Tugas Pico
7
Nama : Wi dya Gita Y . NIM : 1011 02011 5. Regulation of human epithelial tight junction potein! "y #acto"acillu! plantaum in $i$o and potecti$e effect! o n the epithelial "a ie %"!tact #acto"acillu! plantaum& a commen!al "acteium of human!& ha! "een popo!ed to enhance the inte!tinal "aie& 'hich i! compomi!ed in a num"e of inte!tinal di!ode!. (o !tudy the effect of #. plantaum !tain W)* +1 on human "a i e functi on& hea lthy !u"ject ! 'e e admini !te ed #. pla nta um o pla ce"o in the duodenum fo , h "y mean! of a feeding cathe te . (he !caf fold p ot ei n -onul a occ luden ! / 1 and tan!mem"ane potein occludin 'ee found to "e !ignificantly incea!ed in the $icinity of the tightjunction (3 !tuctue!& 'hich fom the paacellula !eal "et'een cell! of the epithelium. In an in $ito model of the human epithelium& #. plantaum induced tan!location of /1 to the (3 egion4 ho'e$e& the effect! on occludin 'ee mino compaed 'ith tho!e !een in $i$o. #. plantaum 'a! !ho'n to acti$ate (olllie ecepto 2 (#R2 !ignal ing& and te atment of )ac o2 mon olay e! 'it h the (#R2 agon i!t 6am7)y !+89 6)+8 !igni ficant ly ince a!ed fluoe!ce nt !tai ning of occludi n in the (3. 6et eatme nt of )aco 2 monol aye! 'ith #. plantaum o 6)+8 !ignificantly attenuated the effect! of pho"ol e!teinduced di!location of /1 and occludin and the a!!ociated incea!e in epithelial pemea"ility. u e!ult! identifying commen!al "acteial !timulation of (#R2 in the gut epithelium a! a egulato of epithelial integity ha$e impotant implication! fo unde!tanding po"iotic mechani!m! and the contol of inte!tinal homeo!ta!i!. Statement of problem/i ssue:
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