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Transcript of P R O G R A M - TERMIS
P R O G R A MThe TERMIS
North America 2011Annual Conference
& ExpositionDecember 11-14, 2011
Hilton Americas-Houston • Houston, Texas
1
Welcome… 2
General Information… 3
PRECONFERENCE WORKSHOP“Advances in Tissue Engineering for
Pediatric Applications”… 4-5
PRECONFERENCE WORKSHOPCells, Gels and Alginate - An Alginate Technology
Tutorial… 6
POST-CONFERENCE WORKSHOPRegenerative Medicine’s Challenge to Cure… 7-8
Agenda… 9-11
POSTER SESSION I,Monday, December 12, 2011… 12-15
POSTER SESSION II,Tuesday, December 13, 2011… 16-19
Student and Young Investigator Activities… 20-23
TERMIS NA Awards… 24-25
Sponsors… 26-28
Exhibitors… 29-32
Exhibitor Floor Plan and Booth Location… 33
TABLE of CONTENTSOPENING RECEPTION
Sunday, December 11, 2011 • 6:30 - 9:00 pm Located in the Exhibit Hall in the Grand Ballroom
Each attendee is required to check-in at the 2011 TERMIS NA Conference registration desk.
Photo ID is required at check-in.
WELCOME LETTER
December, 2011
Dear Fellow TERMIS Members and Guests:
On behalf of the TERMIS-NA, the scientific organizers, Dr. Jennifer West and Dr. Jane Grande-Allen, the scientific advisory board, and everyone involved in supporting the TERMIS-NA 2011 Conference and Expo, I would like to personally welcome you to Houston, Texas, and thank you for joining us!
The TERMIS-NA Annual Conference and Expo has now become the major venue for the presentation of basic tissueengineering and regenerative medicine research, and its clinical application. Our goal for this successful meeting is to continue to foster interactions among scientists engaged in discovery and development, translational researchers who bring scientific discoveries to the clinical forefront, and those engaged with funding, regulatory and commercial developments.
The main theme of this year’s meeting is “Scaffolds in Tissue Engineering: Bridging Matrix Biology and BiomaterialsScience.” The scientific co-organizers and advisory committee has put together an exceptional scientific program, which covers a wide range of topics with the field of tissue engineering, biomaterials, stem cells and regenerativemedicine. This year, we are pleased and excited to welcome our keynote lecturers: Kristi S. Anseth, Ph.D., Distinguished Professor, University of Colorado, Christopher S. Chen, M.D., Ph.D., Skirkanich Professor of Innovation in Bioengineering, University of Pennsylvania and Molly S. Shoichet, Ph.D., Professor of Chemical Engineering &Applied Chemistry, Chemistry and Biomaterials & Biomedical Engineering, University of Toronto.
These keynote lectures, together with presentations from invited experts and presentations from junior and new investigators, and the conference agenda, offer new insights from leading experts in our respected field. Altogether, theconference has 188 oral presentations, 302 poster presentations, and almost 40 sponsors and exhibitors. The numbersreflect the huge potential we have as a community as we continue our pursuit of excellence in our respective fields.
International and U.S.-based guests include a good mix of academicians, corporate professionals, and government representatives, with CEOs, principal investigators, post-doctoral fellows, pre-doctoral students, and other researchers.The conference provides a superb setting for networking, exchange and continued collaborations.
The Student and Young Investigator Section of North America (SYIS-NA) has again organized a number of excitingactivities at the meeting, specifically for newer investigators. The role of SYIS is to assist and encourage youngresearchers to network and interact with experts in the field and to foster personal professional development. Please see the SYIS-NA schedule of events in the program book or on meeting website (http://www.termis.org/na2011).
New full -day workshops include: Tissue Engineering for Pediatric Applications on Sunday, December 11 and“Regenerative Medicine’s Challenge to Cure” on Wednesday, December 14. A new tutorial featuring alginate technology will also be presented on Sunday. We are confident that you will benefit from these additional educationalprograms. On-site registration is an option pending space availability.
We are so very proud of TERMIS-NA and the progress this meeting has fostered for the tissue engineering and regenerative medicine community. This meeting is a gathering of the best research minds, all sharing our respectivepassion and pride in making strides in our research areas.
I encourage you to celebrate this week with us as we enjoy another stellar scientific program!
Sincerely,
Antonios G. Mikos, Ph.D., Conference Co-ChairLouis Calder Professor of Bioengineering, Chemical and Biomolecular EngineeringDirector, Center for Excellence in Tissue EngineeringDirector, J.W. Cox Laboratory for Biomedical EngineeringRice University
2
GENERAL INFORMATION
SCIENTIFIC ADVISORY COMMITTEE
Jennifer West, Ph.D., Co-Organizer, Rice UniversityJane Grande-Allen, Ph.D., Co-Organizer, Rice University Anthony Atala, M.D., Wake Forest Institute for Regenerative MedicineJulia Babensee, Ph.D., Georgia Institute of TechnologyMalcolm Brenner, M.D., Ph.D., Baylor College of MedicineMary Dickinson, Ph.D., Baylor College of MedicineRobert Guldberg, Ph.D., Georgia Institute of TechnologyFarshid Guilak, Ph.D., Duke University Medical CenterKevin Healy, Ph.D., Univ of California, BerkeleyBrenda Mann, Ph.D., SentrXTodd McAllister, Ph.D., Cytograft Tissue EngineeringMichael Sefton, Ph.D., University of TorontoJames Yoo, M.D., Ph.D., Wake Forest Institute for Regenerative Medicine
ONSITE REGISTRATION AND CONFERENCE CHECK-IN
Photo ID is required at check-in. The registration desk will be open at thefollowing times:
• Sunday, December 11 from 7 am – 7 pm• Monday, December 12 from 7 am – 5 pm• Tuesday, December 13 from 7 am – 5 pm• Wednesday, December 14 from 7 am – 5 pm
Opening Reception
• Sunday, December 11, 2011• 6:30 – 9 pm• Lanier Grand Ballroom (Fourth Floor)
DISCLAIMERThe material presented at the TERMIS-NA 2011 Conference has been made available by theTissue Engineering and Regenerative Medicine International Society (TERMIS) for educationalpurposes only. The material is not intended to represent the only, nor necessarily best, methodor procedure appropriate for the medical situations discussed, but rather is intended to presentan approach, view, statement or opinion of the faculty which may be helpful to others whoface similar situations. Tissue Engineering and Regenerative Medicine International Society(TERMIS) disclaims any and all liability for injury or other damages resulting to any individualattending the meeting and for all claims which may arise out of the use of the techniquesdemonstrated therein by such individuals, whether these claims shall be asserted by physicianor any other person.
NOTICENo part of this publication may be translated or reproduced, in any form or by any means,without written permission from TERMIS- NA. No photography, video, audio recording orreproduction of any kind may be used during any portion of the TERMIS- NA 2011Conference. TERMIS NA reserves all of its rights to such materials, and commercial recordingor reproduction is specifically prohibited. This includes, but is not limited to, digital and filmphotography, videography, cellular phones, and other image or audio recording devices.
C O N G R A T U L A T I O N STO THE TERMIS-NA 2011
CONFERENCE AND EXPOSITION PLANNING TEAM
Antonios G. Mikos, Ph.D.Conference Co-Chair, Rice University
Jennifer L. West, Ph.D.Conference Co-Chair and Scientific Program Co-Chair, Rice University
K. Jane Grande-Allen, Ph.D.Scientific Program Co-Chair, Rice University
F. Kurtis Kasper, Ph.D.Local Arrangements Chair, Rice University
Executive Production Provided byForecast Technology Group
www.conferencestrategists.comAnita Caufield, MHA
Andrea Lubienski, CMPGina Saxton
Conference Liaison for TERMISSarah Wilburn
TERMIS-NA TreasurerBill Tawil
Special thanks to K. Jane Grande-Allen, Ph.D.Associate Professor, Rice University andJeffrey Jacot, Ph.D., Assistant Professor,
Texas Children's Hospital / Rice University fororganizing the Advances in Tissue Engineering
for Pediatric Applications Workshopand to
Mark E. K. Wong, DDS, Chairman and Program Director, Department of Oral and
Maxillofacial Surgery, The University of Texas School of Dentistry at Houston
for organizing the Regenerative Medicine'sChallenge to Cure Workshop.
3
AUDIENCETissue engineers,
physicians (surgeons, cardiologists, obstetricians, neurologists, urologists),
research scientists, biomedical engineers and a range
of other experts and collaborative partners
WORKSHOP CO-CHAIRSK. Jane Grande-Allen, Ph.D.,
Associate Professor, Rice University
Jeffrey Jacot, Ph.D.,Assistant Professor, Texas Children’s
Hospital / Rice University
PRECONFERENCE WORKSHOP • SUNDAY, December 11, 2001
The promise regenerative medicine holds for curing a wide range of diseasesis a driving force behind many nationally recognized research teams. Whentargeting pediatric illnesses, landmark discoveries and breakthroughs especially offer renewed hope for children and families.
The ultimate goal is to someday transform kids’ lives who are suffering fromdevastating illnesses and birth defects, including muscular dystrophy, heartdisease, cleft palates, and kidney failure. Today, many investigators in thefield of tissue engineering cite congenital defects and the need to develop tissues that can grow as compelling justification for their research. However,pediatric applications actually represent a surprisingly small fraction ofresearch presented and published in the tissue engineering field.
This forum offers the opportunity to bring together disease-specific teams,comprised of researchers and clinicians exploring the most promisingapproaches. We are optimistic that by sharing our respective knowledge, we will be able to:
• Draw attention to the specific tissue engineering and regenerative medicineneeds of prenatal, neonatal, and pediatric patients;
• Clarify how needs for pediatric patients differ from the needs of adult patients;
• Inform all clinicians (including non-pediatric) about this research, especially those new to TERMIS-NA;
• Enhance collaboration and initiate discussions between pediatric clinicians and tissue engineering researchers; and
• Provide a platform to highlight the research of young investigators in the field of pediatric tissue engineering and regenerative medicine.
This forum will feature presentations describing research investigations onpediatric tissue engineering applications, including but not limited to: cardiovascular, orthopedic, maxillofacial, gastrointestinal, and urologicaldiscoveries. We will feature a program of invited speakers at various academic ranks from clinical and basic research institutions, with a specialemphasis on young investigators.
AGENDA
8:00 AM Registration and continental breakfast
9:00 AM Welcome and Introductory LectureCharles Fraser, M.D., Surgeon-in-Chief, Texas Children’s HospitalUrgent Need for Greater Focus on Pediatric Tissue Engineering
9:30 AM Keynote Lecture 1Hesham Sadek, M.D., Ph.D.Assistant Professor, Dept. of Cardiology, UT-SouthwesternRegeneration of Neonatal Hearts
“ADVANCES IN
TISSUE ENGINEERINGFOR
PEDIATRICAPPLICATIONS”
December 11, 2011 8:00am - 6:00pm
(Continued on following page)
4
Derrick Wan, M.D.Assistant Professor, Plastic Surgery,
Stanford UniversityCraniofacial tissue engineering
James Yoo, M.D., Ph.D.Professor, Wake Forest Univ. Institute of
Regenerative MedicinePediatric genitourinary tissue engineering
3:00 PM Coffee Break
3:30 PM Keynote Lecture 3Alan Flake, M.D.Professor, University of Pennsylvania,
Pediatric SurgeryPrenatal corrections of fetal anomalies using
tissue engineering
4:30 PM Session 3: Tissue Engineering for Fetal/Neonatal Interventions
Presentations and Panel Discussion
Jun Liao, Ph.D.Asst. Prof., Mississippi State Univ.,
Biological EngineeringAmnion as a tissue engineering scaffold
David Morales, M.D.Associate Professor, Congenital Heart
Surgery, Texas Children’s HospitalSmall intestinal submucosa patches for
congenital heart defect reconstruction
Jeffrey G. Jacot, Ph.D.Assistant Professor, Congenital Heart Surgery,
Texas Children’s Hospital and Bioengineering, Rice University
Tissue engineering contractile patches and tubes for congenital heart defects
Jane Grande-Allen, Ph.D.Associate Professor of Bioengineering,
Rice UniversityDefining design goals and biomaterials for
pediatric tissue engineered heart valves
5:30 PM Concluding RemarksSpeaker to be identified
6:00 PM Reception
10:30 AM Session 1: Tissue Engineering for Pediatric Cardiovascular ApplicationsOral Presentations and Panel DiscussionChristopher Breuer, M.D.Assoc. Professor of Surgery (Pediatrics),
Yale-New Haven Children’s HospitalTissue engineering blood vessels for
pediatric surgery
Anita Driessen-Mol, Ph.D.Asst. Prof. of Biomedical Engineering,
Eindhoven University of TechnologyHeart valve tissue engineering for neonates
Jonathan Butcher, Ph.D.Assistant Professor of Biomedical
Engineering, Cornell UniversityMechanobiology of embryonic heart tissue
Daniel Teitelbaum, M.D.Professor, University of Michigan,
Department of SurgeryPediatric gastrointestinal tissue engineering
11:30 AM Lunch
1:00 PM Keynote Lecture 2Dario Fauza, M.D.Associate Professor of Surgery,
Children’s Hospital BostonTissue engineering of pediatric diaphragmatic
tendon, spine, and trachea
2:00 PM Session 2: Tissue Engineering for Pediatric Musculoskeletal and Urologic Applications
Oral Presentations and Panel Discussion
Laura Perin, Ph.D.Asst. Professor, Dept. of Urology,
USC / Children’s Hospital of Los AngelesAmniotic fluid derived stem cells for tissue
engineering of kidneys
Yong Li, Ph.D.Assistant Professor, University of Pittsburgh,
Stem Cell Research CenterUse of muscle stem cells for skeletal muscle
repair of DMD kids: Progress and Challenge
PRECONFERENCE WORKSHOP • SUNDAY, December 11, 2001
(AGENDA Continued from previous page)
5
PRECONFERENCE WORKSHOP • SUNDAY, December 11, 2001
Alginate is a unique biopolymer that can be used to immobilize, entrap orencapsulate living cells by the instantaneous formation of an ionic cross-linked gel at physiological pH and temperature when an alginate solution comes into contact with calcium ions. This technology has beenused in the creation of cell therapy constructs such as encapsulated pancreatic islets. The alginate bead or capsule represents a biocompatiblebarrier between the immobilized cells and the body’s immune system. While the alginate bead system may be useful in several cell therapysituations, there is a need for larger constructs or shaping of injectable alginate gel structures. A second construct makes use of an injectable alginate solution that gels in situ. This “all-alginate” system of delayed gelling enables the formulation to be injected or implanted into tissue andirregular cavities before gelling. Thirdly, flexible alginate-based foams withadjustable structural integrity and biodegradation profiles have been developed as a matrix for culturing cells in 3D. The workshop will includethree “hands-on” stations where participants can make gels and immobilizematerials in alginate matrices.
PODIUM PRESENTATIONS(approximately 2.5 hours):
Introduction and purpose of the workshop (FMC presenter)
Experience with islet encapsulation for treating Type 1 diabetes (Invited presenter - Dr. Collin Weber, Emory University)
Development of Algisyl-LVR - an alginate-based medical device under clinical to prevent and reverse the progression of congestive heart failure -(Invited presenter - Mr. Frank Ahmann, LoneStar Heart)
Culturing cells in 3D in alginate foams - the importance of 3D culture in breast studies (Invited presenter - Dr. Simon Langdon, University of Edinburgh, UK)
Introduction to hands-on workshop - what we want to accomplish (FMC presenter)
HANDS-ON WORKSHOP (Workshop participants will be divided between three separate stations with rotation between stations) (approximately 2 hours):
Gelation - making macrobeads and microcapsules. Demonstration of calciumcross-linking of alginate and making macrobeads. Using an electrostatic beadgenerator for cell encapsulation and producing microbeads.
Self-gelling alginate - demonstration of an all-alginate, delayed gelling,injectable system.
Alginate matrix for 3D cell culture - demonstration of an alginate-basedmatrix for 3D cell culture. How to immobilize cells and how to recover cellular structures intact from foam matrix. Alginate foams as tissue engineering scaffolds.
CELLS, GELS AND ALGINATE -
AN ALGINATETECHNOLOGY
TUTORIAL
Sunday, December 111:00 - 5:00pm
OBJECTIVES:Participants should be able to understand the principles
of alginate and ionic gelation as well as potential applications
of alginate in various tissue engineering and regenerative
medicine applications. Participants will have made gels
as well as performed basic gelling and de-gelling examples. The workshop is intended
to give participants a working knowledge of this
biopolymer and to have experiencedsome of the alginate-based
technologies relevant to tissue engineering
and regenerative medicine.
6
A new one-day symposium, designed to introduce and showcase the excitingpotential offered by the regenerative medicine research community.
Are you aware of the enabling technologies that are now available for thepracticing clinician?
This first of its kind, interactive symposium will serve as a dynamicopportunity to better understand opportunities for patient treatment within thegrowing field of tissue engineering and regenerative medicine. The forum willclose the TERMIS-NA 2011 Conference and Expo, and will provide a uniqueopportunity to participate in a non-structured setting. Experts will discuss how regenerative medicine is poised to change the landscape of modernmedicine. You’ll interact with global experts who have come to Houston forthe TERMIS-North America 2011 annual conference and recognized leaderswho are willing to share their knowledge and project insight.
ApproachResearch => Clinical Trials => Regulatory Pathways =>
Funding => Commercialization
By presenting the clinical pathways and challenges for some of the most disabling and debilitating diseases and injuries, researchers will offer in-depthdiscussions on the latest therapies available for several of the world’s mostproblematic diseases and injuries. They’ll also address therapies which offerthe most promise for near-term cures. Presenters will candidly describe thechallenges they have faced in discovering cures or treatments.
Each clinician will present the cause, the symptoms, the current treatment options and the results of a particular disease or injury. They will then lead a discussion with an audience of scientists, engineers, clinicians, biologists and others on the potential solutions to the challengesbeing presented.
Clinical translation including regulatory affairs, translational processes,funding and industry will be highlighted.
Focus areas include: Bone • Cartilage • Neural Tissue
By sharing our knowledge, you will be able to:• Identify the challenges you and your colleagues face on a daily basis,
and provide the latest therapy approaches in regenerative medicine and tissue engineering
• Discuss the obstacles encountered in clinical translation (funding, regulatory issues, etc) and ways to best overcome these issues.
• Come away with a clear understanding of the solutions that havebeen investigated to date, and how far have they come
• Participate with global experts who are specialists in orthopedics, neurology, rehab medicine
• Find out how close this industry is to discovering new applications for life-enhancing technologies
• Specific questions that will be discussed include: • What are the unmet clinical needs and opportunities for tissue engineering
and regenerative medicine therapies?• What are specific translational pathways for engineered tissues and
regenerative medicine therapies that could lead to clinical trial and therapeutic development?
• What are the practical clinician-based approaches, e.g. isolating cells for transplantation in a given office vs. having off-the-shelf products?
POST-CONFERENCE WORKSHOP • WEDNESDAY, December 14, 2011
REGENERATIVEMEDICINE’S CHALLENGE
TO CURE
December 14, 2011 9:15am - 4:00pm
AUDIENCEAll tissue engineering researchers
(scientists, bioengineers, clinicians) who have an interest in translational
research, moving basic researchtoward applications, and assessing
the efficacy and effectiveness of potential new treatments.
This is a must-attend symposium for any clinician involved in and will be of most value if you are a clinician,
medical student, resident, particularlyfrom orthotics orthopedics, neurologyneurosurgery, oral and maxillofacial surgery, plastic and reconstructive
surgery, otorhinolarygology,academia, industry, government and others experts who are involved in
translating scientific discovery into patient treatments.
WORKSHOP ORGANIZERMark E. K. Wong, DDS,
Chairman and Program Director,Department of Oral and Maxillofacial Surgery,
The University of Texas School of Dentistry at Houston
(Continued on following page)
7
POST-CONFERENCE WORKSHOP • WEDNESDAY, December 14, 2011
AGENDA
9:15 - 9:20 AM Welcome RemarksMark E. Wong, D.D.S., The University of Texas Health Science Center at Houston
9:20 - 10:00 AM Clinical Challenges in the BattlefieldJoseph C. Wenke, Ph.D., United States Army Institute of Surgical Research
10:00 - 10:40 AM Promise and Pitfalls of Tissue Engineering Circa 2011F. Kurtis Kasper, Ph.D., Rice University
10:40 - 11:20 AM Advances in Cartilage RegenerationJennifer H. Elisseeff, Ph.D., Johns Hopkins University
11:20 - 12:00 AM Cartilage Degeneration and its Impact on SocietyTerry A. Clyburn, M.D., The University of Texas Health Science Center at Houston
12:00 - 13:00 PM LUNCH
13:00 - 13:40 PM Meeting the Challenges in Nerve RegenerationMichael J. Yaszemski, M.D., Ph.D., Mayo Clinic College of Medicine
13:40 - 14:20 PM A Shortage of BoneMichael J. Miller, M.D., The Ohio State University
14:20 - 14:35 PM BREAK
14:35 - 15:15 PM Current and Future Strategies to Regenerate BoneRobert E. Guldberg, Ph.D., Georgia Institute of Technology
15:15 - 15:55 PM From Bench to Clinic: A Long and Winding RoadAnthony Ratcliffe, Ph.D., Synthasome, Inc.
15:55 - 16:00 PM Concluding RemarksMark E. Wong, D.D.S., The University of Texas Health Science Center at Houston
8
8 am - 6 pm Advances in Tissue Engineering for Pediatric ApplicationsGrand Ballroom BC
1 - 5 pm Cells, Gels and Alginate - An Alginate Technology TutorialGrand Ballroom EF
6:30 - 9 pm Opening ReceptionGrand Ballroom ADGJ
S U N DAY • D e c e m b e r 1 1 , 2 0 1 1
M O N DAY • December 12, 2011
8 - 8:05 am Welcome Announcements • Grand Ballroom
8:05 - 9 am Plenary Speaker I - Kristi Anseth - User Programmable Biomaterial Niches for 3D Cell Culture and Tissue Regeneration • Grand Ballroom
9 - 9:30 am Award Announcement and Presentation - TERMIS-NA Senior Scientist Award: David Mooney “Cancer Vaccines Based on Tissue Engineering Strategies” and Mary Ann Liebert, Inc. Outstanding Student Award: Jessica DeQuach “Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds” • Grand Ballroom
9:30 - 10 am Coffee Break with Poster Viewing • Grand Ballroom
10 - 11:30 am Immunology and InflammationGrand Ballroom BC
Neural Tissue EngineeringGrand Ballroom EF
Decellularized TissuesGrand Ballroom HI
Nanobiotechnology - EMBS Joint SessionGrand Ballroom KL
11:30 am - 1 pm Lunch Break with Poster Viewing • Grand Ballroom
1 - 2:30 pm Controlled Release in Regenerative MedicineGrand Ballroom BC
Stem Cell SourcesGrand Ballroom EF
Vascularization of Engineered TissuesGrand Ballroom HI
Imaging and Assessment of Engineered TissuesGrand Ballroom KL
2:30 - 3 pm Break with Poster Viewing • Grand Ballroom
3 - 4:30 pm Scaffold MaterialsGrand Ballroom BC
Cell Processing and Preservation-AABB Joint SessionGrand Ballroom EF
Skin and Wound HealingGrand Ballroom HI
AFIRM SessionGrand Ballroom KL
4:30 - 6 pm Exhibit Viewing and Reception • Grand Ballroom
Poster Session 1Grand Ballroom
9
8 - 8:05 am Announcements • Grand Ballroom
8:05 - 9 am Plenary Speaker II - Christopher Chen - Engineered Microenvironments: An Approach to Understand Cell Adhesion, Forces, and Assembly into Tissues • Grand Ballroom
9 - 9:30 am Award Announcement and Presentation - TERMIS-NA Young Investigator Award: Kurt Kasper and WFIRM Young Investigator Award Winners - Melissa Krebs and Brian Diekman • Grand Ballroom
9:30 - 10 am Coffee Break with Poster Viewing • Grand Ballroom
10 - 11:30 am Musculoskeletal SymposiumGrand Ballroom BC
Peripheral Nerve RegenerationGrand Ballroom EF
Hepatic and Endocrine Tissue EngineeringGrand Ballroom HI
Extracellular MatrixGrand Ballroom KL
11:30 am - 1 pm Lunch Break with Poster Viewing • Grand Ballroom
1 - 2:30 pm Musculoskeletal SymposiumGrand Ballroom BC
Mesenchymal Stem CellsGrand Ballroom EF
Cardiac Tissue EngineeringGrand Ballroom HI
Bioactive Scaffold MaterialsGrand Ballroom KL
2:30 - 3 pm Break with Poster Viewing • Grand Ballroom
3 - 4:30 pm Musculoskeletal SymposiumGrand Ballroom BC
Endogenous Stem Cell HomingGrand Ballroom EF
Scaffold FabricationGrand Ballroom HI
TERMIS-NA Industry Committee PanelGrand Ballroom KL
4:30 - 6 pm Exhibit Viewing and Reception • Grand Ballroom
Poster Session IIGrand Ballroom
T U E S DAY • December 13, 2011
10
8 - 8:05 am Announcements • Grand Ballroom
8:05 - 9 am Plenary Speaker III - Molly Shoichet - 3D Biomolecule Patterned Hydrogels Guide Cell Growth and Differentiation • Grand Ballroom
9 - 9:15 am Coffee Break • Grand Ballroom
9:15 - 10:30 am Injectable BiomaterialsGrand Ballroom BC
Urologic and Renal Tissue EngineeringGrand Ballroom EF
Vascular Tissue EngineeringGrand Ballroom HI
Clinical DayGrand Ballroom KL
10:30 - 11:45 am Bioreactor TechnologiesGrand Ballroom BC
CancerGrand Ballroom EF
Engineering Heart ValvesGrand Balllroom HI
Clinical DayGrand Ballroom KL
11:45 - 1:00 pm Lunch
1:00 - 2:30 pm Soft Tissue RepairGrand Ballroom BC
Mimicking Stem Cell NichesGrand Ballroom EF
Microfabrication and PrintingGrand Ballroom HI
Clinical DayGrand Ballroom KL
2:30 - 2:45 pm Break
2:45 - 4:15 pm Gene TherapyGrand Ballroom BC
Stem Cell Differentiation and CharacterizationGrand Ballroom EF
Manufacturing and CommercializationGrand Ballroom HI
Clinical DayGrand Ballroom KL
4:15 - 4:45 pm Award Announcement and Presentation - TERMIS-NA Lifetime Achievement Award: Robert Langer “Advances in Tissue Engineering” • Grand Ballroom
4:45 - 5:00 pm Closing Ceremony - World Congress 2012 - Congress President Heinz Redl and TERMIS-NA 2013 Conference Chair Robert Guldberg followed by the TERMIS-NAContinental Chair and 2011 TERMIS-NA Conference Co-Chair, Antonios MikosGrand Ballroom
5:00 pm Adjournment • Grand Ballroom
W E D N E S DAY • December 14, 2011
11
POSTER SESSION I • Monday, December 12, 2011
ASSESSING ENGINEERED TISSUES IN VITRO AND IN VIVO
1 0424 Eunna ChungEffective Tracking of Adipose Tissue-Derived StemCells Seeded in a PEGylated Fibrin Gel usingGold Nanotracers for Dermal/Vascular TissueEngineering Applications
2 0440 Marta Raquel FontanillaReal-time quantification of autologous artificialconnective tissue (AACT) secreted factors using a surface plasmon resonance biosensor (SPR)
3 0417 Aurore Van de WallePlatelet adhesion to engineered vascular grafts
CELL SOURCING, PRESERVATION AND MANIPULATION
4 0112 JIN SAN CHOIOptimized Cultivation of Human CornealEndothelial Cells for Transplantation
5 0114 Ingrid GarzónIdentification of Highly Viable Human
Fibrochondrocytes for Use in Tissue Engineeringof the Temporo-Mandibular Joint
6 0375 Amelia HelmsFabrication of Size-Controlled Cell Aggregates for Functional Muscle Tissue Regeneration
7 0096 Alexander HuberCell-ECM Aggregates for the Targeted Delivery of Cells to Sites of Regeneration
8 0046 Theodore I MalininLong-term in Vitro Maintenance of Cultures of Hyaline Cartilage Engineered from Segregated Chondrocytes.
9 0165 Theodore I MalininImplantation of Non-human Primate ParticulateCartilage into Athymic Rats
10 0378 Gemma PalazzoloIsoquercitrin-Induced Changes in NeuronMorphology: Possible Applications in NeuralNetworks
11 0411 Xiaohui ZhangNanoliter Droplet Vitrification for OocyteCryopreservation
DECELLULARIZED TISSUE MATRICES
12 0339 Tamer AboushwarebOptimization of Decellularized Scaffolds forWhole Organ Engineering
13 0382 Siba HaykalEvaluation of the Structural Integrity andExtracellular Matrix Components of TrachealAllografts following Cyclical DecellularizationTechniques : Comparison of Three Protocols
14 0138 Nick J. MernaNon-invasive optical imaging of re-cellularizinga cardiac extracellular matrix
15 0505 Sayed-Hadi Mirmalek-SaniOptimized Decellularization of Porcine Kidneysfor Whole Organ Engineering
16 0175 Naoko NAKAMURAFabrication of Bone Marrow Niche usingDecellularized Bone Marrow
17 0519 Sophia PilipchukCrosslinking Influences Dermis-DerivedHydrogel Stiffness and Degradation
18 0398 Shay SokerInfluence of Flow Rate on Pressure and CellSeeding Efficiency in Decellularized LiverBioreactors
19 0232 John WilliamsProliferation and Chondrogenic Differentiation of Human Adipose Derived Stem Cells andHuman Mesenchymal Stem Cells in a Needle-Punched, Porous, Decellularized Human Allograft-Derived Meniscus
20 0117 Maelene L. WongSequential, Differential Solubilization for AntigenRemoval in Xenogeneic Scaffold Generation
21 0446 Janelle L. WongEffect of Chaotropes on Antigen Removal inXenogeneic Scaffold Generation
DEVELOPMENTAL BIOLOGY AND TISSUE MORPHOGENESIS
22 0068 Yoonyoung KimDynamic Change of Mitochondrial Distributionof Pluripotent Stem Cells-DerivedCardiomyocytes
23 0334 Catherine K KuoMechanical Loading Effects on EmbryonicTendon and Ligament Cells <i>In Vitro</i> Varieswith Developmental Stage and BiochemicalCues
24 0479 Alison P. McGuiganShear-induced Morphological Response ofHuman Umbilical Vein Endothelial Cells inMicrochannels
25 0498 Alison P McGuiganEngineering cell-cell interactions to control tissuemorphogenesis in endothelial cell sheets
26 0384 Kenneth J WalkerEffect of Thermosetting Chitosan-GelatinHydrogels on Chondrogenesis
NANOBIOTECHNOLOGY FOR REGENERATIVE MEDICINE
27 0263 Elshad AbdullayevDrug loaded Halloysite/Polycaprolactone scaffolds for wound healing
28 0520 Ashkan AryaeiStudy of effect of Zinc Oxide nanoparticles on mechanical properties of chitosan matricesusing AFM
29 0480 Rohan S. BalkawadeBioactive Nanomaterials for Enhanced WoundHealing
30 0443 Jong Kyu HongSingle Cell on Single Nanofiber in ThreeDimensional Scaffold
31 0486CLEMENTE IBARRA PONCE DE LEONCartilage tissue engineering for auricular reconstruction. The use of chitosan-polyvinylalcohol hydrogels.
32 0023 Binata JoddarCovalently Immobilized Hyaluronic AcidSubstrates for Maintaining Pluripotency andProliferation of Embryonic Stem Cells for In Vitro Tissue Engineering.
33 0139 David K. MillsBioactive Hydrogels for TMJ Repair
34 0450 David K. MillsEffects of Mechanical Shear on Anisotropic TissueEngineered Construct as Potential TMJ Repair
35 0259 Wenbo WeiClay Nanotube / Poly(methylmethacrylate) Bone Cement Composites with SustainedAntibiotic Release
36 0523 Stefan ZornDecorating tissue engineering scaffolds withmodular growth factors
12
REPORTERS AND IMAGING FOR CELL TRACKING
37 0488 Khaled A. AamerLabel-Free Imaging of Prostate Cancer Cells byBroadband Coherent Anti-Stokes RamanScattering Microscopy
SKIN AND WOUND HEALING
38 0062 Luke R. BurnettKeratin Based Biomaterial (KeraHeal™) forTreatment of Cutaneous Radiation Injury
39 0222 Bin JiangInvestigation of Polyhexamethylene BiguanideContaining Poly(N-isopropylacrylamide)Hydrogels For Treatment of Infected Wounds
40 0143 Rutuja P KulkarniFunctionalized Nanofilms for AcceleratedWound Healing
41 0435 Yen-Chih LinHuman Adipose-Derived Stem Cell SheetsEnhance Wound Healing
42 0529 Glauco Souza3D Cell Culturing by Magnetic Levitation: The Bio-Assembler.
43 0200 Richelle C. ThomasThe Incorporation Of Electrically ConductingPolymers Within Biopolymer Hydrogels
44 0168 Cynthia E. Wilkins-PortAssessment of Dermagraft<sup>®</sup>Function in Mechanisms of Wound Repair
POSTER SESSION I • Monday, December 12, 2011
STEM CELL SOURCES, CULTURE AND CHARACTERIZATION
45 0203 Carlos Alberto AgudeloDesign of antibody-immobilized zwitterionictelomere brush surface for stem cell separationsystem
46 0324 Priya R BaraniakEffects of Human Platelet Lysate onMesenchymal Stem Cell Proliferation,Metabolism, and Senescence In Vitro
47 0308 Allison C BeanComparison of Chondrogenic Differentiation of Bone Marrow and Adipose-Derived Stem Cells Seeded on Electrospun Fibers of DifferentDiameters
48 0251 Barbara D. BoyanChondrogenic Media and Microencapsulation is Effective in Tailoring Adipose Stem Cell Trophic Factor Expression Regardless ofAnatomical Site, Passage, or Donor Age.
49 0437 Ana BrenaCulture of corneal limbal epithelial cells seededon a radioesterilized human amniotic membrane.
50 0255 Utkan DemirciLabel-free and Viable Stem Cell Isolation fromPeripheral Blood with a Disposable Microfluidic Chip
51 0116 Beena G. MohanThe effect of radio opaque strontium calciumphosphate implants loaded with autologous adipose derived mesenchymal Stem cells on the healing of lapine segmental bone defects
52 0057 Ingrid J GarzónGeneration of artificial human ectodermal tissuesusing an alternative cell source
53 0201 Ingrid GarzónComprehensive Gene Expression Analysis ofFibrous and Hyaline Chondrocyte Cultures forUse in Cartilage Tissue Engineering
54 0406 Sunil GeorgeThe Feasibility of using Autologous Renal Cellsfrom Diseased Kidneys for the Treatment ofRenal Failure55 0481 Adam HatchMicrofluidic Isolation of Endothelial ProgenitorCells for Tissue Engineering and Cell-BasedTherapeutics
56 0099 Niina M. HopperPeripheral Blood Derived Progenitor Cells inTissue Engineering57 0028 DIMITRIOS KOUROUPISEvaluation of mesenchymal stem cells (MSCs)from whole umbilical cord for bone repair applications
58 0442 Vijay KumarCharacterization of Bone marrow aspiratederived stromal cell (MSCs) concentrate for Mesenchymal cells (MSCs) using Res-Q<sup>TM</sup>60 BMC- a point of care system
59 0333 Catherine K. KuoReducing cytoskeletal tension can modulate the effects of hypoxia on adipogenesis of mesenchymal stem cells
60 0135 Lisa M LarkinUtilization of Adipose-Derived Stem Cells to Fabricate Scaffold-less Tissue EngineeredNeural Conduits
61 0179 Wen-Chi C. LeeCytokine Secretion Profile of Leporine-derivedMesenchymal Stem Cells
62 0132 Yong Li MatrixMetalloproteinase Inhibition Negatively AffectsMuscle Stem Cell Behavior
63 0153 Yong LiA Cre-Lox system based study of muscle cellplasticity after skeletal muscle injury in adultmouse
64 0492 Brenda K. MannHA-Based Hydrogels Seeded with Equine CordBlood-Derived MSCs for Tissue Repair in Horses
65 0147 Ville V. MeretojaEnhanced Chondrogenesis in Mesenchymal Stem Cell Cultures Supplemented with Articular Chondrocytes
66 0426 George F MuschlerConcentration and Selection of OsteogenicProgenitors using Magnetic Labeling based onHyaluronan Expression for ImmediateTransplantation into a Canine FemoralMultidefect Model
67 0455 Haruko ObokataThe generation of pluripotent spheres from adult stem cells
68 0364 Jennifer J PetscheAmniotic Fluid-derived Stem CellCharacterization and Differentiation through Co-cultures with Neonatal Rat Cardiomyocytes
69 0542 Christopher ProctorMesenchymal Stem Cells and Bone MarrowConcentrate Proliferate and Synthesize Matrix on a Synthetic Scaffold
70 0294 Felicity Rose‘Smart Culture’ of Mouse Embryonic Stem Cells
71 0487 AL Sesman-BernalThe Periosteum osteogenic potential using scaffold demineralized bone with an acellulardermis
13
STEM CELL SOURCES, CULTURE AND CHARACTERIZATION (Continued from Previous Page)
72 0335 Eric SpinettiSkeletal Stem Cells Distribution in the HumanMarrow Cavity: High Frequency in theSubendosteal Region
73 0015 John A SzivekFocal Cartilage Defect Repair: A Co-CultureStudy with Adipose Derived Stem Cells andChondrocytes
74 0286 Ryo TakagiMesenchymal cell-like phenotype of normalhuman epidermal keratinocytes cultured in lowcalcium concentration medium
75 0371 Alan TsengAuricular Cartilage Reconstruction by BoneMarrow-Derived Mesenchymal Stem CellsGrown in Chondrocyte Conditioned Media
76 0508 Ashley M. WittVariablity of Male and Female Donors ofMesenchymal Stem Cells Derived from HumanUmbilical Cords
77 0522 Nicole L. WriceIsolation and Characterization of BaboonAdipose-Derived Stem Cells
78 0151 Wen Xu Stem CellsIsolated from Skeletal Muscle Differentiate intoNeural Phenotypes
79 0035 Yuanyuan ZhangEndothelial differentiation of human urinederived stem cells
80 0036 Yuanyuan ZhangNeural differentiation of human urine derivedstem cells: potential use in functional bladder tissue regeneration
81 0037 Yuanyuan Zhang<i>In vivo</i> skeletal myogenic differentiationof human urine-derived stem cells: potentialapplication in the treatment of urinary incontinence
82 0038 Yuanyuan ZhangCharacterization of human urine-derived stemcells from the upper urinary tract for use in bladder regeneration in patients with end-stagebladder disease
83 0041 Yuanyuan ZhangFunctional urothelial differentiation of urinederived stem cells for potential use in urologicaltissue engineering
POSTER SESSION I • Monday, December 12, 2011
SYNTHESIS, FUNCTIONALIZATION ANDFABRICATION OF BIOMATERIALS
84 0260 Elshad AbdullayevEncapsulation and Controlled Release ofBioactive Agents by Biocompatible HalloysiteClay Nanotubes for Applications in Cosmetics
85 0346 Saniya AliInfluence of Cell-Adhesive Laminin Peptides onEndothelial Tubulogenesis
86 0309 Mária BahawdoryMechanistic Investigation of Cellular Adhesion to Keratin Biomaterials
87 0402 Eric M. BreyAngiogenesis in Engineered Tissues:Optimization via Computational andExperimental Analysis
88 0235 Pamela R Brown BaerInfluence of Porosity and rhBMP-2 on HealingUsing an Injectable Bone Regenerative Scaffold
89 0491 Mariana Carvalho BurrowsA Comparative Study of PET/collagen andPET/gelatin Hybrid Electrospun Scaffold as aModel for Vasculas Grafts
90 0351 Qingsu ChengIn-vitro evaluation of poly(lactide-<i>co</i>-gly-colide)/carbon nanotube scaffolds for bone tissueengineering
91 0432 Xingguo ChengElectrochemical aligned collagen sheet culturedwith mesenchymal stem cells (MSCs) for potential skin tissue regeneration applications
92 0240 Harish ChinnasamiRelating the Porosity of Poly (L-lactic acid)Scaffolds to Unidirectional Freezing (Thermal) Profiles
93 0128 Helen C CoxA Novel Injectable Scaffold For Bone RepairApplications
94 0083 Tanya M. FarooqueMeasuring 3Dness of Cell Morphology in TissueScaffolds
95 0434 Padraic J. FoleyAuto Cross-linking Polyelectrolyte Pairs toConformally Coat Individual Yeast Cells
96 0468 Jeffrey N HarrisCollagen and Polycaprolactone CompositeScaffold for Tissue Engineering
97 0269 Benjamin HarrisonElectrically Conductive Scaffolds Aiding SkeletalMyotube Formation
98 0270 Benjamin HarrisonBiodegradable Polymer Spheres LoadingAntibiotics and Iron Oxide Nanoparticles forControllable Drug Delivery
99 0415 Mohamad Nageeb HassanPreparation and Thermo-mechanicalCharacterization of 3D/Injectable PVA-BGComposite Hydrogel for Periodontal BoneRegeneration
100 0090 Xiaoming HeSmall (~ 100 µm) ACA(Alginate-Chitosan-Alginate) Microcapsules for Cell Microencapsulation
101 0511 Ting (Coco) HeNovel 3D Knitted Scaffolds for TissueEngineering Applications
102 0395 Ganesh C. IngavleBioactive Agarose-PEGDA InterpenetratingNetwork Hydrogels: Incorporation of CovalentlyLinked RGD Peptide and Entrapped AggrecanMolecules Improves Chondrocyte Viability andBiosynthesis
103 0171 Vaidehi JoshiMacro-Porosity Enhances Vascularization ofElectrospun Scaffolds
104 0271 Youngmee JungDevelopment of Non-Toxic and BioactiveScaffolds by Supercritical CO<sub>2</sub> forTissue Engineering
105 0275 Cassandra M JuranMechanical Characterization of a Freeze-DriedXenogenic Acellular Fibrocartilage Scaffold forTemporomandibular Joint Disc Regeneration
106 0050 Kyung Shin KangThe effects of mussel adhesive protein on boneformation on solid free-form fabrication-basedPCL/PLGA scaffold
107 0458 Khadija KathiriaPreparation of Electrospun Fibers from Poly(glycerol dodecanoate co-fumarate) and their Cell Adhesion Studies
108 0363 Jongman LeeEffect of Controlled Delivery of PDGF-BB UsingHeparin-Conjugated Electrospun PCL/GelatinFibers on Bioactivity and Cellular Infiltration
109 0397 Nancy M LeeResponse of Human Periodontal Ligament-Derived Cells on Aligned PolymerNanofiber Scaffolds
110 0276 Tak Lung LiAntibacterial Properties of Novel 1D ZnONanowires on Medical Grade 316L StainlessSteel Surface
111 0267 Hang Lin AlginateMethacrylation in Dimethyl Sulfoxide forPhotopatterning Tissue Engineering Scaffolds
112 0331 Jenny B. LinPoly(N-isopropylacrylamide) Grafted ontoMicrotextured Poly(dimethylsiloxane) for Aligned Cell Sheet Engineering
14
SYNTHESIS, FUNCTIONALIZATION ANDFABRICATION OF BIOMATERIALS(Continued from Previous Page)
113 0265 Chase S LinsleyFabrication and characterization of multi-component biomimetic scaffold for bonetissue engineering
114 0150 Xiaohua LiuSurface Engineering of Nanofibrous GelatinScaffolds with Non-Collagenous Proteins forBone Regeneration
115 0256 Viviane LuangphakdyCompetitive Assessment of Polymer-based Bone Scaffolds in the Canine Femoral Multi-Defect model
116 0126 Claudia MONTERO-MENEIDevelopment of pharmacologically activemicrocarriers transporting stem cells and releasing growth factors integrated in a thermosensitive injectable hydrogel for an efficient tissue engineering
117 0445 Mayra Montes CamachoHuman Embryonic-Like Proteins as a NovelDevice Coating
118 0409 Marc C MooreUse of a Lyophilized Human Umbilical Vein as a Cell-Seeded Vascular Graft Cultured in aPerfusion Bioreactor
119 0081 Naveen NagiahElectrospinning of poly(3-hydroxybutyricacid)/gelatin fibrous membrane: Fabrication,characterization and application in skin regeneration
120 0060 Guoguang NiuComparison between electrospun poly(epsilon-caprolactone)/collagen scaffoldscross-linked with genipin and glutaraldehyde for vascular graft applications
121 0061 Guoguang Niu<sub>Fabrication of gelatin hydrogel sheet forthe transplantation of cornealendothelium</sub>
122 0233 Jagdeep T. PodichettyDIFFUSIVITY AND PRESSURE DROP STUDIESIN FLOW-THROUGH AND PARALLEL-FLOWBIOREACTORS DURING TISSUE REGENERATION
123 0341 Rameshwar RaoMineralization of Cell-Seeded Collagen-ChitosanMatrices using Modified Culture Medium
124 0477 Julio C Rios CamachoA Simplified Method to Isolate FunctionalHuman Hemoglobin for Tissue EngineeringPurposes
POSTER SESSION I • Monday, December 12, 2011
125 0418 Maria A. Romero<i>In Vitro</i> Hydrolytic Degradation Studyof Porous and Non Porous Nerve GuidesFabricated with Biodegradable Polyesters
126 0074 S.I Roohani-Esfahani<i>In-vivo</i> bone regeneration in critical sizebone defect by using of nanocomposite scaffolds
127 0264Seyed-Iman Roohani-EsfahaniEffect of Nanofibrous Silk/PCL Modification on In-vitro Behaviour of Calcium PhosphateScaffolds
128 0245 Ariella ShikanovNatural and synthetic hydrogels for ovarian follicle culture in vitro.
129 0254 Tatsiana ShutavaLayer – by – Layer Nanoencapsulation ofAnticancer Drug Camptothecin
130 0368 Anirudha SinghThe stem cell behaviour on a multifunctionalsynthetic PEG hydrogel with independent controlof mechanical and bioadhesive properties.
131 0387 Marissa R. SolomonThe Design and Study of a PEG-ECM Hydrogelfor Controlled Cell-Mediated Cartilage Repair
132 0048 John A. SzivekA Novel Medial Condyle Surface ReplacementScaffold Facilitates Cartilage Regeneration
133 0278 Keisuke TakanariCreating a biohybrid material for fascial repair by regionally-controlled processing of an extracellular matrix digest with a biodegradable elastomer
134 0449 Nisarg M. TambeSurface Bioactivation and CollagenImmobilization on Polylactic Acid Fiber Scaffolds
135 0517 Richelle C ThomasPeptide Conjugation in Hyaluronic AcidHydrogels
136 0144 Tiffany N. VoInjectable PNiPAAm-Based Scaffolds withTunable LCST for Craniofacial BoneRegeneration
137 0210 Tzu-Wei WangDevelopment of Thermosensitive andBiocompatible Pluronic F127/Hyaluronic AcidHydrogel as Anticancer Drug Carrier
138 0236 Lisa J WhiteControlling the Morphology and MechanicalBehaviour of Supercritical Carbon DioxideFoamed Scaffolds
139 0239 Lisa J WhiteSpatio-temporal control of growth factor deliveryfrom PLGA microparticles
140 0207 Hsi-Chin WuIn Vitro Characterization of MagneticHydroxyapatite Nanocrystallines for TissueEngineering Applications
141 0056 Kelvin W. K. YeungEnhanced Cytocompatibility of BiomedicalMagnesium-Aluminum-Zinc Alloy by a Special Thermal Treatment
142 0211 Kelvin YeungA Novel Biodegradable Polycaprolactone-Magnesium Composite for Orthopaedic Applications
143 0010 Samer ZakyA Load-transducing Scaffold for BoneRegeneration
144 0514 Stefan ZornSpecific and reversible growth factor sequestering and release from PEG based Hydrogels
15
POSTER SESSION II • Tuesday, December 13, 2011
ARTIFICIAL STEM CELL NICHES
1 0299 Karla S HudsonDifferentiation of Human Adipose DerivedMesenchymal Stem Cells on DemineralizedCancellous Bone Grafts Under OsteogenicConditions.
2 0181 Kaiming YeEnhanced Human Embryonic Stem CellProliferation and Differentiation byPhysicochemical Cues
BIOREACTOR TECHNOLOGIES
3 0459 Keith BaarDefined electrical stimulation parametersemphasizing excitability for the developmentand testing of engineered skeletal muscle
4 0283 Yuki KagawaA Feasibility Study on Monitoring the State ofCulturing Myocardial Tissues by the GlucoseMetabolism Measurement
5 0049 Kyung Shin KangThe effects of a low-frequency electromagneticfield on osteogenic differentiation of human adipose-derived stem cells
6 0471 Vincent H PaiCharacterizing Strain of a Bioreactor for RabbitCorneal Fibroblasts – Experimental Verification of Finite Element Models
7 0221 Subha Narayan RathOsteoblasts and Bone-Marrow Stromal Cells inThree-Dimensional Biphasic Calcium PhosphateScaffolds: The Effect of Bioreactor on CellSurvival and Differentiation
8 0332 Joseph S. UzarskiPhysiologically Modeled Shear Stress as aFunction of Pulse Frequency: Driving EndothelialCells Toward a Quiescent Phenotype
9 0231 Andrew B. YeattsTowards Vascularized Bone: Dynamic Culture of hMSCs and Endothelial Cells in a TubularPerfusion System
CANCER
10 0104 Jacob E ShokesCharacterization of Chemotherapy / RadiationTreated Human Smooth Muscle Cells for Use in Regenerative Medicine
CARDIAC AND CARDIOVASCULAR
11 0377 Juna Arenas-HerreraElectrospun Vascular Scaffold for EngineeringCellularized Small Diameter Blood Vessel
12 0416 Hesham AzizgolshaniTissue Engineering a Bio-inspired Pump fromBiological Building Blocks
13 0085 Jean-MIchel BourgetAlignment of Vascular Cells via MicropatternedSurfaces Improved Vessel Properties
14 0475 George J. ChristSMOOTH MUSCLE CELLS CONFER EARLYFUNCTIONAL REMODELING OF TISSUE ENGI-NEERED ARTERIO-VENOUS FISTULA GRAFTSIN AN OVINE MODEL
15 0355 Emily A GonnermanAnisotropic Collagen-GlycosaminoglycanScaffolds Differentially Promote Beating in HL-1Cardiomyocytes
16 0072 Binata JoddarArterial pO2 Modulates PathologicalRemodelling in Human Saphenous Veins via an eNOS- and Superoxide-dependent Pathway
17 0347 Lucrezia A MorticelliInvestigation of the Suitability of DecellularisedPorcine Pericardium for Mitral Valve Repair
18 0164 Jochen RingeHuman Endomyocardial Biopsy DerivedAdherent Proliferating Cells Improve CardiacFunction <i>In Vivo</i>
19 0521 Marsha W RolleA cellular self-assembly approach to generatemodel human vascular tissue
20 0472 Michael S. SacksUse of finite deformation during in-vitro conditioning dramatically enhances de novoextracellular matrix production and mechanical properties.
21 0428 Zehra TosunImproved recellularization of engineered scaffolds using directed transport gradients
22 0142 Bo Wang MyocardialScaffold-based Cardiac Tissue Engineering:Application of Coordinated Mechanical andElectrical Stimulations
23 0193 Feng ZhaoIn-Vivo Remodeling of Scaffold-free Small-diameter Blood Vessels with AlignedHuman Mesenchymal Stem Cells
CLINICAL TRIALS
24 0305 Clemente IbarraTwo Year Follow Up of Arthroscopic Implantationof Matrix-Seeded Autologous Chondrocytes atthe Knee
25 0186 Jonathan MansbridgeStimulation of Hair Growth by Hypoxic Cell-Secreted Proteins
DISEASE MODELS AND DRUG TESTINGPLATFORMS
26 0380 Lauren D. Black IIIThe Development of a Fibrin Gel BasedEngineered Myocardium Model of MyocardialInfarction
27 0441 Jon CheethamThe horse as a preclinical model for regenerative medicine approaches for laryngealreconstruction
28 0536 Paul C. SchillerRegenerative Capacity of MIAMI Cells isMediated by the Repair and FunctionalModulation of Multiple Tissue Compartments
ECM AND MECHANOTRANSDUCTION
29 0319 Matthew T. HarrisA Method for Aligning Cells and ApplyingHomogenous Tensile Strain in Collagen Gels
30 0095 Rami MhannaThe Effect of Chondrocyte Morphology on theirResponse to Mechanical Compression
31 0451 John H. SlaterSimultaneous Investigation of the Influences ofBiophysical & Biochemical Cues on DirectionalCell Migration
32 0414 Justin S. WeinbaumMonitoring Collagen Expression in MechanicallyStimulated Bioartificial Arteries
33 0526 John M WilliamsNovel Tensile Strain Bioreactor for Analysis ofPrimary Cilia-Extracellular Matrix Interactions inAdipose-Derived Stem Cells
ENDOGENOUS STEM CELL HOMING34 0390 Anusuya DasSphingosine-1-Phosphate (S1P) Receptor SpecificSmall Molecules Modulate Endogenous StemCell Homing for Bone Regeneration
IMMUNOLOGY AND TISSUE RESPONSES35 0527 Siwoo ChoHigh Function and Viability of a IsletTransplantation Capsule with a AnodicAluminum Oxide Nanochannel Membranes withSelective Blocking Immunoglobulin G
36 0399 Bailey V. FearingA Keratin Biomaterial Promotes a BeneficialInflammatory Response Following Spinal CordHemisection Injury
16
IMPACT OF ECM COMPOSITION ON CELLFATE AND TISSUE FORMATION
37 0470 Ben AntebiSecretion of Extracellular Matrix RepressesProliferation of Mesenchymal Stem Cells in 3DCultures
38 0213 Stephen F BadylakThe Consequences of IneffectiveDecellularization on the Host Response toBiologic Scaffolds
39 0425 Sarah CalveHyaluronic Acid Content in Skeletal Muscle isIncreased via Upregulation of HAS2 and HAS3During Muscle Hypertrophy
40 0379 Kelly C. ClauseStiffness as an Effector of Lung BranchingMorphogenesis
41 0311 Joaquin CortiellaProduction and Evaluation of Acellular PigTrachea-Lung Scaffold
42 0310 Anita Driessen-Mol VitaminStimulation to Enhance Collagenous and ElasticNetwork Formation by Human Adult VascularCells in Valvular and Vascular Tissue Engineering
43 0499 Monica FahrenholtzCell-derived ECM on CaP scaffold enhanceshBMSC behaviour and delivery of BMP-2
44 0230 Kimberly M. FerlinCentrifugation Adhesion Assay for Characterizingthe Phenotype of Chondrocytes
45 0361 Sunyoung Joo<i>In vitro</i> generation of three-dimensionalfunctional ovarian structures
46 0321 Kathryn A KuklaEvaluation of Adipose ECM Gels for BreastReconstructive Surgery
47 0325 Catherine K KuoElaboration of mechanical and biochemicalproperties of embryonic tendon during development
48 0439 Wan-Ju LiSynergistic Effect of Surface Topography andChemistry of Extracellular Matrix on Regulationof Osteogenesis
49 0242 Jeremy J LimDesulfated Chondroitin Biomaterials UpregulateGene Expression of Cartilaginous ECM byHuman Mesenchymal Stem Cells in the Presence of TGF-‚1
50 0174 Ivan Marcos-Campos Bone ScaffoldArchitecture Affects Developmentof Bone Grafts from Human Embryonic StemCells
POSTER SESSION II • Tuesday, December 13, 2011
51 0360 Eric HD NguyenEnhanced-Throughput Screening of EndothelialCell Interactions with Synthetic, BioactiveHydrogels
52 0124 Neerav D. PadliyaA Mass Spectrometry-Based Proteomic Methodto Profile Proteins Secreted by Cells Interactingwith the Extracellular Matrix
53 0317 Yongzhi QiuDegradability of MMP-Sensitive HydrogelsModulates Cell Shape and Early OsteogenicDifferentiation of iPS-Derived Mesenchymal-likeCells
54 0422 Ana Y. RiojaFibrillar Collagen for Tendon Tissue Engineering
55 0403 Thomas D ShupeGrowth factor retention on decellularized ratliver matrices derived from normal and regenerating liver.
56 0452 Aleksander SkardalThe Impact of Substrate Elasticity on AmnioticFluid-Derived Stem Cell Phenotype
57 0178 Patricia S SoucyEndothelial cell response to poly ethylene glycol hydrogels containing basic fibroblastgrowth factor
58 0058 Bill J. TawilAssessment of Keratinocyte and FibroblastMigration on Fibrin and Collagen Matrices ofDifferent Compositions on a Novel 3D SkinEquivalent Wound Model
59 0091 Yuanyuan ZhangTissue Specific 3D Gel Culture Model ForFunctional Cell Culture
MANUFACTURING, SCALE-UP ANDAUTOMATION
60 0127 Mohit B. BhatiaDevelopment of a High Yield Process for theIsolation of an Extracellular Matrix from theHuman Placenta Amenable to CommercialProduction
MICROFABRICATION, PRINTING, ANDPATTERNING TECHNOLOGIES
61 0134 Peter D. GabrieleFiber Nanopattern Features Using HighDefinition Microextrusion (HDME)
62 0290 Aaron GoldsteinFabrication of a 3D PLGA/PEGDA Scaffold forLigament Tissue Engineering
63 0052 Akiko HisadaA Novel Spheroid Culture Device withNanopillar for Cryopreserved HumanHepatocytes
64 0496 Brett C IsenbergStructural and mechanical properties of patterned cell sheets for arterial tissue engineering
65 0032 Liyang Jiang3-D Assembly of HUVECs on Patterned HydrogelMatrices: A Model for Microvessel Engineering
66 0367 Hyun-Wook KangDevelopment and Validation of an IntegratedOrgan Printing System
67 0464 Vivek A KumarGenereation of mechanically robust collagen-based biomaterials with defined laser ablated patterns for soft tissue engineeing.
68 0337 Vivian A LeBioprinting by Continuous Material Deposition
69 0284 JunHee LeeFabrication and Characterization of PLLA/PDOBlended Scaffold using 3D Plotting System
70 0501 Neethu MohanMicrosphere-based continuous gradient scaffoldfor effective regeneration of the osteochondralinterface
71 0359 Sang-Hyug ParkBiofabrication of Muscle Scaffolds using anIntegrated Organ Printing System for theEngineering of Functional Muscle Tissue
72 0300 Felicity RoseNovel Method to Develop Electrospun FibreBased Scaffolds with Tailored Geometries
73 0192 Jeff SakamotoPatterning highly ordered and hierarchical hydrogels for nerve repair
74 0413 Michael J. SawkinsBioprinting as a Novel Tool for OsteochondralTissue Engineering
75 0190 Binil StarlySpatially Printed Electrically ConductivePoly-Pyrrole (PPy) Ultra-Fine Fibers Embeddedwithin 3D Poly-Caprolactone (PCL) Porous 3D Scaffolds
76 0289 Wojciech SwieszkowskiFetal or Adult Mesenchymal Stem Cells and 3DComposite Scaffolds for Bone Tissue Engineering
77 0157 Halil TekinMimicking biological complexity via dynamicmicromolding
78 0209 Kisuk YangMicrofluidic Platform for Quantitative Analysis of Neural Stem Cell Differentiation in 3DExtracellular Matrix Microenvironment
17
MUSCULOSKELETAL, CRANIOFACIAL AND DENTAL
79 0419 James BlanchetteOsteogenic differentiation of adipose derivedstem cells in varied oxygen concentrations
80 0008 Jose A CansecoEnhanced Ligament Marker Expression By Direct Co-Culture Of Pig Mesenchymal StemCells (MSCs) And Primary Anterior CruciateLigament (ACL) Cells
81 0261 Kelly Chen-LeungEarly Assessment of Volumetric Muscle LossRepaired With Muscle Derived ExtracellularMatrix
82 0195 Benjamin T. CoronaTissue Engineered Skeletal Muscle RepairConstructs Mediate Functional Recovery in a Rat Model of Volumetric Muscle Loss Injury
83 0122 Tracy L. CriswellCell therapy for the treatment of compartmentsyndrome in rats.
84 0014 James DennisTantalum-cartilage-Mesenchymal Stem CellComposites for Joint Repair
85 0338 Warren L GraysonInducing Mesenchymal ‘Condensation’ Enhances Subsequent Chondrogenesis of MSCs
86 0301 Allan M HensleeDevelopment of a Biodegradable Bone Cementfor Craniofacial Applications
87 0353 Chang Mo HwangA Tissue Engineered Cartilage CoveredAlloplastic Implant for Auricular Reconstruction
88 0223 Esmaiel JabbariEffect of BMP2 peptide grafted nanoparticles on osteogenic expression of stromal cells encapsulated in a hydrogel
89 0224 Kyobum KimDual Growth Factor Release from BilayeredOligo(poly(ethylene glycol) fumarate) Hydrogels
90 0349 Jaehyun Kim<i>In Vitro</i> Osteogenic Differentiation ofHuman Amniotic Fluid-derived Stem Cellswithin Hybrid Scaffolds for Bone Tissue
Engineering
91 0474 Ann LeeMuscle-tendon-bone constructs engineered withfunctional musculoskeletal interfaces
92 0025 ZF LuBone structure-mimicking scaffold andOsteoblasts Synergistically Induce OsteogenicDifferentiation of Adipose Tissue-derivedMesenchymal Stem Cells
POSTER SESSION II • Tuesday, December 13, 2011
93 0509 Venkata MantripragadaCharacterization of chitosan microparticles forsustained release of growth factor and studyits effect on osteoblast cell attachment and proliferation
94 0381 Sang-Hyug ParkCell laden gelatin fiber contained calcium phosphate biomaterials as a stem cell deliveryvehicle for bone repair
95 0106 Elizabeth L Pettit KnellerHuman Skeletal Muscle Myoblast Growth andDifferentiation on Keratin Biomaterials
96 0408 Christopher R. RathboneSurvival of Freshly Isolated Stem Cells DeliveredAfter Ischemia-Reperfusion Injury
97 0478 Shaun A. TannerControlling the Release Profile of FTY720 inOrder to Guide Tissue Regeneration in CranialBone Defects
98 0506 W.Y. TongRoughened substrate suppress proliferation ofmesenchymal stem cells and is associated withcell-cell contact.
99 0013 Dong-An WangA Novel Scaffold-Free Living Graft for TissueRegeneration
100 0039 Anna E. WilhelmPhotocrosslinked PEG Microwells for Synthesisof Cartilage Micropellets and Study ofInflammatory Responses
101 0019 Masaya YamamotoEnhanced osteogenesis and angiogenesis of bone marrow-derived cells by controlled release of growth factors and chemokines toinduce bone regeneration.
102 0293 Li ZengTissue engineering under inflammatory conditions: the effect of scaffold material on cartilage stability
NEURAL
103 0545 Jared BushmanRe-Tasking an FDA-Approved Drug for Use inPeripheral Nerve Regeneration
104 0045 Lauren E. CornellAligned Carbon Nanotube-Collagen Fibers andTheir Use in Guiding Neuron Progenitor CellGrowth
105 0076 Dong Nyoung HeoCell fouling resistant PEG coating on polyimidefilms for neural implant applications
106 0160Seyed Abdolreza Mortazavi TabatabaeiAUTOLOGOUS GRAFT TRANSPLANTATIONOF NEURAL CELLS VIA ENDOMETRIAL STEMCELL NEUROGENESIS
PEDIATRIC, FETAL, OR NEONATALAPPLICATIONS
107 0089 Thomas W. Gilbert<em>In Vivo</em> Assessment of MagnesiumAlloys for Potential Use as a Degradable Stent for Treatment of Pediatric Airway Obstruction
108 0167 Ariella ShikanovFibrin-mediated delivery of an ovarian folliclepool in a mouse model of infertility
109 0094 Miho WatanabePreliminary Optimization of Cellular Seeding ofGelatin Scaffolds for Fetal Treatment ofMyelomeningocele
PRE-CLINICAL STUDIES
110 0173 Benjamin T KibaloMatriStem MicroMatrix®-based HaemostaticDressings are Effective in Acute Haemorrhage.
111 0252 Haofan PengA novel arterio-venous shunt model for testingtissue engineered vascular grafts from hair follicle stem cells
REGULATORY AND COMMERCIALIZATIONISSUES
112 0279 Michael DornishTissue Engineered Medical ProductStandardization - the ASTM InternationalCommittee F04
18
SOFT TISSUE REPAIR
113 0454 Ellen M. ArrudaTissue Engineered Bone-Ligament-BoneConstructs Following 9-Month ACL replacementin Sheep
114 0214 Stephen F BadylakBiologic Scaffolds for Skeletal MuscleReconstruction
115 0348 Chang Mo Hwang<i>In vitro</i> and <i>In vivo </i>evaluations of a fibrin/alginate hybrid hydrogel for soft tissue repair
116 0196 Jacob KofflerThe relay race to integration of engineered vascularized graft
117 0148 Yong LiIschemia Reperfusion Induces Fibrosis Formation in the Skeletal Muscle of Mice
118 0152 Yong Li Regeneration of Soft Tissues is Promoted by MMP1Administration after Digit Amputation in Mice
119 0185 Mon-Tzu A LiQuantitative Characterization of a NovelVolumetric Muscle Loss Model in the Rat
120 0345 Nelson L. ScarboroughInfluence of processing methodology and source on porcine dermis biological responsesand biophysical characteristics.
121 0285 Kelvin WK YeungFlexible, Channeled Nerve Guidance Conduit
122 0065 Yuanyuan ZhangImplantation of autologous urine derived stemcells expressing vascular endothelial growth factor for potential use in the treatment of neurovascular erectile dysfunction
POSTER SESSION II • Tuesday, December 13, 2011
UROLOGIC
123 0502 Sigrid M. AgcaoiliPrimary Renal Cell Seeding in a FullyDecellularized Porcine Renal Scaffolds,Preliminary Results of Cell Organization
124 0009 Hazem OrabiTissue Engineering of Smooth Muscle fromAdipose Tissue Derived Stem Cells forGenitourinary Reconstruction
125 0059 Gustavo VilloldoDIFFERENCES IN URETHRAL REGENERATIVEPATTERNS POST URETHROPLASY USINGSMALL INTESTINE SUBMUCOSA IN A RABBITMODEL WITH INJURED URETRHA
VASCULARIZATION OF ENGINEERED TISSUES
126 0354 James O. Blanchette CuingRelease of Angiogenic Factors from Adipose-Derived Stem Cells (ADSCs) Using Hypoxia:Towards Vascularization of Tissue-EngineeredBioscaffolds
127 0066 Nolanne ChangOptimizing Components of an AngiogenicScaffold System for Bone Regeneration
128 0079 Tracy L. CriswellThe use of fluorescent imaging to detect the neovascularization and differentiation of skeletalmuscle in vivo.
129 0386 Omaditya KhannaMultilayered alginate microbeads for the localstimulation of neovascularization
130 0026 Yu Bin LeeDevelopment of Dual-Factor ImmobilizedSubstrates Using Bio-Inspired Coating Method for The Stimulation of Angiogenesis
131 0199 Ayelet LesmanEngineering Vessel-Like Networks withinMulticellular Fibrin-Based Constructs
132 0266 Kristen M LippertEnhanced Vascular Migration in CD47-nullTrachea133 0018 Lei TianImpact of Pericytes on Vessel Formation andAnastomosis in Prevascularized Tissues
134 0055 Maxime TondreauA human tissue-engineered vascular substitutewith a nitric oxide-producing vasa vasorum
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December 2011
Dear Students, Young Investigators, and Conference Attendees,
Welcome to Houston and thank you for joining us at TERMIS-NA 2011!
The TERMIS Student and Young Investigator Section North America (SYIS-NA) Meeting Committee has prepared a special program for students and post-docs to foster career development and encourage networking and interaction with experts in the field. We hope you enjoy our program and find it stimulating!
The SYIS program opens on Monday afternoon with a Career Panel during the coffee break from 2:30-3:00 PM. Come hear about career paths from experts in academia, industry and the NIH. Monday evening, the SYIS is hosting a reception at the BioScience Research Collaborative building on Rice University’s campus. Come and enjoy drinks and hors d’oeuvres and tours of laboratories in the building.
On Tuesday, join us for the Student Meet Mentor Lunch (sign-ups at registration). Don’t miss this opportunity to havelunch and talk with leaders in the field of regenerative medicine. Want to take a more active role in the student activities of TERMIS- NA SYIS? Join us for the annual SYIS- NA Business Meeting during the coffee break on Tuesdayfrom 2:30-3:00 to learn how you can be a part of SYIS and the future of regenerative medicine.
SYIS is excited to sponsor the SYIS- NA Poster Competition. The top 25 student and young investigator posters (authors were notified prior to the conference) will be judged by senior faculty members, with awards for 1st place($300), 2nd place ($200), and 3rd place ($100). Poster award winners will be announced on Wednesday after thePlenary Lecture at 8:00 AM.
We hope you have a fantastic TERMIS- NA Meeting and look forward to meeting you!
Kind Regards,
Patrick Spicer Sayed-Hadi Mirmalek-Sani SYIS- NA Meeting Chair SYIS- NA Chair
Christine Kowalczewski Chris BashurSYIS- NA Vice Chair SYIS- NA Secretary
Rebecca Dahlin Robert GauvinSYIS- NA Treasurer Scientific & Professional Development Committee Chair
STUDENT WELCOME LETTER
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TERMIS- NA STUDENT & YOUNG INVESTIGATOR SECTION (SYIS)
SYIS POSTER COMPETITIONJudging: Monday, Dec 12th & Tuesday, Dec 13th,
4:30-6:00 PM at Poster Sessions
Awards: Wednesday, Dec 14th, after the 8:00 AM Plenary Talk
The top 25 young investigator posters, as scored by theabstract reviewers (authors were notified prior to the
conference), will be judged by selected faculty.SYIS Poster Competition posters will remain up for both
Poster Sessions I and II. Awards for 1st place ($300), 2nd place ($200), and 3rd place ($100) will be given.
SYIS RECEPTION AND LABORATORY TOURS AT THE BIOSCIENCE RESEARCH COLLABORATIVE
OF RICE UNIVERSITYMonday, December 12th
6:30-9:00 PM • Rice UniversityMeet in the hotel lobby at 6:00 PM
for shuttle service to Rice University.Reception for SYIS member at Rice University with
hors d’oeuvres and drinks. Tours of laboratories investigating tissue engineering and regenerative medicine will be given
by students of Rice University.
2 0 1 1 P R O G R A M
CAREER PANELMonday, December 12th
2:30 – 3:00 PM • Grand Ballroom KLA panel made up of representatives from academia,
industry and the NIH. Come and hear about career pathsthrough each of these areas.
SYIS- NA BUSINESS MEETINGTuesday, December 13th
2:30-3:00 PM • Grand Ballroom KLThe annual TERMIS SYIS-NA business meeting is open
to all students and young investigators. Attend this meeting to learn more how to get involved in SYIS.
STUDENT MEET MENTOR LUNCHTuesday, December 13th
12:00-1:30 PM • Room 335ABThe Student Meet Mentor Lunch gives 51 SYIS members the opportunity to enjoy a plated lunch with 17 mentors,
with seating arranged by student preference. Mentors include Session Chairs, members of the Scientific
Advisory Committee, and local industry leaders. Sign-ups at the registration desk.
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STUDENT POSTER COMPETITION
ARTIFICIAL STEM CELL NICHESS 1Ben AntebiEffect of Oxygen Tension on theProliferative Activity of MononuclearCells and Human Mesenchymal StemCells
ASSESSING ENGINEERED TISSUES INVITRO AND IN VIVOS 2Joseph UzarskiDevelopment of a Novel Flow ChamberFor Real-time (Direct) Analysis of Blood-Biomaterial Interactions
CARDIAC AND CARDIOVASCULARS 3Aditya KumarIn Vitro Modeling of the Effect ofGentamicin on Aortic Valve InterstitialCell CalcificationS 4Tracy GwytherCell-Derived Vascular Tissue TubesGenerated by Fusion of Aggregated CellRings
CELL SOURCING, PRESERVATION AND MANIPULATIONS 5Warren GraysonXeno-Free Conditions for the EndothelialDifferentiation of Adipose-Derived Stem Cells
DISEASE MODELS AND DRUG TESTING PLATFORMSS 6RebeccaHaydenModulating Bone Formation andResorption with Tethered PTH for a TissueEngineered Model of Osteoporosis
GENE THERAPYS 7Keerthana DevarajanAdenoviral Mediated Gene Delivery toHuman Umbilical Cord MesenchymalStromal Cells for Inner Ear Hair CellDifferentiation
IMPACT OF ECM COMPOSITION ONCELL FATE AND TISSUE FORMATIONS 8Jeremy MercuriAssessment of Human Stem CellDifferentiation on a Biomimetic Scaffoldfor Nucleus Pulposus Tissue Engineering
S 9Marilyn MarkowskiModulation of epithelial to mesenchymaltransition through the control of theextracellular matrix microenvironment
S 10Partha DebTowards Correlating Spatio-TemporalVariations in ECM Microenvironmentswithin Abdominal Aortic Aneurysms(AAAs) to Cellular Responses to MatrixRegenerative Therapies
CRANIOFACIAL AND DENTALS 11Allison BeanEffects of Seeding Density and FiberDiameter on Chondrogenesis ofMesenchymal Stem Cells In Vitro
S 12Alan TsengAdvances in the Development ofEngineered Ear
S 13Olive MwizerwaReplacement Innervated andVascularized Skeletal Muscle forCraniomaxillofacial Reconstruction
S 14Peter YangTensile Culture Upregulates TendonFibroblast Genes in MSCs EncapsulatedWithin Enzyme-Sensitive PEG Hydrogels
NEURALS 15Gary CatigExperimental and Computational Modelsof Neurite Outgrowth in Response toControlled Diffusive Gradients inMicropatterned
SKIN AND WOUND HEALINGS 16Sukeerth ChallagundlaDesign of Smart Nanofilms with bFGFand PDGF-BB for Wound Repair
CULTURE AND CHARACTERIZATIONS 17 Brian DiekmanChondrogenesis of Induced PluripotentStem Cells: Purification of DifferentiatedCells for Tissue Engineering
S 18Nicole WriceDebrided skin: a source of autologousstem cells for wound repair and regeneration
S 19Ami AminiComparative Analysis of EndothelialProgenitor Cells Isolated from PeripheralBlood and Bone Marrow for EnhancedVascularization in Bone TissueEngineering Applications
FUNCTIONALIZATION ANDFABRICATION OF BIOMATERIALSS 20Aubrey FranciscoLaminin-Functionalized Biomaterials forIntervertebral Disc Regeneration
S 21Christopher DosierManipulating Hydrogel Formation toPromote Prolonged Cell Viability in vitro
S 22Christopher HermannNovel Click-Hydrogel Therapy forJuvenile Murine Model of Re-Synostosis
S 23Michael TurturroPEGDA Hydrogel Gradients Produced byPerfusion Based Frontal PolymerizationStimulate Directed Cell Invasion
VASCULARIZATION OF ENGINEERED TISSUESS 24Seema EhsanIntermittent hypoxia conditioning of invitro vascularized tissue
S 25Yu-Chieh ChiuControlled Neovascularization withinPorous Poly (ethylene glycol)
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TERMIS-NA Conference and Exposition 2011
The Wake Forest Institute for Regenerative Medicine is committed to the development and dissemination of novel therapies for the repair and replacement of diseased tissues and organs. One way to achieve this goal is to foster thecareers of young investigators to encourage them to find solutions to problems in regenerative medicine. As part of thiseffort, the Wake Forest Institute for Regenerative Medicine Young Investigator Award was first awarded at the TERMIS-NA Conference and Exposition in 2008. The award is designed to recognize outstanding achievements bymembers of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) who is in the early stagesof a career in regenerative medicine.
The award consists of a certificate, $2500 cash prize, and recognition at the 2011TERMIS-NA Conference and Expo. We are pleased to announce this year’s winners: Brian O. Diekman and Melissa Krebs, Ph.D.
Brian O. Diekman is a Ph.D. student in Biomedical Engineering at Duke University and a NationalScience Foundation Graduate Research Fellow. He is a member of the Orthopaedic ResearchLaboratories and is advised by Dr. Farshid Guilak. He has authored seven publications, including a 2010 paper in Tissue Engineering that investigated a cartilage-derived matrix scaffold with adipose-derived and bone marrow-derived stem cells for cartilage tissue engineering. Brian’sresearch on characterizing murine mesenchymal stem cells from MRL/MpJ “superhealer” miceearned distinction as one of the 50 best abstracts at TERMIS-EU in 2010. His current work involvescellular therapy approaches for the prevention of post-traumatic arthritis, as well as using
differentiated induced pluripotent stem cells to model cartilage healing. After earning a B.S in Biomedical Engineeringfrom Duke in 2005, Brian received a Fulbright Student Grant to perform stem cell research at the RegenerativeMedicine Institute in Galway, Ireland. Brian is active in the Durham community through coaching youth basketball and tutoring high school math.
Melissa Krebs, Ph.D. is an American Cancer Society Postdoctoral Fellow and a ResearchAssistant Professor in Biomedical Engineering at Case Western Reserve University in Cleveland,OH. She is a member of Eben Alsberg’s lab at Case Western Reserve University, and is currentlyperforming research as a Visiting Scientist in Douglas Graham’s cancer biology lab at Universityof Colorado - Denver. Melissa received a B.S. and M.S. in Chemical Engineering from theUniversity of Rochester in 2002 and 2003, respectively. She then worked as a member of thetechnical staff in bioengineering at Charles Stark Draper Laboratory, Inc. in Cambridge, MA,from 2003-2006; her work at Draper was primarily focused on the development of a hand-heldion mobility spectrometer for applications in biodefense and medical diagnostics. She returnedto graduate school to pursue a Ph.D. in Biomedical Engineering in the field of biomaterials andtissue regeneration from 2006-2010, and was awarded a National Science Foundation GraduateFellowship. In her thesis research, Melissa developed biopolymer scaffolds for the controlled release of bioactive factorsto aid in tissue regeneration. Specifically, she was interested in promoting bone formation by guiding the differentiationof mesenchymal stem cells down the osteogenic lineage through gene delivery. Her current studies are focused on thecontrolled, localized delivery of short interfering RNA (siRNA) from biopolymer hydrogels, with applications both in tissue regeneration and cancer therapeutics.
Congratulations to Brian and Melissa!
WAKE FOREST INSTITUTE FOR REGENERATIVE MEDICINE YOUNG INVESTIGATOR AWARD
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LIFETIME ACHIEVEMENT AWA R D :Robert S. Langer is the David H. Ko ch Institute Professor(there are 14 Institute Professors at MIT; being an InstituteProfessor is the highest honor that can be awarded to afaculty member). Dr. Langer has written more than 1,140articles. He also has approximately 800 issued and pending patents wo r l dwide. Dr. Langer’s patents havebeen licensed or sublicensed to over 220 pharmaceutical,chemical, biotechnology and medical device companies.He is the most cited engineer in history.
He served as a member of the United States Food andDrug A d m i n i s t ra t i o n ’s SCIENCE Board, the FDA’s highesta dvisory board, from 1995 — 2002 and as its Chairmanfrom 1999-2002.
D r. Langer has received over 200 major awa r d sincluding the 2006 United States National Medal ofScience; the Charles Stark Draper Prize, considered thee q u ivalent of the Nobel Prize for engineers, the 2008Millennium Prize, the wo r l d ’s largest technology prize and the 2012 Priestley Medal, the highest award of theAmerican Chemical Society. He is the also the only engineer to receive the Gairdner Foundation InternationalAward; 72 recipients of this award have subsequentlyr e c e ived a Nobel Prize. Among numerous other awa r d sLanger has received are the Dickson Prize for Science(2002), Heinz Award for Te ch n o l o g y, Economy andE m p l oyment (2003), the Harvey Prize (2003), the Jo h nFritz Award (2003) (given previously to inventors such asThomas Edison and Orville Wright), the General MotorsKettering Prize for Cancer Research (2004), the Dan Dav i dPrize in Materials Science (2005), the A l b a ny MedicalCenter Prize in Medicine and Biomedical Research (2005),the largest prize in the U.S. for medical research, inductioninto the National Inventors Hall of Fame (2006), the MaxP l a n ck Research Award (2008) and the Prince of A s t u r i a sAward for Te chnical and Scientific Research (2008). In
TERMIS- NA AWARD PROGRAM • 2011 AWARDEES
(Continued on following page)
1998, he received the Lemelson-MIT prize, the wo r l d ’slargest prize for invention for being “one of history’s mostprolific inventors in medicine.” In 1989 Dr. Langer wa selected to the Institute of Medicine of the NationalA c a d e my of Sciences, and in 1992 he was elected to boththe National A c a d e my of Engineering and to the NationalA c a d e my of Sciences. He is one of very few people eve relected to all three United States National Academies and the youngest in history (at age 43) to ever receive this distinction.
Forbes Magazine (1999) and Bio Wo r l d (1990) havenamed Dr. Langer as one of the 25 most important i n d ividuals in biotechnology in the world. D i s c ove rM a g a z i n e (2002) named him as one of the 20 most important people in this area. Forbes Magazine ( 2 0 0 2 )selected Dr. Langer as one of the 15 innovators wo r l dwide who will reinvent our future. Time Magazine a n dCNN (2001) named Dr. Langer as one of the 100 mostimportant people in America and one of the 18 top peoplein science or medicine in America (America’s Best).Pa rade Magazine (2004) selected Dr. Langer as one of 6“Heroes whose research may save your life.” Dr. Langerhas received honorary doctorates from Harvard Unive r s i t y,the Mt. Sinai School of Medicine, Yale Unive r s i t y, the ETH(Switzerland), the Te chnion (Israel), the Hebrew Unive r s i t yof Jerusalem (Israel), the Universite Catholique de Louva i n(Belgium), Rensselaer Po l y t e chnic Institute, Wi l l a m e t t eU n ive r s i t y, the University of Liverpool (England), BatesCollege, the University of Nottingham (England), A l b a nyMedical College, Pe n n s y l vania State Unive r s i t y,Northwestern Unive r s i t y, Uppsala University (Sweden) andthe University of California – San Francisco Medal. Her e c e ived his Bach e l o r ’s Degree from Cornell University in1970 and his Sc.D. from the Massachusetts Institute ofTe chnology in 1974, both in Chemical Engineering.
SENIOR SCIENTIST AWA R D :D avid J. Mooney D r. David Mooney is a pioneer in the tissue engineering and biomaterials fields, and has also made significant impact through his professional and educational activities and the translation of inventions from his labora t o r yto industry. His work is helping to move tissue engineering from its empirical beginnings to a discipline based on fundamental scientific and engineering principles. He has published extensive l y, with over 14,000 citations and an h-index of 76. On the translational front, twelve companies have taken licenses to patents on wh i ch Dr. Mooney is ani nve n t o r, and biomaterials developed in his laboratory for tissue engineering and regenera t ive medicine have been successfully commerc i a l i z e d .
The Mooney laboratory has repeatedly identified key roadblocks in the tissue engineering and regenera t ive medicinefield, and subsequently developed new technologies that bypass or hurdle these roadblocks. One of his most significantr e s e a rch contributions to date is the invention of polymers that allow single or sequential delivery of growth factors tobuild highly functional new networks of blood vessels (angiogenesis on demand) (Nature Biotechnol. 1 7 : 5 5 1 - 5 5 4 , 1 9 9 9 ;Nature Biotechnol. 19:1029-1034, 2001). Vascularization is one of the greatest challenges in tissue engineering, and Dr.Mooney has pioneered approaches to create highly functional blood vessels that have been demonstrated to prevent limbloss and alleviate complications of coronary artery disease in animal models, and more broadly to enhance the surviva land function of various transplanted stem cells. This approach has been shown to have particular promise in promotingbone and skeletal muscle regeneration. His laboratory has also developed hydrogels to transplant cells wh i ch allow oneto both direct the organization of these cells into complex multicellular structures (e.g., growth-plate like structures; P NA S
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99:12025-12030, 2002), and to control their stage of differentiation and participation in regeneration (P NA S105:14347-52, 2008). He has also made seve ral important research contributions at the intersection ofm e chanics and biology, including (1) the identification ofthe role of cyclic strain in growth factor transport (N a t u r e408:998-1000, 2000), (2) the impact of adhesion substra t em e chanical properties on plasmid DNA uptake in localgene thera py (Nature Materials 4(6):460-4, 2005), (3) therole of specific adhesion ligands in the response of engineered tissues to external strain (Nature Biotech n o l .,17:979-983, 1999), and (4) the control of stem cell fate in3D culture by substrate elastic modulus (Nature Materials.9(6):518-26, 2010). Quite recently, his laboratory hasd e veloped materials that can program and reprogram theimmune system (Nature Materials. 8(2):151-8, 2009). Th i shas led to the first demonstration that a cancer vaccine cancause regression of established skin tumors in mice(Science Trans. Res. 1(8):8-19, 2009), and this approach of using biomaterials to modulate the immune systems h ows promise in addressing the chronic inflammationunderlying many diseases in wh i ch tissue engineerings t rategies are currently being applied. A common theme to this work is the discovery of fundamental biological
TERMIS- NA AWARD PROGRAM • 2011 AWARDEES
(Continued from previous page) principles to guide tissue regeneration, and the subsequentd e velopment of cell instructive materials based on theseprinciples that precisely regulate the gene expression ofcell populations within tissues via temporal and spatialcontrol of both chemical and mechanical cues.
D r. Mooney was a Founding Member of the Ti s s u eEngineering Society (the precursor to TERMIS), served asits Scientific Director, and Chaired the Program Committeefor one of its first International Meetings (Orlando, FL2000). He has served on the Board of Governors of TERMIS, and on the Editorial Board and Executive EditorialBoard of Tissue Engineering. He developed one of the firstcourses in Tissue Engineering, and has taught this courseto thousands of students at Michigan and Harvard over the past 17 years. He has been an active mentor to tissueengineering Ph.D. students and post-doctoral fellows (> 70 PhD students and post-docs mentored; 17 currentlyh ave tenured or tenure-tra ck appointments). His contributions have led a variety of honors, including election to the National A c a d e my of Engineering, theSociety for Biomaterials Clemson Award, IADRDistinguished Scientist Award, NIH MERIT Award, NatureB i o t e chnology SciCafe Award, and Einstein Visiting Fe l l ow(Einstein Fo u n d a t i o n - B e r l i n ) .
YOUNG INVESTIGATOR AWA R D :F. Kurtis Kasper presently holds an appointment as Faculty Fe l l ow in the Department of Bioengineering at Rice Unive r s i t y.He received his B.S. in Biomedical Engineering from Case Western Reserve University in Cleveland, Ohio (1999) with anemphasis on polymeric biomaterials. From 1997-1999, he studied the effects of myxomatous tissue changes on them e chanical properties of the mitral heart va l ve at the Cleveland Clinic Foundation. He earned his Ph.D. inBioengineering in 2006 from Rice Unive r s i t y. In conjunction with his graduate work, Kasper served as a visitingr e s e a rcher over the summer of 2004 at the Institute for Frontier Medical Sciences at Kyoto University in Kyoto, Ja p a n .K a s p e r ’s doctoral research invo l ved the application of polymeric biomaterials toward non-viral gene delivery for bone tissue engineering. His postdoctoral training at Rice University (2006-2008) focused upon the application of novel biomaterials and adult-derived stem cell culture techniques for the generation of hematopoietic bone.
K a s p e r ’s research focuses upon the development and evaluation of novel materials and approaches for the r e g e n e ration of orthopaedic tissues, including bone and cartilage. He is the author of over a dozen publications and hascontributed significantly to the preparation of an undergraduate level textbook focused on biomaterials (Biomaterials: Th eIntersection of Biology and Materials Science, Pearson Prentice Hall, 2008).
Kasper is a member of the American Society for Engineering Education (ASEE), the Tissue Engineering Internationaland Regenera t ive Medicine Society (TERMIS), the Biomedical Engineering Society (BMES), the Society for Biomaterials(SFB), and the Controlled Release Society (CRS). He has been recognized with various fellowships and awards, includinga Nanobiology Training Fe l l owship through the W.M. Ke ck Center for Interdisciplinary Bioscience Training of the GulfCoast Consortia (2007), the Sallyport Award for University and Community Service (Rice Unive r s i t y, 2006), an NSFI n t e g ra t ive Graduate Education and Research Traineeship (IGERT) (2001-2003), and the Jose Ricardo Alcala MemorialAward for Biomedical Engineering Research (1999). Apart from his professional service, Kasper remains actively engagedwith Rice University and the greater community through various leadership positions and volunteer projects.
M A RY ANN LIEBERT, INC. OUTSTANDING STUDENT AWA R D :Jessica DeQuach r e c e ived her B.S. in Biomedical Engineering from Case Western Reserve Unive r s i t y. She then went toUC San Diego to earn her PhD in Bioengineering, where she is a member of the Biomaterials & Regenera t ive MedicineLab run by Dr. Karen Christman. Jessica is developing tissue specific matrices for treating ischemia in the brain, skeletalmuscle, and heart as well as cell culture coatings for stem cell and progenitor differentiation. Jessica also received the 2011 Siebel Scholar awa r d .
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CONFERENCE SPONSORS
ORGANIZER:
The Tissue Engineering & Regenerative Medicine International Society (TERMIS) brings together theinternational community of persons engaged or interested in the field of tissue engineering and regenerative medicine and promotes education and research within the field of tissue engineering and
regenerative medicine through regular meetings, publications and other forms of communication. The Society alsoserves as an international forum to promote the informed discussion of challenges and therapeutic benefits of the application of tissue engineering and regenerative medicine technologies. Most importantly, the Society is committed tobringing you closer to key professionals to support your mutual understanding of the field, accelerate your researchin the field and to enable you to contribute to the ultimate care of patients in this very important way. To affect thisinterchange of information, the Society has endorsed the journal, Tissue Engineering, Parts A, B and C, as its official publication and has negotiated a reduced subscription rate for members. www.termis.org
PLATINUM SPONSOR:
Kinetic Concepts, Inc. is a leading global medical technology company devoted to the discovery anddevelopment of innovative, high-technology therapies and products for the tissue regeneration, wound
care and therapeutic support system markets. Headquartered in San Antonio, Texas, the Company employs 7,100 peopleand brings its healing therapies to serve the needs of clinicians and patients around the world. www.kci1.com
Celgene is a global biopharmaceutical companycommitted to delivering truly innovative and life-changingtherapies to patients. The Cellular Therapeutics Divisionof Celgene is committed to the discovery, developmentand commercialization of novel human cell and tissuebased therapeutic products for the treatment of severeand debilitating diseases. http://www.celgene.com/
Covidien is a leading global healthcare products company that creates innovative medical solutions forbetter patient outcomes and delivers value through clinical leadership and excellence. Covidien manufactures, distributes and services a diverse range of industry-leading product lines in three segments:Medical Devices, Pharmaceuticals and Medical Supplies.With 2010 revenue of $10.4 billion, Covidien hasapproximately 42,000 employees worldwide in morethan 60 countries, and its products are sold in over 140countries. Please visit www.covidien.com to learn moreabout our business.
Elsevier Science & Technology Books has provided award-winning education resourcesto researchers worldwide and is pleased topublish Principles of Regenerative Medicine,
2nd edition, by Atala, Lanza, Thomson and Nerem. It isthe first book of its kind to offer an advanced understand-ing of the latest technologies in regenerative medicine.http://www.elsevierdirect.com/stemcells
The Wake Forest Institute for Regenerative Medicine’smission is to improve patients’ lives through regenerativemedicine therapies. Its scientists engineered the first laboratory-grown organs to be implanted into humans.The team currently is working to engineer more than 30 different organs and tissues and to develop cell therapies to restore organ function. http://www.wakehealth.edu/wfirm/
SILVER SPONSORS:
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CONFERENCE SPONSORS (Continued)
HOST AND CONFERENCE SPONSOR:
As a leading research university with a distinctive commitment to undergraduate education, RiceUniversity aspires to path-breaking research, unsurpassed teaching, and contribution to the bettermentof our world. It seeks to fulfill this mission by cultivating a diverse community of learning and
discovery that produces leaders across the spectrum of human endeavor. Since 2006, Rice has been guided by a 10-point strategic vision in furtherance of its mission.
The university must (1) increase its commitment to research and to raising its research and scholarship profile; (2) provide a holistic undergraduate education that equips its students to make a distinctive impact; (3) strengthen itsgraduate and postdoctoral programs; (4) aggressively foster collaborative relationships with other institutions to leverageits resources; (5) invest in a select number of interdisciplinary endeavors that will enable it to leverage its strengths aswell as those of potential collaborators; (6) continue to invest in its professional schools and seek ways to integrate theirsuccess into the broader university; (7) increase the size of the university; (8) become an international university; (9) provide the spaces and facilities that will cultivate vibrancy and community; and (10) fully engage with the city of Houston. http://www.rice.edu/
PRE-CONFERENCE WORKSHOP SPONSORS:
NovaMatrix, a business unit of FMC BioPolymer, provides well-characterized, ultrapure alginate,water-soluble chitosan salts and hyaluronic acid for use in drug delivery, tissue engineering, cellencapsulation, and medical device applications where functionality and regulatory documentation
are important. Our new NovaMatrix 3-D cell culture system expands research possibilities in regenerative medicine.www.novamatrix.biz
Texas Children’s Hospital is committed to a community of healthy children by providing the finestpediatric patient care, education and research. Renowned worldwide for its expertise and breakthrough developments in clinical care and research, Texas Children’s is nationally ranked in all10 subspecialties in U.S.News & World Report’s list of Best Children’s Hospitals. Texas Children’s alsooperates the nation’s largest primary pediatric care network, with more than 40 offices throughout the
greater Houston community. Texas Children’s has embarked on a $1.5 billion expansion, Vision 2010, which includesthe Jan and Dan Duncan Neurological Research Institute, a comprehensive obstetrics facility focusing on high-risk births and a community hospital in suburban West Houston. For more information on Texas Children’s Hospital, go towww.texaschildrens.org. Get the latest news from Texas Children’s Hospital by visiting the online newsroom and onTwitter at twitter.com/texaschildrens.
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CONFERENCE SPONSORS (Continued)
MEDIA SPONSORS:
Science Translational Medicine promoteshuman health by providing a forum forcommunicating the latest biomedical
research findings from translational researchers in allareas of medicine. The journal strives to bridge the gapbetween the rich foundation of basic science and theneeds of clinical medicine, facilitating informationexchange in both directions. http://stm.sciencemag.org/
The International Journal of Artificial Organs(IJAO) is the Official Journal of the EuropeanSociety for Artificial Organs. IJAO publishesmonthly peer-reviewed research, clinical andexperimental contributions to the fields of
artificial, bioartificial and tissue-engineered organs.IJAO’s mission is to foster the development of artificial,
bioartificial, tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of allhuman tissues and organs. www.artificial-organs.com
IOP Publishing is an international, not-for-profit,
learned society publisher. We are a world leader in scientific publishing and the electronic dissemination of peer-reviewed scientific research. Stop by our table for a sample copy of one of our renowned journals, such asBiomedical Materials (www.iopscience.iop.org/bmm)and Biofabrication (www.iopscience.iop.org/bf).
Tissue Engineering is the premier biomedical journal
merging engineering and life sciences for tissue development. Part A provides fundamental research andunderstanding of structure-function relationships. Part B,Reviews publishes critical discussion and analyses toassess progression in the field. Part C Methods presentsprocedures and protocols to translate research into future clinical applications. www.liebertpub.com/products/product.aspx?pid=315
Stem Cell Research & Therapy is aninternational peer-reviewed journal
publishing open access research articles of outstandingquality with a special emphasis on basic, translational,and clinical research into stem cell therapeutics. Edited by Rocky Tuan and Timothy O’Brien, the journal’s firstImpact Factor is due in 2012. http://stemcellres.com
Wiley-Blackwell is theinternational scientific,
technical, medical and scholarly publishing business ofJohn Wiley & Sons, with strengths in every major academic and professional field and partnerships withmany of the world’s leading societies. For more information, please visit www.wileyblackwell.comor http://onlinelibrary.wiley.com/
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EXHIBITORS
AABB is a leading cellular therapy (CT)organization with 60+ years of experienceproviding professional development, standard setting and accreditation.
Expand your professional network and experiencethrough participation in the rapidly growing CT Sectionincluding a group for novel therapies and product development. AABB members can now add theRegenerative Medicine journal to their benefits. Research grants available up to $75,000.http://www.aabb.org
AFIRM is a multi-institutional, interdisciplinary network working to
develop advanced treatment options for our severelywounded Warriors. AFIRM is designed to speed the delivery of regenerative medicine therapies to treat ourmost severely injured Warriors from around the world, in particular those supporting operations in Iraq andAfghanistan. www.afirm.mil
Biomomentum specializes in providingsolutions for the biomechanical
evaluation of biomaterials and cartilage. It develops andcommercializes: Arthro-BST, an arthroscopic probe developed for precise non-destructive assessment of articular cartilage, which calculates a quantitativeparameter reflecting its biochemical composition andload-bearing properties; and Mach-1, a micromechanicaltester capable of performing compression, tension, shearand torsion tests for precise characterization and mechanical stimulation of cartilage and other soft tissueor materials. Biomomentum also offers biomechanicaltesting services using its unique instrumentation.www.biomomentum.com
BioSpherix will be exhibiting the XvivoSystem, world’s first and only barrier isolator optimizedfor cells. Economical and practical alternative to cleanrooms for cGMP compliant production of humancells for clinical use. Get better contamination control,better process control, better quality control, better pocketbook control. Stop by the BioSpherix booth.http://www.biospherix.com/
Bose Corporation manufactures the ElectroForce® test instruments
using proprietary linear motor technology. Bose offersinstruments for the characterization of soft tissues, biomaterials, bones and a variety of medical devicesincluding stents, endovascular grafts, and spinal implants.The BioDynamicTM test instruments provide characteriza-tion and stimulation of tissue constructs in a biologicalenvironment. www.bose-electroforce.com
Celgene is a global biopharmaceutical company committed to delivering truly innovative and life-changing therapies to
patients. The Cellular Therapeutics Division of Celgene is committed to the discovery, development and commercialization of novel human cell and tissue basedtherapeutic products for the treatment of severe anddebilitating diseases. http://www.celgene.com/
CellGenix has been a worldwideleader with the highest quality ex vivo
reagents available for clinical cellular therapies for over16 years. CellGenix manufactures both high quality GMPand research grade cytokines and GMP cell culture medium for use in ex-vivo dendritic, stem, NK, MSC, and T cell culture protocols. CellGenix’s focus is on highquality, individualized, ex-vivo, cell and gene therapeutics. Our continued mission to provide improvedproducts and processes that enables patients to livelonger lives. www.cellgenix.com
Crescent Chemical Company is theUS distributor for Serva Collagenase
NB6 GMP which has been optimized for isolation andpassaging of cells designated for transplantation intohumans. It is sterile and ready for immediate use, meetsstringent safety standards such as TSE safety certificationand very low endotoxin levels.www.crescentchemical.com
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DaVINCI Biomedical Research is a preclinical CRO specializing in regenerativeapplications performing GLP & Non-GLP
animal studies for FDA approval. We provide expertise inanimal models for scaffold applications (organ, vessel,tendon, muscle), wound, orthopeadic (bone, joint, cranial, maxillofacial, spine), cardiovascular (valve, MI,CHF, vessel/artery), and much more. Our services includehigh level surgical skills, mechanical engineering & testing via Instron System, imaging, and a large array ofanimal models (Non-human primates, canine, porcine,ovine, caprine, bovine, and rodents). Check out our newwebsite at www.davincibiomed.com.
Elsevier Science & Technology Books has provided award-winning education resources to researchers worldwide and is pleased topublish Principles of Regenerative Medicine,
2nd edition, by Atala, Lanza, Thomson and Nerem. It isthe first book of its kind to offer an advanced understand-ing of the latest technologies in regenerative medicine.http://www.elsevierdirect.com/stemcells
IEEE Engineering in Medicine and Biology Society (EMBS) is the world’s largest international society of biomedical engineers. EMBS members are focused on the development and application of engineering conceptsand methods to provide new solutions to biological, medical and health care problems. http://embs.org/
Fisher BioServices (FBS), a unit of Thermo FisherScientific, is a professional cell therapy services businessoperating under GMP and GTP guidelines. With locationsaround the world, FBS is committed to providingbiorepository, logistics infrastructure and clinical trialservices to the cell therapy industry. Our global facilitiesand capabilities provide integrated solutions from collection site or CMO to repository or clinical site.Services include biorepository, biobanking, laboratoryservices, cell or specimen collection kits and distribution,cold chain and ultra cold chain management.www.fisherbioservices.com
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Glycosan BioSystems’ cGMP-quality hydrogels connectcell culture with cell therapy. The
hydrogels (HyStem) are made from naturally occurringhyaluronan. They are also customizable and injectable,providing a lifelike cellular microenvironment for neuraland orthopedic applications. www.glycosan.com
Harvest manufactures the first-of-its-kind SmartPReP 2 Cell ConcentrationSystem with BMAC (Bone Marrow
Aspirate Concentrate) procedure packs for ConcentratingAutologous Adult Stem Cells, and APC+ procedure packsfor Concentrating Platelets—both at point-of-care in only15 minutes, and both with small volume 30mL kits nowavailable. In minutes, SmartPReP produces predictableconcentrates enriched with multiple cells and GrowthFactors. www.harvesttech.com
IOP Publishing is an interna-tional, not-for-profit, learned
society publisher. We are a world leader in scientific publishing and the electronic dissemination of peer-reviewed scientific research. Stop by our table for asample copy of one of our renowned journals, such asBiomedical Materials (www.iopscience.iop.org/bmm)and Biofabrication (www.iopscience.iop.org/bf).
JMS Co., Ltd., one of the largest Japanese medical device companies, is
presenting CELLAID® a new medical device for serumcollection. CELLAID® is specially designed to preparegrowth-factor-rich human serum within 1 hr. We will also display biodegradable films, tubing and spongesprocessed from our in-house made P(LA/CL) copolymer.www.jms.cc/english/index.html
Kaneka Corporation is a producer of chemical products including resins,
pharmaceutical intermediaries, food supplements, synthetic fibers, and fine chemicals. The Innovate Bone Marrow MSC separation device harvests mesenchymal stem cell (MSC) via a filter.http://kaneka-cellseparation.jp/msc/english
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Lifecore Biomedical, LLC, specializesin aseptic filling and manufacturing of hyaluronan by fermentation and
recently introduced CorgelTM BioHydrogel kits to theresearch community. Hyaluronan is used and Corgel is being evaluated in applications that range from ophthalmology and tissue engineering to orthopedics,wound healing and aesthetics, along with several others.www.lifecore.com
The McGowan Institutefor Regenerative
Medicine, part of the University of Pittsburgh and UPMC,serves as a base for scientists and clinical faculty workingin tissue engineering and biomaterials, cellular therapies,and medical devices and artificial organs. McGowan’smission is the development of innovative clinical proto-cols and the commercial transfer of new technologies.www.mcgowan.pitt.edu
Nano3D Biosciences, Inc. (n3D) seeks tocreate the industry leading standard for 3-dimensional cell culturing solutions. Using
a proprietary combination of nanoparticle-based reagentsand magnetic fields, n3D created a simple device to magnetically levitate cells to enable 3-dimensional tissuegrowth. n3D’s “Bio-Assembler” succeeds in offering an in vitro device that mimics the in vivo environment withmany major advantages over existing cell culturing methods. This breakthrough technology will directlyaddress core needs in life sciences, drug discovery,toxicology, and regenerative medicine. www.n3dbio.com
NovaMatrix, a business unit of FMCBioPolymer, provides well-character-ized, ultrapure alginate, water-
soluble chitosan salts and hyaluronic acid for use in drug delivery, tissue engineering, cell encapsulation, and medical device applications where functionality and regulatory documentation are important. Our newNovaMatrix 3-D cell culture system expands researchpossibilities in regenerative medicine.www.novamatrix.biz
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Organovo is a regenerativemedicine company focused on
delivering breakthrough three dimensional biology capabilities to create tissue on demand for research andsurgical applications. The NovoGen MMX Bioprinter is at the forefront of sculpting three dimensional and functional tissue consisting of multiple cell types and biomaterials. Visit us at www.organovo.com.
Using our proprietary expertise inmicromachining and knitting, Proxy
Biomedical designs, develops, and manufactures industryleading absorbable and non-absorbable tissue engineering biomaterials and delivery systems. The product platforms combine minimally invasive surgerytechniques with optimal tissue regeneration. Advancedbiomaterials, tissue engineering scaffolds, medical textilesand delivery systems produced with state-of-the-art materials and processes will be on display.www.proxybiomedical.com
RESBIO is an NIH-funded national biomedical technology resource thatdevelops integrated multidisciplinary state-of-the-art technologies tailored to
accelerate biomaterials research. The booth will showcasehigh-throughput polymeric biomaterial synthesis, high-throughput cell-material interaction characterization,mechanobiology research, confocal microscopy for earlydetermination of stem cell lineage commitment, andcomputational modeling for biomaterial optimization.http://www.njbiomaterials.org/web/index.php?p=resbio
SANYO Biomedical Solutions is a global, leading provider of energy,environment, and lifestyle applications
with laboratory equipment for pharmaceutical, life science and biotechnology applications. Product linesinclude space-efficient VIP® ultra-low temperature freezers, cryogenic freezers, pharmaceutical and medicalrefrigerators, cell culture incubators, plant growth chambers, and portable autoclave. For the GMP compliant processing and manufacturing of tissue and cell therapies, SANYO Biomedical Solutions offers the innovative Cell Processing Work Station.www.sanyobiomedical.com
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Synthecon Inc. provides cellculture solutions to researchers
involved in tissue engineering, stem cell research, matrixdevelopment, 3D cell culture, and tissue modeling fordrug discovery or infectious disease studies. The RotaryCell Culture SystemTM (RCCS) platform technologyaffords a unique gentle environment for the growth andexpansion of cells in a 3D architecture. Additionally theRCCS allows for the co-culture of multiple cell typeswhich assemble into three-dimensional tissue models.www.synthecon.com
Nanofibre Scaffolds for 3D Cell Culture andRegenerative Medicine - from bench to bedsideWe manufacture reproducible electrospun scaffolds for laboratory use and partner with our customers todevelop cell-based implantable devices for regenerativemedicine. Our scaffolds are made from FDA approvedpolymers to facilitate translation from lab to clinic.www.electrospinning.co.uk
ThermoGenesis® developsand manufactures
innovative and enabling technologies for Stem CellProcessing and Cryopreservation. —- Res-QTM60 BMCpoint-of-care system- concentrates bone marrow in 15minutes. —-BioArchive® System- fully robotic system for cryo-preservation and archiving of stem cells. —-AutoXpressTM product platform- isolates and concentrates stem cells from bone marrow aspirate or cord blood. www.thermogenesis.com
EXHIBITORS (Continued)
Tissue Growth Technologies, aleading supplier of bioreactors formechanically-stimulated 3D tissue
growth, offers products ranging from modular componentsto fully integrated systems. Chambers impart computercontrolled mechanical forces to developing tissues in a real-time monitored, incubator friendly, sterile environment. TGT products allow researchers to designexperiments, not instruments. www.tissuegrowth.com
Veterinary Transplant Services, Inc. (VTS) provides custom animal tissue procurement and processing for pre-clinical trials, R&D, product testing, and more.Working with a professional animal tissue bank for youranimal tissue needs will provide you with clinical-qualityanimal tissue. Only tissue graft that has been processedaccording to current Good Tissue Practices (cGTP) and tissue banking industry standards provides the level ofconsistency and predictability of tissue graft used in aclinical setting. Working with animal tissue that has notbeen processed to tissue banking industry standards mayweaken or jeopardize your pre-clinical trials, R&D,or product testing outcomes. www.vtsonline.com
The Wake Forest Institute for Regenerative Medicine’smission is to improve patients’ lives through regenerativemedicine therapies. Its scientists engineered the first laboratory-grown organs to be implanted into humans.The team currently is working to engineer more than 30different organs and tissues and to develop cell therapiesto restore organ function.http://www.wakehealth.edu/wfirm/
TABLE-TOP EXHIBIT DISPLAYS:
Tissue Engineering is the premier biomedical journal merging engineering and life sciencesfor tissue development. Part A provides fundamental research and understanding of
structure-function relationships. Part B, Reviews publishes critical discussion and analyses to assess progression in thefield. Part C Methods presents procedures and protocols to translate research into future clinical applications.www.liebertpub.com/products/product.aspx?pid=315
Wiley-Blackwell is the international scientific, technical, medical and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and
professional field and partnerships with many of the world’s leading societies. For more information, please visit www.wileyblackwell.com or http://onlinelibrary.wiley.com/
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EXHIBITORS FLOOR PLAN AND BOOTH LOCATION
AABB: 203AFIRM: 702Biomomentum: 406BioSpherix: 207Bose: 302Celgene: 303CellGenix: 507Crescent Chemicals: 501DaVINCI Biomedical Research Products: 306Elsevier: 407Fisher BioServices: 301Glycosan Biosystems: 101Harvest Technologies Corp: 500IEEE Engineering in Medicine & Biology Society: 403IOP Publishing: 307JMS: 200
Kaneka: 201Lifecore Biomedical: 506McGowan Institute for Regenerative Medicine: 603n3D Biosciences: 502NovaMatrix: 400Organovo: 300Proxy Biomedical: 103RESBIO - NIH Funded Biomedical Technology
Resource: 503SANYO: 606Synthecon: 402The Electrospinning Co: 600ThermoGenesis Corp: 401Tissue Growth Technologies: 202Veterinary Transplant Services: 107WFIRM: 700
OPENING RECEPTIONSunday, December 11, 2011 • 6:30 - 9:00 pm • Located in the Exhibit Hall in the Grand Ballroom
Each attendee is required to check-in at the 2011 TERMIS NA Conference registration desk.Photo ID is required at check-in. The registration desk will be open at the following times:
Sunday, December 11 from 7:00am - 7:00pm • Monday, December 12 from 7:00am - 5:00pmTuesday, December 13 from 7:00am - 5:00pm • Wednesday, December 14 from 7:00am – Noon
Exhibit hours / Poster viewing hours:Sunday, December 11, 2011 6:30 PM - 9:00 PM - Welcome reception held in the Exhibit Hall
Monday, December 12, 2011 9:30 AM - 10:00 AM • 11:30 AM - 1:00 PM • 2:30 PM - 3:00 PM • 4:30 PM - 6:00 PM Tuesday, December 13, 2011 9:30 AM - 10:00 AM • 11:30 AM - 1:00 PM • 2:30 PM - 3:00 PM • 4:30 PM - 6:00 PM
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