CALIFORNIA TUMOR TISSUE REGISTRY

"GENERAL PATHOLOGY"

Study Cases, Subscription A

March 2006

California Tumor Tissue Registry c/o: Departmeot ofPatbology and Human Anatomy

Loma Linda Univenily School of Medicine 11021 Campus Avenue, AB 335 Loma Linda, Califoraia 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: cm@linkljne.corn Web page: \\Ww.cur.org

Web site & Case of Cbe Month: www.cttr.org

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Target audience: Practicing. pathologists and pathology residents.

Goal: To acquaint· the participant with the histologic features of a variety of benign and

malignant neoplasms and tuino.r-like conditions.

Objectives: The participant will be able to recognize morphologic features of a variety of benign

and malignant neoplasms and. tumor· like conditions and relate those processes to pertinent references in the medical literature.

Educational methods and media: Review of representative glass slides with associated histories. Feedback on consensus diagnoses from participating pathologists. Listing of selected references from the medical literature.

Principal faculty: Weldon K. Bullock, MD Donald R. Chase, MD

CME Credit: Lorna Linda University School of Medicine designates this continuing medical

education activity for up to 2 hours of Category I of the Physician's Recognition A wand of the American Medical Association.

CME credit is offered for tile subscription year only.

Accreditation: Loma·Linda University School of Medicine is accredited by the Accreditation

Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.

Study Cases, Marcb 2006, Subscription A

Contributor: Carol Solomon, M.D. Case No.1 - March 2006 San Diego, CA

Tissue from: Liver Accession #30011

Clinical Abstract: This 2 year old boy was found to have a right upper quadrant mass.

Gross Pathology: The resected right lobe of liver contained an 1 1 x 6 x 5 em well-circumscribed nodular mass

with a heterogeneous gray-yellow cut surface showing foci of hemorrhage and necrosis.

Contributor: Lauren O'Brien, M:D. Case No. 2 - March 2006 Pasadena, CA

Tissne from: Liver Accession #30003

Clinical Abstract: Because of stomach pain, the 68 year old woman underwent and ultrasound and then a CT,

which showed mass in the right lobe of her liver.

Gross Pathology: The 240 gram, 13 x 8 x 52 em portion ofliver had a 5 x 4.8 x 4.8 em tan to slightly green mass

with a central scar and a multinodular array around the center.

Contributor: Naif Abraham, M.D. Case No. 3 - March 2006 Syracuse, NY

Tissue from: Lung Accession #29999

Clinical Abstract: For two years this 56 year old man had been followed for a pulmonary nodule. After he

presented with hemoptysis, he underwent resection of the mass.

Gross Pathology: Within the 5 em diameter portion of lung was a 4 em oval, well-defined white nodule with a

gritty cut surface.

Contributor: JozefKollin, M.D. Case No. 4 - March 2006 Lakewood, CA

Tissue from: Mediastinum Accession #30067

Clinical Abstract: A routine chest x-ray disclosed a mediastinal mass in this 70 year old man.

Gross Pathology: The 6.7 em encapsulated mass had fibrous septa traversing its gray-tan cut surface. There were

no gross foci of bemonhage or necrosis.

Contributor: Xuedong Wang, M.D. Case N0. 5 - March 2006 Pasadena, CA

Tissue from: Left adrenal gland Accession #30051

Clinical Abstract: During a work-up for intractable vomiting, this 39 year old man was found to have a 5 em

adrenal mass. · Screening studies "rul.ed out pheochromocytoma", while urinary free cortisol levels were elevated at about 1\vice the normal concentration. The patient did not have symptoms of Cushing's syndrome.

Gross Pathology: About half of the resected adrenal gland was replaced by a rounded, 4.8 em, non-infiltrative,

uniformly brown mass, without m:eas of hemorrhage or necrosis.

Contributor: JozefKollin, M.D. Case Ne~. 6 - March 2006 Lakewood, CA

Tissuefrom: Right adrenal gland Accession #30052

Clinical Abstract: An 83 year old man was found by CT scan to have a large right adrenal mass. A "hormonal"

work-up was negative, showing no evidence of endocrine or neuroendocrine expression. At surgery, a vascular fibrotic process involved the vena cava and renal v.ein and appeared to invade the liver.

Gross Pathology: A 1,265 gm, 20 x 14 x 10.5. em necrotic hemorrhagic tumor completely replaced the adrenal

gland.

Svecial Studies: CAM5.2 SlOO Chromogranin A EMA lnhibin MelanA Synaptophysio

negative negative negative negative focally positive focally positive positive

Contributor: Xuedong Wang, M.D. Case No. 7 - March 2006 Pasadena, CA

Tissue from: Right kidney Accession #30007

Clinical Abstract: After complaining of indigestion and abdominal cramps for about a month, this 54 year old

woman was found to have a slightly elevated Cl25 of 41 (ref. range 35). ACT scan showed a heterogeneous mass in the region of the right adrenal or kidney. An MR1 showed a solid mass in the upper pole of the right kidney, displacing the right adrenal superiorly.

G.ross Pathology: The right kidney contained a 5 x 5 x 4.5 em well circumscribed yellow-tan mass in the upper

pole.

Special Studies: Desmin Actin HMB45

negative focally positive focally positive

Contributor: Pamela Boswell, D.O. San Diego, CA

Tissue from: Right kidney

Clinical Abstract:

Case No.8 - March 2006

Accession #30055

During work-up for a urinary tract infection, physical ·exarnination ofthis 53 year old woman revealed hepatomegaly. An ultrasound showed gallstones but no enlargement of the liver. At the same time, a heterogeneous, hypoecboic oval mass was seen displacing the right kidney.

Gross Pathology: The 1,500 gram, 22 x 14.5 x 10.5 em retroperitoneal mass had a smooth, glistening outer

surface. The cut surface was variegated yellow and dark red-brown, with small foci of apparent bone.

Contributor: Mark Janssen Anaheim,CA

Tissue from: Small bowel

Clinical Abstract:

Case No.9 - March 2006

Accession #30091

During prostatectomy for adenocarcinoma, this 53 year old man was found to have a nodule on the small bowel.

GrosS Pathology: A U-shaped loop of small bowel had an 8.5 x 7.0 x 6.5 em mass at its mesenteric border. The

cut surface showed hemorrhagic cystic changes. There was no connection between the mass and the small bowel mucosa.

Special Studies: CD34 CD117 Des min Cytokeratin

strongly positive strongly positive negative negative

Contributor: Robert Bates, M.D. San Antonio, TX

Tissue from: Left knee

Clinical Abstract:

Case No. 10 - March 2006

Accession #30092

While he was driving, a 37 year old man noticed a mass behind his left knee.

Gross Pathology: The 122.3 gram, 8 x 7 x 4.5 em portion of rubbery gray-brown tissue appeared to have been

shelled out from its site. The cut surface showed a thin fibrous capsule and a multinodular architecture.

Soecial Studies: CD34 SLOO EMA Smooth muscle actin Desmin

positive negative negative negative negative

CALIFORNIA TUMOR TISSUE REGISTRY

GENERAL P AI'HOLOGY

Minutes - Subscription A

March, 2006

SUGGESTED READING (General Topics from Recent Literature):

Endosonograpbic Diagnosis of Recurrent Gastrointestinal Stromal Tumors Associated with Carney's Syndrome. Llpcan MT, Loren DE, Palazzo JP, et al. Gastroenterology 2005; 128:169-174.

PSA Testing. What is the Use? 17te Lance/2005; 365:1447-1449. Epithelioid Mesotheliomas vs. Pulmonary Squamous Cell Carcinomas. Ordonez NO. Mod Patho/2006; 19:417-428. illtrasensitive PSA Nadir Can Predict Recurrence. Nakamura M, Hasumi H, et al. lnt J Uro/2005; 12:1050-1054. EUS-FNA Useful in Gastrointestinal Lesions. Bardales RH, Stelow EB, eta!. Diagn Cytopatho/2006; 34:140-175.

Nineteen days after suffering a major heart attack and a fal l, Dr. Weldon K Bullock died at his new home at Linda Valley Vil)a (Loma Linda) on March 28,'2006. He W"-198-years-young and \\;II be deeply missed. Please say a prayer of thanksgiving for his wonderful and amazing life.

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: cttr@linkline.com Web site & Case of the Month: www.cttr.org

Case 1:

Case 2:

FILE DIAGNOSES

(Preferably submilled on website at www.cttr.org. Click "subscriptioos", then submit answers".)

CTIR Subscription A

Hepatoblastoma, right hepatic lobe T-56000, M-89703

Hepatocellular carcinoma, right hepatic lobe T-56000, M-81703

March,2006

Case3: .

Case4:

CaseS:

Case6:

Case 7:

CaseS:

Case9:

Chondromatous pulmonary hamartoma T-28000, M-75500

Thymoma, mediastinum T-Y2300, M-85800

Adrenal cortical adenoma, left adrenal T-93000, M-83700

Adrenal cortical carcinoma, right T-71000, M-83703

Angiomyolipoma, right k.idney T-71000, M-88600

Myelolipoma, adrenal T-Y4600, M-88700

Gastrointestinal stromal tumor (GIST), small bowel T-64000, M-88903

Case 10:

2

Hemangiopericytomalsolitary fibrous tumor, lower extremity T-Y9220, M-9051 0

C."'ri'R, Man:h 2006 " Minutes" (Subsaiplian A)

Case No. I , AcassioD No. 30011

Alameda !Alameda County Medical Cal!ql • tlcpatoblastoma Alameda !Garfield Ma!ical CenJ&rl • Hcpolocellular carcinoma !!Aldwin l'1lrlt <Kalsq l'ymancntcl · Hcpolobla.toma (3) Fontapa !Kaiser Pgmanepte!Iospital) • Hcpolobla.'lloma ~ • Hcpolobb!sloma Hmpn!lftemont <St. ROllO H05!!itall · Hq>a!Oblastoma with !lMli !Mpe runivmity ofCa!ifomja Irvine) • Hc:potoblastoma !&mlJ,inda ctoma Linda 1/njvmity Medical Center Pathology Rcsjdent<;l • Hcpotoblastoma bona !lcacb n J!keyrond Regional Medical Center> . Hepowblastoma (I 0) Monterey Parle: <Monterey I'euinsula Pal!!olosj!!l.:!) • Hepotoblastoma MOUD!Ijn View lEI Camjno Pt!hology\ • Hcpoloblastoma 9ranoc !Onmge County Medical Group) • Hepotoblastoma Oman! !St. John's Rcgio!!Jl Medical Ccnlq) • Hq>a!Oblastoma (3)

Marcb2006

Sm Oieso (Naval Medical Center) • Hc:potoblastoma, epitbcliallype with fda! and cmbcyonal ponems ( l ); Hepo!Oblastoma ( l) SP!!A Bad!wa CCo!Jaac Hospi!all - Hepotoblastoma San flllncisco !San FJMCissl Gcnml HOSpjtaD • Hcpatoblasloma Santa Rosa <Sa•t• Rosa Memorial HOS!lita!l - Hcpotoblastonuo (a) Ventu!ll OJNILI\Bl • Hepotoblastoma Woodland Hills !Kaiser Psrmancntc Medical Center! - Hepotoblastoma (2); ExtrarncduiiQI)' hcma1opocisis Mztw Nnivmity ofA!bnsas Medical Ceol<J) • H<:palobl..aOma Co!orJdo £!!2l!!\X!! • ·~blastoma flcrida U"im9 MemariaJ HOS!>ila!) - llepotoblastoma florida. Tallah"'N"t · Hepotoblastoma f!Qrida Cl'he Pathology Groyl!) - Hepotoblastoma (5) f lorjda !Winter Haven Uo:;pj!all · Hcpotoc::ellular carcinoma lllinojs CNml Hospil4! Cm;at Lakesl • llepotoblastoma Dljngjs. Oak Broolc - Hepotoblastoma !lligojs !Loyola UniV<nity Ma!ica! Center) • Hq>a!Oblastoma lndjp !Ball Mm>orW Hospital) - Hepatoblastoma

• Jndjana fKoltamo Pa!bo!gsjst Health Svstcml • Hcpotoccllular carcinoma Ken!ucky I!Jniversity ofl.9ujsyille Hospi!ll!) • Hcpatoblastoltlll, fc!al type Mlryland <NatiOOaJ Naya! Mg!jcal Center) • I·I•'J)Aloblastoma Maryland CNorth'm'frn Hospital Ceo!Cr) - liepotoblastoma MIN!and Nnivmity of Maryland) - Hepotoblasloma H hUSdiS tNcw llns!apd Medical Ccntq) - HepotOblastoma Midljgn COakwood t lospita!l - Hcpatoblastoma Mjnn""'* CFairvicw Rjdaes llospitall • llepowblastoma Nr!vps•• !Cn:i@ton UnjyeQjty School ofMg!jcjne) - Uepotoblostoma, fetal type (8); vs. infuntilc hcpalO<lCIIvlar carcinoma (2) New York fi&n• Island Jewish Medical Center\ • Hepatoblastomo. feW type New York !NaSSau Univc[$jty Medical Cen!Cr) - Hcpatoblastoma, •-mbryooic type New Yor!c CNcw Y or!< Stony Brook Uniyqsjty Hospital Resida!Jsl - Hepatoblastoma New )'or!< !SUNY Oowns!a!c .R'"'ii"rn!Sl • Hc:potoblastoma New Yorit twrgrhes'er Medical Ceoterl - Hcpatoblastoma, epithelial type North Carolina fMoonlljn t\tsa Pa!bology) • Hepatoblastoma (3); Hcpotoblastoma. fel4! 'r.lriant (2) Ppmsylmja IConemau•h Memorial Mg!jeal Center) - Flcpatoblastoma Penn"Yiyania CM!. Ni!W!y Medical Center\ - Hepotoblastoma

IP§C!!!!Sy~lyaruag~· !cp!ironsy~!~m~ja;l;iiosp~i!ll!~R;es.l1.dcn~!§~l~~- U~epat~ oblastoma earejnoma

Hepatoblastoma, embryoaai epithelial type (!)

• Hepatoblastoma • Hepatoblll'!!oma

West v irginia /Wetzel Coonty Hospil4!) - Hepotoblastoma Wisoonsin !Bellin Health! • Hcpoloblastoma Wil!oonsjp <Meriter llosnj!a!l · Hepotoblastoma Y?l!Y!min IPll!bo!ogy Amri!!lr<) • Hepoloblastoma (2) AUl!!!Jia <North Old Patho!otty Group! • Hepotoblasloma AUS!JIIia fRoya! Hoban H""Pil4!l - Hepotoblastoma (fi:tal type) III!!IJ!IIia fRol'l!l Prince AJ!jl;d Hospital) - Hepotoblastoma A!Sj!llllia fSullivan Nicolajdes !'l!thology) • Hepotoblastoma GermWiy CUKE. KcrminstiM fur Pathologjel • Hepatoblastoma

3

Ireland IKcny General H!!S!!itall • tlcpatoblastoma Jamaica !The Unjyqsity of !he West Indies) • Hq>a!Oblastoma JaJ)8!! (J(yoto llnjvCJllity Hospital) • liepatoblastoma Japan <Nagoya Uojvc:rsity School ofMC!iicine) - Hcpatoblastoma New ZCaland <Otogo Diagnostic Labl - Hepatoblastoma Puerto Rico CUnlvcr.~itv of Puerto Rjeo School ofMedicjnel · Hcpatoblastomu Saudi Arabia <Kin• FabadNational Gulltd Hospital) • l·lcplltoblastoma Qatar <Hamad Medical Corporntionl • llepatoblslomo

Case 1 - Diagaosio: Hepatoblastoma, right hepatic lobe

T-56000,M-89703

AFfP Consultation: ~Hepatoblastoma, epithelial type, with fetal and embryonal growth."

Case I References: Abbasoglu L, Gun P, Tansu SF, Relik A. et al. Hcpatoblastoma in Cbildron. Acta Chir Belg 2004; 104(3):318-321. Choudhury SR and Singll D. Advanucd licpatoblstoma. Suooessful Liver Resection Following l'reopemtivc Chemolhcmpy. Trop

Gnstroentero/2004; 25(1}:32-33. • Albn:cbt S, Hw1mann Wand Houshdanul f'. Allelic Loss But Absence of Mutations in the Poly:;pecific Transporter Gene. BWR!A

on II pi S~ in tlcpatoblastoma. lnt J Concu2004; 10: 111(4):627-632. HanifG. Intra-Abdominal Tumor.! in Cbildn:o. J Col/ Ph)lskiturs $Jug Pok 2004; 14(8):478-480. Hiyama E, Yamaoka H. Matsunaga T, ct al. Higll Expression ofTelotncrtlsc is an lndepe»dent l'rogoostic Indicator of Poor Outcome

in Hepatoblastoma. BrJ CMctr 2004; 91(5):972-979.

Case No. 2, Acxession No. 30003

AI!U!!OOa /Alameda Countv Me!lica! Center) • Hepatocellular carcinoma Alameda <Garfield Me!ljcal Center) • Hepatooc!lular carcinoma

Marcb2006

Baldwio Park (Kaiser Pcrmancntol • Well-differentiated hcpuloccllular carcinoma (I); Hepatocellular CllJ'I'inoma (2) Fontana IKajSI.T PermaneoteHO>llila!l • Hepatocellulllf carcinoma Glenda)c - Hepatocellular carcinoma Havward/Fremopt ISL Rose Hospitall · Hepatocellular carcinoma lrvinc (l!njmty ofCalifomU. Irvipcl • Hcpatooellular carcinoma in abscn<x: of cirrhosis Lorna IJnc!a O.oma Linda Vpivmity Medical Center Pll!hology Residep!S) - Focal nodular hyperplasia L.ong Bca<:h l!.akcwoo<l Regional Medical Center) - Hepatocellular carcinoma ( I 0) Monterey l'nrk /Monterey Peninsylu Pathologists) • llepliiO<-ellular carcinoma vs. focal nodular hyperphl•ia Mountain View IE! Camino P!l!bo!ogy) • Hcpatocellutor carcinoma Omnse COrun•e Countv Medical Group) • Hcpatooellular cartinoma Oxnlltd ISL John's Regional Medical Center> -Focal nodular hyperplasia (3) San Diego <Naval Medical Cco!Ul • HcpalocciJular carcinoma, NOS (2) Santa Bar!!ora tCott•er Aospjta!J - Hepatocellular carcinoma, gmde 2 San Fnmcisco ($an f@Dcisco General HOS!litall • Hepatocellular carcinoma Santa Rosa ISan)a Rosa Memqrial Hospiudl • Hepatocellular carcinoma (3) Ventura IVNII,ABl • Hepatocellular carcinoma \Yoodland Hills !Kaiser Pcrmanenu: MedjcaJ Center) • Ucpatocel!ular carcinoma (2) ~ ltlpjycrsi'Y of Arlg!nsa:! Medical Center! • Hepatocellular carcinoma Coloradp. EY<!I!!t!C!! - HepoloCcllular C81Ciooma Fk>rida (Jaclgon Memorial Hospital) • Hepatocellular carcinoma florida Tallah...,.. • Hc:patocellular carcinoma Floric!a !The Pathology Grouol • Hepatocellular carcinoma. fibrolamcllar type (S) florida (Winwr Haven Hospital) • Hepntuccllular carcinoma !llioois (Naval Hm ital Great la!ccsl • Hepatooellular CIIICinoma lllinois, QaJs Btoo!c • Hepatooc!lular carcinoma Illinois I Loyola Univasity Meclical Center) • Hepatocellular can:inoma Indiana <Ball Mqnorial Rospi!J)) • llepatocellulorcorcinoma Indiana IKo!samo Palhologjst Health Systqnl - Hepatocellular carcinoma Kentucky lUnjvcrsity ofL.ouisville llosojtall · Hcpa!OCcllular carcinoma Maryland <National Naval Medical Cg•tcrl • Hepatocellular carcinoma (I 0): Hepatocellular carcinoma, l.ibrolwncllur vurinnt fl)

4 CTJ'R, Mordl2006 "MiniiO:$" (SUb!<riptioo A)

MJMand !Nonh!l!e.<!e!l! Hosoita! Cenu:rl - HCI)OIIOCellular carcinoma Myy!and CUniyqsjtv ofM!I!y!andl - Hcpa!OCdlular carciJloma, clcocod.llype !.'•m•hu...ns CNew llnsland Medical Center> - llepatocellular carcinoma Mjchj!r!IJ! CQakwood Homita!l - HepatocdluJar carcinoma Mjnnesgta rFairvjew RjdRc.5 Hll5!ritall - tlcptU<:cllular carcinoma NebMJca <Creighton Unjyersity School ofMcdicin~) - Hepatocellular carcinoma Hew \'od< <Long Island lewi-<h Medical Center\ - Hepatocellular carcinoma New W <Nessm Uojysndtv Medical Cmtru p HcpalOC:ellular carcinoma New Yodc (New Yort Stony Brook Uniyqsjtv Hospital Rcsidcnl$1 - Uepatoccllulat carcinoma. Hew York <SUNY Dom•arr Brsjtlmts) .. Hepatic oeU c:an;inoma New York (Westcl!es!q Medical Cen!Crl - HcpaiO<lellular carcinoma N!!Jib Carolina <Mounll!jp Area Palbology) - Bcpatocdlular c:atcinoma, fibrolamtllar (4); HepatDCCIIular C8T(:inoma (I) Pcnnsvlyanja CConcmauBI! Mgnoria! Medjcal Ccn\erl - Focal nodular hyperplasia Pennsylvania CML Njaany Medical Cent<rl - Clear edl hepaiOCcllular carcinoma Pennsylvania <PcnnsylYI!Jja Hosoilal Residents) - Focal nodular hyperplasia Ter l.ubboct - tlcpetDc:dJuJar carcinoma Tnr IProoa!h Amd"'tV - Hc:pa10e>:llular car<u-.a (2) Tcx~t~ !Wilford Hall Medical Center) - HcpaiAJcellular carcinoma TCXM !Scott & White Memorial Hospitall - J.icpaiAlceUular carc:io<1ma Wc:s! yjmjoja 19rrenbriq Yullcy Me<lical Center! - HepalOCCIIular carcinoma West virginia IWett.el County Rospi!a)l - Fibrolarncllar hepatocellular carcinoma WI$9Q!!Sin <Bellin Hc:althl - Hcpa~AlcelluJar car<u-.a Wjscoosjn (Merita Homjtall - HepatU<:ellular carcinoma Wjlsomin !Pa!!Jology Amd!I!CS) - Hepatocellular carcinoma A!Lllrl!!ia CNo!lh Old Path9!ogy G!!!!JD) - Hepalie adenoma with atypia Australia (Royal Hobart Hospita!J - Hepatocellular carcinoma AusruUa (Royal Prince Alfn;d Hospital\ - Mixed hepatocellul!lf carcinoma and cholnngiocarcinoma (4); l·lcpatoccllular carcinoma (4)

Aystnlia <Sullivan Nicolaides J>arhologyl - Hepatocellular carcinoma Gqmapy <UK£. Kqminllitut fur Pa!ho!ogicl - Hepatocell azcinoma !tdapd (l{qry GcnmJ Bosoitall - Hcpa!OCdlular carcinoma with clear ociJ areas Jomajca !The UilivmiiY of!he West Indies) - Hcpaloedlular carcinoma. fibrolamellar variant Jlp!Ul <Kyoto Univcrsitv Hosojtnll · Hepatocellular carcinoma Japap INJ189va IJnivcnily School of Medicjncl - HcpaiAJcellular curciooma New Zealand IOtago Piwmoslic Lab\ - Hepatocellular carcinoma, moderately-lo-well difterentiated PuertO Rico CUoivasity of Puerto Rico Scl!ool of Medicine) - Liver cell earcinoma (arising from focal nodular hyperplasia?) Sondj Ar!bja OOno Fahad National Guar!l Uo:;pilall - Hcpa!OCdlular carcinoma, libromellartype !lmr fHarnad Medical Corporation) - Hepatocellular carcinoma

Cut 2 - Diaenosk: Hepatocellular carcinoma, right !tepatic lobe

T-56000, M-81703

ev 2 - References: 1!-.g Sl,Luo JC, Li CP, et al Thromhocytosis. A Paraneoplaslie Syndrome in Palicnts wilh HcpaiO<lellular Carcinoma World J

GostroenJero/2004; 10(17): 2472-2477. Vanna V and Cohen C. Immunohistochemical and Molecular Mnrlcers in the Diagnosis of tlcpaiOCCIIular Curcinoma. ildv Anal

Patho/2004; 11 (5):239-249. Si MW, Thorson JA. Lauwcr.; GY, e1 al. t lcpato<>cllular Lymphoepithelioma-Like Carcinoma Associated with Epstein Butr VIrus.

A tlitbeolo UnreooS"izl:d Entity. Diagn Mol Potlto/2004; 13(3): 183-189. Hopi H, Pineau P, 1iollais P, et al Comprcheosive Allelot»>ing of Human HepaiOCellular Carcinoma. Oncogen 1997;

14{24):2927-2933. Plen!z RR, Casditz M. Dieck JS, ct a!. Hepatocdlular Telomc:rc Shortening Correlates wilh Chromosomal Instability and the

Development of Human Hepatoma flepotology 2004; 40(1):80-86.

Case No. 3, A«essioD No. 29999

Namcda CAian.eda Couocy Medical Comer) - l'ulmonaJ)' hcmlltlomn AIJ!mL'!!a !Garfield Medical Center! - Chondroid hWllllrtoma

CTI'R, Man:il2006 "Minutes" {Sub$crip0on A)

March 2006

s

Baldwin Parlt !Kaisa- Pc:nnonen!el - Pulmoruiry hamartoma (3) Fontana (Kaiser Pennanentc Hospital) - PulmonllJ)' hamartoma Glendale - Chondroid hamartoma I!aywan!/Fremont !St. Rose Hospiodl - PulmonllJ)' hamartoma Irvine IUnive!SilV of California Irvine) - Cartllaginous hamartoma Lorna Linda (Lorna Linda Universitv Medical Center Pathology Residents) - Chondrosan:oma, grade I Long Beach flake wood Regjona! Medical Center\ - Chondroid hamartoma (I 0) Monterey Parlt <Monterey Peninsula PalhologiS!Sl - PulmonllJY hamartoma Mountain View lEI Camino Pathology) - Hamartoma Orange COran&e County Medical Group) - Hamartoma O?lnartl !St. John'SResional Medical Center) -Chondroid hamartoma ( I); P\llmonllJ)' hamartoma(2) San Diego !Naval Medical eenter) - Pulmonary hamartoma (I); llrochial hamartoma (I) Santa Barbaia {Collage Hospjtall - l'olmoDilJY hamartoma. San Franci<eo {San Fr.Uleisoo General HO§!!iodl - Polmonary hamartoma Santa Rosa CSMta Rosa Memorial .Hospiod) - Hamartoma (I); Polmonary hamartoma (2) Ventwa{uNlLAB) - Chondromatous hamartoma Wood)and Hills <Kaiser Pcrmanentc Mes!ical Center) - Polmonllly hamartoma ( 1); l'ulmoDilJY chondromatous hamartoma (I) Arlamsas CUnivetSjtv ofArkllnsa.< Medical Ccnterl - Chondromatous hamartoma, lung

·Colorado. Evj;rl!n>:n - -~lamartoma • Florida <Jackson Memorial Hospiodl - Bronchial hamartoma Florida. Tallahassee - Pulmonary hamartoma Florida fThe Pathology Group) - PulmoDilJ)' hamartoma (I); Hamartoma (4) florida <Winter Haven Hospital) - Chondromatous hamartoma TIIinois CNaval Hosojtal Great Lakes) - Polmonlll)' hamartoma Illinois. Oak Brook - Chondroma Illinois !Loyola Univasity Medical Center\ - Chondromatous hamar1oma lndianallla!l Memorial Hosoital) - Pulmonllly hamartoma lodjana CKotguno Pathologist Health System\ - Chondroma Kentucky !University of l.ouiftille flosoital) - Pulmonllly hamartoma Marvland /National Naval Medical Cen(erl - l'ulmoDilJY hamartoma Man1and /Northwestern Hospital Cen!q) - PulmonllJY hamartoma Marvland CUniyetSjty of Maryland) - Hamartoma Massachusclls /New England Medical Center) • Hamartoma (lung) Michigan {Oakwood Hosoiod) - Hamarmma M'mnesota (fairview Ridges Hosoiodl - Cilondroid bamartoma Nebraska {Creighton Uniyet#ty School of Medicine) - Cartllageoous hamartoma New Yorlc <Long Island Jewish Medical Cet!ter) - PulmoDilJY hamartoma New York IN"W" Unjversftv Medical Center) - Pulmonllly parenchymal hamartoma, chondromatous New York (New York Stony Brook University Hospiod Residents) - Hamartoma New Y ad: !SUNY Downstat<: ResjdsniS) - Hamartoma New Vorl< (Wes!Chester Medical Center) - Chondroid bamarloma North Carolina <Mountain Area Pathology) - Hamartoma (2); Bronchial hamartoma (3) Pennsylvania {Conemaugh Memorial Me!lical Center) • PulmoDilJ)' cartllage hamartoma Pegoft!vania fMl Niuany Medical Center) - Pulmonllly hamartoma Pcnnsvlvania <Pennsylvania Hospital Re.sidentsl · Hamartoma TCX!IS, Lubbock - Hamartoma Texas !Propatb Associates) - PulmoDilJ)' hamartoma (I); Polmonary cartilagenous hamartoma (1) Tsxa.s CWilfMd Hall Medical Center) ~ Pulmon8J}' bamartomn Texas {Scott & White MC!I)Qrial Ho@iod) - Pulmonary hamartoma West Virginia (Greenbrier Valley Medical Center) - Hamartoma West yjroipia IWet?.el County Ho@itall - Chondromatous hamartom~ WiS>OOnsjp !Bemn Health\ - Hannartomn Wisconsin fMeriter Hosoiodl - Pulmonary hamartoma Wi<eonsin (Pathology Associates\ - Pulmonllly hamartoma (2) Au.<tmlia <North did Pathology Group) - Chondroid p<JimODilJ)' hamartoma Australia (Royal Bobar! H0<11itafl - Pulmonlll)' bamartoma (adenochoodroma) Australia <Royal Prince Alfred Hospitall - Pulmonary hamartoma Australia !Sumvao Nicolaides Pathology\ - Pulmonary hamartoma Germany CUKE. Kerminstitut for Palholo•iel - Chondroid hamartoma Ireland (Kerrv General HospitJill - Adcnoehondroma (hamartoma) Jamaica CThe Uniymity of the West Indies) · Hamartoma Jaren (Kyoto Univcrsitv Hosoitall - Pulmonary hamartoma JftJ)M <Nagoya llniversity School of Medicine) - Bronchi.a.l hamartoma

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tkw Zeal8J!d !Otago Di!!!!!lO<!jc lab) - Puimolwy luunartoma J>ucrto Rioo I!Jnivcrsjty of Puerto Rjoo School of Mcdicjoe) - Chondroid hamartoma Saudi Arabia !King Fahad National Gu!U'd Hospi!nll - Pulmonary hamartomn 9Mar<Hama4 Medical Corporntionl - Pulmooary bamartoma

C•se 3- Diagnosis: Chondromatous pulmonary hamartoma

T-28000, M-75500

Case 3 - References: Lien YC, Hsu HS, Li WY, et al. Pulmonary Hamanoma. J Chin Med Assoc 2004; 67( 1):21-26. Sllinlali M, Kobayashi H, Kaooh S. ct Ill. Pulmonary HamanomL Unusual Radiologic Appca11111ce. J 7'horac Imaging 2004;

19(1 ):33-40.

Kayser K, Ounnwold 0, Kuzmier=Jc 0, ct al. Chromosomal Aberrations, Promes ofll•pn::ssion ofCirowth-Rclatcd Marker.; Including Cialcctins and Environmental Hazards in Relation to the Incidence of Chondroid Pulmonary Hamartomas. Path<>/ Res Pract2003; 199(9):589-598.

Gregori-Romero MA. Lopcz-Gioes C, Cenla-Nicolas M, d al. R=mbinalions ofChrolnooomal Bands I Oq24, 12q 14-q 15. and 14q24 in Two Cases orPulmonaty Chondroid Hamartoma Studies by fluorescence In Situ Hybridi:cation. Cancor Genet Cytoge1Ult2003; 142(2):153-157.

Rossi G, Cavazza A, Valli R, et al. Atypical Lipomatous Tumour (Lipoma-l..ikc Well-Differentiated l..iposarooma) Arising in n Pulmonary Hamanomaand Oinically Presallin& with Pncumotbo= Lwrg Cancer 2003; 39(1):103-106.

Case No. 4, Accession No. 30067

Alwneda !Alameda County Medical Center) - Thymoma Alameda IOnrfield Modica! Center) • 'lbymoma Baldwin Parle ()(•i...,. Pqmapente) • Spindle cell thymoma (3) fontana !Kaiser Pcnnancntc flomjtall - Thymoma Olcn<la!e - Thymoma, invasive Hayward/Fremont ISL Rgse Hosoita!) • Tbymoma, mixed (All) lrvjne OJnivccrity ofCaljfomia Irvine\ - Thymoma 1.!Jtm Linda ll.om& Uncia Uojversity M!!!ljca! Cen!tr Pa!Do!ogy Residents) • Thymoma l,ong Rgcl! QaCWO<ld Regional Medical Cent&rl • Thymoma (I 0) Monterev Pads (Monterey Peninsula Po!hologisL~) • l"hymoma, type AB Mountain View fill Camjno P!ltholocyl - Thymoma Onmre IOranec Coun!Y Modical orpup> - Thymoma Oxnard ISL John's Rcgiopa! Medical Center) ·Spindle oell thymoma (2); Thymoma (I) San Diego fNava! Medical Center) • Thymoma, type AB (I); Thymoma (I) Santa l!arbam ICottaae Hospital) - Thymoma San Francisco CSan francjS!CQ Gcneralllosoitall • Thymoma Santa Rosa !Santa Rosa Memorial !!ospj1all • Thymoma (3) Ycnturai\JNU.ABl -Thymoma Woodland Hills CKaiscr Pepnanentc Medjcal Center) • Thymoma, type AB (2) At1w!sas IUnivcrsjLy or Ma!nsas M9diea! Center) • Thymoma Colomdo. llvC!l!J'CC!l - Thymoma Florida lJafkwn Memorial Hospital) .. Thymoma florida, Tall;, - Thymoma florida Obe Pa!holoey <lrouo) - Spindle cell thymoma (I); "lbymoma (3) florida CW"rnter Haven Hospital) • Thymoma Jl!inois fNaYJ! Hospital Gn:at Lakes) • Thymoma Illinois, Oak Brook - Thymoma Illinois <Loyola Univcrsily Medical Center) · Thymoma Jndjana !Ball Memoria) tlosojtal) - Thymoma !ndia!!a fK9bmo Pl!!ho!oci<t Health Sy$m) - Spindle cell thymoma Kentucky IUnjyersity orLouisvmc Ho:mital) - Type ABl thymoma Maty!and INatjona) Naval Modica! Ccoterl - Thymoma Mw:vJand (No!1hWCSie!Jll-lpsoita! Center) - Thymoma Marvland !University or Maryland) • Thymoma, type A M.......,!!Sdl;& fNew llnoland Medical Center) - Thymoma

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Micllip;an !'Oakwood Hospital! - Thymoma Minnesota <Fairview Rjd!!S$ Hosoi!all - Thymoma NcbraskaCCreigi!!On Unjymirv School ofMe<ljcipel - Thymoma New 'Yor!c; <Long Island Jewjsh Medical Ccntql - Thymoma, mixed lypc, AB New York <Nassau Unjycrsity Medical Centerl - Thymoma New Yorlc <New York Stony Brook OnjyersjiV Ho:mital Residents! - Thymoma, spindle New Yor!c !SUNX Downs!Jlle ResjdeniSl - Thymomo, sclerosing New Yorlc (Westchester Medical Center) - Thymoma Nor!h CaroHna <Mountain Area l'athologyl - Thymoma (S) Peonsv!vania CConcmaucb Memorial Medicpl Ccplql - Spindle eeU thymoma Pennsylvania CMt. Ni!!My Mc!lical Center! - Thymoma PC!!!!S)!Ivania rPC!!!!S)!Iyanja llosoj!al Residw!S) - Thymoma Tms Lubbock · Thymoma Iem !Propa!b "-swci81esl - Thymoma (2) Tcxa.• (Wilford Hall Medjcal Center) - ll1ymoma Tcxa• <Scotl & White Memorial H05Dilall - Thymoma West Viminia <Greenbrier Valley Medical Cenl\.7) - Thymoma, lymphocytic pred.ominance West Virginia CWel2.cl Coypty Hospita!l - Thymoma, mixed type Wjl!C!)nsin (Bemn Hca!l!hl - Thymoma Wisconsin <Mcriter Hospjta!l · Thymoma W15C00Sin <Pathology A:s!QCillleSl - Thymoma (2) AUSIJ'alia CNO!I!t Old J'aJbology Group) - Thymoma spindle eeU mixed AuSI!Jilia !Royal Hoban llo<oitall - Thymoma (WIIO type AB) Australia <Royal Prince Alfn:d Hospital! - Encapsulated thymoma (AB) AUSIJ'alia (Sullivan Njcoloidcs Pathology) " 'lllymoma--AB Gennany (UKE. Kgmjnsljtut fur Pathologic) - 111ymoma, lypc A Ireland <Kerrv General Ho:millll) - Type AB (mixed) thymoma Jgmaica fThe UnjveWIV of the West Indies) - Thymoma, type A l!!!!l!!l <Kyoto Univmjty tiO$J!itaJl - Thymoma, type AB l!I!!!!J! <Nagoya University School ofMeclicine) • Mixed lhymoma New Zealand !O!;yto Dj!!l!!!ostic Labl - Thymoma, type AB f'uertn Rj00 !Univcrsjly of Puer1o Rico School of Me<licinel - Thymoma Saudj Arabia CKins FahBd National Guard i'lospj!aD - Thymoma, type AJ) Oa!Q[ !Hamad Medjcu! Comorntlon) - Thymoma

C••• 4 - Oiaenosis: Thymoma, mediastinum

T-Y2300, M-85800

Case 4 - References: Minniti S, Valentini M, Pinali L, ct aL Thymic Mnsscs of the Middle Mcdia.~inum. Report of2 Coscs nod Review of the Litem!un:.

JThorac lmuging 2004; 19(3):192-195. Chalabreysse L, lltinnc-Ma.~roionni B. Adclcinc 1', Cl al. 111ymic Careinoma. A Clioioopathological and lmmunohisro!ogica! S!udy

of 19 Cases. HLrtopotlroi 2004; 44(4):367-374. Sundaram C, Rajagopul P, Rakshak AD, eta!. Clinicopathological Study of111ymomas-Correlation of Histologic Subtype 10

Myasthenia Gnlvis and Prognosis. JndkutJ Potlwl M'u:robio/2003; 46(3):378-381. Sperling 8 , Muschall J, Kennedy R, ct al Thymoma. A Review of !he Clinical :md Palho!ogical Findinl!)l in 65 Cases. Can J Swg

2003; 46(1):37-42. Sasaki H, Ide N, Fulcai I, e1 al. Gene Expression Analysis of Human Thymoma. Com!IIICS With Tumor Stage:. Im J Can011r 2002;

I 01(4):342-347.

Case No. 5, Accession No. 30051

Alameda, (Alameda Coynlv Medical Center} • Adrenal conical adenoma Alameda <Garfield Mc!lical Center) - lldrellal conical adenoma Baldwin Parts (Kaiser Pcrmanrotel - Adreooconlcal adenoma (3) fonl!!na (Kaiser Permnnenrc Hosoital) - Adrenal cortical adenoma Glendale - Adrenal conical adenoma Hayward/fremont !St. Rll!!!: HOl!!ljtall - Adrennconical adenoma fq ine CUnivcrsitv ofCaljfomia Irvine> - Adrenal adenoma

Marcb 2006

CJTR, Marcll2006 • MiniXts" (Subscrlp!ion A)

!.oma Linda ILoma Linda University Mc4jg! <&ntu Patbo!ogy Rcsjdentsl - Adrenal cortiC$1 adenoma Lgpa Rwb ILaJrewgod Rcflional Mc4ic:a! Cmtcrl - A<lmloconiC$1 adenoma (I 0) Mon!crcv Parle <Monterey Peninsula Patho!OAistsl - Adrenal corticnl adenoma MoynWp V jcw ffil Cwnjno P!l\hologyl - Adn:na! cortical adcnoDlll Ooogc (Orange Countv Mcdicnl Grouol - Adrenal cortical adenoma Oxnard CSt. John's ReGional Medical Ccntql - Adrenocortical ncOj'llnsm, probably adenoma ( I); Cortical adenoma (2) San Qicgo <Naval Mc!lica! Center! - Adn:na! adenoma (I); Adrctal cortical adcooma ( I) Santa Bad!ata CCgtpw !iospitaJl - Adrenal eorliC$1 neoplasm. favor bccign San francisco CSan Fmncjsco General Hospjta!l - Adrenal cortical adenoma Sa!!ta Rosa CSanta Ros Memorial Hosnita)l - Adrenal cortical adenoma (3) Vcotym aJNR.AB\ - Adl1:tllll cortical adenoma Woo<! land Hills CK&iser Pcrmancotc M<:djca! Center) • Adrenal cortical adcnomu (2) AdcanS!!S (University ofArtcan.<as Mcdic:aJ Copter\ - Adrenal cortical adenoma Co!gl)do Evmrecn - Adrenal cortical adenoma florida C1oc!sson Memorial HoSPital) - Adrenal oortical adcnoma florida. Tallab!'TT · Adrenal adenoma Florida CTbe Pa!hology Group> - Adrenal cortical adeooma (4); Adrenal adenoma (I) Florida CWinl£[ Haven Hospital) - Adrenal cortical adenoma !lljpgjs <Naval Ho.mUnl Great Lakes\ - Adrenal oortical adeno,ma ll!jnojs. Oak Brook - Adrtrull cortical adenomu Illinois (Lgyola Universjtv Medical Center) - Adrenal oortieal adenoma lndjana <Ba!J Memorial Hosoita!l • Adrenooortical adenoma lo4japa CKokamo Pa!bo!oaiS! Health System\ - Adrenal eorlical odcnoma Kentucky f!Jnjversitv gfLouisville HosoitAO - Nodular bypaplasia Mary! lind <National Naval Medical Ccntq l - Adrenal cortical adenoma Marv!and CNortbwCSitn! Hospital Center) • Adrenocortical adenoma Mf!!Yiand <University gf Marvlandl - Cortical adenoma M•wh'JSe!lS CNew rwg!aod Medical Centyl - Adrenocortical adenoma with cmcocytic change MjchiK!ID <Oal;wood HOS!!itall - Adn:rtooorlical adeooma M'IDJlCS9!a{fairvicw Rjdm Hospital\ - Adrenal cortical adeooma t+£hm'kl <Creighton Uojymity School ofMcdiciMl - Admlocorti<:al adenoma New Yotk (Lgng Island Jewish Medical Center\ - Adrenal cortical adenoma

· New York CNassau Unjvc;rsity Medical Ccntql - Adrenal cortical adenoma New Yor!cCNew York Stony Brook Univell!ltv Hospital Resident.'!) - Adrenal oortical pigmented adenoma New Yor!c CSVNY Downstate Residents> - Adrenal oortical adenoma New York CW!CS!Fhs:gq M¢ica! Center\ - Adrcoooortica! odcnoma Ngnb Carolina IMounWn M:a Pa!lu!!ogyl - Adrenal oortical adenoma (2); Adrenal cortical neoplasm (3) PenMylvania !Concmauab Memorial Mc<lical Center) - Adrenooorlica! adenoma Pennsylvania CMt. Nii!My Mc!l jcal Center) - Adrenocortical adenoma Pennsylvania CPennsy!voni~ HoS!Iital Resjd!:nts} - Incidental Rdi'CIIal cortical nodule Tem Lubboefs. - Cortical adenoma Texas CProoa!h AssQcja]W • Adrenal oortica! adenoma (I); Adrenocortical adenoma ( l) Tar (Wilfurd HaD Mc<ljcal Cenlerl - Adrcoal oortical adenoma Ism CSco!t & White Mgnorial Hospital! - Adrenal cortical adenoma West Virginia CGtecnbriq Valley Medical Ccntq) - Adrenal cortical adeooma WC1!1 Yi!l!inia CWetzcl County Hospital) • Cortical adenoma Wilconsin CBcllin Health! - Adreoal oortical adenoma Wisconsin fMeriter tlo.ll!itall - Adreno-oortical adenoma Wjscgosin IP!!!bology Associates) - Cortical adenoma (I); Adrenal cortical adenoma (I) Al!!!nl!ja CNortb Old Pa!boloav Groun\ - Adrenal cortical adenoma Al!l!IJ!ja CRow Hoban Hospital) - Adrenal cortical adenoma Au!traJia CRow Prince Alfred HospUal) - Adrenal cortical adenoma Australia !Sullivan N;00faides Pa!l!olggyl - Adrenal cortical adcnana Gqmany lUKE. Kennin!j!itut fur Pa!hologjc) - Adrenocortical adenoma lrc!und IKcqy Genera! Hospital! - Adrenocortical adenoma Jomaica Cll!c Univc:njty of the We.<t Indies\ - Adrenocortical adenoma ll!llll !Kyoto Uniymj!Y Hospital\ - Adrenocortical rumor (adenoma) Iapan CNagova Univmjty Sc!Jool ofMedicincJ - Adrenal eorlical adeooma New Zealand <Otaao Diwostic L8bl - Adrenal cortical hyperplasia Pucno Rico CUojyeaity of Puerto Rico Scllool of Medicine) • Adrenal cortical adenoma Saudi Ambia C!Gn• fahBd National Guard Jolosnitall - Adrenal cortical adcnoma !.)a)Ar !Hamad Me4ica! C0morationl - Adrenal cortical adenoma

9

Case 5- Diagnosis: Adrenal cortical adenoma, left adrenal

T-93000, M-83700

Case 5 - References: Walz MK. Extent of A~renalectomy for Adrenal Neoplasm. Cortical Sparing (Subtotal) Versus Total Adrenalectomy. Sw-g Clin

North Am 2004; 34(3):743-753. NIH State-of-the Science Statement on MW!agcmcnt of the Clinically Inapparent Adrenal Mass ("lncidentaloma"). NIH Consens

State Sci.Statements 2002; 19(2): 1-25. l'aulscn SD, Nghicm HV, Korobkin M, Caoili EM; ct al. Changing Role of Imaging-Guided Percutaneous Biopsy ofAdrenal

Masses. E\'3luation of SO Adrenal Biopsies. AJRAmJ Roentgeno/2004; 182(4):1033-1 037. McDonnell C and Zacharin M. Adrenal Cortical Tumours. 25 Years' Experience at the Royal Children'sHospital. Melbourne. J

Paedwtr Child Tflth 2003; 39(9):682-685. Stojadinovic A, Brennan MF, Hoos A. ct al. Adrenocortical Adcnoma.and Carcinoma. lii~topathological and Molecular

Comparative Analysis. Mod Patho/2003; 16(8) :742-751.

Case No. 6, Accession No. 30052

Alameda (Alameda County Medical CentCI') - Adrenal cortical carcinoma Alameda <Garfield Medical Center) • Adrenal oncoc)toma Baldwin l'atic (Kaiser Permanente) - Adrenocortical carcinoma (I); Adrenal cortical carcinoma (2) fonmna !Kaiset Perrttanente Hosoitall - Adrenal cortical carcinoma Glendale - Adrenal cortical carcinomn Hayward/Fremont fSL Rose Ho.snitall - Adrenocortical carcinoma lryine <University of California frvinel - Adrenal cortical carcinoma J.omn Linda !Lorna Lmda University Medical Center Palhology Residents) - Adrenal cortital carcinoma Long Beach (Lakewood Regional Medical Center! • Adrenocortical carcinoma (I 0) Monterey Park !Monterey Peninsy(a Pa\hologj~} - Adrenal cortical carcinoma Mnuntajn View rEI Camino Pathology) · Adrenal cortical carcinoma, oneocytic type Ornqgc !Onmgc County Medical Groun} • Adrenal cortical carcinoma

March 2006

Oxnard (SL Joftn's Regional Medical Center} - Adrenocortical carcinoma (I); Cortical adenocarcinoma(!); Adrenal cortical carcinoma (I)

San Diego <Na\'31 Medical Center) • Adrenal cortical carcinoma (2) Santa Barbara !Co!!ase Hospital) . Adrenal cortical carcinoma San Franci,;ro £San l'!!l!lcim Geneml HoSpital! - Adrenal cortical carcinoma SantA R<IS!l.CSanta Rosa Memorial Hospital) • Adrenal 9orti<1!! ~!noma (2); Adrenal neoplasm c!w adrcnoconical carcinoma ( 1) VenturallJNILABl • Adrenal cortical carcinoma Woodl!llld Hills <Kajser Permanente Medical Center} - Adrenal cortical carcinoma (2) Mansas !Univc:rsity of Arkansas Medical Center) • Adrenal cortical. carcinoma Colorado Evergreen • Adrenal conical carcinoma Florida (Jackson Memorial Hospjtal) - Adreoal cortical carcinoma Florida. Tallahassee · Adrenal cortical carcinoma Florida fThc Pathology Group> • Adrenal cortical carcinoma (3); Adrenocortical carcinoma (I ) Florida (Winter liaven Hospjtall - Adrenal cortical carcinoma Illinois <Naval Hospital Great Lakes) • Adrenocortical carcinoma Illinois. Oak Brook • Adrenal cortical carcinoma Illinois O..oyola University Medical Center> - Adrenal cortical carcinoma Indiana (Ball Memorial Hosoitall - Adrenocortical carcinoma , · Indiana CKokamo Pathologist Health $vsteml - Pheochromocytoma Kentucky <University of Loui-'Ville HoSpital) · Adrenal cortical carcinoma Maryland <National Naval Medical Center) · Adrenal cortiCal carcinoma Maryland l}!orthwestem Hosoital Center) • Adrenocortical carcinoma Maryland !University ofMarvlandl - Cortical aueinoma Massac;husens <New EngiWld Medical Center) · Adrenocortical carcinoma Michiw !Oakwood HosoitaD • Adrenocortical carcinom• Minnesota <Fairview Ridges l losnitall - Adrenal cortical carc:inoma Nebraska !Creighton University School of Medicine} • Adrenocortical carcinoma New York CLong Island Jewish Medical Center) - Adrenal cortical carcinoma New York !Nassau University Me4ica] Center) - Adrenal cortical carCinoma New York CNew Yorls; Stony Brook University Hospital Resident<) • Adrenal eortiClil carcinoma

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New Yorl\ !SUNY Oowmtate Residents) • Adrenal conical carcinoma New Yorl< <Wesu;bestq Msdical Center! • 1\d=ocortieal can:inoma Non!J Carolina IMoun!!Un Area Pathology\ • Adrerolcortical c~~n:inoma (5) Pellll!!ylvania IConemnunh Memorial Medjca! Center) - Adrenocortical carcinoma Pe!l!}SYIYW1ia (Mt. Nillnny Medical Center\ • Adrenocortical carcinoma Pcrmsylyaoja (Pennsylyaoia Hospital Residen!SJ - Adrenal cortical carcinoma T!:XJI$. L!Jbb(!clc • Conieal adeooc:azcinoma Tms <Pmpotb Asgvja!CS) • Adrenal cortical carcinoma (I); Adn:nocortical carcinoma (I) Icxas (Wilford Hall Mc!lical Center) • 1\d=al conieal carcinoma lew !S<O!I & White Memorial Hospital) • Adrenal cortical carcinoma West Virginia fGreenbrier Valley Medical Center> - 1\d=al cortical carcinoma WCI!t Vlminia <Wetzel County Hosnital) • Adrenal cortical carcinoma Wisconsin !BeWn Heafthl - Adrenal cortical carcinoma Wjsatnsin (Meriter liospjtall • Adrcnoconial carcinoma. oncocytic variant Wpconsin (Pathology Assocja!CS) - Cortical carcinoma(!); Adrenal conical carcinoma (I) Aus!ra!ia (North Old Pa!hology Group> • Adrenal cortical carcinoma Ayl<!l!!lia IRoval Hobart Hospital) - Adrenal cortical carcinoma Aus~ralia IRova) Prince Alfred Hospital) • Adrenal conical carcinoma Austm)ja <Sullivan Njcolnjdes Pathology) • Adrenal carcinorD)l ()qmW1y lUKE. Kqm!nstjtut. fur Patholooiel - Adrenocortical carcinoma. oncocytie leland <Kerrv General Hospjtall • Adrenocortieal carcinoma J•mnica. <The UniYf::aity of the wes. tndiesl - Pbaeoch.romocytoma li!!!I!J !Kyoto Unjymitv Hospital) - Adrenocortical carciooma li!!!I!J INa&ova Uniymjw Scbool ofMedicjnel • Adrenal cortical carcinoma New Zealand I'Ota.!!o Di•anostie Lab I • Adrenal cortical carcinoma l'uqto Rico <Uojvcrnjty ofPucrtg Rico Scbool ofMediejoel • Adrenul cortical carcinoma Saudi Arabia <King Fabad National Guard llospitall - Adrenal cortical carcinoma Oo!ar !Hamad Medical Cosporation) • Adrenal cortical carcinoma

C!se 6 - Diagl!osio: Adrenal cortical carcinoma. right

T-71000, M-83703

eaw 6 - References,: CoultaCL. Smith RE. Stowasser M, ct el. Expression of If Beta·Hydmxysteroid Dehydrogenase Type 2 (II BetaJJS0-2) in the

Developing Human Adrenal Gland and Human Adrenal Conical Carcinoma and Adenoma. Mol <All £ndocrinal 1999; JS4(1· 2):71-71.

Fctscb PA. Powers CN, blcowski MF, et el. Anti-Aipha-tnhibin. Marker of Choice For the Coosistent Distinction Bctwoc:n Adrenocortical Carcinoma and Renal Cell Carcinoma in Fine-Nce<ffe Aspiration. Cancer 199'.1; 87(3):168-172.

Sasano H, Sbizawa S uod Nngurn H. Adrenooortienl Cytopathology. AmJ Clln Pothol 19'95; 104(2):161-166. Ahlman H, Jansson S. Wangberg B, et al. Adrenocortieal Carcinomo-DingnOSiie and Therapeutical Implications. Eur J Surg 1993;

IS9(3):149-IS8. Umon J, Pal Cin P, Kakali $, et al. Cytoaenetie Findings in a Primary Adrcnoconical Camnoma. Con«r Gelid Cytogenet 1987;

26(2):271-271.

Case No. 7, Accession No. 30007

Alameda IAiamgla Counlx Medical Cenfq\ - Angiomyolipoma Alameda (Garfield Mc!lical Center) • Angiomyolipoma !la!dwjn Park IKai= PermancnJ.el - Angiomyulipoma (3) fontana <Kaiser Permaoentc Hospitall - Angiomyolipoma Glendale - Angiomyolipoma Haywwdlfn:mont ISL Rpse Hospital) • Angiomyolipoma Iaine {Univgsjty of California Irvine) - Angiomyolipoma l.oma Linda <Lorna !.in4a University Mc!ljeal Center Pathology RC§jde!!tsl - Angiomyol ipoma Lona Ocad! ~Lakewood Reaional Medical Center\ - Angiomyolipoma (10) Monterey Park <Mooters:v Pminsuta Patholopj:nsl ~ A.ogiomyolipoma Mountain View lEI Gamjno Pathology) • Angiomyofipoma Omnoe <Orange Countv Medjenl Group) - Aogiomyolipoma Oxnard IS!. Jobn's Rcciopal Medieal Center! - Angiomyolipoma (3)

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March2006

II

San Diego !Naya! Medical Center) - 1\ngiomyolipoma (2) Santa Barbara <Cotl!!ge Hospital) - 1\ngiomyolipoma San Franciss;o !San Frnncisco Genem! Uospitall - Angiomyolipoma Santa Rosa !Santa Rosa Memorial Hosojtall • Angiornyolipomu (3) Venl!!ra <UNilA!l\ - Angiomyolipomn Woo<llan<f lfitls ll<aiscr Pennanen!Q Mc;dical Centerl • Aogiornyolipoma (2) 1\rlcaosas CUnjymjry of 1\rbnsas Medjca! Center) - Angiomyolipoma. kidney Co!otadc!. Eyqgn:m - 1\ngiomyolipoma florida Oa.:kson Memorial Hospilo!l • 1\ngiomyolipoma florida. Tallahassee • 1\ngiomyotipoma florida IThe Pathology Qroun) • Angiomyolipoma {5) Florida IWtnter llaycn Hospital) - 1\ngiomyolipoma !I! innis !Naval Hosoiln! Great Lakes) • Angiomyolipoma !l!ioojs. Oak Brook - 1\ngiomyolipoma !l!inois <Lovo!a Unjycrsitv Medical Center) - 1\ngiomyolipoma Indiana (!lal! Memqrin! Hospilnll - 1\ngiomyolipoma Indiana !Kokamo Patho!ogi<t Health System) • Angiomyotipoma Kentucky CUniyq:<ity of Louisvmc Uospitall - Al>giomyotipoma Maryland CNnlional Naval MediClll Center! - 1\ngiomyoUpoma Mary!l!l!d (Northwestern Hospital Center> • Angiomyolipoma Maryland CUnjymitv ofM!!!Ylandl - Al>giomylipoma Massacbusell$ CNew Englan<f Medical Center! • Al>giomyolipoma Micl!i•an !Oakwooc! H!l§!)itaJl • 1\najomyolipoma Minnesota (Fairyjsw Ridges HosojJall • Al>giomyolipoma Nebraska CCreiahton University School nfMcdic,ine) - Angiomyolipoma New York <Long Island Jewish MedjC!!I Center) • 1\ngiomyolipoma New York (Na ... u University MediC!II CCll!erl • Al>giomyollpoma New Vorl< (New Yorlc. Stony Brook Upjvmity HospjJal Resjdcntsl - Al>gjomyolipoma New Vorl< <SUNy DownstBie RcsidCD!Sl • llngiomyolipoma New Yorlc. (W ... rl!cs!er Medical Ccntql - Al>giomyolipoma North carolina <Mountain Area Pll!holoayl - Angiomyolipoma (5) PcnnsviVl!l!ia (Conemaugh Memorial Mc;djcal Center! • 1\ngiomyo!ipoma Pennsylvania <Mt Njuany Medical CeD(Or) - Renal angiomyolipoma PennsyJyania CPenn3ylvanja lofo.c:pital RcsidenlSl - AngiomyoHporoa TCO<aS. Lubbock • llngiomyolipoma Teas IProD8!h MMfi!IQSl - 1\ngiomyolipoma (2) I t!!$ (Wilfon! tli!ll Medical Cmterl - 1\ngiomyo!ipoma TClaiS CScou &. Wbitc Memorial Hospjg!l) • Al>giomyo!ipoma West Virginia <Greenbrier Valley Medical Center) - Angiomyolipoma West Virginia (Wl:JUI County Hosnitall • 1\Qgiomyolipoma Wisconsin !llel!ip Health) - Al>giomyolipoma Wisconsin IMcrjtq Hospital) • Al>giomyolipoma Wisconsin <Pa!hology Associates) • 1\ngiomyolipoma (2) Australia (No!!h Old PaJho!ogy Gmypl • 1\ngiomyolipoma Austi81ia CRoyalllnbart Hospital) • 1\ngiomyolipoma Aumalia <Royal Prince Alfu:d HOMjJal) • 1\ngiomyolipo.na Australia CSulliyan Njeo!nides Pathology) - Al>giomyolipoone Germany CJJKf. Kcrminstitut fur Pn!holqgicl - Al>glomyollpoma Ireland CKmy General Hospital) • 1\naiomyo!ipoma Jomaic::a CTbe Unjycrsity of the West fndjc:sl - Angiomyolipoma Jaoan (J(yoto \Jpiymity t!OS!lita!l - 1\ngiomyolipoma Jap;m IN!!!Ilm! Unjyersity School of M!ldjcjnel • 1\ngjomyolipoma New Zealand !Otnsg Di32J10stjc Lab! • Al>giomyolipoma Puerto Rieo !Uojycc;jty of Puerto Rjeo Scllool ofMedicjnel • Angiomyolipomn s,,udi 1\mhia IKjns FBhad Nationn! Gu!Jillllosnitall • 1\nglomyolipoma O!!tar <Hamad Medical Co!])()ratjool • Al>giomyolipoma

C..... 7 - Oia!!J!Mis:

ll

Angiomyolipoma, right kidney T-71000, M-88600

CITR, Mmh 2006 "MinUOC$" (Subscripeioo A)

Case 7 - References: Kim JK. Park SY, Shon Hi, et al. Angiomyoliporoawith Minimal Fat. Differentiation from Renal Cell Carcinoma by Biphasic

l:lelical CT. Radio/2004; 230(3):677-634. Gronchi A.. Dlmcnt J, Colecchia M, et al. Atypical Pleomo'l'hic Epithelioid Angiomyolipnma Localized to the Pelvis. A Case

Report and Review of the Literanue. Hlstopo!ho/2004; 44(3):292-295. Krishnan B. l.echago J, Ayala G, et al. lnll'80pcntive Consullalion for Renal Lesions. Implications and Diagnostic Pitfalls in 324

Cases. AnrJC/in PaJho/2003; 120(4):528-535. Leclerc JC, MIIJ'Chal P, Stine,; J, et at. EpiU1elioid Renal Angiomyolipoma. (Benign or Malignant tumor?) J Radio/2003; 84(7-8 Pt

1):851-854. (French) Nilcaido T, Nakano M, Kalo M, et aL Chanll:tc:rizabon of SmooU! Muscle Componcnu in Renal Angiornyolipomas. JUsto logical and

Immunohistochemical Comparison with Renal Capsular l.eiomyomas. Palhollnt 2004; 54(1):1-9.

Case No. 8, Accessioo No. 30055

Alameda CAlomcda County Medical Centerl - Adrenal myelolipoma Alarned!l COnrfie!d Medical Center! - Myelolipoma Baldwin Park IKaiscr Pcnnancntcl - Adrenal myelolipoma (3) Fontana <K•isr Pennane:ntc Hospital) .. Myelolipoma Glendale - Myolipoma Hayward/Fremont 1St. Rose Hospital! - Myelolipoma lryine (lJoivc(Sjly of Califomja~ • Myelolipoma !.oma Linda IL9ma Linda Unjyersity Medjgll Center Pathology Residenl$1 - Myelolipoma Long !>ter!t O.tkcwooc! Regjonal MC!Iicn! Center! - Myelolipoma (I 0) Montaey Pad< (Mootcn:y Peninsula Pa!hologjsJs) • Mye.lolipoma Mountain View l!ll Camino Pathology) - Myelolipoma. adrenal origin Omnge IOrangc County Medical Group) • Myelolipoma OXI!llrd CSL John's Regional Medical Cen!crl -Myelolipoma (3) San Diogo !Naya! Medical Center! • Myelolipoma (I); Adrenal gland with myelolipoma {I) Santa 8aJbara ICqttase Hospjla!) - Myelo6poma San F!8!!ci;soo CSan F!l!!!cisoo General UospjtaD - Myelolipoma Santa Rosa !San!a Rosa Memorial Hospilllll - Myelolipoma (2); Adrenal myelolipoma ( I) Ventura OJN!!.AQJ - llxtrnmcdullaty hemlllopoiesis

Marcb2006

Wooc!land Hills CKaiser l'ermanente Medical Cen!erl - Myelolipoma (adrenal) (I); Adrenal gland myelolipoma (I) Albna< OJqjversity or Arlcan.'!!!S Medical Center! - Myelolipoma, kidJ>ey Colorado. Eyqareen - Myelolipoma f lorida !Jru:k.'iQp Me!llorial!io:mitall - Adrenal myelolipoma florida. Ia!lahD!!SCC - Myelolipoma ~lorida CThe Pll!bo!ogy Grouol - Myelolipoma (S) florida CW"antq Haven Homj!All - Adrenal mye!oliponu~ Dljqois CNaya! Hospi!l!] Gre!!l Lakes! - Myelolipoma !l!inois. 00 llrook - Myelolipoma, adrenal gland Illinois flovola Upiversity Medical Center) - Myelolipoma Indiana !Ball Mqnoria! Hospj!all - Adrenal myelolipoma Indiana !Kc*II!!O PatholoaiS Health System! - Extrnmedu!laty hematopoiesis Kentucky CUniversity oflouj»ille Hospilall - Myelolipoma Mwyland <National Naval Medical Center! - Renal cell carcinoma MartJand <Nonbwcstem liospj!al Cen!er) - Myelolipoma Ml!yland CUnjversity of Maryland! - Myelolipoma M h!JSd!3/New E!!gJand Medical Ceniql - Adrenal myeloliponul Micbi!!3!) COakwpod Hospital) - Adrenal myelolipoma Minnesota (fnjrvjew Ridocs Hospital) - Myelolipoma Nebraska CCn:igh19n UnivC!l!jty School ofMcdicjnel - Myelolipoma New Yort Cl.onc Island Jewish Medical Cen!crl - Myelolipoma New Yort <Nassau Uoiversi!y Medical Center! • Myelolipoma New Yort <New Yotlc Stony Brook UniymilY Hospital Rs.<ideo!S) - Myelolipoma N<:w Yods CS!!NY Downstate Resident~! • Myelolipoma New York CWestc!JesterMe<llca! Center! - Adrenal myclolipon>a North Carolina (Mountain Arq l'll!hologyl - Myelolipoma (S) Pmmy!yany CConcmaum Memorial Me!lia!l Center! - Adrenal myelolipoma Pennsylvania CML Nittanv Me!lica! Center) - Retroperitoncal myelolipoma Pennsylvania (J>ennsv!vania Ho:mital Resjdcn!sl - Myelolipoma

(.Tl'R, March 2006 "Minulc$" (Subscription A) 13

TCJ!&'. Lobboe!s - Myelolipoma Im• lPmnath Asso!;j!!leS) - Adrenal myelolipoma (2) TCJ<as !Willard Hall Medical Center) - Myelolipoma TI)XllS !Scott & Wbjte Memorial HOSPi\!ill • Myelolipoma West Virsinia (Qrpeobrier Val lev Medjcnl Center! • Myelolipoma West Virginia CWet:!.cl County Hosn.ilA!l - Myelolipoma of adre!lal Wisconsin <Bellin Health) - Myelolipoma Wi'i!X!!!.;n {Mqj!q Hospjtall - Myelolipoma Wisconsin <Pat!!ok>gy Associates! - Myelolipoma (2) Australia <North Old Pathology Grouol • Myelolipoma Augra!ia IRoyul t!obnrt tlospitall • Myelolipoma Australia IRovn! l'rjncc Alfred tlosnlfA!l - Myelolipoma Australia (Sulliyan Nicolaides Pu!hglosxl • Myelolipoma Gqmany (UK£. Kqmjnstitut fur Pa!hologje) • Myelolipoma Ireland fKerry \.egcnl Hospifllll - Myelolipoma lamaic:a CThe Unlymity of tbe West Indies) - Myelolipoma, adlenal gland Jnnan (J(yoto Unimsity HospitaO • Myelolipoma Jopan <Nasoya Uoiyersitv School of Medicine) - Myc!o!iporoa New Zeal8!ld <OlAno Dio•nOS!ic L.1bl • Adrenal mycloliporua Puerto Rico OJnjl'l.'f!jjty of Puerto Rico School ofMedicjoe) • Myc!olipoma Saudi At8bia CKinn fabad National Guard Hospital) • Myelolipoma Oa!sr <Hama!l MC!Iieal ComoJa!jonl • M)-.:lolipoma

Case 8 - Diagnosis: Myelolipoma, adrenal

T-Y4600, M-88700

Case 8 Refcn:accs: Wqocrova H. l.a2urova I, BobeT J, e1 al. AchaJal Myelolipoma. 6 cases and a Review ofthcl.itcratun:. Neop/IJrmD 2004;

SJ(4):300.3~. Ma!hews K, Sasson A and Cohen S. Putbo!ogic Quiz Case. A Woman with Abdominal fullness. Adrenal Myelolipoma. Arr:h

Pathoi/Ab Med 2004; 128(6):703· 704. Nakajo M, Oooham S, Shinmum K. et al. Emboli71llion for Spontaneous Retroperitoneal HcmonM&c from Adrenal Myelolipoma.

Radial Med2003; 2!(S):214-219. OsbornM, Smith M, Scnbanjo T, e1 al. Adrenal Mye!olipom&-Ciinica~ RadiologieaJ and Cytological Findings. A Case Report.

Cytopatlrol2002:, 13(4):242-246. Reza·Afbamm AA. Gomez-Percz FJ, L<>~ IC. d al. Myelolipoma A New Adn:nal Finding in Carney's Complex? ENJocr Patlrol

1999; 10(3):2Sl-2S7.

CueNo. 9, Accession No. 30091

Alameda <A!llmeda County Medical Center) - Gasuointestinal stromal tumor Alameda !Garfield Medical Center) - Gastrointestinal stromal tumor Baldwin Parle {Kajsq Pennanente) • Gastrointestinal stromnl tumor (3) Fontana !Kaiser Permnnenlc Hospjtal) -Gastrointestinal suoota! tumor Glendale - Malignant cpi!hetioid g.astrointe.1inal stromal tumor Hayward!Fn;mont 1St Rose Hospi!Ail - GastrointJ:stinal stromal tumor, probably malignant !ryjnc <Univmitv ofC&Iiforoja Irvine) - GastrointJ:stinal stromal tumor, epithelioid variant

Marth2006

L<>ma I Jrn!a a.oma Linda UnlyersjiV Modieal Ccn!q Plltho!ogy Residents) - Gastrointestinal stromal tumor (GIST) Long S.:..:h ll.akewoo<l Regional MC!Ijc:nl Center) - GIST. malignant ( I G) Monterey l'arl< IMonJerev Penin<ula Pathologists! • llpi!hclioid gastrointOS11nnl stromal tumor, favor malignllllt Mountain y;ew CEI Cwnino P!l!ho!oeyl - Epithelioid Gl stromal tumor Orange COmnge Couptv Medieal Grouol - Gl stromal tumor Oxnart! 1St. John's Regional Medjeal Center> - Gastrointestinal stromal tumor (3) San Dfego (Naval Mcdieal Ccntcrl - Epi!helioid gJStrointcstinal stromal tumor (1); Gastrointestinal stronta! tumor (I) Santa Baibam CCol!llae Hospital! - Gastrointeronal stromal rumor, higll risk San francisco <San Frnnei:;co Genem! Uospitall - Epithelioid gastrointOS1ina! .stromal tumor San!Jl Rosa !Santa Rosa Memorial Hru;lli!!D - GasltoinlCStinul stroota! tumor (3) Ventura(IJN!LABl - Gustrointestinnl stronta! !Umor Woodland nillsiKaiser Pennaoente Medical Center) • Gastrointestinal stromaltiUIJor (I); Epithelioid gastrointestinal stromal tumor

t4

(I) Arkanl!3S Noivcrsitv of ArkMSl!S Modjcn! Center) • Gascroinu:stinal stromal tumor, small bowel Colorado. Eycrgrccn · GIISirointestinnJ stromal tumor florida fJach!l!! Memorial Hospi!all • Gastrointestinal stromaiiWnor (GIST) Florida, Tal!ahpscc • Gasuointc:stinal stromal tumor, high maliGJl>llt potential Florida Obe Pathology Group) • Epithelioid gastrointestinnlstrom.altumor (2); Ga.strointcstinnl stromal tumor (3) florida CWin!er Haven 1-!gspjta!l • GllSlrolntestinal scromnltumor ll!inojs !Naval HQSDjta! Great Lakes) • Epithelioid gastrointestinnl stromal tumor Illinois. 00 Prook - Gastrointrstina.l stromal tumor lllinois (Loyola Univtnjty Medical Center! - Gasuointestinal Stromal tumor, intermediate grade lpdjBI!a @all Memorial Hospital) - Gastrointcstinal •tromal tumor Indiana IKokamo PnthologjS! Health SySJeml • Gastrointestinal stromal tumor Kentucky CUnjvqsity of!.oyjsyille Ho:;pjtall • Low-grade malil!llanl gastrOintestinal stromal tumor MatyiBI!d <National Naval Medical Center> - Gastrointestinal Stromal tumor (epithelioid) M8!yland fNorthwcstcm Jo!ospital Center) • Gangliocytic parnganglioma M8!yland CUnjV!.'fSity ofMw:ylaodl • Epithelioid &UStrointcstinal stromal tumor M!S!I!fhusc!ls !New llnslnnd Medig! Center) • Gastrointestinal stromal tumor Mjclligan I'Oa!g!-ood Hospi!a!l - Gastrointestinal stromaltumo< Minncwta !fairview Rjdges Hospilllll • Gastrointestinal stromal tumor Ncbra.<d<a CCrelgbton Unjycrsjty School of Medicine> - GllSlrointcStlnal stromal tumor, maliJ!IlBI!l New Yorl< CLono Island Jewish Medical Ccntql - Epithelioid gastrointestinal stromal tumor New Yodc <Nmm• Ugivcrsity Modica! Cmterl - Oasrrointcs!inal stromal tumor New Yodc !New York Stony Brook Unjymity Ho:;pita! Residents! - Epithelioid gastroi.nltSiinal stromallllmor New York <SVNY Dowos!l!tc ResidenJsl - Epithelioid gastrointestinal stromal tumor New Yor!c <Wco.1cbesrq Medical Centq l • Gastroin""'1inal strOmal tumor, borderline malignancy North Carolina. (Mountain Area Pntholocv> • Gastroinl$inal stromal tumor ( I); Epithelioid gostrointcslinal stromalluroor (4) Pennsylvania !Conemauoh Memorial M<dica! Cquql - GllSlrointestinal stromal blmOr PsnnsyiYBilia (Mt Nittany Medical Ccnlc.-1 - Mali8J1BI!I gastrointestinal stromal tumor, small bowel PcnnsylvanjalPguJ$ylvani• HQSDital Residents) - Gastrointeslinal stromal tumor Texas. Lubbock • Malil!llant gastrointestinal stromal tumor Trvs lPropath t.ssnciatq> - Gasttointcstinal stromal tumor (2) Tms fWjtford Hall Medical Center) • Gastrointestinal stromal tumor

· J'cxa.• <Scou & Wbite Memorial Ho"Jlj!Ail - Ga..uolnteslinnl stromal tumor West Vugjnia <Greenbrier Valley Me!lica! Center\ • Small bowel gastrointestinal stromal tumor West Virgjnj• {Wetl!;l Cgsmty Hospj!al\ - Ma!i8118!lt gastrointestinal stromal twnor WISCOnSjn !Bellin Hca!thl • Epithelioid Gl stromal tumor Wisconsin (Meritcr Hospjtal\ - Gastrointestinal stromal tumor, maligJlant Wisconsin C!'athology A.'!SQCiatesl - Oastroinlestinal stromal tumor (2) Australia CNor1h Old Pal!Jology Group) • Gastrointestinal stromal tumor Au.mJja fRova! Hobllt! HospitaD • Gtlslrointcstinal Slro!Daltwnor (OISl) Al!.'lt!alia !Royal Prince Al!jpd HospitaD - Oastrointestinal stromal blmOr, epithelioid AI!S!!!l!ja !Sumyan Njcolaldes Plllhotosyl • Gastrointestinal stromal tumor GermanY lllKE, Kcnnin.'l!jtut fur Patbolo&icl • Gastrointestinal stromal tumor, epithelioid Ireland fKeay General Ho:;pj!l!!l • Gastrointeslinal stromal tumor Jwica Obe University gflhc West Indies) - Epithelioid gastroinl$inal Slromaltumor l!lf!M (Kwto University !lll@i!l!!l • GastroiniCSiinal stromal tumor lapuo fNagova University Scbool ofMg!jeinel • Epithelioid gaslrOintcstinal stromaltumot" New Zealand (O!ago Diagnostic Lab) • Epithelioid gastrointestinal stromal tumor, intermediate grade !'llc@ Rico O!niv=ity ofl'uato Rico Scl!ool ofMg!icjoel - Gastrointestinal Slromal tumor Saudi Arabit !Kjng Fah!!!l Na!jooal Gu3!'d HospjtaO • Epithelioid gastrointestinal stromal tumor Ollw !Hamad Medical Comoralionl - Gastrointestinal stromal tumor, borderline

Case 9 - Dj!posis; Gastrointestinal stromal tumor (G!S'I), smaU bowel

T~OOO, M-88903

Qn: 9 - References: Wang L, Vlr8JIS Hand Frerteb SW. Cellular Origin of Gastrointestinal Sll'Omal TIJmors. 1\ Study of27 Cases. Arch PathcliAb

Med2000; 124(10):1471-t47S. Hirota S. lsozaki K, Moriyama Y, ct al. Galn-<>f·Function Mu!alions ofC-Kitln Human Gastrointestinal Stromul Tumors. Scittu:o

1998; 279(S3SO):S77-S80.

C1TR, Matd12006 "Minutes" (Subscription A) IS

Heinrich MC, Rubin BP. Longley 8J, eta!. Biology and GencUc Asp<.-cts of0a<troinm1inal Stromal Tumors. Kll Aclivatlon and CyiOgenctic Alterations. Hum Pmho/2002; 33(5):484-495.

l'letchcr COM. Bennan JJ, Corless C, et a!. Diagnosis of Oasuointestinal Stromal Tumors. A Consensus Approach. Hum PaJltol 2002; 33(S):4S~77.

Oladell PP and Gunnan-Hartman. A Single lnstilution Review oftheN81iooal lnstil\<teofHeaJth Reeommendation for Prognostiealion ofGaslrointestinal Stromal Tumors. Hum Pmlwl2003; 34(S):SI2-S I3.

Case No. I 0, Accession No. 30092 March 2006

Alamcdn !Alameda County Medical Center) - Hemangiopericytoma Alameda IGadjcld Mcs!ical Center) - Solitaty fibrous tumor, hcmnngiopericytoma type Baldwjn l'llrls IKaisr Pcnnancnlcl - Soliiaty tibrous tumor, hcrnangiopcricytoma ( I); Soliiaty fibrous tumor (2) Fontana CKnlser Pcnnancnte Hospital) - Hcm!Ulgiopericyloma Glendale - Solilary fibrous tumor J-lal'Will'lllfMont !SL Rose Hospill!ll - SoliJaty fibrous tumor [ryine CUniyersiw of'Cnlifomia Irvine) - Solitary fibrous tumor Loma Linc!a !Lorna Linda University Medical Center PalholoeY RcsjdcnL•l - Fibroma of tendon sheath Lonelleacl! O.okewooc! Regional Medical Center) • Soli~a~y fib;rous tumor (8); Hcmangioperieytoma (2) MontC!eV Pwt rMonJer!:Y Peninsula Pathologists) - SoliJaty fibrous tumor Mountain Vjew !EI Camino P81hology) • HemaogiopericytOma Orange !Otanoc Countx Mcc!ica! Group! - Hemangiocpilhelioma 0xnan1 ISL John's Regional Medical Center! -Kaposi (I); Synovial tumor wilh focal atypia(necrosis) (I); Hemangioendothelioma

vs. Koposi (I ) San Diego (Naval Mcclica! Centerl - Hemangioperieytoma (I); Epithelioid hemangioendothelioma (I); Solitary fibrous tumor (I) Santa Badwa !Cot!AAe Hoopill!ll - SoliJaty fibrous tumor San Fmncjscg <Sao f11111cisco General Hospjtall - tlemangiopericytoma Santa Rosa ISMta RQ1!8 Memorial Hospilllll • Vascular tumor of unknown malignant potential (I); Vascular neoplasm of uncertain maliGI'ant potential ( I ); HemangioperieyiOma(l)

Ycnturo CUNI!.Ail) • Epithelioid hemangioendothelioma Woodlnnd Hills !Kqjsq Peonanente Medical Center! • Hemnnwopcricytoma (2) Ad<ansas !l!g!yc(l! jty of Arl<ansas Medico! Center) - Hemangiopericytomll, posterior knee Colorn!lo. EvCD>reen - Solitary fibrous tumor Florida OftCksgn Memnrj!l) 11osnitaJl .. Hcmangjopericytoma Florida. Tal!abassct - Hemangioma f1ori4a Qlle !'lithology Group) - Hcmangioperic)'lOma ($) Florida (Wintq Hayen !1ospilllll - Kaposi's hemangioendothelioma Illinois !Naval HaQ~j!al Gn:at Lakes) - Cellular solitary fibrous tume>r lllinoi$, QAk B!l!Ok - Solilal)l fibrous rumor Illinois C!.oxola llojyersjty Medical Center) • SoliJaty fibrous tumor Indiana <Ball Memorial Hospjtall • Hemangiopericytoma Indiana CKoU!!!o P81hotogisl Health System) • Kaposi's san:omo Kentuclcy !Uniyersity of Louisville Hospi!all - Hemangiopericytoma Marvland <NotionAl Nayal Medical Center) • Hcmangiopcricyloma Maryland CNorlhWl:S!qn Hospjtal Center) - Pleomorphic hyalini7.cd angiectatic rumor Marvland a!piycrsjty of M!l!}'land) - Hernangiopericytoma M!lS$!!cby;;cus !New England Medical Center) - Hemangiopericytoma Michi!!l!!! (Oakwood Hospital) - Sotiiaty fibrous uunor Minne.wa !fairview Ridges Ho>pill!ll - Bernnogiopcricytomo Nebmsk'o !CrejQhlon University School of Medicine) - Hemnngiopericytoma New Yor!c: (Lon• lslond lcwjsh Mcc!ieal Center) - Solilaty fibrous tumor New york <NnsS"" University Medical Ceo1erl - SoH1ary fibrous cumor New York <New Yorl\ S(9ny Brook University Hospital Rcsidenl§l • Hcmru>giopericytOma New York <SUNY Qowos•arr Resident<Q · SoHtary fibrous tumor vs. Kaposi sarcoma New Yor!c !Wcstcbcstcr Medical Center} - Spindle eel! hemangioma Nonh Carolina (Mountain Area P81hology) • SoliJaty fibrous tumor (4); HemangioperiCytOma (I) PennsylvagjaiConqnau!!h Memoria] M¢ieal Center) - Soli13ry fibrous tumorlhcmangioperiCytOma l'9lnsylvagia CML Nj!!l!ny Medical Center) · So6Jaty fibrous lllmor,lcft knee Pcnnsy!Y8!1ia CPcnnsylyanja Hospill!l Resideool - Epithelioid heroangioa>dothetioma Tens l.ubboc!s - C'-eell sarcoma TOM$ CPmpa!h t\mciattsl • Hcmangiopericytoma (I); Benign hemangioperieyiOma (I) Texas (Wilford Hoi! M!!dica! Centerl - Solitaty fibroU$ tumor

16 CTTR, Mareh 2006 "Minutes' (Subscription A)

Tgu <Scott & White Mgnorjal Hospital) - Solitary fibrous tumor WCS virginia CGrccnbrjer Valley Medical <&ntql - Hemangjopericytoma vs. synovial san:oma West Vjrginia (Wetzel CountY Hospital) - Hemangiopericytoma Wisconsin !Bellin Health) - Ocnna!Ofibrosarcoma protuberans Wisconsin (Mcritcr Hosojtall - Solitary fibrous tumor Wisconsin CPathology Ass9ciatesl - Soft tissue neoplasm, bemongloendothclioma ( l ); Spind!e cell hemnn&ioendothclioma (I) Ausrmli• <North Old Pathology Group) - Hcmangiopericytoma Ay<l!lllia <Royal Hoban Homita!l - Solitary fibrous tumor Austrllli• <Royal Prince Alfred Hospital) - Solitasy fibrous tumor Austm!ia <Sullivan Nicolllicks Pn!ltologyl - Solitasy fibrous tumor (bemangiopericytom:uous pancm) Gennany CUKE, Kermin.ujtut fur Pa!bologie) - Solitary fibrous tumor Ireland !Kmy Geneml Hospj!AI) - Solitary fibrous tumor Jamaica Clbe University of the West Indies) - HcmangiopericylonHI l3!lfl!l <Kvoto Univqsjty Hosnital) - Solilwy fibrous tumor )!!!!fiR CNagova Univcrsi!y School of Medicine) - Ocnnatofibrosan:oma protubcnlns New !gland (O!>go Di81!!!9Slic Lab) - Hcmangiopcricytoma Puerto Rico runi'!mity of Puerto Rjco School o(Medicine) - Hemangjopericytoma/solitary fibrous tumor Saudj Arabia OOn• fabad National Guard i'IO$!!itaJ) - Hemangiopericytoma Oalar O:!nmw! Medical Co1110rntionl - H""tmlnsJoendo!hclioma (4); l!~mangiopericy!amulsolit.ary fibrous 1umor (4)

Case 10 - Diagnosis: Hemangiopericytoma/solilary fibrous tumor, lower extremity

T-Y9220, M-90510

rnree!!)r's nolc: There is a trend to view lhese two diagnoses as a spectrum of the same tumor. (drc)

Case 10 - Reference." Goodlad JR and Fletcher CD. Soliwy Fibrous Tumor Arising in Unusual SitJ:s. Analysis of a Series. Hlstopatho/1991; 19(6):5 IS-

522 Wilkins GB and Rosai J. Solitasy fibrous Tumo< of the Mediastinum. Am fSurg PatluJI 1989; 13(7):547-557. YIIIIUiguehi T, Takimoto T, Yamashita T, et Pl. Fat-Containing Variant ofSolitwy Fibrous Tumor (Liporm~tous

HcmMgiopericytoma) Arising on Surface of Kidney. Uro/2005; 65(1 ):1 75. Camcsollc-Tcijeiro J, Lopes Manuel J, Vilanueva JP, ct al. Lipomatous Haemangiopcricytoma (Adipocytic Variant of Solitary

Fibrous Tumour) ofU>e Thyroid. Histopat1120Q3; 43(4):406-408. Espa1 NJ, Lewis JJ, Leung D. ct al. Conventional Hemangjopericytoma. Modem Analysis or OUtcome. Cancer 2~ 9S(8): 1746-

1751.

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