P R O G R A M - TERMIS

P R O G R A MThe TERMIS

North America 2011Annual Conference

& ExpositionDecember 11-14, 2011

Hilton Americas-Houston • Houston, Texas

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Welcome… 2

General Information… 3

PRECONFERENCE WORKSHOP“Advances in Tissue Engineering for

Pediatric Applications”… 4-5

PRECONFERENCE WORKSHOPCells, Gels and Alginate - An Alginate Technology

Tutorial… 6

POST-CONFERENCE WORKSHOPRegenerative Medicine’s Challenge to Cure… 7-8

Agenda… 9-11

POSTER SESSION I,Monday, December 12, 2011… 12-15

POSTER SESSION II,Tuesday, December 13, 2011… 16-19

Student and Young Investigator Activities… 20-23

TERMIS NA Awards… 24-25

Sponsors… 26-28

Exhibitors… 29-32

Exhibitor Floor Plan and Booth Location… 33

TABLE of CONTENTSOPENING RECEPTION

Sunday, December 11, 2011 • 6:30 - 9:00 pm Located in the Exhibit Hall in the Grand Ballroom

Each attendee is required to check-in at the 2011 TERMIS NA Conference registration desk.

Photo ID is required at check-in.

WELCOME LETTER

December, 2011

Dear Fellow TERMIS Members and Guests:

On behalf of the TERMIS-NA, the scientific organizers, Dr. Jennifer West and Dr. Jane Grande-Allen, the scientific advisory board, and everyone involved in supporting the TERMIS-NA 2011 Conference and Expo, I would like to personally welcome you to Houston, Texas, and thank you for joining us!

The TERMIS-NA Annual Conference and Expo has now become the major venue for the presentation of basic tissueengineering and regenerative medicine research, and its clinical application. Our goal for this successful meeting is to continue to foster interactions among scientists engaged in discovery and development, translational researchers who bring scientific discoveries to the clinical forefront, and those engaged with funding, regulatory and commercial developments.

The main theme of this year’s meeting is “Scaffolds in Tissue Engineering: Bridging Matrix Biology and BiomaterialsScience.” The scientific co-organizers and advisory committee has put together an exceptional scientific program, which covers a wide range of topics with the field of tissue engineering, biomaterials, stem cells and regenerativemedicine. This year, we are pleased and excited to welcome our keynote lecturers: Kristi S. Anseth, Ph.D., Distinguished Professor, University of Colorado, Christopher S. Chen, M.D., Ph.D., Skirkanich Professor of Innovation in Bioengineering, University of Pennsylvania and Molly S. Shoichet, Ph.D., Professor of Chemical Engineering &Applied Chemistry, Chemistry and Biomaterials & Biomedical Engineering, University of Toronto.

These keynote lectures, together with presentations from invited experts and presentations from junior and new investigators, and the conference agenda, offer new insights from leading experts in our respected field. Altogether, theconference has 188 oral presentations, 302 poster presentations, and almost 40 sponsors and exhibitors. The numbersreflect the huge potential we have as a community as we continue our pursuit of excellence in our respective fields.

International and U.S.-based guests include a good mix of academicians, corporate professionals, and government representatives, with CEOs, principal investigators, post-doctoral fellows, pre-doctoral students, and other researchers.The conference provides a superb setting for networking, exchange and continued collaborations.

The Student and Young Investigator Section of North America (SYIS-NA) has again organized a number of excitingactivities at the meeting, specifically for newer investigators. The role of SYIS is to assist and encourage youngresearchers to network and interact with experts in the field and to foster personal professional development. Please see the SYIS-NA schedule of events in the program book or on meeting website (http://www.termis.org/na2011).

New full -day workshops include: Tissue Engineering for Pediatric Applications on Sunday, December 11 and“Regenerative Medicine’s Challenge to Cure” on Wednesday, December 14. A new tutorial featuring alginate technology will also be presented on Sunday. We are confident that you will benefit from these additional educationalprograms. On-site registration is an option pending space availability.

We are so very proud of TERMIS-NA and the progress this meeting has fostered for the tissue engineering and regenerative medicine community. This meeting is a gathering of the best research minds, all sharing our respectivepassion and pride in making strides in our research areas.

I encourage you to celebrate this week with us as we enjoy another stellar scientific program!

Sincerely,

Antonios G. Mikos, Ph.D., Conference Co-ChairLouis Calder Professor of Bioengineering, Chemical and Biomolecular EngineeringDirector, Center for Excellence in Tissue EngineeringDirector, J.W. Cox Laboratory for Biomedical EngineeringRice University

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GENERAL INFORMATION

SCIENTIFIC ADVISORY COMMITTEE

Jennifer West, Ph.D., Co-Organizer, Rice UniversityJane Grande-Allen, Ph.D., Co-Organizer, Rice University Anthony Atala, M.D., Wake Forest Institute for Regenerative MedicineJulia Babensee, Ph.D., Georgia Institute of TechnologyMalcolm Brenner, M.D., Ph.D., Baylor College of MedicineMary Dickinson, Ph.D., Baylor College of MedicineRobert Guldberg, Ph.D., Georgia Institute of TechnologyFarshid Guilak, Ph.D., Duke University Medical CenterKevin Healy, Ph.D., Univ of California, BerkeleyBrenda Mann, Ph.D., SentrXTodd McAllister, Ph.D., Cytograft Tissue EngineeringMichael Sefton, Ph.D., University of TorontoJames Yoo, M.D., Ph.D., Wake Forest Institute for Regenerative Medicine

ONSITE REGISTRATION AND CONFERENCE CHECK-IN

Photo ID is required at check-in. The registration desk will be open at thefollowing times:

• Sunday, December 11 from 7 am – 7 pm• Monday, December 12 from 7 am – 5 pm• Tuesday, December 13 from 7 am – 5 pm• Wednesday, December 14 from 7 am – 5 pm

Opening Reception

• Sunday, December 11, 2011• 6:30 – 9 pm• Lanier Grand Ballroom (Fourth Floor)

DISCLAIMERThe material presented at the TERMIS-NA 2011 Conference has been made available by theTissue Engineering and Regenerative Medicine International Society (TERMIS) for educationalpurposes only. The material is not intended to represent the only, nor necessarily best, methodor procedure appropriate for the medical situations discussed, but rather is intended to presentan approach, view, statement or opinion of the faculty which may be helpful to others whoface similar situations. Tissue Engineering and Regenerative Medicine International Society(TERMIS) disclaims any and all liability for injury or other damages resulting to any individualattending the meeting and for all claims which may arise out of the use of the techniquesdemonstrated therein by such individuals, whether these claims shall be asserted by physicianor any other person.

NOTICENo part of this publication may be translated or reproduced, in any form or by any means,without written permission from TERMIS- NA. No photography, video, audio recording orreproduction of any kind may be used during any portion of the TERMIS- NA 2011Conference. TERMIS NA reserves all of its rights to such materials, and commercial recordingor reproduction is specifically prohibited. This includes, but is not limited to, digital and filmphotography, videography, cellular phones, and other image or audio recording devices.

C O N G R A T U L A T I O N STO THE TERMIS-NA 2011

CONFERENCE AND EXPOSITION PLANNING TEAM

Antonios G. Mikos, Ph.D.Conference Co-Chair, Rice University

Jennifer L. West, Ph.D.Conference Co-Chair and Scientific Program Co-Chair, Rice University

K. Jane Grande-Allen, Ph.D.Scientific Program Co-Chair, Rice University

F. Kurtis Kasper, Ph.D.Local Arrangements Chair, Rice University

Executive Production Provided byForecast Technology Group

www.conferencestrategists.comAnita Caufield, MHA

Andrea Lubienski, CMPGina Saxton

Conference Liaison for TERMISSarah Wilburn

TERMIS-NA TreasurerBill Tawil

Special thanks to K. Jane Grande-Allen, Ph.D.Associate Professor, Rice University andJeffrey Jacot, Ph.D., Assistant Professor,

Texas Children's Hospital / Rice University fororganizing the Advances in Tissue Engineering

for Pediatric Applications Workshopand to

Mark E. K. Wong, DDS, Chairman and Program Director, Department of Oral and

Maxillofacial Surgery, The University of Texas School of Dentistry at Houston

for organizing the Regenerative Medicine'sChallenge to Cure Workshop.

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AUDIENCETissue engineers,

physicians (surgeons, cardiologists, obstetricians, neurologists, urologists),

research scientists, biomedical engineers and a range

of other experts and collaborative partners

WORKSHOP CO-CHAIRSK. Jane Grande-Allen, Ph.D.,

Associate Professor, Rice University

Jeffrey Jacot, Ph.D.,Assistant Professor, Texas Children’s

Hospital / Rice University

PRECONFERENCE WORKSHOP • SUNDAY, December 11, 2001

The promise regenerative medicine holds for curing a wide range of diseasesis a driving force behind many nationally recognized research teams. Whentargeting pediatric illnesses, landmark discoveries and breakthroughs especially offer renewed hope for children and families.

The ultimate goal is to someday transform kids’ lives who are suffering fromdevastating illnesses and birth defects, including muscular dystrophy, heartdisease, cleft palates, and kidney failure. Today, many investigators in thefield of tissue engineering cite congenital defects and the need to develop tissues that can grow as compelling justification for their research. However,pediatric applications actually represent a surprisingly small fraction ofresearch presented and published in the tissue engineering field.

This forum offers the opportunity to bring together disease-specific teams,comprised of researchers and clinicians exploring the most promisingapproaches. We are optimistic that by sharing our respective knowledge, we will be able to:

• Draw attention to the specific tissue engineering and regenerative medicineneeds of prenatal, neonatal, and pediatric patients;

• Clarify how needs for pediatric patients differ from the needs of adult patients;

• Inform all clinicians (including non-pediatric) about this research, especially those new to TERMIS-NA;

• Enhance collaboration and initiate discussions between pediatric clinicians and tissue engineering researchers; and

• Provide a platform to highlight the research of young investigators in the field of pediatric tissue engineering and regenerative medicine.

This forum will feature presentations describing research investigations onpediatric tissue engineering applications, including but not limited to: cardiovascular, orthopedic, maxillofacial, gastrointestinal, and urologicaldiscoveries. We will feature a program of invited speakers at various academic ranks from clinical and basic research institutions, with a specialemphasis on young investigators.

AGENDA

8:00 AM Registration and continental breakfast

9:00 AM Welcome and Introductory LectureCharles Fraser, M.D., Surgeon-in-Chief, Texas Children’s HospitalUrgent Need for Greater Focus on Pediatric Tissue Engineering

9:30 AM Keynote Lecture 1Hesham Sadek, M.D., Ph.D.Assistant Professor, Dept. of Cardiology, UT-SouthwesternRegeneration of Neonatal Hearts

“ADVANCES IN

TISSUE ENGINEERINGFOR

PEDIATRICAPPLICATIONS”

December 11, 2011 8:00am - 6:00pm

(Continued on following page)

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Derrick Wan, M.D.Assistant Professor, Plastic Surgery,

Stanford UniversityCraniofacial tissue engineering

James Yoo, M.D., Ph.D.Professor, Wake Forest Univ. Institute of

Regenerative MedicinePediatric genitourinary tissue engineering

3:00 PM Coffee Break

3:30 PM Keynote Lecture 3Alan Flake, M.D.Professor, University of Pennsylvania,

Pediatric SurgeryPrenatal corrections of fetal anomalies using

tissue engineering

4:30 PM Session 3: Tissue Engineering for Fetal/Neonatal Interventions

Presentations and Panel Discussion

Jun Liao, Ph.D.Asst. Prof., Mississippi State Univ.,

Biological EngineeringAmnion as a tissue engineering scaffold

David Morales, M.D.Associate Professor, Congenital Heart

Surgery, Texas Children’s HospitalSmall intestinal submucosa patches for

congenital heart defect reconstruction

Jeffrey G. Jacot, Ph.D.Assistant Professor, Congenital Heart Surgery,

Texas Children’s Hospital and Bioengineering, Rice University

Tissue engineering contractile patches and tubes for congenital heart defects

Jane Grande-Allen, Ph.D.Associate Professor of Bioengineering,

Rice UniversityDefining design goals and biomaterials for

pediatric tissue engineered heart valves

5:30 PM Concluding RemarksSpeaker to be identified

6:00 PM Reception

10:30 AM Session 1: Tissue Engineering for Pediatric Cardiovascular ApplicationsOral Presentations and Panel DiscussionChristopher Breuer, M.D.Assoc. Professor of Surgery (Pediatrics),

Yale-New Haven Children’s HospitalTissue engineering blood vessels for

pediatric surgery

Anita Driessen-Mol, Ph.D.Asst. Prof. of Biomedical Engineering,

Eindhoven University of TechnologyHeart valve tissue engineering for neonates

Jonathan Butcher, Ph.D.Assistant Professor of Biomedical

Engineering, Cornell UniversityMechanobiology of embryonic heart tissue

Daniel Teitelbaum, M.D.Professor, University of Michigan,

Department of SurgeryPediatric gastrointestinal tissue engineering

11:30 AM Lunch

1:00 PM Keynote Lecture 2Dario Fauza, M.D.Associate Professor of Surgery,

Children’s Hospital BostonTissue engineering of pediatric diaphragmatic

tendon, spine, and trachea

2:00 PM Session 2: Tissue Engineering for Pediatric Musculoskeletal and Urologic Applications

Oral Presentations and Panel Discussion

Laura Perin, Ph.D.Asst. Professor, Dept. of Urology,

USC / Children’s Hospital of Los AngelesAmniotic fluid derived stem cells for tissue

engineering of kidneys

Yong Li, Ph.D.Assistant Professor, University of Pittsburgh,

Stem Cell Research CenterUse of muscle stem cells for skeletal muscle

repair of DMD kids: Progress and Challenge


(AGENDA Continued from previous page)

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Alginate is a unique biopolymer that can be used to immobilize, entrap orencapsulate living cells by the instantaneous formation of an ionic cross-linked gel at physiological pH and temperature when an alginate solution comes into contact with calcium ions. This technology has beenused in the creation of cell therapy constructs such as encapsulated pancreatic islets. The alginate bead or capsule represents a biocompatiblebarrier between the immobilized cells and the body’s immune system. While the alginate bead system may be useful in several cell therapysituations, there is a need for larger constructs or shaping of injectable alginate gel structures. A second construct makes use of an injectable alginate solution that gels in situ. This “all-alginate” system of delayed gelling enables the formulation to be injected or implanted into tissue andirregular cavities before gelling. Thirdly, flexible alginate-based foams withadjustable structural integrity and biodegradation profiles have been developed as a matrix for culturing cells in 3D. The workshop will includethree “hands-on” stations where participants can make gels and immobilizematerials in alginate matrices.

PODIUM PRESENTATIONS(approximately 2.5 hours):

Introduction and purpose of the workshop (FMC presenter)

Experience with islet encapsulation for treating Type 1 diabetes (Invited presenter - Dr. Collin Weber, Emory University)

Development of Algisyl-LVR - an alginate-based medical device under clinical to prevent and reverse the progression of congestive heart failure -(Invited presenter - Mr. Frank Ahmann, LoneStar Heart)

Culturing cells in 3D in alginate foams - the importance of 3D culture in breast studies (Invited presenter - Dr. Simon Langdon, University of Edinburgh, UK)

Introduction to hands-on workshop - what we want to accomplish (FMC presenter)

HANDS-ON WORKSHOP (Workshop participants will be divided between three separate stations with rotation between stations) (approximately 2 hours):

Gelation - making macrobeads and microcapsules. Demonstration of calciumcross-linking of alginate and making macrobeads. Using an electrostatic beadgenerator for cell encapsulation and producing microbeads.

Self-gelling alginate - demonstration of an all-alginate, delayed gelling,injectable system.

Alginate matrix for 3D cell culture - demonstration of an alginate-basedmatrix for 3D cell culture. How to immobilize cells and how to recover cellular structures intact from foam matrix. Alginate foams as tissue engineering scaffolds.

CELLS, GELS AND ALGINATE -

AN ALGINATETECHNOLOGY

TUTORIAL

Sunday, December 111:00 - 5:00pm

OBJECTIVES:Participants should be able to understand the principles

of alginate and ionic gelation as well as potential applications

of alginate in various tissue engineering and regenerative

medicine applications. Participants will have made gels

as well as performed basic gelling and de-gelling examples. The workshop is intended

to give participants a working knowledge of this

biopolymer and to have experiencedsome of the alginate-based

technologies relevant to tissue engineering

and regenerative medicine.

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A new one-day symposium, designed to introduce and showcase the excitingpotential offered by the regenerative medicine research community.

Are you aware of the enabling technologies that are now available for thepracticing clinician?

This first of its kind, interactive symposium will serve as a dynamicopportunity to better understand opportunities for patient treatment within thegrowing field of tissue engineering and regenerative medicine. The forum willclose the TERMIS-NA 2011 Conference and Expo, and will provide a uniqueopportunity to participate in a non-structured setting. Experts will discuss how regenerative medicine is poised to change the landscape of modernmedicine. You’ll interact with global experts who have come to Houston forthe TERMIS-North America 2011 annual conference and recognized leaderswho are willing to share their knowledge and project insight.

ApproachResearch => Clinical Trials => Regulatory Pathways =>

Funding => Commercialization

By presenting the clinical pathways and challenges for some of the most disabling and debilitating diseases and injuries, researchers will offer in-depthdiscussions on the latest therapies available for several of the world’s mostproblematic diseases and injuries. They’ll also address therapies which offerthe most promise for near-term cures. Presenters will candidly describe thechallenges they have faced in discovering cures or treatments.

Each clinician will present the cause, the symptoms, the current treatment options and the results of a particular disease or injury. They will then lead a discussion with an audience of scientists, engineers, clinicians, biologists and others on the potential solutions to the challengesbeing presented.

Clinical translation including regulatory affairs, translational processes,funding and industry will be highlighted.

Focus areas include: Bone • Cartilage • Neural Tissue

By sharing our knowledge, you will be able to:• Identify the challenges you and your colleagues face on a daily basis,

and provide the latest therapy approaches in regenerative medicine and tissue engineering

• Discuss the obstacles encountered in clinical translation (funding, regulatory issues, etc) and ways to best overcome these issues.

• Come away with a clear understanding of the solutions that havebeen investigated to date, and how far have they come

• Participate with global experts who are specialists in orthopedics, neurology, rehab medicine

• Find out how close this industry is to discovering new applications for life-enhancing technologies

• Specific questions that will be discussed include: • What are the unmet clinical needs and opportunities for tissue engineering

and regenerative medicine therapies?• What are specific translational pathways for engineered tissues and

regenerative medicine therapies that could lead to clinical trial and therapeutic development?

• What are the practical clinician-based approaches, e.g. isolating cells for transplantation in a given office vs. having off-the-shelf products?

POST-CONFERENCE WORKSHOP • WEDNESDAY, December 14, 2011

REGENERATIVEMEDICINE’S CHALLENGE

TO CURE

December 14, 2011 9:15am - 4:00pm

AUDIENCEAll tissue engineering researchers

(scientists, bioengineers, clinicians) who have an interest in translational

research, moving basic researchtoward applications, and assessing

the efficacy and effectiveness of potential new treatments.

This is a must-attend symposium for any clinician involved in and will be of most value if you are a clinician,

medical student, resident, particularlyfrom orthotics orthopedics, neurologyneurosurgery, oral and maxillofacial surgery, plastic and reconstructive

surgery, otorhinolarygology,academia, industry, government and others experts who are involved in

translating scientific discovery into patient treatments.

WORKSHOP ORGANIZERMark E. K. Wong, DDS,

Chairman and Program Director,Department of Oral and Maxillofacial Surgery,

The University of Texas School of Dentistry at Houston


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POST-CONFERENCE WORKSHOP • WEDNESDAY, December 14, 2011

AGENDA

9:15 - 9:20 AM Welcome RemarksMark E. Wong, D.D.S., The University of Texas Health Science Center at Houston

9:20 - 10:00 AM Clinical Challenges in the BattlefieldJoseph C. Wenke, Ph.D., United States Army Institute of Surgical Research

10:00 - 10:40 AM Promise and Pitfalls of Tissue Engineering Circa 2011F. Kurtis Kasper, Ph.D., Rice University

10:40 - 11:20 AM Advances in Cartilage RegenerationJennifer H. Elisseeff, Ph.D., Johns Hopkins University

11:20 - 12:00 AM Cartilage Degeneration and its Impact on SocietyTerry A. Clyburn, M.D., The University of Texas Health Science Center at Houston

12:00 - 13:00 PM LUNCH

13:00 - 13:40 PM Meeting the Challenges in Nerve RegenerationMichael J. Yaszemski, M.D., Ph.D., Mayo Clinic College of Medicine

13:40 - 14:20 PM A Shortage of BoneMichael J. Miller, M.D., The Ohio State University

14:20 - 14:35 PM BREAK

14:35 - 15:15 PM Current and Future Strategies to Regenerate BoneRobert E. Guldberg, Ph.D., Georgia Institute of Technology

15:15 - 15:55 PM From Bench to Clinic: A Long and Winding RoadAnthony Ratcliffe, Ph.D., Synthasome, Inc.

15:55 - 16:00 PM Concluding RemarksMark E. Wong, D.D.S., The University of Texas Health Science Center at Houston

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8 am - 6 pm Advances in Tissue Engineering for Pediatric ApplicationsGrand Ballroom BC

1 - 5 pm Cells, Gels and Alginate - An Alginate Technology TutorialGrand Ballroom EF

6:30 - 9 pm Opening ReceptionGrand Ballroom ADGJ

S U N DAY • D e c e m b e r 1 1 , 2 0 1 1

M O N DAY • December 12, 2011

8 - 8:05 am Welcome Announcements • Grand Ballroom

8:05 - 9 am Plenary Speaker I - Kristi Anseth - User Programmable Biomaterial Niches for 3D Cell Culture and Tissue Regeneration • Grand Ballroom

9 - 9:30 am Award Announcement and Presentation - TERMIS-NA Senior Scientist Award: David Mooney “Cancer Vaccines Based on Tissue Engineering Strategies” and Mary Ann Liebert, Inc. Outstanding Student Award: Jessica DeQuach “Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds” • Grand Ballroom

9:30 - 10 am Coffee Break with Poster Viewing • Grand Ballroom

10 - 11:30 am Immunology and InflammationGrand Ballroom BC

Neural Tissue EngineeringGrand Ballroom EF

Decellularized TissuesGrand Ballroom HI

Nanobiotechnology - EMBS Joint SessionGrand Ballroom KL

11:30 am - 1 pm Lunch Break with Poster Viewing • Grand Ballroom

1 - 2:30 pm Controlled Release in Regenerative MedicineGrand Ballroom BC

Stem Cell SourcesGrand Ballroom EF

Vascularization of Engineered TissuesGrand Ballroom HI

Imaging and Assessment of Engineered TissuesGrand Ballroom KL

2:30 - 3 pm Break with Poster Viewing • Grand Ballroom

3 - 4:30 pm Scaffold MaterialsGrand Ballroom BC

Cell Processing and Preservation-AABB Joint SessionGrand Ballroom EF

Skin and Wound HealingGrand Ballroom HI

AFIRM SessionGrand Ballroom KL

4:30 - 6 pm Exhibit Viewing and Reception • Grand Ballroom

Poster Session 1Grand Ballroom

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8 - 8:05 am Announcements • Grand Ballroom

8:05 - 9 am Plenary Speaker II - Christopher Chen - Engineered Microenvironments: An Approach to Understand Cell Adhesion, Forces, and Assembly into Tissues • Grand Ballroom

9 - 9:30 am Award Announcement and Presentation - TERMIS-NA Young Investigator Award: Kurt Kasper and WFIRM Young Investigator Award Winners - Melissa Krebs and Brian Diekman • Grand Ballroom

9:30 - 10 am Coffee Break with Poster Viewing • Grand Ballroom

10 - 11:30 am Musculoskeletal SymposiumGrand Ballroom BC

Peripheral Nerve RegenerationGrand Ballroom EF

Hepatic and Endocrine Tissue EngineeringGrand Ballroom HI

Extracellular MatrixGrand Ballroom KL

11:30 am - 1 pm Lunch Break with Poster Viewing • Grand Ballroom

1 - 2:30 pm Musculoskeletal SymposiumGrand Ballroom BC

Mesenchymal Stem CellsGrand Ballroom EF

Cardiac Tissue EngineeringGrand Ballroom HI

Bioactive Scaffold MaterialsGrand Ballroom KL

2:30 - 3 pm Break with Poster Viewing • Grand Ballroom

3 - 4:30 pm Musculoskeletal SymposiumGrand Ballroom BC

Endogenous Stem Cell HomingGrand Ballroom EF

Scaffold FabricationGrand Ballroom HI

TERMIS-NA Industry Committee PanelGrand Ballroom KL

4:30 - 6 pm Exhibit Viewing and Reception • Grand Ballroom

Poster Session IIGrand Ballroom

T U E S DAY • December 13, 2011

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8 - 8:05 am Announcements • Grand Ballroom

8:05 - 9 am Plenary Speaker III - Molly Shoichet - 3D Biomolecule Patterned Hydrogels Guide Cell Growth and Differentiation • Grand Ballroom

9 - 9:15 am Coffee Break • Grand Ballroom

9:15 - 10:30 am Injectable BiomaterialsGrand Ballroom BC

Urologic and Renal Tissue EngineeringGrand Ballroom EF

Vascular Tissue EngineeringGrand Ballroom HI

Clinical DayGrand Ballroom KL

10:30 - 11:45 am Bioreactor TechnologiesGrand Ballroom BC

CancerGrand Ballroom EF

Engineering Heart ValvesGrand Balllroom HI


11:45 - 1:00 pm Lunch

1:00 - 2:30 pm Soft Tissue RepairGrand Ballroom BC

Mimicking Stem Cell NichesGrand Ballroom EF

Microfabrication and PrintingGrand Ballroom HI


2:30 - 2:45 pm Break

2:45 - 4:15 pm Gene TherapyGrand Ballroom BC

Stem Cell Differentiation and CharacterizationGrand Ballroom EF

Manufacturing and CommercializationGrand Ballroom HI


4:15 - 4:45 pm Award Announcement and Presentation - TERMIS-NA Lifetime Achievement Award: Robert Langer “Advances in Tissue Engineering” • Grand Ballroom

4:45 - 5:00 pm Closing Ceremony - World Congress 2012 - Congress President Heinz Redl and TERMIS-NA 2013 Conference Chair Robert Guldberg followed by the TERMIS-NAContinental Chair and 2011 TERMIS-NA Conference Co-Chair, Antonios MikosGrand Ballroom

5:00 pm Adjournment • Grand Ballroom

W E D N E S DAY • December 14, 2011

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POSTER SESSION I • Monday, December 12, 2011

ASSESSING ENGINEERED TISSUES IN VITRO AND IN VIVO

1 0424 Eunna ChungEffective Tracking of Adipose Tissue-Derived StemCells Seeded in a PEGylated Fibrin Gel usingGold Nanotracers for Dermal/Vascular TissueEngineering Applications

2 0440 Marta Raquel FontanillaReal-time quantification of autologous artificialconnective tissue (AACT) secreted factors using a surface plasmon resonance biosensor (SPR)

3 0417 Aurore Van de WallePlatelet adhesion to engineered vascular grafts

CELL SOURCING, PRESERVATION AND MANIPULATION

4 0112 JIN SAN CHOIOptimized Cultivation of Human CornealEndothelial Cells for Transplantation

5 0114 Ingrid GarzónIdentification of Highly Viable Human

Fibrochondrocytes for Use in Tissue Engineeringof the Temporo-Mandibular Joint

6 0375 Amelia HelmsFabrication of Size-Controlled Cell Aggregates for Functional Muscle Tissue Regeneration

7 0096 Alexander HuberCell-ECM Aggregates for the Targeted Delivery of Cells to Sites of Regeneration

8 0046 Theodore I MalininLong-term in Vitro Maintenance of Cultures of Hyaline Cartilage Engineered from Segregated Chondrocytes.

9 0165 Theodore I MalininImplantation of Non-human Primate ParticulateCartilage into Athymic Rats

10 0378 Gemma PalazzoloIsoquercitrin-Induced Changes in NeuronMorphology: Possible Applications in NeuralNetworks

11 0411 Xiaohui ZhangNanoliter Droplet Vitrification for OocyteCryopreservation

DECELLULARIZED TISSUE MATRICES

12 0339 Tamer AboushwarebOptimization of Decellularized Scaffolds forWhole Organ Engineering

13 0382 Siba HaykalEvaluation of the Structural Integrity andExtracellular Matrix Components of TrachealAllografts following Cyclical DecellularizationTechniques : Comparison of Three Protocols

14 0138 Nick J. MernaNon-invasive optical imaging of re-cellularizinga cardiac extracellular matrix

15 0505 Sayed-Hadi Mirmalek-SaniOptimized Decellularization of Porcine Kidneysfor Whole Organ Engineering

16 0175 Naoko NAKAMURAFabrication of Bone Marrow Niche usingDecellularized Bone Marrow

17 0519 Sophia PilipchukCrosslinking Influences Dermis-DerivedHydrogel Stiffness and Degradation

18 0398 Shay SokerInfluence of Flow Rate on Pressure and CellSeeding Efficiency in Decellularized LiverBioreactors

19 0232 John WilliamsProliferation and Chondrogenic Differentiation of Human Adipose Derived Stem Cells andHuman Mesenchymal Stem Cells in a Needle-Punched, Porous, Decellularized Human Allograft-Derived Meniscus

20 0117 Maelene L. WongSequential, Differential Solubilization for AntigenRemoval in Xenogeneic Scaffold Generation

21 0446 Janelle L. WongEffect of Chaotropes on Antigen Removal inXenogeneic Scaffold Generation

DEVELOPMENTAL BIOLOGY AND TISSUE MORPHOGENESIS

22 0068 Yoonyoung KimDynamic Change of Mitochondrial Distributionof Pluripotent Stem Cells-DerivedCardiomyocytes

23 0334 Catherine K KuoMechanical Loading Effects on EmbryonicTendon and Ligament Cells In Vitro Varieswith Developmental Stage and BiochemicalCues

24 0479 Alison P. McGuiganShear-induced Morphological Response ofHuman Umbilical Vein Endothelial Cells inMicrochannels

25 0498 Alison P McGuiganEngineering cell-cell interactions to control tissuemorphogenesis in endothelial cell sheets

26 0384 Kenneth J WalkerEffect of Thermosetting Chitosan-GelatinHydrogels on Chondrogenesis

NANOBIOTECHNOLOGY FOR REGENERATIVE MEDICINE

27 0263 Elshad AbdullayevDrug loaded Halloysite/Polycaprolactone scaffolds for wound healing

28 0520 Ashkan AryaeiStudy of effect of Zinc Oxide nanoparticles on mechanical properties of chitosan matricesusing AFM

29 0480 Rohan S. BalkawadeBioactive Nanomaterials for Enhanced WoundHealing

30 0443 Jong Kyu HongSingle Cell on Single Nanofiber in ThreeDimensional Scaffold

31 0486CLEMENTE IBARRA PONCE DE LEONCartilage tissue engineering for auricular reconstruction. The use of chitosan-polyvinylalcohol hydrogels.

32 0023 Binata JoddarCovalently Immobilized Hyaluronic AcidSubstrates for Maintaining Pluripotency andProliferation of Embryonic Stem Cells for In Vitro Tissue Engineering.

33 0139 David K. MillsBioactive Hydrogels for TMJ Repair

34 0450 David K. MillsEffects of Mechanical Shear on Anisotropic TissueEngineered Construct as Potential TMJ Repair

35 0259 Wenbo WeiClay Nanotube / Poly(methylmethacrylate) Bone Cement Composites with SustainedAntibiotic Release

36 0523 Stefan ZornDecorating tissue engineering scaffolds withmodular growth factors

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REPORTERS AND IMAGING FOR CELL TRACKING

37 0488 Khaled A. AamerLabel-Free Imaging of Prostate Cancer Cells byBroadband Coherent Anti-Stokes RamanScattering Microscopy

SKIN AND WOUND HEALING

38 0062 Luke R. BurnettKeratin Based Biomaterial (KeraHeal™) forTreatment of Cutaneous Radiation Injury

39 0222 Bin JiangInvestigation of Polyhexamethylene BiguanideContaining Poly(N-isopropylacrylamide)Hydrogels For Treatment of Infected Wounds

40 0143 Rutuja P KulkarniFunctionalized Nanofilms for AcceleratedWound Healing

41 0435 Yen-Chih LinHuman Adipose-Derived Stem Cell SheetsEnhance Wound Healing

42 0529 Glauco Souza3D Cell Culturing by Magnetic Levitation: The Bio-Assembler.

43 0200 Richelle C. ThomasThe Incorporation Of Electrically ConductingPolymers Within Biopolymer Hydrogels

44 0168 Cynthia E. Wilkins-PortAssessment of Dermagraft®Function in Mechanisms of Wound Repair


STEM CELL SOURCES, CULTURE AND CHARACTERIZATION

45 0203 Carlos Alberto AgudeloDesign of antibody-immobilized zwitterionictelomere brush surface for stem cell separationsystem

46 0324 Priya R BaraniakEffects of Human Platelet Lysate onMesenchymal Stem Cell Proliferation,Metabolism, and Senescence In Vitro

47 0308 Allison C BeanComparison of Chondrogenic Differentiation of Bone Marrow and Adipose-Derived Stem Cells Seeded on Electrospun Fibers of DifferentDiameters

48 0251 Barbara D. BoyanChondrogenic Media and Microencapsulation is Effective in Tailoring Adipose Stem Cell Trophic Factor Expression Regardless ofAnatomical Site, Passage, or Donor Age.

49 0437 Ana BrenaCulture of corneal limbal epithelial cells seededon a radioesterilized human amniotic membrane.

50 0255 Utkan DemirciLabel-free and Viable Stem Cell Isolation fromPeripheral Blood with a Disposable Microfluidic Chip

51 0116 Beena G. MohanThe effect of radio opaque strontium calciumphosphate implants loaded with autologous adipose derived mesenchymal Stem cells on the healing of lapine segmental bone defects

52 0057 Ingrid J GarzónGeneration of artificial human ectodermal tissuesusing an alternative cell source

53 0201 Ingrid GarzónComprehensive Gene Expression Analysis ofFibrous and Hyaline Chondrocyte Cultures forUse in Cartilage Tissue Engineering

54 0406 Sunil GeorgeThe Feasibility of using Autologous Renal Cellsfrom Diseased Kidneys for the Treatment ofRenal Failure55 0481 Adam HatchMicrofluidic Isolation of Endothelial ProgenitorCells for Tissue Engineering and Cell-BasedTherapeutics

56 0099 Niina M. HopperPeripheral Blood Derived Progenitor Cells inTissue Engineering57 0028 DIMITRIOS KOUROUPISEvaluation of mesenchymal stem cells (MSCs)from whole umbilical cord for bone repair applications

58 0442 Vijay KumarCharacterization of Bone marrow aspiratederived stromal cell (MSCs) concentrate for Mesenchymal cells (MSCs) using Res-QTM60 BMC- a point of care system

59 0333 Catherine K. KuoReducing cytoskeletal tension can modulate the effects of hypoxia on adipogenesis of mesenchymal stem cells

60 0135 Lisa M LarkinUtilization of Adipose-Derived Stem Cells to Fabricate Scaffold-less Tissue EngineeredNeural Conduits

61 0179 Wen-Chi C. LeeCytokine Secretion Profile of Leporine-derivedMesenchymal Stem Cells

62 0132 Yong Li MatrixMetalloproteinase Inhibition Negatively AffectsMuscle Stem Cell Behavior

63 0153 Yong LiA Cre-Lox system based study of muscle cellplasticity after skeletal muscle injury in adultmouse

64 0492 Brenda K. MannHA-Based Hydrogels Seeded with Equine CordBlood-Derived MSCs for Tissue Repair in Horses

65 0147 Ville V. MeretojaEnhanced Chondrogenesis in Mesenchymal Stem Cell Cultures Supplemented with Articular Chondrocytes

66 0426 George F MuschlerConcentration and Selection of OsteogenicProgenitors using Magnetic Labeling based onHyaluronan Expression for ImmediateTransplantation into a Canine FemoralMultidefect Model

67 0455 Haruko ObokataThe generation of pluripotent spheres from adult stem cells

68 0364 Jennifer J PetscheAmniotic Fluid-derived Stem CellCharacterization and Differentiation through Co-cultures with Neonatal Rat Cardiomyocytes

69 0542 Christopher ProctorMesenchymal Stem Cells and Bone MarrowConcentrate Proliferate and Synthesize Matrix on a Synthetic Scaffold

70 0294 Felicity Rose‘Smart Culture’ of Mouse Embryonic Stem Cells

71 0487 AL Sesman-BernalThe Periosteum osteogenic potential using scaffold demineralized bone with an acellulardermis

13

STEM CELL SOURCES, CULTURE AND CHARACTERIZATION (Continued from Previous Page)

72 0335 Eric SpinettiSkeletal Stem Cells Distribution in the HumanMarrow Cavity: High Frequency in theSubendosteal Region

73 0015 John A SzivekFocal Cartilage Defect Repair: A Co-CultureStudy with Adipose Derived Stem Cells andChondrocytes

74 0286 Ryo TakagiMesenchymal cell-like phenotype of normalhuman epidermal keratinocytes cultured in lowcalcium concentration medium

75 0371 Alan TsengAuricular Cartilage Reconstruction by BoneMarrow-Derived Mesenchymal Stem CellsGrown in Chondrocyte Conditioned Media

76 0508 Ashley M. WittVariablity of Male and Female Donors ofMesenchymal Stem Cells Derived from HumanUmbilical Cords

77 0522 Nicole L. WriceIsolation and Characterization of BaboonAdipose-Derived Stem Cells

78 0151 Wen Xu Stem CellsIsolated from Skeletal Muscle Differentiate intoNeural Phenotypes

79 0035 Yuanyuan ZhangEndothelial differentiation of human urinederived stem cells

80 0036 Yuanyuan ZhangNeural differentiation of human urine derivedstem cells: potential use in functional bladder tissue regeneration

81 0037 Yuanyuan ZhangIn vivo skeletal myogenic differentiationof human urine-derived stem cells: potentialapplication in the treatment of urinary incontinence

82 0038 Yuanyuan ZhangCharacterization of human urine-derived stemcells from the upper urinary tract for use in bladder regeneration in patients with end-stagebladder disease

83 0041 Yuanyuan ZhangFunctional urothelial differentiation of urinederived stem cells for potential use in urologicaltissue engineering


SYNTHESIS, FUNCTIONALIZATION ANDFABRICATION OF BIOMATERIALS

84 0260 Elshad AbdullayevEncapsulation and Controlled Release ofBioactive Agents by Biocompatible HalloysiteClay Nanotubes for Applications in Cosmetics

85 0346 Saniya AliInfluence of Cell-Adhesive Laminin Peptides onEndothelial Tubulogenesis

86 0309 Mária BahawdoryMechanistic Investigation of Cellular Adhesion to Keratin Biomaterials

87 0402 Eric M. BreyAngiogenesis in Engineered Tissues:Optimization via Computational andExperimental Analysis

88 0235 Pamela R Brown BaerInfluence of Porosity and rhBMP-2 on HealingUsing an Injectable Bone Regenerative Scaffold

89 0491 Mariana Carvalho BurrowsA Comparative Study of PET/collagen andPET/gelatin Hybrid Electrospun Scaffold as aModel for Vasculas Grafts

90 0351 Qingsu ChengIn-vitro evaluation of poly(lactide-co-gly-colide)/carbon nanotube scaffolds for bone tissueengineering

91 0432 Xingguo ChengElectrochemical aligned collagen sheet culturedwith mesenchymal stem cells (MSCs) for potential skin tissue regeneration applications

92 0240 Harish ChinnasamiRelating the Porosity of Poly (L-lactic acid)Scaffolds to Unidirectional Freezing (Thermal) Profiles

93 0128 Helen C CoxA Novel Injectable Scaffold For Bone RepairApplications

94 0083 Tanya M. FarooqueMeasuring 3Dness of Cell Morphology in TissueScaffolds

95 0434 Padraic J. FoleyAuto Cross-linking Polyelectrolyte Pairs toConformally Coat Individual Yeast Cells

96 0468 Jeffrey N HarrisCollagen and Polycaprolactone CompositeScaffold for Tissue Engineering

97 0269 Benjamin HarrisonElectrically Conductive Scaffolds Aiding SkeletalMyotube Formation

98 0270 Benjamin HarrisonBiodegradable Polymer Spheres LoadingAntibiotics and Iron Oxide Nanoparticles forControllable Drug Delivery

99 0415 Mohamad Nageeb HassanPreparation and Thermo-mechanicalCharacterization of 3D/Injectable PVA-BGComposite Hydrogel for Periodontal BoneRegeneration

100 0090 Xiaoming HeSmall (~ 100 µm) ACA(Alginate-Chitosan-Alginate) Microcapsules for Cell Microencapsulation

101 0511 Ting (Coco) HeNovel 3D Knitted Scaffolds for TissueEngineering Applications

102 0395 Ganesh C. IngavleBioactive Agarose-PEGDA InterpenetratingNetwork Hydrogels: Incorporation of CovalentlyLinked RGD Peptide and Entrapped AggrecanMolecules Improves Chondrocyte Viability andBiosynthesis

103 0171 Vaidehi JoshiMacro-Porosity Enhances Vascularization ofElectrospun Scaffolds

104 0271 Youngmee JungDevelopment of Non-Toxic and BioactiveScaffolds by Supercritical CO2 forTissue Engineering

105 0275 Cassandra M JuranMechanical Characterization of a Freeze-DriedXenogenic Acellular Fibrocartilage Scaffold forTemporomandibular Joint Disc Regeneration

106 0050 Kyung Shin KangThe effects of mussel adhesive protein on boneformation on solid free-form fabrication-basedPCL/PLGA scaffold

107 0458 Khadija KathiriaPreparation of Electrospun Fibers from Poly(glycerol dodecanoate co-fumarate) and their Cell Adhesion Studies

108 0363 Jongman LeeEffect of Controlled Delivery of PDGF-BB UsingHeparin-Conjugated Electrospun PCL/GelatinFibers on Bioactivity and Cellular Infiltration

109 0397 Nancy M LeeResponse of Human Periodontal Ligament-Derived Cells on Aligned PolymerNanofiber Scaffolds

110 0276 Tak Lung LiAntibacterial Properties of Novel 1D ZnONanowires on Medical Grade 316L StainlessSteel Surface

111 0267 Hang Lin AlginateMethacrylation in Dimethyl Sulfoxide forPhotopatterning Tissue Engineering Scaffolds

112 0331 Jenny B. LinPoly(N-isopropylacrylamide) Grafted ontoMicrotextured Poly(dimethylsiloxane) for Aligned Cell Sheet Engineering

14

SYNTHESIS, FUNCTIONALIZATION ANDFABRICATION OF BIOMATERIALS(Continued from Previous Page)

113 0265 Chase S LinsleyFabrication and characterization of multi-component biomimetic scaffold for bonetissue engineering

114 0150 Xiaohua LiuSurface Engineering of Nanofibrous GelatinScaffolds with Non-Collagenous Proteins forBone Regeneration

115 0256 Viviane LuangphakdyCompetitive Assessment of Polymer-based Bone Scaffolds in the Canine Femoral Multi-Defect model

116 0126 Claudia MONTERO-MENEIDevelopment of pharmacologically activemicrocarriers transporting stem cells and releasing growth factors integrated in a thermosensitive injectable hydrogel for an efficient tissue engineering

117 0445 Mayra Montes CamachoHuman Embryonic-Like Proteins as a NovelDevice Coating

118 0409 Marc C MooreUse of a Lyophilized Human Umbilical Vein as a Cell-Seeded Vascular Graft Cultured in aPerfusion Bioreactor

119 0081 Naveen NagiahElectrospinning of poly(3-hydroxybutyricacid)/gelatin fibrous membrane: Fabrication,characterization and application in skin regeneration

120 0060 Guoguang NiuComparison between electrospun poly(epsilon-caprolactone)/collagen scaffoldscross-linked with genipin and glutaraldehyde for vascular graft applications

121 0061 Guoguang NiuFabrication of gelatin hydrogel sheet forthe transplantation of cornealendothelium

122 0233 Jagdeep T. PodichettyDIFFUSIVITY AND PRESSURE DROP STUDIESIN FLOW-THROUGH AND PARALLEL-FLOWBIOREACTORS DURING TISSUE REGENERATION

123 0341 Rameshwar RaoMineralization of Cell-Seeded Collagen-ChitosanMatrices using Modified Culture Medium

124 0477 Julio C Rios CamachoA Simplified Method to Isolate FunctionalHuman Hemoglobin for Tissue EngineeringPurposes


125 0418 Maria A. RomeroIn Vitro Hydrolytic Degradation Studyof Porous and Non Porous Nerve GuidesFabricated with Biodegradable Polyesters

126 0074 S.I Roohani-EsfahaniIn-vivo bone regeneration in critical sizebone defect by using of nanocomposite scaffolds

127 0264Seyed-Iman Roohani-EsfahaniEffect of Nanofibrous Silk/PCL Modification on In-vitro Behaviour of Calcium PhosphateScaffolds

128 0245 Ariella ShikanovNatural and synthetic hydrogels for ovarian follicle culture in vitro.

129 0254 Tatsiana ShutavaLayer – by – Layer Nanoencapsulation ofAnticancer Drug Camptothecin

130 0368 Anirudha SinghThe stem cell behaviour on a multifunctionalsynthetic PEG hydrogel with independent controlof mechanical and bioadhesive properties.

131 0387 Marissa R. SolomonThe Design and Study of a PEG-ECM Hydrogelfor Controlled Cell-Mediated Cartilage Repair

132 0048 John A. SzivekA Novel Medial Condyle Surface ReplacementScaffold Facilitates Cartilage Regeneration

133 0278 Keisuke TakanariCreating a biohybrid material for fascial repair by regionally-controlled processing of an extracellular matrix digest with a biodegradable elastomer

134 0449 Nisarg M. TambeSurface Bioactivation and CollagenImmobilization on Polylactic Acid Fiber Scaffolds

135 0517 Richelle C ThomasPeptide Conjugation in Hyaluronic AcidHydrogels

136 0144 Tiffany N. VoInjectable PNiPAAm-Based Scaffolds withTunable LCST for Craniofacial BoneRegeneration

137 0210 Tzu-Wei WangDevelopment of Thermosensitive andBiocompatible Pluronic F127/Hyaluronic AcidHydrogel as Anticancer Drug Carrier

138 0236 Lisa J WhiteControlling the Morphology and MechanicalBehaviour of Supercritical Carbon DioxideFoamed Scaffolds

139 0239 Lisa J WhiteSpatio-temporal control of growth factor deliveryfrom PLGA microparticles

140 0207 Hsi-Chin WuIn Vitro Characterization of MagneticHydroxyapatite Nanocrystallines for TissueEngineering Applications

141 0056 Kelvin W. K. YeungEnhanced Cytocompatibility of BiomedicalMagnesium-Aluminum-Zinc Alloy by a Special Thermal Treatment

142 0211 Kelvin YeungA Novel Biodegradable Polycaprolactone-Magnesium Composite for Orthopaedic Applications

143 0010 Samer ZakyA Load-transducing Scaffold for BoneRegeneration

144 0514 Stefan ZornSpecific and reversible growth factor sequestering and release from PEG based Hydrogels

15

POSTER SESSION II • Tuesday, December 13, 2011

ARTIFICIAL STEM CELL NICHES

1 0299 Karla S HudsonDifferentiation of Human Adipose DerivedMesenchymal Stem Cells on DemineralizedCancellous Bone Grafts Under OsteogenicConditions.

2 0181 Kaiming YeEnhanced Human Embryonic Stem CellProliferation and Differentiation byPhysicochemical Cues

BIOREACTOR TECHNOLOGIES

3 0459 Keith BaarDefined electrical stimulation parametersemphasizing excitability for the developmentand testing of engineered skeletal muscle

4 0283 Yuki KagawaA Feasibility Study on Monitoring the State ofCulturing Myocardial Tissues by the GlucoseMetabolism Measurement

5 0049 Kyung Shin KangThe effects of a low-frequency electromagneticfield on osteogenic differentiation of human adipose-derived stem cells

6 0471 Vincent H PaiCharacterizing Strain of a Bioreactor for RabbitCorneal Fibroblasts – Experimental Verification of Finite Element Models

7 0221 Subha Narayan RathOsteoblasts and Bone-Marrow Stromal Cells inThree-Dimensional Biphasic Calcium PhosphateScaffolds: The Effect of Bioreactor on CellSurvival and Differentiation

8 0332 Joseph S. UzarskiPhysiologically Modeled Shear Stress as aFunction of Pulse Frequency: Driving EndothelialCells Toward a Quiescent Phenotype

9 0231 Andrew B. YeattsTowards Vascularized Bone: Dynamic Culture of hMSCs and Endothelial Cells in a TubularPerfusion System

CANCER

10 0104 Jacob E ShokesCharacterization of Chemotherapy / RadiationTreated Human Smooth Muscle Cells for Use in Regenerative Medicine

CARDIAC AND CARDIOVASCULAR

11 0377 Juna Arenas-HerreraElectrospun Vascular Scaffold for EngineeringCellularized Small Diameter Blood Vessel

12 0416 Hesham AzizgolshaniTissue Engineering a Bio-inspired Pump fromBiological Building Blocks

13 0085 Jean-MIchel BourgetAlignment of Vascular Cells via MicropatternedSurfaces Improved Vessel Properties

14 0475 George J. ChristSMOOTH MUSCLE CELLS CONFER EARLYFUNCTIONAL REMODELING OF TISSUE ENGI-NEERED ARTERIO-VENOUS FISTULA GRAFTSIN AN OVINE MODEL

15 0355 Emily A GonnermanAnisotropic Collagen-GlycosaminoglycanScaffolds Differentially Promote Beating in HL-1Cardiomyocytes

16 0072 Binata JoddarArterial pO2 Modulates PathologicalRemodelling in Human Saphenous Veins via an eNOS- and Superoxide-dependent Pathway

17 0347 Lucrezia A MorticelliInvestigation of the Suitability of DecellularisedPorcine Pericardium for Mitral Valve Repair

18 0164 Jochen RingeHuman Endomyocardial Biopsy DerivedAdherent Proliferating Cells Improve CardiacFunction In Vivo

19 0521 Marsha W RolleA cellular self-assembly approach to generatemodel human vascular tissue

20 0472 Michael S. SacksUse of finite deformation during in-vitro conditioning dramatically enhances de novoextracellular matrix production and mechanical properties.

21 0428 Zehra TosunImproved recellularization of engineered scaffolds using directed transport gradients

22 0142 Bo Wang MyocardialScaffold-based Cardiac Tissue Engineering:Application of Coordinated Mechanical andElectrical Stimulations

23 0193 Feng ZhaoIn-Vivo Remodeling of Scaffold-free Small-diameter Blood Vessels with AlignedHuman Mesenchymal Stem Cells

CLINICAL TRIALS

24 0305 Clemente IbarraTwo Year Follow Up of Arthroscopic Implantationof Matrix-Seeded Autologous Chondrocytes atthe Knee

25 0186 Jonathan MansbridgeStimulation of Hair Growth by Hypoxic Cell-Secreted Proteins

DISEASE MODELS AND DRUG TESTINGPLATFORMS

26 0380 Lauren D. Black IIIThe Development of a Fibrin Gel BasedEngineered Myocardium Model of MyocardialInfarction

27 0441 Jon CheethamThe horse as a preclinical model for regenerative medicine approaches for laryngealreconstruction

28 0536 Paul C. SchillerRegenerative Capacity of MIAMI Cells isMediated by the Repair and FunctionalModulation of Multiple Tissue Compartments

ECM AND MECHANOTRANSDUCTION

29 0319 Matthew T. HarrisA Method for Aligning Cells and ApplyingHomogenous Tensile Strain in Collagen Gels

30 0095 Rami MhannaThe Effect of Chondrocyte Morphology on theirResponse to Mechanical Compression

31 0451 John H. SlaterSimultaneous Investigation of the Influences ofBiophysical & Biochemical Cues on DirectionalCell Migration

32 0414 Justin S. WeinbaumMonitoring Collagen Expression in MechanicallyStimulated Bioartificial Arteries

33 0526 John M WilliamsNovel Tensile Strain Bioreactor for Analysis ofPrimary Cilia-Extracellular Matrix Interactions inAdipose-Derived Stem Cells

ENDOGENOUS STEM CELL HOMING34 0390 Anusuya DasSphingosine-1-Phosphate (S1P) Receptor SpecificSmall Molecules Modulate Endogenous StemCell Homing for Bone Regeneration

IMMUNOLOGY AND TISSUE RESPONSES35 0527 Siwoo ChoHigh Function and Viability of a IsletTransplantation Capsule with a AnodicAluminum Oxide Nanochannel Membranes withSelective Blocking Immunoglobulin G

36 0399 Bailey V. FearingA Keratin Biomaterial Promotes a BeneficialInflammatory Response Following Spinal CordHemisection Injury

16

IMPACT OF ECM COMPOSITION ON CELLFATE AND TISSUE FORMATION

37 0470 Ben AntebiSecretion of Extracellular Matrix RepressesProliferation of Mesenchymal Stem Cells in 3DCultures

38 0213 Stephen F BadylakThe Consequences of IneffectiveDecellularization on the Host Response toBiologic Scaffolds

39 0425 Sarah CalveHyaluronic Acid Content in Skeletal Muscle isIncreased via Upregulation of HAS2 and HAS3During Muscle Hypertrophy

40 0379 Kelly C. ClauseStiffness as an Effector of Lung BranchingMorphogenesis

41 0311 Joaquin CortiellaProduction and Evaluation of Acellular PigTrachea-Lung Scaffold

42 0310 Anita Driessen-Mol VitaminStimulation to Enhance Collagenous and ElasticNetwork Formation by Human Adult VascularCells in Valvular and Vascular Tissue Engineering

43 0499 Monica FahrenholtzCell-derived ECM on CaP scaffold enhanceshBMSC behaviour and delivery of BMP-2

44 0230 Kimberly M. FerlinCentrifugation Adhesion Assay for Characterizingthe Phenotype of Chondrocytes

45 0361 Sunyoung JooIn vitro generation of three-dimensionalfunctional ovarian structures

46 0321 Kathryn A KuklaEvaluation of Adipose ECM Gels for BreastReconstructive Surgery

47 0325 Catherine K KuoElaboration of mechanical and biochemicalproperties of embryonic tendon during development

48 0439 Wan-Ju LiSynergistic Effect of Surface Topography andChemistry of Extracellular Matrix on Regulationof Osteogenesis

49 0242 Jeremy J LimDesulfated Chondroitin Biomaterials UpregulateGene Expression of Cartilaginous ECM byHuman Mesenchymal Stem Cells in the Presence of TGF-‚1

50 0174 Ivan Marcos-Campos Bone ScaffoldArchitecture Affects Developmentof Bone Grafts from Human Embryonic StemCells


51 0360 Eric HD NguyenEnhanced-Throughput Screening of EndothelialCell Interactions with Synthetic, BioactiveHydrogels

52 0124 Neerav D. PadliyaA Mass Spectrometry-Based Proteomic Methodto Profile Proteins Secreted by Cells Interactingwith the Extracellular Matrix

53 0317 Yongzhi QiuDegradability of MMP-Sensitive HydrogelsModulates Cell Shape and Early OsteogenicDifferentiation of iPS-Derived Mesenchymal-likeCells

54 0422 Ana Y. RiojaFibrillar Collagen for Tendon Tissue Engineering

55 0403 Thomas D ShupeGrowth factor retention on decellularized ratliver matrices derived from normal and regenerating liver.

56 0452 Aleksander SkardalThe Impact of Substrate Elasticity on AmnioticFluid-Derived Stem Cell Phenotype

57 0178 Patricia S SoucyEndothelial cell response to poly ethylene glycol hydrogels containing basic fibroblastgrowth factor

58 0058 Bill J. TawilAssessment of Keratinocyte and FibroblastMigration on Fibrin and Collagen Matrices ofDifferent Compositions on a Novel 3D SkinEquivalent Wound Model

59 0091 Yuanyuan ZhangTissue Specific 3D Gel Culture Model ForFunctional Cell Culture

MANUFACTURING, SCALE-UP ANDAUTOMATION

60 0127 Mohit B. BhatiaDevelopment of a High Yield Process for theIsolation of an Extracellular Matrix from theHuman Placenta Amenable to CommercialProduction

MICROFABRICATION, PRINTING, ANDPATTERNING TECHNOLOGIES

61 0134 Peter D. GabrieleFiber Nanopattern Features Using HighDefinition Microextrusion (HDME)

62 0290 Aaron GoldsteinFabrication of a 3D PLGA/PEGDA Scaffold forLigament Tissue Engineering

63 0052 Akiko HisadaA Novel Spheroid Culture Device withNanopillar for Cryopreserved HumanHepatocytes

64 0496 Brett C IsenbergStructural and mechanical properties of patterned cell sheets for arterial tissue engineering

65 0032 Liyang Jiang3-D Assembly of HUVECs on Patterned HydrogelMatrices: A Model for Microvessel Engineering

66 0367 Hyun-Wook KangDevelopment and Validation of an IntegratedOrgan Printing System

67 0464 Vivek A KumarGenereation of mechanically robust collagen-based biomaterials with defined laser ablated patterns for soft tissue engineeing.

68 0337 Vivian A LeBioprinting by Continuous Material Deposition

69 0284 JunHee LeeFabrication and Characterization of PLLA/PDOBlended Scaffold using 3D Plotting System

70 0501 Neethu MohanMicrosphere-based continuous gradient scaffoldfor effective regeneration of the osteochondralinterface

71 0359 Sang-Hyug ParkBiofabrication of Muscle Scaffolds using anIntegrated Organ Printing System for theEngineering of Functional Muscle Tissue

72 0300 Felicity RoseNovel Method to Develop Electrospun FibreBased Scaffolds with Tailored Geometries

73 0192 Jeff SakamotoPatterning highly ordered and hierarchical hydrogels for nerve repair

74 0413 Michael J. SawkinsBioprinting as a Novel Tool for OsteochondralTissue Engineering

75 0190 Binil StarlySpatially Printed Electrically ConductivePoly-Pyrrole (PPy) Ultra-Fine Fibers Embeddedwithin 3D Poly-Caprolactone (PCL) Porous 3D Scaffolds

76 0289 Wojciech SwieszkowskiFetal or Adult Mesenchymal Stem Cells and 3DComposite Scaffolds for Bone Tissue Engineering

77 0157 Halil TekinMimicking biological complexity via dynamicmicromolding

78 0209 Kisuk YangMicrofluidic Platform for Quantitative Analysis of Neural Stem Cell Differentiation in 3DExtracellular Matrix Microenvironment

17

MUSCULOSKELETAL, CRANIOFACIAL AND DENTAL

79 0419 James BlanchetteOsteogenic differentiation of adipose derivedstem cells in varied oxygen concentrations

80 0008 Jose A CansecoEnhanced Ligament Marker Expression By Direct Co-Culture Of Pig Mesenchymal StemCells (MSCs) And Primary Anterior CruciateLigament (ACL) Cells

81 0261 Kelly Chen-LeungEarly Assessment of Volumetric Muscle LossRepaired With Muscle Derived ExtracellularMatrix

82 0195 Benjamin T. CoronaTissue Engineered Skeletal Muscle RepairConstructs Mediate Functional Recovery in a Rat Model of Volumetric Muscle Loss Injury

83 0122 Tracy L. CriswellCell therapy for the treatment of compartmentsyndrome in rats.

84 0014 James DennisTantalum-cartilage-Mesenchymal Stem CellComposites for Joint Repair

85 0338 Warren L GraysonInducing Mesenchymal ‘Condensation’ Enhances Subsequent Chondrogenesis of MSCs

86 0301 Allan M HensleeDevelopment of a Biodegradable Bone Cementfor Craniofacial Applications

87 0353 Chang Mo HwangA Tissue Engineered Cartilage CoveredAlloplastic Implant for Auricular Reconstruction

88 0223 Esmaiel JabbariEffect of BMP2 peptide grafted nanoparticles on osteogenic expression of stromal cells encapsulated in a hydrogel

89 0224 Kyobum KimDual Growth Factor Release from BilayeredOligo(poly(ethylene glycol) fumarate) Hydrogels

90 0349 Jaehyun KimIn Vitro Osteogenic Differentiation ofHuman Amniotic Fluid-derived Stem Cellswithin Hybrid Scaffolds for Bone Tissue

Engineering

91 0474 Ann LeeMuscle-tendon-bone constructs engineered withfunctional musculoskeletal interfaces

92 0025 ZF LuBone structure-mimicking scaffold andOsteoblasts Synergistically Induce OsteogenicDifferentiation of Adipose Tissue-derivedMesenchymal Stem Cells


93 0509 Venkata MantripragadaCharacterization of chitosan microparticles forsustained release of growth factor and studyits effect on osteoblast cell attachment and proliferation

94 0381 Sang-Hyug ParkCell laden gelatin fiber contained calcium phosphate biomaterials as a stem cell deliveryvehicle for bone repair

95 0106 Elizabeth L Pettit KnellerHuman Skeletal Muscle Myoblast Growth andDifferentiation on Keratin Biomaterials

96 0408 Christopher R. RathboneSurvival of Freshly Isolated Stem Cells DeliveredAfter Ischemia-Reperfusion Injury

97 0478 Shaun A. TannerControlling the Release Profile of FTY720 inOrder to Guide Tissue Regeneration in CranialBone Defects

98 0506 W.Y. TongRoughened substrate suppress proliferation ofmesenchymal stem cells and is associated withcell-cell contact.

99 0013 Dong-An WangA Novel Scaffold-Free Living Graft for TissueRegeneration

100 0039 Anna E. WilhelmPhotocrosslinked PEG Microwells for Synthesisof Cartilage Micropellets and Study ofInflammatory Responses

101 0019 Masaya YamamotoEnhanced osteogenesis and angiogenesis of bone marrow-derived cells by controlled release of growth factors and chemokines toinduce bone regeneration.

102 0293 Li ZengTissue engineering under inflammatory conditions: the effect of scaffold material on cartilage stability

NEURAL

103 0545 Jared BushmanRe-Tasking an FDA-Approved Drug for Use inPeripheral Nerve Regeneration

104 0045 Lauren E. CornellAligned Carbon Nanotube-Collagen Fibers andTheir Use in Guiding Neuron Progenitor CellGrowth

105 0076 Dong Nyoung HeoCell fouling resistant PEG coating on polyimidefilms for neural implant applications

106 0160Seyed Abdolreza Mortazavi TabatabaeiAUTOLOGOUS GRAFT TRANSPLANTATIONOF NEURAL CELLS VIA ENDOMETRIAL STEMCELL NEUROGENESIS

PEDIATRIC, FETAL, OR NEONATALAPPLICATIONS

107 0089 Thomas W. GilbertIn Vivo Assessment of MagnesiumAlloys for Potential Use as a Degradable Stent for Treatment of Pediatric Airway Obstruction

108 0167 Ariella ShikanovFibrin-mediated delivery of an ovarian folliclepool in a mouse model of infertility

109 0094 Miho WatanabePreliminary Optimization of Cellular Seeding ofGelatin Scaffolds for Fetal Treatment ofMyelomeningocele

PRE-CLINICAL STUDIES

110 0173 Benjamin T KibaloMatriStem MicroMatrix®-based HaemostaticDressings are Effective in Acute Haemorrhage.

111 0252 Haofan PengA novel arterio-venous shunt model for testingtissue engineered vascular grafts from hair follicle stem cells

REGULATORY AND COMMERCIALIZATIONISSUES

112 0279 Michael DornishTissue Engineered Medical ProductStandardization - the ASTM InternationalCommittee F04

18

SOFT TISSUE REPAIR

113 0454 Ellen M. ArrudaTissue Engineered Bone-Ligament-BoneConstructs Following 9-Month ACL replacementin Sheep

114 0214 Stephen F BadylakBiologic Scaffolds for Skeletal MuscleReconstruction

115 0348 Chang Mo HwangIn vitro and In vivo evaluations of a fibrin/alginate hybrid hydrogel for soft tissue repair

116 0196 Jacob KofflerThe relay race to integration of engineered vascularized graft

117 0148 Yong LiIschemia Reperfusion Induces Fibrosis Formation in the Skeletal Muscle of Mice

118 0152 Yong Li Regeneration of Soft Tissues is Promoted by MMP1Administration after Digit Amputation in Mice

119 0185 Mon-Tzu A LiQuantitative Characterization of a NovelVolumetric Muscle Loss Model in the Rat

120 0345 Nelson L. ScarboroughInfluence of processing methodology and source on porcine dermis biological responsesand biophysical characteristics.

121 0285 Kelvin WK YeungFlexible, Channeled Nerve Guidance Conduit

122 0065 Yuanyuan ZhangImplantation of autologous urine derived stemcells expressing vascular endothelial growth factor for potential use in the treatment of neurovascular erectile dysfunction


UROLOGIC

123 0502 Sigrid M. AgcaoiliPrimary Renal Cell Seeding in a FullyDecellularized Porcine Renal Scaffolds,Preliminary Results of Cell Organization

124 0009 Hazem OrabiTissue Engineering of Smooth Muscle fromAdipose Tissue Derived Stem Cells forGenitourinary Reconstruction

125 0059 Gustavo VilloldoDIFFERENCES IN URETHRAL REGENERATIVEPATTERNS POST URETHROPLASY USINGSMALL INTESTINE SUBMUCOSA IN A RABBITMODEL WITH INJURED URETRHA

VASCULARIZATION OF ENGINEERED TISSUES

126 0354 James O. Blanchette CuingRelease of Angiogenic Factors from Adipose-Derived Stem Cells (ADSCs) Using Hypoxia:Towards Vascularization of Tissue-EngineeredBioscaffolds

127 0066 Nolanne ChangOptimizing Components of an AngiogenicScaffold System for Bone Regeneration

128 0079 Tracy L. CriswellThe use of fluorescent imaging to detect the neovascularization and differentiation of skeletalmuscle in vivo.

129 0386 Omaditya KhannaMultilayered alginate microbeads for the localstimulation of neovascularization

130 0026 Yu Bin LeeDevelopment of Dual-Factor ImmobilizedSubstrates Using Bio-Inspired Coating Method for The Stimulation of Angiogenesis

131 0199 Ayelet LesmanEngineering Vessel-Like Networks withinMulticellular Fibrin-Based Constructs

132 0266 Kristen M LippertEnhanced Vascular Migration in CD47-nullTrachea133 0018 Lei TianImpact of Pericytes on Vessel Formation andAnastomosis in Prevascularized Tissues

134 0055 Maxime TondreauA human tissue-engineered vascular substitutewith a nitric oxide-producing vasa vasorum

19

December 2011

Dear Students, Young Investigators, and Conference Attendees,

Welcome to Houston and thank you for joining us at TERMIS-NA 2011!

The TERMIS Student and Young Investigator Section North America (SYIS-NA) Meeting Committee has prepared a special program for students and post-docs to foster career development and encourage networking and interaction with experts in the field. We hope you enjoy our program and find it stimulating!

The SYIS program opens on Monday afternoon with a Career Panel during the coffee break from 2:30-3:00 PM. Come hear about career paths from experts in academia, industry and the NIH. Monday evening, the SYIS is hosting a reception at the BioScience Research Collaborative building on Rice University’s campus. Come and enjoy drinks and hors d’oeuvres and tours of laboratories in the building.

On Tuesday, join us for the Student Meet Mentor Lunch (sign-ups at registration). Don’t miss this opportunity to havelunch and talk with leaders in the field of regenerative medicine. Want to take a more active role in the student activities of TERMIS- NA SYIS? Join us for the annual SYIS- NA Business Meeting during the coffee break on Tuesdayfrom 2:30-3:00 to learn how you can be a part of SYIS and the future of regenerative medicine.

SYIS is excited to sponsor the SYIS- NA Poster Competition. The top 25 student and young investigator posters (authors were notified prior to the conference) will be judged by senior faculty members, with awards for 1st place($300), 2nd place ($200), and 3rd place ($100). Poster award winners will be announced on Wednesday after thePlenary Lecture at 8:00 AM.

We hope you have a fantastic TERMIS- NA Meeting and look forward to meeting you!

Kind Regards,

Patrick Spicer Sayed-Hadi Mirmalek-Sani SYIS- NA Meeting Chair SYIS- NA Chair

Christine Kowalczewski Chris BashurSYIS- NA Vice Chair SYIS- NA Secretary

Rebecca Dahlin Robert GauvinSYIS- NA Treasurer Scientific & Professional Development Committee Chair

STUDENT WELCOME LETTER

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TERMIS- NA STUDENT & YOUNG INVESTIGATOR SECTION (SYIS)

SYIS POSTER COMPETITIONJudging: Monday, Dec 12th & Tuesday, Dec 13th,

4:30-6:00 PM at Poster Sessions

Awards: Wednesday, Dec 14th, after the 8:00 AM Plenary Talk

The top 25 young investigator posters, as scored by theabstract reviewers (authors were notified prior to the

conference), will be judged by selected faculty.SYIS Poster Competition posters will remain up for both

Poster Sessions I and II. Awards for 1st place ($300), 2nd place ($200), and 3rd place ($100) will be given.

SYIS RECEPTION AND LABORATORY TOURS AT THE BIOSCIENCE RESEARCH COLLABORATIVE

OF RICE UNIVERSITYMonday, December 12th

6:30-9:00 PM • Rice UniversityMeet in the hotel lobby at 6:00 PM

for shuttle service to Rice University.Reception for SYIS member at Rice University with

hors d’oeuvres and drinks. Tours of laboratories investigating tissue engineering and regenerative medicine will be given

by students of Rice University.

2 0 1 1 P R O G R A M

CAREER PANELMonday, December 12th

2:30 – 3:00 PM • Grand Ballroom KLA panel made up of representatives from academia,

industry and the NIH. Come and hear about career pathsthrough each of these areas.

SYIS- NA BUSINESS MEETINGTuesday, December 13th

2:30-3:00 PM • Grand Ballroom KLThe annual TERMIS SYIS-NA business meeting is open

to all students and young investigators. Attend this meeting to learn more how to get involved in SYIS.

STUDENT MEET MENTOR LUNCHTuesday, December 13th

12:00-1:30 PM • Room 335ABThe Student Meet Mentor Lunch gives 51 SYIS members the opportunity to enjoy a plated lunch with 17 mentors,

with seating arranged by student preference. Mentors include Session Chairs, members of the Scientific

Advisory Committee, and local industry leaders. Sign-ups at the registration desk.

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STUDENT POSTER COMPETITION

ARTIFICIAL STEM CELL NICHESS 1Ben AntebiEffect of Oxygen Tension on theProliferative Activity of MononuclearCells and Human Mesenchymal StemCells

ASSESSING ENGINEERED TISSUES INVITRO AND IN VIVOS 2Joseph UzarskiDevelopment of a Novel Flow ChamberFor Real-time (Direct) Analysis of Blood-Biomaterial Interactions

CARDIAC AND CARDIOVASCULARS 3Aditya KumarIn Vitro Modeling of the Effect ofGentamicin on Aortic Valve InterstitialCell CalcificationS 4Tracy GwytherCell-Derived Vascular Tissue TubesGenerated by Fusion of Aggregated CellRings

CELL SOURCING, PRESERVATION AND MANIPULATIONS 5Warren GraysonXeno-Free Conditions for the EndothelialDifferentiation of Adipose-Derived Stem Cells

DISEASE MODELS AND DRUG TESTING PLATFORMSS 6RebeccaHaydenModulating Bone Formation andResorption with Tethered PTH for a TissueEngineered Model of Osteoporosis

GENE THERAPYS 7Keerthana DevarajanAdenoviral Mediated Gene Delivery toHuman Umbilical Cord MesenchymalStromal Cells for Inner Ear Hair CellDifferentiation

IMPACT OF ECM COMPOSITION ONCELL FATE AND TISSUE FORMATIONS 8Jeremy MercuriAssessment of Human Stem CellDifferentiation on a Biomimetic Scaffoldfor Nucleus Pulposus Tissue Engineering

S 9Marilyn MarkowskiModulation of epithelial to mesenchymaltransition through the control of theextracellular matrix microenvironment

S 10Partha DebTowards Correlating Spatio-TemporalVariations in ECM Microenvironmentswithin Abdominal Aortic Aneurysms(AAAs) to Cellular Responses to MatrixRegenerative Therapies

CRANIOFACIAL AND DENTALS 11Allison BeanEffects of Seeding Density and FiberDiameter on Chondrogenesis ofMesenchymal Stem Cells In Vitro

S 12Alan TsengAdvances in the Development ofEngineered Ear

S 13Olive MwizerwaReplacement Innervated andVascularized Skeletal Muscle forCraniomaxillofacial Reconstruction

S 14Peter YangTensile Culture Upregulates TendonFibroblast Genes in MSCs EncapsulatedWithin Enzyme-Sensitive PEG Hydrogels

NEURALS 15Gary CatigExperimental and Computational Modelsof Neurite Outgrowth in Response toControlled Diffusive Gradients inMicropatterned

SKIN AND WOUND HEALINGS 16Sukeerth ChallagundlaDesign of Smart Nanofilms with bFGFand PDGF-BB for Wound Repair

CULTURE AND CHARACTERIZATIONS 17 Brian DiekmanChondrogenesis of Induced PluripotentStem Cells: Purification of DifferentiatedCells for Tissue Engineering

S 18Nicole WriceDebrided skin: a source of autologousstem cells for wound repair and regeneration

S 19Ami AminiComparative Analysis of EndothelialProgenitor Cells Isolated from PeripheralBlood and Bone Marrow for EnhancedVascularization in Bone TissueEngineering Applications

FUNCTIONALIZATION ANDFABRICATION OF BIOMATERIALSS 20Aubrey FranciscoLaminin-Functionalized Biomaterials forIntervertebral Disc Regeneration

S 21Christopher DosierManipulating Hydrogel Formation toPromote Prolonged Cell Viability in vitro

S 22Christopher HermannNovel Click-Hydrogel Therapy forJuvenile Murine Model of Re-Synostosis

S 23Michael TurturroPEGDA Hydrogel Gradients Produced byPerfusion Based Frontal PolymerizationStimulate Directed Cell Invasion

VASCULARIZATION OF ENGINEERED TISSUESS 24Seema EhsanIntermittent hypoxia conditioning of invitro vascularized tissue

S 25Yu-Chieh ChiuControlled Neovascularization withinPorous Poly (ethylene glycol)

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TERMIS-NA Conference and Exposition 2011

The Wake Forest Institute for Regenerative Medicine is committed to the development and dissemination of novel therapies for the repair and replacement of diseased tissues and organs. One way to achieve this goal is to foster thecareers of young investigators to encourage them to find solutions to problems in regenerative medicine. As part of thiseffort, the Wake Forest Institute for Regenerative Medicine Young Investigator Award was first awarded at the TERMIS-NA Conference and Exposition in 2008. The award is designed to recognize outstanding achievements bymembers of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) who is in the early stagesof a career in regenerative medicine.

The award consists of a certificate, $2500 cash prize, and recognition at the 2011TERMIS-NA Conference and Expo. We are pleased to announce this year’s winners: Brian O. Diekman and Melissa Krebs, Ph.D.

Brian O. Diekman is a Ph.D. student in Biomedical Engineering at Duke University and a NationalScience Foundation Graduate Research Fellow. He is a member of the Orthopaedic ResearchLaboratories and is advised by Dr. Farshid Guilak. He has authored seven publications, including a 2010 paper in Tissue Engineering that investigated a cartilage-derived matrix scaffold with adipose-derived and bone marrow-derived stem cells for cartilage tissue engineering. Brian’sresearch on characterizing murine mesenchymal stem cells from MRL/MpJ “superhealer” miceearned distinction as one of the 50 best abstracts at TERMIS-EU in 2010. His current work involvescellular therapy approaches for the prevention of post-traumatic arthritis, as well as using

differentiated induced pluripotent stem cells to model cartilage healing. After earning a B.S in Biomedical Engineeringfrom Duke in 2005, Brian received a Fulbright Student Grant to perform stem cell research at the RegenerativeMedicine Institute in Galway, Ireland. Brian is active in the Durham community through coaching youth basketball and tutoring high school math.

Melissa Krebs, Ph.D. is an American Cancer Society Postdoctoral Fellow and a ResearchAssistant Professor in Biomedical Engineering at Case Western Reserve University in Cleveland,OH. She is a member of Eben Alsberg’s lab at Case Western Reserve University, and is currentlyperforming research as a Visiting Scientist in Douglas Graham’s cancer biology lab at Universityof Colorado - Denver. Melissa received a B.S. and M.S. in Chemical Engineering from theUniversity of Rochester in 2002 and 2003, respectively. She then worked as a member of thetechnical staff in bioengineering at Charles Stark Draper Laboratory, Inc. in Cambridge, MA,from 2003-2006; her work at Draper was primarily focused on the development of a hand-heldion mobility spectrometer for applications in biodefense and medical diagnostics. She returnedto graduate school to pursue a Ph.D. in Biomedical Engineering in the field of biomaterials andtissue regeneration from 2006-2010, and was awarded a National Science Foundation GraduateFellowship. In her thesis research, Melissa developed biopolymer scaffolds for the controlled release of bioactive factorsto aid in tissue regeneration. Specifically, she was interested in promoting bone formation by guiding the differentiationof mesenchymal stem cells down the osteogenic lineage through gene delivery. Her current studies are focused on thecontrolled, localized delivery of short interfering RNA (siRNA) from biopolymer hydrogels, with applications both in tissue regeneration and cancer therapeutics.

Congratulations to Brian and Melissa!

WAKE FOREST INSTITUTE FOR REGENERATIVE MEDICINE YOUNG INVESTIGATOR AWARD

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LIFETIME ACHIEVEMENT AWA R D :Robert S. Langer is the David H. Ko ch Institute Professor(there are 14 Institute Professors at MIT; being an InstituteProfessor is the highest honor that can be awarded to afaculty member). Dr. Langer has written more than 1,140articles. He also has approximately 800 issued and pending patents wo r l dwide. Dr. Langer’s patents havebeen licensed or sublicensed to over 220 pharmaceutical,chemical, biotechnology and medical device companies.He is the most cited engineer in history.

He served as a member of the United States Food andDrug A d m i n i s t ra t i o n ’s SCIENCE Board, the FDA’s highesta dvisory board, from 1995 — 2002 and as its Chairmanfrom 1999-2002.

D r. Langer has received over 200 major awa r d sincluding the 2006 United States National Medal ofScience; the Charles Stark Draper Prize, considered thee q u ivalent of the Nobel Prize for engineers, the 2008Millennium Prize, the wo r l d ’s largest technology prize and the 2012 Priestley Medal, the highest award of theAmerican Chemical Society. He is the also the only engineer to receive the Gairdner Foundation InternationalAward; 72 recipients of this award have subsequentlyr e c e ived a Nobel Prize. Among numerous other awa r d sLanger has received are the Dickson Prize for Science(2002), Heinz Award for Te ch n o l o g y, Economy andE m p l oyment (2003), the Harvey Prize (2003), the Jo h nFritz Award (2003) (given previously to inventors such asThomas Edison and Orville Wright), the General MotorsKettering Prize for Cancer Research (2004), the Dan Dav i dPrize in Materials Science (2005), the A l b a ny MedicalCenter Prize in Medicine and Biomedical Research (2005),the largest prize in the U.S. for medical research, inductioninto the National Inventors Hall of Fame (2006), the MaxP l a n ck Research Award (2008) and the Prince of A s t u r i a sAward for Te chnical and Scientific Research (2008). In

TERMIS- NA AWARD PROGRAM • 2011 AWARDEES


1998, he received the Lemelson-MIT prize, the wo r l d ’slargest prize for invention for being “one of history’s mostprolific inventors in medicine.” In 1989 Dr. Langer wa selected to the Institute of Medicine of the NationalA c a d e my of Sciences, and in 1992 he was elected to boththe National A c a d e my of Engineering and to the NationalA c a d e my of Sciences. He is one of very few people eve relected to all three United States National Academies and the youngest in history (at age 43) to ever receive this distinction.

Forbes Magazine (1999) and Bio Wo r l d (1990) havenamed Dr. Langer as one of the 25 most important i n d ividuals in biotechnology in the world. D i s c ove rM a g a z i n e (2002) named him as one of the 20 most important people in this area. Forbes Magazine ( 2 0 0 2 )selected Dr. Langer as one of the 15 innovators wo r l dwide who will reinvent our future. Time Magazine a n dCNN (2001) named Dr. Langer as one of the 100 mostimportant people in America and one of the 18 top peoplein science or medicine in America (America’s Best).Pa rade Magazine (2004) selected Dr. Langer as one of 6“Heroes whose research may save your life.” Dr. Langerhas received honorary doctorates from Harvard Unive r s i t y,the Mt. Sinai School of Medicine, Yale Unive r s i t y, the ETH(Switzerland), the Te chnion (Israel), the Hebrew Unive r s i t yof Jerusalem (Israel), the Universite Catholique de Louva i n(Belgium), Rensselaer Po l y t e chnic Institute, Wi l l a m e t t eU n ive r s i t y, the University of Liverpool (England), BatesCollege, the University of Nottingham (England), A l b a nyMedical College, Pe n n s y l vania State Unive r s i t y,Northwestern Unive r s i t y, Uppsala University (Sweden) andthe University of California – San Francisco Medal. Her e c e ived his Bach e l o r ’s Degree from Cornell University in1970 and his Sc.D. from the Massachusetts Institute ofTe chnology in 1974, both in Chemical Engineering.

SENIOR SCIENTIST AWA R D :D avid J. Mooney D r. David Mooney is a pioneer in the tissue engineering and biomaterials fields, and has also made significant impact through his professional and educational activities and the translation of inventions from his labora t o r yto industry. His work is helping to move tissue engineering from its empirical beginnings to a discipline based on fundamental scientific and engineering principles. He has published extensive l y, with over 14,000 citations and an h-index of 76. On the translational front, twelve companies have taken licenses to patents on wh i ch Dr. Mooney is ani nve n t o r, and biomaterials developed in his laboratory for tissue engineering and regenera t ive medicine have been successfully commerc i a l i z e d .

The Mooney laboratory has repeatedly identified key roadblocks in the tissue engineering and regenera t ive medicinefield, and subsequently developed new technologies that bypass or hurdle these roadblocks. One of his most significantr e s e a rch contributions to date is the invention of polymers that allow single or sequential delivery of growth factors tobuild highly functional new networks of blood vessels (angiogenesis on demand) (Nature Biotechnol. 1 7 : 5 5 1 - 5 5 4 , 1 9 9 9 ;Nature Biotechnol. 19:1029-1034, 2001). Vascularization is one of the greatest challenges in tissue engineering, and Dr.Mooney has pioneered approaches to create highly functional blood vessels that have been demonstrated to prevent limbloss and alleviate complications of coronary artery disease in animal models, and more broadly to enhance the surviva land function of various transplanted stem cells. This approach has been shown to have particular promise in promotingbone and skeletal muscle regeneration. His laboratory has also developed hydrogels to transplant cells wh i ch allow oneto both direct the organization of these cells into complex multicellular structures (e.g., growth-plate like structures; P NA S

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99:12025-12030, 2002), and to control their stage of differentiation and participation in regeneration (P NA S105:14347-52, 2008). He has also made seve ral important research contributions at the intersection ofm e chanics and biology, including (1) the identification ofthe role of cyclic strain in growth factor transport (N a t u r e408:998-1000, 2000), (2) the impact of adhesion substra t em e chanical properties on plasmid DNA uptake in localgene thera py (Nature Materials 4(6):460-4, 2005), (3) therole of specific adhesion ligands in the response of engineered tissues to external strain (Nature Biotech n o l .,17:979-983, 1999), and (4) the control of stem cell fate in3D culture by substrate elastic modulus (Nature Materials.9(6):518-26, 2010). Quite recently, his laboratory hasd e veloped materials that can program and reprogram theimmune system (Nature Materials. 8(2):151-8, 2009). Th i shas led to the first demonstration that a cancer vaccine cancause regression of established skin tumors in mice(Science Trans. Res. 1(8):8-19, 2009), and this approach of using biomaterials to modulate the immune systems h ows promise in addressing the chronic inflammationunderlying many diseases in wh i ch tissue engineerings t rategies are currently being applied. A common theme to this work is the discovery of fundamental biological

TERMIS- NA AWARD PROGRAM • 2011 AWARDEES

(Continued from previous page) principles to guide tissue regeneration, and the subsequentd e velopment of cell instructive materials based on theseprinciples that precisely regulate the gene expression ofcell populations within tissues via temporal and spatialcontrol of both chemical and mechanical cues.

D r. Mooney was a Founding Member of the Ti s s u eEngineering Society (the precursor to TERMIS), served asits Scientific Director, and Chaired the Program Committeefor one of its first International Meetings (Orlando, FL2000). He has served on the Board of Governors of TERMIS, and on the Editorial Board and Executive EditorialBoard of Tissue Engineering. He developed one of the firstcourses in Tissue Engineering, and has taught this courseto thousands of students at Michigan and Harvard over the past 17 years. He has been an active mentor to tissueengineering Ph.D. students and post-doctoral fellows (> 70 PhD students and post-docs mentored; 17 currentlyh ave tenured or tenure-tra ck appointments). His contributions have led a variety of honors, including election to the National A c a d e my of Engineering, theSociety for Biomaterials Clemson Award, IADRDistinguished Scientist Award, NIH MERIT Award, NatureB i o t e chnology SciCafe Award, and Einstein Visiting Fe l l ow(Einstein Fo u n d a t i o n - B e r l i n ) .

YOUNG INVESTIGATOR AWA R D :F. Kurtis Kasper presently holds an appointment as Faculty Fe l l ow in the Department of Bioengineering at Rice Unive r s i t y.He received his B.S. in Biomedical Engineering from Case Western Reserve University in Cleveland, Ohio (1999) with anemphasis on polymeric biomaterials. From 1997-1999, he studied the effects of myxomatous tissue changes on them e chanical properties of the mitral heart va l ve at the Cleveland Clinic Foundation. He earned his Ph.D. inBioengineering in 2006 from Rice Unive r s i t y. In conjunction with his graduate work, Kasper served as a visitingr e s e a rcher over the summer of 2004 at the Institute for Frontier Medical Sciences at Kyoto University in Kyoto, Ja p a n .K a s p e r ’s doctoral research invo l ved the application of polymeric biomaterials toward non-viral gene delivery for bone tissue engineering. His postdoctoral training at Rice University (2006-2008) focused upon the application of novel biomaterials and adult-derived stem cell culture techniques for the generation of hematopoietic bone.

K a s p e r ’s research focuses upon the development and evaluation of novel materials and approaches for the r e g e n e ration of orthopaedic tissues, including bone and cartilage. He is the author of over a dozen publications and hascontributed significantly to the preparation of an undergraduate level textbook focused on biomaterials (Biomaterials: Th eIntersection of Biology and Materials Science, Pearson Prentice Hall, 2008).

Kasper is a member of the American Society for Engineering Education (ASEE), the Tissue Engineering Internationaland Regenera t ive Medicine Society (TERMIS), the Biomedical Engineering Society (BMES), the Society for Biomaterials(SFB), and the Controlled Release Society (CRS). He has been recognized with various fellowships and awards, includinga Nanobiology Training Fe l l owship through the W.M. Ke ck Center for Interdisciplinary Bioscience Training of the GulfCoast Consortia (2007), the Sallyport Award for University and Community Service (Rice Unive r s i t y, 2006), an NSFI n t e g ra t ive Graduate Education and Research Traineeship (IGERT) (2001-2003), and the Jose Ricardo Alcala MemorialAward for Biomedical Engineering Research (1999). Apart from his professional service, Kasper remains actively engagedwith Rice University and the greater community through various leadership positions and volunteer projects.

M A RY ANN LIEBERT, INC. OUTSTANDING STUDENT AWA R D :Jessica DeQuach r e c e ived her B.S. in Biomedical Engineering from Case Western Reserve Unive r s i t y. She then went toUC San Diego to earn her PhD in Bioengineering, where she is a member of the Biomaterials & Regenera t ive MedicineLab run by Dr. Karen Christman. Jessica is developing tissue specific matrices for treating ischemia in the brain, skeletalmuscle, and heart as well as cell culture coatings for stem cell and progenitor differentiation. Jessica also received the 2011 Siebel Scholar awa r d .

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CONFERENCE SPONSORS

ORGANIZER:

The Tissue Engineering & Regenerative Medicine International Society (TERMIS) brings together theinternational community of persons engaged or interested in the field of tissue engineering and regenerative medicine and promotes education and research within the field of tissue engineering and

regenerative medicine through regular meetings, publications and other forms of communication. The Society alsoserves as an international forum to promote the informed discussion of challenges and therapeutic benefits of the application of tissue engineering and regenerative medicine technologies. Most importantly, the Society is committed tobringing you closer to key professionals to support your mutual understanding of the field, accelerate your researchin the field and to enable you to contribute to the ultimate care of patients in this very important way. To affect thisinterchange of information, the Society has endorsed the journal, Tissue Engineering, Parts A, B and C, as its official publication and has negotiated a reduced subscription rate for members. www.termis.org

PLATINUM SPONSOR:

Kinetic Concepts, Inc. is a leading global medical technology company devoted to the discovery anddevelopment of innovative, high-technology therapies and products for the tissue regeneration, wound

care and therapeutic support system markets. Headquartered in San Antonio, Texas, the Company employs 7,100 peopleand brings its healing therapies to serve the needs of clinicians and patients around the world. www.kci1.com

Celgene is a global biopharmaceutical companycommitted to delivering truly innovative and life-changingtherapies to patients. The Cellular Therapeutics Divisionof Celgene is committed to the discovery, developmentand commercialization of novel human cell and tissuebased therapeutic products for the treatment of severeand debilitating diseases. http://www.celgene.com/

Covidien is a leading global healthcare products company that creates innovative medical solutions forbetter patient outcomes and delivers value through clinical leadership and excellence. Covidien manufactures, distributes and services a diverse range of industry-leading product lines in three segments:Medical Devices, Pharmaceuticals and Medical Supplies.With 2010 revenue of $10.4 billion, Covidien hasapproximately 42,000 employees worldwide in morethan 60 countries, and its products are sold in over 140countries. Please visit www.covidien.com to learn moreabout our business.

Elsevier Science & Technology Books has provided award-winning education resourcesto researchers worldwide and is pleased topublish Principles of Regenerative Medicine,

2nd edition, by Atala, Lanza, Thomson and Nerem. It isthe first book of its kind to offer an advanced understand-ing of the latest technologies in regenerative medicine.http://www.elsevierdirect.com/stemcells

The Wake Forest Institute for Regenerative Medicine’smission is to improve patients’ lives through regenerativemedicine therapies. Its scientists engineered the first laboratory-grown organs to be implanted into humans.The team currently is working to engineer more than 30 different organs and tissues and to develop cell therapies to restore organ function. http://www.wakehealth.edu/wfirm/

SILVER SPONSORS:

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CONFERENCE SPONSORS (Continued)

HOST AND CONFERENCE SPONSOR:

As a leading research university with a distinctive commitment to undergraduate education, RiceUniversity aspires to path-breaking research, unsurpassed teaching, and contribution to the bettermentof our world. It seeks to fulfill this mission by cultivating a diverse community of learning and

discovery that produces leaders across the spectrum of human endeavor. Since 2006, Rice has been guided by a 10-point strategic vision in furtherance of its mission.

The university must (1) increase its commitment to research and to raising its research and scholarship profile; (2) provide a holistic undergraduate education that equips its students to make a distinctive impact; (3) strengthen itsgraduate and postdoctoral programs; (4) aggressively foster collaborative relationships with other institutions to leverageits resources; (5) invest in a select number of interdisciplinary endeavors that will enable it to leverage its strengths aswell as those of potential collaborators; (6) continue to invest in its professional schools and seek ways to integrate theirsuccess into the broader university; (7) increase the size of the university; (8) become an international university; (9) provide the spaces and facilities that will cultivate vibrancy and community; and (10) fully engage with the city of Houston. http://www.rice.edu/

PRE-CONFERENCE WORKSHOP SPONSORS:

NovaMatrix, a business unit of FMC BioPolymer, provides well-characterized, ultrapure alginate,water-soluble chitosan salts and hyaluronic acid for use in drug delivery, tissue engineering, cellencapsulation, and medical device applications where functionality and regulatory documentation

are important. Our new NovaMatrix 3-D cell culture system expands research possibilities in regenerative medicine.www.novamatrix.biz

Texas Children’s Hospital is committed to a community of healthy children by providing the finestpediatric patient care, education and research. Renowned worldwide for its expertise and breakthrough developments in clinical care and research, Texas Children’s is nationally ranked in all10 subspecialties in U.S.News & World Report’s list of Best Children’s Hospitals. Texas Children’s alsooperates the nation’s largest primary pediatric care network, with more than 40 offices throughout the

greater Houston community. Texas Children’s has embarked on a $1.5 billion expansion, Vision 2010, which includesthe Jan and Dan Duncan Neurological Research Institute, a comprehensive obstetrics facility focusing on high-risk births and a community hospital in suburban West Houston. For more information on Texas Children’s Hospital, go towww.texaschildrens.org. Get the latest news from Texas Children’s Hospital by visiting the online newsroom and onTwitter at twitter.com/texaschildrens.

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CONFERENCE SPONSORS (Continued)

MEDIA SPONSORS:

Science Translational Medicine promoteshuman health by providing a forum forcommunicating the latest biomedical

research findings from translational researchers in allareas of medicine. The journal strives to bridge the gapbetween the rich foundation of basic science and theneeds of clinical medicine, facilitating informationexchange in both directions. http://stm.sciencemag.org/

The International Journal of Artificial Organs(IJAO) is the Official Journal of the EuropeanSociety for Artificial Organs. IJAO publishesmonthly peer-reviewed research, clinical andexperimental contributions to the fields of

artificial, bioartificial and tissue-engineered organs.IJAO’s mission is to foster the development of artificial,

bioartificial, tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of allhuman tissues and organs. www.artificial-organs.com

IOP Publishing is an international, not-for-profit,

learned society publisher. We are a world leader in scientific publishing and the electronic dissemination of peer-reviewed scientific research. Stop by our table for a sample copy of one of our renowned journals, such asBiomedical Materials (www.iopscience.iop.org/bmm)and Biofabrication (www.iopscience.iop.org/bf).

Tissue Engineering is the premier biomedical journal

merging engineering and life sciences for tissue development. Part A provides fundamental research andunderstanding of structure-function relationships. Part B,Reviews publishes critical discussion and analyses toassess progression in the field. Part C Methods presentsprocedures and protocols to translate research into future clinical applications. www.liebertpub.com/products/product.aspx?pid=315

Stem Cell Research & Therapy is aninternational peer-reviewed journal

publishing open access research articles of outstandingquality with a special emphasis on basic, translational,and clinical research into stem cell therapeutics. Edited by Rocky Tuan and Timothy O’Brien, the journal’s firstImpact Factor is due in 2012. http://stemcellres.com

Wiley-Blackwell is theinternational scientific,

technical, medical and scholarly publishing business ofJohn Wiley & Sons, with strengths in every major academic and professional field and partnerships withmany of the world’s leading societies. For more information, please visit www.wileyblackwell.comor http://onlinelibrary.wiley.com/

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EXHIBITORS

AABB is a leading cellular therapy (CT)organization with 60+ years of experienceproviding professional development, standard setting and accreditation.

Expand your professional network and experiencethrough participation in the rapidly growing CT Sectionincluding a group for novel therapies and product development. AABB members can now add theRegenerative Medicine journal to their benefits. Research grants available up to $75,000.http://www.aabb.org

AFIRM is a multi-institutional, interdisciplinary network working to

develop advanced treatment options for our severelywounded Warriors. AFIRM is designed to speed the delivery of regenerative medicine therapies to treat ourmost severely injured Warriors from around the world, in particular those supporting operations in Iraq andAfghanistan. www.afirm.mil

Biomomentum specializes in providingsolutions for the biomechanical

evaluation of biomaterials and cartilage. It develops andcommercializes: Arthro-BST, an arthroscopic probe developed for precise non-destructive assessment of articular cartilage, which calculates a quantitativeparameter reflecting its biochemical composition andload-bearing properties; and Mach-1, a micromechanicaltester capable of performing compression, tension, shearand torsion tests for precise characterization and mechanical stimulation of cartilage and other soft tissueor materials. Biomomentum also offers biomechanicaltesting services using its unique instrumentation.www.biomomentum.com

BioSpherix will be exhibiting the XvivoSystem, world’s first and only barrier isolator optimizedfor cells. Economical and practical alternative to cleanrooms for cGMP compliant production of humancells for clinical use. Get better contamination control,better process control, better quality control, better pocketbook control. Stop by the BioSpherix booth.http://www.biospherix.com/

Bose Corporation manufactures the ElectroForce® test instruments

using proprietary linear motor technology. Bose offersinstruments for the characterization of soft tissues, biomaterials, bones and a variety of medical devicesincluding stents, endovascular grafts, and spinal implants.The BioDynamicTM test instruments provide characteriza-tion and stimulation of tissue constructs in a biologicalenvironment. www.bose-electroforce.com

Celgene is a global biopharmaceutical company committed to delivering truly innovative and life-changing therapies to

patients. The Cellular Therapeutics Division of Celgene is committed to the discovery, development and commercialization of novel human cell and tissue basedtherapeutic products for the treatment of severe anddebilitating diseases. http://www.celgene.com/

CellGenix has been a worldwideleader with the highest quality ex vivo

reagents available for clinical cellular therapies for over16 years. CellGenix manufactures both high quality GMPand research grade cytokines and GMP cell culture medium for use in ex-vivo dendritic, stem, NK, MSC, and T cell culture protocols. CellGenix’s focus is on highquality, individualized, ex-vivo, cell and gene therapeutics. Our continued mission to provide improvedproducts and processes that enables patients to livelonger lives. www.cellgenix.com

Crescent Chemical Company is theUS distributor for Serva Collagenase

NB6 GMP which has been optimized for isolation andpassaging of cells designated for transplantation intohumans. It is sterile and ready for immediate use, meetsstringent safety standards such as TSE safety certificationand very low endotoxin levels.www.crescentchemical.com

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DaVINCI Biomedical Research is a preclinical CRO specializing in regenerativeapplications performing GLP & Non-GLP

animal studies for FDA approval. We provide expertise inanimal models for scaffold applications (organ, vessel,tendon, muscle), wound, orthopeadic (bone, joint, cranial, maxillofacial, spine), cardiovascular (valve, MI,CHF, vessel/artery), and much more. Our services includehigh level surgical skills, mechanical engineering & testing via Instron System, imaging, and a large array ofanimal models (Non-human primates, canine, porcine,ovine, caprine, bovine, and rodents). Check out our newwebsite at www.davincibiomed.com.

Elsevier Science & Technology Books has provided award-winning education resources to researchers worldwide and is pleased topublish Principles of Regenerative Medicine,

2nd edition, by Atala, Lanza, Thomson and Nerem. It isthe first book of its kind to offer an advanced understand-ing of the latest technologies in regenerative medicine.http://www.elsevierdirect.com/stemcells

IEEE Engineering in Medicine and Biology Society (EMBS) is the world’s largest international society of biomedical engineers. EMBS members are focused on the development and application of engineering conceptsand methods to provide new solutions to biological, medical and health care problems. http://embs.org/

Fisher BioServices (FBS), a unit of Thermo FisherScientific, is a professional cell therapy services businessoperating under GMP and GTP guidelines. With locationsaround the world, FBS is committed to providingbiorepository, logistics infrastructure and clinical trialservices to the cell therapy industry. Our global facilitiesand capabilities provide integrated solutions from collection site or CMO to repository or clinical site.Services include biorepository, biobanking, laboratoryservices, cell or specimen collection kits and distribution,cold chain and ultra cold chain management.www.fisherbioservices.com

EXHIBITORS (Continued)

Glycosan BioSystems’ cGMP-quality hydrogels connectcell culture with cell therapy. The

hydrogels (HyStem) are made from naturally occurringhyaluronan. They are also customizable and injectable,providing a lifelike cellular microenvironment for neuraland orthopedic applications. www.glycosan.com

Harvest manufactures the first-of-its-kind SmartPReP 2 Cell ConcentrationSystem with BMAC (Bone Marrow

Aspirate Concentrate) procedure packs for ConcentratingAutologous Adult Stem Cells, and APC+ procedure packsfor Concentrating Platelets—both at point-of-care in only15 minutes, and both with small volume 30mL kits nowavailable. In minutes, SmartPReP produces predictableconcentrates enriched with multiple cells and GrowthFactors. www.harvesttech.com

IOP Publishing is an interna-tional, not-for-profit, learned

society publisher. We are a world leader in scientific publishing and the electronic dissemination of peer-reviewed scientific research. Stop by our table for asample copy of one of our renowned journals, such asBiomedical Materials (www.iopscience.iop.org/bmm)and Biofabrication (www.iopscience.iop.org/bf).

JMS Co., Ltd., one of the largest Japanese medical device companies, is

presenting CELLAID® a new medical device for serumcollection. CELLAID® is specially designed to preparegrowth-factor-rich human serum within 1 hr. We will also display biodegradable films, tubing and spongesprocessed from our in-house made P(LA/CL) copolymer.www.jms.cc/english/index.html

Kaneka Corporation is a producer of chemical products including resins,

pharmaceutical intermediaries, food supplements, synthetic fibers, and fine chemicals. The Innovate Bone Marrow MSC separation device harvests mesenchymal stem cell (MSC) via a filter.http://kaneka-cellseparation.jp/msc/english

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Lifecore Biomedical, LLC, specializesin aseptic filling and manufacturing of hyaluronan by fermentation and

recently introduced CorgelTM BioHydrogel kits to theresearch community. Hyaluronan is used and Corgel is being evaluated in applications that range from ophthalmology and tissue engineering to orthopedics,wound healing and aesthetics, along with several others.www.lifecore.com

The McGowan Institutefor Regenerative

Medicine, part of the University of Pittsburgh and UPMC,serves as a base for scientists and clinical faculty workingin tissue engineering and biomaterials, cellular therapies,and medical devices and artificial organs. McGowan’smission is the development of innovative clinical proto-cols and the commercial transfer of new technologies.www.mcgowan.pitt.edu

Nano3D Biosciences, Inc. (n3D) seeks tocreate the industry leading standard for 3-dimensional cell culturing solutions. Using

a proprietary combination of nanoparticle-based reagentsand magnetic fields, n3D created a simple device to magnetically levitate cells to enable 3-dimensional tissuegrowth. n3D’s “Bio-Assembler” succeeds in offering an in vitro device that mimics the in vivo environment withmany major advantages over existing cell culturing methods. This breakthrough technology will directlyaddress core needs in life sciences, drug discovery,toxicology, and regenerative medicine. www.n3dbio.com

NovaMatrix, a business unit of FMCBioPolymer, provides well-character-ized, ultrapure alginate, water-

soluble chitosan salts and hyaluronic acid for use in drug delivery, tissue engineering, cell encapsulation, and medical device applications where functionality and regulatory documentation are important. Our newNovaMatrix 3-D cell culture system expands researchpossibilities in regenerative medicine.www.novamatrix.biz


Organovo is a regenerativemedicine company focused on

delivering breakthrough three dimensional biology capabilities to create tissue on demand for research andsurgical applications. The NovoGen MMX Bioprinter is at the forefront of sculpting three dimensional and functional tissue consisting of multiple cell types and biomaterials. Visit us at www.organovo.com.

Using our proprietary expertise inmicromachining and knitting, Proxy

Biomedical designs, develops, and manufactures industryleading absorbable and non-absorbable tissue engineering biomaterials and delivery systems. The product platforms combine minimally invasive surgerytechniques with optimal tissue regeneration. Advancedbiomaterials, tissue engineering scaffolds, medical textilesand delivery systems produced with state-of-the-art materials and processes will be on display.www.proxybiomedical.com

RESBIO is an NIH-funded national biomedical technology resource thatdevelops integrated multidisciplinary state-of-the-art technologies tailored to

accelerate biomaterials research. The booth will showcasehigh-throughput polymeric biomaterial synthesis, high-throughput cell-material interaction characterization,mechanobiology research, confocal microscopy for earlydetermination of stem cell lineage commitment, andcomputational modeling for biomaterial optimization.http://www.njbiomaterials.org/web/index.php?p=resbio

SANYO Biomedical Solutions is a global, leading provider of energy,environment, and lifestyle applications

with laboratory equipment for pharmaceutical, life science and biotechnology applications. Product linesinclude space-efficient VIP® ultra-low temperature freezers, cryogenic freezers, pharmaceutical and medicalrefrigerators, cell culture incubators, plant growth chambers, and portable autoclave. For the GMP compliant processing and manufacturing of tissue and cell therapies, SANYO Biomedical Solutions offers the innovative Cell Processing Work Station.www.sanyobiomedical.com

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Synthecon Inc. provides cellculture solutions to researchers

involved in tissue engineering, stem cell research, matrixdevelopment, 3D cell culture, and tissue modeling fordrug discovery or infectious disease studies. The RotaryCell Culture SystemTM (RCCS) platform technologyaffords a unique gentle environment for the growth andexpansion of cells in a 3D architecture. Additionally theRCCS allows for the co-culture of multiple cell typeswhich assemble into three-dimensional tissue models.www.synthecon.com

Nanofibre Scaffolds for 3D Cell Culture andRegenerative Medicine - from bench to bedsideWe manufacture reproducible electrospun scaffolds for laboratory use and partner with our customers todevelop cell-based implantable devices for regenerativemedicine. Our scaffolds are made from FDA approvedpolymers to facilitate translation from lab to clinic.www.electrospinning.co.uk

ThermoGenesis® developsand manufactures

innovative and enabling technologies for Stem CellProcessing and Cryopreservation. —- Res-QTM60 BMCpoint-of-care system- concentrates bone marrow in 15minutes. —-BioArchive® System- fully robotic system for cryo-preservation and archiving of stem cells. —-AutoXpressTM product platform- isolates and concentrates stem cells from bone marrow aspirate or cord blood. www.thermogenesis.com


Tissue Growth Technologies, aleading supplier of bioreactors formechanically-stimulated 3D tissue

growth, offers products ranging from modular componentsto fully integrated systems. Chambers impart computercontrolled mechanical forces to developing tissues in a real-time monitored, incubator friendly, sterile environment. TGT products allow researchers to designexperiments, not instruments. www.tissuegrowth.com

Veterinary Transplant Services, Inc. (VTS) provides custom animal tissue procurement and processing for pre-clinical trials, R&D, product testing, and more.Working with a professional animal tissue bank for youranimal tissue needs will provide you with clinical-qualityanimal tissue. Only tissue graft that has been processedaccording to current Good Tissue Practices (cGTP) and tissue banking industry standards provides the level ofconsistency and predictability of tissue graft used in aclinical setting. Working with animal tissue that has notbeen processed to tissue banking industry standards mayweaken or jeopardize your pre-clinical trials, R&D,or product testing outcomes. www.vtsonline.com

The Wake Forest Institute for Regenerative Medicine’smission is to improve patients’ lives through regenerativemedicine therapies. Its scientists engineered the first laboratory-grown organs to be implanted into humans.The team currently is working to engineer more than 30different organs and tissues and to develop cell therapiesto restore organ function.http://www.wakehealth.edu/wfirm/

TABLE-TOP EXHIBIT DISPLAYS:

Tissue Engineering is the premier biomedical journal merging engineering and life sciencesfor tissue development. Part A provides fundamental research and understanding of

structure-function relationships. Part B, Reviews publishes critical discussion and analyses to assess progression in thefield. Part C Methods presents procedures and protocols to translate research into future clinical applications.www.liebertpub.com/products/product.aspx?pid=315

Wiley-Blackwell is the international scientific, technical, medical and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and

professional field and partnerships with many of the world’s leading societies. For more information, please visit www.wileyblackwell.com or http://onlinelibrary.wiley.com/

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EXHIBITORS FLOOR PLAN AND BOOTH LOCATION

AABB: 203AFIRM: 702Biomomentum: 406BioSpherix: 207Bose: 302Celgene: 303CellGenix: 507Crescent Chemicals: 501DaVINCI Biomedical Research Products: 306Elsevier: 407Fisher BioServices: 301Glycosan Biosystems: 101Harvest Technologies Corp: 500IEEE Engineering in Medicine & Biology Society: 403IOP Publishing: 307JMS: 200

Kaneka: 201Lifecore Biomedical: 506McGowan Institute for Regenerative Medicine: 603n3D Biosciences: 502NovaMatrix: 400Organovo: 300Proxy Biomedical: 103RESBIO - NIH Funded Biomedical Technology

Resource: 503SANYO: 606Synthecon: 402The Electrospinning Co: 600ThermoGenesis Corp: 401Tissue Growth Technologies: 202Veterinary Transplant Services: 107WFIRM: 700

OPENING RECEPTIONSunday, December 11, 2011 • 6:30 - 9:00 pm • Located in the Exhibit Hall in the Grand Ballroom

Each attendee is required to check-in at the 2011 TERMIS NA Conference registration desk.Photo ID is required at check-in. The registration desk will be open at the following times:

Sunday, December 11 from 7:00am - 7:00pm • Monday, December 12 from 7:00am - 5:00pmTuesday, December 13 from 7:00am - 5:00pm • Wednesday, December 14 from 7:00am – Noon

Exhibit hours / Poster viewing hours:Sunday, December 11, 2011 6:30 PM - 9:00 PM - Welcome reception held in the Exhibit Hall

Monday, December 12, 2011 9:30 AM - 10:00 AM • 11:30 AM - 1:00 PM • 2:30 PM - 3:00 PM • 4:30 PM - 6:00 PM Tuesday, December 13, 2011 9:30 AM - 10:00 AM • 11:30 AM - 1:00 PM • 2:30 PM - 3:00 PM • 4:30 PM - 6:00 PM

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