Bone

Investigatethe economyof MPIStannousDiphosphonateYoucan useupto8mlof5to l5mCi99mTc ineach vial. The reagent is usable for six hoursafter labeling.Youalso haveno delivery charges when youorder MPIStannousDiphosphonatewith anyother MPIproducts.Ask your Medi-Physicsrepresentativeaboutour economical, reliabledelivery procedures

.or call toll free:(800)227-0483—OutsideCalifornia(800) 772-2446—InsideCalifornia

MPIStannousDiphosphonatetargets areas ofdiagnostic significance. Its reliability ismagnifiedwith:

RapidBloodClearance.TheP-C-Pbondofdiphosphonateresistshydrolysis;clears thekidneys rapidly.Optimumimaging time is intwo to four hours.

IncreasedStability.Ascorbicacidwithinthereagentaids in maintainingtin in its reducedstate.The @mTcpertechnetatestayswhere itbelongs.. .tagged to the reagent.

OptimumTinLevels.TheSn(ll)levelprovides high labelingefficiency,with minimuminterferencewith subsequentbrain scans. c.

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For complete Information consult the p.ckage Insrt, a summary of which follows:MPI Stannous DlphosphonatsTechnstlum Tc 99m Etldronate Kft-DlagnostlcDESCRIPTiON: Each ampul contains a total of 1.54 mg of the sodium salt of should precede bone imaging procedures. Technetium Tc 99m etidronate shouldetidronate, 0.42 mg stannous chloride, and 3.87 mg ascorbic acid in a 2.2-mi be formulated, following aseptic procedures, within 6 hours prior to clinical use.sterile, pyrogen-free aqueous solution. Hydrochloric ac,d and/or sodium hydroxtde ADVERSE REACTIONS: Seven suspected reactions to technetium Tc 99mmay have been added to adjust the pH to 2.5-5.0. The solution is under a nitrogen etidronate were reported in more than 22,500 clinical reports. There were twoatmosphere. A complex is formed with the addition to the reagent of sterile, instances each of headaches and allergic reactions and one each of vomiting,pyrogen-free sodium pertechnetate Ic 99m in isotonic saline. meumatoi@arthritis flare-up, and skin rashINDICATIONS: TechnetiumTc 99m etidronateis usedas a boneimagingagent to @SAGEAND ADMINISTRATION: The suggested adult dose is 5-15 mCidelineate areas of altered osteogenesis. administered by slow IV. injection. Do not administer more than 2.0 ml of unlabeledCONTRAINDICATIONS: None known. reagent per patient. Measure the patient dose with a suilable radioactivityWARNINGS: This radiopharmaceuticalshould not be administeredto children, calibrationsystemimmediatelypriorto administration.Scanningpost-injectionispregnant women, or nursing mothers unless the expected benefit outweighs the optimal at 2-4 hours.potential risk. Radiopharmaceutical examinations of women of childbearing Radiopharmaceuticals should be used only by physicians who are qualified bycapability should be performed during the first few days following the onset of specific training in the safe use and handling of radionuclides and who have beenmenses. approved by the appropriate government agency.

PRECAUTIONS: To minimizeradiationdose to the bladder, the patientshouldbe HOW SUPPLIED: Each kit package contains five sealed glass ampuls asencouraged to drink fluids and void when the examination is completed and as described above, five sterile, pyrogen-free mixing vials, five each of mixing-vialoften thereafter as possible for the next 4-6 hours. Where feasible, brain scans and record labels and one package insert. Store at 5@-8@C;protect from light.

II1111111II111111UllilIllIlI011110111111@31CX-T23-.FB2L

SeekerMPISTANNOUSDIPHOSPHONATE(TECHNETIUMTo99mETIDRONATEKIT)CON@STENTLYSEEKSBONEANDBONELESKJNS.

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Here isawhole-bodypositron imagingsystem—nowavailablefromTheCyclotronCorporation—whichfullyexploits the uniquecapabilitiesof annihilationcoincidencedetection in conjunction with short-lived,positronemitting radionuclidessuchas“C,‘3N,and‘50—isotopeswhichcanreplacetheir stablecounterpartsincompoundsthatenterdirectlyintoalllife processes.

Designatedthe Model4200,it isthe one systemwith the flexibilityperformance,andoperationalfeaturesrequiredforstudiesrangingfrombasicmedicalresearchtoclinicaldiagnoses,andtreatmentevaluation.

Exceptionalutilityandperformancecharacterizethisnewsystem.Itiscapableofbothmultiplanelateraltomographic imagingandtransverseaxialtomography.TheModel4200 RsitronCameraoffers highsensitivity,resolu

tion, andcount ratecapability in allmodes.In the lateral imagingmodehigh-speeddynamicstudiesor detailedstaticstudiesmaybedisplayedtomographicallyon selectedfocal planes.InthetransverseCI mode,acylindrical volume33 cm by 33 cm maybecompletelycharacterizedin3dimensionsin contiguousor overlappingslicesinonescan.Inaddition,accurate,quantitativeimagesmaybeobtainedbymeansofatransmissionscanusinganaccessoryfloodsourcewhichpermitscorrection for attenuationeffectsinthesubject.

TheSystemiscomplete in allrespectsincludingadedicatedcomputerwith requiredsoftware.

All dataacquisition,imageprocessinganddisplay,pluspatientfilekeepingare underthe control of adigital computersystemwhich iswidely knownandacceptedin nuclearmedicalappli

cations—DigitalEquipmentCorporation@Gamma11T@

Any medicaltechnologistcanmasterthe simple,interactiveoperating format acomputerspecialist is notrequired.Forthe sophisticateduser,the complete,stand-alonecapabilityofthe PDP11/34isavailable.Includedwith the computerwithout additionalcostaresoftware-supportandprogramdevelopmenttoolsavailableundertheRT-11operatingsystemincludingFortran,Basic@and Macroassemblylanguages.

TheCyclotronCorporationalsooffers a full line of compactcyclotronsystemswhichareidealforproductionofshort-livedpositronemittingradionuclides,

FormoreinformationontheModel4200 FksitronCameraSystemandcompactcyclotron systems,completeandmailthe coupon.

A remarkable advancein Nuclear Scintigraph3

Functional amPhysiological Jrnacjim

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THE

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Youare entering a remarkableera of diagnostic advancement.Instead of being limited to asingle imaging method, you willtake advantage of manytechniques, choosing them tomeetyourspecific diagnosticcriteri a and the cond ition ofyour patient.

Searle is helping shapethis eraof advancement. Overthe pastdecade. guided by your needs.we have developed sophisticated nuclear imaging instruments to a high degree of performance. Now, the knowledgegained during that time is beingapplied to the creation of instrumentation inthefieldsofultrasound and CTscanning.

What Searle developed yesterday in nuclear imaging. themedical community relies ontoday. And today we are planning significant advances inultrasonic, CT,and nuclear imaging. Tomorrow is in view.

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IMAGING:TheLivingArt

=Searle Radiographics Inc.SubsidiaryofG. D. Searle&Co.

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Northwestern Memorial Hospitalhas put a new 91-tube image maker to work.

The Raytheon CamerayXL9l.Northwestern Memorial Hospital is a major midwestern teaching hospital associated with Northwestern

University. The busy nuclear medicine section is using the Raytheon Cameray XL-91 gamma camera.Cameray XL-91 was specifically designed to give superior quality images. In fact, the Cameray XL-91

may be the ultimate medical gamma camera. It gives the widest undistorted field of view available from anygamma camera. 16½inches.

Image uniformity also is no longer a problem with Cameray XL-9L Its exclusive Autocomp CircUitryprovides ±2% uniformity . . . automatically. Autocomp contains four memories . . . allowing users to calibrateto four different isotopes or collimators.

At Northwestern Memorial, Cameray XL-91 is being used each working day for a variety of clinicalstudies and is producing clinicallyuseful images very rapidly. Hospital authorities are particularly pleased withthe speed at which Cameray XL-91 was placed on-line after delivery as well as how qUicklytechnicians wereable to master its operation.

Get more details on Cameray XL-91 by phoning or writing today. Raytheon Company, MedicalElectronics, 70 Ryan Street, Stamford, Corn. 06907. Telephone 800-243-9058.

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4

New England NuclearRadiopharmaceutical DivisionAtomlight Place, North Billerica, Mass. 01862Telephone 61 7-667-9531Los Angeles 213-321-3311

CANADA NE.N Canid,i Ltd . 45.3 40th Avenue. Lihine. One. H7T 3C9. Telephone 514-636-4971. Telex: 05-821808LUROP@ NEN Clierrc,ls CriihH. D-6072 Dreieuh. W. G€.'rrnany.Danleistrasse 23. Postfach 401240. Telephone' (061031 85034. Telex 4-17993 NEN D

Thepackageisnew.Thequalityistraditional.

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As always, the strength of Kodak'simaging technology is in radiography.

In Kodak medical xray films, forexample. A variety of films for your spe'cific needs, each designed to provide highfmage quality Films for general radiog.raphy. Films for special imaging technics:duplication, subtraction, spc@filming,photofluorography, and cinefluorography.And many otheis, including Kodak rateearth screens and films and a screenand film for mammography.

In Kodak automatic processois, forexample.The 90-second high•volumeKodak RP X-Omat processoi modelM6A-N,and the smaller 150-second KodakRP XsOmat processoi; model M7A, thatuses tap water to wash films. Both can useKodak's carefully formulated chemicalsthat offer pOtential economies throughlower replenishment rates.

ln KOdak X.Omatic cassettes, for example. Durable, lightweight, easy to use.

And for the changing needs of thenew wodd of diagnostics, Kodak offersfilms for recordingthe informationgen•erated by these new technics. Films fornuclear medicine . . . for recording multipie, single, or dynamic images . . .with single and double emulsions . . .wlth spectralsensftivitles compatible with cathode-raytube displays. Films for CT anning...for ultrasound . . . for thennography thatcan capture a wide range of gray tones.

For more infoimation, contact yourx-ray products dealei@Or write: EastmanKodak Company, Dept. 740-B, RochesteiNew York 14650.

TURNINGENERGYIN@@AGES

RADIOGRAPHY.COMPUTERIZED TOMOGRAPHYULTRASOUND .PIUCLEARMEDICfl1f ‘ThERMOGRAPHY

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IN 1@DAY@SRADIOGRAPHYAND THENEWDIAGNOSTICMODALITIES,OURIMAGINGPRODUCTSCANBETHESOLUTION1@IDUR IMAGINGPROBLEMS.

Kodak's experience In making quality products for photographic andradiographic Images go@ back many years. And today, that same exper.Use and technology Is being applied to the new diagnostic modalities.Theresult is a combinationof high Imagequalitywith speed,efficiencyand economical performance.

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.TThe New Standard OfExcellence in RadloassayA New Generation Of Integrated Instrument SystemsUsed In Combination With A Swinghead Centrifuge —The Answer To Present And Future RadioassayRequirements Of Clinical, Hospital AndResearch Laboratories

PRIASSample Preparation Unit au@on3@caHysamples.dilutes. adds up to four cooled reagents and asp:@ates reactontubes for counting of bound or free fractons , , , cr both.

PRIASGammaCounting System nnu1@-@roqrarnrnngchanges counting and data reduction condt:'ons for up to sevendifferent assays. without operator intervention. The svsrem prov:descpm. screening functions and ansoers in correo@ed dose units,

PRIASLiquid Scintillation Counting System—stores up to15 different counting programs. The system ndcates efficiency by

external standard ratio or sample channels ratio and computescpm. Optional dpm output is available.

‘ Unique Cassette Sample Changers — each cassette carres

12 counting vials and up to 20 cassettes can be @!acedin a traywhich is remo'.'ab(e from the PRIAS :nstrurnents. The trays fit ntomost commercial refrigerators. permitting convenient incubation andcomplete interchange between the PRIAS instruments. Cassettescan be centrifuged in specially designed adapters.

PositiveSampleID.—built-inthermalprintersforthePRIAS Gamma and Liquid Scintillation Counters provide resultsprinted on Pos-lDent “cards attached to the cassettes. Cards remainwith cassettes throughout each assay step. Additional read-outdevices are available.

For further information, request Bulletin 1226

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PACKARD II\JSTRUMENT COMPANY, INC.

PACKARD INSTRUMENT INTERNATIONAL S.A.

SUBSIDIARIES OF A@V1BAC INDUSTRIES INC.

STANDARDS

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4. Swinghead Rotor Compatibility5. Answers from the Counter

The techno1o@.j,of the SPACsystem is based on sectionalprocessing of the antibodycoating. This Ingeniously simpleidea provides tube-to-tubeantibody uniformity in the SPACDigoxin Test.Tens of thousands of the lowersectIons of SPAC tubes (thereactive sections) are immersedand coated at one time in asolution of antiserum. They arethen sealed to the upper cylinders.As a result, all tubes in a lot areproduced from one batch ofantiserum and have equalcoating on the same reactivesurface area.

Covalent bonding eliminatesdesorplionSince the antiserum is chemicallylinked to the tube surface, therewill be no antibody loss due todesorption. Also, a speciallyselected copolymer material isused in the tube for bondingoptimal quantities of antibody.

The Improvements go beyondU—

1.Mechanicalseparationiseliminated in the SPAC DigoxinTest. You merely pipette,incubate, decant and count.There's no centrifuging, secondincubation, or rinsing; novortexing, aspirating or rotating.

2.Enhancedreactionrate,shortincubation and high countingrate are a result of a stippledsurface area for bonding optimalquantities of antibody.3.There'snopreparationofreagents.4. It is necessary to pipet onlyone micro-quantity. There's nopipetting of antiserum.5.Thetestsystemlendsitselfreadily to sophistIcatedautomation.6. The packaging adds convenience. Tube identification,pipetting, incubating anddecantIng can be done

without removing the tubesfrom the holder shown below.The test, available in 50 and 100-test sizes, offers standards madefrom USP Reference StandardDigoxin. Once you try the test,you'll see how well accuracy,reproducibility, convenience andsimplicity apply to the SPAC system.For information or to arrange anevaluation, call Bob Sheppard at314/895-0404 or contact yourMallinckrodt representative.

I.

INUCLEAR

I RADIOPHARMACEUTICALS1 MALLINCKRODT,INC.

P.O. BOX 5840, ST. LOUIS, MO. 63134MALUNCKRODT CANADA.LTD.

600DELMAR, POINTECLAIRE, @JEBECH9R4A8

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) @i•*k].Test.(Digoxin 1-125Radloimmunoassay Test)The challenge of creating tube-to-tube antibody unifonnityin an RIAsolid phase system has now been answered.

THEsP@c,SYSTEM

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The most advanced data processing systemfor nuclear medicine

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__3(256 x 256) AcquisitIonand Display,introduced over five years ago.

SimultaneousacquisitionanddIsplay.

@,iICift13Programmable color display (256 x256 resolution) with up to 256 programmable levels of color.

Left vntrlcl• sequence of images, constructed from a first passstudy,showing the wall motion and valveaction of the heart. Imagescourtesy of Harbor General Hospital—UCLA, Torrance, California.

Region of Unt•r•stand color coordinated solid line timeactivitycurvesfor cerebral blood flow study.The upper right-handcurves are the anterior cerebral and two carotid curves, thelower right-hand curves are the two carotids, and the lower lefthand curves are the two middle cerebrals.

Themostcomprehensivesoftwarepackage available, including cardIacprogran@ for both fIrst pass andmultiple-gated StUdies.

L@ ICine (movie-like)dlsplay.Completelyupgradable.

3We invite you to visit our displayat the S.N.M.annualmeeting inChicago, Illinois, June 20-23,1977.

CLINICAL DATAPROCESSING SYSTEMS

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Sensor can detectDeep VenousThrombosiswhen it startsand provide dailymonitoring capability

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Indications and UsageSENSOR[radlonuclide-labeled (1251)fibrinogen (human)]is indicated as an aid in the diagnosis of deep-vein thrombosis ofthe legs.A. The SENSOR [radionuclide-labeled (1251)fibrinogen

(human)]test maybe useful for the detectionof thrombi formation in patients undergoing major orthopedic or othersurgical procedures,and in patients with myocardial infarction, pulmonarydisease, malignantdiseaseand other medical conditions known to predispose to thromboembolism.

B. The SENSOR [radionuclide-labeled (1251) fibrinogen(human)] test is indicated in patients with signs and/orsymptomssuggestiveof deep-vein thrombosiswith or without associated pulmonary embolism or in patients withpulmonaryembolism,with or without evidenceof peripheraldeep-vein thrombosis. In patients with established, old or“inactive―thrombi, the test may not be positive if radionuclide-labeled fibrin deposition does not occur in sufficient quantity to allow detection. Its use is not contraindicated in a patient on an anticoagulant regimen.

ContralndicatlonsThe iodides given to block the uptake of 1251by the thyroidgland are contraindicated in patients with a known sensitivitytolodides.

WarningsThis radiopharmaceutical drug product should not be administered to children, to patients who are pregnantor to nursing mothers unless the expected benefits to be gained outweigh the potential risk.

Ideally, examinations using radiopharmaceuticals, especiallythose elective in nature, of a womanof childbearing capabilityshould be performed during the first few (approximately 10)days following the onset of menses.

Extraordinary precautions have been taken In the preparationof SENSOR[radionuclide-labeled (125l)fibrinogen (human)] toeliminate the possible transmission of hepatitis. Nevertheless,the remote risk of hepatitis associated with the administrationof radionuclide-labeled (1251)fibrinogen (human)cannot be entirely eliminated.The finding of viral hepatitis in any patient upto six monthsafter the administration of SENSORshould be reported to Abbott Laboratories.

PrecautIonsCare should be taken to insure minimumradiation exposure byusing the recommendeddose. With blockade of thyroidal uptake of the radioactive iodine, however, repeat injections maybe performed in patients remaining at high risk of venousthrombosis.

There are a numberof clinical circumstances requiring care inthe interpretation of the test results (see Interpretation of theResults).

Adequate reproduction studies have not been performed inanimals to determinewhether this drug aftects fertility in malesor females, has teratogenic potential, or has other adverseeffects on the fetus. l25l_fibrinogen(human)should be used inpregnant womenonly when clearly needed.

It is not knownwhether this drug is excreted in humanmilk. Asa general rule, nursing should not be undertaken while a patient is on a drug since manydrugs are excreted in humanmilk.

Safety andeffectiveness in children havenot beenestablished.

125l@@fibrinogen(human), as well as other radioactive drugs,mustbehandledwithcareandappropriatesafetymeasures

should be usedto minimizeexternal radiationexposureto clinical personnel.Also, care should be taken to minimizeradiationexposure to patients consistent with proper patient management.

Adverse ReactionsSide effects have not been reported following the administration of SENSOR.

Dosage and AdministrationIf material is received thawed, DO NOT USE.

Allow vial and contents to come to room temperature withoutagitation. This process takes approximately 20 minutes.

Thawed material should be a clear, colorless solution; ifmaterial appears clotted or precipitated, DO NOT USE.

RecommendedDose:Approximately 100microcuriesshould beadministeredintravenouslyfor an averageadult (70kg) patient.

The expiration of radionuclide-labeled (1251)fibrinogen is 45days after iodination is completed.

The patient dose should be measured by a suitable radioactivity calibration system immediatelyprior to administration.

Radiopharmaceuticalsshould be used only by physicians whoare qualified by specific training in the safe useand handlingofradionuclides produced by nuclear reactor or particle accelerator and whose experience and training have been approved by the appropriate government agency authorized tolicense the use of radlonuclides.

Interpretation of the ResultsConditions of the legs such as active arthritis, Inflammation,hematoma,phlebitis, surgical or other trauma, may cause incorporation of radlonuclide-labeled fibrinogen and result in apositive test. These conditions do not preclude the use of thefibrinogen test to detect thrombi In areas not affected by suchlocal lesions or trauma,or in the opposite unaffected legand togive additional diagnostic information over the involvedarea.

OtherMethodsUsedInthe Detectionof ThromblIt is generally agreed that, of all the tests for deep-vein thrombosis, venography yields the most definitive results. Accordingly, when confirmation of the diagnosis of thrombosis issought, venography is most commonly used.

It is emphasizedthat venography is reliable in detecting thrombi in the veins of the upper thigh (at the inguinal ligament).Thehigh levels of background radiation emanating from the greatvessels of the thigh and lower abdomen,and from the urinarybladder may obscure SENSORtest results.

HowSupplIedNo. 6104, SENSOR [radionuclide-labeled (1251)fibrinogen(human)]is supplied in a single dosevial. Eachdose (1ml) contains radlonuclide-labeledhumanfibrinogen at a concentrationnot to exceed 2.0 mg of clottable protein.

a HealthCareWorldWide

AbbottLaboratoriesDiagnostics DivisionNorthChicago,IL60064800/323-9100

RADIONUCUDE-LABELED Goes to the trouble spotSENSOR(125@)FIBRINOGEN(HUMAN)todetectDeepVenousThrombosiswhen it starts

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NewDlinensloiis IiiAtlvaiicetlCoinputerAppiiC@1tbuSThe fast and flexible V@ridnV7() seri@ minicomputers @ndsupporting software have. through @)pphi((@tIonin the Varian Cl'scanner and other medical equipment. I)r@ven to he ide@i1for cIini@Iuse. Varian's real-time. multi-task oper1tiII@ sy-@t(?u@VORTEX aridBETA give wide flexibility and ease of u@ for busy. patient-orientedenvironments. Combined with Variari @pe@ial(ij)pll(atiorl software,Varian systems put the most advanced (liqital data proce@iriq to( )kat the medical staff's fingertips.

The first standardized clinical svstenl into )duce(l by Variari wasVARICAM. a comprehensive nu(Iear irR(licine riata processingsystem. now in use in many hospitals ao )tir)d theworld. Gamma canwra raw data an (lircctly -@.-input to VARICAM and submitted t( ) data -@processing procedures according to - .- ‘simple operator instructions. VAHI(AMgives the user unique options furdeveloping his own processingprotocols and manipulating dataoutput format. VARICAMprocessed data are displayedin video black and white,color. or as life-sized hardcopy by the remarkableVarian STATOS electrostatic IJrir@ter plc)tt('r.

Varian computers areused for many other clinicalapplications includingradiotherapy planning. ultrasound image processing.electro-cardioloqv diaqno@is.and intensivc ca r@ni ( HitI ri@ @q

Write Varian Radiatiori -I)ivision. 611 1lansen Wa@.Palo Alto. CA@

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Three scintillation cameras fromOhio-Nuclear are redefining thestandard of excellence in imagequality.A miniature computerlikebrain and precise electronicbalance give diagnostic teamsa unique benefit: Guaranteeduniformity with high resolution.

A Sigma camera from OhioNuclear does what no othergamma camera can do.

Priorto the startofa day'sactivities, a flood is loaded into theDynamic Uniform Flood Correction (DUFC)memory. The Microprocessor Control (MPC) thenanalyzes the flood and determinesthe correction parameters necessary to assure ±5% uniformity.

These correction parametersare then applied to every study

performed, assuring the physicianthat any abnormalities observedare anatomical rather than

machine induced.

Advanced solid-state circuitry.The microprocessor control, afeature of allSigma cameras,incorporates arithmetic, logicandmemory functions in one unit.Image uniformity and resolutionare both optimized—with no

trade-off. Result: Increased diagnostic confidence, faster patientthroughput, and higher camerautilization.

Current owners of OhioNuclear cameras can also realizeSigmabenefits.AllSeries100,110 and 120 models can be refrofitted with MPC.

Sigma means smart.A camera in the Sigma Series isnot only smart elecfronically.It isan intelligentinsfrument for manyother reasons.

Smartfor physicians:Fast analog, nonlinear circuitryprovides consistently superiorimage quality and high count

rate data collection. MPC dataanalysis permits better results fromall peripheral equipment andphoto options.

Smartfor technologists:A Sigma camera is pre-eminentlystable. Because DUFC is continuously monitoring the flood, retuning is minimized.

Auto Peak Track (APT) automaticallycentersthe primaryphotopeak in the desired window.It also makes the use of precalibrated pushbuttons for isotopeselection practical.

The redesigned remote handconfrol contains a completeassortment of confrols. In fact, thetotal Sigma design isfunctionoriented, simplifyingpatient positioning, camera operation andcollimatorchanges.

The confident alternative.Ohio-Nuclear recognizes that youconstantly strive to perfect imagingtechniques.Nowyoucan enhanceyour efforts with the first intelligentcamera system.

A Sigma camera is, simply stated, the only confident alternative.

Considering a gamma camera?Ask us to prove that a Sigmacamera is your best investment.Callor writeus.

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Three Sigma cameras, each with microprocessor control.One will meet your precise Imaging needs.

Sigma 400Standard Field Camera

. Field of View:24.8cm minimum

. Resolution:4.5 mm FWHM (‘9mTc)

. Count Rate:200K cps

SIgma4lO SIgma42OWide Field Camera Mobile Camera. Field of View: •Field of View:

36.8cm minimum 24.8cm minimum. Resolution: •Transport:

5.5 mm FWHM (99mTc) Motor-driven, variable. Count Rate: speed

200K cps •Resolution:4.5 mm FWHM (99mTc)

. CountRate: 200Kcps

. Fast, competent service worldwide. •Full range of collimators available.

Smart ganuna cameras:a tiny electronic brain meansgreater clinical confidence.

For the first time, the following diagnostic management for nuclear cardiology applications.studies can be easily and conveniently per- Also, with system electronics remaining at a centralformed in the crowded Coronary Care Unit, location, only the remote mobile detector is moved.Cardiac Catheterization Laboratory or Stress@ You can quickly and accurately attain RAOLaboratory:@@ and LAO views exhibiting the highest resolution•Left Ventricular Performance (On-Line@@ (2.1 mm) with full 40―arm extension (toward

@@ and away movement) and 2700 head

11 rotation.

@ This is another example of Picker's unique@ human resources benefiting you. Ith a result

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Ejection Fraction)•Myocardial Infarct AssessmentS Shunt Evaluation

. Heart Wall Motion Visualization

•Radionuclide Angiogr a p hic Analysis(First Pass)Now our new generation of modular

DynaCameras makes available a compactcardiac imaging system designed with boththe patient and technologist in mind. It offersthe maximum in patient evaluation and

See our DynaCameras at SNM Island P.

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INC.ACKERMAN,NUCLE@@@

FineTuned Products ...ACKERMAN NUCLEAR INC. is tuned into the refinement and improvement ofCold Kit imaging reagents. Fine tuning these products, however, is not really aseasy as turning a dial or flipping a switch. Years of research and concentratedeffort by skilled professionals have gone into bringing the reliability, quality andservice of our Cold Kit products up to a standard of dependability and efficiencyday after day and batch aftei batch.At A.N.I., Cold Kits are our business . . our only business.

ç@J@@ERMANNUCLEARINC

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Are you tuned in? If so ...and you want to knowmore about our products,call or write:

/ A/(&@

commitment to excellence in service,innovative design, and materialsresearch is more important today thanever before.

Experienced physicists,engineersand design teams are constantlypreparedto serve you.Wecan helptranslate today's ideas into provendetectors for tomorrow's systems.Call us! The Harshaw ChemicalCompany,Crystal & ElectronicProducts, 6801 Cochran Road, Solon,Ohio 44139, (216)248-7400.

A@ INDUSTRY

Whenyourplanscall fora newscintillationdetector design—call Harshaw.

Every Harshaw scintillationdetector representsthe solution to aspecific application problem.Ourinnovative designs have helped toadvance nuclear medical technologyin manyareas,including gammacameras,computerized axial tomographic scanners, and positronemission tomography systems.

Harshaw's partnersh ip with nuclearmedicine spans 25 years. Our

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Anterior PosteriorR.R. L. L.

:@ bone

PROCTER &GAMBLE

Excellent in vitro stabilityGreaterthan98% labelingefficiency8 hoursafterpreparation.Osteoscancontainssodiumascorbate,an antioxidantthat inhibits action ofradiolysisby-productsand oxidantscapableof causingcomplex breakdownand resultantsoft tissuevisualization.

Compatible with all types of technetiumDeliversconsistentlyhigh-qualityscans,usingeither instantor generatortechnetium.

Plus these other Osteoscan benefits. very low tin level to minimize potential for liver visualization and for

interferencewith subsequentbrain scans. rapid blood clearance. high target-to-nontarget ratio. diphosphonate's P-C-P bond for excellent in vivo stability

Forfurther information about Osteoscan, please contact: Arnold Austin,TechnicalManager,ProfessionalServicesDivision,Procter& Gamble(513) 977-8547.

In Europe,contact:Philips-DupharB.V.,CyclotronandIsotopeLaboratories,Petten,Holland.

(5.9MGDISODUME11DRONAT@016MGSTANNOUSCHLOFCE)SKELETALIMAGINGAGENT

Seefollowingpagefor a briefsummaryof packageinsert.

lesiondetection

1:;

Count onPicker@Isotope

Ca@

Brief summary of Package Insert. Before using, please consult the fullPackage Insert included in each kit.

DESCRIPTIONEachvialofOSTEOSCANcontains5.9mgdisodiumetidronateand0.16mgstannouschlorideasactiveIngredients.Uponadditionof ADDITIVEFREE 99mTc@pertechnetate, these ingredients combine with 99mTc toform a stable soluble complex.

INDICATIONSOSTEOSCAN Is a skeletal Imaging agent used to demonstrate areas ofalteredosteogenesis.CONTRAINDICATIONS

None.

WARNINGS

Thisradiopharmaceuticalshouldnotbe administeredto patientswhoare pregnantor lactatingunlessthe informationto be-gainedoutweighsthepotentialhazards.Ideally, examinations using radlopharmaceuticals, especially thoseelective in nature, of a woman of childbearing capability should be performed during the first few (approximately10) days following the onsetof menses.Radiopharmaceuticals should be used only by physicians who arequalifiedbyspecifictrainingin thesafeuseandhandlingof radionuclides produced by nuclear reactor or particle accelerator and whoseexperienceand training have beenapprovedby the appropriategovernmentagency authorizedto licensethe use of radionuclldes.The99mTc@generatorshouldbe testedroutinelyfor molybdenumbreakthrough and aluminum. If either is detected, the eluate should not beused.

PREGAUTIONSBoth prior to and following S9mTc@labeledOSTEOSCAN administration,patients should be encouraged to drink fluids. Patients should void asoftenas possibleafter the 99mTc@IabeIedOSTEOSCAN injectionto minimize background interference from accumulation in the bladder andunnecessaryexposureto radiation.As in the use of any other radioactive material, care should be taken toinsureminimumradiationexposuretothepatient,consistentwithproperpatient management. and to insure minimum radiation exposure tooccupationalworkers.

ADVERSEREACTIONSNone.

DOSAGEANDADMINISTRATIONThe recommendedadult dose of 99mTc-IabeledOSTEOSCANis 1 mlwith a total activity range of 10-15 mCi. 99mTc-labeled OSTEOSCANshould be given intravenouslyby slow injection over a period of 30secondswithineight(8) hoursafterits preparation.Optimumscanningtimeis3-4hourspostinjection.The patient dose should be measured by a suitable radioactivity calibrationsystemimmediatelypriortoadministration.

ACTIONS(CLINICALPHARMACOLOGY)When injected intravenously,99mTc@labeledOSTEOSCAN has a specificaffinity for areas of altered osteogenesis. Areas of bone which areundergoing neoplastic invasion often have an unusually high turnoverrate which may be imaged with 99mTc@labeledOSTEOSCAN.Three hours after intravenousinjection of 1 ml 99mTc@labeledOSTEOSCAN,an estimated40-50% of the injecteddose has beentaken upby the skeleton. At this time approximately 50% has been excreted inthe urine and 6% remains in the blood. A small amount is retained bythe soft tissue. The level of 99mTc@Iabeled OSTEOSCAN excreted in thefeces is below the level detectable by routine laboratorytechniques.

Picker's digital Isotope Calibrator is easyto operate. Select calibration factor, positionsample and push one button. Digital readoutis ready in usually less than one second.Thereare no calculations and no zeroing. The PickerIsotope Calibrator covers all clinically usedisotopes from 2,@tCito 999mCi.

You can be sure of ±5%accuracy, ±3%short-term repeatability and ±1% long-termstability. A molybdenum breakthrough kit helpsassure patient safety. And Picker certifies inwriting that each Isotope Calibrator has beenchecked and calibrated to meet regulatoryagencies' recommendations, and is UL listed.

Like all Picker equipment, the IsotopeCalibratoris backedby Pickerservice. Ithanotherexample of Picker@ynergy—the complete interfacing of systems and services for better diagnoses.

Contact your Picker representative. Orwrite Picker Corp.,Clinical LaboratoryDept., 12Clintonville Road, Northford, CT 06472.

PROCTER&GAMBLE

OSTEOSGAN®@9MCOLSODUMEflORONATE016MGSTANNOUSCHLORIDE)

SKELETALIMAGINGAGENT

L@I@I3I@R®ONEOFTHECIT COMPANIES

II

J&sModel145APortableLocalizationMonitorfor1-125Labeled FibrinogenScanning.Early detection Of ticep veinthrombosis oi the legs can heaccomplished using 1- 125 labelledtiI)riflogefl and the \lodel 145A.Ihe leg is scaflfle(I afterintravenous iiiCCtiOfl of the

labelled fibrinogen. As athrombosis develops, theradio-acti' e fibrinogen isdetected at I)redeternhinedpoints and measured directlyas a percentage of the pre

Cor(Iial cotitit

I Ian(Jil\ cot@pact an(I portable,

s%ilk slan(Iard 1) cell batters operalion@ idi ug at least 100 hours of'

tinc@cleduse, the 145% 1@ocalizationMonitor offers unliniited isotopeselection, stainless steel collimator,and solid state design.

, Features

. Direct Percentage Analog Display

. Compact & Portable (6½ lbsinclu(ling batteries & probe)

. Powere(1 h@ 3 flashlight batteries

(No A.t. 1-lazards)

S i: nlimited Isotope Selection

___ SpecificationsRange: Percent Scale —0-120%

(PS Scale —30, 100, 300,10003000CPS

Meter Response: Fast —2 secondsSlow — 14 seconds

Dimensions:4½―H x 51/2―Wx 8 L (exclusive of handle

Recorder Output 10 myDetector: Nal (TI) crystal, 1―diam.

x 1 mm thick, mounted on PMTwith 7 mg/cm2 aluminum window

And our service, when youneed it, is courteous and quick.

Write or call for completeinformation.

j&sJASINS & SAYLES ASSOC.

908 Concord StreetFramingham, MA 01701

(617) 879-3775

jas MODEL14@ALOCALI1ATIONN

TEST@ lISP@

PEICIPIT

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deteaion@DeepVeinThrombosis

3MAlbuminM

icrospheres(Human)

1.Add4-10ml.of99m1c 2.Shieidcompletelyandvigorouslyshakefor5-15seconds.

STILL!the simplest,quickest-topreparelungimagingagentavailable.

...andhere'swhySimple,two-stepprocedure.Notan ampul,

nota frozenmaterial.Nowaiting,nocomplicatedprocedures or specialized equipment required.Just two easystepsand you're readyto assayand inject.

Uniform particle size, excellent labelingefficiency. Particlesize meetsor exceedsBureauofBiologicsstandards;90%in5-60micronrange.Excellent labeling efficiency when reconstitutedwith a compatible technetium99m.

Won'tagglomerateinthevial, losesvirtuallynolabelingfor8hours(ifstoredbetween2°C.and8°C.).

Idealforthe busylab.Recommendedamountof 99mTcfor reconstitutionhighenoughto allow@iumerousscansfroma singlevial.

SquibbMacrotec®Aggregated Albumin(Human)

MallinckrodtTechneScanhMMAAAggregated Albumin(Human)

I .Removereactionvialfromfteezerandwaitapproximately5mi,,utesforcontentstocometoroomtemperature.

2. Add99mTc@Maintainshieldingatalltimes.

Medi+PhysicsLungaggregateTMReagentAggregated Albumin(Human)

1.Shakeampu/vigorouslytosuspendparticles.

2.Openampul.

Emphasis added by Squibb to point out certain differences in procedures.

3. Gentlyagitatevialforfew4.N/owtostant/1o15seconds. minutesatroomtemperature.5.Visually

inspectvialfor 6.Agfratetoeffectpresenceoflargeaggregates.homogenoussuspensionofffpresent,donotuse. theaggregatedalbumin.•@Recommend@J

maximumactivity:60mCi.3.

Removevialfromshield(withforceps)andplaceincenterofoperatingu/ftasonicbathcontaining3/4―ofwater.Bathshouldbeprotectedbyleadglassorbricks.Ultrasoundfor5m,nutes.Recommended

maximumactivity:30mCi.3.

Wlthdraw(veryslowly) 4.lnject(veryslowly)syringe1.5-2.0ml.ofaggregate contentsintomiringv,Wfromampulv.ithsyrmge.5.Wrap

mixingvialinabsorbent6. Add0.5-2.0ml.of 99mTc@ 7.Shake contentsvigomusly@@roi@ccandplaceinlead insalineintoshieldedmixing justbeforeremovingaliquot

shield. vial.Shakevigorouslyforat intendedforpatientuse.least30seconds.Incubateatroomtemperaturefor2-5mitiutes.‘Recommended

maximumactivity25mCi/mi.•B@cj

on manufacturers' product information. NOTE: S@emanufacturers' package Inserts betor@th@preparatlon of any of these products.

duced by nuclear reactor or particle accelerator and whose experience and training have been approved by the appropriate government agency authorized tolicense the use of radionuclides.

Note: Macrotec (Aggregated Albumin [Human]) is not radioactive However.after @Tcis added, adequate shielding of the resultant preparation should bemaintained.

PRECAUTIONS:Intheuseofanyradioactivematerial,careshouldbetakentoinsure minimum radiation exposure to the patient consistent with proper patientmanagement, and to insure minimum radiation exposure to occupational workers

Aseptic technique is essential in the preparation of Technetated (Tc-99m)Aggregated Albumin (Human).ADVERSE REACTIONS: At present, adverse reactions have not been reportedfollowingtheadministrationofthisproduct.

For full prescribing information, consult package insert.HOW SUPPLIED: Inboxesof5 vials.

Unlike many companies involved in nuclear medicine, Squibb is also a broadline pharmaceutical house .. .and has been for over a century. Sowhen it comes toformulation and quality control procedures, we wrote the book. Consider thatbeforeyoupurchaseanyradiopharmaceuticalAtSquibbqualityisawayof life.

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SQUiBB HOSP1TAL@E.R.Squibb&Sons,Inc.Princeton,N.J.08540

01976E,R Sgu,bb&Sons inc H6O6@5O4

Recommendedmaximumactivity:50mCi.

(Aggregated Albumin[Human])Macrotec (Aggregated Albumin [Humani) is a sterile, non-pyrogenic, lyophilizedpreparation of aggregated albumin. Each vial ofthe preparation contains 0.08mg.tin as chloride, 1.5 mg. denatured human serum albumin, and 10 mg. NormalSerum Albumin (Human).

INDICATIONS: For use in perfusion lung imaging as an adjunctto other diagnostic procedures.CONTRAINDICATIONS: At present there are no known contraindications to theuse ofthis product.WARNINGS: Radiopharmaceuticals should not be administered to patients whoare pregnant, or during lactation, unless the benefits to be gained outweigh thepotential hazards.

Ideally, examinations using radiopharmaceuticals, especially thoseelective in nature, of a woman of childbearing capability, should

be performed during the first few (approximately 10) daysfollowing the onset of menses.

Since @‘Tcis excreted in milk during lactation, formulafeedings should be substituted for breast-feedings.

Radiopharmaceuticals should be used only by physicians who are qualified by specific training in the

safe use and handling of radionuclides pro

ClinicalData SystemIV—Simultaneousacquisitionand processingfrom twocamerasHigh-Speed, High Capacitydisc driveRemoteTerminalfor displayand processingColor Display—64 colorssimultaneouslyZoom —increases image size without lossof digital resolution

MUGA —Up to 32 segmentsof the cardiaccycleRefocusing —Increasesgamma camera systemperformance approximately 3O%

Edge Detection —Enhances locating morphological boundariesPreset User Protocols

10340BUBB ROADCUPERTINO, CALIFORNIA 95014

TELEPHONE(408)255-6353

Eliminatutheneedforfloodphantomsanddiscsourcs

QUALITY ASSURANCE SOURCE POS1TIONER*WITH LEAD COLLAR

AND SMITH ORTHOGONALHOLE PHANTOM*Measuressensitivity•field size •intrinsicresolution•“X―and “Y―axis linearity •non-uniformityof response•uniformityofspatial resolution•monitorsperformanceof accessorydisplayandstorage-devices•estimatesthe lineardimensionsof theorgans imaged •evaluates the performanceof total bodyscan accessory

I.Image of OrthogonalHolePhantom from storage

Sscope during study.

A SINGLE IMAGE PLUS TOTAL COUNTS OBTAINEDPROVIDE A COMPLETEQUAUTY ASSURANCESTUDY

NewOrthogonalHolePhantomeliminatesthe need to rotate phantoms throughnumerous orientations to yield desiredinformation.Used in conjunctionwith thefixed-geometry source holder and positioner, data is obtained in one singleoperation: Phantom is placed on top ofuncollimatedcamera. Lead collar is positionedover phantom.A calibratedsyringecontaining99mTcis inserted into the fullyshieldedsource holder (with centeredonfice fixed at 54―abovecamera),and camera is activated.The resultingscintiphoto

. providestotal-parameterinformation.Takes less than 5-minutesas a daily QAroutine.

Complete InformatIon available upon request

ATOMICDEVELOPMENTCORP..£@ 7 FAIRCHILDCOURT,PLAINVIEW,N.Y. 11803

(516)433-8010

.

SIMPLEOPERATION•EASYTOUSE•REPRODUCIBLE•ECONOMICAL

*pateflt Pending

Visitus at the SNMShow—IslandI, June20-23, ChIcago,Illinois

Now...Acompleteaxed-geometrysystemprovides―oneimage―qualityassurancetoranscintillationcameras

Nowandinthefuture...relyonGEforyournuclearimagingneeds.

Compatiblebuildingblocks...permityour MaxiCameraTMsystemtogrow with your needs. You can select equipmentto matchyour

requirements now—thenadd system components such as a GE filmFormatter as your department expands. Be confident these components

will be compatiblewith your basic system.

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It all starts with MaxiCamera ...The 400 mm field of view simplifies imaging for large organstudies. The detector is positioned with ease and precisionbecause of MaxiCamera's gimbal and counterbalance.

You can add a GE Formatter to record up to 42 static ordynamic images on 8 x 10 film and incorporatethe cameraelectronics in the same console. Select data handling systemsto fit your needs—from basic acquisition and playback toadvanced systems for cardiac and renal studies.

Expand your technic capabilities with an optionalSelectascanTM whole body scanner that moves the detectorover or under the patient. For easy patient transfer andpositioning, includethe Universal Imaging Table. And savevaluable floor space while simplifying collimator changingwith the new Collimator Stacker.

Whether your needs are basic. complex or changing . . . theMaxiCamera system can satisfy those needs now and in thefuture. For details, contact your GE representative.

General Electric Medical Systems,Milwaukee, Toronto, Madrid.

GE: leading the way in nuclear imaging.

GENERAL@@@ELECTRIC.7@

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star reusable antibody chamber, ispre-calibrated . . . and the same antibody is used over and over. It's “curtains―for RIA procedures that selfdestruct.And, ARIA II performs the “toughacts―like Estriol, cortisol, Progesterone, Testosterone and T4.And,for an encore, the system can evenhandle12513Hand57Co.Flexibility. Simplicity. Economy.

Good Show!

BectonDickihson

175W.2950S.,SaltLakeCity,U.84115801-487-8773

There's a new automated AlA showin town. It's called ARIA II.Review its characters on the TVscreen,inrealtime...followedbyaduplicate printout of the results.The entire production takes about 3minutes per specimen . . . after only a2 minute review of the script on TV.The various scenes —pipetting,incubation, counting, calculations —areallautomatic...directedbyamini-computer. The operator isexcused from watching the performance.The show stopper is the ARIA UI“non-destructive―approach. The

SNM Chicago June 21-24AACC Chicago July 17-22

PRESENTING ARIA IIautomated RIAwith a whole new cast of characters

sneakpreviews

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The CLEON Irnager. . it's about time.

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Norwood M@Ss:@chLIsf'tts ::@@@ :@sp-r-:cc

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Rectilinearscannerorscanninggammacamera?

Combinetheadvantagesofbothwitha

UNIONCARBIDE

3M Brand I

of

. Uniform particle size (1O-35@@)means consistent images from day to day and patient to patientwith 3M Brand INSTANT MICROSPHERES.Stable sphericalparticles minimize disintegration or aggregation.

(approximately 900,000)allows you to minimize the number injected and still attainaccurate images.

Technetium 99muptake is normally higher than 99% throughoutthe day for superior perfusion informationwithout interference from background activity.

Our new brochure offersyou acomparative look at lung imaging agents—sideby side. Plus moreinformation on 3M Brand INSTANT MICROSPHERES.Writefor it today. .@

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@BRlEF SUMMARY OF PRODUCT INFORMATIONALBUMIN MICROSPHERES (HUMAN) (10-35 . DRIED)INSTANT MICROSPHERES FOR LABELING WITHTECHNETIUM 99m.

Scintillation imaging of the lungs with.@@ TclabeledAlbuminMicrospheresis Indicdtedas,inadjunct to other diagnostic procedures whenever informition about pulmonary circulation is desired.@ The mostuseful clinical applications of lung imaging ire in thediagnosis of 1) pulmonary embolism, 2) chronic obstructivepulmonary diseases such as emphysema ind chronicbronchitis, 3) pathological conditions which impedepulmonary abscess, and 4) other pulmonary diseases suchas pneumonia and tuberculosis.The safety of Albumin Microspheres in patients withknown right-to-left cardiac shunt has not been est@ibIisIiedand its use in such patients is contraindicdted.

The possibility that hypersensitivity re@ictionsmay occur should be considered whenever protein-containingmaterials such as 3M Brand Instant Albumin Microspheresare administered. Administration of epinephrine, antihistamines and corticosteroid drugs should he consideredwhenever a hypersensivity reaction occurs. Since@ â€Tc isexcreted in milk during lactation, formula@feedings shriufti

For rilore information. write or call toll free 1-800-@ 11)71

be ,uhstitutecl for brca',t-feer1inq'@. Ridioph.irni;iceutic.il'@should be used only by physici.tn'@ who are qualified byspecific training in the sife use md handling (If r.idionuclides produced by nuclear redctor or p,rtl(_le acceleratorand whose experience md Ironing hive been PPrOVe(I bythe ,ippropriate government agency tuthor,ied to licen'-ethe use of radionuc I ides. A' in the u',e ofany other radioactive material, care should he t.@ken toinsure minimum r,idc@tion expo'ure to the pitient,consi',tent with proper I)atent mdndgement. nd to inuremininium radiation exposure to o(.cupati(iniI worker'@.

The met frequently reportedadverse reaction' ,i'-'-oci(ite(I with the use of Albumin

M icro@,pIieres are trin@ient fici.il flu'.hing md dy'pnei.Less frequent adverse reactions ire trinsa@nt nauca,perspir@ition and cyanosis. An ,i(Iverse reaction, @ihicIi occur'rarely, is severe respiratory di'tre'. The literiturecontains OflC report of ;in alleged inaphy!ictoid re(.tion toAlbumin Microsphere.Administration of ephine- —phrine .intihi',t,imine'

*and corticosteroid drugs —‘liould he coniderid -whenever (1 hyper'en'-itivity re@iction occur.

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D@AGNOS1HC PFVDUCTS

P@dicthbIe @rticIe

mEdical Products DivisionSERVING HEALTH CARE WTH PEOPLE PRODUCTS AND IDEAS

Amershammadethe first RIAkit.Sincethenwe'vedevelopedacomprehensivelineof kitsandreagents.There'sat leastoneforevery laboratory. Looking forRIAkits and reagents?Look toAmersham,thelineof experience.

Phone312/593-6300or800/323-0668(Tollfree).InCanada,416/842-2720or800/261-5061(Toll free).

ACTH RIAKITANTI-DNA KITCORTIPAC (Cortisol) KITCYANOCOBALAMIN REAGENTDIGOXIN RIA KITESTRIOLRIAKITFOLATE KITFSH RIAKITHPL RIA KITINSULIN RIA KITLIOTHYRONINEREAGENTT-3RIAKITT-4 RIA(PEG)KITTHYOPAC-3 (T-3 Uptake) KITTHYOPAC-5 (T-4 and NTR) KITTHYROXINE REAGENT

I AMERSHAMCORPORATIONA SUBSiDIARY OF THI RADIOCHEMICA& CENTIt

FOREXAMPLE:Twostudles@bothperformedon a Baird-AtomIcSystem Seventy-Seven.Left, the patienthasa provenInferior.walImyocardlal infarct. This TI.201 scan mdicates an area of decreasedmyocardialperfusion. Scanning time, 12-15 mm.;isotope cost, $80.88. Right, a regionalejectIon fraction Image from the Tc-99Mfirst pass study also showsa decrease inmyocardial performance in the area of theinfarct. imaging time, 30-50 sec.; isotopecost, 35g. Myocardial perfusion and myocardial performance. System Seventy-Sevenperforms both studies with excellence.Static cardiac imaging or dynamic cardiacquantitation —either capability or both —fromBaird-Atomic.

For more information on System Seventy-Seven and Baird-Atomic,call us, toll-free, at 800-225-1487, extension 6500. Today.

Intornitlonil S&es and Service:BAIRD-ATOMIC(Europe)By. Veenkade26-27-28a,TheHague,Hoiiand.Teiephone:(070)603807.Teiex:32324.cable: BA1RDCOHAGUEBAIRDATOMIC,UMITED,EastStreet,Braintree,Essex,England.Telephone:Braintree628. Telex:987885.Cable:BAIRTOMICBAIRD-ATOMIC,md.ECorn.,Ltda.,Pauiasta,2O73@14cu1412,01311SaoPaulo,SP,Brazil.Telephone:(011)289-1948.Telex:01122401. Cable BAIRDATOMICSPAULO

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BDAIRO-AIDMlj@JHomeOffIce: Baird-Atomic,Inc.125 Middlesex Turnpike, Bedford, Mass. 01730Tel.(617)276-6000—Telex:923491—cable: BAIRDCOBFRD

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1'•

It's a tongue twister but its meaning is simple.Picker's Programma ble Automatic Calculator(PAC) has much more laboratory use than justcomputing our PACE Gamma Counter output.

PAC is really two instruments in one: a computerprogrammed to automatically analyze not onlyradioassay data but also creatinine clearance,acid base balance, quality control, inventorycontrol or many other lab tests. And, it's acalculator capable of performing over 30built-in math functions.

A unique feature of PAC is the hard copyprintout with the name of the assay, standard curve parameters including curve QC,and most important, the patient values withconfidence limits. It offers quick visualreference to curve fit and in one loading ofthe sample changer, multiple tests can berun, freeing the operator for other jobs and

cutting his time by 30%.Pickers PAC is programmed to think of calcula

tions as you do and requires no special programmingskills. The result is a full alphanumeric readout.

This is another example of Picker's uniquehuman resources benefiting you. It's a resultof our expertise in the diagnostic modalitiesof clinical laboratory, nuclear, x-ray, ultra

sound, computed tomography, therapy, filmsystems and supplies. Only Picker has allthese resources.

The PACE-PAC Radioassay program,PALL, gives fast, automatic and accuratecurves for RIA and CPB assays. For ad

ditional information, contact us for aninteresting article by simply writing Picker

Corporation, 12 Clintonville Road,Northford, CT 06472, Attention: Marketing

Manager, Clinical Instrumentation.

UL listed

times.

PACc.

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DiscoverthehumanresourcesinPicker'synergy

PICKER®ONEOFTHECIT COMPANIES

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itinwrThe CRC-20 dose calibrator incorporates a micro-processorwhich stores time and activity information for up to 19 formulations of 8 radionuclides.

Thedecay-adjustedvolumeiscalculatedanddisplayedautomat!-cally.

Three-copy Radionuclide DoseComputation/MeasurementRecord. One for the patient'schart,the second for Atomic EnergyCommission accountability, thethirdfor billing.

All thisto reduceexposure. . . in morewaysthanone. Like all CapintecCalibrators,the CRC-20features:0 Geometryindependence0 Largest sample size (up to 200cc vial)0 90+ isotopecalibrations ‘@ I0 Moly-assay capability Plea5@send information on the CRC-200 Sensitivity (0.1 uCi resolution) ,0 Exclusive 10 atm argon ionization chamber I Name _________________Title_________0 Replaceable inserts I Hospital

Department@ - cARlNTEC1NC :;ate/ziP____________I 136SummitAvenueI Montvale,NewJersey07645U.S.A. Phone________________________________(_@ (201) 391 -3930 Telex: 138630 (CAPINTEC MTLE)

The CRC-20is usedonlyoncetosetconcentration;it is nevernecessary to handle the multidosevial for repeat measurement.

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ACTUAL SIZE

akethebestavailable

“Workon the ultimate, but in themeantime,makethe bestavailablebetter.―

Our people have always accepted thechallenge and it's what makes us theleader.

We agree that all things consideredthe Landauer Gardray 8 film badgesystem is the best available personneldosimeter. And, although we are always looking for the ultimate, we havecontinued to work hard and investmoney and time to make it better.

Greatly simplified ordering procedures —permanently encoded uniquenumbering offilm, which is independent offilm darkening —new improvedtechniques for analyzing the film foranomalies that may affect the “meaning―of the exposure and new N.R.C.annual statistical summary reportsavailable now, are just some of theways our people are working hard tomake it better for you.

Write or call for more details.

@ R.S.LANDAUERJR.&CO.A@COMPANYGlenwood Science ParkGlenwood, Illinois 60425 . (312) 755-7000

‘erfusion+Ventilation:Thetwotogetherarediagnosticallybetter. . . @.The ventilation-perfusion ratio (@ ) isthe crucial factor determining the re@gionaloxygen partial pressure. This can beevaluated by assessing the gas exchangeoccurring in any part of the lung. Thesingle most sensitive non-invasive test fordiagnosing Pulmonary Embolus is theperfusion lung image.l However, pulmonary diseases, such as chronic obstructivelung disease, infectious diseases andneoplasms are all characterized by alteredarterial blood flow. Therefore the mostreliable way to increase the specificity ofperfusion lung imaging is to add a Xenon133 ventilation study.2

Urokinasc Pulmonary Embolism Trial. A National Cooperative Study.Clrculatl(,n (Suppl II) 47:11-Al. 197,3 (April)

7Wagncr, Henry N. Jr.,Strauss, H. William. Radioactive Traccr@lii TheI)iftere,it,aI 1)ia,giusi.s ef !Silniiniarv L:nhnll%nl l'rogress flCardiovascular 1)iseases,Vol. XVII, No. 4 (January/February), 975.

PULMOLITETM—TechnetlumTc 99mAggregatedAlbuminKitDiagnostic—ForIntravenousUseIndicatlonsand Ueage TechnetiumTc99m aggregatedai,I@uminisindicated asalung imaging agentto be used asan adjunct in the evaluation of pulmonary perfusion.Contralndicatlons:TechnetiumTc99maggregatedalbuminshouldnotbeadministeredto patientswithseverepulmonaryhypertension.TheuseofTc99m aggregatedalbumin iscontraindicated in personswith a historyofhypersensitivity reactionsto productscontaininghumanserum albumin.Wamings The possibilityofallergic reactionsshould beconsidered inpatientswho receivemultiple doses.Theoretically,theintravenousadministrationofparticulatematerialsuchasaggregatedalbumin imposesatemporary smallmechanicalimpedimentto bloodflow.Whilethiseffectis probablyphysiologicallyinsignificantin mostpatientstheadministration ofaggregated albuminispossiblyhazardousinacutecor pulmonaleandotherstatesofseverely impaired pulmonary blood flow.This radiopharmaceuticalpreparationshouldnot beadministeredtochildrenor to pregnantor lactatingwomen unlesstheexpectedbenefitsto be gained outweighthe potential risks.Ideally, examinations using radiopharmaceuticals, especially thoseelectivein nature,ofawoman ofchildbearing capabilityshould beperformedduringthefirstfew(approximately10)daysfollowingtheonsetof menses.Precautions:Incasesofright-to-leftcardiacshunt,additionalriskmayexistduetothe rapidentryofaggregated albumin intothe systemiccirculation.Thecontentsofthe kit are not radioactive.However,afterthesodiumpertechnetateTc99m isadded,adequateshieldingofthefinal preparation must be maintained.Thelabeling reactionsinvolvedin preparingtheagentdepend on maintaming tin in the reduced state. Anyoxidant present in the sodium pertechnetateTc99msupply maythusadverselyaffectthe quaiityofthe preparedagent.Hence,sodiumpertechnetateTc99mcontainingoxidants,orotheradditives, should notbeemployed withoutfirst demonstratingthatit iswithout adverseeffecton the propertiesofthe resultingagent.Thecontentsofthevial aresterileand non-pyrogenic.It isessentialthatthe userfollowthedirectionscarefully and adhereto strictasepticproceduresduring preparationofthe radiodiagnostic.TechnetiumTc99m aggregated albumin is physically unstable and assuchthe particleswillsettlewith time. Failureto mix the vial contentsadequatelybeforeusemayresult in non-uniformdistributionofradioactivity.It isalso recommendedthat,becauseofthe increasingprobabilityofagglomeration with aging, a batch ofTechnetium Tc99m aggregatedalbumin not beusedaftereight hoursfrom the time of reconstitution.Refrigerateat2°to8°Cafter reconstitution.lfblood iswithdrawn intothesyringe, unnecessarydelaypriorto injectionmayresuftinclot formation in situ.Thecontentsofthe vialare undera nitrogenatmosphereandshouldbeprotectedfrom air. Donotuse ifclumping orfoaming ofthecontents isobserved.Adequatereproductionstudieshavenotbeenperformed in animalstodeterminewhetherthis drug affectsfertility in malesorfemales, hasteratogenicpotential,orhasotheradverseeffectsonthefetus.TechnetiumTc99m aggregated albumin should be used in pregnantwomenonly whenclearly needed.It is not known whetherthisdrug is excreted in human milk. Asageneral rule,nursingshould not beundertakenwhilea patientison adrugsince manydrugs are excreted in human milk.Safetyand effectivenessin children havenot beenestablished.Asintheuseofanyradioactivematerial,careshouldbetakentominimizeradiationexposureto the patient,consistentwith proper management,andto insureminimum radiationexposureto theoccupational worker.Radiopharmaceuticalsshouldbeusedonly by physicianswhoarequalifiedbytraining andexperiencein thesafe useand handlingofradionuclidesandwhoseexperienceand training havebeenapprovedbytheappropriategovernmentalagencyauthorizedtolicensetheuseof radionuclides.Adverse ROaCIIOnSTheliteraturecontains reportsofdeaths occurringafterthe administrationofaggregated albuminto patientswith pre-existing severepulmonary hypertension.Instancesof hemodynamicor idiosyncratic reactions to preparations ofTc 99m-labeled aggregatedalbumin have been reported.Hypersensitivityreactionsare possiblewheneverprotein-containingmatenaissuchasTc99m-labeled aggregatedalbuminareusedinman.Epinephrine,antihistaminesandcorticosteroidagentsshouldbeavailablefor use.DoeageandAdministration Therecommendedintravenousdoserangefortheaveragepatient(7Okg)is1to4 millicuries.Thevolumeofthedosemayvaryfrom0.2to 1.3ml.Therecommendednumberofaggregated albumin particlesto beadministeredperdose is200,000-700,000withthesuggested numberbeingapproximately350,000.Foreaseandaccuracyindispensingthe preparedagent,it is recom.mended that priorto reconstitution, concentrated sodium pertechne

tateTc99m befurtherdiluted to avolumeof8mlwithfresh, preservafive-freesodium chloride injection (U.S.P.).HowSupplied:PULMOLITE'MTechnetiumTc99mAggregatedAlbumin Kit issupplied in kitsoffive(5)orthirty(30)vials, sterile andnon-pyrogenic,eachvial containing in lyophilizedform:

Aggregated albumin (human) - 1.0mgNormal human serum albumin - 10mgSodium chloride - 10mgStannouschloride dihydrate, maximum - 0.07mg

Eachvial contains3.6-6.5x 10 aggregatedalbumin particles.PULMOLITEcontainsnopreservative;afterreconstitutiontheshieldedvial should be stored at 2°to 8°C.Includedineachfive(5)vial kitisone(1) packageinsertand six(6)radiationlabels.Includedineachthirty(30)vial kitis one(1) packageinsertand thirty-six (36) radiation labels.Cat.No.NRP-415

XenonXe 133 Gas(CALIDOSETM)DispensingSystem.Indications:InhalationofXenonXe133gashasprovedvaluablefortheevaluation of pulmonary function and for imaging the lungs. It may alsobe applied to assessmentof cerebral flow.Contralndlcations To date, no knowncontraindicationsto the useofXenonXe 133gas havebeen reported.WamlngsThisradiopharmaceuticalshouldnotbeadministeredtopregnantor lactatingwomen unlessthe benefitsto be gained outweighthe potential hazards.Ideally, examinations using radiopharmaceuticals, especially thoseelectivein nature,of a woman of childbearing capabilityshould be performed during thefirstfew (approximately 10) days following the onsetof the menses.Radiopharmaceuticalsshould be usedonly by physicianswho arequalified by specific training in the safe use and handling of radionuclidesproducedbynuclearreactoror particleaccelerator,andwhoseexperienceand training havebeenapproved by the appropriategovernmentalagencyauthorizedto licensethe useof radionuclides.Precautions:Asintheuseofanyotherradioactivematerialcareshouldbe taken to insure minimum radiationexposure to the patient,consistentwithproperpatientmanagement,andto insureminimumradiationexposureto occupationalworkers. ExpiredXenonXe 133gas shouldbe controlled in a mannerthat is in compliance with the appropriategovernmentalagencyregulations.XenonXe 133 adheresto some plastics and rubber and should not be allowedto stand in tubing or respirator containers.Such unrecognizedlossof radioactivityfrom the dosefor administration may render the study non-diagnostic.XenonXe 133gas deliverysystems,i.e.,respiratorsor spirometers,and associatedtubing assemblies must be leakproofto avoid loss of radioactivity intothe laboratory environs not specifically protected by exhaust systems.Adverse ReaCtiOnS To date, no adverse reactions based on the use ofXenonXe 133gas havebeen reported.Dosageand Administration: XenonXe 133gas is administered byinhalation from closed respirator systems or spirometers. Thesuggestedactivity rangeemployed for inhalationby the averageadultpatient (70 kg) is:

Pulmonaryfunction including imaging:in3 litersofair.

Cerebral blood flow: 10-30mCi in 3 liters of air.The patient dose should be measured by a suitable radioactivitycalibration systemimmediatelypriorto administration.HowSupplied: The XenonXe133gas is supplied as part of theCalidose'TMsystem,consistingof 2 ml unit dose vialsand the Calidosedispenser* for shieldeddispensing.Normally vials containing either 10 or 20 mCi/vial, packed up to 5 vialsper shield tube, are supplied.Vial setscontaining up to 100mCi/vialare available.*Patent Pending

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CEA-ROCHE,when used as a biologicalmarkerfor followingthe cancer patient's response totherapy, should be employed periodically todetermine a trend. The first test (preferablytaken prior to beginning treatment) is used asa baseline against which subsequent tests aremeasured. Investigators have recommendedthat assays be run every 3-4 weeks duringperiods of active therapy, then once every1-2monthsforthefirst sixmonthsaftercompletion of therapy; and finally,every 6-12months as part of the long-termfollow-up.

Results of periodic CEA-ROCHEassayshave been found to closely mirror clinicalresponse to therapy. Effective therapy normallyresults in a drop in an elevated CEA titer tolevels below 2.5 ng/ml. Conversely, CEA titersusually remain elevated in the presence ofrefractory disease or when therapy is unsuccessful.

In cancermanagementperiodic CEA-ROCHE assaysmaydetect recurrenceof diseasemonths beforeotherclinicalsignsareevident

2.5

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•DØI_@>•i_@>•r_@>r_@i_@N__Monthsl 2 3 4 5 6 7 8 9 10 11

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Four years of extensive clinical use have shown CEA-ROCHEto be an important part of the total management programfor patients with internal carcinoma: breast, lung, GIand GU tracts. Used periodically, this assay is avaluable means of...

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Progression/RecurrenceCurveThe importanceofperiodicCEA-ROCHEassays for the prompt recognitionof tumorprogression/recurrence has been found to be“crucialin the clinical follow-up of these[cancer]patients.―Thesamereportalsoshowedthat progressivelyrisingtiter levelsoftenpreceded actual clinical relapse by weeks tomonths.*

Name

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Address

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The XENON-133 INHALATION METHOD for measurement of regional cerebral blood flow(rCBF)offersthe advantageof a quick,simple,atraumaticand safe procedureswhichelirnmates the carotid artery puncture of the Xenon injection method. The inhalation methodallows simultaneous bilateral measurements, thus enabling an unaffected hemisphere toserve as reference to an affected one. The atraumatic nature of this j@vestigation makesit possible to perform frequent measurements over prolonged periods on a broad pa

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This is a complete system, including the Xenonadministration system, a digital data collectionsystem with 8, 16, 24 or 32 brain detectors, anair curve scintillation detector with associatedelectronics and a computer interface withpunched paper tape or casette tape output. Themodular design allows easy system expansionin the field. Off-line calculation and presentation of rCBF-valUes can be performed on anycomputer able to process the Fortram programsdeveloped by OBRIST et at (1975) and RISBERG et al (1975). The digital output of theMEDITRONIC INHALATION CEREBROGRAPH can also be interfaced to other peripheral devices or on-line connected to a computer.Exclusive distributor in the U.S.A. and Canada:Victoreen Instrument Division, Sheller-GlobeCorporation, 10101 Woodland Avenue, Cleveland, Ohio 44104.

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Volume II: Printed Scintimages,presentsmedical-quality, blackand white photographic reproductions of eachScintimage. Thisvolume is appropriately keyed to Volume I by case numberfor easeof use when referring to each case study. A comprehensive index of particular diseaseprocessesis presented forthe busy practitioner.

Never before have 500 actual clinical casesbeen published inone source, specifically designedas a referencefor the nuclearmedicine professional, at such a low cost. For less than 60tper case study, this set provides day-to-day assistanceat yourfingertips in the preparation, administration, and interpretationof results of the rapidly developing diagnostic technique ofscintillation imaging.

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. For clinical practitioners, teachers,. and researchersThe CRC Atlas of Scintimaging has been designed to fill the daily needs of the practitioner of clinical nuclear medicine.In a convenient loose-leaf format, this coordinated, two volume set presents500 documented clinical casesand their attendant Scintimages (scintillation images). Featuring a broad spectrum of scintimaging techniques for common and rare diseaseprocesses,the Atlas offers a unique basis for comparative study and is a valuable aid in diagnosis. It is also a constructivetool for review and study purposesfor residency training, and specialty board examinations.

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CardiacGate

Cardiac Gate is designed to synchronize thecardiac image exposure with predeterminedphases of the cardiac cycle.

The Cardiac Gate has two modes ofoperation: manual and automatic. In the manualmode, delay and exposure time parameters areset manually, using the R wave of theelectrocardiogram as a reference. In the@iutomaticmode, microprocessor circuitryautomatically tracks the cardiac cycle andcomputes the position of end-systole andend-diastole. In the automatic mode,end-systole and end-diastole exposures aremade without any calibration settings.

The dual gating operation mode allowsrecording of both end-systole and end-diastolesimultaneously in a srlit screen two imageformat.

The cardiac cycle can even be divided intonine equal time segments and the imagecorresponding to each displayed simultaneouslyin a nine image format.

The Cardiac Gate includes a completeelectrocardiograph module. The built in heatedstylus strip chart recorder records both the ECGtrace and the gating intervals.

The Cardiac Gate provides both ECG andgating outputs for computer interface.

1RuckmanRd.Closter, N.J. 07624(201) 767-1750

OptiImager

Opti-Imager is designed to provide anorgan image with effects due to respiratorymotion minimized. Opti-Imager has twodistinct modes of operation: continuous motioncorrection and respiratory gating. In thecontinuous motion correction mode, the motionof the organ is tracked and correctedelectronically without the need to attach anysensors to the patient. The distribution ofcounts within the organ image is monitored andcorrections are applied to continuously shift theimage before it is displayed to compensate fororgan motion. Correction is made for motion inboth the X and Y direction. Thus, the gammacamera is not gated and all the counts providedby the detector are recorded. The time requiredto attain a statistically satisfactory image is thesame for both a motion corrected and anuncorrected image. In the gating mode,inspiration plateau and expiration plateauimages are recorded. The dual gating operationmode allows recording of both inspiration andexpiration plateau images simultaneously in asplit screen two frame format. Dual scalersrecord the number of counts in each image.

The Cardiac Gate and Opti-Imager can besynchronized to yield a combination of bothcardiac and respiratory gating. Mail coupon toreceive detailed information and sample clinicalstudies.

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It takes 8 times longer to make a collimator that has 6-sided holes.Is that sucha good idea? If you're looking for a practical, efficientcollimator designed specifically for low energy work . . . it's a verygood idea. All NISE camera collimators have hexagonal holes foruniform resolution and maximum efficiency.

Another NISE idea is the insert type collimator that eliminates theneed for space wasting carts. And these space savingcollimators havethe specifications to do the job right. With NISE ideas like theseyou can be happy as a bee.ForScanners:Special L.E. High Efficiency Collimators for use with all 3―or5―detectors and 123 Iodine.FWHM: 1/4―for 123 Iodine and 3/16―for 99-mTcAvailable for Abbott, EC-Scint, G.E., Picker, Ohio-Nuclear and Searle Rectilinear scanners.

SELD

A TRADITIONOF HIGH QUALITYIN NUCLEAR IMAGING

1964 - SELO realize first commercially successful dualhead scanner.

1969 - SELO realize the OS 7 digital scanner, still unsurpassed in performance and reliability.

1976 - SELO realize the KR 7 supercamera, the highestresolution large field camera with a triple windowanalyser.

1977 - SELO enter the field of nuclear tomography withthe realizationof an emissioncomputerizedaxialtomographicsystem,which allows multiplesection imaging on the whole body.

Axial emission tomography is differentiated fromX-ray tomography in that information on@ functional morphology )> becomes available, thusproviding complementary information, which isextremely useful for differential diagnosis.

and largefield/highresolution detecting head In conjunction with a powerful and highlyflexiblecomputerenablesall tradltional and newly developed@ In vivo@ studies(scintlgraphy and fast dynamic studies) to beperformed with the same system.

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it'sourbusinessto helpyoumakeit..Our business . . . our only business . . . at DiagnosticIsotopes, is the production of radiopharmaceuticals.From packaging to in vivo performance, our productsreflect our concern with the needs of the nuclearmedicine professional.Constant research and development, consistentattention to quality control and convenient packagingcontribute to a product you can use with confidence .confidence that the manufacturers of that productare as concerned with excellence as you are.Diagnostic Isotopes manufactures products for use inbrain, kidney, lung and pancreas imaging, skeletalimaging to delineate areas of altered osteogenesis,cerebralbloodflow,musclebloodflow,pulmonaryfunctionstudies,estimateglomerularfiltrationrate,assess renal perfusion and for the diagnosis ofcardiac abnormalities.Whenyourpatientlookstoyoufortherightdiagnosis.depend on Diagnostic Isotopes to help you make it.

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Everybody benefits from comprehensive technologicaladvances like the widely usedOmnimedical AVM-3 Automated Ventilation ModuleWiththe AVM-3 radioxenon ventilation studies are automated,simplified, reproducible oneman operations. Patient cooperation is not needed. Interfacedwith the gamma camera, theoperator selects a study sequence—Single Breath (tidalvolume or vital capacity) orRebreathe, singlyor in combination—and pushes the start

button.Scintiphotosareinitiatedautomatically at precise predetermined intervals.The datais then collected. The entire

system is enclosed in a streamlined case mounted on anoverbedtableforuseon patientsin either sitting or supine positions.TheAVM-3 is easyto position, easy to use, easy on thepatient, even easy to store. Andit's easy to buy. $3,750. FOB. LosAngeles. Omnimedical guarantees 30day delivery. Now,you can breathe easier, too!AVM-3 by Omnimedical, P.O.Box 1277,Paramount, Ca. 90723(213) 633-6660.

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andSouthAmericanTours@Tour A FROMLOSANGELESI$1435.40

DEPARTURE OCTOBER, 17 RETURN NOVEMBER 5

LIMA CUZCO MACHU PICCHU —RIO DE JANEIRO —IGUASSU FALLS —BUENOS AIRESDELUXE HOTELS —TRANSFERS —SIGHTSEEING —AIR FARE INCLUDED

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DESIGNED FOR PHYSICIANSWHOONLY WISH TO ATTEND THE CONGRESS

Tour C FROMNEWYORK1$769.00DEPARTING OCTOBER 21,1977 RETURNING OCTOBER 29,1977

FOR BROCHURE CONTAINING ADDITIONAL INFORMATION

.... U.. ••@••U ••..u...... a. •uu ... S.. ••@••••••U@

AEROLINEAS ARGENTINAS545 South Olive Street Phone (213) 688-1070

Los Angeles, CA 90013 Southern California

Pleasesendinformation aboutyour SouthAmericaToursin connectionwith

XIV INTERNATIONAL CONGRESSOF RADIOLOGY

Address

City State Zip.

Office Phone___________________________ Home Phone________________________

By retrofitting your presentCapintec Calibrator with a CRC-UComputer/Printer Upgrade, we'llteach it to remember activity in-@formation for up to 19 formulations of 8 radionuclides.

We'll teach it to calculate and display automatically the decay adJusted volume needed for eachdose.

We'll even teach it to print neatlya three-copy Radionuclide DoseComputation/Measurement Record; one for the patient's chart,the second for NRC accountability,thethirdforbilling.

While your present calibrator isaway getting smart, we'll loan youa replacement.

Please send more information on the CRC-U

..Title

Department —

Address

City/State/Zip

PhoneJNM

We'Hteachyourad cafibratorsomenewthcks.

Name

Hospital

U CAPINTECINC136SummitAvenueMontvale,NewJersey07645U.S.A.

(201) 391-3930 Telex: 138630 (CAPINTEC MTLE)

c;@

I%3'@―

1Kit

(

@ .

II

For brain imaging, kidney imaging,assessing kidney perfusion, and for estimating

glomerular filtration rate.

Ordering and Pricing Information(800) 227-0595 (Outside California)(415) 837-1 321 (Inside California)

GRPGeneralRadioisotopeProducts3120 Crow Canyon Road San Ramon, California 94583

Introducing

Kidney/BrainScanningKitPenetetatecalciumtrisodium@1@/tlnKit (1)USAN designation for CaNa3DTPA[calciumtrisodlumdiethylenetrlaminepentaacetatej

For use in preparation of TechnetiumTc-99m penetetate/tin when reconstitutedwith Technetium Tc-99m in 0.9% sodiumchloride solution.

p I ScannIfl@J Kit

DsscrlptlonEach vsalof the kit contains a lyophilized mixture of 5 mg of sterile, p)rogen-f roePentetate Caictum Trisodium and 0.25 mg Stannous Chforlde. Sodfum hydroxide and/orhydrochloric acid may have been used to adjust thepH.When

sterile. pyrogen-free Sodium Pertechnetate Ic 99m a added to the vial, a chelate,Technetium Tc 99m Pentetate is formed. The precise structure of the chelate is unknownat this time. Administration is by intravenous injection for diagnosticuse.Physical

Character/st/ca

Technetium Tc 99m decays by isomer/c transition with a physical half-life of 6.03 hours.Photons that are useful fordetect/on and imaging studies are listed in Table1Table

I. Prlnclpel Radiation Emlulon DataMean

S Mean EnergyRadiationDIsIntegrationGamma-2

87.9 140.5

ExternalRadiationThespecific gamma ray constant for Tc 99m is 0.8 R/mCi-hr at 1 cm. The first half value

layer is 0.2 mm of Pb. To facilitate control of the radiation exposure from millicurieamounts of this radionuclide, the use of a 2.7 mm thickness of Pb will attenuate theradiation emitted by a factorof 1,000.Table II. Radiation Attenuation by LeadShisldingShield

Thickness Coefficient oflPb)mmAttenuation0.2

0.50.95 10'1.8 1022.7 iO@3.6 i0@@4.5 10'

PrecautionsTechnetIum

Tc99mPentetateaswell asotherradioactivedrugsmustbehandledwithcare and appropriate safety measures should be used to minimize external radIationexposureto ctinical personnel.Also, careshouldbetakento minimizeradiationexposureto patientsconsistentwith properpatientmanagement.To

minimize radiation dose to the bladder, the patient should be encouraged to voidwhentheexaminationis completedandasoften thereafteraspossiblefor the next4-6hours.Technetium

Tc 99m Pentetate should be formulated within one (1) hour prior to clinicaluse.Adequate

reproductive studies have not been performed in animals to determine whetherthis drug affects fertility in males or females, has teratogenic potential, or has otheradverse effects on the fetus. Technetium Ic 99m Pentetate should be used in pregnantwomen only when clearlyneeded.It

is not known whether this drug is excreted in human milk As a general rule nursingshould not be undertaken while a patient is on the drug since many drugs are excreted inhumanmilk.Safety

and effectiveness in children have not beenestablishedAdverse

ReactIonsNo

adverse reactions specifically attributable to the use of Technetium Tc 99m Pentetatehave beenreported.Dosage

and AdministratIonThe suggested dose range for IV. administration to be employed in the average patient(70 kg) is:

Kidney imaging and glomerular filtration rate estimation 3 to 5 mCi.Brain Imaging or renal perfusion : 10 to 20 mCi.

The patient dose should be measured by a suitable radioactivity calibration systemimmedla(,ly prior to administration.

Radj@l@maceuticalsshouldbeusedonly by physicianswhoarequalified by trainingandiexperiencedinthesafeuseandhandlingof radionuctidesandwhoseexperienceand training have been approved by the appropriate government agency authorized tolicensethe useof radionuclides.The components of the Technetium Tc 99m Pentetate Kit (Chelate) are supplied sterileand non-pyrogenic. Aseptic procedures normally employed in making additions andwithdrawalsfrom sterile, non-pyrogeniccontainersshouldbeusedduringadditionofpertechnetatesolution andthe withdrawalof dosesfor patientadministration.Technetium Tc 99m Pentetate is prepared by simply adding 1 to 10 ml of SodiumPertechnetate Tc 99m solution to the vial and swirling for about one minute. Shieldingshould be utilized when preparing the Tc 99mPentetate.Radiation

DosimetryThe estimated absorbed radiation doses' to an average patient (70 kg) from anintravenousinjection of a maximumdoseof 20millicuries of Tc99mPentetateareshown in TableIV.Table

IV. RadiationDosesTissue

Absorbed RadIation Dose (rada/20 mCI)Dillman. L.T. . and Von der Lage, F.C. Radionuclide Decay Schemes and NuclearParameters for Use in Radiation-Dose Estimation, MIRD pamphlet No. 10, p.62,1975.To

correct for physical decay of this radionuclide, the fractions that remain at selectedintervalsafterthetimeofcalibrationareshowninTableIll.Table

Ill. PhysIcal Decay Chart : Ic 99m, half.llfe 6.03hoursFraction

FractionHours Remaining HoursRemaining—5

1.777 5 0.563—4 1584 6 0.502—3 1.412 7 0447—2 1259 8 0.399—1 1.122 9 0.3550@ 1 000 10 0.3171 0.891 11 0.2822 0795 12 0.2523 0.708 18 0.1264 0631 24 0.063

January1977

Technetium Tc 99m DTPA Kit[Chelate]Diagnostic

Kidneys 1 8WholeBody 0.12BladderWall 2-hr. void 2 3

4.8-hr.void 5 4Testes 2-hr.void 015

4.8-hr. void 0 21Ovaries 2-hr.void 0 22

4.8-hr.void 031

I Method of Calculation : A Schema for Absorbed-Dose Calculations for Biologically

Distributed Radionuclides, Supplement No. 1, MIRD Pamphlet No. 1. p. 7, 1968.

HowSupplIedA. 6 sterile immediate drug containers each containing : (Lyophilized)

—5.0mg CaNa3DTPA—0.25mg stannous chloride—ExcessCaCl2and NaCI—NaOHand/orHCI toadjust pH—Nitrogen gas

B. 6 radioactivitystring labelsfor the immediatedrugcontainerC. 6 radioactivity labelsfor the leadshield.

@ package Insert.E. ‘!@(lnstructloncard.

PreparationDo NOTUSEIF THEREISA VACUUMIN THEIMMEDIATEDRUGCONTAINERORIFAIR IS INJECTED INTO THE CONTAINER WHEN THE DOSE IS WITHDRAWN.FORMULATEWITHINONEHOURPRIORTOCLINICALUSE.1. Fix the string radioactivity label to the neck of the immediate drug container.2 Remove the flip-cap from the container and place the container in the lead shield.3. Useagermicideto swabthe septumof the sterile reactioncontainer.4. Aseptically inject into the immediate drug container 1 to 10 ml of sterile non-pyrogenic

0.9% Sodium Chloride solution containing radioactive Sodium Pertechnetate Tc-99mand withdraw an equal volume of nitrogen gas. Do not allow air to enter container Donot use Technetium Tc-99m solution if it contains foreign matter.

5. Dissolve and mix welt by gently shaking the container in the shield for 30 seconds toone minute.

6. Measure and record the Tc-99m radioactivity and calibration data on the string

radioactivity label and on the large radioactivity label. Enter the time of expirationin the space provided and fix the label to the shield.

7 Maintain adequate shielding at all times.

This reagent kit is approved by the California Department of Health for distribution topersons licensed pursuant to Sections 35.14 and 35 100. Group Ill of 10 CFR 35. orunder equivalent licenses of Agreement States

GRP General Radioisotope Products3l2OCrow Canyon Road San Ramon, California 94583Telephone (800) 227-0595 (Outside California)

(415) 837-1 321 (Inside California)

A subsidiary of (,@) Blo-Dynamlcs. Inc.

Calibrat,on Time

ClinicalPharmacologyFollowing its intravenous administration Technetium Ic 99m Pentetate rapidlydistributes itself throughout the extracellulsr fluid space from where It is (promptly)clearedfrom the bodyby glomerularfiltration. Thereshouldbe little or no binding of thechelate by the renal parenchyma. A varIable percentage of the Technetium Tc 99mPentetatebinds to serumproteins; this rangesfrom 3.7% followIng thesingle injectionto approximately 10% if the material is continuously infused. Although the chelate givesuseful informtion on the glomerular filtration rate, the variable percent which is proteinbound leads to a measured glomerular filtration rate which is lower than the g(omerulsrfiltration rate as determined by inutin clearances.

TechnetiumTc9gmPentetatetendsto accumulatein intracraniallesionswith excessiveneovsscularity or an altered blood-brain barrier. The chetsle does not accumulate in thechoroid plexus.

Since Technetium Tc 99m Pentetate is excreted by glomerular filtration, the images ofthe kidneys obtained in the first few minutes after injection represent the v:scular poolwithin the kidney. Subsequent images of the kidneys represent radioactivity which is inthe urine of both the collecting system and the renal pelvis.

Indications and Usage

Technetium Tc 99m Pentetate may be used to perform kidney imaging. brain imaging. toassessrenalperfusion,andto estimateglomerutarfiltration rate.

ContralndlcationaNoneknown.

Wamlnga

Technetium Tc 99m Pentetate should not be administered to children or to patients whoare pregoant. or to nursing mothers, unless the benefits to be gained outweigh thepotentialhazards.

Ideally, examinations using radiopharmaceuticals, especially those elective in nature ofa woman of child-bearing capability should be performed during the first few(approximately 10) days following the onset of menses.

G@P Qsnsral R.dlo$sotops Products

A subsidiary of 4) Sb-DynamIcs, Inc

. Full floating top for infinite positioning.48―travel in “X―direction (24―fromeithersideof center)10―travel in “Y―direction

30―to 39―continuous height adjustmentin “Z―direction

. Finger-tip directional control.

. Unobstructed frame accommodates ALLcameras and ALL scanners.

C Solid, sturdy welded construction.. 5―diameter swivel casters with floor locks

for maximum mobility and positive positioning.. Lucite top . . . Polyurethane mattress included.

Until September1, 1977, ADC will creditthe FULL PURCHASEPRICEof yourModelXYZ-101, XY-101, SC-i 01 orEZ -101 ImagingTable towardthepurchaseof a new ModelXYZ-202.All youdo is purchasethe XYZ-202at $1595.00.When your XYZ-202arrives,put the oldtable in the crateandship it backto us.Wewill deduct the FULL ORIGINALPURCHASE PRICE of your old table fromthe price of the XYZ-202.

Takeadvantageof this unusualbudget-saving opportunity to “update―your AD'@‘magingTable.Orderyour newXYZ202 TODAY!

Dlmnslons:32―widex75―longx 30―high.Capacfty: 350 lbs.ShIppIng Weight: 300 lbs.

Stop by Island I at the 24th Annual Meetingof the SNM, June 2G23, Chicago, illinois and see our XYZ-202

ATOMICDEVELOPMENTCORP..A@ 7 FAIRCHILDCOURT, PLAINVIEW, N.Y. 11803

(516)433-8010

You bought the best ADC tableNow g2 one better

GetFULLCREDITforyour“old―tablewhenyoupurchasethenewXYZ-202ImagingTable

I SPECIFICATIONS

XYZ-202IMAGINGTABLE

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@@— @@@jxl

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Your order Isprocessedon the same day as received.

Ask about quantity discounts

available on allour kits.

Remember!Oursisafreeze-driedDTPAthatdoesnotrequirerefrigerationandisreadyforadditionofTc99m solution.Madewithmonocalciumtrisodiumsalt,ratherthanpentasodlumsalt.

Available in a six pack, each ofthe six vials contains a sterile, pyrogen-free mixture of20.6mgofCaNa3diethylenetriaminepentaacetate,0.210mgofstannouschlorideandHCland/orNaOH to adjustpH.

VISIT US AT BOOTH 706

SNM ANNUAL MEETING IN CHICAGO

CISR&Jiophormaceuricals1lnc.5 DeAngelo Drive/Bedford, Ma. 01730/Telephone: (617) 275-7120;

outside Massachusetts (800) 225-1145/TELEX 94-9465

Th@EA@AR

RADIOPHARMACEUTICALS

%Ps@4putPotassiumPerchlomte

so your pharmacydoesn't@Savetimeandpharmacy—orderpaperwork.Keepa 100-capsulebottleof Perchloracaponhand at all times. This pre-packaged,inexpensive, convenient dosage form ofpotassium perchlorate is designed to Jimprove diagnostic certainty when /pertechnetate is used as a brain imaging //agent. To place an order, simply contact f@your Mallinckrodt representative or call@ AMallinckrodt toll free, 800-325-3688.(Missouri customers call collect314-895-0880.)

Mallinckrodt, Inc.P.O.Box 5840St.Louis,Mo.63134

Just oi*rMallinckrodt

(Potassium Perc

MALLINCKRODT, INC.St.Louis.Missouri63134

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w@putFbtassiumF@tth1orate ___in capsules sosour pharmacydoesr@tha'@to.

Catalog Number O25@100/200-mg Capsules/Bottle

INDICATIONSPotassiumperchlorateshouldbe administeredtominimizethe accumulation of pertechnetate Tc-99m in the choroidplexus and in the salivary and thyroid glands in those patients receiving sodium pertechnetate Tc-99m injection forbrain and blood pool imaging and placenta localization.CONTRAINDICATIONSNone.

WARNINGSPotassium perchlorate has been administered chronicallyin doses of 200-1000 mg per day for the treatment of hyperthyroidism. Fever, rash, lymphadenopathy, renal damage,agranulocytosis, and fatal aplastic anemia have all beenreported as complications of this therapy. Because severalalternative therapies for hyperthyroidism are available,PorchloracapCapsulesare not recommended for treatmentof this condition. These adverse effects are dose relatedand have not been observed in patients receiving singledoses of potassium perchlorate under the conditions described under Dosage and Administration.Use in Pregnancy: The safety of this drug in pregnantwomen is not known and the agent should not be administered during pregnancy or lactation unless the informationto be gained outweighs the predicted hazard.Do not administer Perchloracap Capsules that have beensubjected to excessive heat and/or moisture as manifestedby deformation and/or discoloration of the capsule.To prevent loss of the desiccated atmosphere always replace the bottle cap immediately after use.ADVERSE REACTIONSGastricirritationhasbeenreportedin therapeuticdosesofperchlorate greater than one gram per day. The possibilityof temporary local gastric irritation exists with the administration of subtherapeutic doses in capsule form.DOSAGE AND ADMINISTRATIONTheusualadultdoseis200to 400milligramsof potassiumperchlorate administered orally one-half to one hour beforeinjection of sodium pertechnetate Tc-99m. The maximumdoseshouldnotexceedonegram.PerchloracapCapsulesshould be administered with several ounces of water to prevent gastric irritation.

See package insert for prescribing information.

\@EAR

RADIOPHARMACEUTICALS

POSITIONSWANTEDNUCLEAR MEDICINE TECHNOLO

gist (full time) for a ninety nine bedhospital. Must be registered. Excellentbenefits and working conditions. All facilities completely new. Contact the Administrator, Bryan W. Whitfield MemorialHospital, Box 890, Demopolis, Alabama36732.

HOSPITAL CONSULTANTS — NUclear medicine specialists. Trainee position. A consultant trainee position ispresently available with our expandingprofessional service firm. Applicants musthave a B.S. or advanced degree in thebiological and/or physical sciences with asolid background In the operations ofnuclear medicine facilities. The trainingorientation program and starting salarywill be commensurate with capabilities.Basic duties will include serving hospitaland physician clients throughout the Midwest to maintain regulatory and licensecompliance, radiation safety, record systems, quality assurance programs, instrument calibrations and leak tests. Our consuiting services also cover continuing education, over-all planning, organization, andmanagement categories. Requests for further information ( include curriculum vitaeand reference list) should be sent to Box606, Society of Nuclear Medicine, 475 ParkAvenue South,New York.N.Y. 10016.

A.R.R.T. REGISTERED CHIEF TECHnologist wishes to relocate in northcentralnorthwest state. Five years in-vivo experience. Skilled in personnel management anddevelopment of new departments. Pastpresident of technologist section chapter.References available on request. Reply to:Box 604. Society of Nuclear Medicine, 475Park Ave South N.Y. N.Y 10016.

NUCLEAR MEDICINE TECHNOLOgist, registered, with experience. immediateavailability. Please reply to P.O. Box 605,Society of Nuclear Medicine, 475 ParkAvenue South, New York, N.Y. 10016 orphone (804) 288-4425.

FIFTY THREE YEAR OLD WIDOWERwith Boards both in Internal Medicineand Nuclear Medicine desires a full orpart time job in the ares of Nuclear Mcdicine. Because of living in a relativelysmall town, we have done very little inthe terms of in vitro studies with the cxceotion of thyroid tests. I am interestedonly in the West Coast which includesHawaii. Please renly to I West Alder,Room 218, Walla Walla, WA 99362.

CHIEF NUCLEAR MEDICINE TECHnologist, ARRT registered. Eight years cxperience. Capabilities Include In vivo andin vitro applications. Expert with mostequipment and procedures. Interested Inplanning, organizing and managing established or new facilities. Prefer to relocatenorth west or north east U.S. Reply toBox 601 , Society of Nuclear Medicine, 475Park Ave. South, New York, N.Y. 10016.

NUCLEAR MEDICINE PHYSICIAN.Completing a 2 year residency program ina University. Seeking position for July1977. Holds California License by FLEX.Box 602, Society of Nuclear Medicine, 475Park Ave. South, N.Y., N.Y. 10016.

PHYSICIAN CERTIFIED ABNM, UNIversity trained, 5 year experience in clinical nuclear medicine (imaging and invitro) . teaching and administration. Dcsires relocation, private practice or fulltime. Please reply: P.O. Box 603, Societyof Nuclear Medicine, 475 Park AvenueSouth, New York, N.Y. 10016.

pital, Halifax, Nova Scotia. The positionhas considerable administrative responsibility. The hospital has 825 beds and is themajor adult teaching hospital of DalhousieUniversity. The successful applicant willhold a joint appointment with the Facultyof Medicine, Dalhousie University and theVictoria General Hospital Department ofRadiology. Certification (or eligibility forcertification) by the Royal College of Physicians and Surgeons of Canada in NuclearMedicine and/or Diagnostic Radiology isrequired. Contact : Dr. J. R. Standen, Head,

____________________________________Departmentof DiagnosticRadiology,Victoria General Hospital, Tower Road, Hali.NUCLEAR MEDICINE RESIDENCY, fax, Nova Scotia, B3H 2Y9, Telephone

Medical College of Wisconsin. Two year (902 ) 428-2452.integratedprogramincluding710bedVA _____________________________________General Hospital, 600 bed County MedicalComplex and two large community hospi- BECAUSE OF A RECENT EXPANtals. Several cameras each interfaced to sion to a fully integrated program, thecomputer. Ultrasound training included. Divisions of Nuclear Medicine at the GeorgePositions available in July 1977. Nondis- Washington University Medical Center nowcrimination in employment. Contact Robert has positions available (PG4 and PG5).C. Meade, M.D., Chief, Nuclear Medicine This program includes the George WashService, VA Center, Milwaukee, WI 53193. ington University, Washington Hospital414-384-2000, EXT 2138. Center and VA Hospitals. Training cx_____________________________________posureto a varietyof imagingdevices,

computer applications, in-vitro and clinicalpatient services are provided. Opportunityfor research in an active research programin Radiochemistry/Radiopharmaceutical Dcvelopment and Medical Imaging associatedwith an advanced degree program (MS/Ph.D. ) is encouraged. For applicationsplease contact: Richard C. Reba, M.D.,Director, Nuclear Medicine Training Pro

___________________________________ gram, GWUMC, 901 Twenty-Third Street,N.W., Washington, D.C., 20037. Phone202-676-3458.

POSITIONSOPENNUCLEAR MEDICINE TECHNOLO

gist. 500-bed medical center is presentlyseeking a registered or registry eligible nuclear medicine technologist to work in arapidly expanding nuclear medicine laborstory. Competitive salary and excellent hoepital benefits. Reply may be directed to : JoeWells, Employment Manager, Mt. CannelMedical Center, 125 South Souder, Columbus, Ohio 43222 (614) 225-5288. An EqualOpportunity Employer—Male/Female.

REGISTERED NUCLEAR MEDICINEtechnologist needed for 200-bed acute general hospital. Competitive salary, excellentfringe benefits. Personal interview required.Send resume to : Dr. Allen D. Flynn, Dept.of Radiology, Billings Deaconess Hospital,P.O. Box 2547, Billings, Montana 59103.Phone (406) 259-5551.

NUCLEAR MEDICINE TECHNOLOgist (part time and full time) for 600 bedteaching hospital providing excellent cxperience and opportunity for continuedlearning. Excellent fringe benefits. Registered in nuclear medicine or graduate ofA.M.A. approved nuclear medicine program. Equal opportunity employer. Sendresume to: Mr. Lawrence Flood. PersonnelDepartment, U of I Med. Center, P.O. Box6998, Chicago, flhlnois 60680 Tel (312)996-6688.

NUCLEAR MEDICINE TECHNOLOgist. Immediate opening for a technicianin a fully accredited 370-bed communityand university affiliated hospital. situatedin scenic northcentral Pennsylvania. Proficiency required in radioimmunoassaywork, imaging dynamic studies and cornputer applications. Department is equippedwith cameras, rectilinear scanners, automated well counters and a computer. Goodsalary and full benefits. Contact Jack D.Cain, Director of Personnel, The Williamsport Hospital, 777 Rural Avenue, Williamsport,PA 17701.

NUCLEAR MEDICINE RESIDENCY.University of Missouri-Columbia and HarryS. Truman Memorial Veterans Hospital.Two year combined nuclear medicine program beginning 1 July, 1977 with openings for two qualified candidates. Broadbasic science and clinical exposure including all in-vitro studies, Ultra-Sound andComputed Tomography. Active staff withopportunity for independent and collaborative research. For further informationcontact : Richard A. Holmes, M.D., Chief,Nuclear Medicine, University of MissouriMedical Center, N206, Medical Sciences,Columbia, Missouri 65201—314-882-2541.

NUCLEAR PHYSICIAN : Applicationsare invited for a senior position in Nuclear Medicine in the Department of Diagnostic Radiology, Victoria General Hoe

RADIOLOGIST WITH NUCLEAR MEDicine interests needed for locum tenens.May lead to perm. assoc. Opportunity forfamily vacation in So. Calif. Please replyP.O. Box 600, Society of Nuclear Melicine.475 Park Avenue South, New York. N.Y.10016. Please state available dates.

NUCLEAR MEDICINE TECHNICIAN.$10,370 per annum. Career Civil Service.500-bed general medical and surgical hospital and 750-bed domiciliary. Affiliatedwith Eastern Virginia Medical School. Loeated in a highly desirable area withabundant educational and recreational facilities. Two years of nuclear medicinetechnician experience required. Write : Personnel Service (05B), VA Center Hampton, Va. 23667. Equal Opportunity Employer.

CHIEF NUCLEAR MEDICINE TECHnologist needed : Excellent equipment andworking conditions. Supervisory responsibilities in academic clinical programs.Must be experienced technologist. Fullrange of technical skills required. Call orwrite, Eileen Kjerulf (206) 543-3538, Nuclear Medicine, RC-70, University Hospital,Seattle, Washington 98195.

NUCLEAR MEDICINE TECHNOLOgist (part time and full time) for 600 bedteaching hospital providing excellent cxperience and opportunity for continuedlearning. Excellent fringe benefits. Registered in nuclear medicine or graduate ofA.M.A. approved nuclear medicine program. Equal opportunity employer. Sendresume to : Mr. Lawrence Flood, PersonnelDepartment, U of I Med. Center, P.O. Box6998, Chicago, Illinois 60680. Tel. (312)996-6688.

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Howard University College of Allied Health Sciences, has animmediate opening @oran educator in Nuclear Medicine Technology. This position offers an excellent opportunity to developan innovative program utilizing a multidisciplinary approachwith other ionizing radiation programs. A Masters' Degree inEducationor in a related scienceis preferredalong with registry in Nuclear MedicineTechnology.A minimumof five yearsclinical experiences required. Excellent teaching facilities in amodern,well equipped clinical department.Excellentpotentialfor programaffiliation with area hospitals.Salary to $20,000based on experience and qualifications. Curriculum Vitae ónd informational requests submitted ta:

Ms. Mattie J. Tabron,M.Ed., R.T.,Chairperson,DepartmentofRadiation Therapy Technology, College of Allied Health Sciences,Howard University, 4th and Bryant Streets, Northwest, Washing.ton, D.C. 20059. Howard University is an equal opportunity/affirmative action employer.

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Ithasbeenrepo@edthatfapos@veorfa@e-negativebran soansmayresultwhenbranscansuswtgsodiumpertechnetateTc99mareperformedaftera bonescanhas beendone us@gan agentcontaning stannousions,e.g.,a p@irophosphateboneagent.Thisisthoughtto bedueto the interactionof Tc 99m wth stannousions ins@ered bloodcats. Therefore,in thosecaseswherebothbrasiandbonescansareindicated,thebran scanshouldbe performedfirst,if feasitAe.@AJternative@,',anotherbrainimagingagent,suchasTc99mDTPP@maybeerr@oyed.

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The Minneapolis Veterans Administration Hospital seekscandidates for the position of AssistantChief, Nuclear Medicine Service effective July 1,1977.

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- permits ANY radionuclide

to be measured.

NUCLEAR ASSOCIATES, INC.Subsidiaryof

RADIATION-MEDICAL PRODUCTS CORP.

ONLY

@1495

Forfulldetailswrite for Bulletin I 70-A

100 VOICE ROAD •CARLE PLACE, N.Y. 11514 •(516) 741-6360

MILLICUR IFS

ASSOCIATES INC.

r@L

1972rE 100

COMPETITIONWINNER

For information write or call:KEVEXCORPORATIONKEVEXINTERNATIONALCORPORATIONMedical SystemsDivision898MahlerRoad,Burlingame,CA94010,U.S.A. Tel: (415)697-6901TWX910-371-7249

NEW non-invasivediagnostic methodsFeaturing Kevex X-ray fluorescence systems

I.InVitro:The Kevex-Ray®StableTracerAnalyzer.X-ray fluorescence analysis in-vitro affords tracer studies innew and conventional areas without the use of radioactivetracers,i.e.,replacingthemwithstabletracers.. established applications in:

KINETICS OF X-RAY CONTRAST AGENTSGLOMERULARFILTRATIONRATE (GFR)RED CELL VOLUMES (RCV)EXTRACELLULARFLUID VOLUMEPLASMA VOLUME (ECFV)

. high specificity and sensitivity, wide (10@) dynamic range

(fromppmto%). no radiation exposure to patient or personnel, with increased0 capabilitiesforserialstudiesandstudiesofnormals. no storage, handling, or disposal of short half-life

radioactivematerials. simple, accurate, cost effective

. several different system formulations to suit your

needand budget

II.InVivo:TheKevex-Scanifi BX-rayFluorescence

,@\ . Thyroid Analyzer.@ It . Highresolution thyroid imagingwithoutradioactive tracer

I@ \... •Quantitativetotal iodineinformationwith calibration@@ @:i.@ •Very low local radiation dose-zero whole body dose

V:@ •Complementary and unique information of thyroid disease‘ state via the endogenous iodine distribution

•Adaptable to most conventional rectilinear scanner systems(Picker, Ohio Nuclear, Nuclear Chicago, Baird-Atomic, etc.)

•Adaptable for dedicated operation, or in parallel with Na(l)uptakedetector

NUCLEAR4-IMAGE FORMAT

DELTA 6-IMAGE

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ITONLYMAKESSENSE!Nearly 400 institutions have discoveredthe sensibility of the simplicity, reliabilityand economy of NISE@FORMAT.TM(Pronounce Nice Format.) Although othersystem manufacturers make bold claims(and ask bold prices !), when the comparisonis made it only makes senseto goNISE-FO RMAT. TM

Thefreeandsometimescarelessuseofadjectives in advertising seemsto undermindthe practical points of some products.We hope you understand when we say thatNISE-FORMAT TM j@terribly good and quiteunique, and it gets the job done withoutsuch circumstance as loss of valuablefloorspace and the need for an expert forinstallation and calibration. You don'teven need film holders for viewing andfiling.

And most important is the affordable price.Now,mostanydepartmentcanalsohaveoursystem as a back-up unit to the so-called‘sophisticated'systems. Nearly 400 institutionshave understood our adjectives. We will be

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léchneScariPYF Kk_(&ann@ Pympho@)

@ Acons@tent@skd@a1

Anterior wall infarction, anterior view

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Left anterior oblique

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For further information contact yourMallinckrodt representative, or, to ordercalltollfree800-325-3688.

Mallinckrodt, Inc.675 Brown RoadHazelwood, MO 63042

RADIOPHARMACEUTICALS I Left lateral

For brief summary of prescribing information, please see next page.

Now a@oavailable forroudne use as anadjunctinthe

TechneScan®PYP@Kit(Stannous Pyrophosphate)

Kitfor the Preparationof TechnetiumTc99m StannousPyrophosphateDiagnostic--ForIntravenousUse

CLINICALPHARMACOLOGYWhen injected intravenously, TechneScan PYP Tc 99mhas a specific affinity for areas of altered osteogenesis. It is also concentrated in the injured myocardium, primarily in areas of irreversibly damagedmyocardial cells.Oneto two hoursafter intravenousinjection of TechneScan PYP Tc 99m, an estimated 40 to 50 percent of theinjected dose has been taken up by the skeleton, andapproximately 0.01 to 0.02 percent per gram of acutelyinfarcted myocardium. Within a period of one hour, 10to 11 percent remainsin the vascularsystem,decliningto approximately 2 to 3 percent twenty-four hours postinjection. The average urinary excretion was observedto be about 40 percent of the administered dose after24 hours.

INDICATIONSAND USAGETechneScan PYP Tc 99m is a skeletal imaging agentused to demonstrate areas of altered osteogenesis, anda cardiac imaging agent used as an adjunct in thediagnosis of acute myocardial infarction.As an adjunct in the diagnosis of confirmed myocardialinfarction (ECG and serum enzymes positive), the mcidence of false negative images has been found to be6 percent.Falsenegativeimagescanalsooccur if madetoo early in the evolutionary phaseof the infarct or toolate in the resolution phase. In a limited study involving22 patients in whom the ECG was positive and serumenzymes questionable or negative, but in whom thefinal diagnosis of acute myocardial infarction was made,the incidence of false negative images was 23 percent.The incidence of false positive images has been foundto be 7 to 9 percent. False positive images have alsobeen reported following coronary by-pass graft surgery,in unstable angina pectoris, old myocardial infarcts andincardiaccontusions.

CONTRAINDICATIONSNone.

WARNINGSThis radiopharmaceutical should not be administered topatientswho are pregnantor lactating unlessthe information to be gained outweighs the potential hazards.Ideally, examinations using radiopharmaceuticals,especially those elective in nature, of a woman of childbearing capability should be performed during the firstfew (approximately 10) days following the onsetof menses.Warning: Preliminary reports indicate impairment ofbrain scans using Tc 99m pertechnetate which have beenpreceded by bone scan. The impairment may result infalse positives or false negatives. It is recommended,where feasible, that brain scans precede bone imagingprocedures.Radiopharmaceuticalsshould be used only by physicianswho are qualified by specific training in the safe use andhandling of radionuclides produced by nuclear reactoror particle accelerator and whose experience and training have been approved by the appropriate governmentagency authorized to license the use of radionuclides.The Techne5can PYP Kit must be maintained atrefrigerator temperature until use.The contents of the TechneScan PYP reaction vial areintendedonlyforuse inthe preparationofTechnetiumTc 99m Stannous Pyrophosphate and are not to bedirectly administered to the patient.Sodium pertechnetate Tc-99m solutions containing anoxidizing agent are not suitable for use with theTechneScan PYP Kit.

The contents of the kit are not radioactive. However,after the sodium pertechnetate Tc-99m is added,adequate shielding of the final preparation must bemaintained.Techne5can PYP Tc 99m should not be used more thansix hours after preparation.

PRECAUTIONSAs in the use of any other radioactive material, careshould be taken to insure minimum radiation exposureto the patient, consistent with proper patient management, and to insure minimum radiation exposure tooccupationalworkers.Bone ImagingBoth prior to and following Techne5can PYP Tc 99madministration,patientsshould be encouragedto drinkfluids. Patients should void as often as possible after theTechneScanPYPTc 99m injection to minimize background interference from accumulation in the bladderand unnecessary exposure to radiation.CardiacImagingPatient's cardiac condition should be stable beforebeginningthe cardiacimagingprocedure.If not contraindicated by the cardiac status, patientsshould be encouraged to injest fluids and to void frequently in order to reduce unnecessary radiationexposure.Interference from chest wall lesions such as breasttumors and healing rib fractures can be minimized byemploying the three recommendedprojections.ADVERSE. REACTIONSNone.

DOSAGE AND ADMINISTRATIONThe recommended adult dose of TechneScan PYP is:

1. Skeletal Imaging —5 to 15 millicuries (1 to 14milligrams stannous pyrophosphate).

2. Cardiac Imaging—b to 15 millicuries (4 to 7milligrams of stannous pyrophosphate).

TechneScanPYPTc99m is injected intravenouslyovera 10- to 20-second period. For optimal results, boneimaging should bedone 1to 6 hoursfollowing administration. Cardiac imaging should be done 60 to 90 minutesfollowing administration. The acute myocardial infarctcanbevisualizedfrom 24 hoursto 9 daysfollowingonset of symptoms, with maximum localization at 48to 72 hours. Cardiac imaging should be done with agamma scintillation camera. It is recommendedthatimages be made of the anterior, left anterior obliqueand left lateral projections.The patient dose should be measured by a suitableradioactivity calibration system immediately prior toadministration.HOW SUPPLIEDCatalogNumber—094 TechneScanPYPKitKit Contains:

5—StannousPyrophosphate Reaction Vials (Lyophilized) for the preparation of Technetium Tc 99mStannous P@irophosphate.ReactionVial Contains:15.4 mg Sterile Stannous Pyrophosphate (Lyophilized). Hydrochloric acid is added for pH adjustment prior to lyophilization.

5—Pressure-sensitive Caution—RadioactiveMaterial―labels.

5—Radioassay Information String Tags.

@mImTR!ITiT;E@@0 Mallinckrodt. Inc.

çNUCLE@) 675 Brown Road

RADIOPHARMACEUTICALS Hazelwood . M 0 63042

= 18312MUIE@T

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The new Elscint Dycom 80 is one oftoday's most advanced,convenient and useful diagnostic image processing systems. It'sso advanced, it will take you through the 1980's with ease.

It's the easiestsystemfor the nuclear medicinespecialisttouse. All required operator input is clearly spelled out, step-bystep,on a largeCRT monitor. There's no need to refer to a“command―instruction book, a feature which savesthousandsofhours and significantlyimprovespatient throughput.

Another easy-operation feature: entr@rof a single number orletter starts anydesiredoperation.No time-consumingtypingoflengthy input data is required.

Capacity? The Dycom 80 provides storage and retrieval for15,000patient records,with absolutedata securityandpositivepatient I.D. at all times.

The system has a large 10 megabyte image and ROl storage

138-160JohnsonAve.(P.O.Box832),Hackensack,NJ.07602,Telephone(201)487-5885In France:Elsci.t S.A.LL.,I 1 Rue(ftuard-Lefebvre70000VersaIllesT•Ip@.ne:950-2767.In Germaey:(lade) GII*N, Freudenbrn'gstrasse27, 62 Wiubad.n4cIIierstein,Telephone:(06121) 2786. In U.K.: Elacint (GB) Ltd. 5 Priestley Way, Crawley, Sussee OHiO 20W, Tele.phone: (0293) 21285/6/7. In Belgium: £Iaclnt ca/nv. Chausson de Waterloo Ne. 1023,Beite No. 3, 8-1160 Brussels,Telephone:02-375.13.54. In ether countrIes:Write to tlscintLtd., P.O. lox 5251, Haifa, Israel, Telephone:04-522516, 04-522651, Telex: 41654, Cable:(Iscint, HaIfa, for the efficein peercmintry.

capacitywhichisexpandableto 40 megabytes.The Dycom 80 provides an extremely broad variety of Image

Processing and Histogram processing procedures to help thenuclear medicine specialist obtain a more accurate diagnosis.Additionally,clinicalprogramsfor heart, lung,brain and manyother studies are provided.

Those on stretched budgets will find the system's modularstructurea big plus. The basic system is easily expanded toinclude many available features such as a larger CPU memory,additional displays,a widevarietyofimage printout devicesandother options.

Dycom 80, the image processing system that will take youthrough the 1980's.

Find out about it today. Contact us for a demonstration.

elscint Inc.Wherequality counts . . . count on Elscint

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Radiation safety is always a Compromise. The idealexposure is none. The proteCtive clothing shown isnot always practical.That's why we've “tamed―technetium and put it into a unit-dosesystemthatmakes it easierand safer to handle.

The CINTICHEM®Systemreduces both the radiation burden and the labor of imagingagent prepara

tion by effectiveshieldingand by automatingisotope measurement,dose volume calcula

tions, dose preparationand final doseassay.

RELATiVEABSORBEDRADIATiONDOSE(inmrem/hr)

Source of Data: F D. Rollo,M.D.,PhD., Associate Professor ofMedicine& Radiology,Universityof California,SanFrancisco,andDirector,NuclearMedicineService.VeteransAdministrationHospital,SanFrancisco.Dataon file.

IDose

ration

DoseWithdrawal'

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HANDS161.6

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At the same time, it reduces the 24 typical steps in the manual methodof preparing the initialpatientdose—andthe 13 in subsequentdoses—tojust five each. The CINTICHEMDispenser constantly subtracts backgroundactivity and displays available technetium concentration, checks for molybreakthrough, makes two independent measurements of the dispenseddose, and signals you if anything's amiss.

Chances of reagent stability problems occurring are lessened and decaycalculationsare eliminatedbecauseeach dose is preparedas needed, notbefore. The unique lead glass syringe shield allows you to withdraw accuratedoses with rapid visual observation. And throughout the system, strict UnionCarbide quality control assures you of accurate, safe agent preparationwith dependable, rugged, precise equipment.

Youcan unburden yourself from radiationsafety problems in imagingagent preparation.The CINTICHEMSystemtamestechnetium to helpyou do it.

@‘@@@ Automated 99mTc Unit-Dose DelIvery System

SYSTEMATiCALLYSAFER.

call tolifree (800) 431-1146. Or write:

NM4

Union Carbide CorporationClinicalDiagnostics401 Theodore Fremd AvenueRye,NewYork10580

0 Send me literature on the CINTICHEM5ystem.0 Have your representative call for an appointment.

Name

Position-

Tel.area code ( ) Number

Medx Update-X uses the latesttec'hnologicaladvancesto updateyour existing Pho/Gamma®* HPor Pho/Gamma®Ill, providingresolution equal to the latest newequipment.

For far less than the cost of a newcamera, Medx will replace yourcomplete detector assemblywith astate-of-the-artunit providing:SGuaranteedstate-of-the-art1/8

inch intrinsic bar pattern resolutionfor99m Tc without compromise offield uniformity.

. Excellent resolution in the 69 to 83

KEy range ofThallium 201 , as wellasat higher energies 1311andother similar emitters.

S New state-of-the-art crysthi with

two-year ciysthl warranty.

SNewstate-of-the-artPhotoMultipliertubes and system optics.

SFullyupdatedelectronicsthroughout.

. Full one-year camera service

warranty.

Medx Update-X is done on an echange basis and can be instalksiteduringjust one day.Youreaorder is necessaiy to insure prordelivery. Prices are subject to ch@Lease plans are available.

MedicUpdate-X for yourPho/Gamma®HP $19,500

Medx Update-X for yourPho/Gamm&@ Ill $2 I ,950

Medic also has complete GariCamera systems that include thiUpdate-X plan starting at $39,5

MAILCOUPONTODAY!in ahurry?Callcollect312/991-0660

Please contact usaboutthe follo@4ng:0 Pho/Gamma®II' system.0 Pho/Gamma®UIsystem.00

IIUUUIIIII

Complete Gamma CameraSystemincluding Update-XP@aseaddourname toyourmailinglistforfurther information aboutMedx (Jpdate-Xand0 cameras@ scanners@ ultrasoundC) otherinstrumentation.

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$19,500Medx Update -XNew Gamma Camera

botop.Activity In Viol(xposur.at

Surfoce of Viol ShieldAft.nuoeonFactor99M1C14

Cl1OMR/Hrt1MillionNRC( 1) So CiI4CRP(2) 72Ci67

G@2.8 MO10Mt1JH1@300NRC(1)110mG

rICRP(2) 14.2 mC

ô7GA0.94 MO10MIVHR100NRC(1)35mG

NCRP(2)4lmCi

NcM@from the samecompanythat developedthe firstsyringeshieldwith total visibiit@tv@osafe,totalvisibilityvialshields.In addition to eliminating shielding leakage each unitprovides:360degreevisibilityfor fast,certainsyringefilling.Assured safety from Nuclear Pacific's @nI-h@D®

(62gm/cm@)leadglass.

Automatic centering action to position vials and holdthem steadyfor safedosageremoval.

Removable twist-lockcaps for easy cleaningand needleinsertion.

Units accommodate all vials regardless of thameteilength or cap sizeup to and induding 30m1size.The bases unscrew to allovjvial replacement.

Specifications:

‘actor

8 000N1@C(1) 450mCiNC'@' “@@

131 I 0.25 MONRC(f) 10mGNCRP(2) 12 mCi

10MW@in 1311 0.49M0NRC(1) lQmCiNCRP(2)25mCi

$275 ea, EO.@ Seattle.

10MR/HR50100

$225ea, Fo.B Seattle.(1) NRCmox perm.ssobie dose—honds—18 75 rems/quorter.(2) NCRPReportNo 3'?Maxperm,ssobiedose—honds—25 rams/quarterBoth above converted to 8 hours/day C,60 days per quarter

For additional information, contact Nudear Pacific,Inc. 6701 SIxth AvenueSo. Seattle, Wa.98108 (206) 763-2170‘RegisteredU.S.PatentOffice.Platinummeltedultra high densityopticalglass.

Nuclear Pacificintroduces two new ways

to see what you're getting into.

NUCINPmcmc,

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Modern diagnostic procedures in nuclear medicineare presenting more challenging situations whichtax the capabilitiesof commercial instrumentation.Here is one way in which Ortec is helping to solvethese problems:

Dr. Robert E. PolCyn, Director ofNuclear Medicine at the University of Wisconsin MedicalSchool, says: “Mostcommercialnuclear medicine instrumentstendtoperforma singleclinicaltask.The result is a large inventory of little-used systems.

“Ourapproach at the University,on the otherhand,istoemphasizeinstrument function,stockinga number ofresearchgradeNIM modulestoconfigurethe systemwe needfor any particular requirement.This modular approach has resulted inimproved energy resolution andcount-rate capability, cost sayings, and increased reliability. Inaddition, we now have the flexibility to adapt our systems to ourchanging clinical needs:'

Forcomplete informationon Ortec instrumentsfornuclear medicine, write or call Life Sciences Dlvision,OrtecIncorporated,100 MidlandRoad,OakRidge,TN 37830;(615)482-4411.

6906°OrtecSee us at Booth B, Society of Nuclear Medicine Meeting.

ModularO@ecinstrument@ do more,do it better@

.@ inc@ase your fIexibiIi@.@

Providing solutions. DRTEC@, ANJ!@EGG COMPANY

16OFFICESIN49COUNTRIES

featuring. The production of whole-body emission and trans

mission, tomographic and rectilinear Images.. A completely self-contained user-oriented operaHon.

. The use of posftron-emittlng radlopharmaceuticals.

. Modular electronics, designed for ease of serviceandhighreliability.

. Rapid, flexible scan capabilities, automatic bedindexing,high-resolutiondisplay,andadaptableciataprocessing.

The ECAT(Emission computerized Axial Tomographic)whole-bodyscannerusespositron-emittingradiopharmaceuticalsfor patient imaging.

Developed and manufactured by the Life SciencesDivisionofOrtecInc.. theECATrepresentsanaccumulation of the extensive line of research instrumentswhichOrtecsupplies.DataacquisitionisachievedwithstandardNIMandCAMACmodulesidenticalto thoseproven reliablethroughout the world in research.industrial,andclinicallaboratories.It isthismodularapproachthat not only helpspreventobsolescencebutalso provides for ease of service should the need everarise.

TheECATmeasuresand locatesthe concentrationofa positron -emitting radiopharmaceutical compound.suchasssGa-EDTA, 1l@@jor 3NH3,administered tothe patient.Whena positronannihilates.two gammarays are emitted in opposite directions By detectingthesegamma rayswithelectronicallycollimatedopposing detector banks. the ray projection in whichthe annihilation occurred is determinedThis method of detection provides forhigh resolution, high contrast.

and high sensitivity in a format uniquely suited to reconstruction tomography. Compiling, sorting, andprocessing these data with a reconstruction algorithmresults in a cross-sectional image similar to theimagesgeneratedbytransmissionCAT(TCAT)scanners.Thedifference is that Ortec ECATimagesare a measure of the physiology, or function, rather than themorphology, or density, of the structure.

Formoreinformation.callorwriteLifeSciencesDivision,OrtecIncorporated,100MidlandRoad.OakRidge,TN37830;(615)482-4411.ECAI trademark owned by Ortec Incorporated.

6884

See us at Booth B, Society of Nuclear Medicine Meeting.

THE

@c@

EmissionComputerizedAxialTomographic

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ORTEC®AIrJ@@EGcG CORIPAI.IV

76 OFFICES IN 49 COUNTRIES

I/

Nalge introducesthe FILMWARETMScintillationTubesystem for equivalent counting efficiency, plus exceptional@economyfromcarrier to cocktail.

The new Nalge FILMWARE Scintillation Tube revolutionizes liquid jscintillation counting by combining the advantages and eliminatingthe disadvantagesof glass and plastic vials.

Like glass, FILMWARE tubes are transparent. Like glass, theyhave extremely low permeability to toluene. But they permit noadsorption of liquids, proteins, or ions to change the geometryof the system. And FILMWARE tubes contribute a backgroundof less than half that of low-potassiumglass.

Like plastic, FILMWARE tubes are unbreakable. But,madeoftwo layersof plastic, they're500 times less permeable to toluene thanpolyethylene. And they can't swell, jammingthe counter and creating the hazard of fire.

Heat-sealedFILMWAREtubes eliminate thedanger of contamination when vials breakduring troublesome capping, and they costlessthan replacementcaps—about2.8@apiece.

[

Thecountisthesame.Thecostisnot.

/‘

Newgeometryfor real economy.What's more, you save by using less

cocktail. FILMWARE tubes are available.rn3-mi and 10-mi sizes, but they provide anaccurate count with as little as 1 ml of cocktail.In the tube, 1 ml is distributed vertically, toassure optimal exposure to the photomultiplier. The 10-mi tube easily accommodatesfilter papers, yet you need only 1-2 ml ofcocktail for an efficient count.

One-sixththe disposalvolume.With FILMWARE tubes, you reduce the cost

and volume of disposal, too. Over 12,000samples can be emptied into a standard drum.Six times more than is possible when you useglass or plastic vials. FILMWAREtubes canbeincinerated,leftintact,orsnippedopenforemptying. cost savingsare estimatedat 75%.

....@,@

Nalge CompanyDivision of Sybron Corporation

1. Place FILMWAREtube into a wide-mouthvial.2. Dispense as little as 1 ml of cocktail into tube. 3. Pipetsample into each tube. 4. Seal the tubes shut. 5. Tucktubes down into carrier.

The elements of the system.counting with the Nalge FILMWARE

Scintillation Tube takes no longer than thesystem using standard vials. FILMWARE tubesare specially designed to stay open foreasy filling.

The optional, reusable carrier vials arestraight-walled, for easy insertion of the tubes.

The optional, three-tiered rack provideseasy access to the tubes for filling and holds10-mi FILMWARE tubes without thecarrier vials.

The heat sealer seals the tubes in about2 seconds. It operates at 350°F, well belowthe ignition temperature of toluene. Tubes canbe resealed after an internal standard isadded by snipping the tops or puncturingthem with a syringe.

I Count your savings.

Application of the NalgeFILMWARE Scintillation Tubesystem can lower liquid scintillationcounting costs dramatically, eventhough current cocktail, vial, and... .1costsvary.Tolearnhowie systemcancontributeto your

counting operation, contact your Nalge representative. And for an explanatory brochure,write: Nalgene Labware Division, P.O. Box 365,Rochester,NewYork 14602.

SYBFION@ Nalge

Radx has now programmed its new Meletron to read its owncalibration factors.The Meletron programmablemicroprocessorallows you to check each of the Isotope Selector Keys for proper multiplication factors.

Radxemploysdirectmathematicalmanipulationfor thevanous radionuclides (other dosecalibrators vary the resistance toalterthesignalfromtheionizationchamberto thedigitalmeter)and thesefactorscannow be recalledfrom memoryand dlsplayedon the digitalreadout. Since each radionudide has afiniteanddiscretemathematicalfactor,theabilityto recallanddisplay this factor (as triggered by the Isotope Selector Key) willremove any doubt concerning this aspectof dosecalibration.

Arearadiationcanalsobe monitoredbythe new Meletron. With the key out,“Background—Error―will flash when theradiation level exceeds approximately2.0 mr/hr (withan unshielded unit).

AreamonitoringIsstandardon Meletron;an extra costoption on other dosecalibrators.

Hard copy data of your radionucide calibrations is anotherRADX first The Melecord prints; time, date, volume, calibralion, patient dose, radionuclide —plus it calculates and thenprints the volume to administer. Easy compliance with NRCrequirementsis also assuredby Melefile,the RADX recordkeepingsystemwhich providesdata cards,tab cardsand acompactfile to keep them in.

Obsolescence is eliminated. The Meletron employs the latestin microprocessor technology. The highly reliable microprocessor is readily programmable to perform a wide vatlety of functions.Further program modificationsmay be added to your unitin the field, as they are developed.

For a permanent solution to yourdosecalibration and record -keepingproblems,callRADX—the Innovatorsinnuclear medicine. RADX, P. 0. Box19164, Houston, Texas 77024, 713/468-9628.

@E@D@C

-4

11

Melétron& Melécord . . . your key to accuivte.. dosecallbratlonanderror-freerecords.

Mekftron

The dosecalibratórthatcalibrates itself (almost)

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Proven, reliable...more than300 ADRSystems in clinical use.

Formoreinformationor a livedemonstrationatyourconvenience,contact:

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NewFeatures:

. Wide-range gray scale

10shadesofgray,formoredefinitive imaging

. 120-line display, for evenbetterresolution

. Automatic photo control,for improved still pictures

S Electronic calipers, for

quick,accuratemeasurements

. Still less than half the costof conventionalBscanners Scars co@nesy of UIt,.@owxi Dag@ostc S,@ces Phort@. Ar@zora

If this were the actual screen display,youwouldseethefetalheartbeating.

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The organ and skeletal systems of the body make up a magnificent, well organized systemof highly specializedcomponents, each of which provides effident and dependablefunctions.ACKERMANNUCLEARINC'sonly function isto specializein the development,refinement and production of Cold Kit imaging reagents, because we believethat kind of specialization produces the most efficient and dependable results.

ACKERMAN NUCLEAR INC. is the only company in the field whose sole business is producing Cold Kit imaging reagents. The ultimate organized system willbea kit for eachorganandfunctionof the body. We are making progresstoward this goal with the largestvariety of Cold Kits in the nuclear medicineindustry.

C@ERMANNUCLEAR INC.N I PharmaceuticalsforNuclearMedicine

445 West Garfield AvenueGlendale, California 91204, U.S.A.[213] 246-2555

For more detailed information, call or write:

AWeII Organized System

data muchofwhich ispublished in our literature.We offer, for example, @Seselenome

thionine, 67@ citrate, @mTcand@ @3mlngenerators, and a wide range of iodinotedcomr@@ including 125@@l@Jfibrinogen.Our@ - ogue also lists a number of uniqueprc :ts like the Dicopoc@kit,a valuable aidin' @â€y.

.@ 1,any more. Why not write

@rcatalogue.

Perhaps that is what we should be called.Because The Radiochemical Centre is one

of the largest radiopharmaceutical producersin the world It also has a large research anddevelopment programme for new products inthe diagnostic therapeLt arch fiekis

Bysethng ourselves rd ofProduction and (@you of4he reliability cforma. -@@@@ validated

TillFull information @savailable on request

The RadiochemicolCenfre Limited Amersham England Telephone 024 04 4444In W Germany Amersham Buchler GmbH & Co KG Brounschweig Telephone 05307469397

Trade mark 0825

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E@I@TIT[@a@i@Radio-Labware CleanerThe most effective solution anywhere offered for cleansing hotlab apparatus of adherent radioactivity. Safe and easy-to-use.Proves itself thousands of timbs daily in research and clinicallaboratories throughout the world.

Now available at reasonable cost, internationally, through Iicensed manufacture to Isolab's exacting specifications, plusnational distribution from local stocks.

Contact your nearest Isoclean licensee or distributor for cornplete information.

NISOCONCENTRATE

WESTERNEUROPEBIOLABS. A.Ave. Michel-Ange81040 Brussels, Belgium

IBERIAN PENINSULAATOMPaseodel Monte,34Barceiona-12, Spain

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AUSTRALASIAS.R.E. Pty. Ltd.P.O.Box 69PennantHills, N.S.W.2120

In the U.S. and Canada: Order from any office of Amersham-Searle, Nuclear Associates, Picker and other distributors—or call Isolab collect.

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cables: ISOLAB AKRONTelex: 98-6475

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Subsidiaryof G.D.Searle& Co. Promptdelivery from ScientificProductsFosterCity,California94404 local stock. FisherScientificCo.800-227-0276 toIl free Curtin/MathesonScientificfrom California & Canada, VWR Scientificcall (415)573-1343

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Nowyoucantailorthe pipetteto yourapplication.Changesystemsin 15seconds,usingthe samehandle.

Dispense25timeswithoutrefilling.Loadand dispensewith one hand.

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LAO,DIASTOLE LAO.SYSTOLE

The RAOview shows akinesis of thelowerantero-lateral wall and apex;and contraction of the inferior walland high up the antero-lateral wall.The LAOview showsgood contrac

tion posteriorly and akinesisof theseptalaspectof the chamber. Patientwas injected IV with 2OmCi of@mTclabelledHumanSerumAlbumin.Theagent wasprepared using the New

England Nuclear Electrolysis Kit forlabelling HSA. Write or call for a portfolio of Brattle-gated lung, liver andheart studies.

Some Brattles have been in clinicaluse for over three yearsin community and major hospitalsMore than half of our instrumentsare in community hospitals and thelist isgrowing rapidly. Upon request,we'll supply names of happy users inyour area.

What's the next step?GetintouchAsk your NEN man about Brattles andHSA Kits. He can show you a portfolio of clinical pictures and arrangeto have one of our people give you ademo. Or write or call us direct. We'llsend you brochures on this and othermodels, and will give you your ownsetofclinicalpicturesandabibliographyongatedscintigraphy.Ifyouwish, we'll evenmakeyou a Brattleowner. (This is the best part ofour story.)

No knobs, no meters, no errorsThe spartan panel above tells thesecond-best part of our story. If youwantto photographpeaksystole,press the SYSTOLE button. If, say,you want systoleonly at full expiration, press the EXPIRATIONbuttonaswell. Ifonlybreathingisrelevant,don't press the heart button.

The Brattle is connected to thepatient and to your gamma (or x-rayor ultrasonic) camera.Wheneverthepatient is in the selected phase,boththe scope and the scaler on yourgammacameraaregated ON,andfilm isexposed.Otherwise,theyare OFF.

Brattles lock onto patients-.andstaylockedonIt doesn't matter if the patients heartrate and breathing depth changewhile he's under the collimator be

cause we stay right with him. BrattIes contain an ECG to track heart, aplethysrnograph to track respiration,and a tiny computer to deduce systoleand diastole times from the heartsignal. And because it's all built in,your operator neednot beaphysiologist.

We don't cover our trackswe print themThepanel lights flash wheneverthepatient reaches the selected phases;and pushing the RECORDER-ONbutton gets you an ECGtracingmarked with breathing and cameraon times. Youcan verify function before, during and after exposure.

Asinglepairofaxillaryelectrodescaptures both heart and breathIt's easy. And we supply disposable,pre-filled electrodes.

Theequiprnent will be demonstrated at SNM National Meeting, Chicago, at Peninsula E. I

Help your cardiologiststudy heart kineticsnon-invasively with Brattle-gated scintiphotos.

1@:RAO. DIASTOLE RAO. SYSTOLE

Brattle Instrument Corporation243 Vassar Street . Cambridge, Massachusetts 02139 •617-661-0300

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IN@i1@Lti!iIC@CARDIAC@II$M1T@T$@TilE@ /CoiR@Gcn@i@cPROBE.

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@ When it comes to innovation inI thefieldofdiagnosticnuclearI medicine,youcanalwaysI dependonSearleRadio4@ graphics to bring it to you.

And our new Gamma/CorRCG Cardiac Probe is aperfect example.

Here, for the firsttime,is aportable, minimally invasivemethod for rapid and directmeasurement of leftventricularejection fraction. It utilizes avolumetri@cradionucide technique right at the patient'sbedside and, unlikeotherinstrumentation.it provides allessentialdata diredilyon aneasy-to-read strip chart.

The Gamma/Cor RCGCardiac Probe is yet one moreexample of Searle's expertise ir

@k the field of nuclear instrumen@‘tation.Andwhencomes

L I to new dimensions in nuclear

@ â€cardiologySearlebringsthem‘ to you first.

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