SEMUA OBSTRUKSI

HIPERTENSI PORTAL

splenomegali

TROMBOSITTROMBOSIT

PERDARAHANPERDARAHAN

TEKANAN DARAH

TEKANAN DARAH

CURAH JANTUNG

ALDOSTERONALDOSTERON

ECVECV

VASODILATASIMALABSORBSI

OBSTRUKSI SINUSOID.PASCASINUSOID

, DAN PASCAHEPATIK

Kerusakan hati

FAKTOR PEMBEKUAN

HIPOALBUMINEMIA ASITES

ALDOSTERON

ECV

SEMUA OBSTRUKSI

VASODILATASI

VARISES

ENSEFALOPATI

SIRKULASI KOLATERAL PORTAL

HIPERTENSI PORTAL

RUPTUR

PERDARAHAN

Reabsorbed

Reticuloendothelial cells(macrophages, monocytes, etc)

Breakdown of erythrocytes

Hemoglobine

Hemo Globine

Iron Co Biliverdin Amino acids

Unconjugated bilirubin (soluble in fat)

Liver(hepatocytes)

Unconjugated bilirubin+

Glucuronic acid

Conjugated bilirubin (soluble in water)

Unconjugated bilirubin

Bile

Conjugated bilirubin

GI tract

Bacterial process

Urobilinogen

Within fecesPlasma

Unconjugated bilirubin+

Albumines(albumin-bilirubin complexes,

soluble in blood) Kidney