional Sophisticated Instrumentation Centre, IIT India,

Madras, India

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12. Professional training undergone, if any, and details thereof:Training Program Organized By Details

Medical Imaging

Indian Institute of Technology (IIT), Madras

NMR pulse sequence development training at Dept. of Chemistry, IIT, Madras during PhD.

Valence Bond Theoretical

Computation

Indian Institute of Science (IISC), Bangalore

Training for supercomputing at Solid State and Structural Chemistry Unit at IISc, Bangalore, during Ph. D

Clinical Residency Program

Alzheimer’s Disease Research Centre, University of

Pittsburgh Medical School,USA

Trained for conducting clinical research with patients suffering from neurodegenerative disorders and helped in gaining an experience tohandle patients and provided a comprehensive knowledge of the patient recruitment process,neuropsychological testing and analysing behavioural data.

Special training in global

research centrein brain imaging

Philips Corporation at the Philips Global Innovation Centre, Bengaluru, India

This program provided an opportunity to implement novel technology in brain-related research at NBRC and succeeded in extractingsignificant information related to brain glutamate/ glutamine level.

13. Honors/ Awards/ Fellowship received: List Honors, Awards and Fellowships separately

i. Global Artificial Intelligence Award (Category: Lifetime Achievement Award) by AllIndia Council for Robotics & Automation, 2019.

ii. TATA INNOVATION Fellow, Department of Biotechnology, Govt of India.

14. Total Research / Academic experience (As an Independent Scientist):

A total twenty-three years and nine months (23+) of research as well as academic experience.

Twelve years of research as well as academic experience in the NeuroSpectroscopy andNeuroimaging (NINS) Laboratory at National Brain Research Centre (NBRC), Manesarfrom July 2008 to till date. In addition, five years and three months worked as an AdjunctAssociate Professor in the department of Radiology at Johns Hopkins School of Medicine,Maryland, USA from Feb 2011 to May 2016.Four years and 3 months of academic experience as an Assistant Professor in the departmentof Psychiatry at University of Pittsburgh, School of Medicine, Pennsylvania, USA from Mar2004 to June 2008.Twenty one months of research experience as a Research Instructor (Faculty) in thedepartment of Psychiatry from June 2002 to March 2004 at the University of Pittsburgh,School of Medicine, Pennsylvania, USA.

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Twenty one months of research experience as a Research Instructor (Faculty) in thedepartment of Anesthesia from Dec 2000 to June 2002 at the University of Pittsburgh, Schoolof Medicine, Pennsylvania, USA.Twenty one months of research experience as a Research Scientist in the department ofStructural Chemistry at Johannes Kepler University, Linz Austria from Feb 1999 to Dec2000.One years of research experience as Research Associate in the department of Biochemistryat Hong Kong University of Science and Technology, Hong Kong from Dec 1997 to Dec1998.Fifteen months of research experience as Post-doctoral Fellow in the department ofChemistry at University of California, Davis, USA from Oct 1996 to Dec 1997.

Please see the Annexure A for more details

15. Details of research work:a) Research pursued in various areas which includes the following:

Basic Science ResearchNMR Spectroscopy - Application of 1H and multinuclear (15N, 13C)NMR Spectroscopy inprotein 3D structure studies

Clinical Research/Memory PerformanceAlzheimer’s Disease (AD) - Investigating the role of relative levels of these two GSHconformations, the link between iron deposition and oxidative stress in the hippocampalformation in the brain of AD patients.Parkinson’s Disease (PD) - Investigating the link between oxidative stress, iron depositionand effect of neurodegeneration on neurotransmitter distribution in the substantia nigra(SN) region of PD patients.BRAHMA-The Indian Brain Template - BRAHMA set of T1w, T2w and FLAIR braintemplates have been constructed from a cohort of 113 healthy young participants andreleased along with a full set of tissue probability maps, brain segmentation priors and 23sets of atlas labels. Geriatric brain template is under construction.

Technology Oriented ResearchKALPANA - MRS data processing packageGAURI - Machine Learning and Pattern Recognition for neuroimaging-based diagnosisSTIM - fMRI paradigm design, presentation, and response collection systemBRAHMA - MRI template construction toolboxMDI - Multimodal neuroimaging data integrationNINS-STAT - Automated statistical analysis softwareANSH - Neuroimaging database management systemBHARAT - Big Data Analytics for NeuroimagingTranslational ResearchImpact of Glutathione (GSH) Supplementation in Mild Cognitive Impairment (MCI)Patients: A Randomized Control Trial

Please see the Annexure B for more details

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b) Research Funding from International Agencies (from current to oldest)

Sr. No. Title of the Project Funding Agency Role Status/

Duration

1.

Non-Invasive Imaging-Based Detection and Mapping of Brain Stress and its Correlations

with Cognitive Functions. Grant no.: FA2386-13-1-4051 AOARD 134051

Asian Office of Aerospace Research and Development (AOARD), Department of

Defence, US Air Force

Principle Investigator

Completed2013-2016

2.

Characterization of the molecular interactions of anaesthetics with the beta

amyloid.Grant No.: II/21022/23(27)/2010-FCRA-

III(P).

PRIN Grant, Italian Ministry for Education, University and Research


Completed2006-2013

3. -Synuclein.https://www.adrc.pitt.edu/about/research-

projects/past-projects/pilot-projects/

Alzheimer’s DiseaseResearch Centre Pilot Grant, University of

Pittsburgh Medical School (part of NIH major Centre

grant)


Completed2004-2006

4.

-synuclein interactions: Molecular Mechanisms in overlapping Pathology of Alzheimer’s and Parkinson’s in Dementia

with Lewy Body Disease.

American Parkinson Disease Association (USA)


Completed2005-2006

5.NMR studies of Ganglioside- -40)

interactions in Alzheimer’s Disease Research.

American Health Assistance Foundation

(USA)


Completed2003-2006

c) Research Funding from Indian Agencies (from current to oldest during tenure at NBRC)

Sr. No. Title of the Project Funding Agency Role Status/

Duration

1.

Artificial Intelligence for Early Predictive Diagnosis of Alzheimer’s disease using

Multimodal Imaging Data.Grant no: 4(5)/2019-ITEA

Ministry of Electronics and Information Technology,

Govt. of India.


In progress2019-2022

2.Novel Imaging Diagnostics for Alzheimer’s

Disease.Grant no: BT/Indo-Aus/10/31/2016

Indo-Australia Biotechnology Fund


Indian Counterpart


3.

Unravelling the causes of stroke and cognitive decline in general population: A cross-cultural

perspective. Grant no: BT/IN/Netherlands/03/KP/2012

DBT-Netherlands Co-Investigator


4. Development of Indian Brain Template.Grant no: SR/CSRI/229/2015

Dept. of Science & Technology,

Govt. of India



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5.

Non-Invasive Imaging Technology Development to Aid Differential Diagnosis of Alzheimer’s, Dementia with Lewy Body and Parkinson’s Disease from Brain Glutathione

Quantitation and pH Mapping.Grant no.: BT/HRD/35/01/05/2014

DBT- TATA Innovation Fellowship


(TATA Innovation

Fellow)

Completed2014-2019

6.

National Program for Perception Engineering phase II- Technology Development for early

diagnosis of Alzheimer’s disease from Visuospatial perception profile using

functional magnetic resonance imaging. Grant no: DeitY/R&D/TDC/13(5)/2013


Govt. of India.


Completed2013-2018

7.

Pulse sequence (in vivo) and processing scheme development for anaesthetics and

Amyloid-19F-MRS.

Grant no: BT/PR5386/MED/30/816/2012

Dept. of Biotechnology, Govt. of India


Completed2012-2014

8. Functional MRI and perception.Grant no: DIT/percept/PKM/2011


Govt. of India.


Completed2011-2012

9.The Understanding of Early Molecular Events

which initiate the Alzheimer’s Disease. Grant no.: BT/PR11953/MED/30/183/2009



Completed 2010- 2014

10.

Characterizing biomarkers of Alzheimer’s Disease: A longitudinal multimodal brain

imaging study.Grant no: BT/PR7361/MED/30/953/2009



Completed2009-2013

d) Editorial Responsibilities in International Journals (latest to oldest):

i. Regional Editor, Asia-Pacific Region, Journal of Alzheimer’s Disease, since January 2020ii. Associate Editor, Journal of Alzheimer’s Disease, 2013-2019

iii. Senior Editor, Journal of Alzheimer’s Disease, 2011-2013

Editorial Responsibilities in Spacial Issues of International Journals:

i. Research Topic Editor, Frontiers in Neurology, 2019ii. Guest Editor in Special Issue, American Journal of Neuroradiology, 2014

iii. Guest Editor in Special Issue, Journal of Alzheimer’s Disease, 2012iv. Guest Editor in Special Issue, Journal of Alzheimer’s Disease, 2010

Please see the Annexure C for more details

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16. Details of publications (a list of publications may be provided)

Publications:

Please see the Annexure D for more details

17. Details of patents granted/applied:Three patents have been filed.

Title International / National Patent Application No Funding Role Icon

KALPANA: Amethod for metabolite signal quantitation for Magnetic Resonance

Spectroscopy data

PCT/IB2016/054978 (submitted for USA, Europe and home country-

India)/201611001944, 19 Jan 2016

Ministry of Electronics

and Information Technology (MEITY)

Principal Inventor

GAURI: An analytical and

predictive tool using metabolic pattern

learning

201911019667, 17 May 2019 (USA, Europe and home country- India)



Principal Inventor

Synchronized Timing Integrated Module

(STIM): A comprehensive

Functional Magnetic Resonance Imaging

Firmware

Patent application is under review for USA, Europe and home country- India

2020211021713, 23 May 2020



Principal Inventor

Please see the Annexure E for more details

Total no ofpublication in peerreviewed journals

Cumulativeh-index &

total citation

h-index

i-10index Area of Research

65https://scholar.google.co.in/citations?user=3iK6uS

MAAAAJ&hl=en

227(2284) 28 40

Clinical Neuroscience; Computational Neuroscience; Biophysical Chemistry; Alzheimer’s Disease; Parkinson’s Disease; Brain Templates; Anaesthetics and Neurodegeneration; Signal processing; Solid State Structural Chemistry

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18. Details of technology transferred/ developed:

Total four research modules and software have been developed.

NINS-STAT: A Quasi Automated Statistical Analysis SoftwareANSH: A Database management systemSUMEDHA: A GUI Toolbox for Quantitative Susceptibility Mapping Image Processing and ROIAssessmentBRAHMA: Development of Population Specific MRI Brain Template for India

Please see the Annexure F for more details

19. If the applicant is an OCI/NRI and is already working as a scientist in India, then please provide a copy ofclearance of Ministry of Home Affairs and Ministry of External Affairs as Annexure:

NA

20. Any other relevant information that you may like to furnish:

a) Social Outreach and Community ServiceWe extensively collaborate with the NGO- HelpAge India to organize Senior Citizenawareness programs about mental health and neurodegenerative diseases associated with oldage. In these sessions, onsite demonstrations of neuropsychological tests are provided topromote changes in their lifestyle for a healthy life. These awareness programs are organizedin senior citizen associations across Delhi NCR and Gurugram areas. In addition, a facility offree transport is also provided for senior citizens who want to participate voluntarily for a brainMRI and basic mental health check-up. In response to this, our Clinical neuropsychologistscreens them for basic mental fitness and provides their radiology reports free of cost. Theyare referred to our collaborating doctors, Dr Manjari Tripathi (MD, DM), AIIMS or Dr ArunGarg (MD, DM), Medanta, the Medicity if any kind of abnormalities is detected. So far, over600 senior citizens have already been assisted and the number continues to grow.

b) Chaired Sessions of International and National Conferences (latest to oldest):

i. Chair, Development of Novel Therapeutics of Alzheimer’s Disease: in vitro studiesSection, Society of Neuroscience San Diego, November 2016.

ii. Convener & Organizing Secretary, Advances in Neuroimaging and Applications inCognitive Disorders (ANACoD), May 2016, NBRC, India.

iii. Lead organizing member, International Brain Research Organization, November2010, NBRC, India.

iv. Co-Chair Alzheimer’s disease session, Biophysical Society Meeting, February 2006, SaltLake City, UT, USA.

v. Co-Chair of Alzheimer’s disease session, Biophysical Society Meeting, February 2004,Baltimore, MD, USA.

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c) Delivered Talks and Lectures (latest to oldest):

S. No. Title Organized By Role Date

1.Occupational Stress and Mental Health Issues among Uniformed

Personnel

Indian Institute of Public Health Gandhinagar

Plenary Speaker

October 2019

2.Brain Antioxidant Mapping and

its implications in Brain Disorder

IBRO Meeting Inaugural address Aug 2019

3. Molecular Medicine and Clinical Research

Translational Health Science andTechnology Institute (THSTI),

Faridabad

Keynote Address July 2019

4.Digital Diagnosis using

Neuroimaging Modalities: Tools and Applications

IIT Indore, MP, India Keynote Address

December 2017

5.Anesthetics simulating

molecular mechanism of Alzheimer’s disease

Anesthesia and Peri-Operative Care in the Seventh Age

Anesthesia Association Annual Scientific Meeting, Stratford-

upon-Avon, England, UK

Keynote Address May 2013

6.Brain pH mapping and what it

means to Radiologists

Dept. of Radiology, University of Kentucky School of Medicine,

Lexington, KY, USA

Oral Presentation June 2012

7. Brain pH using non-invasive Technology

Dept. of Radiology, University of California (UCLA), Los Angeles,

CA, USA

Oral Presentation

February 2012

8. Brain oxidative stress using MEGA PRESS sequence

Dept. of Psychiatry, University of Illinois, Chicago, IL, USA

Oral Presentation

November 2011

9. Anaesthetics and Impact on Cognition

International meeting on Cognition, Italian Ministry for

Education, University and Research, Barcelona, Spain


10. in vivo MRS spectroscopy on Alzheimer patients

International Conference on Physics Biology Interface, Saha

Institute of Nuclear Physics, India

Oral Presentation

December 2009

11. MRS spectroscopy and applications

Indian Institute of Technology International Conference on

Functional, Materials, Madras, India

Oral Presentation

November 2008

12. Pulse sequences in MRSDept. of Radiology, University of California (UCLA), Los Angeles,

CA, USA


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13. Ganglioside effect on Amyloid- Dept. of Neuroscience, University of California (UCSD),

San Diego, CA, USA


14. Oligomeric amyloid beta by NMR spectroscopy

International Conference on Alzheimer's Disease and Related

Disorders, Philadelphia, PA, USA

Oral Presentation May 2005

d) Membership of Professional Societies (latest to oldest):

Member, International Society for Magnetic Resonance in Medicine (April 2011-2013)Member, Society of Biological Psychiatry (May 2005 - Till date)Member, Society for Neuroscience (Jan 2003 - Till date)

e) Relevant Media Highlights

S. No. Title/Links Media Date

1. New tool to decode brain images of Indianshttps://www.natureasia.com/en/nindia/article/10.1038/nindia.2020.45

Nature India, Delhi

March2020

2.Brain Atlases

https://www.youtube.com/watch?v=N1Wgv7BTWSI&feature=youtu.be

DD National February2020

3.A Multi-center Study on Human Brain Glutathione Conformation using

Magnetic Resonance Spectroscopy https://www.medscape.com/viewarticle/906654

Medscape January2019

4.In Haryana, the Making of an Indian Brain TemplateFrontpage coverage of the Indian bran template The Hindu March

2018

5.Dr Mandal and his group research activities

https://www.youtube.com/watch?v=Mdm7phGyHtURajya Sabha

TVSeptember

2019

6.Potential therapy to halt Alzheimer’s Disease

https://www.natureasia.com/en/nindia/article/10.1038/nindia.2018.125Nature

India, DelhiSeptember

2018

7.Enhanced Stress Level in the brain and its impact on Brain

Connectivity and Alzheimer’s Diseasehttps://youtube.com/watch?v=zHerXVQ69EY

DD National October2015

8.

Antioxidant Help to Diagnose Alzheimer’s: Experts find proof https://timesofindia.indiatimes.com/home/science/Antioxidant-

helps-to-diagnose-Alzheimers-Experts-find-proof/articleshow/47409906.cms

Times of India

May 2015

9. Bigger Anesthetics Maybe Betterhttps://www.scientificamerican.com/article/bigger-anesthetics-may-be/

Scientific American,

MIND

April2007

10.Alzheimer’s alert over Anesthetics

https://www.newscientist.com/article/dn10392-alzheimers-alert-over-anaesthetics/?ignored=irrelevant#.UpRdHeJQilI

New Scientist, London

October2006

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f) Vision document

NBRC is a prestigious government institute comprising of multidisciplinary neuroscience research groupsto thoroughly investigate the brain. The establishment of NBRC was announced by the Minister of Science & Technology, Dr MGK Menon in 1997 and formally dedicated to the nation by the Hon'ble President of India, Dr A.P.J. Abdul Kalam in 2003. Systems Neuroscience, Computational Neuroscience and Neuroimaging in conjunction with Cellular & Molecular Neuroscience are three major and mandate divisions of NBRC, running with three primary objectives as detailed below:

Scientific investigation: To promote basic and clinical research to understand the function of healthy and diseased brain. Education: To generate trained human resources with capacity to carry out inter-disciplinary work in neuroscience. National-level facilitation: To promote neuroscience in India through networking among institutions across the country.

The well-equipped laboratories and a firm infrastructure with all facilities make NBRC an ideal place for conducting cutting edge research related to brain. Since the brain is the most complicated part of our body so only twelve research faculty and thirty staff members are not adequate to share the burden of quality research. Therefore, being a director, it would be on priority for me to heir prominent scientists from the different divisions of neuroscience for maintaining the domain specific expertise. Consequently, the number of PhD students would be raised that would further help in overall development of the institute. In addition, Training & Placement Cell would also be established to raise confidence in students for jobs by developing the skills for on-demand technologies. In this context, on campus placements drives would be conducted with an aim to place the maximum number of students in the top companies and organizations based on neuroscience, neurobiology, neuro physicians, and computational neuroscientists.

Moreover, the WHO prediction for the projected burden of brain related diseases in coming years for developing and developed countries as well motivated us to develop a big data system. In this context, we have a provision to build a common platforms for studying the human brain using big data (composed of imaging, biological data, neuroinformatic, brain simulation, and brain-tissue data) for creating a reliable and validated model that will run on supercomputers for high computational speed. The development of big data and high-performance computing to drive brain science will help in contributing the insights gained from the variety of brain-research projects. This will immensely help to place NBRC itself beside the other research communities working in the domain of neuroscience in the global league of mental health care. Besides that, we will build a unique Indian Database to cater research at national as well as international level where the data would be shared among researchers globally but with a prior mutual consent. It will further facilitate joint research program and grant proposal.

Place: NBRC, Manesar Signature of the candidateDate: 30th September 2020

(Dr. Pravat K Mandal)`

Annexure - A

(Research/Academic Experience)

Sr. No. Theme Timeline

Basic Science Research

a)i) Application of 1H and multinuclear (15N, 13C) NMR Spectroscopy

in protein 3D structure studies, drug-receptor interactions,Glutathione structure and temperature dependent conformation.

1997-Till date

Clinical Research

b)

i) -synuclein proteins.

ii) Application of non-invasive 1H spectroscopy characterization of brain tissue environment changes with respect to antioxidants (GSH), neurotransmitters (GABA and glutamate), brain pH (31PMRS) in neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s (PD). Functional characterization related to the decline of cognitive traits such as working memory and visuospatial perception in AD and amnestic Mild Cognitive Impairment (MCI). Association of brain iron susceptibility and cognitive profiles with neurodegeneration in AD and PD.

iii) Creation of a comprehensive set of high-resolution templates in different image contrasts, tissue segmentation maps and atlas labels, for both, young and elderly populations to be used in laboratory and clinical settings in the Indian sub-continent.

2004-Till date

Technology Development Oriented Research

c)

i) Along with clinical research, my lab also focuses on the development of software tools and packages that aid the Neuroimaging community in the translation of research from bench to bedside. The packages developed by the lab so-far include:

KALPANA (MRS data processing package)GAURI (Machine Learning and Pattern Recognition for neuroimaging-based diagnosis)STIM (fMRI paradigm design, presentation, and response collection system)BRAHMA (MRI template construction toolbox)MDI Toolbox (Multimodal neuroimaging data integration)NINS-STAT (Automated statistical analysis software)ANSH (Neuroimaging database management system)BHARAT (Big Data Analytics for Neuroimaging)

2008-Till date

(Details of Research Work)

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Annexure - B


Sr. No. Theme

a)

Basic Science Researchi. NMR Spectroscopy: Impact of microenvironment on protein structure; protein drug interaction, the

impact of anaesthetics and its impact on various receptors in the brain, impact of anaesthetics on the amyloid beta peptide. Impact of the Amyloid beta peptide with alpha synuclein and its inference in Dementia in Lewy body disease.

b)

Clinical Research/Memory Performance i. Alzheimer’s Disease:

Alzheimer's disease (AD) is a devastating neurodegenerative disease and is the most common cause of dementia. AD pathology is characterized by extracellular deposition of amyloid-accumulation of tau protein. In previous studies in our lab, using 1H MRS we have shown the regional distribution profiles of GSH in healthy and AD individuals. We have shown that hippocampus, frontal and cingulate cortical regions that are responsible for memory and higher cognitive functions respectively, show significant GSH depletion; and the cognitive decline in AD directly correlates directly to the GSH depletion in the left hippocampal formation. Using 31P MRS we have discovered that the pH of the left hippocampal f in AD shifts towards alkalinity.In healthy young participants, we have shown the existence of two- open and closed conformations of GSH. Presently, we are investigating the role of relative levels of these two GSH conformations, the link between iron deposition and oxidative stress in the hippocampal formation in the brain of AD patients.Additionally, we are investigating the relationship between the decline in cognitive features of working memory and visuospatial perception with the imbalance excitatory-inhibitory neurotransmitter distribution in the respective relevant brain areas of AD patients.Domain-specific behavioural and cognitive profiling is also performed for the participating cohorts by administering neuropsychological test batteries that screen for cognitive impairment and depressive symptoms, processing speed, attention, executive function, verbal, and spatial working memory. The outcomes of this profiling are then correlated with the functional and metabolic results obtained from imaging-based methods.

ii. Parkinson’s Disease: Parkinson's disease is a neurodegenerative disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination. The core pathology of PD affects the dopamine-producing

-synuclein aggregates. Presently, we are non-invasively investigating the link between oxidative stress, iron deposition and effect of neurodegeneration on neurotransmitter distribution in the SN region of PD patients when compared to age-matched controls. For correlating metabolic and cognitive profiles, extensive neuropsychological testing is performed to screen for cognitive impairment and depressive symptoms, motor movement impairments, impairment in visuospatial perception, executive function and attention.

iii. BRAHMA- The Indian Brain Template: Differences in brain morphology across population groups necessitate the creation of population-specific Magnetic Resonance Imaging (MRI) brain templates for interpretation of neuroimaging data. Variations in the neuroanatomy in a genetically heterogeneous population make the development of a population-specific brain template for the Indian subcontinent imperative. On these lines, BRAHMA set of T1w, T2w and FLAIR brain templates have been constructed from a cohort of 113 healthy young participants and released along with a full set of tissue probability maps, brain segmentation priors and 23 sets of atlas labels. Geriatric brain template is under construction.


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c)

Technology Oriented Research

i. KALPANA: It is an integrative platform for visualization, pre-processing and quantitation of MRS data acquired using single voxel, multi-voxel magnetic resonance spectroscopy for human studies.

ii. GAURI: It is a method and a system that uses adaptive pattern recognition and learning schemes for predictive single or differential diagnosis based on principles of pattern recognition and machine learning designed with magnetic resonance imaging modalities and neuropsychological batteries. Status: Under review for a national patent.

iii. Synchronized Timing Integration Module (STIM): It is a paradigm design, synchronized presentation, and response collection system for use in functional Magnetic Resonance Imaging (fMRI), to non-invasively image brain activity in cognitive processes, for clinical evaluation in cases of neurological diseases.Status: Under review for national patent grant.

iv. BRAHMA Toolbox: It is a platform for brain template construction involving image pre-processing, alignment to landmarks, brain extraction, image registration, image segmentation, image transformation and averaging, image labelling, and atlas construction.Status: Published and released for academic use.

v. MDI Toolbox: It is a scheme that spatially integrates ROI specific outcomes from different combinations of multimodal neuroimaging data (fMRI, MEG, MRS and QSM) and computes the overlapping common region between these. This toolbox has many potential applications in clinical neuroimaging.Status: Manuscript in progress

vi. NINS-STAT: It is an automated statistical analysis software package for researchers and clinicians that have been created keeping in mind people having no background or prior experience in statistical analysis.

vii. ANSH: It is the first Indian neuroimaging database management system that facilitates the management of subject data and can be scaled as per the requirements of a project or study.

viii. BHARAT: It is a Hadoop-based big data framework integrating non-invasive magnetic resonance imaging (MRI), MR spectroscopy (MRS) as well as neuropsychological test outcomes to identify early diagnostic biomarkers of AD.

d)

Translational Researchi. Title: “Impact of Glutathione (GSH) Supplementation in Mild Cognitive Impairment (MCI)

Patients: A Randomized Control Trial”Brief Description: Amnestic MCI is a prodromal stage of AD in which a person experiences problem with memory, decision making and planning, but capable in carrying out day-to-day routine activities. Although the exact cause triggering the AD pathology is still unknown, oxidative stress is considered a potential factor, and the role of the antioxidant GSH is an active area of research associated with memory loss in AD and MCI. In our previous work, we have reported a significant decrease in GSH in the hippocampus and frontal cortices (primarily associated with memory and planning) areas of MCI and AD patients. This decrease directly correlates with the cognitive profile obtained from neuropsychological testing. Based on previous animal and human studies, we hypothesize that GSH dietary supplementation for MCI patients will enhance brain GSH levels, subsequently reduce brain oxidative stress and improve cognitive profiles of MCI patients. Along with Dr Manjari Tripathi (MD, DM Neurology), we propose a novel prospective, single-centre, parallel-arm, double-blinded, placebo-controlled, phase III randomized trial using GSH as a dietary supplement for MCI patients, while monitoring brain GSH levels and cognitive profile using non-invasive MRS and neuropsychological testing respectively.Status: Waiting for necessary no objection certificate from DCGI.


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Annexure - C

(Editorial Responsibilities)

Impact demographics of the special issue:

Image Courtesy: frontiersin.org

i. Research Topic: Predictive Imageable Biomarkers for Neurodegenerative andNeurodevelopmental DiseasesJournal: Frontiers in Neurology, 2019Role: Research Topic Editor, along with Dr. Lars ErslandLink: https://www.frontiersin.org/research-topics/7132/predictive-imagable-biomarkers-for-neurodegenerative-and-neurodevelopmental-diseases#overview

ii. Issue Title: Metabolic Brain MappingJournal: American Journal of Neuroradiology, 2014, Volume 35, Issue 6Role: Guest EditorLink: http://www.ajnr.org/content/35/6_suppl

iii. Issue Title: Predictive Biomarkers for Alzheimer’s Disease using State-of-the-art Brain Imaging TechniquesJournal: Journal of Alzheimer’s Disease, 2012, Volume 31, Issue 3Role: Guest EditorLink: https://content.iospress.com/journals/journal-of-alzheimers-disease/31/s3

iv. Issue Title: Anesthetics and Alzheimer’s DiseaseJournal: Journal of Alzheimer’s Disease, 2010, Voume 22, Issue S3Role: Guest Editor, along with Dr. Vincenzo FodaleLink: https://content.iospress.com/journals/journal-of-alzheimers-disease/22/s3

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Publication

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Annexure - D

(List of Publications)

1) Mandal PK*, K Sandal, D Shukla, M. Tripathi, K Singh “ANSH: Multi-modalNeuroimaging Database Including Neurochemicals from Each Continent to Advance Alzheimer's Disease Research, Frontiers in Neuroinformatics, (in PRESS) (2020)

2) D Divya, M Kanu, M Ritwick, Mandal PK* “Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders” Neurochemical Research. 45:1461–1480 (2020)

3) Praful Pai, Mandal PK*, Khushboo Punjabi, Deepika Shukla, Anshika Goel “BRAHMA: Population Specific T1, T2, and FLAIR weighted Brain Templates and their impact in Structural and Functional Imaging Studies” Magnetic Resonance Imaging. 70 (5-21) (2020)

4) Mandal, PK*, D Shukla “KALPANA: Advanced Spectroscopic Signal Processing Platform for Improved Accuracy to Aid in Early Diagnosis of Brain Disorders in Clinical Setting” Journal of Alzheimer’s Disease. 75 (2) 397-402 (2020)

5) D Shukla, PK Mandal*, M Tripathi, G Vishwakarma, R Mishra, K Sandal “Quantitation of in vivo brain

” Human Brain Mapping. 41 (1), 194-217(2020)

6) Mandal PK*, L Ersland “Predictive Imagable Biomarkers for Neurodegenerative and Neurodevelopmental Diseases” Frontiers in Neurology. (2019)

7) Mandal PK*, Deepika Shukla, Manjari Tripathi, Lars Ersland, “Cognitive Improvement with Glutathione Supplement in Alzheimer's Disease: A Way Forward” Journal of Alzheimer’s Disease. vol. 68(2): 531-535 (2019)

8) A Sharma, Deepika Shukla, Tripti Goel, Mandal PK* “BHARAT: An Integrated Big Data Analytic Model for Early Diagnostic Biomarker of Alzheimer's Disease”. Frontiers in Neurology. vol.10: 9 (2019)

9) Deepika Shukla, Mandal PK*, Lars Ersland, Manjari Tripathi et al “A Multi-Center Study on Human Brain Glutathione Conformation using Magnetic Resonance Spectroscopy”Journal of Alzheimer’s Disease. vol. 66(2):517-532 (2018)

10) Mandal PK* and Deepika Shukla “Brain Metabolic, Structural, and Behavioral Pattern Learning for Early Predictive Diagnosis of Alzheimer’s Disease” Journal of Alzheimer’s Disease. vol 63(3):935-939 (2018)

11) Mandal PK*, A. Banerjee and Ankita Sharma “A Comprehensive Review of Magnetoencephalography (MEG) Studies for Brain Functionality in Healthy Aging and Alzheimer's Disease (AD)” Frontiers in Computational Neuroscience. vol.12:60 (2018)

12) Mandal PK*, Deepika Shukla, Varan Govind, Yves Boulard and Lars Ersland “Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy” Journal of Alzheimer's Disease. vol. 59 (2):537-541 (2017)

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13) Mandal PK*, Krity Kansara and Aroma Dabas “The GABA-Working Memory Relationship in Alzheimer's Disease” Journal of Alzheimer's Disease Reports. vol. 1(1):43-45 (2017)

14) R Prashanth, SD Roy, Mandal PK, S Ghosh “High-accuracy classification of parkinson'sdisease through shape analysis and surface fitting in 123I-Ioflupane SPECT imaging”IEEE journal of biomedical and health informatics. 21 (3): 794-802 (2017)

15) Monika Grewal, Aroma Dabas, Sumiti Saharan, Peter B. Barker, Richard A.E. Edden, Mandal PK* “GABA Quantitation using MEGA-PRESS: Regional and Hemispheric Differences” Journal of Magnetic Resonance Imaging. vol. 44(6):1619-1623(2016)

16) Suvarnalata Xanthate Duggirala, Sumiti Saharan, Partha Raghunathan, Mandal PK*“Stimulus-dependent modulation of working memory for identity monitoring: A functional MRI study” Brain and Cognition. vol. 102:55-64 (2016)

17) Mandal PK*, Sumiti Saharan, Oliver Penna, Vincenzo Fodale “Anesthesia Issues in Central Nervous System Disorders” Current Aging Science. vol. 9(2):116-43 (2016)

18) Mandal PK*, S Saharan, M Tripathi, G Murari “Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease” Journal of Biological Psychiatry. vol.78(10):702-10 (2015)

19) Mandal, PK*, S Saharan, S A Khan, M James “Apps for Dementia Screening: A Cost-effective and Portable Solution” Journal of Alzheimer's Disease. vol. 47 (4):869-72 (2015)

20) Mandal PK, “Brain Metabolic Mapping with MRS – A Potent Non- invasive Tool for Clinical Diagnosis of Brain Disorders” American Journal of Neuroradiology. vol 35(6):S1-3 (2014)

21) Mandal PK*, Ritchie K, Fodale V “Anesthetics and its Impact on the Brain and Alzheimer’s Disease.” Journal of Alzheimer's Disease. vol. 39(2):223-225 (2014)

22) R Prashanth, SD Roy, Mandal PK, S Ghosh “Automatic Classification and Prediction Models for Early Parkinson’s Disease Diagnosis from SPECT Imaging” Expert Systems with Applications. vol 41 (7):333–3342 (2014)

23) Joshi J, Saharan S, Mandal PK* “BOLDSync: A MATLAB-based Toolbox for Synchronized Stimulus Presentation in Functional MRI.” Journal of Neuroscience Methods. vol. 223:123– 32 (2014)

24) Saharan, S. and Mandal PK* "The emerging role of glutathione in Alzheimer's disease." Journal of Alzheimer’s Disease. 40(3): 519-529 (2014)

25) Mandal PK*, Akolkar H, Tripathi M, “Mapping of Hippocampal pH and Neurochemicals from in vivo Multi-Voxel 31P Study in Healthy Normal Young Male/Female, Mild Cognitive Impairment, and Alzheimer’s Disease” Journal of Alzheimer’s Disease. vol. 31(3):S75-86 (2012)

26) Mandal PK*, Joshi J, Saharan S. “Visuospatial Perception: An Emerging Biomarker for Alzheimer’s Disease” Journal of Alzheimer’s Disease. vol.31 (3):S117-35 (2012)

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27) Mandal PK*, Mahajan R, Dinov ID. “Structural Brain Atlases: Design, Rationale and Applications in Normal and Pathological Cohorts” Journal of Alzheimer’s Disease. vol. 31(3). p.169-188 (2012)

28) Mandal PK*, “Predictive Biomarkers for Alzheimer’s Disease using State-of-the-Art Brain Imaging Techniques” Journal of Alzheimer's Disease. vol. 31(3):1-3 (2012)

29) Mandal PK*, Tripathi M, Sugunan S. “Brain oxidative stress: detection and mapping of anti-oxidant marker 'Glutathione' in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy”Biochemical and Biophysical Research Communications. vol. 417(1) :43-48 (2012)

30) Mandal PK*, “In vivo proton magnetic resonance spectroscopic signal processing for the absolute quantitation of brain metabolites” European Journal of Radiology. 81(4):653-664(2012)

31) Mandal PK*, Akolkar H. "A new experimental approach and signal processing scheme for the detection and quantitation of 31P brain neurochemicals from in vivo MRS studies using dual tuned (1H/31P) head coil” Biochemical and Biophysical Research Communications. vol. 412(2):302-306 (2011)

32) Fodale V, Santamaria LB, Schifilliti D, Mandal PK*, “Anaesthetics and post-operative cognitive dysfunction: a pathological mechanism mimicking Alzheimer’s disease”Anesthesia. vol.65(4). p.388-395 (2010)

33) Schifilliti D, Santamaria LB, Rosa G, Di Nino G, Mandal PK*, Fodale V. “Cholinergic Central System, Alzheimer’s Disease, and Anesthetics Liaisons: a vicious circle?” Journal of Alzheimer's Disease.; vol. 22(3):35-41 (2010)

34) Mandal PK*, Ahuja M. "Comprehensive Nuclear Magnetic Resonance Studies on Interactions of Abeta with Different Molecular Sized Anesthetics." Journal of Alzheimer Disease. vol. 22(3):27-34 (2010)

35) Fodale V,* Ritchie K; Rasmussen LS, Mandal PK* “Anesthetics and Alzheimer's Disease: Background and Research. Preface” Journal of Alzheimer's Disease. vol. 22(3):1-3 (2010)

36) Mandal PK,* Bhavesh NS, Chauhan VS, Fodale V. “NMR investigations of amyloid-peptide interactions with propofol at clinically relevant concentrations with and without aqueous halothane solution” Journal of Alzheimer’s Disease. vol. 21(4):1303-9 (2010)

37) Fodale, V., K. Ritchie, L. S. Rasmussen and P. K. Mandal* “Anesthetics and Alzheimer's Disease: Background and research” Journal of Alzheimer's Disease. 22(s3): S1-S3 (2010)

38) Mandal PK*, Simplaceanu V, Fodale V. “Intravenous Anesthetic Diazepam does not induce Amyloid Beta-peptide Oligomerization but Diazepam co-administered with Halothane oligomerizes Amyloid Beta-peptide: An NMR study.” Journal of Alzheimer’s Disease. vol. 20(1):127-134 (2010)

39) Mandal PK, Schifilliti D, Mafrica F, Fodale V. "Inhaled Anesthetics and Cognitive Performance." Drugs of Today. Vol. 45(1):47-54, (2009)

40) Mandal PK*, Fodale V. “Smaller molecular-sized anaesthetics oligomerize Abeta peptide simulating Alzheimer’s disease: a relevant issue” European Journal of Anesthesiology. vol. 26(10):805-806 (2009)

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41) Mandal PK*, Fodale V. “Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: An NMR study” Biochemical and Biophysical Research Communications. vol. 379(3):716-720 (2009)

42) Mandal PK*, Pettegrew JW. “Abeta Peptide interactions with Isoflurane, Propofol, Thiopental and combined Thiopental with Halothane: A NMR Study.” Biochemica et Biophysica Acta. 1778 (1) 2633-2639 (2008)

43) Mandal PK*, Pettegrew JW. “Clinically relevant concentration determination of inhaled anesthetics (halothane, isoflurane, sevoflurane and desflurane) by 19F NMR.” Cell Biochemistry and Biophysics. vol.52 :31-35 (2008)

44) Mandal PK*, “Magnetic Resonance Spectroscopy (MRS) and its application in Alzheimer’s Disease.” Concepts in Magnetic Resonance Part A. 2007;30A:40-64 (2007)

45) Mandal PK,Pettegrew JW, Masliah E, Hamilton RL, Mandal R.

and Parkinson’s in Dementia with Lewy Body disease.” Neurochemical Research. 31:1153-1162 (2006)

46) Mandal PK, Pettegrew JW. -40) peptide in membrane mimic environment from solution NMR and CD studies”. Neurochemical Research. 29:2267-2272 (2004)

47) Mandal PK, Pettegrew JW. “Alzheimer Disease: NMR studies of AsialoGM1 and trisialo(GT1b) ganglioside interactions with Abeta(1-40) peptide in Membrane mimic environment” Neurochemical Research. 29: 447-453 (2004)

48) Mandal PK*, Majumdar M. “A Comprehensive Discussion of HMQC and HSQC Pulse Sequences” Concepts Magnetic Resonance. 20A:1-23 (2004)

49) Mandal PK*, McClure R, Pettegrew JW. -40) with GPC and Intact Erythrocyte Membranes: Fluorescence and CD Studies” Neurochemical Research. 29:2273-2279 (2004)

50) Yasamunov V, Mandal PK, Tang P, Xu Y. “NMR structure and backbone dynamics of the extended second transmembrane domain of the human neuronal glycine receptor alpha(1) subunit” Biochemistry. 42:3989-3995 (2003)

51) Tang P, Mandal PK, Xu Y. “NMR Structures of Second Transmembrane Domain of Human Glycine Receptor alpha(1) Subunit: Model of Pore architecture and Channel Gating” Biophysical Journal. 83: 252-262 (2002)

52) Madhu PK, Mandal PK, Mueller N. “Cross-correlation Effect in Curie spin Relaxation in Methyl Group” J Magnetic Resonance. 155:29-38 (2002)

53) Tang P, Mandal PK, Zegarra Z. “Effects of volatile anesthetic on channel structure of gramicidin A” Biophysical Journal. 83:1413-1420 (2002)

54) Mandal PK* “Complete NMR Spectroscopic Assignment of a Neuronal Transduction Protein.” Monatsheftefur Chemie. 133:205-217 (2002)

55) Madhu PK, Grandori R, Hohenthanner K, Mandal PK, Mueller N. “Geometry Dependent Two-Dimensional Heteronuclear Multiplet Effect in Paramagnetic Proteins.” Journal of

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Biomolecular NMR. 20:31-37 (2001)

56) Mandal PK, Madhu PK, Muller N. “Nuclear Magnetic Relaxation of Methyl Protons in a Paramagnetic Protein: Cross-correlation Effects.” Chemical Physics Letters. 320:269-276. (2000)

57) Schuffer C, Mueller N, Mandal PK, Christian R, Zayni S, MessnerP. “A pyrophosphate bridge links the pyruvate-containing secondary cell wall polymer of Paenibacillus alvei CCM 2051 to muramic acid.” Glycoconjugate Journal. 10:681-690 (2000)

58) deRopp, Mandal PK, Lamar GN. “Solution 1H NMR Investigation of the Heme Cavity and Substrate Binding site of Cyanine-Inhibited Horseradish peroxidase.” Biochemistry. 38:1077-1086 (1999)

59) Tochio H, Zhang Q, Mandal PK, Li M, Zhang M. “Solution Structure of the Extended Neuronal Nitric Oxide Synthase PDZ Domain Complexed with an Associated Peptide.” Nature Structural Biology. 6:417-421 (1999)

60) Jeffery deRopp, Mandal PK, Braur S, Lamar GN. “Solution NMR Study of the Electronic and Molecular Structure of Heme Cavity in High Spin Resting State Horseradish Peroxidase.” Journal of American Chemical Society. 119:4732-4739 (1997)

61) Mandal PK, Sinha B, Manoharan PT, Ramasesha R. “Diagrammetic Valence Bond Studies on Hemocyanin.” Theoretica Chemica Acta. 93:1-16 (1996)

62) AsokanA, Mandal PK, Vargese B, Manoharan PT. “Structure and Magnetism of an Exchange Coupled System: An NMR Approach.” Proc Indian Academy of Science. 107 ;281-295 (1995)

63) Mandal PK, Manoharan PT. “A Comprehensive Study of Exchange Coupling in a Macrocyclic Binuclear Copper (II) Complex in the Solid and Solution States.” Inorganic Chemistry. 34: 270-277 (1995)

64) Mandal PK, Manoharan PT. “Effect of Fifth Coordination Site on the Spin States of Bis (Benzoylacetylacetanato) Bis pyridine dicopper (II) Complex.” Chemical Physics letters. 210:463-470 (1993)

65) Mandal PK, Sinha B, Manoharan PT, Ramasesha S. “Theoretical Studies of Spin States of Macrocyclic Aza-amido Binuclear Copper (II) Complexes.” Chemical Physics letters. 191:448-454 (1992)

(Patents Granted/applied)

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Annexure - E


i) Title “KALPANA: A method for metabolite signal quantitation for Magnetic ResonanceSpectroscopy data”

International Patent Application No: PCT/IB2016/054978 (submitted for USA, Europe and home country- India)

Indian National Patent Application No: 201611001944, 19 Jan 2016

Funding: Ministry of Electronics and Information Technology (MEITY)

Role: Principal Inventor

It is an integrative platform for visualization, preprocessing and quantitation of MRS data acquired through MEshcher-GArwood Point-RESolved Spectroscopy (MEGA-PRESS) acquisition methods using single voxel as well as multi voxel magnetic resonance spectroscopy imaging (MRSI). The method integrates both time-domain as well as frequency-domain signal processing methods on a single platform. The method is optimized for proton (1H) and phosphorous (31P) MRS data. It employs iterative baseline estimation and fitting procedure to provide an improved quantitation accuracy. The method can be used in both interactive and automatic mode to cater the needs of researchers and clinicians.

ii) Title “An analytical and predictive tool using metabolic pattern learning”

National Patent Application No.: 201911019667, 17 May 2019 (USA, Europe andhome country- India)Funding: Ministry of Electronics and Information Technology (MEITY)Role: Principal Inventor

The present invention relates to a system that uses adaptive pattern recognition and learningschemes for predicting single or differential diagnosis, designed with magnetic resonance imagingmodalities and neuropsychological batteries. This invention employs principles of patternrecognition and machine learning to analyze variations of neurochemicals under the controlled anddiseased conditions. The integrated features in this embodiment comprise of metabolite peak areas,quantitative metabolite concentrations obtained through processing of proton (1H), Phosphorus(31P) or other multi-nuclei Magnetic Resonance Spectroscopy (MRS) data, anatomical changesinformation from processed and segmented MRI, neuropsychological evaluation scores forstatistical analysis to generate reliable multi-parametric diagnostic maps. The developed systemintegrates unimodal as well as multi-modal imaging data from various sources for statisticalanalysis to determine the potential biomarkers for diagnosing the neurodegenerative disorders atan early stage. Accuracy, recall, precision, f1-score, and receiver operating characteristic (ROC)analysis are the performance evaluation metrics based on which the diagnostic effectiveness of thedesigned system is determined. Besides, the beauty of this system lies in its ability to perform cross-sectional as well as longitudinal studies for diagnosis and prognosis of the disease.


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iii) Title “Synchronized Timing Integrated Module (STIM): A comprehensive FunctionalMagnetic Resonance Imaging Firmware”

Patent Application in progress for USA, Europe and home country- India

Status: patent application no 2020211021713; 23 May 2020

Funding: Ministry of Electronics and Information Technology (MEITY)

Role: Principal Inventor

STIM is composed of mainly three components: a versatile paradigm design system, synchronizedparadigm presentation system, and a response collection system which is used to study functionalmagnetic resonance imaging (fMRI). This integrated module is implemented into a user interfacefor interactive operation. Here, the paradigm design system allows designing an audio, video aswell as audio-visual based blocks. In addition, event-related and mixed fMRI paradigms are alsodesigned which can be saved in a variety of file formats. Consequently, it provides flexibility tointegrate with any MR system for stimulus presentation. On the other hand, the paradigmpresentation system coordinates the real-time synchronization of the presented paradigm with theradio frequency pulse of the MRI scanner and facilitates the presentation of synchronized stimuliwith precision and minimum delay response. After the completion of the fMRI experiment, theresponse collection system generates a comprehensive report comprising of the participant’sresponse accuracy and the participant’s response time. Overall, the system provides full freedomto the user for designing and run any paradigm by providing optimum performance as a standalonefirmware.

Annexure - F

(Technology Transferred/ Developed)

Research Modules and Software Developed

i) NINS-STAT: A Quasi Automated Statistical Analysis Software

NINS-STAT is a quasi-automated statistical analysis software primarily created to encourage easeof use. The software has been created keeping in mind people having no background or priorexperience in Statistical Analysis. NINS-STAT starts with asking basic questions that a user mightneed to ask before starting any research analysis. It is a MATLAB based graphical user interactive(GUI) system and simple group analysis and ROC curve generation.

ii) ANSH: A Database management system

ANSH is a comprehensive web-based SQL-driven database system which is developed in-house tooutreach the raw data generated from neuroimaging, spectroscopy, and neuropsychological test forthe worldwide research communities to achieve new outcomes in the field of AD research.Furthermore, the database can be extended to handle additional datatypes including EEG, MEG,pathological and biomarker testing reports. ANSH facilitates in maintaining the subject’s data whichcan be scaled further as per the requirements of a project or study.

iii) SUMEDHA: A GUI Toolbox for Quantitative Susceptibility Mapping Image Processing and

ROI Assessment

SUMEDHA is a MATLAB-based toolbox for processing and analyzing the QuantitativeSusceptibility Mapping (QSM) images. It enables the registration of QSM and structural imagingdata across subjects and allows for processing of user-defined regions of interest (ROI) in QSMimages. The toolbox also performs segmentation of structural imaging data along with theprocessing of QSM image information in the segmented regions.

iv) BRAHMA: Development of Population Specific MRI Brain Template for India

BRAHMA, a MATLAB-based toolbox providing a GUI-based MRI brain template constructionpipeline is being developed at the NINS Lab, NBRC. The toolbox utilizes structural MRI images toconstruct a brain template image, segmentation, and tissue probability maps that can be utilized forgenerating study-specific results. The toolbox provides an easy-to-use GUI-based interface tovarious other toolboxes and functions for constructing brain templates and shall be made availableto researchers upon completion.

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