2009 ANNUAL REPORT - Office of Academic Affairs

Respectfully submitted by: PHPID Lead Dean: Chip Souba, Lead Dean College of Medicine, [email protected] , 2-2600 PHPID Steering Committee: Larry Schlesinger, Chair of PHPID College of Medicine, [email protected], 3-5666 Tim Buckley College of Public Health, [email protected], 3-7161 Michael Lairmore College of Veterinary Medicine, [email protected], 2-4489 Ken Lee College of Food, Agricultural, and Environ. Sciences, [email protected], 2-7797 John Reeve College of Biological, Mathematical, and Physical Sciences, [email protected], 2-2301 Mo Saif College of Food, Agricultural, and Environ. Sciences, [email protected], 3-3743 Bill Saville College of Veterinary Medicine, [email protected], 2-8553 Karl Werbovetz College of Pharmacy, [email protected], 2-5499 Mary Ellen Wewers College of Public Health, [email protected], 2-3137 PHPID Administration: Eric Lutz Program Manager, [email protected], 2-2590 Ann Florentine Fiscal Officer, [email protected], 3-3912 Christine O’Malley Program Communicator, [email protected], 3-9406

TARGETED INVESTMENT IN EXCELLENCE

PUBLIC HEALTH PREPAREDNESS FOR INFECTIOUS DISEASES

THE OHIO STATE UNIVERSITY

2009 ANNUAL REPORT

mailto:[email protected]













Program Annual Report, 2009 Year Three

2009 Annual Report

A Collaborative initiative of the colleges of Biological Sciences; Food, Agricultural, and Environmental Sciences; Medicine;

Pharmacy; Public Health; and Veterinary Medicine - www.phpid.osu.edu

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Executive Summary Over the past year, events such as the Salmonella in peanut butter outbreak, increasing global spread of human infections with Avian Influenza H5N1, and rising multi-drug resistant agents like Methicillin-Resistant Staphylococcus aureus (MRSA) in hospitals, communities and agriculture underscore the importance of vigilant ‘global-centric’ infectious disease and public health preparedness research, education, and service efforts. The growing divide between the importance of public health preparedness and infectious diseases research in today’s domestic and international economic climate and the diminished resources for public health and social programs is leading to further stresses across hospital and community healthcare delivery systems, social services, and regulatory and oversight agencies. These acute and chronic global needs are being met through the multidisciplinary efforts of the Public Health Preparedness for Infectious Diseases (PHPID) Program. Through the continued activities of the PHPID Program, an environment exists across The Ohio State University (OSU) where domestic and global public health preparedness and infectious disease challenges are met everyday by ‘trans-institutional’ teams of community-based, emergency management, public health preparedness, and infectious disease scientists. The PHPID is bringing together once-silo’ed infectious diseases and public health preparedness communities across the University. This strengthening of the efforts has brought further recognition to OSU as a national center for infectious disease and public health initiatives. These efforts are driven by the 125 PHPID affiliated faculty across six member colleges [Biological, Math and Physical Sciences (BMAPS); Food, Agricultural, and Environmental Sciences (CFAES); Medicine (COM); Pharmacy (COP); Public Health (CPH); and Veterinary Medicine (CVM)]. This effort continues to have unprecedented scope and scholarly impact. The PHPID mission of protecting public health by minimizing zoonotic, sapronotic, and food-borne infectious disease threats through innovative interdisciplinary research continues to be achieved. The intra-collegiate infrastructure established for the PHPID program has resulted in significant achievements directly attributed to this program in 2008, including:

• Recruitment of six additional PHPID program faculty: Dr. Daniel Wozniak as a full professor in the Division of Infectious Diseases, Department of Internal Medicine, COM with a split appointment in the Department of Microbiology, BMAPS; Dr. Mark Drew in the Division of Infectious Diseases, Department of Internal Medicine, COM with a split appointment in the Division of Medicinal Chemistry and Pharmacognosy, COP; Dr. Abigail Turner, in the Division of Infectious Diseases, Department of Internal Medicine, COM; Dr. Rebecca Garabed in the Department of Veterinary Preventative Medicine, CVM; and the imminent recruitments of Drs. Li Wu and Xin Li in the Department of Veterinary Biosciences, CVM. This now brings the total number of faculty hired through the PHPID to 10.

• New PHPID Graduate Education Fellowships supporting doctoral work that spans multiple

colleges. In 2008, Mr. Jason Marion, CPH, was awarded for his proposal to investigate the safety of recreational waters throughout Ohio. Subsequently, Mr. Marion and his advisor Tim Buckley (PI, CPH) used the framework of this project to win $171,000 in extramural funding from the Ohio Water Development Authority (OWDA) and an opportunity to present at the EPA’s National Beaches Conference in April, 2009. Ms. Smitha Pillia, CFAES, advised by Dr. Chang Won Lee (CFAES), was awarded for her work on viral and host factors involved in the interspecies transmission of avian influenza with two early publications.

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Continuing Graduate Education Fellowships. The 2007 Fellows continued to demonstrate excellence in science throughout 2008. Erin Rottinghaus, awarded for her proposal to investigate immune function in old age aiding the design of new vaccines and therapies for the elderly to combat respiratory infections has published her work (EK. Rottinghaus, B. Vesosky, J. Turner. IL-12 is sufficient to promote antigen independent IFN-γ production by CD8 T cells in old mice (Immunology, In Press). She was awarded 1st place in the Biological Sciences division of the Edward F. Hayes Graduate Research Forum, received 1st place for her graduate student poster presentation at the Center for Microbial Interface Biology (CMIB) retreat, and graduated with her Ph.D. in March, 2009. Mr. Robert Crawford awarded for his proposal to understand how the gallbladder environment influences the carriage of Salmonella typhi (cause of typhoid fever) toward prevention and treatment of this disease. In 2008, Mr. Crawford’s research abstract was selected for press release by the American Society of Microbiology (ASM) General Meeting in Boston and he received the 2008 Edward F. Hayes Graduate Research Forum Award (2nd Place Interdisciplinary Poster Competition). Rob also published the following manuscripts: Crawford, R.W., D.L. Gibson, W.W. Kay, and J.S. Gunn. 2008. Identification of a bile-induced exopolysaccharide required for Salmonella biofilm formation on gallstone surfaces. Infect. Immun. 76 (11): 5341-5349 (* Manuscript chosen for journal Spotlight. Infect. Immun. 76 (11): 4793-4794 and * Image selected for journal cover art, with caption. Infect. Immun. 77 (1); and Crawford, R.W. and J.S. Gunn. 2009. The interaction of bile salts with pathogenic and non-pathogenic intestinal bacteria. In L.A. Jaykus, H.H. Wang, and L.S. Schlesinger (ed.), Foodborne Microbes: Shaping the Host Ecosystem, 1st ed. (* Illustration chosen for book cover image, with caption).

• Through the award of two additional Pilot Research Grants (new), teams of intra-collegiate

faculty are focusing on relevant areas of infectious disease assessment, treatment, and preparedness; such as Dr. Jianrong Li’s project team, involving CFAES/CPH, CVM, Ohio Agricultural Research and Development Center (OARDC), and COM/Nationwide’s Children’s Hospital, is investigating a new vaccine strategy against non-cultivable foodborne viruses using Vesicular stomatitis virus as the vector to deliver human Norovirus virus-like particles. Additionally, Dr. Ian Davis’ work involving effort across CVM, COM, and COP is investigating Nucleotide synthesis inhibitors as novel therapies for hypoxemia induced by influenza virus infection.

The 2007 grant recipients are continuing their efforts, as evidenced by Dr. Tim Buckley’s

characterization of NDV aerosolization behavior; Dr. Jesse Kwiek’s establishment of cross-university educational programs stemming from his collaborators in Malawi; Dr. Armando Hoet’s efforts characterizing animal involvement in MRSA transmission; Dr. Song Liang’s work in the Poyong Lake Region of China evaluating the ecologic and epidemiologic impact of the 3-gorges damn; and Dr. Mac Crawford’s novel infectious disease response training simulations for public health professionals.

• In 2008, infectious disease and preparedness-related external funding awarded to PHPID

investigators increased by 9% over the dollars received in 2007 and 34% over 2006 levels received by the same group. Additionally, PHPID-affiliated researchers have succeeded in increasing their success rate in receiving extramural funds across the spectrum of national and international agencies, both public and private. Based upon the comparison of total dollars in grants submitted versus grants awarded, program faculty have enjoyed increasing success in obtaining funds from 2006 through 2008 at 8%, 10%, and 11%, respectively (during a time when

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obtaining such funds has been extremely difficult). Also this year, the PHPID tallied an additional 8 specific translational and commercialization milestones achieved by PHPID-affiliated investigators, in the forms of patents awarded, commercialized products/services brought to market and intellectual property arrangements.

The PHPID has partnered with other internally-funded and externally-funded programs across campus of comparable mission to leverage PHPID resources providing new and expanded opportunities for pilot research. Some examples include:

• New Partnership between PHPID and the NIH Clinical and Translational Science Award (CTSA) funded OSU Center for Clinical and Translational Science (OSU CCTS) for three PHPID/CTSA Pilot Research Grants in the areas of clinical and translational infectious disease and public health preparedness research. The awardees include Drs. Jiyoung Lee, Jianrong Li, and Melvin Pascall. PHPID funds to support this partnership were captured from salary savings from the FY08 filled faculty positions. More information is available at http://phpid.osu.edu/phpid/?q=node/148.

• Creation of a new MEPS/PHPID/RNA Center Infectious Disease Graduate Student

Fellowship, awarded to Yu Zhang, doctoral candidate of Dr. Jianrong Li of CFAES/CPH, in support of his work investigating messenger RNA cap methyltransferase in paramyxovirus. PHPID funds to support this partnership were captured from salary savings from the FY08 filled faculty positions. Of note, the RNA Center Graduate Student Fellowship program was modeled significantly from the PHPID Graduate Fellowship Program.

• The PHPID continued the partnership with the Climate Water Carbon (CWC) TIE by continued

communication and strengthening of the relationships across the TIEs and continued efforts by PHPID/CWC Pilot Research Grant recipients, John “Mac” Crawford (PI) and Song Liang (PI), furthering the scientific linkages and academic interface between the two groups.

The PHPID, with significant support from the PHPID Lead Communicator Christine O’Malley and Melinda Swan of the Office of University Communications, continues to improve outreach efforts to audiences spanning the lay public, University faculty and administration, and state government agencies. For example:

• Continued enhancement of internal and external communication through the PHPID website (www.phpid.osu.edu).

• State Representatives Meeting. Through the coordination of Jennifer Carlson of the Office of

Health Sciences and Melinda Swan, the PHPID Steering Committee met with State of Ohio representatives from the Office of Emergency Management, the Health Department, and the Department of Insurance with the goal of understanding and supporting the preparedness and infectious disease-related needs of Ohioans. This initial meeting led to the enthusiastic call for continued communications between the groups. Among the strategies discussed was the well established inter-agency Applied Epidemiology Program (AFEP) directed Bill Saville, Chair of Veterinary Preventative Medicine, CVM and PHPID Steering Committee Member, as the model.

• Efforts at further integrating PHPID faculty were made through the PHPID Annual Membership

Meeting in June, 2008, and a New PHPID Faculty Introduction Meeting in November, 2008. Each event had 65% and 45% membership attendance, respectively.

http://phpid.osu.edu/phpid/?q=node/148

http://www.phpid.osu.edu/

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PHPID Implementation, Goals, and Metrics Governance of the PHPID is provided by the unwavering commitment of the PHPID Steering Committee (SC, Figure 1), which established the foundational mission of the PHPID: a program that strives to protect public health by minimizing zoonotic, sapronotic, and food-borne infectious diseases threats through innovative interdisciplinary research. Based upon the framework established by the SC as described in the 2006 PHPID Implementation Plan (Appendix A), the affiliated colleges are leveraging the strengths of established infectious disease programs and Centers (Figure 2) with resources garnered from the TIE award to “form a seamless, unique, comprehensive and strategic program in public health”. The SC has identified the following five strategic goals to achieving the PHPID mission:

• Translating scientific discoveries into clinical applications e.g. new diagnostics, therapies, and vaccines for infectious diseases;

• Detecting the presence of emerging infectious diseases within communities, the

underlying mode of transmission, and strategies for prevention, control and treatment;

• Preventing human infection from antibiotic resistant zoonotic (animal-to-human) micro-organisms through an understanding of livestock immune systems – particularly the gastrointestinal tract – with an aim to reduce use of antibiotics in animals;

• Addressing food safety issues during food production, processing, transport, storage,

retail, or consumer use, with an aim to decrease infections and associated fatalities caused by food-borne illness; and

• Training professionals in veterinary public health and infectious diseases public health

preparedness.

Chip Souba, Lead Dean - COM Larry Schlesinger, Chair – COM Tim Buckley – CPH Michael Lairmore – CVM Ken Lee – CFAES John Reeve - CBS Mo Saif – CFAES William Saville – CVM Karl Werbovetz – COP Mary Ellen Wewers - CPH

Figure 1 – The PHPID Steering Committee Members *Note: one vote per College

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The mission and goals are the standard by which all program activities are measured. The PHPID SC meets monthly to continuously evaluate the effectiveness of activities by using the following metrics derived from the goals:

• OSU researchers facilitate and optimize interactions in serving as a local, state, national, and international resource for scientific and socially relevant input on issues relating to public health preparedness for infectious diseases;

• Pilot research grant funds promote faculty member interactions and reward cutting-edge

research leading to successful sponsored research awards from federal agencies, industrial partners, private foundations, and the State of Ohio (i.e. RCP, ORSP, OFSP);

• Colleges collaborate in trans-institutional programs to attract world class faculty;

• Faculty mentors attract the best graduate students worldwide. A PHPID graduate

training fellowship program supports and inspires outstanding pre-doctoral students;

• Publication of cutting-edge papers in the highest impact journals, high citations, awards, and exemplary service on national and international panels of significant scholarly merit;

• Research from the program is translated to applications that benefit public health, food

safety, and training of scientists and other professionals in public health preparedness for infectious diseases; and

• Development of technologies such as new therapies and vaccines, devices for

monitoring and disinfection of microorganisms in food, air, water, or fomites providing opportunities for commercialization and a positive impact on the economy of Ohio.

Figure 2 - Established OSU Infectious Disease Programs

• Applied Research for Improving Healthcare (HOPES). • Center for Microbial Interface Biology (CMIB). • Nationwide Children’s Hospital – Centers for Microbial Pathogenesis

(CMP) and Vaccines and Immunity (CVI). • Clinical Epidemiology Program (CEP). • Great Lakes Regional Centers of Excellence (GLRCE) in Biodefense

and Emerging Infectious Diseases Research Program. • Infectious Diseases Interest Group (IDIG). • Division of Infectious Diseases, Internal Medicine. • AIDS Clinical Trials Unit (ACTU). • Infectious Diseases Molecular Epidemiology and Detection

Laboratory (IDMEDL). • Food Animal Health Research Program, Wooster (FAHRP). • Center for RNA Biology (RNA Center) • Food Safety and Ag Security Center (FSAS). • Ohio Agricultural Research and Development Center (OARDC).

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Accomplishments from May, 2008, to April, 2009 As provided in the 2009 PHPID Program Summary Tables located in Appendix B, the PHPID activities from May, 2008 to April, 2009, directly address the seven metrics listed above. As detailed in the referenced tables, the PHPID activities of this period that are directly attributable to the program include:

• External Advisory Board – The PHPID SC is in the process of forming an external advisory board that will assist the SC in strengthening the program. This Board will be comprised of international scientific leaders representing the diverse disciplines within the PHPID. The candidates identified thus far are Drs. Tony Forshey (State Veterinarian of Ohio), Lester Mitscher (Distinguished Professor, University of Kansas), Gil Cloyd (Proctor & Gamble CTO and former Chair of OSU Board of Trustees), Harley Moon (Professor and Director Emeritus, Iowa State University, National Animal Disease Center, Ames, Iowa), Robert A. Clark (Assistant VP of Clinical Research, UTHCS), and Ellen Silbergeld (Professor and Editor and Chief, Environmental Research, Johns Hopkins Bloomberg School of Public Health).

• Appointment of Fiscal and Communications Officers – Ms. Ann Florentine,

Assistant Dean for Finance and Administration, CPH as PHPID Fiscal Officer and Ms. Christine O’Malley, Communications Director, CPH.

• Continued Support from the Program Lead Dean – Dean Chip Souba, COM.

• Continued Daily Program Management - Eric Lutz, PHPID Program Manager is

engaged in the daily fiscal, administrative and coordination activities of the PHPID program, including support of PHPID faculty recruitment efforts, PHPID membership, managing the PHPID Programs such as the Pilot Research Grant, Graduate Fellowship, and the new CWC/PHPID Pilot Research Grant, presentations regarding the PHPID, and web page design. Mr. Lutz’s CV is provided as Appendix C.

• Faculty Recruitment - Hiring of six additional PHPID faculty positions (Table 1,

Appendix B):

o Dr. Daniel Wozniak, Professor, CMIB, Department of Internal Medicine, Division of Infectious Diseases, COM with a split appointment in the Department of Microbiology, BMAPS;

o Dr. Mark Drew, Assistant Professor, CMIB, Department of Internal Medicine, Division of Infectious Diseases, COM with a split appointment in the Division of Medicinal Chemistry and Pharmacognosy, COP;

o Dr. Rebecca Garabed, Assistant Professor, Department of Veterinary Preventative Medicine, CVM;

o Dr. Abigail Turner, Assistant Professor, CMIB, Department of Internal Medicine, Division of Infectious Diseases, COM;

o (Pending) Dr. Xin Li, Assistant Professor, Department of Veterinary Biosciences, CVM;

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o (Pending) Dr. Li Wu, Assistant Professor, Department of Veterinary Biosciences, CVM.

o CVs for all ten new PHPID faculty members (4 reported in 2008 report and 6 reported here) are provided in Appendix C.

• Active Recruitment for Final PHPID-Funded Position – In the spring of 2009, active

recruitment of candidates has commenced for the Clinical Trials position, the final PHPID funded position. This position will be a 70% COM/30% CPH split appointment (Table 1, Appendix B). The open announcement and job description appears on the PHPID website (www.phpid.osu.edu). We are pleased to report our recruitment pace continues to be ahead of the Implementation Plan schedule.

• Development and Planning of an International Congress on Infectious Diseases –

Meeting the Infectious Diseases Challenges of the 21st Century – Through the significant efforts of the PHPID International Congress Committee, a white paper has been developed outlining the vision for this globally significant event projected for 2011/2012. The White paper is provided in Appendix D. The timing of this event is anticipated to strategically coincide with major infrastructure expansions in both the Medical Center and the CPH (Cunz Hall Renovation, completion in 2011).

• State Representatives Meeting. Through the coordination of Jennifer Carlson of the

Office of Health Sciences and Melinda Swan, the PHPID Steering Committee met with State of Ohio representatives from the Office of Emergency Management, the Health Department, and the Department of Insurance with the goal of understanding and supporting the preparedness and infectious disease-related needs of Ohioans. This initial meeting led to enthusiastic call for continued communications between the groups. One mechanism will be the well established inter-agency Applied Epidemiology Program (AFEP) directed Bill Saville, Chair of Preventative Medicine, College of Veterinary Medicine and PHPID Steering Committee Member, as the model.

• Graduate Fellowships - The 2008/2009 fellowship application process was streamlined

to a completely electronic format using the PHPID web page for user interface. As of April, 2009, the PHPID has awarded over $136,700 in graduate fellowships (Table 2, Appendix B). The 2008/2009 fellows are:

o Jason Marion (CPH), investigating the water quality and related safety of recreational waters throughout Ohio. Subsequently, Mr. Marion and his advisor Tim Buckley (PI, CPH) utilized the framework of this project to successfully compete for $171,000 in extramural funding from the Ohio Water Development Authority (OWDA) and an opportunity to present at the EPA’s National Beaches Conference in April, 2009.

o Smitha Pillia (CFAES/OARDC), advised by Dr. Chang Won Lee (CFAES), was

awarded for her work on viral and host factors involved in the interspecies transmission of avian influenza with two early publications (manuscript and an abstract); S.P.S. Pillia, M. Pantin-Jackwood, S. J. Jadhao, D. L. Suarez, L. Wang, H. M. Yassine, Y. M. Saif, C-W. Lee. Pathobiology of triple reassortant H3N2


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influenza viruses in breeder turkeys and its potential implication for vaccine studies in turkeys. Vaccine, 27: 819-24. 2009; and S.P.S. Pillia, M. Pantin-Jackwood, D. L. Suarez, C-W. Lee. The High Susceptibility of Turkeys to Low Pathogenic Avian Influenza Viruses of Different Origin Imply their Importance as Intermediate Hosts. 7th International symposium on avian influenza: Avian influenza in poultry and wild birds. The University of Georgia. Athens, Georgia. April 5-8, 2009.

The fellowship research proposal abstracts for both awardees are provided in Appendix E.

• Pilot Research Award – As of April, 2009, the PHPID has awarded $600,000 in faculty

pilot research support (Table 3, Appendix B). The 2008/2009 competition included 10 high quality proposals representing all 6 PHPID affiliated colleges and three external institutions. Two proposals were chosen for award as proposed in the implementation plan. The pilot grant research proposal abstracts for each awardee are provided in Appendix E. The 2008/2009 Pilot Grant Awardees include (PI):

Dr. Ian C. Davis of CVM for his project on Nucleotide synthesis inhibitors as novel therapies for hypoxemia induced by influenza virus infection. This project includes collaboration between the Colleges of Veterinary Medicine, Medicine, and Pharmacy. Dr. Jianrong Li of the College of CFAES/CPH for his project investigating Vesicular stomatitis virus as the vector to deliver human Norovirus virus-like particles, which strives to develop a new vaccine strategy against non-cultivable foodborne viruses. This project includes collaboration across the Colleges of Food, Agricultural and Environmental Sciences/Public Health, Veterinary Medicine, Medicine/Nationwide Children’s Hospital, and OARDC.

• Continued support of the trans-TIE partnership between the PHPID and the

Climate/Water/Carbon TIE. This active CWC/PHPID collaboration creates a synergistic CWC/PHPID pilot research grant opportunity for university faculty members. Now in year two, awardees Dr. Mac Crawford of CPH and Dr. Song Liang of CPH are showing significant progress. Project updates from both Principal Investigators are provided in Appendix F.

• New Partnership between PHPID and the NIH Clinical and Translational Science Award

(CTSA) funded OSU Center for Clinical and Translational Science (OSU CCTS) for three PHPID/CTSA Pilot Research Grants in the areas of clinical and translational infectious disease and public health preparedness research. The awardees include Dr. Jianrong Li et.al. ($100,000), for the project titled, “Methyltransferase-Defective Recombinant Viruses as Live Vaccine Candidates for Human Metapheumovirus: a Jump from Theory to Practice” spanning the Colleges of Food, Agricultural, and Environmental Sciences, Public Health, Medicine, Veterinary Medicine, and Nationwide Children’s Hospital; Dr. Jiyoung Lee et.al. ($50,000), for her work investigating, “Novel rapid detection of P. aeruginosa from liquid and aerosol samples in clinical environments” with effort across

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the Colleges of Public Health, Food, Agricultural, and Environmental Sciences, and Medicine; and Dr. Melvin Pascall et. al. ($50,000), for investigating, “Efficiency of Ware Washing Protocols for Removal of Foodborne Viruses from Utensils in Restaurants and Food Service Establishments”, representing effort across the Colleges of Food, Agricultural, and Environmental Sciences, Engineering, and the OARDC, Food Animal Health Research Program (OARDC/FAHRP). PHPID funds to support this partnership were captured from salary savings from the FY08 filled faculty positions. More information is available at http://phpid.osu.edu/phpid/?q=node/148.

• Creation of a new MEPS/PHPID/RNA Center Infectious Disease Graduate Student

Fellowship, awarded to Yu Zhang, doctoral candidate of Dr. Jianrong Li of CFAES/CPH, in support of his work investigating messenger RNA cap methyltransferase in paramyxovirus. The $10,000 in PHPID funds invested in this partnership was captured from salary savings from the FY08 filled faculty positions. Of note, the RNA Center Graduate Student Fellowship program was modeled significantly from the PHPID Graduate Fellowship Program.

• Capital Equipment Cost-Sharing Competition – To directly support the research

efforts of new PHPID faculty members and their PHPID-member faculty peers the program conducted a competition to provide four awards of $50,000 each in matching funds towards the purchase of specific capital equipment through leveraged salary savings. Equipment purchased included a Flow Cytometer (COM, Mark Drew), Ultra Centrifuge (CFAES, Jianrong Li), Q-PCR and SMPS (CPH, Jiyoung Lee), and a Flow Cytometer (CFAES/OARDC/FAHRP, Renukarahdya Gourapura).

• Program funds use follows the proposed activities specified in the Implementation Plan

and is within budget (Table 4, Appendix B). Table 5, in Appendix B, summarizes the current expenditures for fellowships, grants, and collaborative programs.

• Membership recruitment efforts have resulted in more than 125 OSU faculty members

now participating in the PHPID, strongly representing all six affiliated Colleges. Development of a comprehensive, key-word searchable, PHPID Membership Directory, including areas of expertise and contact information is available on the PHPID website (www.phpid.osu.edu). The second annual PHPID membership meeting was held on June 6, 2007, with approximately 65% of membership in attendance. This event was highlighted by presentations by the Graduate Fellows and Pilot Research Grant awardees. Consistent with the 2007 meeting, post-meeting evaluations identified that the cross-college networking opportunities was a high point. Additionally, a New PHPID Faculty Introduction Meeting was held in November, 2008. The mid-day event was attended by 45% of the PHPID membership.

• Website – The program continues to refine of the PHPID webpage (phpid.osu.edu).

Phase II added additional functionality, including blogging, private resource areas, and extensive search site capability.

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High Impact Contributions, 2008/2009 Continuing the momentum from 2007/2008, the PHPID-member faculty efforts in infectious disease and preparedness education, research, and service are increasingly impacting relevant stakeholders and being recognized by local, state, national, and international audiences. Significant leveraging with extramural grants and institutions continue to expand the reach of PHPID, providing high-impact, cutting-edge, translatable, and relevant research outcomes that is becoming synonymous with The Ohio State University. Highlights from selected 2008 high-impact activities include: Selected Grants:

• Membership of the PHPID has enthusiastically supported the Provost and VP for Research call for Innovation Centers and Groups through significant involvement, including submission of: Center for Water and Ecosystem Services, Center for Integrated Science and Precision Medicine, Food Innovation Center, Innovation Group for Drug Discovery against Infectious Diseases, and Innovation Group for Biofilms in Human Disease.

• Dr. Kurt Stevenson (COM) and his interdisciplinary team of investigators were awarded

a CDC renewal grant ($287,386) for Ohio State health network infection control collaborative: Epi-Centers for prevention of healthcare related infections.

• Dr. Michael Ibba (BMAPS) was awarded a grant from the NIH ($307,500.00) and from

the NSF ($276,750.00) for research investigating Biochemistry of lysyl-tRNA synthetases;

• Dr. Timothy Buckley (CPH) was awarded $157,558 from Ohio Water Development

Authority (OWDA) for the study: Protecting public health at Ohio inland beaches: Development of water quality indicators for recreational microbial exposures.

• Dr. Richard Slemons (CVM) was awarded a grant ($232,301) from the University of

Maryland for prevention and control of avian influenza in the US.

• Dr. Michael Oglesbee (CVM) was awarded a grant from the NIH NIAID ($224,840) for his work investigating heat shock protein modulation of paramyxoviral diseases.

• Dr. Karl Werbovetz (COP) was awarded a grant ($141,847) from the University of North

Carolina for his work developing new drugs to treat Leishmaniasis in late stage human African trypanosomiasis;

• Dr. Susan Koletar (COM) was awarded a renewal grant from the NIH NIAID

($1,223,531) for The Ohio State University AIDS Clinical Trials Unit.

• Dr. Joanne Turner (COM) was awarded a grant from the NIH NIAID entitled “Immune correlates of reactivation tuberculosis ($3,125,000). The goals of this project are to define the immunological signatures of susceptibility to tuberculosis. Correlates that are

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actively being studied are the role of IL-10 and CD8 T cells in driving tuberculosis disease progression.

• Dr. Daniel Wozniak (COM) was awarded a grant from the NIH NIAID “Control of P.

aeruginosa algD transcription ($2,241,000). The overall objectives of this study are to understand the molecular basis for high-level expression of alginate in mucoid P. aeruginosa strains and the coordinate regulation between alginate synthesis and motility.

Selected Education/Conferences:

• Through the efforts of new PHPID Faculty, two new cross-listed Public Health courses have been developed: Food Safety and Public Health (Jianrong Li) and Global Health and Environmental Microbiology (Jiyoung Lee). Additionally, courses were developed by Chang Won Lee titled VPM700 Application of Suspension Array Systems and VPM693 Opportunities in Veterinary Medicine in Korea and Jeff LeJeune titled Ani Sci 830.10 A Comprehensive Approach to Food Safety.

• National Conference - Food Safety and Public Health Frontier: Minimizing Antibiotic

Resistance through the Food Chain. The conference, co-sponsored by USDA-CSREES, OARDC and OSU extension, focused on a balanced scientific picture leading to antibiotic resistance in humans and strategies for targeted intervention. More than 80 experts from academia, government and industry, as well as representatives from EU, congressional fellow, leaders from USDA-CSREES, ARS, and FDA attended this important event. Dr. Hua Wang, associate professor from Department of Food Science & Technology and Microbiology and a member of the PHPID, served as the primary organizer and co-chair of the event. Several faculty members from OSU, including Tim Buckley (Public Health, member, organization committee), Valente Alvarez (Food Industry Center, speaker), Jeff LeJeune (OARDC, speaker), Lydia Medeiros (human ecology, speaker) presented at the conference.

• Dr. Prosper Boyaka (CVM) became National Program Chair for the “Mucosal and

Regional Immunology Section” of the 96th Annual Meeting of AAI. Selected Awards:

• Drs. Yasuko Rikihisa and Patrick Green (CVM) were elected as Fellows in the

American Academy of Microbiology.

• Dr. Larry Schlesinger (COM) was elected as a Fellow of the American Association for the Advancement of Science.

• Dr. Patrick Green (CVM) received the 2008 Charles C. Capen Excellence in Graduate

Education Award; Sample of the breadth of publications:

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• Dr. Jesse J. Kwiek et al. “The Molecular Epidemiology of HIV-1 Envelope Diversity During HIV-1 Subtype C Vertical Transmission in Malawian Mother-to-Infant Pairs”. AIDS, 2008, 22:863-71.

• Min Guo, Michael Ignativ, Karin Musier-Forsyth, Paul Schimmel, and Xiang-Lei Yang

Crystal. “Structure of novel tetrameric form of human lysyl-tRNA synthetase: implications for multisythetase complex and new synthetase functions.” Proc. Natl. Acad. Sci. USA, 2008, 105: 2331-36.

• Saif, YM. Diseases of Poultry, 12th edition textbook, Editor-in-Chief, 2008.

• Joshua Arnold, Bevin Zimmerman, Patrick L. Green et al., “HTLV-1 antisense-encoded

gene, Hbz, promotes T-lymphocyte proliferation.”Blood”;

• Hooker, Neal. “Dissecting Qualified Health Claims: Evidence from Experimental Studies.” Critical Reviews in Food Science and Nutrition, 2008, 48(2): pp. 160-176.

• Hoet AE, Caswell R, DeGraves F, Rajala-Shultz P, Gebreyes W, Saville W, Wittum T.

“A New Approach to Teaching Veterinary Public Health at The Ohio State University.” Journal of Veterinary Medical Education. 35(2):2008. 160-165.

• Costantini, V. and L.J. Saif. Viral hazards associated with swine waters: Calicivirus,

Rotavirus. In Fate and Transport of Zoonotic Bacterial, Viral and Parasitic Pathogens during Swine Waste Treatment, Storage and Land Application. 2008. Council for Agricultural Science and Technology, No. 29, Ames, Iowa (Book Chapter).

• Lee, C.W. and D.L. Suarez. Reverse Genetics of the Avian Influenza Virus. In Avian Influenza Virus. Spackman E.(ed.) Humana Press, Totowa, New Jersey. pp 99-112 (Book Chapter).

• Alekseev, K.P., A.N. Vlasova, K. Jung, M. Hasoksuz, X. Zhang, R. Halpin, S. Wang, E. Ghedin, D. Spiro, and L.J. Saif. “Bovine-like coronaviruses isolated from four species of captive wild ruminants are homologous to bovine coronaviruses, based on complete genomic sequences.” J. Virol. 2008, 82:12422-12431.

• Liang, S. Spear, R.C. Model-based insights into multi-host transmission and control of

schistosomiasis. PLoS Medicine. 5(1):2008. e23. Technology and Commercialization:

• Technology Commercialization Application: Lakritz, Jeffrey, CVM. Bos Taurus, CD163. UniProt Knowledgebase P85521. Lakritz J, Gerspach C, Bannikov GA, Premanandan C, Green-Church KB, Marsh AE. Submitted April 7, 2008.

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Candidatus Mycoplasma haemolamae partial sequence 16s ribosomal RNA gene. Submitted December 12, 2008. FJ527244. A. Marsh, J. Lakritz.

• Patent Filed: Jackwood, D. J. 2008. A real-time RT-PCR assay for the rapid detection

of very virulent infectious bursal disease virus (vvIBDV) strains. (Filed, U.S. Patent Office).

• Patent: Rajashekara, G., and Kapur, V. 2008. Application of recombinant fimbrial protein antigen for the diagnosis of Salmonella enteritidis infection in poultry United States Patent 6,495,334.

• Patent: Rajashekara, G., Kapur, V., and Kakambi, N. 2008. Application of recombinant fimbrial protein antigen for the diagnosis of Salmonella enteritidis infection in poultry. International Patent.

• Patent Pending: Rajashekara, G., and Splitter, G. 2008. Brucella melitensis mutants and methods # PO6114US (pending).

• Patent: Miller, S.A. Xu, X., and Rajashekara, G. 2008. Clavibacter Michiganensis Subsp. Michiganensis Bioluminescent mutants and application. U.S. Patent Appl No. 61/083,783.

• Patent Application: Peeples, Mark, College of Medicine, Research Institute at

Nationwide Children’s Hospital in Columbus. Peeples, M.E., Kennedy, M. and Ray, W. “Methods and Compositions Relating to Viral Fusion Proteins” (60/942,456). Provisional Patent filed with the USPTO June 7, 2007. Regular Patent filed as an International PCT (Patent Cooperation Treaty) Application (US2008/66223), June 6, 2008

Additional Metrics As the PHPID continues maturing, program success will be gauged by the direct PHPID metrics outlined above, as well as by several relevant indirect metrics, including (a) increase in infectious disease-related external funding received; (b) increase in infectious disease-related research proposals submitted by PHPID membership; (c) increase in grant success rates; (d) increase in the number of infectious disease-related publications in high-impact, peer-reviewed journals; (e) increase in the translation of scientific discoveries in the form of patents, intellectual property arrangements, and industrial collaborations; (f) increase in education, community service and outreach; and (g) increase in national ranking of the six PHPID Colleges (infectious disease-related whenever possible). External Grant Awards - As seen in Figure 3, 2008 infectious disease and preparedness-related external funding awarded to PHPID investigators increased by 9% over the dollars received in 2007 and 34% over 2006 levels by the same group. This is impressive since federal funding expenditures across 2006, 2007, and 2008 have remained flat and competition has

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increased. Appendix G, Table 4 provides a summary of PHPID member infectious-disease and preparedness-related external grant awards for 2008, based on ‘Start Date’. External Grants Submitted - In 2008, PHPID-affiliated researchers’ submitted proposals for work in public health preparedness and infectious diseases that totaled over $123 million (Figure 4). This was a 2% decrease from 2007 submittal dollars but remains a 3% increase from 2006. Appendix G, Table 5 provides a summary of PHPID member infectious disease and preparedness-related grant proposals submitted during 2007. Grant Success Rate – PHPID-affiliated researchers have succeeded in increasing their success rate for receiving grants across the national spectrum of national and international agencies, both public and private. Based upon the comparison of total dollars in grants submitted versus grants awarded, program faculty have enjoyed an increase in grants success from 2006 through 2008 at 8%, 10%, and 11%, respectively; so while the 2008 submitted proposals for work in public health preparedness and infectious diseases decreased from 2007, the effectiveness of our proposal efforts increased. This is in part related to the composition of the submitted grants which is optimizing the collaborative teams assembled, including faculty with a clear cut track record of excellence in research. Peer Reviewed Publications and Commercialization - In 2008, PHPID investigators across all six colleges are estimated to have published over 300 infectious disease and preparedness-related manuscripts in high quality, peer-reviewed journals. Also this year, the PHPID tallied an additional 8 specific translational and commercialization milestones achieved by PHPID-affiliated investigators, in the forms of patents awarded, commercialized products/services brought to market and intellectual property arrangements. This brings the program total to 16 patents, commercialized products/services, or intellectual property arrangements over the past two years. National Rankings – 2008/2009 is an off-year for external evaluations across the six PHPID Colleges. As reported last year, 2007/2008 was a period that the PHPID made significant positive impact on each of the six PHPID-affiliated colleges, as evidenced by independent national rankings (US News and World Report). For example, in 2008 BMAPS is ranked 42nd nationally and is the top ranked program in Ohio; the COP was ranked 11th (2005); COM is ranked 31st for 2008 moving up one notch from 32nd in 2007; in 2008 the CPH is for the first time ranked in the listing of the top 25 at number 21, and the CVM, ranking 6th in 2005, has moved up one slot to a national ranking of 5th in the US for 2008. We believe that the PHPID is contributing to this positive trend in College ranking by influencing the quality of the research and education being produced by each College and that the national perception of these activities reflects this reality.

Figure 3 - External Funding Comparison, 2006 - 2008

$9,019,650.88

$12,408,435.75$13,591,135.00

0

2000000

4000000

6000000

8000000

10000000

12000000

14000000

16000000

2006 2007 2008

Years

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Issues and Limitations The PHPID is clearly on-track to achieving its mission as evidenced in the previous sections. As we complete our third year of funding, the fruits of the effort and investment are only beginning to emerge. For example, for the six faculty hired this year, they are not likely to reach their full stride for at least another 2-3 years, i.e. after they have established their labs and collaborations. As we approach our final two years of central funding support, we recognize the following challenges.

1. There is strong and broad interest in sustaining the PHPID beyond its five year funding period. However, the program was not originally designed to receive funding resulting from member-faculty research and education activities such as salary recovery or grant indirect costs. We estimate that $350-400K will be required to maintain the Program Manager position and continue the pilot research and graduate fellowships. As outlined in the Sustainability Section below, the Lead Dean and Steering Committee will be working this year to develop a plan for sustaining the PHPID beyond 2011.

2. Our ability to centrally capture the achievements of individual members across

the six Colleges is an administrative challenge. The PHPID also identifies ‘commercialization’ and ‘economic impact’ as paramount metrics for future evaluation of the success of the program. Reconciliation against these metrics will be included in the next annual report.

During the current year, it was necessary to make a slight change in our faculty recruitment plan for the F7 Epidemiology position (70% CPH/30% COM). A hallmark of the PHPID has been a network of joint faculty hires that draws Colleges together around a central theme of PHPID. After attempting to fill the Epidemiology position (one of our highest priority positions) without success (candidates identified but not accepted for several, unforeseen reasons), the Steering Committee with support from the relevant College Deans, reprogrammed this position to 100% COM, allowing the position to be filled in a more timely fashion. Sustainability In the current budget structure the PHPID is unable to capture funds generated from faculty activities. As such, our Lead Dean Chip Souba has committed to work towards sustainability of the program through a formal Sustainability Strategy currently in development by the Steering Committee. This Strategy includes investment and partnership at both the College-level and

Figure 4 - Total Dollars of PHPID Research Proposals Submitted, 2006 - 2008

$119,453,411.00

$125,721,896.00

$123,395,687.00

$116,000,000

$117,000,000

$118,000,000

$119,000,000

$120,000,000

$121,000,000

$122,000,000

$123,000,000

$124,000,000

$125,000,000

$126,000,000

$127,000,000

2006 2007 2008

Years

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from Central Administration (University). It is anticipated that PHPID representatives will present the Sustainability Strategy to the Health Sciences Deans Cluster in the fall of 2009. Closing Comments

The face of infectious diseases- and public health preparedness-related research and education across The Ohio State University has changed much in 2008. The PHPID is putting students first through enhanced intercollegiate interaction and communications, resulting in the addition of new cross-listed course offerings and expanded opportunities for undergraduate student research. We have successfully recruited 6 high-caliber faculty members who are eager to leverage the intra-collegiate opportunities within the PHPID. Our faculty membership now have broader international reach through expanded inter-institutional collaborations and research activities as demonstrated by the ongoing and expanded projects with the University of Malawi, Chinese Center for Disease Control and Prevention, University of Zulia, Venezuela, and the Egyptian National Government. The PHPID’s impact on faculty success is evident by the improved grant success rate among member faculty. Our success is built on the dedicated involvement and unwavering commitment of our broad membership, affiliate colleges, and the University. The PHPID has embraced the concept of One Ohio State University by institutionalizing the intracollegiate public health preparedness and infectious diseases infrastructure across the University. Through continued support from the University, the PHPID is committed to expanding community relationships, commercialization opportunities, and to strengthening our involvement with policy makers, researchers, and educators across the state, nation, and around the world. Acknowledgements The Steering Committee wishes to thank Michael Sherman, Donna Hobart, Carol Whitaker, Melinda Swan, and the President and Provosts Advisory Council for their excellent advice, guidance, and efforts that have resulted in significant expansion of reach and impact for the PHPID in 2008.

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Appendix A

PHPID Implementation Plan

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Pharmacy; Public Health; and Veterinary Medicine

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Appendix A

Implementation Plan for Interdisciplinary Public Health Preparedness Program for Emerging Infectious Disease Threats: From Discovery to Application

The United States currently faces threats from several infectious diseases that if they occur may produce death and suffering in human and animal populations. Such diseases may be either naturally-occurring or intentionally introduced. Further, introduction of or re-emergence of certain infectious diseases will result in huge economic losses, political repercussions and, in general, produce great negative psychological impact in our nation. This Targeted Investment in Excellence (TIE) program in public health preparedness is focused on important infectious disease threats to the public health because it is a paramount preparedness issue and capitalizes on the unique strengths and capabilities of the Colleges of Biological Sciences (CBS), Food, Agriculture and Environmental Sciences (CFAES), Medicine (COM), Pharmacy (CP), Veterinary Medicine (CVM), and the School of Public Health (SPH). The implementation plan (IP) for the TIE reflects its mission to create excellence in interdisciplinary programs of research and education central to public health preparedness and infectious disease. The plan will harness the breadth and depth of OSU’s existing and unique academic and research programs in this area of extreme national importance. Accordingly, our IP weaves programs across six colleges together to form a seamless, unique, comprehensive, and strategic program in public health that will yield high impact discoveries and ultimately improve the human condition through enhanced public health. The IP will be developed in phases. The current plan is for Phase 1 that includes the first two years of a planned five year program. This initial plan is for the period 7/1/06 to 6/30/08 and includes 37 and 57% of the total TIE award for PBA and cash, respectively. At the heart of the TIE and central to its implementation is the Steering Committee (Table 1). This committee is made up of scientists from each college and provides leadership for the development and implementation of the TIE. This committee has evolved and worked effectively to develop the initial TIE proposal (CVM, COM, & SPH) and then expand and integrate relevant expertise from across the university (CFAES, CBS, CP). This committee has been responsible for the development of the current plan and will oversee its implementation. A key responsibility of committee members is to inform and advise their college leadership, i.e. deans and senior fiscal officers, and provide for their representation. This committee will meet once each month.

Table 1. TIE Steering Committee* Name Unit John Reeve CBS Ken Lee Mo Saif

CFAES

Larry Schlesinger COM

Robert Brueggemeier CP Michael Lairmore William Saville

CVM

Tim Buckley Mary Ellen Wewers

SPH

*Only 1 voting member per unit

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Appendix A

Faculty Start-up, 49%

Faculty Recruitment, 3%

Graduate Education, 15%

Pilot Research, 21%

Program Coordinator, 12%

Once funded, the first step towards implementation will be to hire a coordinator to provide a key resource for implementation. Although the coordinator will be hired through SPH for practical reasons, the function of this position is to support the TIE program equally across the six colleges. The coordinator position will provide primary support to the Steering Committee in implementing the TIE by coordinating and recording meetings, assisting in the preparation of annual progress and fiscal reports, and facilitating TIE initiatives including faculty recruitment, graduate, and pilot research awards. We expect the coordinator to be hired by February 1, 2007. The most important feature of the TIE implementation will be faculty recruitment to fill critical TIE-related research needs. The importance of new faculty hires within the TIE is reflected by the allocation of 100% of the PBA and 52% of cash (Figure 1) toward this priority. These new hires have been identified to meet strategic needs in filling key gaps in expertise on this campus and complementing existing strengths. A total of twelve faculty positions are identified, however, we plan to fill five high priority positions in Phase 1, years 1 and 2 of the program (Table 2). Plans for the recruitment of the remaining eight positions will be developed by the Steering Committee over the course of 2006-07.

Table 2. TIE Faculty Hires

The educational mission of the TIE will be developed primarily through a competitive graduate research assistance program where tuition and stipend will be provided to outstanding doctoral applicants with an interest in TIE-related research. This program will be developed during the winter and spring of 2007 for implementation in the fall of 2007. A selection committee will be formed. Priority consideration will be given to applicants with interdisciplinary research interests. TIE resources allocated to this program represent 15 percent of the total cash award available.

Position Primary Appointment

Phase 1 Faculty Recruitment Translational (F1) COM Epidemiology (F7) SPH Mucosal Immunity (F11) CFAES Food Virologist (F12) CFAES Public Health Specialist (F8) CVM Out-Year Recruitment Vaccine (F2) CVM Experimental Therapeutics (F3) COM Transmission – Zoonoses (F5) CVM Surveillance (F6) SPH Veterinary Epidemiologist (F9) CVM Clinical Trials (F13) COM Cross Species – Zoonoses (F4) CVM

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To facilitate interdisciplinary TIE research across the colleges, a pilot research program will be initiated in the fall of 2007. As with the graduate education, this program will be developed during the winter and spring of 2007 and a selection committee will be formed for implementation in the fall of 2007. This pilot research program represents 21 percent of the TIE cash allocation. The program leaders have met with media and scientific staff members to coordinate the public relations and media distribution of key outcomes from the TIE, as well as provide a list of available experts to serve as resources for the University and citizens of the State of Ohio. In summary, the success of this TIE will be ensured through an implementation plan that has been developed and will be overseen by an existing steering committee with leadership representing each of the six colleges participating in the TIE. The TIE mission of promoting interdisciplinary research and education related to public health preparedness and infectious diseases will be achieved through a multifaceted implementation plan that includes strategically filling faculty positions in key research areas, and the development of interdisciplinary graduate research assistance and pilot research.

2009 Annual Report

A Collaborative initiative of the colleges of Biological Sciences; Food, Agricultural, and Environmental Sciences; Medicine; Pharmacy; Public Health; and Veterinary

Medicine

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2009 Annual Report

Appendix B

2008/2009 PHPID Program Summary Tables Tables 1 – 5

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Appendix B

Table 1 – 2008/2009 Faculty Recruitment Summary

#

FY of

Hire Focus CBS CFAES COM COP CPH CVM

Selection Committee

Chair 8-Apr-09

1 F8 FY07 Public Health Specialist 30% 70% NA HIRED - Armando Hoet

2 F1 FY08 Translational 30% 70% John Gunn HIRED - Dan Wozniak start Oct 1

3 F3 FY08 Experimental Therapeutics 70% 30%

Karl Werbovetz

HIRED - Mark Drew start September 1

4 F6 FY09 Surveillance 30% 70% Tim Buckley HIRED - Start 9/1 - Jiyoung Li

5 F7 FY08 Epidemiology 100% Kurt Stevenson

HIRED - Abigail Turner start October 1, 2009

6 F11 FY08 Mucosal Immunology 100% Jeff Le Juene HIRED - Gourapura Renukarahdya

7 F12 FY08 Food Virologist 70% 30% Ahmed Yousef HIRED - Jianrong Li

8 F9 FY09 Vet Epi 50% Tom Wittum HIRED - Rebecca Garabed - Starts Oct. 20

9 F4/F5 FY09

Cross Species/Transmission - Zoonoses 100% Patrick Green Candidate Xin Li

10 F2 FY09 Vaccine and Therapeutics 50%

Yasuko Rikhisa Candidate Li Wu

11 F13 FY10 Clinical Trials 70% 30% Not Appointed Advertisement in Development

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Appendix B

Table 2 – 2007 and 2008 Graduate Education Fellowship Awards

Program

PHPID Award Due per FY YR Total Award Project Title FY2008 PI FY2009 PI

Graduate Fellowship 1 33,900.00$ 67,800.00$ Gallbladder environment influences the carriage of Salmonella typhi Robert Crawford (COM) Robert Crawford (COM)

Graduate Fellowship 2 33,900.00$ 67,800.00$ Immune function in old age aiding the design of new vaccines and therapies for the elderly to combat respiratory infections Erin Rottinghaus (COM) Erin Rottinghaus (COM)

Graduate Fellowship 3 33,900.00$ 67,800.00$ Water quality and related safety of recreational waters throughout Ohio -- Jason Marion (CPH)

Graduate Fellowship 4 33,900.00$ 67,800.00$ Viral and host factors involved in the interspecies transmission of avian influenza -- Smitha Pillia (CFAES)

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Table 3 – 2008 PHPID Pilot Research Grant Awards

Program


Pilot Research Grant 1 50,000.00$ 100,000.00$ Public Health Preparedness for an Avian Influenza Pandemic: Virus Detection

and Inactivation Tim Buckley (CPH) Tim Buckley (CPH)

Pilot Research Grant 2 50,000.00$ 100,000.00$ The Influence of Environmental Change on Schistosomiasis Transmission in the Poyong Lake Region Song Liang (CPH) Song Liang (CPH)

Pilot Research Grant 3 50,000.00$ 100,000.00$ Development and Evaluation of Immersive Simulations for use in Response Training for Outbreaks of Infectious Diseases Mac Crawford (CPH) Mac Crawford (CPH)

Pilot Research Grant 4 (1/2 award) 25,000.00$ 50,000.00$

Zoonotic Methicillin Resistant Staphylococcus aureus (ZO-MRSA): A new headache? Armando Hoet (CVM) Armando Hoet (CVM)


Do Placental Viral Sequestration and Changes in Toll-Like Receptor Expression Promote HIV-1 Mother-To-Child Transmission in Malawi? Jesse Kwiek (COM) Jesse Kwiek (COM)

Pilot Research Grant 6 50,000.00$ 100,000.00$ Vesicular stomatitus Virus as the Vector to Deliver Human Norovirus virus-like Particles: a new vaccine strategy against non-cultivable foodborne viruses -- Jianrong Li (CFAES)

Pilot Research Grant 7 50,000.00$ 100,000.00$ Nucleotide Synthesis Inhibitors as Novel Therapies for Hypoxemia Induced by

Influenza Virus Infection -- Ian Davis (CVM)Pilot Research Grant 8 (1/2 award) 25,000.00$ 50,000.00$

Do Placental Viral Sequestration and Changes in Toll-Like Receptor Expression Promote HIV-1 Mother-To-Child Transmission in Malawi? -- Jesse Kwiek (COM)

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Appendix B

Table 4 – 2008 PHPID Program Funds Utilization Funds Utilization

Combined Program Year 1 (FY07) Year 3 (FY09) Calendar 2008/2009CF Cash CF Cash CF Cash Decription

Program FTE

F1 Translational (COM/CBS) 70% -$ -$ 109,455$ 105,051$ -$ 105,051$ Dan Wozniak, start-date: October 1, 2008

F2 Vaccine and Therapeutics (CVM) 50% -$ -$ -$ -$ 63,050$ 43,068$ Li Wu, current top faculty candidate in discussions with College

F3 Experimental Therapeutics (COM/COP) 100% -$ -$ -$ -$ 126,100$ 86,136$ Mark Drew, start-date: September 1, 2008

F4/F5 Zoonoses (CVM) 100% -$ -$ -$ -$ 63,050$ 43,068$ Combined F4/F5 position to create full FTE. Xan Li, current top candidate in discussions with College

F6 Surveillance CPH/CFAES) 100% -$ -$ -$ -$ 126,100$ 86,136$ Jiyoung Li, start-date: September 1, 2008F7 Epidemiology (COM) 100% -$ -$ 126,100$ 86,136$ -$ 86,136$ Abigail Turner, start-date: September 1, 2008F8 Public Health Specialist (CVM/CPH) 80% 100,880$ 68,908$ -$ 68,908$ -$ -$ Armando Hoet, start-date: October 1, 2007F9 Veterinary Epidemiologist (CVM) 50% -$ -$ -$ -$ 63,050$ 43,068$ Rebecca Garabed, start-date: October 20, 2008

F11 Pre-Harvest (CFAES/OARDC/FAHRP) 100% -$ -$ 126,100$ 86,136$ -$ 86,136$ Renukarahdya Gourapura, start-date: May 1, 2008F12 Post-Harvest (CFAES/CPH) 100% -$ -$ 126,100$ 86,136$ -$ 86,136$ Jianrong Li, start-date: July 1, 2008

F13 Clinical Trials (Associate Professor, MD) 100% -$ -$ -$ -$ -$ -$ Search Committee being formed. Search will begin in fall of 2009

S1 TIE Program Coordinator 100% -$ 39,030$ -$ 80,402$ -$ 82,814$

Eric Lutz, start-date: May 1, 2007. Carry-over funds used for membership meetings, website, communications

Program supplies and services -$ 5,500$ -$ 7,000$ -$ 7,000$ Program management supplies and services

T1 Graduate Education -$ -$ -$ 67,800$ -$ 139,668$

$68,350 for two 2008 awards: Jason Marion and Smitha Pillia. $68,350 for year two of 2007 awards: Robert Crawford and Erin Rottinghaus.

R1 Pilot Seed Grants -$ -$ -$ 100,000$ -$ 200,000$

$100,000 for 2008 awardees, Jianrong Li and Ian Davis. $100,000 for year two of 2007 awardees Tim Buckley, Mac Crawford. $100,000 in program salary savings used for year two awards for 2007 awardees Song Liang, and Jesse Kwiek.

Total 100,880$ 113,438$ 487,755$ 687,568$ 441,350$ 1,094,414$ Total Faculty FTE Supported 9.5

College

Original Amount

Requested

Adjusted Amount of Transfer

Additional Allocation (to

cover difference)

Funding Source Not

Yet Captured DescriptionBioSci 78,316.00$ 36,560.00$ FAES 255,657.75$ 171,892.67$ Med 197,192.51$ Pharm 33,560.00$

Pub Health 248,571.95$ 94,575.00$ Salary Savings from Epi Position 70%CPH / 30%COM (Jul08-Mar09)*Vet 67,396.00$ 47,287.50$ Salary Savings from Cross-Species Zoonoses Position (Jul08-Mar09)*

Total 880,694.21$ 755,173.13$ 125,521.08$ 141,862.50$

GRAND TOTAL 755,173.13$ * Recruitment expenses have not been deducted.

Transfer # FY09 Programatic Funds Utilization Chartfields

1 - 2nd yr 2008 Pilot Grants 200,000.00$ 50,000.00$ Crawford 25050-013100-60000-16230-CRAW(50,000+50,000+50,000+25,000+25,000) 50,000.00$ Buckley 25050-013100-60000-16230-BUCKLY

50,000.00$ Liang 25050-013100-60000-16230-LIANG25,000.00$ Hoet 29760-013100-60000-16230-RESRCH25,000.00$ Kwiek 25258-013100-60000-16230-JKPRG

2 - 1st yr 2009 Pilot Grants 125,000.00$ 50,000.00$ Li 11561-013100-60000-prj# 11-LI-16230(50,000+50,000+25,000) 50,000.00$ Davis 29400-013100-60000-16230-DAVIS

25,000.00$ Kwiek 25258-013100-60000-16230-JKPRG

FY09 Budgeted Allocation

Year 2 (FY08)

FY09 Programmatic Funds Distribution and Salary Savings Capture

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Appendix B

Table 5 – 2008 PHPID Program Expenditures for fellowships, grants, and collaborative programs

Program


Pilot Research Grant 1 50,000.00$ 100,000.00$ Public Health Preparedness for an Avian Influenza Pandemic: Virus Detection

and Inactivation Tim Buckley (CPH) Tim Buckley (CPH)

Pilot Research Grant 2 50,000.00$ 100,000.00$ The Influence of Environmental Change on Schistosomiasis Transmission in the

Poyong Lake Region Song Liang (CPH) Song Liang (CPH)

Pilot Research Grant 3 50,000.00$ 100,000.00$ Development and Evaluation of Immersive Simulations for use in Response

Training for Outbreaks of Infectious Diseases Mac Crawford (CPH) Mac Crawford (CPH)Pilot Research Grant 4 (1/2 award) 25,000.00$ 50,000.00$

Zoonotic Methicillin Resistant Staphylococcus aureus (ZO-MRSA): A new headache? Armando Hoet (CVM) Armando Hoet (CVM)


Do Placental Viral Sequestration and Changes in Toll-Like Receptor Expression Promote HIV-1 Mother-To-Child Transmission in Malawi? Jesse Kwiek (COM) Jesse Kwiek (COM)

Pilot Research Grant 6 50,000.00$ 100,000.00$ Vesicular stomatitus Virus as the Vector to Deliver Human Norovirus virus-like Particles: a new vaccine strategy against non-cultivable foodborne viruses -- Jianrong Li (CFAES)

Pilot Research Grant 7 50,000.00$ 100,000.00$ Nucleotide Synthesis Inhibitors as Novel Therapies for Hypoxemia Induced by

Influenza Virus Infection -- Ian Davis (CVM)Pilot Research Grant 8 (1/2 award) 25,000.00$ 50,000.00$

Do Placental Viral Sequestration and Changes in Toll-Like Receptor Expression Promote HIV-1 Mother-To-Child Transmission in Malawi? -- Jesse Kwiek (COM)

Pilot Research Grant 9 50,000.00$ 100,000.00$ -- --Pilot Research Grant 10 50,000.00$ 100,000.00$ -- --Pilot Research Grant 11 50,000.00$ 100,000.00$ -- --Pilot Research Grant 12 50,000.00$ 100,000.00$ -- --Graduate Fellowship 1 33,900.00$ 67,800.00$ Gallbladder environment influences the carriage of Salmonella typhi Robert Crawford (COM) Robert Crawford (COM)

Graduate Fellowship 2 33,900.00$ 67,800.00$ Immune function in old age aiding the design of new vaccines and therapies for the elderly to combat respiratory infections Erin Rottinghaus (COM) Erin Rottinghaus (COM)

Graduate Fellowship 3 33,900.00$ 67,800.00$ Water quality and related safety of recreational waters throughout Ohio -- Jason Marion (CPH)

Graduate Fellowship 4 33,900.00$ 67,800.00$ Viral and host factors involved in the interspecies transmission of avian influenza -- Smitha Pillia (CFAES)

Graduate Fellowship 5 33,900.00$ 67,800.00$ -- --Graduate Fellowship 6 33,900.00$ 67,800.00$ -- --Graduate Fellowship 7 33,900.00$ 67,800.00$ -- --Graduate Fellowship 8 33,900.00$ 67,800.00$ -- --

CWC/PHPID Pilot Grant 1 25,000.00$ 50,000.00$ The Global Impact of Terrestrial Surface Waters on the Distribution of Water-

Related Infectious Diseases -- Song Liang (CPH)

CWC/PHPID Pilot Grant 2 25,000.00$ 50,000.00$ Engaging the Public Health System in Reducing the Societal Carbon Footprint -- Mac Crawford (CPH)CCTS/PHPID Pilot Grant 1 25,000.00$ 50,000.00$ Methyltransferase-Defective Recombinant Viruses as Live Vaccine Candidates -- Jianrong Li (CFAES)CCTS/PHPID Pilot Grant 12,500.00$ 25,000.00$ Novel rapid detection of P. aeruginosa from liquid and aerosol samples in clinical -- Jiyoung Lee (CPH)CCTS/PHPID Pilot Grant 3a 12,500.00$ 25,000.00$

Efficiency of Ware Washing Protocols for Removal of Foodborne Viruses from Utensils in Restaurants and Food Service Establishments -- Melvin Pascall (CFAES)

2009 Annual Report

Appendix C

Curriculum Vitae

Eric Lutz, PHPID Program Manager Armando Hoet, Colleges of Public Health and Veterinary Medicine Jianrong Li, Colleges of Food, Agricultural, and Environmental Sciences and Public Health Renukarahdya Gourapura, College of Food, Agricultural, and Environmental Sciences, OARDC, FAHRP Jiyoung Li, Colleges of Public Health and Food, Agricultural, and Environmental Sciences Daniel Wozniak, Colleges of Medicine and Biological Sciences, Division of Microbiology Mark Drew, Colleges of Medicine and Pharmacy Rebecca Garabed, College of Veterinary Medicine

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Appendix C

ERIC ANTHONY LUTZ CURRICULUM VITAE

CONTACT INFORMATION

Home Address Business Address 2177 Gromwell Drive The Ohio State University Columbus, Ohio 43221 264D Howlett Hall Phone: 740-398-1638 2001 Fyffe Court email: [email protected] Columbus, Ohio 43210 Phone: 614-292-2590 email: [email protected]

EDUCATION B.A. 1996 The Ohio State University Chemistry College of Arts and Sciences Columbus, Ohio M.P.H. 2005-2007 Johns Hopkins University Public Health Bloomberg School of Public Health Baltimore, MD (Transferred to OSU PhD program prior to completion) M.S. 2009 The Ohio State University Env. Health Science College of Public Health Columbus, Ohio Ph.D. Post-candidacy The Ohio State University Env. Health Science College of Public Health Columbus, Ohio (Graduation – 12/09)

PROFESSIONAL CERTIFICATIONS Instructor of Chemistry and Environmental Technologies 1998 Maricopa Co. Comm. College, AZ Certified Indoor Air Quality Consultant (CIAQC) 1999-2007 American IAQ Association



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Certified AHERA Inspector/Management Planner 2000-2007 USEPA Certified Teacher, Sciences 2001 Arizona State Board of Education Certified Infrared Thermographer 2005 Building Science Institute Certified Water Damage Restoration 2006 IICRC Six Sigma - Green Belt - Process Dynamics, Statistical Evaluation, and Optimization 2007 Tyco Electronics QA/QC

DISSERTATION RESEARCH “Airborne Transmission and Indoor Environmental Surveillance of Methicillin-Resistance Staphylococcus aureus in a Veterinary Hospital” Under the direction of: Timothy Buckley, PhD, CIH - College of Public Health (advisor) Armando Hoet, DVM, PhD – College of Vet. Medicine/College of Public Health Jeff LeJeune, DVM, PhD – College of Food, Ag., and Env. Sciences/OARDC Song Liang, PhD – College of Public Health Thomas Wittum, PhD – College of Veterinary Medicine In consultation with: Kurt Stevenson, MD, MPH – College of Medicine/College of Public Health

GLOBAL PUBLIC HEALTH ACTIVITIES China Epidemiological Multi-Village Questionnaire 2008 S. japonicum surveillance Ecological Survey, Poyong Lake Region Oncomanelia snail habitat Proof-of-Concept Field Evaluations S. japonicum cercariae sampling device

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PROFESSIONAL POSITIONS Program Manager 2007 - present The Ohio State University, Columbus, OH • Oversee all administrative aspects of the $4.7 MM Targeted Investment in Excellence program

in Public Health Preparedness for Infectious Diseases (PHPID), including:

• Managing all six participating-college’s program activities.

• Generation of public reports that includes the 125 PHPID-faculty members research achievements and milestones, PHPID membership recruitment, academic achievements gained by PHPID Graduate Student Fellows, and descriptions of inter- and intra-institutional programmatic collaborations.

• Coordination and participation with governing Steering Committee and all sub-committees.

• Coordinate and oversee cross-college faculty recruitments funded by the program.

• Management of all programmatic graduate fellowships and faculty pilot research grant searches, awards, and distributions.

• Management of communications efforts, including web-site design and content management.

• Programmatic fiscal oversight of $4.7 MM budget.

• Promotion and expansion of cross-college research collaborations.

• Creation and facilitation of novel interdisciplinary research programs and grants at the local and federal levels.

• Additional information can be found at www.phpid.osu.edu.

Senior EHS Coordinator/Facilities Manager 2006-2007 Tyco Electronics, Aerospace and Defense Division, Mansfield, OH • Serve as director for all aspects of EHS at Hartman. Concurrently serve as manager for all

maintenance, capital projects, and non-production acquisitions.

• Concurrent to above, selected for special duty managing and optimizing the two most technically-complex production lines and subsequently, daily first-shift machining and fabrication activities.

Regional Manager 2005-2006 Anderson Group International, Bakersfield, CA • Managed daily operations of eastern region, including business development, project

management oversight, and emergency response logistics.


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• Directed all environmental, health, and safety consulting and disaster response projects nationally.

• Served as the corporate EHS manager.

National Program Manager 2000-2005 Environmental Management Group, Inc., Phoenix, AZ • Entrepreneurial Venture - Directed industrial hygiene, indoor environmental consulting,

environmental health, safety consulting, and litigation support/expert witness services from five offices serving healthcare, education, insurance, and corporate clients throughout the United States.

• Invited to provide environmental health and safety training and seminars throughout the country.

Director of Western Operations 1997-2000 BioGard Environmental Services, Inc., Phoenix, AZ • Opened and grew western office to serve seven western states, providing indoor environmental

consulting, testing, treating, safety, and remediation services.

• Environmental remediation and safety training provided to clients and seminar attendees throughout the western states.

Project Chemist 1994-2000 Sharp and Associates, Inc., Columbus, OH/Phoenix, AZ Environmental Researcher 1990-1994 Battelle Memorial Institute, Columbus, OH

MILITARY SERVICE Builder/Safety Petty Officer 1989-1996 United States Navy, Gulfport, MS Reserve Naval Mobile Construction Battalion 20 United States Navy Reserves, Rickenbacker, Columbus, OH United States Navy Reserves, Defense Construction Supply Center, Columbus, OH

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ACADEMIC POSITIONS

Adjunct Professor, Chemistry and Environmental Technologies 1998-2002 Maricopa County Community Colleges, Phoenix, AZ OSHA and DOT Trainer 1997-2003 Maricopa County Community Colleges, Phoenix, AZ

GRANTS, FUNDING, AWARDS Business and Industry Grant – Halo Company 2008 Principal Investigator – T. Buckley, Ph.D. $16,279.00 Preparing Future Faculty Fellow 2008-2009 NSF/OSU - Research Institution/Liberal Arts University Mentoring Fellowship Mentor –Chris Gillen, Ph.D., Department of Environmental Science/Biology Kenyon College, Gambier, OH

COURSES DEVELOPED Fundamentals of Industrial Hygiene, 700-level 2009 OSU, College of Public Health Division of Environmental Health Sciences Collaborators – Timothy Buckley, PhD and Jonathan Lutz, MPH International Public Health in Developing Countries, 800-level 2008 OSU, College of Public Health Environmental Health Sciences Section Collaborators - Song Liang, PhD and Chris Rea

COURSES TAUGHT - ADJUNCT PROFESSOR, LEAD INSTRUCTOR Laboratory Chemistry – 101, n = 24 2001- 2002

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Entry-level Chemistry Lab Laboratory Chemistry – 102, n = 20 2001- 2002 Mid-level Chemistry Lab Environmental Technologies – Level I, n=30 1998- 2002 Environmental Health Toxicology Environmental Technologies – Level II, n=35 1998- 2002 Environmental Science Risk Assessment Environmental Technologies – Level III, n=25 1998- 2002 Regulatory Agencies Emergency Response OSHA Hazardous Waste Operators Certification Course 1997- 2003 Hazard Waste Operators Training - 40 hour, n=45 OSHA Hazardous Waste Operators Certification Course 1997- 2003 Hazard Waste Operators Training - 8 hour Refresher, n=45 DOT Hazardous Materials Transport 1997- 2003 Hazard Materials Training - 24 hour, n=35

COURSE LECTURES Field Epidemiology – 794 2009 The Ohio State University, n = 8, 90 minutes 1. Problem Solving in Public Health 2. Infectious Diseases 3. S. japonicum field study

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Current Topics in Environmental Health – 530 2009 The Ohio State University, n=35, 120 minutes 1. Toxic Metals 2. Organic Chemicals Biology 243: Comparative Animal Physiology 2008 Kenyon College, n = 30, 75 minutes 1. Schistosoma japonicum in China: Epidemiology, Life Cycle, and Disease Mechanisms in

Mammals Field Epidemiology – 794 2008 The Ohio State University, n = 8, 90 minutes 1. Public Health Preparedness 2. Infectious Diseases Current Topics in Environmental Health – 530 2008 The Ohio State University, n=29, 120 minutes 1. Toxic Metals 2. Organic Chemicals

CONFERENCE, SEMINARS, AND PRESENTATIONS Ceftiofur Resistance in Swine Operations June 20-22, 2009 Airborne Shedding Characteristics of NDV, as a Surrogate

for Avian Influenza, in Poultry Operations Interdisciplinary Conference on Food, Environment, and Public Health Xi’an Jiaotong University College of Medicine/The Ohio State University Xi’an City, Shaanxi Province, China Evaluation of a UVC-Equipped Vacuum at Reducing June 4, 2009 Total Surface-Bound Microbial Load on Carpets AIHce09 Toronto, BC, Canada Domestic/Intl Service, Public Health Practice for Scientists, n=25 2008 University of Dayton Departments of Premedical Programs and Biology Dayton, Ohio Roundtable Discussion – Public Health Ed./Practice, n=20 2008

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Kenyon College Department of Biology Gambier, Ohio Domestic/Intl Service, Public Health Practice for Scientists, n=30 2008 Kenyon College Department of Biology Gambier, Ohio Mold Infestation Claims - Training Seminars, n=250 2003 American Society of Professional Education Sacramento, CA; San Francisco, CA; Los Angeles, CA; Phoenix, AZ; Kansas City, MO; Cleveland, OH; Columbus; OH Indoor Air Quality in Residential Environments, n=350 2002 Home Builders Conference Las Vegas, NV Home Builders Responsibility – Indoor Air Quality, n=300 2001 Home Builders Conference Las Vegas, NV Mold in Homes - Radio Broadcast, IAQ Expert 2001 National Airing of Panel Discussion United States of America Avoid Litigation from Mold in Homes, n=300 2000 Customer Service - Home Builders Conference Las Vegas, NV Mold Contamination in Homes, n=200 1999 Customer Service - Home Builders Conference Las Vegas, NV

POSTERS, MANUSCRIPTS, AND PEER REVIEWED ARTICLES 1. Lutz, E., Wittum, T., Gebreyes, W. Antimicrobial Resistance of Escherichia coli to Third-Generation Cephalosporins isolated from Swine Herds. Manuscript in preparation. January, 2009.

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2. Sharma, S., Lutz, E., Needham, G., Buckley, T. Effectiveness of UV-equipped commercial vacuum in reducing carpet surface microbes. The Ohio State University, College of Public Health, Poster Exposition. November, 2008. 3. Eric A. Lutz; Smita Sharma, Bruce Casto, Glen R. Needham, Timothy J. Buckley. Evaluation of UV-C Equipped Vacuum at Reducing Culturable Surface-bound Microorganisms on In-home Carpets. Manuscript in preparation. October, 2008. 4. Sharma, S., Lutz, E., Needham, G., Buckley, T. Effectiveness of UV-equipped commercial vacuum in reducing carpet surface microbes. Ohio Asthma Coalition Conference, Research Poster Competition. August, 2008. 5. Timothy J. Buckley, Laura A. Geer, Thomas H. Connor, Mark Boeniger, and Eric A. Lutz. Evaluation of a Multifactor Assessment Methodology for Workplace Dermal Exposures to Cypermethrin at a Chemical Manufacturing Plant. Manuscript in preparation. August, 2008.

CURRENT SERVICE, MEMBERSHIPS, AND AFFILIATIONS Rep OSU Graduate School, Task Force on Life Sciences 2009- current Rep Global Health Specialization Subcommittee, EHS Student Rep. 2008- current Rep Society of Public Health Students, Diversity Rep. 2008- current Rep Graduate Studies Committee, CPH PhD Student Rep. 2008- current Rep College of Public Health Diversity Committee 2007- current Member International Society of Exposure Science 2008- current Member American Industrial Hygiene Association 2008- current Member Am. Conference of Governmental Industrial Hygienists 2008- current

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Curriculum Vitae Armando Eduardo Hoet Siberio, DVM, PhD

Department of Veterinary Preventive Medicine, College of Veterinary Medicine The Ohio State University. Columbus, Ohio 43210-1092

Telephone: 614 - 292 - 0684, Fax: 614 - 292 - 4142, E-mail: [email protected] Updated April 2007 1. PERSONAL INFORMATION Birthday: February 11, 1967. Place of birth: Maracaibo, Zulia State, Venezuela. Civil status: Married (two children). 2. CURRENT APPOINTMENT • Clinical Assistant Professor. Veterinary Public Health Specialization, Department of Veterinary Preventive

Medicine, College of Veterinary Medicine, The Ohio State University. January 10, 2005 to present. (0.65 FTE Didactic Education Veterinary Public Health program; 0.05 FTE Administration; 0.3 FTE Scholarship and Research).

• Coordinator of the Veterinary Public Health specialization towards the Master of Public Health degree at the

School of Public Health. Department of Veterinary Preventive Medicine, The Ohio State University. January 10, 2005 to Present.

• Adjunct Clinical Assistant Professor. Division of Epidemiology, School of Public Health, The Ohio State

University (non-salaried). April 2006 to present. • Member of the Graduate Student Committee of the Veterinary Preventive Medicine Department, The Ohio

State University. March 2006 to Present. 3. ACADEMIC CREDENTIALS • Doctor of Philosophy. The Ohio State University. Dissertation: Bovine Toroviruses (Breda virus): Development

of diagnostic tests and epidemiology. GPA: 3.88. Advisor: Dr. Linda J Saif. Summer 2002. • Specialization in Large Animal Practice. Intern of the Large Animal Section, University Veterinary Clinic

(Policlínica Veterinaria Universitaria), College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. 1992-1993.

• Doctor of Veterinary Medicine. College of Veterinary Sciences (Facultad de Ciencias Veterinarias), The

University of Zulia (La Universidad del Zulia). Maracaibo, Venezuela. 4th/33. 1991.

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4. OTHER TRAINING • Weapons of Mass destruction - Agricultural Emergency Response Training. US Department of Homeland

Security, Center for Domestic Preparedness and Auburn University. Anniston, Alabama, USA. June 10, 2005. 24 hours.

• Introduction to HACCP principles. The Ohio State University Meat Extension under the auspices of the Ohio

Department of Agriculture. Reynoldsburg, Ohio, USA. May 3-4, 2005. 16 hours. • Vesicular Diseases (Enfermedades Vesiculares). Ministry of Agriculture, Republic of Venezuela. La Villa del

Rosario, Venezuela. December 1995. 12 hours. • Training in Diagnostic Techniques for General Virology, Vesicular Diseases, and Rabies (Técnicas de

Diagnóstico en Virología General, Enfermedades Vesiculares y Rabia). National Center for Agriculture Investigation (Centro Nacional de Investigaciones Agropecuarias). Maracay, Aragua, Venezuela. July 1994. 240 hours.

• Series of Courses titled Teaching Improving and Updating on Higher Education (Actualización y

Perfeccionamiento Docente en Educación Superior). Division for Graduate Studies, College of Humanities, University of Zulia. Maracaibo, Venezuela. This course is composed by two sections, the first one with four workshops and the second section with two workshops: - Workshop 1. “Didactics Center in Processes” (Didáctica Central en Procesos). July 1993. 30 hours. - Workshop 2. “Instructional Design” (Diseño Instruccional). June 1993. 30 hours. - Workshop 3. “Evaluating Learning” (Evaluación de los Aprendizajes). From September 1993. 30 hours. - Workshop 4. “Strategies and Instructional Media” (Estrategias y Medios Instruccionales). December

1993. 30 hours. - Workshop 5. “Planning Higher Education” (Planificación de la Educación Superior). July 1994. 30 hours. - Workshop 6. “Introduction to Education Management” (Introducción a la Gerencia Educativa). July

1994.

• Diagnosis and Control of Bovine Mastitis (Diagnóstico y Control de Mastitis Bovina). Coordination of Graduate Studies from the School of Veterinary Sciences, the Central-Occident University “Lisandro Alvarado” (UCLA). Barquisimeto, Lara, Venezuela. June 1993. 40 hours.

• Economy of the milk production (Economía de la Producción Lechera). Division of Graduate Studies, College

of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. June 1993. 16 hours. • Training course Judge and Classifier of Dairy Cattle (Clasificadores y Jueces de Ganado Lechero). Ministry

of Agriculture and the Venezuelan Society of Specialists in Classifying and Judging Dairy Cattle. Mérida, Mérida, Venezuela. November 1991. 80 hours.

• Diagnostic Techniques for Bovine Brucellosis (Técnicas de Diagnóstico en Brucelosis Bovina). Division of

Graduate Studies, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. April 1991. 40 hours.

• Basic Aspects on Biochemistry and Immunology of Hemoparasites of Veterinary Interest (Aspectos

Básicos de Bioquímica e Inmunología de Hemoparasitos de Interés Veterinario). Division of Biological Sciences, Simon Bolivar University (Universidad Simon Bolivar). Caracas, Venezuela. March 1991. 40 hours.

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5. SPECIAL ACADEMIC HONORS AND AWARDS • Selected as Researcher Level II by the Venezuelan Government in the Program for the Promotion of

Researchers (Programa de Promoción al Investigador, PPI). Program sponsor by the Venezuelan Presidential Office and the Ministry for Science and Technology through the Venezuelan Foundation for Researchers Promotion. It includes a diploma and cash monthly stipend for three years. Award entrusts through a national selection process every three years to highly qualified active researchers. November 2004 to present.

• “The Best Professor 2003”. College of Veterinary Sciences, The University of Zulia. Award granted by the

students of the College of Veterinary Sciences, presented once a year during the Anniversary Week of the College. May 2004.

• Acknowledgment for “10 years of uninterrupted teaching and research labor” at College of Veterinary

Sciences, The University of Zulia. May 2003. • Selected as Researcher Level I by the Venezuelan Government in the Program for the Promotion of

Researchers (PPI) (Diploma and cash). December 2002 to November 2004. • Acknowledgment by the Veterinarian Association of Zulia State, for Scientific and Academic Achievements.

Maracaibo, Venezuela. September 2002. • Winner of the American College of Veterinary Microbiologists Award, Virology Section, presented at the

Conference of Research Workers in Animal Diseases (CRWAD). St. Louis, Missouri. November 15, 2001. • Winner of the Comparative Gastroenterology Society Young Investigator Abstract Award, presented at the

Conference of Research Workers in Animal Diseases (CRWAD). Chicago, Illinois. November 14, 2000. • The Delta Chapter of Phi Zeta National Veterinary Honor Society. Columbus, Ohio. May 2000. • Selected as Researcher in the Candidate level by the Venezuelan Government in the Program for the

Promotion of Researchers (PPI) # 4427 (Diploma and cash). March 2000 to March 2002. • The National Honor Society of Phi Kappa Phi, The Ohio State University Chapter. Columbus, Ohio. May

1999. • “Professor Homage” of the XLI Veterinarian Graduating Class “50 years of LUZ reopening” (50 Años de la

Reapertura de LUZ). College of Veterinary Sciences, The University of Zulia. Each graduating class of Doctors in Veterinary Medicine choose 2 to 3 professors to honor them in the commitment ceremony, publicly recognizing their academic and professional trajectory with a commemorative dedicated plaque. October 1996.

• “The Best Professor 1995-1996” in the College of Veterinary Sciences, The University of Zulia. College of

Veterinary Sciences, The University of Zulia. Award granted by the students of the College of Veterinary Sciences, presented once a year during the Anniversary Week of the College. May 1996.

• Recognition as “Professor in Extension Activities” in 1995-1996 at College of Veterinary Sciences. College

of Veterinary Sciences, The University of Zulia. May 1996.

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• Five consecutive “Honor Roll”. The University authorities give this annual award to the top 10 students with the best academic record at the Veterinary College. The University of Zulia. November 1987, 1988, 1989, 1990, and 1991.

• Eight Honor’s Diplomas in different courses during the Veterinary Career (8/40 courses). The University of

Zulia gives these diplomas to the students that obtain the maximum grades (A+ or 19-20 grade pts of 20) in a specific course. They were:

- Professional Practice in Animal Health (Prácticas Profesionales en Sanidad Animal), 1990. - Programmed Animal Reproduction (Reproducción Animal Programada), 1990. - History and Deontology (Historia y Deontología), 1990. - Aviculture (Avicultura), 1990. - Clinic Pathology (Patología Clínica), 1990. - Dairy Science and Technology (Ciencia y Tecnología de la Leche), 1989. - Farm Administration (Administración de Fincas), 1989. - Veterinary Anatomy Pathology (Anatomía Patológica Veterinaria), 1987.

• Several letters of recognition from different authorities and superiors, such as the president of the University of

Zulia.

6. ACADEMIC AND PROFESSIONAL EXPERIENCE • Aggregate Professor of Infectious Diseases. Transmissible Diseases Department, College of Veterinary Sciences,

The University of Zulia. Maracaibo, Venezuela. February 1995 to December 2004. • Technical Advisor of Fort Dodge ® Venezuela. September 2003 to December 2004. • Guest Professor for Graduate Program of the College of Veterinary Sciences. Universidad Central de Venezuela

(Venezuelan Central University). Maracay, Venezuela. July 2003 to December 2004. • Guest Professor for the Division of Graduate Studies. College of Veterinary Sciences, The University of Zulia.

Maracaibo, Venezuela. February 2003 to December 2004. • Graduate Research Associate. Food Animal Health Research Program, Ohio Agricultural Research and

Development Center, The Ohio State University. June 1999 to July 2002. • Fellowship Professor (Becaría Docente). Infectious Disease Course, Department of Transmissible Diseases,

College of Veterinary Sciences, The University of Zulia. February 1993 to February 1995. • Intern of the Large Animal section. University Veterinary Clinic, College of Veterinary Sciences, The

University of Zulia. Maracaibo, Venezuela. February 1992 to February 1993. • Teacher’s Assistant in the course “Ecology and Physiology of Animal Production”. College of Veterinary

Sciences, The University of Zulia. February 1990 to February 1991. • Teacher’s assistant Ad Honorem in the course “Animal Physiology”. College of Veterinary Sciences, The

University of Zulia. January 1987 to December 1988.

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7. ACADEMIC AND PROFESSIONAL POSITIONS AND RESPOSABILITIES • Member of the Graduate Student Committee of the College of Public Health, The Ohio State University.

January 2006 to Present. • Member of the College of Veterinary Sciences Council as a Professor Representative (first substitute).

College of Veterinary Sciences, The University of Zulia. October 2004 to December 2004. • Member of the Committee for Promotion. College of Veterinary Sciences, The University of Zulia. February

2004 to December 2004. • Head of the Infectious Diseases Course. College of Veterinary Sciences, The University of Zulia. January

2004 to December 2004. • Head of the Diagnostic Lab for Infectious Diseases. College of Veterinary Sciences, The University of Zulia.

April 2003 to December 2004. • College of Veterinary Sciences Delegate to the Council for the Scientific and Humanistic Development of the

University of Zulia. College of Veterinary Sciences, The University of Zulia. October 2003 to October 2004. • Interim Head of the Infectious Diseases Course. College of Veterinary Sciences, The University of Zulia.

April 2003 to January 2004. • Coordinator for Continuing Education. Extension Division, College of Veterinary Sciences, The University

of Zulia. April 2003 to September 2003. • Team Leader of Laboratory Lectures of the Infectious Diseases Course. College of Veterinary Sciences, The

University of Zulia. September 2002 to April 2003. • Graduate Student Representative for the Graduate Student Association of the Department of Veterinary

Preventive Medicine at The Ohio State University. September 2000 to September 2002. • Member of College of Veterinary Sciences Council as a Professor Representative. College of Veterinary

Sciences, The University of Zulia. October 1996 to April de 1997. • Team Leader of Laboratory Lectures of the Infectious Diseases Course. College of Veterinary Sciences, The

University of Zulia. March 1995 to April 1997. • Coordinator for Continuing Education. Extension Division, College of Veterinary Sciences, The University

of Zulia. April 1995 to April 1997. • Advisor of the Veterinary Student Research Center (Centro de Investigación Estudiantil de Veterinaria,

CIEV). College of Veterinary Sciences, The University of Zulia. April 1995 to present. • Coordinator of the First Auction of Dual-Purpose Cattle. College of Veterinary Sciences, The University of

Zulia. November 1995. • Director of the Veterinary Student Research Center (CIEV). College of Veterinary Sciences, The University

of Zulia. January 1991 to December 1991.

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• Founder Subdirector of the Veterinary Student Research Center (CIEV). College of Veterinary Sciences, The University of Zulia. May 1990 to December 1990.

8. PUBLICATIONS AND SCHOLARLY CONTRIBUTIONS

- BOOKS • Coeditor of the peer-reviewed book titled “Manual for Dual Purpose Cattle” (Manual de Ganadería Doble

Propósito). González-Stagnaro C.; and Soto-Belloso E. (Eds). Ediciones Astro Data, S.A. ISBN 980-6863-00-3. Maracaibo-Venezuela. Pages 1-704. 2005.

- BOOK CHAPTERS

I. Hoet AE*, Saif L. Chapter 27: “Torovirus Pathogenesis and Immune Responses”. In: The Nidoviruses. Perlman S, Gallagher T, Snijder E. (Eds). ASM Press. In Press 2007.

II. Hoet, AE. Herd Biosecurity (Bioseguridad para el Rebaño). In: Manual for Dual Purpose Cattle (Manual de

Ganadería de Doble Propósito). González-Stagnaro C.; and Soto-Belloso E. (Eds). Maracaibo-Venezuela. V (1):283-290. 2005.

III. Hoet, AE. Designing a Biosecurity Program (Diseño de un Programa de Bioseguridad). In: Manual for Dual

Purpose Cattle. González-Stagnaro C.; and Soto-Belloso E. (Eds). Maracaibo-Venezuela. V (2):291-294. 2005.

IV. Hoet, AE*, Boscan L. Bovine Diarrheic Complex (Complejo Diarreico del Bovino). In: Manual for Dual Purpose Cattle. González-Stagnaro C.; and Soto-Belloso E. (Eds). Maracaibo-Venezuela. V (11):340-347. 2005.

V. Hoet, A. Economic Repercussions of Abortions Caused by Brucella and Leptospires (Repercusión

económica de los abortos causados por Brucelas y Leptospiras). In: Management of Dual-Purpose Mixed Breed Cattle (Manejo de la Ganadería Mestiza de Doble Propósito). Madrid-Bury, N. and Soto Belloso, E. (Eds). 2nd Edition. Maracaibo-Venezuela. III(X):154-175. 1995.

- PEER REVIEWED JOURNAL ARTICLES

I. Morgan JA, Hoet AE, Wittum TE, Monahan , Martin JA. Reduction of coliforms in dairy wastewater using

an ecological treatment system. Journal of Environmental Quality. Resubmitted Feb 2007.

II. Boscán-Duque LA, Arzálluz-Fischer AM, Ugarte C, Sánchez D, Wittum TE, Hoet AE. Reduce Susceptibility to Quinolones among Salmonella Isolated from Slaughter Poultry in Venezuela. Journal of Food Protection. Accepted for publication.

III. Briceño-Torres L, Narváez-Bravo CA, Rodas-González A, Wittum TE, Hoet AE. Fluoroquinolone

resistance in Salmonella spp. strains isolated in whole chicken processing (Resistencia a las fluoroquinolonas de cepas de Salmonella spp aisladas en el procesamiento de pollo entero). Accepted for Publication.

IV. Narváez-Bravo CA, Carruyo-Núñez G, Moreno M, Rodas-González A, Hoet AE, Wittum TE. Isolation of E.

coli O157:H7 from feces in dual purpose cattle. Revista Científica (ISSN 0798-2259). Accepted for Publication.

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V. Thomas CJ, Hoet AE, Sreevatsan S, Wittum TE, Briggs R, Duff GC, Saif LJ. Transmission of Bovine Coronavirus and serologic responses in feedlot calves under field conditions. American Journal Veterinary Research. 67(8):1–9. 2006.

VI. Lista-Alves D, Palomares-Naveda R, García F, Obando C, Arrieta D, Hoet AE*. Serological evidence of

Neospora caninum in cattle herds from Venezuela. Veterinary Parasitology. 136(3-4): 347–349. 2006.

VII. Boscán L, Arzálluz A, Ugarte C, Díaz D, Wittum TE, Hoet AE*. Isolation of Salmonellas of Zoonotic Importance in Viscera from Broiler Chickens in Zulia State, Venezuela (Aislamiento de Salmonellas de importancia zoonótica en vísceras de pollos beneficiados en el Estado Zulia, Venezuela). Revista Científica (ISSN 0798-2259). XV (6): 576 - 582. 2005.

VIII. Hoet AE*, Saif LJ. Bovine Torovirus (Breda virus) revisited. Animal Health Research Reviews. 5(2):157-

171. 2004.

IX. Smiley JR, Hoet AE, Traven M, Tsunemitsu H, Saif LJ. Reverse transcription-PCR assays for detection of bovine enteric caliciviruses (BEC) and analysis of the genetic relationships among BEC and human caliciviruses. Journal of Clinical Microbiology. 41(7):3089-3099. 2003.

X. Hoet AE, Nielsen PR, Hasoksuz M, Thomas C, Wittum TE, Saif LJ. Detection of Bovine Torovirus and

other enteric pathogens in feces from diarrhea cases in cattle. Journal of Veterinary Diagnostic Investigation. 15(3):205-212. 2003.

XI. Hoet AE, Smiley J, Thomas C, Nielsen PR, Wittum TE, Saif LJ. Association of Bovine Torovirus (Breda

virus) with diarrhea in neonatal veal calves. American Journal Veterinary Research. 64(4):485-490. 2003.

XII. Hoet AE, Chang KO, Saif LJ. Comparison of ELISA and RT-PCR versus Immune Electron Microscopy for detection of bovine torovirus (Breda virus) in calf fecal specimens. Journal of Veterinary Diagnostic Investigation. 15(2):100-106. 2002.

XIII. Hasoksuz M, Hoet AE, Loerch SC, Wittum TE, Nielsen PR, Saif LJ. Detection of respiratory and enteric

shedding of bovine coronaviruses in cattle in an Ohio feedlot. Journal of Veterinary Diagnostic Investigation. 14(4):308-313. 2002.

XIV. Hasoksuz M, Sreevatsan S, Cho KO, Hoet AE, Saif LJ. Molecular analysis of the S1 subunit of the Spike

glycoprotein of respiratory and enteric bovine coronavirus isolates. Virus Research. 84(1-2):101-109. 2002.

XV. Hoet AE, Cho KO, Chang KO, Loerch S, Wittum T, Saif LJ. Enteric and nasal shedding of bovine torovirus (Breda virus) in feedlot cattle. American Journal of Veterinary Research. 63(3):342-348. 2002.

XVI. Cho KO, Hoet AE, Loerch SC, Wittum TE, Saif LJ. Evaluation of concurrent shedding of bovine

coronavirus via the respiratory tract and enteric route in feedlot cattle. American Journal of Veterinary Research. 62(9):1436-1441. 2001.

XVII. Hoet A*, D’Pool G, Fulcado W, Polo R, Graterol C, Brito M. Isolation of coagulase positive Staphylococcus

spp, other than Staphylococcus aureus, from quarters with subclinical mastitis in la Villa del Rosario, Estado Zulia, Venezuela (Aislamiento de estafilococos coagulasa positivos, distintos a Staphylococcus aureus, de cuartos con mastitis subclínica en la Villa del Rosario, Estado Zulia, Venezuela). Revista Científica. IX(2):149-153. 1999.

http://www.geocities.com/atiliojose/Boscan.pdf

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XVIII. Hoet A*, Landaeta A, Aranguren A, Mendoza A, Martínez H, Díaz D, Sol J, Partidas D. Cross-antigenicity in Bovine Brucellosis (Antigenicidad cruzada en Brucelosis Bovina). Revista Científica. January-April VII(1): 5-7. 1997.

XIX. Hoet A*, Carruyo G, Gutiérrez E, Bravo M. Evaluation of manual washing and disinfection methods of

teatcups between cows: comparison between two culture media (Evaluación de métodos manuales de lavado y desinfección de pezoneras entre vacas: comparación de dos medios de cultivo). Revista Científica. January-April, VI(1): 21-30. 1996.

XX. Negron, G; Parra, O; Ávila, N; Hoet, A. Experimental effects of the Enterolobium cyclocarpum (Kara-

Kara) fruit in cattle (Efecto experimental de la ingestión del fruto Enterolobium cyclocarpum (Kara Kara) en el ganado bovino). Revista Científica. January-June III(1):62-67. 1993.

XXI. Rodas A, Hoet A, Arraga C, Alvarado M, Fernández E. Adamantinoma (ameloblastoma) in an adult bovine

a clinical, radiological and histopathological study, A case report (Un Caso de Adamantinoma (ameloblastoma) en un Bovino Adulto: Estudio Clínico, Radiológico e Histopatológico). Revista Científica. January-June II(1):69-75. 1992.

- CONFERENCE PROCEEDINGS, ABSTRACTS

I. Narvaez-Bravo C, Fuenmayor Y, Rodas-González A, Flores C, Carruyo G, Moreno M, Wittum T, Hoet AE.

Distribution of Salmonella spp. during slaughter of cattle (Distribución de Salmonella spp. durante el faenado del ganado vacuno). IX Congreso Latinoamericano de Microbiología e Higiene de Los AlimentosInternacional Congreso. Margarita, Venezuela.12-14 Mayo, 2007.

II. Heider LC, Hoet AE, Funk JA, Wittum TE. Genetic and phenotypic characterization of the CMY-2 β-

lactamase gene from E. coli and Salmonella spp. isolated from food-producing animals, the environment, and retail meat. Conference of Research Workers in Animal Diseases (CRWAD). Chicago, Illinois, USA. December 4-6, 2006. Number 61, p 141.

III. Briceño L, Narváez-Bravo C, Rodas-González A, Wittum TE, Hoet AE. Dissemination of Salmonella spp. in a

Large Poultry Slaughter Plant. 52nd International Congress of Meat Science and Technology (ICoMST). Dublin, Ireland; August 13-18, 2006. p 313.

IV. Boscán LA, Arzálluz AM, Ugarte C, Damarys S, Wittum T, Hoet AE. Resistance to Quinolones by

Salmonella isolated from slaughter chicken poultry (No. 73). Conference of Research Workers in Animal Diseases (CRWAD). St. Louis, Missouri, USA. December 4-6, 2005.

V. Nava-Trujillo H, Soto-Belloso E, Hoet AE. Effects of Pre-Service Clinical Mastitis on Reproductive

Performance of Dual Purpose Cows. Fourth IDF International Mastitis Conference. Maastricht, The Netherlands. June 12-15, 2005.

VI. Thomas C, Hoet AE, Sreevatsan S, Wittum TE, Briggs R, Duff G, Saif LJ. Bovine coronavirus (BCoV)

transmission and herd protection in feedlot cattle (No. 59). Conference of Research Workers in Animal Diseases (CRWAD). Chicago, Illinois, USA. November 14-16, 2004.

VII. Thomas C, Hoet AE, Smiley J, Nielsen PR, Wittum TE, Saif LJ. Association of Bovine Torovirus (Breda

virus) with Diarrhea in Neonatal Veal Calves (No. 104). Conference of Research Workers in Animal Diseases (CRWAD). St. Louis, Missouri, USA. November 10-12, 2002.

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VIII. Wang QH, Han MG, Hoet AE, Saif LJ. Hemagglutination by Cowden porcine enteric calicivirus and development of a hemagglutination-inhibition test (No. 102). Conference of Research Workers in Animal Diseases (CRWAD). St. Louis, Missouri, USA. November 10-12, 2002.

IX. Hoet AE, Sreevatsan S, Saif LJ. Molecular analysis of the 5’end of the spike gene of bovine torovirus

(Breda virus) field strains (W48-3). American Society for Virology, 21st Annual Meeting. Lexington, Kentucky, USA. July 2002.

X. Hoet AE. Detection of Bovine Torovirus and other enteric pathogens in feces from gastroenteritis cases in

cattle. 41st Annual North Central Conference of Veterinary Laboratory Diagnosticians. Ohio Department of Agriculture, Division of Animal Industry. Reynoldsburg, Ohio, USA. June 10-11, 2002.

XI. Hoet AE, Hasoksuz M, Nielsen PR, Wittum TE, Saif LJ. Prevalence of Bovine Torovirus and other enteric

pathogens in feces from clinical gastroenteritis cases from cattle (No. 18). 2002 Ohio Agriculture Research and Development Center Annual Conference. Wooster, Ohio, USA. April 2002.

XII. Hoet AE, Hasoksuz M, Nielsen PR, Wittum TE, Saif LJ. Prevalence of Bovine Torovirus in feces from

clinical gastroenteritis cases from cattle in Ohio (No. 116). Conference of Research Workers in Animal Diseases. St. Louis, Missouri, USA. November 14, 2001.

XIII. Hoet A, Cho K, Chang K, Loerch S, Wittum T, Saif L. Prevalence of Bovine Torovirus and other enteric

pathogens in feces from clinical gastrointestinal cases in cattle. Annual Meeting of the American Association of Bovine Practitioners. Vancouver, British Columbia, Canada. September 13-16, 2001.

XIV. Hoet A, Carruyo G, Gutiérrez E, Bravo M. Comparison of Two Manual Methods of Washing and

Disinfection of Teatcups during the Milking Routine on the reduction of Staphylococcus species. pp 476-477. Second International Mastitis and Milk Quality Symposium. Vancouver, British Columbia, Canada. September 13-15, 2001.

XV. Hoet A, Cho K, Chang K, Loerch S, Wittum T, Saif L. Enteric and nasal shedding of Bovine Torovirus

(Breda virus) by feedlot cattle (W53-12). American Society for Virology, 20th Annual Meeting. University of Wisconsin, Madison, WI, USA. July 21-25, 2001.

XVI. Hasoksuz M, Hoet AE, Loerch S, Wittum TE, Saif LJ. Detection of respiratory and enteric shedding of

Bovine Coronaviruses by ELISA and RT-PCR in feedlot cattle. P24-7. American Society for Virology, 20th Annual Meeting. University of Wisconsin, Madison, Wisconsin, USA. July 21-25, 2001.

XVII. Hoet AE, Cho KO, Chang KO, Loerch S, Wittum TE, Saif LJ. Enteric and nasal shedding of Bovine

Torovirus (Breda virus) by feedlot cattle (EAR4). Advances in Veterinary Medicine. Columbus, Ohio. April 12, 2001.

XVIII. Hoet AE, Cho KO, Chang KO, Loerch S, Wittum TE, Saif LJ. Enteric and nasal shedding of Bovine

Torovirus (Breda virus) by feedlot cattle (No. 21). 2001 Ohio Agriculture Research and Development Center Annual Conference. Columbus, Ohio, USA. April 05, 2001.

XIX. Hoet AE, Cho KO, Chang KO, Loerch S, Wittum TE, Saif LJ. Enteric shedding of Bovine Torovirus (Breda

virus) in infected feedlot cattle (No. 77). Conference of Research Workers in Animal Diseases. Chicago, Illinois, USA. November 12-14, 2000.

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XX. Hoet A, Carruyo G, Castejón O, Gutiérrez E, Bravo M. Comparison of two bacterial media in the evaluation of manual washing and disinfection methods of teatcups between cows. Pan-American Congress on Mastitis Control and milk Quality. Mérida, Yucatan, Mexico. March 23-27, 1998.

XXI. Hoet A, Landaeta A, Mendoza A, Martínez H, Díaz D, Sol J, Partidas D. Cross-Antigenicity in Brucellosis.

XV Pan-American Congress of Veterinary Sciences (PANVET). Campo Grande, Mato Grosso, Brazil. October 22-24, 1996.

XXII. Rivera S, Hoet A, Pérez M. Serology evidence of Blue Tongue in Bovine of Perija District, Zulia State,

Venezuela (Evidencias serológicas de Lengua Azul en bovinos del Distrito Perija del Estado Zulia). XXII Microbiology Venezuelan Conferences supported by The Venezuelan Society of Microbiology (XXII Jornadas Venezolanas de Microbiología, avaladas por la Sociedad Venezolana de Microbiología). Mérida, Venezuela. November 1994.

- JOURNAL ARTICLES NOT REVIEWED

I. Hoet AE. Leptospira, an old problem without good news (Leptospira, un viejo problema sin buenas noticias). Producción y Negocio (The main target audience of this journal are farmers, agro-businesses and agro-industry). Barinas, Venezuela. March 1:24-25. 2004.

II. Hoet AE. New technologies to approach Bovine Mastitis (Nuevas tecnologías para abordar la Mastitis

Bovina). Contacto Veterinario (The main target audience of this journal are veterinary practitioners and students, as well as farmers). Maracaibo, Venezuela. June 3(5):11. 2003.

III. Hoet A. Economic repercussion of abortion produced by Brucella (Repercusión económica de los abortos

causados por Brúcela). La Matera (The main target audience of this journal are farmers, agro-businesses and agro-industry). Maracaibo, Venezuela. Nov-Dic, 56:36-40. 1996.

IV. Hoet A. What is the Bovine Brucellosis? (¿Que es la Brucelosis Bovina?). Revista Agropecuaria Circulo

Ganadero de Venezuela (The main target audience of this journal are farmers, agro-businesses and agro-industry). 63:19-22. 1992.

- EDITORIALS

• Hoet AE. Editorial for Peer-Reviewed journal “Revista Científica” of the College of Veterinary Sciences (ISSN

0798-2259). XIII (5):1-2.

- EDUCATIONAL MATERIALS • Author of the Spanish versions of fact sheets prepared for the OSU Extension. Epidemiologist’s West Nile virus

Extension Program. April 2006. WNV-1000-06. Frequently asked questions about birds and West Nile virus (Spanish). WNV-1001-06. Farmers and West Nile virus (Spanish). WNV-1002-06. What outdoor enthusiasts should know about West Nile virus (Spanish). WNV-1003-06. People and West Nile virus: Frequently asked questions (Spanish). WNV-1004-06. West Nile virus and scrap tires (Spanish). WNV-1005-06. West Nile virus fact sheet for veterinarians (Spanish). WNV-1006-06. Frequently asked questions about wildlife and West Nile virus (Spanish). WNV-1007-06. What horse owners should know about West Nile virus (Spanish). WNV-1008-06. Wetlands and West Nile Virus (Spanish). * Corresponding author

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9. PUBLICATIONS AND SCHOLARLY CONTRIBUTIONS IN PREPARATION

- BOOK CHAPTERS IN PREPARATION • Hoet AE*, Marian C. Horzinek. Toroviruses (Coronaviridae). Encyclopedia for Virology, Third Edition.

Elsevier. Under editorial review. - PEER REVIEWED JOURNAL ARTICLES IN PREPARATION

I. Harvey R, Funk JA, Wittum TE, Hoet AE*. Proportion and diversity of tetracycline resistance genes in

fecal community DNA samples from conventional and antibiotic free reared beef cattle. Microbial Drug Resistance. In preparation (final editing).

II. Thomas CJ, Han MG, Hoet AE, Saif LJ. Cross-protection studies between two bovine enteric calicivirus

strains associated with different genera. American Journal of Veterinary Research. In preparation (final editing).

III. Thomas CJ, Han MG, Hoet AE, Saif LJ. Seroprevalence studies of bovine noroviruses and Nebraska-like

bovine enteric caliciviruses in feedlot cattle and veal calves in the USA. American Journal of Veterinary Research. In preparation (final editing).

IV. Nava-Trujillo H, Soto-Belloso E, Hoet AE*. The effects of clinical mastitis before first service on dual

purpose cows reproductive performance. Theriogenology. In preparation (final editing).

V. Nava-Trujillo H, Soto-Belloso E, Hoet AE*. Effect of parity and the postpartum clinical mastitis occurrence on interval to first service and conception of dual purpose crossbred cows. Revista Científica. In preparation (final editing).

VI. Van-Balen J, D’Pool G, Gil1 M, Escalona F, Hoet AE, Díaz D. Seroprevalence from 1998 to 2001 of

Leptospira spp. in cattle of Zulia state, Venezuela. Revista Científica. In preparation (final editing).

VII. Nava RC, Boscán L, Arzálluz A, Wittum TE, Hoet AE*. Risk factors associated with Salmonella shedding in cattle under tropical conditions. Target journal has not been selected. In preparation (writing first draft).

VIII. Nava RC, Boscán L, Arzálluz A, Lopez Y, Wittum TE, Hoet AE*. Antimicrobial resistance patterns of

Salmonella spp. isolated from dual purpose cattle under tropical conditions. Target journal has not been selected. In preparation (writing first draft).

IX. Nava RC, Boscán L, Arzálluz A, Lopez Y, Wittum TE, Hoet AE*. First report of a clinical outbreak of

Salmonella Dublin in a dual purpose cattle herd in Venezuela. Revista Científica. In preparation (writing first draft).

10. CURRENT ACTIVE RESEARCH • Genetic and phenotypic characterization of β-lactamases CMY-2 genes from E. coli and Salmonella spp.

isolated from food-producing animals, the environment, and meat products. In collaboration with Dr. Thomas Wittum and Dr. Wondwossen Gebreyes from the Department of Veterinary Preventive Medicine, The Ohio State University, Columbus, Ohio. 2005-Present.

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• Designing of biotyping methods for E. coli to be used in epidemiological studies. In collaboration with Dr. Thomas Wittum from the Department of Veterinary Preventive Medicine, The Ohio State University, Columbus, Ohio; and Dr. Julie Funk from Michigan State University, East Lansing, Michigan. 2005-Present.

• Effects of low dietary vitamin A on animal health and quality and nutritional characteristics of beef. In

collaboration with Drs Steve Loerch and Linda J Saif from the Ohio Agricultural Research and Development Center (OARDC), The Ohio State University. 2006-Present.

• Epidemiological studies on Salmonella ecology and patterns of antimicrobial resistance in Dual Purpose Dairy

Farms under tropical conditions. Venezuelan Salmonella Project. In collaboration with Dr. Thomas Wittum, from the Department of Veterinary Preventive Medicine, The Ohio State University, Columbus, Ohio, USA; and Dr. Claudia Narvaez, from the Department of Transmissible Diseases, College of Veterinary Medicine, The University of Zulia, Maracaibo, Venezuela. 2003-Present

• Studies on Salmonella serotypes and their patterns of antimicrobial resistance isolated from Poultry Carcasses.

Venezuelan Salmonella Project. In collaboration with Dr. Thomas Wittum, from the Department of Veterinary Preventive Medicine, The Ohio State University, Columbus, Ohio, USA; and Dr. Claudia Narvaez, from the Department of Transmissible Diseases, College of Veterinary Medicine, The University of Zulia, Maracaibo, Venezuela. 2003-Present

• Epidemiological studies on Leptospirosis in Venezuela. In collaboration with Dr. Dubraska Díaz, Coordinator

of the Leptospirosis Research Unit, Department of Transmissible Diseases, College of Veterinary Medicine, The University of Zulia, Maracaibo, Venezuela. 2003- Present

11. GRANT AWARDS AND FELLOWSHIPS

• Passive and Active Surveillance of Methicillin-Resistant Staphylococcus aureus at the Ohio State University

Veterinary Hospital. Hoet AE (PI). Canine research funds, College of Veterinary Medicine, The Ohio State University. In process ($15.000)

• Interdisciplinary Public Health Preparedness Program for Emerging Infectious Disease threats: from discovery

to Application. Co-Principal Investigators: KH Hoblet, L Schlesinger, TE Buckley. AE Hoet- Co-Investigator. Funded by Targeted Investment in Excellence from the Provost office ($4,788,947). 2006.

• Prevalence and antimicrobial sensitivity of Salmonella and E. coli strains in simples from poultry carcasses,

bovines and fresh eggs (Prevalencia y sensibilidad a los antimicrobianos de cepas de Salmonella y E. coli O157:H7 en muestras de canales de aves, bovinas y huevos frescos). Claudia Narvaez (PI). Hoet AE (CoPI). In collaboration with Dr. Thomas Wittum, The Ohio State University. Research grant award from Council for the Scientific and Humanistic Development of the University of Zulia (Consejo de Desarrollo Científico y Humanístico del Zulia, CONDES), Maracaibo, Venezuela. ($9,300). November 2004.

• Serological survey and risk factors of Leptospira spp. and Brucella canis in dogs under veterinarian care

(Encuesta serológica y factores de riesgo de Leptospira spp. y Brucella canis en perros bajo consulta Veterinaria). Dubrazca Díaz (PI). Hoet AE (CoPI). Research grant award from Council for the Scientific and Humanistic Development of the University of Zulia (CONDES), Maracaibo, Venezuela. ($9,000). November 2004.

• Enteric and nasal shedding of Bovine Torovirus (Breda virus) by feedlot cattle. Hoet AE (PI). Research grant

award from The Research Enhancement Competitive Grants Program, at The Ohio Agricultural Research and Development Center (OARDC), The Ohio State University, Wooster, Ohio, USA. ($2,500). 2001.

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• Winner of a Scholarship to obtain a Doctoral degree at The Ohio State University in the U.S.A. Awarded by the

Venezuela Government and the National Council for Scientific Research and Technology (CONICIT) through a national contest in Venezuela. Caracas, Venezuela June 1997 to May 2002.

• Comparison of two manual methods of washing and disinfection of teatcups during the milking routine on the

reduction of Staphylococcus species (Comparación de dos métodos manuales de lavado y desinfección de pezoneras durante la rutina de ordeño sobre la reducción de Staphylococcus especies). Gabriela Carruyo (PI), Hoet AE (CoPI). Research grant award from Council for the Scientific and Humanistic Development of the University of Zulia (CONDES), Maracaibo, Venezuela. ($1,500). February 1994.

• Winner of a Fellowship for a Training Program in Teaching, Research and Extension in Infectious Diseases.

Department of Transmissible Diseases, College of Veterinary Sciences, The University of Zulia. Two-year program awarded through a competitive process. February 1993.

12. RESEARCH GRANT PROPOSALS IN PROCESS OR SUBMITTED

• Genetic and phenotypic characterization of β-lactamases CMY-2 genes from E. coli and Salmonella spp.

isolated from food-producing animals, the environment, and meat products. Hoet AE (PI),Wittum TE (CoPI). USDA animal health (formula funds), College of Veterinary Medicine, The Ohio State University. In process (final editing)

• Seroprevalence and shedding of canine respiratory coronavirus in shelter dogs. Saif LJ (PI), Hoet AE (CoPI).

Pfizer. Submitted August 2006. • Reducing Enteric Pathogens in Dairy Wastewater with an Ecological Treatment System. Jay Martin (PI), Hoet

AE (Co-PI). United States Department of Agriculture, Cooperative State Research, Education, and Extension Service. ($400,000). Not funded. 2006.

• Human Resources Development and Training of Doctors of Veterinary Medicine with the Master of Public

Health Specialized In Veterinary Public Health (DVM-MPH/VPH Program). Hoet AE and Thomas Wittum (PIs). US Department of Homeland Security. ($13,000,000). Not funded. 2006.

• Salmonella fecal shedding in dual-purpose dairy cattle under tropical conditions. Hoet AE (PI), Wittum TE

(CoPI). US Department of Agriculture (USDA), Foreign Agricultural Service, Scientific Cooperation Research Program. ($45,000.00). Not funded. 2005.

13. TUTOR ACTIVITIES

- MASTERS OF PUBLIC HEALTH ADVISOR • Ashbaugh Hayley, BA. Project: Not assigned yet. Degree: Master of Public Health – Veterinary Public Health

Specialization. The Ohio State University. 2006-Present. Self-support. Advisor. • Hough Kellie, DVM. Project: Not assigned yet. Degree: Master of Public Health – Veterinary Public Health

Specialization. The Ohio State University. 2006-Present. Self-support. Advisor. • Hull Lisa, DVM. Project: Not assigned yet. Degree: Master of Public Health – Veterinary Public Health

Specialization. The Ohio State University. 2006-Present. Self-support. Advisor.

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• Millette Jennifer, BS. Project: Retrospective Study of Salmonella Prevalence in Ohio. Degree: Master of Public Health – Veterinary Public Health Specialization. The Ohio State University. 2006-Present. Self-support. Advisor.

• Stolte Jennifer, BS. Project: Not assigned yet. Degree: Master of Public Health – Veterinary Public Health

Specialization. The Ohio State University. 2006-Present. Self-support. Advisor. • Wroniak Elissa, BS. Project: MRSA and Environmental contamination in veterinary health settings. Degree:

Master of Public Health – Veterinary Public Health Specialization. The Ohio State University. 2006-Present. Self-support. Advisor.

• Rogers Amanda, BS. Project: Horse related injuries in Ohio. Degree: Master of Public Health – Veterinary

Public Health Specialization. The Ohio State University. 2005-Present. Advisor. • Gosset Melissa, BS. Project: Service Dogs and Biological Event Response. Degree: Master of Public Health –

Veterinary Public Health Specialization. The Ohio State University. 2005-Present. Self-support. Graduated May, 2007. Advisor.

• Sayre Jennifer, BS. Project: Zoonotic Diseases Reference Document for the Ohio Department of Health.

Degree: Master of Public Health – Veterinary Public Health Specialization. The Ohio State University. Graduated May, 2007. Advisor.

• Johnson Amanda, BS. Culminating project: Passive and active surveillance program of Methicillin-Resistant

Staphylococcus aureus at the Ohio State University Veterinary Hospital. Degree: Master of Public Health – Veterinary Public Health Specialization. The Ohio State University. Graduated September, 2006. Advisor.

• Harvey Rebekah, BS. Culminating Project: Proportion and diversity of tetracycline resistance genes in fecal

community DNA samples from conventional and antibiotic free reared beef cattle. Degree: Master of Public Health – Veterinary Public Health Specialization. The Ohio State University. Graduated September, 2006. Advisor.

- MASTERS THESIS ADVISOR • Boscan Leonardo, DVM. Master Thesis: Salmonella detection in poultry viscera from two slaughter plants in

Zulia State, and the study of their behavior against different antimicrobials. Degree: Magister Scientiarum in Avian Medicine and Production. College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. Graduated December, 2004. Advisor.

- MASTERS OF PUBLIC HEALTH COMMITTEES

• Daniel Buckland. Practice Based Communication and Disease Reporting Survey of Ohio Veterinarians. Master

of Public Health. The Ohio State University, School of Public Health and Department of Veterinary Preventive Medicine. Advisor: William Saville. Graduated Spring 2007. Advisory Committee Member.

• Brooks Aimee, BS. Project: A retrospective study of Leptospirosis in Ohio animal between 2002 - 2005. Master

of Public Health. The Ohio State University, School of Public Health and Department of Veterinary Preventive Medicine. Advisor: Fred Degraves. Graduated Spring 2007. Advisory Committee Member.

• Dunson Angela J, BS. Project: Efficacy of 2.5% Acetic Acid Solution to Reduce the Incidence of Generic E.

coli on the Round, Midline, and Brisket of Beef Carcasses. Master of Public Health. The Ohio State University,

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School of Public Health and Department of Veterinary Preventive Medicine. Advisor: Paivi Rajala-Schultz. Graduated Winter 2007. Advisory Committee Member.

• Rory Daley, BS. Antimicrobial Resistance of Coagulase-negative Staphylococci Isolated from Bovine Milk at

Dry-off and Calving and Implications for Public Health. Degree: Master of Public Health – Veterinary Public Health Specialization. The Ohio State University. Graduated Autumn 2006. Advisory Committee Member.

- MASTERS THESIS STUDENT COMMITTEES • White James, BS. Thesis: Design and validation of methods to quantify antimicrobial resistance genes using

tet(C) as a model. Degree: Master Science in Veterinary Preventive Medicine. The Ohio State University. 2005 - Present. Advisory Committee Member.

• Thomas Christopher, DVM. Thesis: Epidemiology of Bovine Coronavirus and Bovine Calicivirus (Norovirus).

Degree: Master Science in Veterinary Preventive Medicine. The Ohio State University. Graduated August, 2005. Advisory Committee Member.

• Lista Deisy M., DVM. Thesis: Serological evidence of Neospora caninum in selected herds in Venezuela.

Degree: Specialist in Bovine Reproduction. College of Veterinary Sciences. The University of Zulia, Maracaibo, Venezuela. Graduated June, 2004. Associate Advisor.

• Nava Jesús A., DVM. Thesis: Postvaccination reactions, immune response, histopathological changes, and

productive parameters in poultry chicken under to vaccination programs against Newcastle. Degree: Magister Scientiarum in Avian Medicine and Production. College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. Graduated March, 2004. Associate Advisor.

- DOCTORAL DISSERTATION STUDENT COMMITTEES

• Angela Allen, MPH. Dissertation: Malaria. Degree: Doctor of Philosophy. The Ohio State University, College

of Public Health, Epidemiology Division. Advisor: Randall Harris. 2006-Present. Advisory Committee Member.

• Abley Melanie, BS. Dissertation: The quantification of Salmonella and Campylobacter using Real-time PCR

and the most probable number (MPN) method. Degree: Doctor of Philosophy. The Ohio State University, Department of Veterinary Preventive Medicine. 2006-Present. Advisory Committee Member.

• Heider Luke, DVM. Dissertation: Epidemiology of Beta-lactamase resistance in Escherichia coli: molecular

analysis of the CMY-2 genes. Degree: Doctor of Philosophy. The Ohio State University, Veterinary Preventive Medicine. 2005-Present. Advisory Committee Member.

• Morgan Jennie, BS. Dissertation: Water quality improvement and plant root function in an ecological system

treating dairy wastewater. Degree: Doctor of Philosophy. Environmental Science Program, College of Food, Agricultural, & Environmental Science. Columbus, Ohio. 2005-Present. Advisory Committee Member.

• Valero Kutchyskaya, Bioanalyst. Dissertation: Epidemiology of Mastitis in dual-purpose dairy farms. Degree:

Doctor in Microbiology. Central University of Venezuela (Universidad Central de Venezuela). Caracas, Venezuela. 2004-Present. Co-Advisor.

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- TRAINING SUPERVISOR AND VISITING SCHOLARS • El-Nasser Asmaa Abd, DVM, PhD. Visitor from the College of veterinary Medicine at Assiut University,

Assiut, Egypt. This activity was part of the Midwest Universities Consortium for International Activities (MUCIA) project. September, 2005. Host.

• Narvaez Claudia, DVM, MSc. Training in diagnostic techniques such as rPCR and microbiological culture

methods for food borne pathogens. The Ohio State University, Department of Veterinary Preventive Medicine. August 2005 to September 2005. Training Supervisor.

• Arrieta Darwuin, DVM. Training in diagnostic techniques such as: ELISA, RT-PCR, Hemagglutination, and

cell culture methods. Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University. February 2002 to April 2002. Training Supervisor.

• Díaz Dubrazca, DVM. Training in diagnostic techniques such as: ELISA, RT-PCR, Hemagglutination, and cell

culture methods. Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University. May 2001 to June 2001. Training Supervisor.

• Thomas Christopher, DVM. Training in diagnostic techniques such as: ELISA, RT-PCR, Hemagglutination,

and cell culture methods. Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University. October 18-26 1999. Training Supervisor.

14. TEACHING

- OHIO STATE UNIVERSITY • VPM 101 Introduction to Veterinary Medicine (3 credit hours). Team member. Didactic lecture

course for undergraduate students with interest in Veterinary Medicine. Lecture (2 hours) on Veterinary Public Health. Spring quarter, 2007.

• VPM 723 Biosecurity, Environmental Health, and other Veterinary Public Health Topics (4 credit

hours). Team member. Didactic lecture course for MPH-VPH students and graduate students from veterinary preventive medicine and other departments. Spring quarter, 2007.

• PH-EHS 530 Current Topics in Environmental Health (4 credit hours). Team Member. Didactic lecture

course at the College of Public Health for undergraduate students pursuing a minor in Public Health. Lectures (2 hours) on Zoonotic and Vector Borne Diseases. Winter quarter, 2007.

• VPM 722 Food borne diseases, food animal production systems, and food safety (4 credit hours).

Team Co-Leader. Didactic lecture course for MPH-VPH students and graduate students from veterinary preventive medicine and other departments. Winter quarter, 2007.

• PUB-HLTH 400 Introduction to Public Health. Team Member. Didactic lecture course at the College of

Public Health for undergraduate students pursuing a minor in Public Health. Lectures (2 hours) on Zoonotic disease and veterinary public health. Winter quarter, 2007.

• VM 510 Principles of Epidemiology (4 credit hours). Team Member. Didactic lecture course for 1st

year veterinary students. Lectures (2 hours) on Tropical Animal Population Systems. Autumn quarter, 2006.

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• VPM 721 Epidemiology of Zoonoses and Diseases Common to Animals and Humans (4 credit hours). Team Leader. Didactic lecture course for MPH-VPH students and graduate students from veterinary preventive medicine and other departments. Autumn quarter, 2006.

• VPM 696 International Topics in Veterinary Public Health (2 credit hours). Team Leader. Didactic

lecture course for graduate students with interest in VPH international issues. Summer quarter, 2006. • VPM 101 Introduction to Veterinary Medicine (3 credit hours). Team member. Didactic lecture

course for undergraduate students with interest in Veterinary Medicine. Lecture (1 hour) on Veterinary Public Health. Spring quarter, 2006.

• VPM 723 Biosecurity, Environmental Health, and other Veterinary Public Health Topics (4 credit

hours). Team member. Didactic lecture course for MPH-VPH students and graduate students from veterinary preventive medicine and other departments. Spring quarter, 2006.

• VPM 722 Food borne diseases, food animal production systems, and food safety (4 credit hours).

Team Leader. Didactic lecture course for MPH-VPH students and graduate students from veterinary preventive medicine and other departments. Winter quarter, 2006.

• VM 510 Principles of Epidemiology (4 credit hours). Team Member. Didactic lecture course for 1st

year veterinary students. Lectures (2 hours) on Tropical Animal Population Systems. Autumn quarter, 2005. • VPM 796.04 Epidemiology of Zoonoses and Diseases Common to Animals and Humans (4 credit

hours). Team Leader. Didactic lecture course for MPH-VPH students and graduate students from veterinary preventive medicine and other departments. Autumn quarter, 2005.

• VPM 820 Clinical Epidemiology (2 credit hours). Team member. Philosophy of clinical epidemiology

for graduate students. Collaborator during discussion sections. Summer quarter, 2005. - THE UNIVERSITY OF ZULIA • Infectious Diseases (3 lecture credit hours 4 laboratory credit hours). Team Leader. Didactic and laboratory

lectures (including field and laboratory exercises) in infectious diseases for all 4th year veterinary students. Teach twice a year in semester periods. College of Veterinary Medicine. Maracaibo, Venezuela. 2003-2004

• Infectious Diseases (3 lecture credit hours 4 laboratory credit hours). Team member and Team leader of

laboratory lectures. Didactic and laboratory lectures (including field and laboratory exercises) in infectious diseases for all fourth year veterinary students. Teach twice a year in semester periods. College of Veterinary Medicine. Maracaibo, Venezuela. 2002-2003.

• Infectious Diseases (3 lecture credit hours 4 laboratory credit hours). Team member and Team leader of

laboratory lectures. Didactic and laboratory lectures (including field and laboratory exercises) in infectious diseases for all fourth year veterinary students. Teach twice a year in semester periods. College of Veterinary Medicine. Maracaibo, Venezuela. 1995-1997.

• Infectious Diseases (3 lecture credit hours 4 laboratory credit hours). Team member. Didactic lectures as well

as field and laboratory exercises in infectious diseases for all fourth year veterinary students. Teach twice a year in semester periods. College of Veterinary Medicine. Maracaibo, Venezuela. 1993-1995.

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- OTHER INSTITUTIONS • Medicine for Ruminants (4 credit hours) Team member. Didactic lectures for graduate students in the Master

and PhD program at the College of Veterinary Sciences, Universidad Central de Venezuela (Venezuelan Central University). Maracay, Venezuela. Lecture (3 hours) on Enteric Viruses. July, 2004.

• Medicine for Ruminants (4 credit hours) Team member. Didactic lectures for graduate students in the Master

and PhD program at the College of Veterinary Sciences, Universidad Central de Venezuela (Venezuelan Central University). Maracay, Venezuela. Lecture (3 hours) on Enteric Viruses. July, 2003.

15. INVITATIONS FOR CONFERENCES, SEMINARS, COURSES, LECTURES, WORKSHOPS • CDC atlanta • Bill Epperson certificate program • Protecting Animals and People from Bioterrorism. Presented at the 2007 Ohio Veterinary Medical

Association Pre-Veterinary Medicine Conference. Columbus, Ohio. February 24, 2007. • An Overview of Veterinary Emergency Response Training in the Professional Curriculum. Presented in

collaboration with Dr. F. Degraves at the Midwest Veterinary Conference sponsored by the Ohio Veterinary Medical Association. Columbus, Ohio. February 22, 2007.

• Repercussion of Bovine Mastitis on Reproduction (Repercusión de la Mastitis Bovina en la Reproducción).

Presented at the course “One day for Reproduction” (Un día para la Reproducción), XXXVII meeting of the Group of Researchers in Animal Reproduction of the Zulian Region (Grupo de Investigadores de la Reproducción Animal en la Región Zuliana, GIRARZ). GIRARZ Foundation, College of Veterinary Sciences, The University of Zulia, Maracaibo, Venezuela. December 2004.

• Instructor of the training course “Update in Bovine Mastitis” (Actualización sobre Mastitis Bovina).

Sponsor by Bayer®. Nine lectures and several field activities were performed in this training course designed for Veterinarians. Santa Polonia, Mérida, Venezuela. October 29-30, 2004.

• Bovine Torovirus: A new headache? (Torovirus Bovino: ¿Un nuevo dolor de cabeza?). Presented at XXXV

Anniversary Journey of the Venezuelan Society of Microbiology, Zulia Chapter (Jornadas XXXV Aniversario Sociedad Venezolana de Microbiología Capitulo Zulia). Maracaibo, Venezuela. October 15-16, 2004.

• Invited Lectures / Instructor Workshop held during the course “Profitable management of dual-purpose dairy

farms” (Manejo Rentable de Fincas Ganaderas de Doble Propósito). Sponsor by Venezuelan Artificial Insemination and Embryo Transplant Company (Venezolana de Inseminación Artificial y Transplante de Embriones CA, VIATECA). Four lectures and field activities were performed in the following topics: “Physiopathology of Bovine Mastitis” (Fisiopatología de la mastitis bovina), “Economical Losses” (Perdidas Económicas), “Biosecurity of Reproductive Diseases” (Bioseguridad de las Enfermedades Reproductivas), and “Procedures for a Successful Vaccination” (Procedimiento para una Vacunación Exitosa). La Villa del Rosario, Zulia, Venezuela. This course was offered in three opportunities: December 2003, April 2004, and September 2004.

• Biosecurity of Reproductive Diseases (Bioseguridad de las Enfermedades Reproductivas). Presented at the

course “One day for Reproduction: Update in Bovine Reproduction” (Un día para la Reproducción: Avances en Reproducción Bovina), XXXVI meeting of the Group of Researchers in Animal Reproduction of the Zulian

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Region (GIRARZ). GIRARZ Foundation, College of Veterinary Sciences, The University of Zulia. El Vigía, Mérida, Venezuela. June 2004.

• Invited Presentation “Biosecurity of Reproductive Diseases” (Bioseguridad de las Enfermedades

Reproductivas) at the course “One day for Reproduction: Update in Bovine Reproduction” (Un día para la Reproducción: Avances en Reproducción Bovina), XXXVI meeting of the Group of Researchers in Animal Reproduction of the Zulian Region (GIRARZ). GIRARZ Foundation, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. November 2003.

• Invited Presentation “Bovine Torovirus: A new headache?” (Torovirus Bovino: ¿Un nuevo dolor de

cabeza?) at the I Journey of Research and Graduate Studies, Dr. Ramón Parra Atencio (Jornadas de Investigación y Postgrado, Dr. Ramón Parra Atencio). College of Veterinary Sciences, The University of Zulia, Maracaibo, Venezuela. October 2003.

• Invited Presentation “Bovine Torovirus: A new headache?” (Torovirus Bovino: ¿Un nuevo dolor de

cabeza?) at the I Technical Journey UNESUR and the II Workshop in Basic Sciences (I Jornadas Técnicas UNESUR 2002 y II Taller de Ciencias Básicas). La Universidad Nacional Experimental Sur del Lago “Jesús Maria Semprum”. Santa Bárbara del Zulia, Zulia, Venezuela. December 2002.

• Invited Translator Lecturer of the course “Veterinary Epidemiology, new approaches for Disease

Eradication” (Epidemiología Veterinaria, nuevos enfoques en la erradicación de enfermedades), sponsor by the Extension Division and the Division for Graduate Studies (División de Extensión y División de Estudios para Graduados), College of Veterinary Sciences, The University of Zulia; and PIPSA-FONACIT. Maracaibo, Venezuela. March 22-23, 2002.

• Invited presentation “Economical impact of abortion by Leptospirosis” (Impacto económico del aborto por

Leptospirosis) at the seminar “Leptospirosis effects in rural areas” (Efecto de la Leptospirosis en el medio Rural), sponsor by the Extension Division, College of Veterinary Sciences, The University of Zulia. Mene Grande, Zulia, Venezuela. April 1997.

• Invited presentation “Training opportunities of the Extension Division of the College of Veterinary

Sciences” (Oferta de Capacitación de la División de Extensión) at the workshop “Identification and promotion of training opportunities for the agriculture development of Venezuela” (Taller para la Identificación y Promoción de la Oferta de Capacitación para el Desarrollo Agrícola de Venezuela). Sponsor by The Hemispheric Training System for Agricultural Development (Sistema Hemisférico de Capacitación para el Desarrollo Agrícola, SIHCA), Inter-American Institute for Cooperation on Agriculture (IICA), and Foundation CIARA. Caracas, Venezuela. December 1996.

• Invited presentation “Brucellosis as a Zoonoses” (Brucelosis como Zoonosis) at the I National Journeys on

Zoonotic Diseases, Dr. José Francisco Torrealba (I Jornadas Nacionales sobre Enfermedades Zoonóticas), sponsor by the Central-Occident University “Lisandro Alvarado” (La Universidad Centro Occidental Lisandro Alvarado, UCLA) the Pan-American Health Organization (PAHO), the Ministry of Health and Social Assistance, and the Ministry of Agriculture and Breeding (Ministerio de Sanidad y Asistencia Social, y Ministerio de Agricultura y Cría). Barquisimeto, Lara, Venezuela. May 23-25, 1996.

• Invited presentation “Economical impact of Bovine Leptospirosis” (Impacto Económico de la Leptospirosis

Bovina) at the I Regional workshop on Bovine Leptospirosis to the south of Maracaibo Lake” (I Taller Regional de Leptospirosis Bovina Sur del Lago), sponsor by the Farmers Association Alberto Adriani and the Andes University (Universidad de los Andes). El Vigía, Mérida, Venezuela. May 1996.

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• Invited presentation “Procedures for a successful vaccination” (Procedimiento para una Vacunación Exitosa) at the seminar “Vaccines and vaccinations in bovines” (Vacunas y Vacunaciones en Bovinos), sponsor by Veterinary Student Research Center (CIEV) and the Research Division , College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. April 26-27, 1996.

• Invited presentation “Extension Division of the College of Veterinary Sciences” (División de Extensión de

la Facultad de Ciencias Veterinarias) at the cycle of conferences “Actions of the Zulia Government to strength the agro-food system in the region” (Acciones del Gobierno del Zulia para el Fortalecimiento del Circuito Agroalimentario de la Región). Zulia State Government and its Agro-Food Division (Dirección Agroalimentaria). Maracaibo, Venezuela. November 1995.

• Invited presentation “Economic Repercussions of Abortions Caused by Brucella and Leptospires”

(Repercusión económica de los abortos causados por Brucelas y Leptospira) at the International Course on Dual-Purpose Cattle (Curso Internacional de Ganadería de Doble Propósito). GIRARZ Foundation, College of Veterinary Sciences, The University of Zulia, Maracaibo, Venezuela. November 9-11, 1995.

• Invited presentation “Economic Repercussions of Bovine Brucellosis” (Repercusión económica de la

Brucelosis Bovina) at the course “Essential factors to increase the reproductive efficiency in cattle herd” (Factores esenciales para incrementar la eficiencia reproductiva en la Ganadería Bovina), sponsor by the Extension Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. October 1995.

• Invited presentation “Is it Possible Students’ Research? Narrative of past experiences” (¿Es Posible la

Investigación Estudiantil? Relato de experiencias pasadas), at the Forum on “Students’ Research, it is Possible?” (Foro Investigación Estudiantil, ¿Es Posible?), sponsor by Veterinary Student Research Center (CIEV) and the Research Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. June 1994.

• Instructor / Invited Lectures “Economic losses due to Bovine Mastitis” (Pérdidas económicas causadas por

la Mastitis Bovina) and “Preventive and control measures to avoid Mastitis in mechanical milking” (Medidas de prevención y control de la Mastitis en ordeño mecánico), at the course “Mastitis: Problems and Solutions” (Mastitis: Problemas y Soluciones), sponsor by the Extension Division, College of Veterinary Sciences, The University of Zulia.

This extension course involved lectures and hand-on activities at farm level and it was held in three different occasions:

- At the Farmers Union of la Villa del Rosario (Unión de Ganaderos de la Villa del Rosario, UGAVI). La Villa del Rosario, Zulia, Venezuela. June 1994.

- At the Company Industrias Lácteas C.A. (INDULAC). Santa Bárbara, Zulia, Venezuela. December 1993.

- At the Farmers Union of la Pica (Asociación de Ganaderos de la Pica, AGAPICA). Balmore Rodríguez, Zulia, Venezuela. April 1993.

• Invited presentation “Economic losses due to Bovine Brucellosis” (Pérdidas Económicas causadas por

Brucelosis Bovina) at the seminar “Latest Topics in Bovine Reproduction” (Temas de Actualidad en Reproducción Bovina), sponsor by the Extension Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. November 1993.

• Invited presentation “Mastitis: Contagious or Environmental. A new Classification” (Mastitis: Contagiosa

o Ambiental. Una nueva clasificación) at the course “Latest topics in Cattle Herds” (Tópicos de actualización en

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Ganadería Bovina), sponsor by the Extension Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. September 9-10, 1993.

• Invited presentation “Evaluation of Rumen’s Liquor” (Evaluación del Licor Ruminal) at the course

“Physiopathology of the Ruminants Stomachs” (Fisiopatología de los Estómagos del Rumiante), sponsor by the Extension Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. October 2-3, 1992.

• Invited presentation “Economic losses due to Bovine Brucellosis” (Pérdidas Económicas causadas por la

Brucelosis Bovina) at the X Agriculture Journeys of the Farmers Union of La Villa del Rosario (X Jornadas Agropecuarias de UGAVI). La Villa del Rosario, Zulia, Venezuela. September 1992.

• Invited presentation “Infectious Pneumonia in Calves” (Neumonía Infecciosa en Terneros), at the IX

Agriculture Journeys of the Farmers Union of La Villa del Rosario (IX Jornadas Agropecuarias de UGAVI). La Villa del Rosario, Zulia, Venezuela. September 1991.

• Invited presentation “Veterinary Student Research Center” (Centro de Investigación Estudiantil de

Veterinaria, CIEV) at the II Seminar of Research and Self-development of the University of Zulia (II Seminario de Investigación y Auto-desarrollo de La Universidad del Zulia), sponsor by the Vice-rectory for Academics Affairs of the University of Zulia (Vicerrectorado Académico de La Universidad del Zulia). Maracaibo, Venezuela. September 1990.

• Invited presentation “Situation of Student’s Research at the College of Veterinary Sciences” (Situación de

la Investigación a nivel Estudiantil en la Facultad de Ciencias Veterinarias), at the II Seminar of Research and Self-development of the University of Zulia (II Seminario de Investigación y Auto-desarrollo de La Universidad del Zulia), sponsor by the Vice-rectory for Academics Affairs of the University of Zulia (Vicerrectorado Académico de La Universidad del Zulia). Maracaibo, Venezuela. September 1990.

16. MEMBERSHIPS IN SCIENTIFIC AND PROFESSIONAL SOCIETIES • 2006-Present Member of the Conference of Research Workers in Animal Diseases • 2003-Present Foundation “Friends of the Scientific Journal of the Collage of Veterinary Sciences of the

University of Zulia” (Fundación Amigos de la Revista Científica de la Facultad de Ciencias Veterinarias de la Universidad del Zulia). Founder Member.

• 2000-Present Associate Member of the American Society of Virology. USA. • 1998-Present Member of the National Mastitis Council. USA. • 1995-Present Group of Researchers in Animal Reproduction of the Zulian Region (Grupo de Investigadores

de la Reproducción Animal en la Región Zuliana, GIRARZ). • 1991-2004 Association of Professors of The University of Zulia. Maracaibo, Venezuela • 1991-2004 Veterinarian Association of Zulia State. Maracaibo, Venezuela.

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17. SCIENTIFIC REVIEWING • Judge in the Food Safety and Epidemiology Poster Section at the 86th “Annual Meeting of the Conference of

Research Workers in Animal Diseases.” Chicago, Illinois. December 3, 4, and 5 2006. • Molecular epidemiology of bovine toroviruses circulating in South Korea. Veterinary Microbiology • Prevalence of ecto and endoparasites in pregnant and weaning sows under four management systems. Archivos

Latinoamericanos de ProducciÃ³n Animal • Revista Científica FCV-LUZ. College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela.

“Development and standardization of indirect Elisa with Lps of Salmonella Anatum”. June 2006.

• Scientific and Technical Review of the OIE (World Organization for Animal Health). “Serological evidence of coronavirus infection in mithuns (Bos frontalis) from India”. April 2006.

• Virus Research (an International Journal of Molecular and Cellular Virology). “The Complete sequence of the

Bovine Torovirus genome”. May 2005.

• Revista Científica FCV-LUZ. College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. 2002-Present (12 articles).

• Revista Científica FCV-LUZ. College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela.

“Evaluation of a Duplex PCR Assay for the identification of Mycobacterium tuberculosis Complex and Nontuberculous Mycobacteria (Identification of Mycobacteria)”. May 2005.

• Judge of the Food Safety Section at the 86th “Annual Meeting of the Conference of Research Workers in

Animal Diseases.” St. Louis, MI. December 4, 5, and 6, 2005. • Judge of Research Day at the College of Veterinary Medicine from The Ohio State University. Columbus, Ohio.

April 14th, 2005.

• I Journey of Research and Graduate Studies, Dr. Ramón Parra Atencio (I Jornadas de Investigación y Postgrado “Dr. Ramón Parra Atencio”). College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. October 2003 (5 manuscripts and presentations).

• Judge in the “XXV Young Regional Science Festival” (XXV Festival Juvenil Regional de la Ciencia,

ASOVAC). Event sponsored by the Venezuelan Association for the Advance of Science (Asociación Venezolana para el Avance de la Ciencia). Maracaibo, Venezuela. June 21-24 1994.

18. OTHER ACADEMIC/SERVICE ACTIVITIES • Member of The Ohio Veterinary Emergency Response team (OVER). This is an organization sponsored and

led by The Ohio Department of Agriculture. The main purpose of this group is to be prepared for and respond to animal health events, incidents or emergencies, as a part of the national effort of the Department of Homeland Security following the National Response Plan. April 2005.

• Member of the Organizing Committee of the course “One day for Reproduction” (Un día para la Reproducción),

XXXVII meeting of the Group of Researchers in Animal Reproduction of the Zulian Region (Grupo de

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Investigadores de la Reproducción Animal en la Región Zuliana, GIRARZ). GIRARZ Foundation, College of Veterinary Sciences, The University of Zulia, Maracaibo, Venezuela. December 2004.

• Member of the Scientific Committee for the XXXIX Veterinary School Anniversary Week (XXXIX Semana

Aniversario de la Facultad de Ciencias Veterinarias). Event sponsored by the College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. May 3-7, 2004.

• Member of the Organizing Committee of the “II Forum of Zoonotic Diseases” (II Foro sobre Enfermedades Zoonóticas). Event sponsored by the College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. April 2004.

• Member of the Organizing Committee for the activity “One day for the Animal Production Experimental Center,

CEPA” (Un día para el Centro Experimental de Producción Animal, CEPA). Event sponsored by the College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. March 2004.

• Member of the Scientific Committee for the “I Journey for Research and Graduate Studies of the College of

Veterinary Sciences” (I Jornadas de Investigación y Postgrado de la Facultad de Ciencias Veterinarias). Event sponsored by the Research Division and the Division of Graduate Studies, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. October 9-10, 2003.

• Member of the Scientific Committee for the XXXVIII Veterinary School Anniversary Week (XXXVIII Semana

Aniversario de la Facultad de Ciencias Veterinarias). Event sponsored by the College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. May 5-9, 2003.

• Coordinator of the “I Forum of Zoonotic Diseases” (I Foro de Enfermedades Zoonóticas). Event sponsored by the

Extension Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. May 2003. • Coordinator and Moderator of the Forum “Bovine Spongiform Encephalitis or Mad Cow, A dangerous

Zoonosis?” (Encefalitis Espongiforme Bovina o Vaca Loca ¿Una Zoonosis Peligrosa?). Event sponsored by the Extension Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. May 1996.

• Coordinator of the conference “A General Vision for Aquaculture” (Una Visión General de la Acuicultura).

Event sponsored by the Extension Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. May 1996.

• Coordinator of the seminar “Vaccines and Vaccinations in Bovines” (Vacunas y Vacunaciones en Bovinos).

Event sponsored by the Veterinary Student Research Center (CIEV) and the Research Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. April 26-27, 1996.

• Coordinator of the “Training course in Mastitis Diagnosis” (Curso de Entrenamiento en Diagnóstico de

Mastitis). Event sponsored by the Research Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. November 1995.

• Coordinator of the Animal Health Section in the International Course in Dual Purpose Cattle (Curso

Internacional de Ganadería de Doble Propósito). Event sponsored by the College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. November 9-10, 1995.

• Moderator of the Forum “Awakening, Professional Practices 94” (Forum Despertares, Pasantías 94). Event sponsored by the Veterinary Student Research Center (CIEV) and the Research Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. November 1994.

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• Coordinator of the training course “Mastitis: Problems and Solutions”. (Mastitis: Problemas y Soluciones). Event sponsored by the Extension Division, Veterinary School, The University of Zulia. La Villa del Rosario, Zulia, Venezuela. July 1994.

• Coordinator of the seminar “Reproduction and Bovine Genetics” (Reproducción y Genética Bovina). Event

sponsored by the Research Division, College of Veterinary Sciences, The University of Zulia. Maracaibo, Venezuela. April 1991.

19. VETERINARY PUBLIC HEALTH PROGRAM: I. OVERVIEW The Veterinary Public Health position was created in 2005 as a new position (0.65 FTE Didactic Education Veterinary Public Health program; 0.05 FTE Administration; 0.05 FTE Scholarship and Research) in the Veterinary Preventive Medicine Department. The main responsibility of this position is to coordinate of the new Veterinary Public Health specialization towards the Master of Public Health degree (MPH-VPH). The MPH-VPH degree is a partnership between the School of Public Health (SPH) and The College of Veterinary Medicine (CVM), in which the SPH provides the MPH and the CVM provides the VPH specialization. The first responsibility for the coordinator of the program was to design the curriculum of the VPH specialization. To accomplish this goal the coordinator used the ideal curriculum for veterinary public health/preventive medicine proposed by the American College of Veterinary Preventive Medicine as the core base for the specialization. Also performed numerous interviews with the faculty members of the Department of Veterinary Preventive Medicine to obtain a broader view of what a veterinary public health program should be. The main objective of the VPH specialization is to educate and train professionals with the skills, knowledge, and resources to protect and improve human health by using “one Medicine” approach. Graduates of this program will have the ability to develop and execute crucial public and private health programs designed to prevent and control zoonotic diseases in both animals and humans. They will also learn about other important topics related to Veterinary Public Health such as food-borne diseases, food safety, environmental health issues, biosecurity practices and bioterrorism. The program will also provide a strong background in biostatistics and epidemiology. The MPH degree is the standard professional public health degree recognized throughout the world. During the MPH-VPH program, it is required that all students take at least one course in each one of the five areas of knowledge basic to public health: biostatistics, environmental health sciences, epidemiology, health behavior and health promotion, and health services management and policy. So the students can gain flexibility and familiarity with all public health disciplines. Required courses for the veterinary public health specialization include zoonotic diseases (VPM 721), foodborne diseases and food safety (VPM 722), and biosecurity, environmental health and other VPH issues (VPM 723). Through these courses the students will gain knowledge on the epidemiology and ecology of zoonotic diseases in pet animal, livestock, and human populations. Students also learn about animal population systems, including the roles of companion and food-producing animals in society, food production and distribution systems, biosecurity programs, and intervention strategies. As a practice-oriented degree, the MPH also requires that all students to fulfill a field practicum designed to gain practical experience in the VPH field; as well as to complete a culminating experience (apply field research project) also focused in a VPH relevant area. There is close collaboration with several federal, state, and local Public Health institutions, where our students are performing their practice placements and culminating experiences, among them: Ohio Department of Health - Bureau of Infectious Disease Control, ODH - Division of Prevention, Ohio Department

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of Agriculture - Animal Disease Diagnostic Lab, ODA - Consumer Analytical Laboratory, ODA - Department of Meat Inspection, Columbus Health Department, USDA-APHIS-VS, and US geological service, among others. The MPH-VPH program is designed to be completed in 1.5–2 years, depending on individual courses, practice placement experience, and the culminating experience project chosen by the student. Nevertheless, in the first cohort two very proactive students graduated in only one year. The veterinary public health specialization within the MPH program at Ohio State provides students with the public health credentials to serve as leaders in zoonoses prevention and control programs in the U.S. and worldwide. This is the only MPH program in the US that offers a Veterinary Public Health specialization. Upon completion of the program, the graduates will be well prepared for a rewarding career in both state and federal governments, non-governmental organizations, industry, and agribusiness. Public health professionals with MPH degrees and specialized training in veterinary public health will have expanded opportunities for professional development. The veterinary public health specialization can also be easily tailored for students who intend to enter the Doctor of Veterinary Medicine (DVM) curriculum as well as other professional programs at Ohio State or elsewhere. Students in the veterinary public health specialization who are accepted into a DVM program after the first year can still complete their MPH degree. These students will work closely with their advisor to complete the practice placement and culminating experience requirements for the MPH degree during the first two summer quarters. The MPH degree can be awarded prior to the completion of the DVM degree. To date, 6 of 9 MPH-VPH students that have applied to the OSU-CVM were accepted to start their DVM studies next fall 2006. In the first two years of the program the MPH-VPH has received over 88 applications (25 in 2005 & 56 in 2006). We accepted 17 of the best qualified students for the cohort of 2005 and 27 for the cohort of 2006. Both cohorts have been very diverse, as the Veterinary Public Health field is, including several Veterinarians and graduate students from a variety of academic backgrounds including zoology, microbiology, animal sciences, medicine, wildlife biology, and entomology. Of these graduate students at least 50% plan to pursue other professional degrees after the MPH-VPH such as a DVM or MD. It is also important to highlight that the MPH-VPH program brings excellent revenues to the university, the CVM, and the School of Public Health; as well as local and national recognition to the CVM. II. DETAILS OF THE VETERINARY PUBLIC HEALTH SPECIALIZATION A. COURSES As part of the responsibilities of the veterinary public health position was to design and develop three new graduate level courses, which will be the core courses for the VPH specialization; as well as to develop some possible electives to complement the training of the MPH-VPH students. The designed courses are here described. VPM 721 - Epidemiology of Zoonoses and diseases common to animals and humans (4 credit hours – Autumn quarter). This course is focused on describing the basic epidemiology of common and important Zoonotic diseases. Instruction emphasizes the use of such knowledge in the establishment of preventive and control strategies specific for these zoonoses. The importance of safeguarding animal and public health from such diseases is highlighted throughout the course. This course is divided into two major sections; the aim of the first section is to develop an understanding of important concepts on animal infectious diseases. The second section is a comprehensive review of the most common zoonotic diseases that can be transmitted to humans. Special topics about VPH and small animal populations, wildlife, and laboratory animals are also covered. VPM 722 - Food borne diseases, food animal production systems, and food safety (4 credit hours – Winter quarter). This course is divided in three sequenced blocks of information. In the first section, the students receive an overview of how the food chain for the most common products of animal origin works, with special emphasis in pre-harvest safety issues. In the following section, the most common food-borne diseases will be described in detail,

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with special emphasis in their epidemiology and transmission. Finally, during the last block of information, food safety issues such as hazard analysis, good management practices, meat inspection, and food safety training will be discussed. VPM 723 - Biosecurity, Environmental Health, and other Veterinary Public Health Topics (4 credit hours – Spring quarter). This course is divided in three blocks of information. In the first section, the students receive an overview on biosecurity issues with special emphasis in bioterrorism, preparedness, risk assessment, and management of zoonotic and food-borne outbreaks. In the following segment, the most common environmental health issues related to human and animal interactions are described in detail, focusing on water and air quality, waste management and carcass disposal, among others. The last section provide additional topics about Veterinary Public Health, such as animal bites, non-infectious consequences of animal and human interactions, animals as models for diseases and sentinels, and drug and pharmaceutical residues. VPM 696 – International Veterinary Public Health Topics (2 credit hours – Summer quarter). This course is designed to describe the most important Foreign Animal and Zoonotic Diseases (FAZD) in different geographical regions of the world. Diseases are described with special emphasis on their local and regional epidemiology, transmission, updated statistics, and any recent outbreak information. Specific preventive and control measures for each disease applied in the different geographical areas are discussed. The most important differences with the US are highlighted with potential impact should a particular exotic disease occur in this country. Specific risk assessment of possible entry and/or outbreak emergence of such diseases in the US are also discussed. B. RECRUITMENT ACTIVITIES The primary target audience in addition to veterinarians included graduated students that apply to the CVM and other professional colleges. To reach and address the target audiences, several modalities have been used:

1. Development and establishment of MPH-VPH web pages. Web pages for the CVM and the SPH web sites were designed to promote the program and answer the most common questions of future applicants. The CVM web pages contain a brief description of the VPH field, the MPH program at OSU, and the Veterinary Public Health Specialization. Also, the specific requirements needed to apply to the VPH Program are listed and explained in this web page; as well as a summary of the requirements to obtain the MPH-VPH degree among other valuable information. The SPH web pages contain a very detail description of the MPH program; as well as the required courses, typical electives, and examples of practicum for the VPH specialization. 2. Development and distribution of promotional material. a. Brochure and Fact sheet. A brochure and fact sheets containing detail information about the MPH-VPH program were designed in conjunction with the SPH and the CVM. These promotional material have being actively distributed to future candidates, as well as personalities involved in the veterinary public health field. The brochure is easy available at different offices at the CVM and SPH. The brochure have being also distributed in major academic and scientific events such as the National Conference on establishing an Academic Network on Foreign Animal and Zoonotic Disease (April 6 - 8, 2005), the Conference of Research Workers in Animal Diseases (CRWAD, St. Louis, December, 2005), OVMA conference (Columbus, Ohio, February, 2005 and 2006), A Day at CDC for Veterinary Students conference (January 23, 2006), Public Health Surveillance using a “One-Medicine” approach conference (June 16, 2006), among others.

b. Promotional Package (MPH-VPH packet) Our office prepared the MPH-VPH packet (counselor package), which contains a booklet and brochure from the School of Public Health as well as a brochure and introduction to the MPH-VPH program. In addition, the

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summary of requirements to obtain a MPH-VPH degree, the general schedule for a full time student, possible elective options, and the full description of the program are included in the packet. This package has been widely distributed to places that regularly submit students to apply to the OSU-CVM, which is one of our major target groups. The MPH-VPH packet has been sent to different departments at OSU, among them: animal sciences, zoology, microbiology, entomology, and biology. We have also sent such packet to counselor’s offices of the top colleges remitting students to the OSU-CVM such as, Miami State University, Bowling Green University, University of Findlay, among others. Letters and information packets describing the MPH-VPH program have been mailed or directly provided to public health officials from the different federal and state agencies. Among them USDA-APHIS-Veterinary Services, Food and Drug Administration - Center for Veterinary Medicine, Centers for Disease Control and Prevention - Veterinary Medicine and Public Health, USDA-APHIS- Animal Care, Food Safety and Inspection Service, CSREES - Veterinary Science, CDC/ Division of Emergency & Environmental Health Science , DOD Veterinary Service Activity, Ohio Department of Agriculture – Animal Disease Diagnostic Laboratory, ODA – Consumer Analytical Laboratory, Ohio Department of Health. Other institutions that have received the MPH-VPH packet are the American Veterinary Medicine Association (AVMA), and the American Association of Veterinary Medical Colleges (AAVMC). 3. Presentations and open houses. 2006

School of Public Health open house. Ohio Union, The Ohio State University. Columbus, Ohio. April 20, 2006. Description of the MPH-VPH program. Conference of the Ohio Veterinary Medicine Association (OVMA). Columbus, Ohio. February 11, 2006. Description of the Veterinary Public Health field and the MPH-VPH program. Office of minority affairs (OMA), The Ohio State University. Columbus, Ohio. February 02, 2006. Description of the Veterinary Public Health field and the MPH-VPH program. Department of Animal Science, The Ohio State University. Columbus, Ohio. January 18, 2006. Description of the Veterinary Public Health field and the MPH-VPH program. Findlay University. Findlay, Ohio. January 17, 2006.

2005

Description of the Veterinary Public Health field and the MPH-VPH program. Findlay University. Findlay, Ohio. November 23, 2005. School of Public Health open house. Ohio Union, The Ohio State University. Columbus, Ohio. November 16, 2005. School of Public Health open house. Ohio Union, The Ohio State University. Columbus, Ohio. April 18, 2005. Description of the MPH-VPH program. Conference of the Ohio Veterinary Medicine Association (OVMA). Columbus, Ohio. February, 2005.

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4. Personal Interviews The coordinator has interviewed over 80 possible candidates to the MPH-VPH program, personally or over the phone. During the interview process the profile of the candidate is obtained by filling an interview form designed to determine if the individual has the basic requirements to apply to the MPH-VPH program. The candidate also received a detail description of the MPH-VPH program. If the future student is qualified to apply, all the necessary information and material for the application process is provided or mailed to the future applicant. 5. Lay Publications/Interviews/Press Releases Channel 10 WBNS, Eyewitness News at 5:00 pm, Columbus, Ohio. Segment in TV news. “New Veterinary Public Health program at OSU”. Angela An reporter. September 27, 2005. onCAMPUS. Article: “Program for International and Homeland Security working to safeguard country”, by: Joni Bentz Seal (onCAMPUS staff). This article indicated that the MPH-VPH program offers a new educational initiative that addresses the prevention and control of Zoonotic and food-borne diseases. Page 8, September 22, 2005. The BG News. Electronic article: “Veterinary health benefits everyone”, by Stephanie Bergh. June 24, 2005. onCAMPUS. News Briefs: “New Vet specialization focuses on Public Health”. Inform about the program and the application deadlines. Page 11, May 5, 2005. The Lantern. Article: “New veterinary option to fight diseases”, by Stephanie Bergh (Lantern staff writer). Complete description of the new MPH-VPH program. Front page, April 25, 2005. 6. Promotional meetings with Dr. Karen Alsbrooks, Director of Office of Minority Affairs (OMA), The Ohio State University. December 08, 2005 Dr. Daniel Harpster. Area Emergency Coordinator, USDA-APHIS. June 02, 2005. Dr. Lawrence Heider. Executive Director of the American Association of Veterinary Medical Colleges (AAVMC). April 22, 2005 Dr. Andy Maccabe. Associate Executive Director of the American Association of Veterinary Medical Colleges (AAVMC). April 25, 2005 Dr. Tim Moore. Liaison of the USDA in the Department of Homeland Security. April 19, 2005 7. Invitation letters to future candidates a. Applicants to the OSU-CVM. Letters and brochures informing about the MPH-VPH program were sent to students that applied to the OSU-CVM in 2005 and received an invitation from the College for an interview, but did not made the final cut. Even though these individuals were not accepted at the CVM, they are still excellent students with all the necessary credentials to fulfill the requirements of the MPH-VPH program. Through our letter we encouraged them to apply to the MPH-VPH program, because we believe that this degree is an excellent way to expand their health sciences knowledge and training. Therefore, the MPH-VPH program will help this group of students to improve their profile before reapplying to the College of Veterinary Medicine. Even if the students do not gain access to the CVM, the MPH-VPH degree is valuable and will provide the skills and training required for a rewarding professional career in the growing field of public health. b. Office of Minority Affairs (OMA) at The Ohio State University. In conjunction with the Office of Minority Affairs the coordinator prepared over 100 letters along with a brochure (initial contact package) that were sent out to the colleges and universities that regularly send minority

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undergraduate students to OSU to pursue future graduate programs. Through this information we promoted and provided a general overview of what the MPH-VPH program is and what kind of students our office is actively pursuing.

8. Street posters Sets of posters were prepared and distributed in strategic places around the OSU campus, to help promote the program and reach students with interest in the VPH field. 9. Newsletter Since 2005, a regular update about the MPH-VPH program has being published in the Newsletters from the Department of Veterinary Preventive Medicine, The Ohio State University. C. RULES AND REGULATIONS The coordination of the VPH program has designed and prepared the different rules and regulations, as well as administrative and logistic procedures for the MPH-VPH program. The different rules and protocols are in accordance to those of the SPH and the Department of Veterinary Preventive Medicine. Specific procedures and regulations for evaluation and acceptance of candidates, control of current students, practice placement, and the different culminating experiences have been prepared. All of them have been or will be included in the SPH student handbook. D. FUTURE PLANS 1. Distance Education Program Because there is a large number of veterinarians and other professionals in both public and private practice that have shown interest in the VPH-MPH program but are not able to attend to the face-to-face program. We are currently exploring with the School of Public Health the possibility of offering an online version of the MPH-VPH program through a distance education program (DEP). With this objective the coordinator have performed several meetings or attended conferences to obtain detail information about the structure and management of DEPs. Some of the most important meetings are: Multiple meetings with Daryl Jordan, Director of Information and Technology, to study the technical feasibility of a DEP at the OSU-CVM.

Project Management and Budgeting for Distance Education and Courses in Distance Education. Workshop presented at the 22nd Annual Conference on Distance Teaching and Learning. Organized by the University of Wisconsin. Madison, Wisconsin, USA. August 2-4, 2006.

Distance education Conference, University of Wisconsin. Madison, Wisconsin, USA. August 2-4, 2006.

Dr. Julie Funk, Program Director of the online Master Science, National Food Safety & Toxicology Center, Michigan State University. July 25, 2006

Dr. William Hueston, Director for the Center for Animal Health and Food Safety, University of Minnesota. March 28, 2006.

Dr. Danelle Bickett-Weddle, Associate Director for the Center for Food Security and Public Health, Iowa State University. February 23, 2006.

Basic structure and characteristics of the MPH-VPH distance education program have been designed and are currently under further developing.

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2. Accreditation The coordinator has been in contact with Dr. David W. Dreesen, Executive Vice President of the American College of Veterinary Preventive Medicine (ACVPM), to study the possibility to accredit the MPH-VPH program at the ACVPM. Basic requirements have being already provided and are under study. 20. CURRENT COLLABORATORS

- United States: • Thomas Wittum, PhD. Associate Professor. Department of Veterinary Preventive Medicine, The Ohio State

University. • July Funk, DVM, PhD. Associate Professor. National Food Safety & Toxicology Center, Michigan State

University. • Linda J Saif, MS, PhD. Professor. Food Animal Health Research Program, Ohio Agricultural Research and

Development Center, The Ohio State University. • Jay Martin, PhD. Assistant Professor. Environmental Science Program, College of Food, Agricultural, &

Environmental Science, The Ohio State University. • Wondwossen Gebreyes, DVM, PhD, Diplomate ACVPM. Associate Professor. Department of Veterinary

Preventive Medicine, The Ohio State University. • Steven C Loerch, PhD. Professor. Department of Animal Sciences, College of Food, Agricultural, &

Environmental Sciences, The Ohio State University. - Venezuela: • Claudia Narvaez, DVM, MSc. Assistant Professor. Microbiology section, College of Veterinary Sciences, The

University of Zulia. • Leonardo Boscan, DVM, MSc. Assistant Professor. College of Veterinary Sciences, The University of Zulia. • Disney Pino, DVM, MSc. Associate Professor. College of Veterinary Sciences, The University of Zulia.

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NAME: Daniel J. Wozniak CURRENT ACADEMIC TITLE: Professor ADDRESS: Office: Division of Infectious Disease, Microbiology

1018 Biomedical Research Tower 460 West 12th Avenue Columbus, OH, 43210

Office phone number and email address (614) 247-7629, [email protected] EDUCATION: Institution Dates Degree Field Aquinas College 1978-1982 B.S. Biology, cum laude The Ohio State 1984-1989 Ph.D. Microbiology University DOCTORAL DISSERTATION: Daniel J. Wozniak. 1989. Regulation and Structure-Function Studies of Pseudomonas aeruginosa Exotoxin A. The Ohio State University, Columbus, OH. Advisor: Darrell R. Galloway, Ph.D. POSTDOCTORAL TRAINING: Institution Dates Degree Field University of 1989-1992 Postdoctoral Fellow Microbiology Tennessee Funded by NIH Training grant (1 year) and Cystic Fibrosis Foundation Fellowship (2 years).

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ACADEMIC APPOINTMENTS: October 2008 Professor Medicine, Division Infect. Disease and Microbiology The Ohio State University October 2008 – Present Adjunct Professor Department of Microbiology and Immunology, Wake Forest University School of Medicine July 2008 to October 2008: Professor Department of Microbiology and Immunology, Wake Forest University School of Medicine July 2002 to July 2008 Associate Professor with tenure Department of Microbiology and Immunology, Wake Forest University School of Medicine July 1998 to July 2002: Associate Professor Department of Microbiology and Immunology, Wake Forest University School of Medicine November 1992 to June 1998: Assistant Professor Department of Microbiology and Immunology, Wake Forest University School of Medicine November, 1989 to November, 1992: Post Doctoral Research Fellow Department of Microbiology and Immunology, University of Tennessee. September 1984 to October 1989: Doctoral Student, Department of Microbiology,

The Ohio State University PROFESSIONAL APPOINTMENTS AND ACTIVITIES:

• 2008-2012, Standing member Cystic Fibrosis Foundation Research and Research Training Committee

• 2008-2010, Editorial Board, Molecular Microbiology • 2001-2009, Editorial Board of Journal of Bacteriology • 2005-2008, Ad hoc grant reviewer, Cystic Fibrosis Foundation • 2007-2008, Ad hoc grant reviewer, NIH LCMI Study Section • 2005, Chair ZRG1 IDM NIH Study Section • 2002-2006, Bacteriology and Mycology, BACP Study Section Member, NIH • 2001-2002 Ad hoc grant reviewer, Bacteriology and Mycology (2) Study Section Member, NIH

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• 2001-2003 Professional Consultant, Abbott Laboratories • 2000 Ad hoc grant reviewer, Cystic Fibrosis Foundation • 2000 Ad hoc grant reviewer, American Cancer Society • 1997-2000 Ad hoc grant reviewer, NIH • 1995-Present Ad hoc grant reviewer, National Science Foundation • 1995-Present Ad hoc reviewer, Molecular Microbiology. • 1992-Present Ad hoc reviewer, Journal of Bacteriology • 1992-Present Ad hoc reviewer, Microbiology

INSTITUTIONAL SERVICE (Since 2004): 2004-2005 2005-2006 Biosafety Biosafety Faculty recruitment committee (4) Faculty recruitment committee (2) Committee for undergraduate medical education Committee for undergraduate medical

education Phase 2 medical education committee Phase 2 medical education committee Planning committee, faculty research retreat 2006-2007 2007-2008 Biosafety Biosafety Faculty recruitment committee (2) Committee for undergraduate

medical education Committee for undergraduate medical education Recombinant DNA guidelines committee Recombinant DNA guidelines committee RAC subcommittee space guidelines RAC subcommittee space guidelines LCME Basic Science Committee LCME Basic Science Committee LCME Self Study Committee PROFESSIONAL MEMBERSHIPS AND SERVICE: Memberships:

• American Society for Microbiology • American Association for the Advancement of Science • Beta Beta Beta National Biological Honor Society

Service:

• 2007, North American Cystic Fibrosis Conference. Anaheim, CA, Session Co-chair, “Interactions of Pathogens and the CF Host.”

• 2007, American Society for Microbiology-sponsored "Biofilms 2007" Conference, Quebec City, Canada, Session organizer, The Slime Matrix: What, Where, Why?

• 2007, American Society for Microbiology Annual meeting symposium organizer. Toronto, CA, Biofilm vs. Planktonic: Molecular Nature of the Lifestyle Switch

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• 2007, Williamsburg CFF Conference. Pseudomonas working group participant. • 2007, Chair Mid-Atlantic Microbial Pathogenesis • 2006, American Association of Pharmaceutical Scientists. San Antonio, TX. Roundtable

discussion leader, Bacterial biofilm as a new target in the discovery of new antibiotic drugs.

• 2006, FASEB Summer Research Conference, Tucson AZ. Symposium organizer. The matrix of Pseudomonas aeruginosa biofilms.

• 2005, American Society for Microbiology Annual Meeting. Atlanta, GA. Symposium organizer. The matrix of pathogenic bacterial biofilms.

• 2005, American Society for Microbiology Annual Meeting. Atlanta, GA. Colloquium organizer. Therapeutics Beyond Antibiotics.

• 2005, Vice Chair Mid-Atlantic Microbial Pathogenesis • 2004-2005, American Society for Microbiology Division D Chair • 2003, Abbott Laboratories Biofilm Advisory Group meeting, Chicago, IL. Effects of

macrolides on biofilm formation in Pseudomonas aeruginosa. HONORS AND AWARDS:

• 1990-1992, Cystic Fibrosis Foundation Post Doctoral Fellow • 1989, National Institutes of Health Training Grant Fellow • 1988, National American Academy of Microbiology Presidents Fellowship Award • 1988, The Ohio State University Deans Fellowship Award • National American Society for Microbiology Raymond W. Sarber Fellowship Award

PROFESSIONAL INTERESTS: The major goal of our laboratory is to understand the molecular biology and pathogenesis of the bacterium Pseudomonas aeruginosa. This soil and water organism is particularly interesting since it is a common, yet serious opportunistic pathogen. Additionally, P. aeruginosa causes severe pulmonary infections in patients with the genetic disease cystic fibrosis (CF). Failure to control colonization with P. aeruginosa in CF patients is now the major cause of pulmonary debilitation in this group. Our research has centered on identifying and characterizing the genes involved in the regulation of several P. aeruginosa virulence factors. Molecular, biochemical and genetic techniques are used address these issues. GRANTS: CURRENT AND PENDING: Current:

• NIH R01AI061396-01, The matrix of Pseudomonas aeruginosa biofilms, 7/01/05 - 6/30/10, $1,786,867 Direct Cost, (Wozniak, P.I).

• NIH, 2-R01 HL58334-09, Control of P. aeruginosa algD transcription. 12/01/07 – 11/30/12 $1,250,000 Direct Cost (Wozniak P.I.).

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• NIH, 1-R03 AI076561, Pseudomonas Biofilms and Persistence. 12/01/07 – 11/30/09. $100,000 Direct Cost (Wozniak P.I.).

• NIH, R01AI075081, Bordetella Biofilms and Pathogenesis. 09/15/08 – 08/31/12. $250,000 Direct Cost (Deora P.I.).

• Cystic Fibrosis Foundation MA06F0 (Mentor). The role of Psl in P. aeruginosa biofilm development and pathogenesis. 5/01/06-4/30/09. $74,100 Direct Cost (Ma P.I.).

• WFUSM Venture Fund. Mechanism of Pseudomonas extracellular polysaccharide regulation of neutrophil functional responses. 3/01/08 – 3/31/09. $20,000 Direct Cost, (McPhail, P.I).

• NIH F31AI078700, Ruth L. Kirschstein NRSA for Individual Predoctoral Fellowships, The Role of exopolysaccharides in Pseudomonas aeruginosa virulence. 4/01/08 – 3/31/12. $114,560 Direct Cost (Byrd, P.I., Sponsor – Wozniak).

• Cystic Fibrosis Foundation Pilot and Feasibility Grant. Vaccines and adjuvant therapies to prevent Pseudomonas biofilm infections. 4/01/08 – 3/31/10. $80,000 Direct Cost, (Mizel, P.I).

• American Heart Association Predoctoral Fellowship (Mentor). Structure-function and DNA-binding Properties of Pseudomonas aeruginosa AmrZ. 07/01/2008 - 07/01/2010. $40,000 Direct Cost, (Waligora P.I.).

Pending:

• NIH, R01, Small Molecule Control of Bacterial Biofilms. 7/01/08 – 6/30/13, $500,000 Direct Cost (Melander, P.I.).

• NIH, R01, Mutagenesis and pathogenesis of P. aeruginosa. 12/-1/08-11/30/13. $1,807,363 Direct Cost (Sutton, P.I.)

Past Grant History

• WFUSM Venture Fund. Pseudomonas Biofilms and Persistence. 3/01/07 – 3/31/08. $20,000 Direct Cost, (Wozniak, P.I).

• USDA CSREES NRI, 2006-01256 (Meetings Grant). Mid Atlantic Microbial Pathogenesis Meeting. $10,000. (Wozniak, P.I.)

• NIH R13 AI073025-01 (Meetings Grant). Mid Atlantic Microbial Pathogenesis Meeting. $9,000. (Wozniak, P.I.).

• Cystic Fibrosis Foundation WOZNIA06P0. Control of P. aeruginosa algD transcription, 12/01/06 – 11/30/06, $85,000 Direct Cost, (Wozniak, P.I).

• American Heart Association 0515325U (Mentor). Negative Regulation of Flagellar Motility in Pseudomonas aeruginosa by the Alternative Sigma Factor AlgT. 07/01/05 – 06/30/06. $40,000 Direct Cost (Tart P.I.).

• Cystic Fibrosis Foundation (Co-investigator) Host response to mucoid and motile P. aerguinosa 4/1/04 – 3/31/06, $120,000 Direct Cost (Sanchez P.I.)

• NIH 1 R21 AI061396-01, The matrix of Pseudomonas aeruginosa biofilms. 07/01/2004 - 06/30/2005. $255,386 Direct Cost, (Wozniak P.I.).

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• NIH, 1-R01 AI 45779-01, Regulation of P. aeruginosa motility and virulence. 9/1/99 – 8/30/04 $864,603 Direct Cost, (Wozniak P.I.).

• American Heart Association, 0215191U (Ramsey), Structural analysis and DNA-binding Properties of the Pseudomonas aeruginosa transcriptional activator AlgZ. 7/1/02 - 6/30/04, $36,400 Direct Cost. (Ramsey P.I.).

• Abbott Laboratories, ABT-773 study agreement 200021, Mechanistic basis for non ribosomal effects of macrolide treatment on Pseudomonas aeruginosa infections. 7/1/01 – 6/30/03 $124,440 Direct Cost. (Wozniak P.I.).

• Cystic Fibrosis Foundation, 6/01/99 - 5/31/02. Control of P. aeruginosa virulence traits by AlgR. $104,500 Direct Cost. (Erova, P.I.).

• NIH, 1-R01-HL 58334, Control of Pseudomonas aeruginosa algD transcription. $508,394 Direct Cost. (Wozniak, P.I.).

• NIH R-29 FIRST Award. 7/1/94-6/30/99. Role of AlgB in P. aeruginosa Alginate Gene Expression. $350,000 Direct Cost. (Wozniak, P.I.).

• United Way/NIH Biomedical Research Support, 7/1/93-6/30/94. $6,000. (Wozniak, P.I.). • Cystic Fibrosis Foundation, 12/1/93-11/30/94. $73,000, (Wozniak, P.I.). • Cystic Fibrosis Foundation Post Doctoral Fellowship, $104,500, (Wozniak, P.I.).

BIBLIOGRAPHY: Journal articles 50. M. S. Byrd, I. Sadovskaya, E. Vinogradov, H. Lu, A. B. Sprinkle, S. H. Richardson, L. Ma, B. Ralston, M. R. Parsek, E. M. Anderson, J. S. Lam, and D. J. Wozniak. 2009. Genetic and biochemical analyses of the Pseudomonas aeruginosa Psl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production. Mol. Microbiol. Submitted 49. Laurie H. Sanders, D.J. Wozniak, and Mark D. Sutton. 2009. Accurate and error-prone roles for DinB in modulating the mutation frequency of Pseudomonas aeruginosa. DNA Repair. Submitted 48. Melissa Starkey, Jason H. Hickman, Luyan Ma, Niu Zhang, Susan De Long, Aaron Hinz, Sergio Palacios, Colin Maoil, Mary Jo Kirisits, Timothy Starner, D. J. Wozniak, Caroline S. Harwood, Matthew R. Parsek. 2009. Pseudomonas aeruginosa rugose small colony variants have adaptations that likely promote persistence in the cystic fibrosis lung. J. Bacteriol. In Press. 47. Eric T. Weimer, H. Lu, D.J. Wozniak, and S.B. Mizel. 2009. A vaccine containing OprF311-

341/OprI/type A- and B-flagellin fusion proteins provides protection against Pseudomonas aeruginosa. Infect. Immun. In press.

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46. Luyan Ma, M. Conover, H. Lu, M. R. Parsek, K. Bayles, and D.J. Wozniak. 2009. Assembly and development of the Pseudomonas aeruginosa biofilm matrix. PLoS Pathogens. 5:e1000354. 45. Robert W. Huigens, L. Ma, C. Gambino, P.D.R. Moeller, A. Basso, J. Cavanagh, D.J. Wozniak, and C. Melander. 2008. Control of bacterial biofilms with marine alkaloid derivatives. Mol. BioSyst. 4(6):614-621. 44. Belete, B., H. Lu, and D.J. Wozniak. 2008. Pseudomonas aeruginosa AlgR regulates type IV pilus biosynthesis by activating expression of the fimU-pilVWXY1Y2E operon. J. Bacteriol. 190:2023-2030. 43. Andrew J. Leech, A. Sprinkle, L. Wood, D.J. Wozniak, and D.E. Ohman. 2008. The NtrC-family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter. J. Bacteriol. 190:581-589. 42. Hans-Curt Flemming, T, R. Neu, and D.J. Wozniak. 2007. The EPS matrix: The “house of biofilm cells.” J. Bacteriol. 189:7945-7947. 41. Luyan Ma, H. Lu, A. Sprinkle, M. R. Parsek, and D.J. Wozniak. 2007. Pseudomonas aeruginosa Psl is a galactose- and mannose-rich exopolysaccharide. J. Bacteriol. 189:8353-8356. 40. Ryder, C., M. Byrd, and D.J. Wozniak. 2007. Role of polysaccharides in Pseudomonas aeruginosa biofilm development. Current Opinion in Microbiology. 10:1-5. 39. Sanders, L.H., A. Rockel, H. Lu, D. J. Wozniak, and M.D. Sutton. 2006 Role of Pseudomonas aeruginosa dinB-encoded DNA polymerase IV in mutagenesis. J. Bacteriol. 188: 8573-8585. 38. Ma, L., K.D. Jackson, R.M. Landry, M.R. Parsek, and D.J. Wozniak. Analysis of Pseudomonas aeruginosa conditional Psl variants reveals roles for the Psl polysaccharide in adhesion and maintaining biofilm structure post-attachment. J. Bacteriol. 188: 8213-8221. 37. Tart, A.H., M.J. Blanks, and D. J. Wozniak. 2006. The AlgT-dependent transcriptional regulator AmrZ (AlgZ) inhibits flagellum biosynthesis in mucoid, non-motile Pseudomonas aeruginosa cystic fibrosis isolates. J. Bacteriol. 188. 6843-6849. 36. P. J. Baynham, D. M. Ramsey, B. V. Gvozdyev, E. M. Cordonnier, and D. J. Wozniak. 2006. The Pseudomonas aeruginosa ribbon-helix-helix DNA-binding protein AlgZ (AmrZ) controls twitching motility and biogenesis of type IV pili. J. Bacteriol. 188:132-140.

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35. Anne H. Tart, M.C. Wolfgang, and D.J. Wozniak. 2005. The Alternative Sigma Factor AlgT Represses Pseudomonas aeruginosa Flagellum Biosynthesis by Inhibiting Expression of fleQ. J. Bacteriol. 187:7955-7962. 34. D. J. Wozniak, K.D. Jackson, L. Ma, Y. Sanchez, M. Starkey, R. Landry, J. Hupp, and M.R. Parsek. 2005. The psl-encoded exopolysaccharide is required for cell-cell and cell-surface interactions: implications for understanding early events of P. aeruginosa biofilm development in CF. Pediatric Pulmonology, S6.3, 117-118. 33. D. M. Ramsey and D. J. Wozniak. 2005. Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis. Mol. Microbiol., 56:309-322. 32. D. M. Ramsey, P. J. Baynham, and D. J. Wozniak. 2005. Binding of Pseudomonas aeruginosa AlgZ to sites upstream of the algZ promoter leads to repression of transcription. J. Bacteriol. 187:4430-4443. 31. M. Mishra, G. Parise, K. Jackson, D.J. Wozniak, and R. Deora. 2005. The BvgAS signal transduction system regulates biofilm development in Bordetella. J. Bacteriol., 187:1474-1484. 30. L. M. Cobb, J.C. Mychaleckyj, D.J. Wozniak, and Y.S. Lopez-Boado. 2004. Pseudomonas aeruginosa flagellin and alginate elicit very distinct gene expression patterns in airway epithelial cells: Implications for cystic fibrosis disease. J. Immunol. 173:5659-5670. 29. K. Jackson, M. Starkey, S. Kremer, M.R. Parsek, and D.J. Wozniak. 2004. Identification of psl, a locus encoding a potential exopolysaccharide that is essential for Pseudomonas aeruginosa PAO1 biofilm formation. J. Bacteriol. 186:4466-4475. 28. R. Keyser and D.J. Wozniak. 2004. Effects of sub-inhibitory concentrations of macrolide antibiotics on Pseudomonas aeruginosa. Chest. 125:62S-69S. 27. K. Jackson, R. Keyser, and D.J. Wozniak, 2003. The role of biofilms in airway disease. Sem. Resp. Crit. Care Med. 24:663-670. 26. D. J. Wozniak, A. Sprinkle, and P.J. Baynham, 2003. Control of Pseudomonas aeruginosa algZ expression by the alternative sigma factor AlgT. J. Bacteriol. 185:7297-7300. 25. D.J. Wozniak., T.J.O.Wyckoff, M. Starkey, R. Keyser, P. Azadi, G. O’Toole and. M. Parsek. 2003 Alginate is not a significant component of the extracellular polysaccharide matrix of Pseudomonas aeruginosa PA14 and PAO1 biofilms. Proc. Natl. Acad. Sci. U.S.A. 100:7907-7912.

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24. Yoon, S.S, R. F. Hennigan, G. M. Hilliard, U. A. Ochsner, K. Parvatiyar, M. C. Kamani, H. Allen, T. DeKievit, P. R. Gardner, U. Schwab, J. J. Rowe, B. H. Iglewski, T. R. McDermott, T. Livinghouse, R. P. Mason, D. J. Wozniak, R. E.W. Hancock, R. C. Boucher and D. J. Hassett, 2002. Development and persistence of anaerobic P. aeruginosa in biofilms: Relevance to pathogenesis and therapy of cystic fibrosis lung disease. Dev. Cell. 3: 593-603. 23. Wyckoff, T.J.O., B. Thomas, D. J. Hassett, and D.J. Wozniak. 2002. Static growth of mucoid Pseudomonas aeruginosa selects for nonmucoid variants that have acquired flagella-dependent motility. Microbiology. 148: 3423-3430. 22. D. J. Hassett, J. Cuppoletti, B. Trapnell, J. J. Rowe, S. S. Yoon, G. M. Hilliard, K. Parvatiyar, M. C. Kamani , D. J. Wozniak, S.-H. Hwang, T. R. McDermott, and U. A. Ochsner. 2002. Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic Fibrosis airways: Rethinking antibiotic treatment strategies and drug targets. Adv. Drug Del. Rev. 54:1425-1443. 21. Whitchurch, C., T. Erova, S. Beatson, J. Sargent, J. Emery, J. Harris, R. Levesque, J. S. Mattick, and D. J. Wozniak. 2002. Phosphorylation of the Pseudomonas aeruginosa response regulator AlgR is essential for type IV fimbriae-mediated twitching motility. J. Bacteriol. 184: 4544-4554. 20. Woolwine, S., Sprinkle, AB, and D.J. Wozniak. 2001. Loss of Pseudomonas aeruginosa PhpA aminopeptidase activity results in increased algD transcription. J. Bacteriol. 183: 4674-4679. 19. Wyckoff, T.J.O., and D.J. Wozniak. 2001. Transcriptional analysis of genes involved in Pseudomonas aeruginosa biofilms. Meth. Enzymology. 336: 144-151. 18. Garrett, E.S., D. Perlegas, and D.J. Wozniak. 1999. Negative control of flagellin synthesis in Pseudomonas aeruginosa is modulated by the alternative sigma factor AlgT (AlgU). J. Bacteriol. 181: 7401-7404. 17. Baynham, P.J., A.L. Brown, L.L. Hall, and D.J. Wozniak. 1999. Pseudomonas aeruginosa AlgZ, a ribbon-helix-helix DNA binding protein, is essential for alginate synthesis and algD transcriptional activation. Mol. Microbiol. 33: 1069-1080. 16. Woolwine, S., and D.J. Wozniak. 1999. Identification of an Escherichia coli pepA homolog and its involvement in suppression of the algB phenotype in mucoid Pseudomonas aeruginosa. J. Bacteriol. 181: 107-116.

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15. Ma, S., U. Selvaraj, R. Quarless, D.J. Hassett, D. E. Ohman, and D.J. Wozniak. 1998. Phosphorylation-Independent activity of the Pseudomonas aeruginosa response regulators AlgB and AlgR in promoting alginate biosynthesis. J. Bacteriol. 180: 956-968. 14. S. Ma, D.J. Wozniak, and D.E. Ohman. 1997 Identification of the histidine protein kinase KinB in Pseudomonas aeruginosa and its phosphorylation of the alginate regulator AlgB. J. Biol. Chem. 272: 17952-17960. 13. Richardson, S.H., and D.J. Wozniak. 1996. An ace up the sleeve of the cholera bacterium: A bacteriophage mediates the horizontal transfer of virulence genes between Vibrio cholerae with broad implications for the emergence of pathogenic strains. Nature Medicine (News and Views). 2: 853-855. 12. Baynham, P.J., and D.J. Wozniak. 1996. Identification and characterization of AlgZ, an AlgT-dependent DNA binding protein required for Pseudomonas aeruginosa algD transcription. Mol Microbiol. 22:97-108. 11. Wozniak, D.J., X.Y. Han, and D.R. Galloway. 1995. Construction of a nontoxigenic strain of Pseudomonas aeruginosa for the production of recombinant exotoxin A. Appl. Env. Microbiol. 61:1739-1744. 10. Walker, S.L., L.S. Hiremath, D.J. Wozniak, and D.R. Galloway. 1994. ToxR-Mediated in vitro Transcription of Pseudomonas aeruginosa toxA. Gene. 150: 87-92. 9. Wozniak, D.J., and D.E. Ohman. 1994. Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT. J. Bacteriol. 176: 6007-6014. 8. Wozniak, D.J. 1994. Integration host factor and sequences 3’ of the Pseudomonas aeruginosa algD transcriptional start site are required for expression. J. Bacteriol. 176:5068-5076. 7. Hassett, D.J., W. Woodruff, D.J. Wozniak, M. L. Vasil, M.S. Cohen, and D.E. Ohman. 1993. Cloning and Characterization of the Pseudomonas aeruginosa sodA and sodB Genes Encoding Iron- and Manganese Cofactored Superoxide Dismutase: Demonstration of increased manganese superoxide dismutase activity in alginate-producing bacteria. J. Bacteriol. 175:7658-7665. 6. Ofek, I., K. Kabha, A. Athamna, G.Frankel, D.J. Wozniak, D.L. Hasty, and D.E. Ohman. 1993. Conjugal Transfer of Genetic Determinants for Capsular Polysaccharide Biosynthesis Between Klebsiella pneumoniae Strains of Serotypes K2 and K21a. Infect. Immun. 61:4208-4216

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5. Wozniak, D.J., and D.E. Ohman. 1993. Involvement of the Alginate algT Gene and Integration Host Factor in the Regulation of the Pseudomonas aeruginosa algB Gene. J. Bacteriol. 175:4145-4153. 4. Wozniak, D.J., and D.E. Ohman. 1991. Pseudomonas aeruginosa AlgB, a Two-Component Response Regulator of the NtrC-family, is Required for algD Transcription. J. Bacteriol. 173:1406-1413. 3. Galloway, D.R., R.C. Hedstrom, J.L. McGowan, S.P. Kessler, and D.J. Wozniak. 1989. Biochemical Analysis of CRM 66. J. Biol. Chem. 264:14869-14873. 2. Wozniak, D.J., L.H. Hsu, and D.R. Galloway. 1988. His 426 of the Pseudomonas aeruginosa Exotoxin A is Required for ADP-Ribosylation of Elongation Factor II. Proc. Natl. Acad. Sci. USA. 85:8880-8884. 1. Wozniak, D.J., D.C. Cram, C.J. Daniels, and D.R. Galloway. 1987. Nucleotide Sequence and Characterization of toxR: a Gene Involved in Exotoxin A Regulation in Pseudomonas aeruginosa. Nucleic Acids Research. 15:2123-2135.

Book Chapters: Tart, A. H., and D. J. Wozniak. 2008. Shifting paradigms in Pseudomonas aeruginosa biofilm research. In “Bacterial Biofilms”, vol. 322, T. Romeo, ed. Springer, Heidelberg, Germany. p. 193-206. Ohman, D.E., K.M. Mathee, C.J. McPherson, C.A. Devries, S. Ma, D.J. Wozniak, and M.J. Franklin. Regulation of the alginate (algD) operon in Pseudomonas aeruginosa. In: “Molecular Biology of Pseudomonas”. T. Nakazawa, K. Furukawa, D. Haas, and S. Silver, eds. ASM Press, Washington, DC, p. 472-483. Shumard, C.M., D.J. Wozniak, and D.R. Galloway. 1993. Regulation of Toxin A Synthesis in Pseudomonas aeruginosa. In: “Pseudomonas aeruginosa as an Opportunistic Pathogen”. H. Freidman, M. Bendinelli and M. Campa, eds. Plenum Press, New York, p. 107-121. INVITED PRESENTATIONS (Since 1998):

• 1998, University of Queensland, Brisbane Australia. The response regulator AlgR controls both twitching motility and alginate synthesis in Pseudomonas aeruginosa.

• 1999, American Society for Microbiology National Meeting. "Signal Dependent Control

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of Bacterial Virulence." Coordinate control of motility and alginate synthesis in Pseudomonas aeruginosa. Chicago, IL.

• 2000, International conference on biological response modification of macrolides. The clinical applications of macrolides in the new millenium. Macrolide treatment for the control of Pseudomonas aeruginosa biofilm formation in cystic fibrosis and diffuse panbronchiolitis. Seville, Spain. Sponsored by Dainabot Co., LTD.

• 2000, Montana State University and Center for Biofilm Research. Coordinate control of motility and alginate synthesis in Pseudomonas aeruginosa: implications for understanding biofilm development.

• 2000, University of Kent at Canterbury, UK. Motility and alginate production in Pseudomonas aeruginosa.

• 2000, Florida International University. Inverse relationship of motility and alginate production in mucoid Pseudomonas aeruginosa.

• 2001, Abbott Laboratories. Non ribosomal effects of clarithromycin treatment on Pseudomonas aeruginosa infections.

• 2001, American Society for Microbiology North Carolina State Meeting, Coordinate control of motility and polysaccharide synthesis in the cystic fibrosis pathogen Pseudomonas aeruginosa.

• 2001, North Carolina State University, Genetics and regulation of Pseudomonas aeruginosa polysaccharides.

• 2002, East Carolina University School Medicine. Genetics and regulation of Pseudomonas aeruginosa polysaccharides.

• 2002, Ohio State University. Pseudomonas aeruginosa polysaccharide genetics and regulation in biofilms and CF airway infections

• 2002, American College of Chest Physicians Annual Meeting. San Diego, CA. Effects of macrolides on biofilm formation in Pseudomonas aeruginosa.

• 2003, State University of New York, Buffalo, Buffalo, NY. Regulation of alginate production in mucoid Pseudomonas aeruginosa.

• 2003, Northwestern University, Chicago, IL. Polysaccharide genetics and regulation in P. aeruginosa biofilms.

• 2003, University of Iowa, Iowa City, IA. Role of exopolysacchardies in Pseudomonas aeruginosa biofilm development.

• 2003, American College of Chest Physicians Annual Meeting. Orlando, FL. Effects of macrolides on biofilm formation and bacterial pathogenesis.

• 2003, University of Kentucky, Lexington, KY. Role of exopolysacchardies in Pseudomonas aeruginosa biofilm development.

• 2004, North Carolina State University, Raleigh, NC. The matrix of Pseudomonas aeruginosa biofilms.

• 2004, Cystic Fibrosis Foundation’s annual Williamsburg Conference. Pseudomonas aeruginosa biofilms.

• 2004, 12th Biennial UA-UC Conference on Infectious Diseases, Banff, Alberta Canada. The matrix of Pseudomonas aeruginosa biofilms.

• 2004, Wake Forest University, Department of Biology. Pseudomonas aeruginosa

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infections in cystic fibrosis: an unusual host-pathogen interaction. • 2005, North American Cystic Fibrosis Conference. Baltimore, MD. The psl-encoded

Exopolysaccharide Is Required for Cell-Cell and Cell-surface Interactions: Implications for Understanding Early Events of P. aeruginosa Biofilm Development in CF.

• 2006, North Carolina State University. Raleigh, NC. The psl-encoded Exopolysaccharide Is Required for Cell-Cell and Cell-surface Interactions: Implications for Understanding Early Events of P. aeruginosa Biofilm Development in CF

• 2006, FASEB Summer Research Conference, Tucson AZ. Symposium organizer and speaker. The matrix of Pseudomonas aeruginosa biofilms.

• 2006, Ohio State University Seminar Series. Polysaccharides of Pseudomonas aeruginosa biofilms.

• 2006, Marshall University Seminar Series. Coordinate control of virulence gene expression in Pseudomonas aeruginosa.

• 2006, North Carolina bacterial pathogenesis Meeting. Chapel Hill, NC. Pseudomonas aeruginosa biofilms. Matrix Revisited.

• 2006, Medical College of Virginia Seminar Series. Richmond, VA. Pseudomonas aeruginosa biofilms. Matrix Revisited.

• 2006, West Virginia University College of Medicine Seminar Series. Morgantown, WV. Polysaccharides of Pseudomonas aeruginosa biofilms.

• 2007, University of Washington Microbiology Seminar Series. Seattle, WA, The Pseudomonas aeruginosa biofilm matrix.

• 2007, University of Iowa College of Medicine Seminar Series. Iowa City, IA. The matrix of Pseudomonas aeruginosa biofilms.

• 2007, Pseudomonas 2007. Seattle, WA. Invited plenary speaker. Polysaccharides of Pseudomonas aeruginosa biofilms.

• 2007, Appalachian State University Seminar Series. Boone, NC. Biofilms of Pseudomonas aeruginosa.

• 2007, Virginia Polytechnic Institute Seminar Series. Blacksburg, VA. Polysaccharides of Pseudomonas aeruginosa biofilms

• 2008, ASM Committee for Undergraduate Education Meeting. Beverly, MA. P. aeruginosa biofilms in cystic fibrosis

• 2008, FASEB Summer Research Conference, Carefree AZ. Invited speaker. The matrix of Pseudomonas aeruginosa biofilms.

• 2008, 5th Annual Center for Microbial Interface Biology Retreat, The Ohio State University. Evolution of Pseudomonas aeruginosa in the CF airway.

• 2008, Ohio State University Division of Infectious Disease, Bad bugs, no drugs. Are vaccines a potential solution?

• 2009, Kenyon College Seminar Series. Gambier, OH. The anatomy of a bacterial biofilm.

• 2009, University of Texas, Houston Seminar Series. Evolution of Pseudomonas aeruginosa in the CF airway.

• 2009, ASM Biofilms 2009. Invited speaker. The matrix of Pseudomonas aeruginosa biofilms.

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Appendix C

GRADUATE STUDENTS/RESIDENTS/FELLOWS ADVISED:

Current

• Luyan Ma, Ph.D., Postdoctoral fellow; Source of support: CFF fellowship grant MA06F0 • Elizabeth Waligora, Ph.D. candidate; Source of stipend support: AHA predoctoral fellowship • Cynthia Ryder, Graduate student: Source of stipend support R01AI061396 • Matthew Byrd, Graduate student: Source of stipend support NIH F31AI078700, Ruth L.

Kirschstein NRSA

Previous

• Andrea Rockel, Graduate student, funding by NIH grant R01HL58334. Current: Instructor, Guilford College, Greensboro, NC.

• Belen Belete, Graduate student, funding by NIH grant R01HL58334. Current: Assistant Professor, Winston Salem State University, Winston Salem, NC.

• Deborah Ramsey, Graduate student and postdoctoral fellow, funding by NIH grant R01HL58334 and American Heart Association Fellowship 0215191U. Current: Postdoctoral fellow, Washington University School of Medicine, St. Louis, MO.

• Kara Jackson, Graduate student, funded by Lucille & David Packard Research Grant. Current: Research Edit Specialist, NC A&T University.

• Anne Tart, Ph.D. Graduate student, funded by AHA 0515325U fellowship and NIH grant R01HL58334. Current: Postdoctoral fellow, Methodist Hospital Research Institute.

• Tanya Erova, Ph.D. (postdoctoral fellow), funded by a Cystic Fibrosis Foundation postdoctoral fellowship. Current: Research Associate, University of Texas, Galveston.

• Patricia Baynham, Ph.D. (graduate student/postdoctoral fellow), funded by NIH grant R01 HL59334 and R29 AI35177, Current: Assistant Professor of Biology, St. Edward's University, Austin, TX.

• Samuel Woolwine, Ph.D. (graduate student), funded by NIH grant R01 HL59334 and R29 AI35177, Current: Biotechnology Patent Specialist, Baltimore, MD

• Timna Wyckoff, Ph.D. (postdoctoral fellow), funded by NIH R01grant AI25779, Current: Assistant Professor of Biology, University of Minnesota, Morris.

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Appendix C

Curriculum Vitae

Mark E. Drew

Assistant Professor Ohio State University College of Medicine

Division of Infectious Diseases

Contact Information: Email: [email protected]

Address: Division of Infectious Diseases The Ohio State University Medical Center

Biomedical Research Tower, Rm. 1020 460 W. 12th Ave.

Columbus, OH 43210 Phone: 614-247-5337

Fax: 614-292-9616

Training and Education Post-Doctoral Research Associate Dr. Daniel Goldberg, Howard Hughes Medical Institute 06/02 – 08/08 Ph.D., Department of Biological Chemistry Johns Hopkins University School of Medicine 2002 Research Technician Dr. Scott Landfear, Oregon Health Sciences University 11/94 – 6/96 Research Technician Dr. Jean Feagin, Seattle Biomedical Research Institute 6/91 – 10/94 B.A., Department of Chemistry Seattle Pacific University 1991

Teaching Experience Course Faculty, Biology of Parasitism, Marine Biological Laboratories, Woods Hole, MA. Summer 2008 Teaching Assistant to Dr. Daniel Goldberg, Biology of Parasitism, Marine Biological Laboratories, Woods Hole, MA. Summer, 2006 and 2007

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Course Assistant and Lecturer – Fundamentals of Light Microscopy, Johns Hopkins University School of Medicine. 1999 – 2001. Teaching Assistant to Dr. Jean Feagin, Biology of Parasitism, Marine Biological Laboratories, Woods Hole, MA. Summer, 1994 and 1995

Scholarships/Awards Student Scholarship – Keystone meeting “RNAi, co-suppression and related phenomena”. Taos, NM 2002

Publications Drew ME, Banerjee R, Gilbertson SR, Rosenthal PJ, Goldberg DE. Plasmodium food vacuole plasmepsins are activated by falcipains, J. Biol. Chem. 2008 May 9;283(19):12870-6 Motyka SA, Drew ME, Yildirir G, Englund PT. Overexpression of a cytochrome b5 reductase-like protein causes kinetoplast DNA loss in Trypanosoma brucei. J. Biol. Chem. 2006 Jul 7;281(27):18499-506 Liu J, Gluzman I, Drew ME, Goldberg DE. The Role of Plasmodium falciparum Food Vacuole Plasmepsins. J. Biol. Chem., Jan 2005; 280: 1432 – 1437 Drew, ME, Motyka, SA, Morris, JC, Wang, Z, Englund, PT. Inducible RNAi as a Forward Genetic Tool in Trypanosoma brucei. In: Appasani, K, editor. RNA Interference Technology. Cambridge University Press. 2005 Morris, JC, Wang, Z, Motyka, SA, Drew, ME, Englund, PT. An RNAi-based genomic library for forward genetics in the African trypanosome. In: Sohail, M, editor. Gene Silencing by RNA Interference: Technology and Application. Boca Raton: CRC Press LLC. 2004 Drew ME*, Wang Z*, Morris JC* (*co-first authors), Wells L, Sanchez M, Landfear SM, Englund PT. The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library. J. Biol. Chem. 2003 Nov 21;278(47):46596-60 Wang Z, Drew ME, Morris JC, Englund PT. Asymmetrical division of the kinetoplast DNA network of the trypanosome. EMBO J. 2002 Sep 16;21(18):4998-5005 Morris JC*, Wang Z*, Drew ME*, (*co-first authors) Englund PT. Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library. EMBO J. 2002 Sep 2;21(17):4429-38

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Grahms J, Morris JC, Drew ME, Wang Z, Englund PT, Hajduk SL. Transcription and Replication Priming of Kinetoplast DNA Maxicircles by a Mitochondrial RNA Polymerase. J. Biol. Chem. 2002 May 10;277(19):16950-9. Klingbeil MM, Drew ME, Liu Y, Morris JC, Motyka SA, Saxowsky TT, Wang Z, Englund PT. Unlocking the Secrets of Trypanosome Kinetoplast DNA Network Replication. Protist, December 2001, vol. 152, no. 4, pp. 255-262(8) Wang Z*, Morris JC*, Drew ME*, Paul KS*, (*co-first authors) Englund PT. Inhibition of Bloodstream Form Trypanosoma brucei Gene Expression by RNA Interference Using the pZJM Dual T7 Vector. Mol. Biochem. Parasitol. 2001 Sept. 28; 117(1):111-113 Drew ME, Englund PT. Intramitochondrial location and dynamics of Crithidia fasciculata kinetoplast minicircle replication intermediates. J. Cell. Biol. 2001 May 14;153(4):735-44 Abu-Elneel K, Robinson DR, Drew ME, Englund PT, Shlomai J. Intramitochondrial localization of universal minicircle sequence-binding protein, a trypanosomatid protein that binds kinetoplast minicircle replication origins. J. Cell. Biol. 2001 May 14;153(4):725-34 Morris JC, Drew ME, Klingbeil MM, Motyka SA, Saxowsky TT, Wang Z, Englund PT. Replication of kinetoplast DNA: an update for the new millennium. Int. J. Parasitol. 2001 May;31(5-6):453-8 Wang Z*, Morris JC*, Drew ME* (*co-first authors), Englund PT. Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. J. Biol. Chem. 2000 Dec 22;275(51):40174-9 Carter NS, Drew ME, Sanchez M, Vasudevan G, Landfear SM, Ullman B. Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant. J. Biol. Chem. 2000 Jul 7;275(27):20935-41 Vasudevan G, Carter NS, Drew ME, Beverley SM, Sanchez MA, Seyfang A, Ullman B, Landfear SM. Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant. Proc. Natl. Acad. Sci. U S A. 1998 Aug 18;95(17):9873-8 Klamo EM, Drew ME, Landfear SM, Kavanaugh MP. Kinetics and stoichiometry of a proton/myo-inositol cotransporter. J. Biol. Chem. 1996 Jun 21;271(25):14937-43 Drew ME, Langford CK, Klamo EM, Russell DG, Kavanaugh MP, Landfear SM. Functional expression of a myo-inositol/H+ symporter from Leishmania donovani. Mol. Cell. Biol. 1995 Oct;15(10):5508-15

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Langford CK, Kavanaugh MP, Stenberg PE, Drew ME, Zhang W, Landfear SM. Functional expression and subcellular localization of a high-Km hexose transporter from Leishmania donovani. Biochemistry. 1995 Sep 19;34(37):11814-21 Feagin JE, Drew ME. Plasmodium falciparum: alterations in organelle transcript abundance during the erythrocytic cycle. Exp. Parasitol. 1995 May;80(3):430-40

Talks/Posters Drew ME, Goldberg DE. Falcipains activate the P. falciparum plasmepsins. Molecular Parasitology Meeting, Woods Hole, MA 2007 (talk) Arastu-Kupur S, Verhelst S, Drew ME, Fonovic M, Phillips C, Goldberg DE, Powers J, Bogyo M. Probing Serine Protease Function in the Human Malaria Parasite Plasmodium falciparum. Molecular Parasitology Meeting, Woods Hole, MA 2005 (talk) Drew ME, Oksman A, Wood W, Ellman J, Goldberg DE. Discovery of probes for the cysteine proteases involved in Plasmodium falciparum egress through in vivo screening of a mechanism-based inhibitor library. Molecular Parasitology Meeting, Woods Hole, MA 2004 (talk) Drew ME, Morris JC, Wang Z, Sanchez M, Landfear SM, Englund PT. Generation of Tubercidin Resistant T. brucei using an RNAi Library. Molecular Parasitology Meeting, Woods Hole, MA 2001. (talk) Drew ME, Englund PT. The Birefringent Kinetoplast of Crithidia fasciculata: Visualization in Living Cells by Polarized Light Microscopy. Molecular Parasitology Meeting, Woods Hole, MA 2000. (poster) Drew ME, Englund PT. Spatial and Temporal Characterization of Crithidia fasciculata Minicircle Replication Intermediates. Molecular Parasitology Meeting, Woods Hole, MA 1999. (talk) Drew ME, Englund PT. A Novel Site for kDNA Minicircle Replication in Crithidia fasciculata. Molecular Parasitology Meeting, Woods Hole, MA 1998. (talk) Morris JC, Li C, Drew ME, Englund PT. Cloning and Characterization if a Mitochondrial DNA Primase from Crithidia fasciculata. Molecular Parasitology Meeting, Woods Hole, MA 1998. (talk) Vasudevan G, Carter N, Drew M, Beverley SM, Sanchez MA, Seyfang A, Ullman B, Landfear S. Cloning the Leishmania donovani adenosine/pyrimidine nucleoside transporter gene by functional complementation. Molecular Parasitology Meeting, Woods Hole, MA 1998. (talk)

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Carter N, Drew M, Vasudevan G, Beverley SM, Ullman B, Landfear S. Molecular Cloning of the Inosine-Guanosine Transporter from Leishmania donovani. Molecular Parasitology Meeting, Woods Hole, MA 1997. (talk) Vasudevan G, Drew M, Carter N, Beverley SM, Ullman B, Landfear S. Cloning the Leishmania donovani Adenosine-Pyrimidine Nucleoside Transporter by Genetic Complementation. Molecular Parasitology Meeting, Woods Hole, MA 1997. (talk) Landfear SM, Drew ME, Langford CK, Russell DG. Functional Expression of a myo-Inositol Transporter from Leishmania donovani Molecular Parasitology Meeting, Woods Hole, MA 1995. (talk)

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Appendix C

Rebecca B. Garabed, VMD MPVM

Department of Preventive Medicine

College of Veterinary Medicine

The Ohio State University Phone: 614-247-1842

Sisson Hall, 1920 Coffey Road Fax: 614-292-4142

Columbus, OH 43210 Email: [email protected]

Education:

Ph.D. (Epidemiology)

University of California Davis, Davis, CA – 2008

M.P.V.M. (Master of Preventive Veterinary Medicine)

University of California Davis, Davis, CA – 2005

V.M.D. (Veterinary Medical Doctorate)

University of Pennsylvania, Philadelphia, PA – 2003

B.S. Animal Biosciences with Honors in Veterinary Science

Penn State University, University Park, PA – 1999

Additional Educational Experience:

CDC Externship – Investigation of an outbreak of Legionnaires Disease – June/ July 2002, Atlanta, GA (outbreak in Montgomery County, PA)

Risk Analysis Externship – Risk analysis of Bovine Viral Diarrhea in veal calves – spring 2002, Veterinary Laboratories Agency, UK

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Governmental Relations Externship – American Veterinary Medical Association training in public policy and lobbying – spring 2002, Washington, D.C.

USDA Externship – Training in the types and uses of diagnostic tests – spring 2002, Ames, IA

NIH Summer Research Grant – Research on Salmonella in Swiss swine conducted with the Swiss Federal Veterinary Office – summer 2001, Bern, Switzerland

Short Course in Epidemiology – University of Bern, Switzerland – July 2001

Schreyer Ambassador Grant for Travel – Molecular biology research at the Free University in Berlin, Germany – 1998

Teaching Experience: (Guest Lecturer) Prevention of Communicable Diseases (VPM 796.02) – The Ohio State

University, College of Veterinary Medicine, Fall 2008 (Co-Taught) Bayesian Models and Methods for Diagnostic Screening – XI International

Symposium on Veterinary Epidemiology and Economics (ISVEE), August 13 - 15, 2006, Cairns, Australia (Co-Taught) Software for Epidemiology (EPI 298) University of California, Davis, Fall 2005 – Spring

2006

(Teaching Assistant) Statistical Models, Methods and Data Analysis for Scientists (EPI 204) – University of California, Davis, Spring 2005

(Teaching Assistant) Introductory Animal Science (AnSci 001) – Penn State University, Spring 1999

Professional Experience:

Assistant Professor – 2008 to present (Department of Preventive Medicine, College of Veterinary Medicine, The Ohio State University)

Graduate Student Researcher – Epidemiology research in statistical and genetic models for foot-and-mouth disease on a global scale —2003 to 2008 (Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA)

Associate Veterinarian – Practicing small animal veterinarian —May to July 2003 (Conchester Animal Hospital, Boothwyn, PA)

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Pathology Technician – Large animal post-mortem room assistance – November 1999 to March 2002 (Department of Pathobiology, University of Pennsylvania, New Bolton Center, Kennett Square, PA)

Licenses and Certificates:

Ohio Veterinary License – received 2009

California Veterinary License – received 2005

Pennsylvania Veterinary License – received 2003

Humane Society Disaster Response Certification – received 2001

Presentations:

R.B. Garabed, W.O. Johnson, A.M. Perez, and M.C. Thurmond. Factors influencing global FMD reporting and risk. Session of the Research Group of European Commission for Foot and Mouth Disease Control Report, Erice, Italy, October 2008.

R.B. Garabed, A.M. Perez, W.O. Johnson, and M.C. Thurmond. The use and limitations of expert opinion data for foot-and-mouth disease surveillance. American Association of Veterinary Laboratory Diagnosticians, Reno, NV, October 2007.

R.B. Garabed, W.O. Johnson, A.M. Perez, and M.C. Thurmond. A high-resolution global hierarchical Bayesian model to predict foot-and-mouth disease presence. American Association of Veterinary Laboratory Diagnosticians, Reno, NV, October 2007.

R. B. Garabed, A. M. Perez, N. Knowles, and M. C. Thurmond. Visualizing genetic signatures associated with host factors in FMDV using GIS technology. International Symposium on Veterinary Epidemiology and Economics, Cairns, Australia, August 2006.

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R. B. Garabed, A. M. Perez, W. O. Johnson, and M. C. Thurmond. Predictive modeling as a tool for global foot-and-mouth disease surveillance. International Symposium on Veterinary Epidemiology and Economics, Cairns, Australia, August 2006.

R. B. Garabed, A. M. Perez, W. O. Johnson, and M. C. Thurmond. A hierarchical global foot-and-mouth disease prediction model. Canadian Association of Veterinary Epidemiology and Preventive Medicine, Saskatoon, Saskatchewan, June 2005.

A. M. Perez, R. B. Garabed, and M. C. Thurmond. Continental and inter-continental time - space clusters of variation in genetic distance of complete sequences for FMD type O strains (1939-2001). Canadian Association of Veterinary Epidemiology and Preventive Medicine, Saskatoon, Saskatchewan, June 2005.

R. B. Garabed, M. C. Thurmond, W. O. Johnson, and T. E. Carpenter. Exploring the relationships of political and economic factors to national FMD status on a global scale. Conference of Research Workers in Animal Diseases, Chicago, Illinois, November 2004.

Perez A, Thurmond M, Johnson W, Carpenter T, Grant P, Garabed R, Melbourne B, Choi Y, Branscum A, Benning L, Bates T, Lynch C, Eidson M, Ascher M, Gotham I, Chen H. The BioPortal information system for foot-and-mouth disease surveillance. United States Animal Health Association/ American Association of Veterinary Laboratory Diagnosticians meeting. Greensboro, North Carolina, October 2004.

Perez A, Thurmond M, Carpenter T, Bates T, Johnson W, Melbourne B, Aslam S, Garabed R, Choi Y, Branscum A, Gallego M, Grant P. Epidemiological models for global surveillance of foot-and-mouth disease. United States Animal Health Association/ American Association of Veterinary Laboratory Diagnosticians meeting. Greensboro, North Carolina, October 2004.

Perez AM, Thurmond MC, Carpenter TE, Bates TW, Johnson WO, Melbourne BA, Aslam S, Garabed R, Choy Y, Branscum AJ, Gallego ML, Grant PW. Epidemiological models for global

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surveillance of foot-and-mouth disease. Session of the Research Group of European Commission for Foot and Mouth Disease Control (EUFMD). October 2004. Chania, Greece.

Theses:

Micro and Macro Approaches to the Analytical Epidemiology of Foot-and-Mouth Disease. submitted for PhD degree, University of California, Davis, March 2008.

Relationships of Political and Economic Factors to National FMD Status on a Global Scale. submitted for MPVM degree, University of California, Davis, August 2004.

The Effects of Selenium Status on the Expression of Cyclooxygenase-1 and Cyclooxygenase-2. submitted for BS degree, Penn State University, August 1999.

Research in progress:

R.B. Garabed, A.M. Perez, and M.C. Thurmond. Evaluation of the Use of Expert Opinion for the Prediction of Foot-and-Mouth Disease (manuscript in revision for PVM, December 2008)

R.B. Garabed, W.O. Johnson, and M.C. Thurmond. Global High-Resolution Prediction of Background Foot-and-Mouth-Disease Risk (manuscript in preparation)

Publications:

R.B. Garabed, W.O. Johnson, and M.C. Thurmond. (2009). Analytical epidemiology of genomic variation among pan Asia strains of foot-and-mouth disease virus, Transboundary and Emerging Diseases. 56: 142–156. R.B. Garabed, W.O. Johnson, J. Gill, A.M. Perez, and M.C. Thurmond. (2008). Exploration of associations between governance and economics and country level foot-and-mouth disease status

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by using Bayesian model averaging, Journal of the Royal Statistical Society (Series A). 171(3): 699–722.

G.O. Kelley, R.B. Garabed, A. Branscum, A.M. Perez, and M.C. Thurmond. (2007). Prediction model for sequence variation of the glycoprotein gene of infectious hematopoietic necrosis virus in California, U.S.A., Diseases of Aquatic Organisms. 78: 97-104.

H.K. Mineo and R. B. Garabed. (2007). Evaluation of a bench-top coagulation analyzer for measurement of prothrombin time, activated partial thromboplastin time, and fibrinogen concentrations in healthy dogs, American Journal of Veterinary Research. 68(12): 1342-1347.

Awards:

Graduate Student Support Fellowship – U.C. D., Veterinary Medical Dean’s Office (2004-2007)

Block Grant – University of California, Davis, Graduate Group in Epidemiology (2003-2004)

Travel Grant – University of California, Davis, Graduate Student Association (Summer 2006)

Summer Research Grant – National Institutes of Health/ Univ. Pennsylvania (Summer 2001)

Schreyer Ambassador Grant – Penn State University (Summer 1998)

Professional Organization Memberships:

Ohio Veterinary Medical Association

American Veterinary Medical Association

American Association of Veterinary Laboratory Diagnosticians

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Appendix D

International Congress in Infectious Diseases – Meeting the Infectious Diseases Challenges of the 21st Century

White Paper

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Appendix D

PHPID International Congress White Paper Draft

Proposed Congress Title: Meeting the Infectious Disease Challenges of the 21st Century

The Ohio State University is an ideal host for an International Congress on Public Health

Preparedness and Infectious Diseases. Our faculty has expertise across a broad spectrum of

topics and our unique interdisciplinary approaches to infectious disease research are increasing

the translational nature of academic programs. By hosting this congress (which we envision will

take place in 2011), the intercollegiate research achievements occurring across our campuses will

gain broader national and international exposure, demonstrating that the PHPID has indeed

proved a successful model as our infectious disease and public health preparedness research is

moving from excellence to eminence.

Goals

Based on the charge from the PHPID Steering Committee and the ideas of the International

Congress Committee, the goals of the proposed Congress are to accelerate advancement in

preventing, controlling and conquering globally important infectious diseases and to encourage

the development of creative and effective approaches to meeting the challenges of public health

preparedness issues.

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Priority Topics and Format of Congress

The committee identified several priority areas that should be covered in this international

congress. Identification of these areas was based on two main criteria: the global significance of

the issue and the strength of the PHPID in the specific area. Based on these criteria, the

committee identified six priority areas:

1. Clinical HIV medicine and basic retroviral research;

2. Zoonotic and vector-borne diseases;

3. Intracellular pathogens (particularly tuberculosis);

4. Drug-resistant bacterial infections;

5. Host-pathogen interaction and immunology;

6. Threats to food and water safety.

The committee envisions that the meeting sessions should focus on 5-6 major themes, with 2

themes being covered each day. Thus, we expect that the Congress will be a three-day event.

PHPID areas of strength will be showcased within the theme areas. Following each set of talks,

a panel discussion will occur. Specific topics/speakers will be selected by content area experts.

Speakers will be asked to focus on their novel approaches that could be broadly applicable to

other infectious diseases. For example, a talk could discuss how TB epidemiological data is

collected and analyzed, with an eye on how such techniques could be used in the case of malaria

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or HIV. When relevant, a discussion of developed vs. less developed world issues could take

place. More general poster sessions could be held daily to provide the maximum number of

researchers an opportunity to showcase their work. The committee feels that this approach will

attract the largest audience and allow the Congress to fill a unique niche. Thus, the Congress

could serve to advance the field of infectious disease research, control and prevention by

exposing attendees to current best practices.

Six possible theme areas are as follows: 1) Pathogenesis (virulence factors, infectivity pathways,

mechanisms of disease); 2) Epidemiology (monitoring and analysis techniques, data application);

3) Diagnostic issues (including developed and less developed world issues); 4) Transmission

prevention (mechanisms for discovering modes of transmission, vaccines, education efforts,

environmental interventions, molecular-to-population scale infectious disease modeling); 5)

Drug discovery and development (target validation, target identification, academic vs. industrial

efforts); 6) Modeling economic impact from infectious diseases (socio-political factors, short-

term and long-term community-country-continent-global effects); 7) Public health preparedness

(policy drivers and implications, crossing borders issues, patent laws, access issues). Each day

of the three-day conference will focus on two of the theme areas.

This Congress (proposed to be held at the Columbus Convention Center) will include basic

infectious disease research, while simultaneously emphasizing the translational importance of

such knowledge. As such, Key Note speakers for each topic from leading infectious disease

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researchers from around the globe will share their latest research findings organized by approach

as outlined above. From that a synthesis of such knowledge will then be made by a Panel of

Experts. This synthesis will then culminate with Outreach sessions for healthcare professionals,

preparedness practitioners, and the public concerning current best-practices in critical subject

areas. Selected media coverage of these outreach sessions will be used to disseminate key

information at state, national, or international levels, and a follow-up publication is planned to

summarize the take-home lessons of the congress. The process to take place at the meeting is

represented in the figure below.

Partners

In addition to partnerships at the local, state, and national level, the success of this Congress will

require strong support from the University administration. Some potential partnerships (both at

and outside of the University) could include:

1. OSU - Office of the President, Office of Research, Office of Academic Affairs, and

Office of Communications;

2. OSURF;

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3. Centers and Institutes within OSU such as the Center for Microbial Interface Biology,

Center for Global Health, and the Ohio Agricultural Research Development Center

(OARDC);

4. Ohio Department of Health and Ohio Department of Agriculture;

5. Nationwide Children’s Hospital;

6. Battelle;

7. The Third Frontier initiative from the State of Ohio;

8. NIH, particularly NIAID;

9. CDC, particularly NCID;

10. NSF;

11. FDA;

12. USDA;

13. Trade Groups;

14. The Google Foundation

15. The Bill and Melinda Gates Foundation;

16. The health products industry and the pharmaceutical industry.

Challenges

The following potential challenges were identified:

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1. Funding - To successfully put on the Congress, adequate financial support will be

required. Since a large (1000 or more attendees) meeting is envisioned, we estimate that

$1,000,000 may be needed.

2. Speakers - World class speakers will be invited to draw attendees and give the Congress

impact, and it will be a challenge to secure their participation due to scheduling conflicts.

3. Focus - It will be a challenge to plan a Congress that is sufficiently broad to showcase the

interests of the PHPID program while maintaining an adequate focus capable of drawing

the interest of participants both nationally and internationally.

4. Logistics – Organizing a large meeting will require careful planning (such as allowing a

sufficient amount of time to secure the participation of key speakers, obtaining adequate

facilities, arranging for media coverage, and finding the appropriate time to schedule the

congress). Therefore it is essential to 1) form a scientific committee representing all the

scopes to be covered during the congress 2) form an organizing body particularly

including those with previous experience and 3) subcontract the organizing activities to

professional meeting planning services.

5. Time commitment of the faculty - Organizing this congress will also take precious time

away from the research and teaching efforts of already busy committee members at a

time when it is already extremely difficult to secure and/or maintain research funding.

Therefore, academic units need to be clear of the organizational demands of the congress,

accommodate the time commitments, and give appropriate credit to faculty members who

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volunteer to participate. This will ensure identifying sufficient faculty talent from the

various colleges to develop a successful congress.

Organization

An oversight committee will be responsible for insuring that milestones are reached according to

the timeline below. The aid of professional meeting planners will be enlisted to help in making

critical logistical arrangements (such as booking hotels and meeting halls). Scientific

subcommittees will have the critical responsibility of organizing coherent sessions. For this

purpose, it will be essential to have the participation of committee members who are well-versed

in the subject areas of the scientific or clinical sessions. Appropriate plans must also be made to

publish an abstract book, a conference schedule, and the conference proceedings (this could be

done by obtaining the cooperation of the publisher of a prominent infectious disease journal). In

addition, we anticipate that a funding committee will be needed to ensure that adequate support

for the Congress is obtained.

Deliverables and outcomes:

• Attract attention of federal, state, local, and commercial donors.

• Set of defined papers.

• New collaborations.

• Highlight academic programs across campus.

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• Showcase OSU medical center expansion and OSU in general.

• Forum to educate Ohioans about infectious disease prevention and treatment.

Proposed timeline

12-18 months prior

9-12 months prior

6-9 months prior

3-6 months prior

0-3 months prior

Develop white paper

Make arrangements with convention center and local hotels

Confirm schedule for Keynote sessions

Abstract deadline for participants (5-6 months prior)

Make detailed plans for meals and coffee breaks

Submit white paper for review by PHPID Steering Committee and University

Begin planning detailed scientific program

Begin to engage the media regarding coverage

Reserve hotel blocks for participants

Publish abstract books and conference programs

Obtain commitments from keynote speakers

Send out announcements regarding congress

Confirm participation of sponsors and vendors

Registration deadline for participants (3-4 months prior)

Make logistical arrangements for meeting rooms, poster sessions, and vendor displays

Organize congress committees

Contact sponsors and vendors

Monitor funds secured

Set detailed program


Contract with Meeting Planner

Communicate with Planner







Contact OSU communications regarding media coverage

Solicitation of grant funding

Reserve conference facility and hotel blocks

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Appendix E

2008 Graduate Research Fellowship Awardee Proposal Abstracts

2008 Pilot Research Grant Awardee Proposal Abstracts

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2008 Graduate Research Fellowship Awardee Proposal Abstracts 1. Pankajavally Somanathan Pillai, Smitha (CVM/OARDC/FAHRP) Doctoral advisor: Dr. Chang Won Lee E-mail: [email protected]

Abstract: Viral and host factors involved in the interspecies transmission of avian influenza

The research program for my PhD degree focuses on the viral and host factors involved in the interspecies transmission of wild bird origin low pathogenic avian influenza (LPAI) viruses to land based domestic poultry. Wild aquatic and shore birds are considered to be the global reservoirs of influenza A viruses. These birds serve as source of influenza viruses for domestic birds resulting in varying phenotypes of viral replication, distribution, pathogenicity and transmission. In these birds, the viral genomes can undergo mutations or reassortments with existing viruses to give rise to highly pathogenic avian influenza viruses. Also, these viruses have zoonotic potential and can give rise to global pandemics. In order to prevent an infection in domestic birds, or detect and intervene during the early stages, a thorough understanding of the mechanisms (at the viral and host level) involved in interspecies transmission of influenza viruses from wild aquatic birds is very important. To this end, we undertook the pathobiological characterization of 21 different H5 LPAI isolates of different wild bird origins in three domestic bird species, chickens, ducks and turkeys. It was interesting to note that even genetically identical viruses behaved differently with regard to replication and transmission in these three species. Based on our characterization results, we selected three isolates that included a high and low poultry adapted virus and an isolate that shows preferential replication and transmission in ducks and turkeys, but not in chickens. We will use these isolates to study the genetic basis of interspecies transmission using reverse genetics in combination with in vitro mutagenesis. Along with the viral genetic factors, host biology and genetics play important roles in influenza viral infection, replication, pathogenicity and transmission. The receptors for influenza viruses in the hosts are the terminal sialic acids of glycoproteins and glycolipids. We studied the receptor type (mammalian or avian) and distribution in different organs of the respiratory, digestive, immune and reproductive system of chickens, ducks and turkeys using lectin histochemistry. We identified avian and mammalian type receptors in the trachea of turkeys, which could make them potential mixing vessels, like chickens, pigs and quails, for avian and mammalian influenza viruses. We also identified an abundance of avian type receptors in the oviduct of turkeys that could be responsible for the drastic declines in egg production seen with influenza A virus infections in layer turkeys. Also, the innate immune responses that are elicited after influenza virus

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entry into the hosts influence the viral replication, pathogenicity and transmission patterns. Our research plan encompasses study on the expression of toll like receptors and cytokine and chemokine responses following influenza infections in poultry. We will utilize real-time RT-PCR and mutiplex suspension array technique developed in our lab for the study of innate immune responses following influenza infections in chickens, ducks and turkeys. We plan to accomplish three major goals: 1. Genetic basis of interspecies transmission: We will use reverse genetics to identify the genes and amino acids involved in interspecies transmission of wild bird origin influenza viruses to domestic birds. We have completed sequencing the full length genome of the three viral isolates and cloned individual genes into reverse genetic vectors. Initially, we will focus on the role of individual genes on the observed phenotypes by creating single gene reassortants using reverse genetics. Once the genes responsible for these phenotypes have been identified, we will focus on the role of specific genes using a combination of site directed mutagenesis and reverse genetics, followed by in vitro and in vivo characterization of the selected isolates. 2. Virus- receptor interactions: We studied the receptor type and distribution in different tissues of domestic birds using 2 different lectins (MAA and SNA) that are specific for the avian and mammalian type influenza virus receptors. Though lectin histochemistry gives details about the distribution of receptors, it does not clearly reflect the viral attachment to tissues. We will use solid phase binding assay to demonstrate the actual binding of parent and reassortant viruses to these receptors. We hypothesize that the viral attachment to these receptors is a major determinant of the viral replication and pathogenicities observed. We will use plasma membranes prepared from trachea and intestine to perform the solid phase binding assay. 3. Innate immune responses: The innate immune responses that provide immediate and non-specific immunity to influenza viruses are mediated by cytokines and chemokines that are produced by activation of toll like receptors. We will determine the expression of selected toll like receptors, cytokines and chemokines in respiratory and digestive tract of chickens, ducks and turkeys following infection with influenza viruses. We anticipate that the varying intensity of immune responses observed in these three species will correspond to the different degrees of viral shedding and transmission efficiency observed.

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2008 Graduate Research Fellowship Awardee Proposal Abstracts

2. Jason Marion (CPH) Doctoral Advisor: Tim Buckley E-mail: [email protected]

Abstract: Water quality and related safety of recreational waters throughout Ohio

Research Plan Anticipated During PHPID Fellowship

To address the need for a practical and effective approach for assessing Ohio in-land beach infectious disease risk, we will test the following two strategic hypotheses. 1) The change in trophic state index values at inland lakes is associated with fecal indicator bacteria loads, including E. coli. 2) Increases in trophic state index values will be associated with an increase in adverse health outcomes in exposed populations. In addressing these hypotheses, the primary objective will be to evaluate whether deviation in trophic state index (TSI) is useful in predicting E. coli loads at several of Ohio’s inland lakes. Secondarily, these data will be combined with simultaneously collected 14-day cohort study data to characterize the health status of beach users to determine the relationship between deviations in TSI with health outcomes. Research objectives will be accomplished through three specific aims.

1. Evaluation of beach and surface water quality. Information including E. coli, total phosphorus, chlorophyll A, turbidity, pH, dissolved oxygen, total suspended solids, temperature, lake stage and other water quality data will be collected permitting beach water quality assessment. Water samples will be collected April through November of 2009 and will be evaluated in accordance with Standard Methods for Examination of Water & Wastewater (APHA et al. 2006). E. coli will be cultured and enumerated using EPA method 1603, which uses membrane filtration and modified m-TEC agar. Alternative methods using MacConkey agar will be considered if we are unsuccessful in securing external funding.

2. Calculating trophic state index values. Secchi depth, surface phosphorus and surface chlorophyll A will be used to calculate Carlson’s TSI (Carlson 1977). Each metric (secchi depth, surface phosphorus and chlorophyll A) will be used to calculate a trimetric mean TSI value for each sampling period at each lake. TSI calculation will occur April through November 2009.

3. Characterizing the health status of beach users before and after exposure.

Face-to-face surveys regarding health signs/symptoms and exposure will be performed on weekends and holidays from May through October of 2009 at East Fork State Park. A beach ball will be provided to participants, whom will also be asked to participate in a follow-up phone interview 12 to 14 days later. Consent forms will be signed by all participants and all questionnaires will be approved by the OSU Institutional Review Board prior to use.

Sampling Location and Frequency: Seven inland state park lakes will be sampled weekly. Sampling will be performed in four zones (Zone 1: Deer Creek, Madison Lake and Buck Creek;

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Zone 2: Alum Creek and Delaware; Zone 3: Lake Logan; Zone 4: East Fork Campground, East Fork Public). Zone 1, 2 and 3 will only be sampled during the week. Zone 4 sampling will occur only on weekends and holidays and will be performed in conjunction with the health survey. Sampling locations and frequency are subject to change depending upon funding availability.

Data Analysis: TSI will be evaluated statistically for its significance serving as a real-time indicator of recreational water quality with respect to fecal contamination at each lake and statewide. Other water quality metrics will also be evaluated for their significance at predicting water quality. Statistical analyses will be performed using East Fork health survey and water quality data to evaluate the relationship between health outcomes and water quality. Data analysis and report writing will be performed through June 2010 in conjunction with dissertation writing.

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2008 Pilot Research Grant Awardee Proposal Abstracts Vesicular stomatitis virus as the vector to deliver human Norovirus virus-like particles: a new vaccine strategy against non-cultivable foodborne viruses. Principal Investigator: Jianrong Li, D.V. M., Ph.D. Assistant Professor Department of Food Science and Technology (College of Food, Agricultural and Environmental Sciences) and Division of Environmental Health Sciences (College of Public Health) The Ohio State University 233 Parker Food Science & Tech Bldg 2015 Fyffe Road, Columbus, OH 43210 Office: 614-688-5728; Fax: (614) 292-0218 Email: [email protected] Co-Investigator: Michael Oglesbee, D.V. M., Ph.D., Email: [email protected] Professor, College of Veterinary Medicine, College of Medicine Co-Investigator: Ken Lee, Ph.D., Email: [email protected] Professor, Department of Food Science and Technology, CFAES Co-Investigator: Mark E. Peeples, Ph.D., Email: [email protected] Professor, Department of Pediatrics, The Ohio State University, Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital Collaborator: Linda Saif, Ph.D., Email: [email protected] Professor, Ohio Agricultural Research and Development Center (OARDC), College of Veterinary Medicine Anticipated start date: August 1, 2008; Duration: 2 years; Funds requested: $100,000 Abstract: Human Norovirus (HuNoV) is a major causative agent of foodborne gastroenteritis worldwide. Currently, there are no vaccines or effective therapeutic interventions for this virus. Generally, live attenuated vaccines stimulate strong systemic immunity and provide durable protection due to the continued expression of full viral proteins. Development of an attenuated vaccine for HuNoV has not been possible because it does not grow in cell culture. In this situation, a vectored vaccine may be ideal. It is known that expression of HuNoV capsid (VP1) protein, alone, results in virus-like particles (VLPs) that are structurally and antigenically similar to native HuNoV. The objective of this proposal is to develop vesicular stomatitis virus (VSV) as the vector to deliver a HuNoV VLP vaccine and to explore the 70-kDa heat shock protein (HSP70) as a potential immuno-enhancer for Norovirus vaccine. The Specific Aims are: (1) to generate recombinant VSV expressing HuNoV capsid and/or HSP70 proteins; (2) to determine whether VP1 assembles into VLPs using VSV as the vector; and (3) to determine whether VSV-based vaccine induces a specific immune response and whether HSP70 enhances the immune response in a mice model. This recombinant system will not only provide a new avenue for the development of vaccines for non-cultivable foodborne viruses, but also may lead to discover a new adjuvant, HSP70, for Norovirus vaccine.

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TITLE: Nucleotide synthesis inhibitors as novel therapies for hypoxemia induced by influenza virus infection PRINCIPLE INVESTIGATOR: Ian C. Davis, D.V.M., Ph.D. Assistant Professor Dept. of Veterinary Biosciences 331 Goss Labs, 1925 Coffey Road, Columbus OH 43210 TEL: 292-2954 FAX: 292-6473 E-MAIL: [email protected] COLLABORATORS: Estelle Cormet-Boyaka, Ph.D. Assistant Professor Dept. Of Pulmonary/Critical Care Medicine Daren Knoell, F.C.C.P. Associate Professor Dept. Of Pharmacy, Medicine, and Medical Pharmacology DATES OF FUNDING: 8/1/08 – 7/31/10 LAY SUMMARY: Purpose: This proposal will build upon our recent studies demonstrating that influenza virus inhibits alveolar fluid clearance (AFC) in BALB/c mice by a nucleotide-mediated mechanism. Studies examining effects of influenza infection on ion transport by primary human airway epithelial cell monolayers will show that these findings have relevance to human lung. The efficacy of nucleotide synthesis inhibitors will be tested in vitro and in vivo, to determine whether these agents might be developed as therapies for lung edema and hypoxemia in influenza-infected patients. Relevance: Influenza is of significant concern to human and veterinary public health. The nucleotide synthesis pathway, which our studies indicate is central to AFC inhibition by influenza virus, is a novel molecular target for influenza therapy. This proposal will test new influenza therapeutics based on this target. Impact: Influenza virus causes highly contagious acute respiratory disease that affects approximately 20% of all children and 5% of adults worldwide each year, with significant morbidity and mortality. A successful therapeutic based on this novel target would have a significant impact on influenza morbidity and mortality. Expected outcomes: Pharmacologic blockade of ion transport inhibition by influenza virus may reduce the severity of pulmonary edema and hypoxemia associated with this infection.

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Appendix F

PHPID/CWC TIE Pilot Research Grant Project Awardee Update

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Engaging the Public Health System in Reducing the Societal Carbon Footprint Led by PI J. Mac Crawford, College of Public Health

in collaboration with Co-PI Robyn Wilson, School of Environment and Natural Resources, College of Food, Agricultural and

Environmental Sciences

1. Project Description: This project is designed to, in part, address the CWC question of: “How is the carbon cycle

being disrupted by human activities (e.g., fossil fuel combustion) and how can the cycle be re-balanced to mitigate Anthropogenic Climate Change (ACC) and its adverse effects?” Specifically, the project seeks to identify the most effective ways to move the public health system to adopt strategies aimed at reducing the carbon footprint on a population scale. As ACC continues, the effects on public health are anticipated to worsen: shortages of food and water are developing and will intensify; the extent and range of disease-carrying insect vectors will broaden; destruction of coastal areas through rising ocean levels and storm-surge flooding will affect millions; and intensified summer temperature extremes will threaten, directly and indirectly, millions more. The “twin” issue of peak oil, or the world’s reaching the maximum rate of petroleum extraction, poses different risks than ACC does – depletion of energy resources amplifies all of the previously mentioned threats by limiting societies’ ability to provide resources toward ACC mitigation. These issues all devolve back to the collective carbon footprint of U.S. citizens and are potentially solvable through society-wide behavior change. This project will begin with a descriptive survey of U.S. state and local health departments to assess their baseline understanding of the general concept of carbon footprint and its attendant problems as outlined above. Secondly, the experimental arm of the study will be a pilot intervention project. A “tool kit” of resources will be disseminated to facilitate health departments’ engagement with citizens, the business community, and other governmental agencies with the aim of enhancing public cooperation in reducing the collective carbon footprint.

To measure the effectiveness of this intervention, a control group will receive a packet of information about the carbon footprint and how it affects linked systems generally under the purview of the public health system. The two groups will be followed over time to assess the degree of “buy-in” to the issues, the level of involvement in trying to shape community behavior, and the amount of resources being devoted to the issues. Rogers’ Diffusion of Innovations model will be used to assess the differences between the groups. This project will proceed in 4 phases. a. We will survey local health departments and public health preparedness centers to assess their knowledge, attitudes, and beliefs about peak oil and climate change; and the degree to which they take those issues into account when engaging in preparedness planning and training. b. We will recruit local health departments and public health preparedness centers into an intervention study wherein the control group will receive information about climate change and peak oil, and some information on the need for public health to take them into account. The treatment group will receive a “tool kit” of training materials that they can use to train their own workforce and others in the community. They will receive multimedia information on the need for public health to adopt energy conservation as the “new germ theory.”

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c. We will follow-up with additional knowledge and attitude measures three months, six months, and one-year post baseline to ascertain the degree to which the departments have taken on the issues. We will use Everett Rogers’ Diffusion of Innovation to model the adoption of the new energy conservation paradigm. d. We will seek funding from the CDC through a preparedness mechanism, the broader project incorporating chambers of commerce in addition to health departments and preparedness centers.

2. Products and Deliverables: I was on a special research assignment autumn quarter of 2008 and was consequently off

campus and focused on occupational health research. We really only began our project in earnest winter quarter. Expenditures thus far track with this timeline (see number 4 below).

Our first step has been hiring one undergraduate (Ms. Sana Syal, SENR) and one PhD student (Jonathan Lutz, CPH). Mr. Lutz has only recently begun receiving support from this project – he was on a HRSA for the first two quarters of this academic year. Ms. Syal has been assisting Dr. Wilson (Co-PI) in her development of baseline questionnaires for year 1 and the behavioral intervention that will be undertaken in year 2. She has also been working with Mr. Lutz in assembling a sampling frame of all state, local, and territorial health departments in the District of Columbia, the United States, and its territories (see below).

The project’s year-1 aim of conducting a nationwide survey of health departments is in process and the team has completed about 75% of the assembly of the sampling frame mentioned above. This is a painstaking task, requiring the search for health departments located in every county, city, and state in the union and its territories. We expect to populate the sampling frame with several thousand entries by the time we have finished. Until now, the only such frame was available from the National Association of County and City Health Officials (NACCHO), at a cost of $1,000. Their sampling frame is available only for the effort for which fees were paid, and is incomplete. The assembly of this sampling frame represents the first valuable product to come out of this pilot project. The frame could be used by our group, and many others in our Colleges and elsewhere on campus. Additional licensing opportunities involving outside entities could provide a source of revenue.

We have assembled the full IRB application and are ready to submit it, after creating the questionnaires that will be used in both phases of the project.

3. How the Project Generated New Research or New Funding: Since the project is really only just getting off the ground now, we have not generated any new funding. The opportunities at the federal level for research related to peak oil and climate change, particularly for behavioral research, have been few. CDC released an RFA entitled, “Climate Change: Environmental Impact on Human Health (U01)”. This has been the only announcement I’ve seen and its scope is unrelated to our efforts. To my knowledge there is only one scientist at CDC (or maybe any other federal agency), Howard Frumkin, who even acknowledges the concept of peak oil. As we move ahead with our project, we hope that more attention will be given to these issues and we will see specific announcements we can pursue.

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4. Timeline of Accomplishments and Related Costs: Total Funds = $21,039.50 End of First Six Months of Funding, late 2008: Total first six months funds, $5,500

1. Hired Sana Syal, undergraduate student of Dr. Wilson, $5,500 2. Hired Jonathan Lutz, PhD student of Dr. Crawford at no cost thus far 3. Purchased reference book, $39.50

End of Second Six Months of Funding, early 2009: Total of second six months of funds, $X Continue to fund personnel, Sana Syal, $5,500; Jonathan Lutz, $10,000

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Appendix F

Progress Report

The Global Impact of Terrestrial Surface Waters on the Distribution of Water-Related Infectious Diseases

Led by

Song Liang, Environmental Health Sciences, CPH in collaboration with

Doug Alsdorf, School of Earth Sciences, BMPS Carolyn Merry, Civil & Environmental Engineering, CoE

Jeff LeJeune, Food Animal Health Research Program, OARDC

1. Project Description: Infectious diseases remain among the leading causes of deaths and disability worldwide.

Great efforts have been made to understand the impacts of environmental, ecological, and socio-economic factors on global patterns of these diseases, while poorly understood is the impact of hydrological processes, particularly those related to dynamic patterns of terrestrial surface waters. For example, to what extent do wetlands, floodplains, lakes, and reservoirs influence the distribution and incidence of water-related infectious diseases? Is this a simple relationship where a growing body of water coupled with a pathogen yields an incremental number of infected people? Many complicating factors, such as biology of pathogens, ecological changes, and status of ecological development, are involved. Through an interdisciplinary approach of epidemiology and hydrology, we propose to examine the relationship between spatial and temporal variations in terrestrial surface water and the distribution, emergence, and re-emergence of water-related infectious diseases at regional and global scales. OSU is well-suited for this work. We are the hydrologic home for a new NASA satellite mission specifically designed to measure all of the world’s freshwater bodies. Our hydrology and epidemiology expertise is well recognized, including publications in Nature, Science, and PNAS. The opportunity for future funding from NASA, NIH, and several foundations is substantial.

2. Products and Deliverables: In this pilot project our overall objectives are to understand if the changes in the space

and time patterns and in the availability of global terrestrial surface waters have any impact on the distribution, emergence, and re-emergence of water-related infectious diseases. Our specific aims are to (1) construct a global database for water-related infectious diseases and environmental, ecological, and socio-economic parameters; (2) assess of the use of remote sensing to estimate key parameters associated with terrestrial surface water resources at the global scale; (3) test the hypothesis that changes in spatio-temporal distributions of terrestrial surface water drive the emergence and re-mergence of water-related infectious diseases; and (4) develop a predictive risk model and generate risk maps of water-related infectious diseases.

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2.1 Details for Aim 1: Construction of a global database for water-related infectious diseases and socio-environmental factors The task for this specific aim is the foundation for the whole project. This work was

started in the mid-February when Dr. Kun Yang joined us to work on the project. We are currently building on this database based on comprehensive and extensive literature review (primary sources of references are from Taylor et al., 2001; Guernier et al., 2004; and Jones et al., 2008) and subscription to the Global Infectious Disease and Epidemiology Network database (http://www.cyinfo.com). We have identified 1415 pathogens and 346 diseases and developed structures of the database for both pathogens and diseases, respectively. The database has three major components – the first contains general information about the pathogens and infectious diseases, the second part relates to epidemiology (e.g. distribution), and the third is outbreak information about the pathogens and disease.

For each pathogen/disease, we review first the general information which includes names of the specific disease and the causal agent such as genus and species, taxonomic group of disease (e.g., bacteria, virus, fungi, and helminthes), and their emerging or re-emerging status based on the WHO definitions. The year when the first cluster of pathogen and/or disease was reported is carefully reviewed through literature search and geographical location of the occurrence is derived. For each subject, its transmission pathway (direct transmission, vector transmission, direct environmental transmission, indirect environmental transmission, zoonotic vector transmission, and non-vector zoonotic transmission based on the classification scheme developed earlier by us), relationship to water (water-borne, water-based, water-related, and water dispersed, each of them has specific definition), whether a vector (e.g. insects) and/or other animals are part of the pathogen circulation are analyzed and identified. Epidemiological information includes endemic/epidemic countries and the first or earliest year when the disease/pathogen was reported. Outbreak information includes time and place of the outbreak. Geographical information (e.g. longitudinal and latitudinal information of each pathogen, disease, and outbreak) are derived. All three components of the database are linked through a common identifier. The work is ongoing and we have finished about 350 pathogens so far. We expect to finish the 1st version of the database in late April or early May.

In addition, a global socio-environmental database is also under construction. The database includes information on population and economic status which are derived from various sources. Grid data on world population and population density for 1990, 1995, 2000, 20005, and 2010, global land-cover data for 2000 have been collected. This database is expected to be finished by the mid-May.

Although not funded through this seed grant, Dr. Jiyoung Lee, an environmental microbiologist at CPH, kindly offers her help assessing validity of the database. Mr. Chris Rea, an MPH student at CPH, is involved in this work.

2.2 Details for Aim 2: Development of global water database The primary structure (for information needed for exploring the disease/pathogen-water

relationships) has been developed. The team is working with Drs. C.K. Shum and Hyongki Lee to nail down some specific water parameters that can be estimated from satellite images in

http://www.cyinfo.com/

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Appendix F

certain selected regions. Information on the global coverage of water distribution has been collected from Global Lakes and Wetland Database (GLWD). Its utility is under exploration now.

3. How the Project Generated New Research or New Funding: Based on the current project, the team has already submitted a proposal entitled

“Environmental Risk-oriented Surveillance of Water-related Infectious Disease Based on Satellite Observations” to NASA (2009 – 2011, pending). The research team is planning to submit a new proposal to USDA in May, 2009 related to applications of geospatial techniques to help identification of water- and food-borne pathogens.

4. Timeline of Accomplishments and Related Costs: CWC/PHPID Funding: Jan 2009 – Dec 2010, $ 100,000 Led by Dr. Song Liang (unpaid) Team Members: Dr. Doug Alsdorf (unpaid) Dr. Carolyn Merry (unpaid) Dr. Jeff LeJeune (unpaid) Dr. Kun Yang (paid) Dr. C.K. Shum (unpaid) Dr. Hyongki Lee (unpaid)

Dr. Jiyoung Lee (unpaid) Total first six months funds, $ 25,000

4. Hire personnel. The project has hired Dr. Kun Yang, an epidemiologist who specializes in spatial epidemiology of infectious disease, to work full-time on this project. Dr. Yang officially started on February 15, 2009. $ 2,500/month + 16% benefits

5. Travel to collect data, $ 0 6. Desktop workstation, paid by the PI’s other grants

Publications to date based on CWC/PHPID funding of this project None

2008 Annual Report

Appendix G

2008 PHPID Member External Grant Awards

Table 4

2008 PHPID Member External Grants Submitted

Table 5

2008 Annual Report



www.phpid.osu.edu

Appendix G

Table 4 – 2008 PHPID Member External Grant Awards

Am Heart Assn-Great Rivers Affiliate

Virulence mechanisms promoting fungal pathogen survival within host macrophages

Rappleye, Chad Alan 1-Jul-08 $51,425

Nat Ctr Complementary & Alternative Med

Treatment of cutaneous leishmaniasis using Pentalinon andrieuxii root extract

Satoskar, Abhay R; Kinghorn, A Douglas

1-Feb-09 $184,500

Nat Inst Gen Medical Scis

Biochemistry of lysyl-tRNA synthetases Ibba, Michael 10-Jan-08 $307,500


Biochemistry of lysyl-tRNA synthetases Ibba, Michael 10-Jan-08 $276,750

Nat Inst of Allergy &Infectious Diseases

Salmonella polymicrobial interactions Ahmer, Brian M 15-May-08 $505,098


Isolation of novel antileishmanial molecules from Pentalinon andreuxii root

Satoskar, Abhay R; Kinghorn, A Douglas; Schlesinger, Larry S

18-Sep-08 $173,250


Chemokines and regulation of T cell responses during infection

Satoskar, Abhay R 15-Sep-08 $300,000

National Heart, Lung, and Blood Inst

Control of P. aeruginosa algD transcription

Wozniak, Daniel John 5-Jan-09 $89,494

National Institutes of Health

tRNA Editing by deamination: Balancing affinity and specificity

Alfonzo, Juan De Dios 1-Aug-08 $319,430

NSF Molecular & Cellular Biosciences

Collaborative Research: The role of quality control in microbial translation

Ibba, Michael 1-Mar-08 $78,239


Collaborative Research: The role of quality control in microbial translation

Ibba, Michael 1-Mar-08 $80,976

Wake Forest Univ Bordetella biofilms and pathogenesis Wozniak, Daniel John 1-Oct-08 $4,112 Coop State Res Educ & Extension Service

Mechanisms coordinating protozoal growth and recycling: toward improved efficiency of protein usage in the rumen

Firkins, Jeffrey L; Yu, Zhongtang 15-Mar-08 $349,020

Ohio Soybean Cncl Production of yeast probiotics from crude glycerol derived from soybean-based biodiesel

Yu, Zhongtang; Eastridge, Maurice Lenuel

1-Dec-08 $38,733

Univ of Arkansas Live recombinant Salmonella vaccination with novel universal antigen presentation and immune potentiation

Cole, Kimberly 15-Jan-08 $143,971

Appleton High pressure processing of selected packaging material from Appleton

Balasubramaniam, V M 29-Aug-08 $59,033

Coop State Res Educ & Extension Service

Quality of foods processed using selected alternative processing technologies

Sastry, Sudhir K; Balasubramaniam, V M; Schwartz, Steven J

1-Jan-09 $340,334


Conference on food safety and public health: Minimizing antibiotic resistance transmission through the food chain

Wang, Hua 1-Sep-08 $50,000


Combating the transmission of antibiotic resistance through the global food chain

Wang, Hua 1-Sep-08 $99,979

2008 Annual Report



www.phpid.osu.edu

Appendix G

Interstitial Cystitis Assn

Validation of a rapid and high throughput method of diagnosis of interstitial cystitis by infrared microspectroscopy

Rodriguez-Saona, Luis E; Buffington, Charles A; Gilleran, Jason P

21-Nov-08 $3,200

Kraft Foods, Inc Enterocin RM1: a novel bacteriocin characterization and potential application in food

Yousef, Ahmed E 1-Jun-08 $55,246

OH Water Dev Authority

Protecting public health at Ohio inland beaches: Development of water quality indicators for recreational microbial exposure

Buckley, Timothy J 17-Dec-08 $13,701

Univ of Nebraska Rapid determination of grape content in commercial grape juices by infrared spectroscopy

Giusti, M Monica; Rodriguez-Saona, Luis E

1-Jul-08 $10,000

USDA Foreign Ag Serv

Improving the safety and quality of ready-to-eat meat products using novel protective and probiotic bacterial cultures

Yousef, Ahmed E 14-Aug-08 $31,021


Quality of foods processed using selected alternative processing technologies

Sastry, Sudhir K; Balasubramaniam, V M; Schwartz, Steven J

1-Jan-09 $340,334


Wet scrubbers for the recovery of NH3 emissions

Zhao, Lingying; Keener, Harold M; Rausch, Jonathan N

1-Mar-08 $599,836

Food and Drug Administration

Inches analysis of nutrition profiles Hooker, Neal H 15-Sep-08 $5,000

Nat Res Init Competitive Grants Program

Organic food marketing: Panacea or problem?

Hooker, Neal H; Batte, Marvin T 1-Jan-08 $384,305




18-Sep-08 $11,250


Remodeling of the M. tuberculosis cell wall by the host microenvironment

Torrelles, Jordi B 1-Aug-08 $90,000


Pharmacogenetics of sulfamethoxazole in HIV/AIDS patients

Wang, Danxin; Sadee, Wolfgang 1-Jun-08 $18,000



Wozniak, Daniel John 5-Jan-09 $208,820

OH Dept of Public Safety

MRSA colonization in EMS personnel and equipment as a risk factor for secondary infections in Ohio trauma patients

Stevenson, Kurt B; Hoet, Armando E; Lu, Bo

1-Jul-08 $9,999

Oxford Immunotec Limited

Evaluation of the use of T-Cell Xtend with T-Spot.TB to increase the storage time of blood samples

Wang, Shu-Hua 18-Sep-08 $31,112

Pfizer Inc An international, multicenter, prospective observational study of the safety of Maraviroc used with optimized background therapy in treatment experienced HIV 1 infected patients

Para, Michael F; Koletar, Susan L 15-Jun-08 $0

2008 Annual Report



www.phpid.osu.edu

Appendix G

Social & Scientific Systems, Inc

ACTG 5224s: A substudy of protocol A5202: long-term metabolic assessments in subjects treated with Emtricitabine/Tenofovir of Abacavir/Lamivudine with either Efavirenz or Atazanavir with Ritonavir.

Koletar, Susan L 1-Sep-08 $0


ACTG 5224s: A substudy of protocol A5202: long-term metabolic assessments in subjects treated with Emtricitabine/Tenofovir of Abacavir/Lamivudine with either Efavirenz or Atazanavir with Ritonavir.

Koletar, Susan L 1-Sep-08 $24,700

Tibotec Pharmaceuticals Ltd

A phase III, randomized, double-blind trial of TMC278 25mg qd vs efavirenz 600mg qd in combination with a fixed background regimen consisting of tenofovir disoproxil fumarate & emtricitabine in antiretroviral naive HIV-1 infected subjects

Para, Michael F 6-May-08 $0



Para, Michael F 6-May-08 $4,430










Wake Forest Univ Bordetella biofilms and pathogenesis Wozniak, Daniel John 1-Oct-08 $9,595 Nat Inst of Allergy &Infectious Diseases


Wang, Danxin; Sadee, Wolfgang 1-Jun-08 $11,250

2008 Annual Report



www.phpid.osu.edu

Appendix G




1-Jul-08 $5,000

Johns Hopkins Univ A randomized controlled trial of the combination of two school-based, universal preventive interventions

Murray, David 1-Jul-08 $63,893

Nat Ctr Minority Hlth & Hlth Disparities

CBPR strategies to increase colorectal cancer screening in Ohio Appalachia

Paskett, Electra D; Katz, Mira L; Murray, David ; Raup Krieger, Janice L; Slater, Michael D

28-May-08 $545,187

Nat Ctr Minority Hlth & Hlth Disparities

CBPR strategies to increase colorectal cancer screening in Ohio Appalachia

Paskett, Electra D; Katz, Mira L; Murray, David ; Raup Krieger, Janice L; Slater, Michael D

28-May-08 $205,296

Nat Inst Occupational Safety & Health

Developing and Evaluating New Approaches to Youth Agricultural Injury Prevention

Wilkins, John R III; Murray, David ; Shen, Lei

1-Sep-07 $382,277

National Cancer Institute

Smokeless tobacco marketing approaches to Ohio Appalachian populations

Wewers, Mary E; Ferketich, Amy K; Kwan, Mei-Po

21-Jul-08 $43,877




1-Jul-08 $49,996

OH Tobacco Use Prevention & Control Fdn

Funding for Student Interns Pirie, Phyllis L; Ferketich, Amy K 1-Jan-08 $7,476

Univ of Cincinnati Bioaerosols in midwest greenhouses and respiratory symptoms among the workers

Wilkins, John R III 1-Aug-08 $10,172

Univ of Washington Community youth development study Murray, David 1-Nov-08 $18,128 HALO Technologies, Inc

Evaluation of a u-equipped vacuum cleaner for inactivation of surface embedded microorganisms

Buckley, Timothy J; Needham, Glen R

1-Mar-08 $16,279


Protecting public health at Ohio inland beaches: Development of water quality indicators for recreational microbial exposure

Buckley, Timothy J 17-Dec-08 $157,558

John F Fogarty International Center

OSU Center for Global Health Sedmak, Daniel D; Love, Richard R; Wewers, Mary E

10-Sep-08 $60,587


Genetic and signaling pathways in epithelial thyroid cancer

Ringel, Matthew D; Chen, Ching-Shih ; Cope, Frederick ; Fernandez, Soledad A; Jhiang, Sissy M; Lemeshow, Stanley A; Nagy, Rebecca Jo; Rosol, Thomas J; Saji, Motoyasu ; Suster, Saul ; Tsai, Ming-Daw ; Wakely Jr., Paul E.; Yu, Lianbo

1-Mar-08 $112,792

2008 Annual Report



www.phpid.osu.edu

Appendix G


Genetic and signaling pathways in epithelial thyroid cancer

Ringel, Matthew D; Chen, Ching-Shih ; Cope, Frederick ; Fernandez, Soledad A; Jhiang, Sissy M; Lemeshow, Stanley A; Nagy, Rebecca Jo; Rosol, Thomas J; Saji, Motoyasu ; Suster, Saul ; Tsai, Ming-Daw ; Wakely Jr., Paul E.; Yu, Lianbo

1-Mar-08 $140

OH Dept of Health Public engagement demonstration project on pandemic influenza-rural(initiative B)

Buckley, Timothy J; Pearsol, Joanne

10-Aug-08 $200,000

OH Dept of Health Public engagement demonstration projects on pandemic influenza (initiative A)

Buckley, Timothy J; Pearsol, Joanne ; Stanley, Sharon A

30-Sep-08 $144,120

OH Dept of Health Training of Public Health Personnel and Public Health Partners in the "Planning P Process" for a Type 3 Incident

Holtzhauer, Francis J 21-Apr-08 $88,076

OH Dept of Health Maternal and child health block grant five year needs assessment facilitation

Holtzhauer, Francis J 1-Sep-08 $3,641


Novel translation control strategy for junD, a potential modulator of cardioprotection and hypertrophy

Boris-Lawrie, Kathleen A 1-Jul-08 $21,000

Army Medical Res Acquisition Activity

Ets2 contributions of the tumor microenvironment in breast cancer metastasis

Werbeck, Jillian L; Rosol, Thomas J

1-Mar-08 $97,010


Haptoglobin-matrix metalloproteinase-9: a bio-marker influencing macrophage function

Lakritz, Jeffrey; Premanandan, Christopher ; Rajala-Schultz, Paivi J

1-Aug-08 $18,750

Merial Ltd A challenge trial conducted in gnotobiotic swine to determine if selected materials used for production of Merial swine biologicals contain infectious torque teno viruses

Krakowka, George S 6-May-08 $46,200

Merial Ltd Feasibility study for two experimental Helicobacter pylori-like Organism (HPLO) vaccines by vaccination-challenge in gnotobiotic pigs at OSU

Krakowka, George S 15-Sep-08 $48,810

Merial Ltd Feasibility study for two experimental Helicobacter pylori-like Organism (HPLO) vaccines by vaccination-challenge in gnotobiotic pigs at OSU

Krakowka, George S 15-Sep-08 $15,000

Morris Animal Fdn The in vitro effects of histone deacetylase inhibitors on feline oral squamous cell carcinoma

Kisseberth, William C; London, Cheryl A; Rosol, Thomas J

1-Dec-08 $8,100

Morris Animal Fdn Effect of combined zoledronic acid and piroxicam on feline oral squamous cell carcinoma

Rosol, Thomas J; Kisseberth, William C; London, Cheryl A; Martin, Chelsea K

1-Dec-08 $105,082

Nat Inst Neurological Disorders & Stroke

Preclinical toxicity evaluation of a potent oncolytic virus

Chiocca, E Antonio; Oglesbee, Michael J; Saeki, Yoshinaga

30-Sep-08 $25,250

2008 Annual Report



www.phpid.osu.edu

Appendix G


Alternative approaches for NALT-based immunity to respiratory pathogens

Boyaka, Prosper N; Cormet-Boyaka, Estelle ; Davis, Ian C

1-Dec-08 $356,250


Heat shock protein modulation of paramyxoviral disease

Oglesbee, Michael J; Niewiesk, Stefan

1-Feb-08 $187,500


Heat shock protein modulation of paramyxoviral disease

Oglesbee, Michael J; Niewiesk, Stefan

1-Feb-08 $202,500


Type IV secretion & signal transduction in Ehrlichiosis

Rikihisa, Yasuko 1-Jan-09 $375,000


Immune correlates of reactivation tuberculosis

Turner, Joanne 1-Apr-07 $7,358


Retrovirus models of lymphocyte transformation and disease

Lairmore, Michael D 23-Jun-08 $2,094,373

NexBio, Inc. Testing anti-parainfluenza virus drug Niewiesk, Stefan 1-Mar-08 $13,530 Coop State Res Educ & Extension Service

Haptoglobin-matrix metalloproteinase-9: a bio-marker influencing macrophage function

Lakritz, Jeffrey; Premanandan, Christopher ; Rajala-Schultz, Paivi J

1-Aug-08 $18,750

Nat Pork Board Prevalence and characterization of Methicillin Resistant Staphylococcus Aureus (MRSA) in pigs and farm workers on conventional and antibiotic free swine farms in the USA.

Gebreyes, Wondwossen A; Hoet, Armando E

1-Aug-08 $30,000

Nat Pork Board Genotyping of campylobacter coli in pigs from farm to fork

Gebreyes, Wondwossen A; Wittum, Thomas E

1-Oct-08 $4,100

Nat Pork Board Noroviruses in finisher swine: Prevalence and relatedness to human noroviruses

Saif, Linda J; Gebreyes, Wondwossen A; Hoet, Armando E

1-Nov-08 $4,000

OH Dept of Health Educational program initiative to prevent the emergence and spread of antimicrobial resistance

Hoet, Armando E 25-Sep-08 $0




1-Jul-08 $34,997

Univ of Maryland Prevention and control of avian influenza in the US.

Slemons, Richard D 1-May-08 $232,301

Winn Feline Foundation

Adrenocortical function in cats with feline interstitial cystitis (FIC)

Buffington, Charles A; Lord, Linda Kay

1-Jan-08 $1,296

Army Development of a novel tissue specific aromatase activity regulation therapeutic method

Brueggemeier, Robert W; Lee, Robert J; Sugimoto, Yasuro

1-Sep-08 $371,498


Blocking prostate tumorigenesis with novel small-molecule agents

Chen, Ching-Shih; Kulp, Samuel K 1-Sep-08 $562,500




18-Sep-08 $40,500


Targeting proapoptotic PKCdelta signaling in hepatocellular carcinoma

Chen, Ching-Shih; Kulp, Samuel K 1-Jan-09 $150,000


Indole-3-carbinol derivatives with enhanced chemopreventive activities

Chen, Ching-Shih; Kulp, Samuel K 1-Jan-09 $150,000


Boronated nucleosides for neutron capture therapy of brain tumors

Tjarks, Werner; Barth, Rolf F 1-Jan-09 $226,262

2008 Annual Report



www.phpid.osu.edu

Appendix G

Army Development of a novel tissue specific aromatase activity regulation therapeutic method

Lee, Robert J; Brueggemeier, Robert W; Sugimoto, Yasuro

1-Sep-08 $375,000

East Tennessee State Univ

Checkpoint signaling and repair of UV damage to human DNA

Kvaratskhelia, Mamuka 22-Sep-08 $31,500


Structural studies of HIV-1 integration Kvaratskhelia, Mamuka 1-Jan-06 $292,205

$13,591,135

2008 Annual Report



www.phpid.osu.edu

Appendix G

Table 5 – 2008 PHPID Member External Grants Submitted


Intracellular trafficking of Histoplasma

EDWARDS, JESSICA ANNE; RAPPLEYE, CHAD ALAN

1-Jul-09 $88,000 Pending


Naturally occurring genetic variants in human mitochondrial protein synthesis: Implications for organelle dysfunction

IBBA, MICHAEL; BANERJEE, RAJAT




RAPPLEYE, CHAD ALAN

1-Jul-08 $102,850 Awarded

Bill & Melinda Gates Fdn


SATOSKAR, ABHAY R; KINGHORN, A DOUGLAS

1-Sep-08 $80,000 Pending

Burroughs Wellcome Fund

Host Responses to the Cholesterol-Dependent Cytolysin toxins

SEVEAU, STEPHANIE MARTHE MARIE



Regulation of Bacillus Subtilis tRNA synthetase genes

HENKIN, TINA M 1-Jan-09 $1,500,000 Awarded


Cellular, molecular and biochemical scinces training grant

MUSIER-FORSYTH, KARIN M; IBBA, MICHAEL



A method to stop HIV replication: inhibition of human purine utilizing proteins

KWIEK, JESSE JOHN 1-Jul-09 $571,944 Pending


Superbugs, Science, and Society: An Infectious Disease Curricular Program

KWIEK, NICOLE CARTWRIGHT; D'AGOSTINO, JEROME VICTOR; HALE, KENNETH MICHAEL; KWIEK, JESSE JOHN

1-Dec-08 $6,988 Pending



KWIEK, NICOLE CARTWRIGHT; HALE, KENNETH MICHAEL; KWIEK, JESSE JOHN

1-Aug-09 $7,065 Pending


Regulation and function of hepcidin in M.tuberculosis infected macrophages

LAFUSE, WILLIAM P; SATOSKAR, ABHAY R; SCHLESINGER, LARRY S; TURNER, JOANNE

1-Apr-09 $93,750 Pending


Bloodstream detection of secreted Aspergillus antigens as diagnostic markers

RAPPLEYE, CHAD ALAN

1-Dec-09 $1,109,194 Pending


Isolation of novel antileishmanial drug from Pentalinon andreuxii root

SATOSKAR, ABHAY R; KINGHORN, A DOUGLAS; SCHLESINGER, LARRY S

1-Apr-09 $317,625 Awarded

2008 Annual Report



www.phpid.osu.edu

Appendix G


Pseudomonas biofilms and persistence

WOZNIAK, DANIEL JOHN

1-Oct-08 $42,251 Awarded


The matrix of Pseudomonas aeruginosa biofilms


1-Oct-08 $108,968 Pending


Immobilization of thermostable amylolytic enzymes for improved reusability at high temperature of starch hydrolysis process

KALETUNC, GONUL; LI, YEBO; REEVE, JOHN N

1-Oct-08 $24,999 Not Funded






OSU-MIDAS center for computational modeling of global infectious disease threats

FRIEDMAN, AVNER; CATALYUREK, UMIT V; DESAI, ANAND; HOET, ARMANDO E; IBARAKI, MOTOMU; JANIES, DANIEL A; KWIEK, JESSE JOHN; LIANG, SONG; PEARL, DENNIS K; SCHLESINGER, LARRY S; STEVENSON, KURT B; WANG, SHU-HUA



Macrophage iron homeostasis and M. tuberculosis infection




Genetic discovery of fungal virulence determinants

RAPPLEYE, CHAD ALAN

1-Oct-08 $1,657,500 Pending


MIF: A novel drug target and a biomarker in NMSC MIF as a novel drug target and a biomarker in NMSC MIF as a novel drug target and a biomarker in NMSC MIF as a novel drug target and a biomarker in NMSC

SATOSKAR, ABHAY R; OBERYSZYN, TATIANA M

1-Dec-09 $321,750 Not Funded




1-Dec-08 $338,250 Awarded


Prevention and treatment of non-melanoma skin cancer by targeting MIF


1-Nov-09 $1,453,479 Pending


Macrophage migration inhibitory factor (MIF) and regulation of immunity against T. gondii

SATOSKAR, ABHAY R; RAY CHAUDHURY, ABHIK

1-Jun-09 $1,781,250 Pending

2008 Annual Report



www.phpid.osu.edu

Appendix G


Role of macrophage migration inhibitory factor (MIF) in toxoplasmosis

SATOSKAR, ABHAY R 1-Jan-09 $1,875,000 Not Funded


Mammalian cell subversion by the cholesterol-dependent cytolysin toxins






1-Jul-09 $1,074,490 Pending

NSF Behavorial & Cognitive Sciences

Regulation of Nitrogen Assimilation in the Haloarchaea

DANIELS, CHARLES J 1-Jan-09 $320,181 Pending

Sidney Kimmel Cancer Center

Salmonella genes associated with colonization of specific hosts

AHMER, BRIAN M 1-Dec-08 $436,704 Pending

US Department of Energy

Hyperthermophilic hydrogen production: Evaluation and manipulation of Thermococcus kodakaraensis

REEVE, JOHN N 1-Jul-08 $734,203 Not Funded

Wake Forest Univ

Bordetella Biofilms and Pathogenesis WOZNIAK, DANIEL JOHN


Georgetown Univ

Massively parallel sequencing of the diapause transcriptome of Aedes albopictus

DENLINGER, DAVID L 1-Dec-08 $76,200 Not Funded

Georgetown Univ

Massively parallel sequencing of he diapause transciptome of Aedes albopictus

DENLINGER, DAVID L 1-Jul-09 $111,900 Pending


The Floral Dimension of African Malaria

FOSTER, WOODBRIDGE A

1-Sep-09 $2,722,560 Pending


The Floral Dimension of African Malaria

FOSTER, WOODBRIDGE A

1-Dec-08 $2,836,580 Pending

NSF Biological Sciences

Mechanisms of Rapid and Winter Cold-Hardening in Insects

DENLINGER, DAVID L 1-Aug-09 $336,671 Pending

NSF Integrative Organismal Biology

Doctoral Dissertation Improvement Grant in the Biological Sciences: Molecular and physiological responses to desiccation during mosquito dormancy (for Joshua Benoit)

DENLINGER, DAVID L 1-Jun-09 $14,900 Pending

NSF Ofc Polar Programs

Collaborative Proposal: Roles for Dehydration and Photoperiodism in Preparing an Antarctic Insect for the Polar Night

DENLINGER, DAVID L 1-Apr-09 $422,821 Pending


Intracellular trafficking of Histoplasma

EDWARDS, JESSICA ANNE; RAPPLEYE, CHAD ALAN



Naturally occurring genetic variants in human mitochondrial protein synthesis: Implications for organelle dysfunction

IBBA, MICHAEL; BANERJEE, RAJAT


2008 Annual Report



www.phpid.osu.edu

Appendix G



RAPPLEYE, CHAD ALAN







Host Responses to the Cholesterol-Dependent Cytolysin toxins




Regulation of Bacillus Subtilis tRNA synthetase genes

HENKIN, TINA M 1-Jan-09 $1,500,000 Awarded







KWIEK, JESSE JOHN 1-Jul-09 $571,944 Pending















RAPPLEYE, CHAD ALAN

1-Dec-09 $1,109,194 Pending














Immobilization of thermostable amylolytic enzymes for improved reusability at high temperature of starch hydrolysis process

KALETUNC, GONUL; LI, YEBO; REEVE, JOHN N


2008 Annual Report



www.phpid.osu.edu

Appendix G















RAPPLEYE, CHAD ALAN

1-Oct-08 $1,657,500 Pending


MIF: A novel drug target and a biomarker in NMSC MIF as a novel drug target and a biomarker in NMSC MIF as a novel drug target and a biomarker in NMSC MIF as a novel drug target and a biomarker in NMSC


1-Dec-09 $321,750 Not Funded






Prevention and treatment of non-melanoma skin cancer by targeting MIF


1-Nov-09 $1,453,479 Pending


Macrophage migration inhibitory factor (MIF) and regulation of immunity against T. gondii

SATOSKAR, ABHAY R; RAY CHAUDHURY, ABHIK

1-Jun-09 $1,781,250 Pending


Role of macrophage migration inhibitory factor (MIF) in toxoplasmosis

SATOSKAR, ABHAY R 1-Jan-09 $1,875,000 Not Funded








1-Jul-09 $1,074,490 Pending

NSF Behavorial & Cognitive Sciences

Regulation of Nitrogen Assimilation in the Haloarchaea

DANIELS, CHARLES J 1-Jan-09 $320,181 Pending

2008 Annual Report



www.phpid.osu.edu

Appendix G

NSF Biological Sciences

Carbon flow through the Ethylmalonyl-CoA pathway

ALBER, BIRGIT 1-Feb-09 $469,123 Pending


Studies of translation initiation in bacteria

FREDRICK, KURT L 1-Feb-09 $533,926 Awarded


Consequences of RubisCO Active-Site Modifications in Anaerobic Archaea and Bacteria

TABITA, F ROBERT 1-Aug-08 $757,358 Not Funded


Consequences of RubisCO active-site modifications in anaerobic archaea and bacteria

TABITA, F ROBERT 1-Aug-09 $789,415 Pending

Sidney Kimmel Cancer Center

Salmonella genes associated with colonization of specific hosts

AHMER, BRIAN M 1-Dec-08 $436,704 Pending

US Department of Energy

Hyperthermophilic hydrogen production: Evaluation and manipulation of Thermococcus kodakaraensis

REEVE, JOHN N 1-Jul-08 $734,203 Not Funded

Wake Forest Univ



Food and Drug Administration

Analysis of Nutrition Profiles of Food Products: Transfat

HOOKER, NEAL H 1-Oct-08 $5,000 Awarded

University Of Toledo

Commercialization of Functional Ingredients and Biologically Active Products from Ohio Ag Bioscience.

LEE, KENNETH; CLINTON, STEVEN K; HOOKER, NEAL H; SCHWARTZ, STEVEN J; VODOVOTZ, YAEL


Appleton High Pressure Processing of selected packaging material from Appleton

BALASUBRAMANIAM, V M



Conference on Food Safety and Public Health: Minimizing Antibiotic Resistance Transmission through the Food Chain

WANG, HUA 1-Sep-08 $50,000 Awarded


Combating the Transmission of Antibiotic Resistance through the Global Food Chain

WANG, HUA 1-Sep-08 $99,979 Awarded

Defense Logistics Agency

CORANET Partnership-The Ohio State University

BALASUBRAMANIAM, V M; ALVAREZ, VALENTE B; LEE, KENNETH; SASTRY, SUDHIR K; SCHWARTZ, STEVEN J; YOUSEF, AHMED E

1-Nov-08 $15,000 Awarded

Global Youth Partnership for Africa

Improving public health by integrating rain collection, biogas production, and education to achieve sustainable access to clean water and energy in Bukomero, Uganda

LEE, JIYOUNG; LIANG, SONG; MARTIN, JAY F


2008 Annual Report



www.phpid.osu.edu

Appendix G

Interstitial Cystitis Assn

Validation of a Rapid and High Throughput Method of Diagnosis of Interstitial Cystitis by Infrared Microspectroscopy

RODRIGUEZ-SAONA, LUIS E; BUFFINGTON, CHARLES A; GILLERAN, JASON P

18-Aug-08

$3,200 Awarded

Kraft Foods, Inc Enterocin RM1: a novel bacteriocin characterization and potential application in food

YOUSEF, AHMED E 1-Jun-08 $55,246 Awarded

Midwest Advanced Food Manufact Alliance

Rapid Determination of Concord Grape Content in Commercial Grape Juices by Infrared Spectroscopy

GIUSTI, M MONICA; RODRIGUEZ-SAONA, LUIS E

1-Sep-08 $10,000 Awarded


Quality of Foods Processed Using Selected Alternative Processing Technologies

SASTRY, SUDHIR K; BALASUBRAMANIAM, V M; SCHWARTZ, STEVEN J


Nat Science Foundation

MAGNETIC SPORES, OPTICAL INFRARED SENSORS AND FLOW CYTOMETRY AS NOVEL TOOLS FOR UNDERSTANDING SPORE INACTIVATION IN FOOD PRODUCTS

RODRIGUEZ-SAONA, LUIS E; CHALMERS, JEFFREY J

1-Jan-09 $239,947 Pending


Messenger RNA cap methlytransferase in paramyxovirus

LI, JIANRONG 1-Mar-09 $395,183 Pending

Ohio Department of Development

Plasma Enhanced Microwave Oven LEE, KENNETH 1-Oct-09 $330,855 Pending

University Of Toledo

Commercialization of Functional Ingredients and Biologically Active Products from Ohio Ag Bioscience.

LEE, KENNETH; CLINTON, STEVEN K; HOOKER, NEAL H; SCHWARTZ, STEVEN J; VODOVOTZ, YAEL

1-Sep-08 $2,272,561 Pending

Allegheny-Singer Research Institute

Does mycobacterium tuberculosis biofilm formation provide novel potential targets for vaccine development

SCHLESINGER, LARRY S


Allegheny-Singer Research Institute

Does biofilm formation change the cell surface of mycobacterium tuberculosis?




Dual bacterial vaccine: bacteriophage as a delivery vehicle

GUNN, JOHN S; SCHLESINGER, LARRY S



Surfactant protein D in protection against tuberculosis



Burroughs Wellcome Co

Integrating infectious disease training from lab-based to population scales

SCHLESINGER, LARRY S; BUCKLEY, TIMOTHY J

1-Feb-09 $1,222,972 Not Funded

International Anesthesia Res Soc

T cell modulation after ischemic spinal cord injury in aortic surgery

ELSAYED-AWAD, HAMDY M; TURNER, JOANNE

1-Feb-09 $8,000 Not Funded

2008 Annual Report



www.phpid.osu.edu

Appendix G

Merck & Co Inc A randomized, double-blind, placebo-controlled trial of caspofungin prophylaxis followed by pre-emptive therapy for invasive candidiasis in high-risk adults in the critical care setting

MANGINO, JULIE E 1-Oct-07 $139,800 Awarded



KWIEK, JESSE JOHN 1-Jul-09 $1,334,535 Pending















RAPPLEYE, CHAD ALAN







Effects of lung mucosal hydrolases on Mycobacterium tuberculosis pathogenesis

TORRELLES, JORDI B; TURNER, JOANNE




WANG, DANXIN; KOLETAR, SUSAN L; LEE, MEI-LING TING; PARA, MICHAEL F; SADEE, WOLFGANG










2008 Annual Report



www.phpid.osu.edu

Appendix G





National Institute on Aging

The influence of increasing age on susceptibility to reactivation tuberculosis

TURNER, JOANNE; WANG, SHU-HUA

1-Apr-09 $2,086,897 Pending


CD8 T cells and immunity to tuberculosis in old mice

TURNER, JOANNE 1-Oct-08 $2,617,805 Pending


CD8 T cells and immunity to tuberculosis in old mice

TURNER, JOANNE 1-Jul-09 $2,727,461 Pending


Role of caspases in legionella pneumophila pulmonary infection

AMER, AMAL; SCHLESINGER, LARRY S; TRIDANDAPANI, SUSHEELA; WEWERS, MARK D





1-Jul-09 $1,496,964 Pending






Leishmania-antimicrobial peptide interactions in parasite pathogenesis

MCGWIRE, BRADFORD S

1-Jul-09 $1,875,000 Pending



RAPPLEYE, CHAD ALAN











Mechanisms of transmission and acquisition of antimicrobial resistance

STEVENSON, KURT B 1-Jul-09 $695,281 Pending

2008 Annual Report



www.phpid.osu.edu

Appendix G


MRSA Colonization in EMS Personnel and Equipment as a Risk Factor for Secondary Infections in Ohio Trauma Patients

STEVENSON, KURT B; HOET, ARMANDO E; LU, BO


Oxford Immunotec Limited

Evaluation of the use of T-Cell Xtend with T-Spot.TB to increase the storage time of blood samples

WANG, SHU-HUA 1-Sep-08 $31,112 Awarded

Pfizer Inc An international, multicenter, prospective observational study of the safety of Maraviroc used with optimized background therapy in treatment experienced HIV 1 infected patients

PARA, MICHAEL F; KOLETAR, SUSAN L

15-Jun-08

$91,617 Awarded


ACTG 5224s: A substudy of protocol A5202: long-term metabolic assessments in subjects treated with emtricitabine of Abacavir/Lamivudine with either Efavirenz or Atazanavir with Ritonavir.

KOLETAR, SUSAN L 1-Sep-05 $24,700 Awarded

The Robert Wood Johnson Fdn

Community-based evaluation and analysis of methicillin-resistant staphylococcus aureus (MRSA) transmission

WANG, SHU-HUA 1-Jul-09 $300,000 Not Funded



PARA, MICHAEL F 1-Apr-08 $50,965 Awarded

Univ of Chicago Host and bacterial targets mediating immune suppression in pneumonic tularemia

SCHLESINGER, LARRY S; GUNN, JOHN S; TRIDANDAPANI, SUSHEELA; WEWERS, MARK D

1-Mar-09 $1,905,893 Pending

Wake Forest Univ



American Association For Cancer Research

Novel breast cancer drug based on diketo curcumin scaffold targeting STAT3

LI, CHENGLONG; FUCHS, JAMES ROBERT; HOYT, DALE G; LI, PUI-KAI; YEE, LISA D


Army Lead Optimization of Reversed Amidines for Cutaneous Leishmaniasis

WERBOVETZ, KARL A 1-Apr-09 $1,066,933 Pending


Potent indole-3-carbinol derivatives for breast cancer chemoprevention and therapy

CHEN, CHING-SHIH; KULP, SAMUEL K

1-Feb-09 $557,120 Pending

2008 Annual Report



www.phpid.osu.edu

Appendix G


Tumor-selective targeting of androgen receptor expression by small-molecule agents




Targeting the JAK/STAT pathway in prostate cancer with novel curcumin analogues. (PC081096)

FUCHS, JAMES ROBERT; HOYT, DALE G; KULP, SAMUEL K; LI, CHENGLONG; LI, PUI-KAI



Dual inhibitor design targeting Jak2 and STAT3 via tautomerically defined curcumin analogues

LI, CHENGLONG; FUCHS, JAMES ROBERT; HOYT, DALE G



Development of novel curcumin analogues for the treatment of Leishmaniasis

FUCHS, JAMES ROBERT; LI, PUI-KAI; WERBOVETZ, KARL A



Novel drugs targeting UDP-glucose pyrophosphorylase to overcome drug-resistance in Leishmaniasis

LI, CHENGLONG; WERBOVETZ, KARL A







Discovery of multi-target agents against kinetoplastid parasites

WERBOVETZ, KARL A 1-Sep-08 $100,000 Pending

Milheim Foundation for Cancer Research

Tautomerically defined curcumin analogues

FUCHS, JAMES ROBERT


Morris Animal Fdn

Biologic activity of the curcumin analog FLLL32 against canine osteosarcoma

LONDON, CHERYL A; FUCHS, JAMES ROBERT; KISSEBERTH, WILLIAM C; KULP, SAMUEL K; PENNELL, MICHAEL L; PHELPS, A MITCHELL



Structural and functional studies of novel mono-nucleotide N-Glycosidases RCL and BLSM

WU, ZHENGRONG JUSTIN; LI, CHENGLONG

1-Oct-09 $1,131,608 Pending


Novel small-molecule, Francisella-targeted therapeutics

KULP, SAMUEL K; CHEN, CHING-SHIH

1-Mar-09 $300,000 Pending






Optimization of reversed amidines for Chagas disease and cutaneous leishmaniasis

WERBOVETZ, KARL A 1-Apr-09 $4,173,997 Pending


Indole-3-carbinol derivatives with enhanced chemopreventive activities



2008 Annual Report



www.phpid.osu.edu

Appendix G


Targeting proapoptotic PKCdelta signaling in hepatocellular carcinoma




Boronated nucleosides for neutron capture therapy of brain tumors

TJARKS, WERNER; BARTH, ROLF F

1-Dec-08 $1,446,735 Awarded


Chemopreventive potential of alpha-tocopheryl succinate derivatives as PP2A-activating agents




Curcumin analogues as inhibitors of the JAK/STAT pathway in cancer

FUCHS, JAMES ROBERT; BENSON, DON M; HOYT, DALE G; LESINSKI, GREGORY; LI, CHENGLONG; LI, PUI-KAI; MISHRA, ANJALI; PHELPS, A MITCHELL



A HTS plan for negative allosteric modulators of nicotinic receptors

MCKAY, DENNIS B; LI, CHENGLONG


Research Institute at Nationwide Childrn

Dual inhibitors target JAK2/STAT3 for novel pancreatic cancer therapy

FUCHS, JAMES ROBERT; LI, CHENGLONG; LI, PUI-KAI; PHELPS, A MITCHELL



New curcumin analogues with enhanced growth suppressive activity as novel therapeutic agents for breast cancer

FUCHS, JAMES ROBERT; CHAN, KENNETH K; LIU, ZHONGFA



Novel curcumin analogues with enhanced growth suppressive activity as new therapeutic agents for prostate cancer.

FUCHS, JAMES ROBERT; KULP, SAMUEL K



Novel curcumin analogues with enhanced growth suppressive activity as new therapeutic agents for breast cancer

FUCHS, JAMES ROBERT



Novel JAK2/STAT3 inhibitors for pancreatic cancer therapy

LI, CHENGLONG; BLOOMSTON, PAUL MARK; FUCHS, JAMES ROBERT; LI, PUI-KAI; PHELPS, A MITCHELL


Susan G Komen Breast Cancer Fdn

Developing novel drugs via small molecule STAT3 inhibition for breast cancer therapy

LI, CHENGLONG; FUCHS, JAMES ROBERT; LI, PUI-KAI; YEE, LISA D


Virginia Commonwealth Univ

OSU-03012 therapy in glioblastoma CHEN, CHING-SHIH 1-Aug-09 $129,760 Pending

World Health Organization

Optimization of novel 2,2,4-trimethyl-1,2-dihydroquinolines as antitrypanosomal agents

WERBOVETZ, KARL A 1-Jul-09 $56,475 Pending

2008 Annual Report



www.phpid.osu.edu

Appendix G


Biochemistry of HIV-1 Gag interactions with the assembly cofactors

SHKRIABAI, NIKOLOZ; KVARATSKHELIA, MAMUKA

1-Jul-08 $88,000 Not Funded


Modulation of DNA Methylation in Breast Cancer by Curcumin

LIU, ZHONGFA; CHAN, KENNETH K


Cleveland Clinic Malignant stem-cell specific differentiation therapy

CHAN, KENNETH K 1-Jul-09 $371,589 Pending


Novel assay for HIV-1 integrase inhibitors

KVARATSKHELIA, MAMUKA



Novel Assay for HIV-1 Integrase Inhibitors

KVARATSKHELIA, MAMUKA

1-Dec-08 $1,125,000 Pending


Reactivation of tumor suppressor genes in breast cancer by dietary supplements as DNA methylation modulators.

LIU, ZHONGFA; CHAN, KENNETH K; HUANG, TIM HUI-MING; MARCUCCI, GUIDO







New curcumin analogues with enhanced growth suppressive activity as novel therapeutic agents for breast cancer

FUCHS, JAMES ROBERT; CHAN, KENNETH K; LIU, ZHONGFA



Novel JAK2/STAT3 inhibitors for pancreatic cancer therapy

LI, CHENGLONG; BLOOMSTON, PAUL MARK; FUCHS, JAMES ROBERT; LI, PUI-KAI; PHELPS, A MITCHELL


Am Heart Assn Development of selective STAT1 inhibitors for vascular inflammatory diseases

HOYT, DALE G; FUCHS, JAMES ROBERT; LI, CHENGLONG; LI, PUI-KAI

1-Jan-09 $150,000 Not Funded


Dual inhibitor design targeting Jak2 and STAT3 via tautomerically defined curcumin analogues

LI, CHENGLONG; FUCHS, JAMES ROBERT; HOYT, DALE G






2008 Annual Report



www.phpid.osu.edu

Appendix G

Am Cancer Soc Inc

Computer-assisted grading of follicular lymphoma

GURCAN, METIN NAFI; FERNANDEZ, SOLEDAD A; LOZANSKI, GERARD; PENNELL, MICHAEL L


EXCMR, Ltd. Exercise stress cardiac magnetic resonance imaging

SIMONETTI, ORLANDO P; ARNOLD, JOHN W; DICKERSON, JENNIFER ANN; PENNELL, MICHAEL L; RAMAN, SUBHA V


EXCMR, Ltd. Exercise stress cardiac magnetic resonance iImaging

SIMONETTI, ORLANDO P; ARNOLD, JOHN W; DICKERSON, JENNIFER ANN; PENNELL, MICHAEL L; RAMAN, SUBHA V


March Dimes Birth Defects Fdn

Pathways to racial and ethnic disparities in preterm birth

IAMS, JAY D; ACKERMAN, WILLIAM E; CHRISTIAN, LISA MICHELLE; LYNCH, COURTNEY DENNING; PENNELL, MICHAEL L

1-Jun-09 $36,120 Pending

Morris Animal Fdn





Preparation to Protect Workers from Infectious Agents: An Influenza Model

BUCKLEY, TIMOTHY J; CASTO, BRUCE C; LEE, CHANG W; PENNELL, MICHAEL L; SAIF, YEHIA M




WANG, DANXIN; KOLETAR, SUSAN L; LEE, MEI-LING TING; PARA, MICHAEL F; SADEE, WOLFGANG


Nat Inst of Dental & Craniofacial Res

Association between remodeling and creep behavior of trabecular bone

KIM, DOGYOON; PENNELL, MICHAEL L



Examining the effect of a provider-delivered intervention among Medicaid smokers

FERKETICH, AMY K; PENNELL, MICHAEL L; SEIBER, ERIC; WEWERS, MARY E



Computer-assisted grading and risk stratification of follicular lymphoma

GURCAN, METIN NAFI; FERNANDEZ, SOLEDAD A; LOZANSKI, GERARD; PENNELL, MICHAEL L; RACKE, FREDERICK KARL


2008 Annual Report



www.phpid.osu.edu

Appendix G


Gender Differences in Lung Cancer: Effects of COX-2 and Aromatase

HARRIS, RANDALL E; BARSKY, SANFORD H; BRUEGGEMEIER, ROBERT W; CASTO, BRUCE C; MOESCHBERGER, MELVIN L; ROSS, PATRICK JR; SUGIMOTO, YASURO



PTEN in the tumor microenvironment of breast cancer

LEONE, GUSTAVO W; FERNANDEZ, SOLEDAD A; HUANG, TIM HUI-MING; OSTROWSKI, MICHAEL C; ROSOL, THOMAS J; YEE, LISA D



Biologic effect and therapeutic potential of STAT3 dysregulation in osteosarcoma

LONDON, CHERYL A; YU, ZHANGSHENG



Identification of factors affecting EMS workers? adoption of MSD interventions

LAVENDER, STEVEN A; CRAWFORD, JOHN M; YU, ZHANGSHENG


NSF Social & Economic Sciences

Analysis of models as innovation indicators and outcomes in engineering education

CHARYTON, CHRISTINE; GUSTAFSON, ROBERT J; JAGACINSKI, RICHARD J; PENNELL, MICHAEL L

1-Sep-08 $19,994 Not Funded






Disabilities and Secondary Injuries among US Working-age Adults

WILKINS, JOHN R III; LU, BO


The Robert Wood Johnson Fdn

Understanding the Relationship between the Nursing Practice Environment, Patient Outcomes, and Efficiency of Care Delivery

SALSBERRY, PAMELA J; DEMBE, ALLARD; NASH, MARY G; PENNELL, MICHAEL L

1-Sep-08 $149,993 Not Funded

Univ of Maryland

Threshold regression methodology for cancer risk assessment

PENNELL, MICHAEL L; HE, XIN


Water Environment Research Fdn

An interdisciplinary study: Rapid detection of fecal indicators/pathogens and risk assessment modeling in a flowing stream primary contact recreational water

LEE, JIYOUNG; ALSDORF, DOUGLAS E; LIANG, SONG; LU, BO; WILKINS, JOHN R III


2008 Annual Report



www.phpid.osu.edu

Appendix G

Centers for Disease Control & Prevention

"Foundations for Healthy Living" Prevention Research Center

WEWERS, MARY E; ANDERSON, SARAH ELIZABETH; BUCKLEY, TIMOTHY J; KAYE, GAIL L; KLEIN, ELIZABETH GARDNER; PIRIE, PHYLLIS L


Emergency Medicine Fdn

An outcomes based assessment of level I and level II trauma centers in the United States

CUDNIK, MICHAEL T.; HARRIS, RANDALL E; STEINBERG, STEVEN M; WHITE, LYNN J


Franklin Co Board of Health

Critical evaluation of a passive epidemiological surveillance and investigation protocol of illnesses reported by neighbors of land application sites of biosolids and other soil amendments

LIANG, SONG; BUCKLEY, TIMOTHY J; WILKINS, JOHN R III


Johns Hopkins Univ

A Randomized Trial of the Combination of Two Universal Preventive Interventions

MURRAY, DAVID 1-Mar-09 $334,745 Not Funded

March Dimes Birth Defects Fdn

Pathways to racial and ethnic disparities in preterm birth

IAMS, JAY D; ACKERMAN, WILLIAM E; CHRISTIAN, LISA MICHELLE; LYNCH, COURTNEY DENNING; PENNELL, MICHAEL L



Examining the effect of a provider-delivered intervention among Medicaid smokers

FERKETICH, AMY K; PENNELL, MICHAEL L; SEIBER, ERIC; WEWERS, MARY E





1-Dec-08 $1,238,166 Pending


Tobacco cessation interventions with Ohio Appalachian smokers

WEWERS, MARY E; FERKETICH, AMY K; KWAN, MEI-PO; MURRAY, DAVID


2008 Annual Report



www.phpid.osu.edu

Appendix G






NCMHD comprehensive center of excellence

PASKETT, ELECTRA D 1-Jul-09 $7,096,892 Pending


Planning to be active: Appalachian adolescent physical activity intervention

PETOSA, RICK A; MURRAY, DAVID






Pfizer Inc Randomized Clinical Trial of Haldol (Haloperidol) versus Geodon (Ziprasidone Melysate) in the Emergency Treatment of Acute Psychotic Episodes of Schizophrenia

RUND, DOUGLAS A; HARRIS, RANDALL E; SAVEANU, RADU V



Disabilities and Secondary Injuries among US Working-age Adults

WILKINS, JOHN R III; LU, BO


The ISA Group Testing the Effects of Personal Contact on Web-Based Stress and Mood Management

MURRAY, DAVID 1-Aug-09 $94,039 Pending

Univ of North Carolina

State-level policies, demographics and behaviors associated with adolescent obesity

MURRAY, DAVID 1-Jul-09 $37,276 Pending

University of Massachusetts Medical Sch

RCT for Smoking Cessation in Medical Schools

MURRAY, DAVID 1-Jul-09 $126,462 Not Funded





2008 Annual Report



www.phpid.osu.edu

Appendix G

Army Does PAH exposure modulate estrogen metabolism to alter breast cancer risk?

BUCKLEY, TIMOTHY J; BRUEGGEMEIER, ROBERT W; CASTO, BRUCE C; DARBY, MICHAEL VINCENT; RUSH, LAURA J



Integrating the Disruption of Neglected Tropical Disease Transmission and Renewable Energy Production with Biogas Digesters




Integrating infectious disease training from lab-based to population scales

SCHLESINGER, LARRY S; BUCKLEY, TIMOTHY J

1-Feb-09 $1,222,972 Not Funded

Centers for Disease Control & Prevention

"Foundations for Healthy Living" Prevention Research Center

WEWERS, MARY E; ANDERSON, SARAH ELIZABETH; BUCKLEY, TIMOTHY J; KAYE, GAIL L; KLEIN, ELIZABETH GARDNER; PIRIE, PHYLLIS L



Irrigation Water Risk Assessment for Enhanced International Competitiveness

LEJEUNE, JEFFREY T; DOOHAN, DOUGLAS; LIANG, SONG


Environmental Protection Agency

Enhancement of methane production by the integration of methanogens for greater potential energy yields in anaerobic waste treatment systems

LEE, JIYOUNG 1-Oct-09 $9,754 Pending

Franklin Co Board of Health

Critical evaluation of a passive epidemiological surveillance and investigation protocol of illnesses reported by neighbors of land application sites of biosolids and other soil amendments

LIANG, SONG; BUCKLEY, TIMOTHY J; WILKINS, JOHN R III


Global Youth Partnership for Africa

Improving public health by integrating rain collection, biogas production, and education to achieve sustainable access to clean water and energy in Bukomero, Uganda



HALO Technologies, Inc

Evaluation of a U-Equipped Vacuum Cleaner for Inactivation of Surface Embedded Microorganisms

BUCKLEY, TIMOTHY J; NEEDHAM, GLEN R

1-Mar-08 $16,279 Awarded

Intl Food Policy Res Inst

Breaking the cycle of disease in rural China through simple treatment systems for agricultural wastewater recycling.

MANCL, KAREN M; LIANG, SONG


2008 Annual Report



www.phpid.osu.edu

Appendix G

Morgan State University

Practical approaches for involving traditionally underserved populations in transportation decisionmaking

BUCKLEY, TIMOTHY J 1-Jul-09 $67,849 Pending

NASA Headquarters

Environmental Risk-oriented Surveillance of Water-related Infectious Disease Based on Satellite Observations

LIANG, SONG; ALSDORF, DOUGLAS E; MERRY, CAROLYN J



Preparation to Protect Workers from Infectious Agents: An Influenza Model

BUCKLEY, TIMOTHY J; CASTO, BRUCE C; LEE, CHANG W; PENNELL, MICHAEL L; SAIF, YEHIA M

1-Dec-08 $1,383,170 Pending


Sleep patterns and work-shifts: enhancing sleep quality of EMTs and paramedics

CRAWFORD, JOHN M; DEMBE, ALLARD; HADE, ERINN MELISSA; MAGALANG, ULYSSES J







A Case Study of Asthma and the Indoor Environment

BUCKLEY, TIMOTHY J; PIRIE, PHYLLIS L







Identification of factors affecting EMS workers? adoption of MSD interventions

LAVENDER, STEVEN A; CRAWFORD, JOHN M; YU, ZHANGSHENG



Protecting Public Health at Ohio Inland Beaches: Development of Water Quality Indicators for Recreational Microbial Exposure

BUCKLEY, TIMOTHY J 1-Jan-09 $190,042 Awarded

Univ of Washington

Detection and reproduction system of microbes via a bio-inspired DNA feeder

LEE, JIYOUNG 15-Sep-09

$395,663 Pending

2008 Annual Report



www.phpid.osu.edu

Appendix G





OH Dept of Health

Public engagement demonstration project on pandemic influenza-rural(initiative B)

BUCKLEY, TIMOTHY J; PEARSOL, JOANNE

10-Aug-08

$200,000 Awarded

OH Dept of Health

Maternal and Child Health Block Grant Five Year Needs Assessment Facilitation

HOLTZHAUER, FRANCIS J


OH Dept of Health

HIV/STD Strategic Planning Project HOLTZHAUER, FRANCIS J; PEARSOL, JOANNE

15-Apr-08

$9,992 Pending

OH Dept of Health

Homeland Security Exercise and Evaluation (HSEEP) Training Project



OH Dept of Health

Training of Public Health Personnel and Public Health Partners in the "Planning P Process" for a Type 3 Incident


1-Mar-08 $129,822 Awarded

OH Dept of Health

Public Engagement Demonstration Projects on Pandemic Influenza

HOLTZHAUER, FRANCIS J; PEARSOL, JOANNE; STANLEY, SHARON A

1-May-08

$399,434 Awarded

Am Cancer Soc Inc

The role of dickkopf-1 (DKK1) in breast cancer bone metastases.

PINZONE, JOSEPH J; RAMASWAMY, BHUVANESWARI; ROSOL, THOMAS J; YEE, LISA D



Novel translation control strategy for junD, a modulator of cardioprotection and hypertrophy

BORIS-LAWRIE, KATHLEEN A


Am Lung Assn Regulation of ion transport and cytokine production by cadmium in the lung

CORMET-BOYAKA, ESTELLE; DAVIS, IAN C


Am Lung Assn Ventilator pressure effects on alveolar fluid clearance and multi-organ dysfunction syndrome in acute lung injury models.

DAVIS, IAN C 1-Jul-09 $80,000 Pending

American Thoracic Society

Effect of ventilator pressure on alveolar fluid clearance and multi-organ dysfunction syndrome following acute lung injury

DAVIS, IAN C 1-Jan-09 $100,000 Not Funded

Army Does PAH exposure modulate estrogen metabolism to alter breast cancer risk?

BUCKLEY, TIMOTHY J; BRUEGGEMEIER, ROBERT W; CASTO, BRUCE C; DARBY, MICHAEL VINCENT; RUSH, LAURA J


2008 Annual Report



www.phpid.osu.edu

Appendix G

Army Identification of intravasation genes from human breast cancer cells

ROSOL, THOMAS J 1-Nov-08 $112,500 Not Funded

Army Tumor-specific metastatic profile of primary human breast cancers in nude mice

ROSOL, THOMAS J 1-Mar-09 $375,000 Pending


Tipping the balance from HIV-1 protein: Potential cure for viral latency


15-Sep-08

$100,000 Pending


Neorickettsia sennetsu: Studies on pathogen and host interactions

GIBSON, KATHRYN E.; RIKIHISA, YASUKO



Manipulation of the respiratory epithelial cell intracellular milieu by influenza and respiratory syncytial viruses

DAVIS, IAN C 1-Jul-09 $500,000 Pending

Cleveland Clinic Immunoisolation of pancreatic xenografts by novel amphiphic membranes

KRAKOWKA, GEORGE S


Kentucky Thoroughbred Association, Inc

Potomac horse fever study for future vaccine development

RIKIHISA, YASUKO 1-Apr-08 $146,802 Not Funded

Lupus Research Institute, Inc

?FUNCTIONAL ANALYSIS OF THE LUPUS AUTOANTIGEN, RNA HELICASE A?


1-Nov-08 $282,956 Not Funded

Merial Ltd A challenge trial conducted in gnotobiotic swine to determine if selected materials used for production of Merial swine biologicals contain infectious torque teno viruses

KRAKOWKA, GEORGE S

15-Feb-08

$46,200 Awarded

Merial Ltd Immunoprevention for helicobacter-associated gastritis in gnotobiotic swine

KRAKOWKA, GEORGE S


Morris Animal Fdn

The In Vitro Effects of Histone Deacetylase Inhibitors on Feline Oral Squamous Cell Carcinoma

KISSEBERTH, WILLIAM C; LONDON, CHERYL A; ROSOL, THOMAS J


Morris Animal Fdn




Morris Animal Fdn

Effect of combined zoledronic acid and piroxicam on feline oral squamous cell carcinoma

ROSOL, THOMAS J; KISSEBERTH, WILLIAM C; LONDON, CHERYL A; MARTIN, CHELSEA K


Nat Center for Research Resources

Interactions of neorickettsia sennetsu and its host in vitro and in vivo

GIBSON, KATHRYN E.; RIKIHISA, YASUKO


2008 Annual Report



www.phpid.osu.edu

Appendix G


Importance of temperature on extrapolating information from laboratory animals to man

HAMLIN, ROBERT L; DAVIS, IAN C; KHAN, MAHMOOD; NELSON, RANDY J



Role of nuclear PTHrP in bone development and hematopoiesis

HILDRETH, BLAKE EASON; ROSOL, THOMAS J; TORIBIO, RAMIRO E



Short Term Research Training for Veterinary Students

OGLESBEE, MICHAEL J






Nat Inst Neurological Disorders & Stroke

Preclinical Toxicity Evaluation of a Potent Oncolytic Virus

CHIOCCA, E ANTONIO; OGLESBEE, MICHAEL J; SAEKI, YOSHINAGA



Adenylyl Cyclase Derivatives for GALT-Induced Immunity

BOYAKA, PROSPER N; CORMET-BOYAKA, ESTELLE

1-Apr-09 $1,818,750 Pending


Nucleotide synthesis inhibitor therapy for hypoxemia in influenza infection

DAVIS, IAN C; CORMET-BOYAKA, ESTELLE



Molecular Determinants of Virulence of the Circoviridae

KRAKOWKA, GEORGE S; JACKWOOD, DARAL J; PAPENFUSS, TRACEY L; RINGS, DONALD MICHAEL

1-Mar-09 $1,500,000 Pending


Heat shock protein modulation of viral virulence

OGLESBEE, MICHAEL J; NIEWIESK, STEFAN; POPOVICH, PHILLIP G

1-Jul-09 $1,687,500 Pending


TYPE IV SECRETION & SIGNAL TRANSDUCTION IN EHRLICHIOSIS

RIKIHISA, YASUKO 1-Jan-09 $1,875,000 Awarded

Nat Pork Board Virulence of genogroup 2 porcine torque teno virus in gnotobiotic swine

KRAKOWKA, GEORGE S



PTEN in the tumor microenvironment of breast cancer

LEONE, GUSTAVO W; FERNANDEZ, SOLEDAD A; HUANG, TIM HUI-MING; OSTROWSKI, MICHAEL C; ROSOL, THOMAS J; YEE, LISA D



Alternative approaches for NALT-based immunity to respiratory pathogens

BOYAKA, PROSPER N; CORMET-BOYAKA, ESTELLE; DAVIS, IAN C

1-Dec-08 $1,781,250 Awarded

2008 Annual Report



www.phpid.osu.edu

Appendix G


Measles Virus Interference with Macrophage Phagocytosis and Bacterial Killing

CARSILLO, MARY ELIZABETH; NIEWIESK, STEFAN



Regulation of ion channels in the lung by the cigarette-smoke component cadmium

CORMET-BOYAKA, ESTELLE; DAVIS, IAN C; DIAZ, PHILIP T; KNOELL, DAREN L



Dendritic cell activation by mitochondrial transcription factor A

CROUSER, ELLIOTT D; MARSH, CLAY B; PAPENFUSS, TRACEY L; TRIDANDAPANI, SUSHEELA



Effects of nuclear parathyroid hormone-related protein (PTHrP) on bone formation and the skeletal microenvironment

HILDRETH, BLAKE EASON; ROSOL, THOMAS J; TORIBIO, RAMIRO E



Virus enhanced cystic fibrosis in transgenic cotton rats

NIEWIESK, STEFAN 1-Dec-08 $440,000 Pending


Dickkopf-1 in breast cancer bone metasteses

PINZONE, JOSEPH J; BARSKY, SANFORD H; RAMASWAMY, BHUVANESWARI; ROSOL, THOMAS J


NexBio, Inc. Testing anti-parainfluenza virus drug NIEWIESK, STEFAN 1-Feb-08 $13,530 Awarded

Susan G Komen Breast Cancer Fdn

Identifcation of breast cancer genes of bone marrow endothelium

ROSOL, THOMAS J; LEONG, JOHN


US Department of Defense

Identification of breast cancer extravasation genes of bone marrow endothelium

ROSOL, THOMAS J 1-Sep-09 $112,500 Not Funded


Biological and chemical public health hazards of swine lagoon water crop spray and manure applications

GEBREYES, WONDWOSSEN A; HOET, ARMANDO E


Higher Education for Development

Capacity Building in Veterinary Public Health: Center of Excellence in Zoonosis, Molecular Diagnostics and Geospatial Health

GEBREYES, WONDWOSSEN A; HOET, ARMANDO E; SILVEIRA, FERNANDO; WITTUM, THOMAS E


Kenneth A Scott Charitable Trust

Access to Quality Companion Animal Care in Underserved Areas

LORD, LINDA KAY; HILL, LAWRENCE N


Morris Animal Fdn

Effect of cage enrichment and predictability on health outcomes of shelter cats

LORD, LINDA KAY; BUFFINGTON, CHARLES A


Nat Pork Board Genotyping of campylobacter coli in pigs from farm to fork

GEBREYES, WONDWOSSEN A; WITTUM, THOMAS E

1-Nov-08 $4,100 Awarded

2008 Annual Report



www.phpid.osu.edu

Appendix G

Nat Pork Board Prevalence and characterization of Methicillin Resistant Staphylococcus aureus (MRSA) in pigs and farm workers on conventional and antibiotic free swine farms in the USA.

GEBREYES, WONDWOSSEN A; HOET, ARMANDO E


Nat Pork Board Nasal and fecal carriage of methicillin resistant staphylococcus aureus (MRSA) and other staphylococci (MRS+) on farm and slaughter and risk to pork safety

GEBREYES, WONDWOSSEN A






North Carolina State Univ

An Integrated Approach to determine Salmonella dynamics in the niche-market Antimicrobial-Free Swine Production System

GEBREYES, WONDWOSSEN A


OH Dept of Health

Educational program initiative to prevent the emergence and spread of antimicrobial resistance

HOET, ARMANDO E 1-Sep-08 $14,950 Awarded





Univ of Minnesota

Prospective Epidemiological Investigation of Interspecies Transmission of Influenza A Virus Infections at Wild Bird-Captive Bird Interfaces

SLEMONS, RICHARD D; DENNIS, PATRICIA M


Univ of Minnesota

MCEIRS influenza A virus research network in wild birds: adding study sites in gaps along the Mississippi Migratory Bird Flyway

SLEMONS, RICHARD D; GIBBS, H LISLE

1-Aug-08 $446,677 Awarded

USDA Agricultural Res Service

USDA CSREES national needs graduate fellowship program

RAJALA-SCHULTZ, PAIVI J; WITTUM, THOMAS E

3-Nov-08 $257,994 Not Funded

$123,395,687

2009 ANNUAL REPORT - Office of Academic Affairs

Documents

Transcript of 2009 ANNUAL REPORT - Office of Academic Affairs