8/17/2019 Tugas Psikitari Haseo-Ela BAB OREXIN ANTAGONIST PARAGRAF DUA.docx

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Original Text:

Lack of orexins is associated with narcolepsy. Pharmacologic blockade of orexin receptors has been investigated not only as a novel hypnotic mechanism,but also for weight loss and to treat drug abuse. peci!cally, both the dualorexin receptor antagonists "#O$%s& for both orexin ' and ( receptors, andsingle orexin receptor antagonists "O$%'s and O$%(s&, selective either fororexin ' receptors or for orexin ( receptors, have been developed )*igure ''+(-and are being extensively tested at this time. #O$%s such as almorexant, +/012/2,and suvorexant "also known as 34+056& have preliminary evidence of e7cacy in the treatment of insomnia, and some are advancing in clinical trials,particularly suvorexant. Other #O$%s include 34+/51/, #O$% ', #O$% 6, and#O$% ((, ingle+action O$%s are also in development with O$%' agents "e.g.,+02/8, /8050(, 052'(0, 0'5((5& proving not to be particularlyrobust in treating insomnia, but with promising preliminary preclinical results forO$%( agents "e.g., 93P%, ;'510501&.

ハセヲの翻訳

 Translated Text "ambar ''+( - dan sedang diu=i secaraluas saat ini. #O$%s seperti almorexant, +/012/2, dan suvorexant "=ugadikenal sebagai 34+056& memiliki bukti awal keberhasilan dalam pengobataninsomnia, dan ada pula yang ma=u dalam u=i klinis, khususnya suvorexant.#O$%s lainnya termasuk 34+/51/, #O$% ', #O$% 6, dan #O$% ((, O$%s aksi

tunggal =uga dalam pengembangan dengan agen O$%' "misalnya, +02/8,

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/8050(, 052'(0, 0'5((5& membuktikan tidak secara khusus kuatdalam mengobati insomnia , tetapi dengan men=an=ikan hasil praklinis awaluntuk agen O$%( "misalnya, 93P%, ;'510501&.

)>ambar ''+((-

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)>ambar ''+((-

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