Obat yang mengandung Flavanoid

8/20/2019 Obat yang mengandung Flavanoid

1/13

TUGAS FARMAKOGNOSI II

SEDIAAN FARMASI ALKALOID

Oleh

ARVI AWALUDIN BAGUS SUSANTO

(15013143)

S1 FARMASI

SEKOLAH TINGGI TEKNOLOGI INDUSTRI DAN FARMASI BOGOR

FEBRUARI 201


2/13

A. ERGOTAMINE

BELLAPHEEN

K!"#!$%$%Bell&'!& !&l &l*&l!%'& 0+1",E-,!&"%e &--&e 0+3",

.he!/&-/%&l 20",

I'%*&$%

G&,,& &, '%&'&% 'e,& e-!$ e$%! '& -e$#!

&!!"% &, /e-le/%h& ,&,,& "e!#&$e 'e,& h!

6l&$he$+ /e-*e-%,& ,el%$&h '& %$!"%&+ ,&,,&

*&-'%!&$*le- 'e,& #&l#%&$%+ &h&-'%&+ e*&& #&'& '&'&

'& ,&,,& &$!"!!-+ G7I 'e,& h%#e-"!%l%+

h%#e-$e*-e$%+ e-!$e $!"&h+ '& '%&-e '%$el%,% *!$%#&$%

/e-,&%&+ $&*% *e#&l& /e-'e $e8&* &, /e-l&,9l&,

K!-& I'%*&$%

K&'&, %"/l "&% -&$& '& #&-e$he$%& l&% #&'& &,,!&

,e-&*+ #e,l%h&& *&/-+ #&l#%&$%+ "l *e-%,+ *e-%,&

/e-*-&,+ ,e-&*& $$ /e-*-&,+ -ee$% -%+ &h%&-'%&+

6l$h '& '-!8$%e$$

E6e* S&"#%,

.&'& :&, %'&* &'& %"#l$+ /-&'%*&-'%&+ 6%/-!$%$ *&#

:&,+ &!$%$+ e'e"&+ #e-/&h& E;G+ ,&,-e+ h%#!e$%+

%$*e"%&+ e*&& #-e*!-'%&l '& e-%+ &*%*&-'%&+

&$!$#&"$+e-%,!+,&&l9,&&l+"&l+ "&h+ $&*% !!+

#&-&e$%&+ le"&h+ 6%/-!$%$ #le-!#l"!&-%+ -&$& '%,% &,

/e-le/%h&

F&-"&*!l!,%

Be-'&$&-*& *!$e# /&h8& ,&,,& 6,$%!&l $e-%,

"el%/&*& h%#e-&*%6%&$ '&-% $%"#&%* '& #&-&$%"#&%*+

*!"/%&$% '% &&$ "e,h&$%l*& #-e#&-& * "e"#e-/&%*%

*e%'&* $e%"/&,& SSO7

A*%6%&$ ,&/,& &"#&* #&'& #e,,&& *!"/%&$%

e-,!&"%e '& L9&l*&l!%' Bell&'!&+ &, $e&-& $#e$%6%*

"e,h&"/& $%"#&%* '& #&-&$%"#&%*+ '%#e-*& !leh &*$%

$%e-,%$%* '&-% #he!/&-/%&l '&l&" "e,-&,% e6e* #$&

*!-%*!l+ #e-l '%#e-h&%*& /&h8& L9&l*&l!%' Bell&'!&

"e"%l%*% e6e* 6&-"&*!l!,% '& *&l%+ 'e,& *!"/%&$% &,

/%&$&F&-"&*!'% &"%* Me$%"l&$% "&# "e"/l!*%- -e$e#!- &l6&9&'-ee-,%* '&


3/13

$e-!!%e-,%*

D!$%$ Seh&-% 2 *&l% 192 '-&,ee

CAFERGOT TABLET

K!"#!$%$%E-,!&"%e &--&e 1 ",

;&66e%e 100 ",

I'%*&$%Se-&,& "%,-e+ $&*% *e#&l& &, /e-*&%& 'e,& %#e

#e"/lh '&-&h

K!-& I'%*&$%

G&,,& $%-*l&$% #e-%6e-+ #e&*% !/l%e-&%6 #e"/lh

'&-&h+ $&*% :&, *!-!e-+ h%#e-e$% /e-&+ ,&,,& 6,$%

,%:&l && h&%+ $e#$%$ (-e&*$% "" '%$e-&% 'e"&" *&-e&

*e,%&& /&*e-%+


4/13

maksimum dewasa sehari 6 tab atau seminggu 10 tab

B. OPIUM

LORDTAB 10

K!"#!$%$%Hydrocodone Bitartrate 10 mg

Acetaminophen 500 mg

I'%*&$% Me,h%l&,*& e-% $e'&, $&"#&% e-% *# #&-&h

K!-& I'%*&$%.&$%e 'e,& h%#e-$e$%%%&$ e-h&' h'-!!'!e &&

&e&"%!#he

E6e* S&"#%,

U""& e6e* $&"#%, L!-&/ &% "e,&* + *ee"&$& +

#$%,+ "&l + "&h + $&*% #e- + $e"/el% + $&*% *e#&l& +

#e-/&h& $&$&& h&% + #e,l%h&& *&/- + 'e-%, '% el%,&A'& + "l *e-%, + '& /e-#%*%- %'&* :el&$

F&-"&*!l!,%

H'-!!'!e &'&l&h &&l,e$%* &-*!%*& $e"%$%e%* '&

&%$%6 'e,& /e/e-& %'&*& *&l%&%6 "%-%# 'e,&

*!'e% 7 Se/&,%& /e$&- "el%/&*& $%$e" $&-&6 #$& '& !!

#!l!$ 7 Me*&%$"e &, e#& %'&*& '&-% h'-!!'!e '&

!#%& l&%& %'&* '%*e&h% + "e$*%# '%&*%% /e-h/,&

'e,& *e/e-&'&& -e$e#!- !#%& '% $%$e" $&-&6 #$& 7 Sel&%

&&l,e$%& + &-*!%*& '& "ee/&/*& "e,&* +

#e-/&h& $&$&& h&% '& *e*e-h& "e&l

F&-"&*!'%&"%* • Seel&h '!$%$ 10 ", !-&l h'-!!'!e '%/e-%*& *e#&'& $/:e*

l&*%9l&*% l%"& !-&, 'e8&$& + -&&9-&& #&* *!$e-&$%

&'&l&h 23+ ? 5+2 , = "L 7 %,*& $e-" "&*$%"" '%&%

#&'& 1+3 ? 0+3 :&" '& 8&* #&-h /e-e*&' * "e:&'% 3+@

? 0+3 :&" 7 H'-!!'!e "e:**& #!l& &, *!"#le*$

"e&/!l%$"e e-"&$* O 9 'e"ehl&%! + N'e"ehl&%! '&

#e,-&,& 9 *e! * &, $e$&% 9 & '& 9 /9 h%'-!*$%

"e&/!l%

• Ae&"%!#he e#& '%$e- '&-% $&l-& #ee-&& '&

'%'%$-%/$%*& *e $el-h :&-%,& /h 7 .l&$"& #&-h 1725

$&"#&% 3 :&"7 El%"%&$% &e&"%!#he !leh "e&/!l%$"e h&%

( *!:,&$% ) '& e*$*-e$% ,%:&l /e-%* "e&/!l%& 7 Se*%&-

@5 '&-% '!$%$ !-&l "l '&l&" -% '&l&" 8&* 24 :&"

&'"%%$-&$% + *e/&&*& $e/&,&% *!:,& ,l*-!%'& +


5/13

'e,& $e:"l&h *e%l *!:,& l&% '& !/& %'&* /e-/&h

D!$%$

D!$%$ l&


6/13

K!"/%&$% *!'e% 'e,& #&-&$e&"!l "e%,*&*& e6e*

&&l,e$%*&

F&-"&*!'%&"%*

;!'e% '%-e$!-#$% !-&l '& -e*&l 'e,& /&%*> '% '&l&" h&%


7/13

D!$%$De8&$& %*& $&*% 1 &/le+ /e-%*& 1 &/le $e% @ :&"+

"&*$%"" 4 &/le $eh&-%

SPASMAL

K!"#!$%$%

Meh&"#-!e 500 ",

E*$7 Bell&'!& 5 ",

.&e-%e Hl 30 ",

I'%*&$%

G&,,& $#&$%* (*e:&,) #&'& $&l-& #ee-&&+ $&l-&

*e"%h '& *el&"%+ $&l-& e"#e'7 D%$"e!-e (e-% #e-

#&'& $&& h&%')

K!-& I'%*&$%

Gl&*!"& $' e-#+ $"/&& $&l-& *e"%h '& $&l-&

#ee-&&+ &!% (%'&* &'&& e,&,& && *e*&& !!)$$+ %le$ #&-&l%%*"+ &$"&+ "%&$e%& ,-&%$+ *!l%%$

l$e-&%&+ he-%& h%&&l+ '& #e&*% $e-%$ h&% && ,%:&l

E6e* S&"#%,

Me%,*&*& e*&& '&l&" "&&+ $%*l!#e,%&+ "%'-%&$%$+ "l

*e-%,+ #&'&,& *&/-+ *e"e-&h& #&'& 8&:&h '& lehe-+

-ee$% '& he$%&$% -%+ &*h%*&-'%+ '&'& /e-'e/&-+

$e"/el%=$$&h /&, &%- /e$&-+ $h /h %,,%+ #e-&,$&,&

$$& $&-&6 #$&+ -&" *l%+ "&h+ '& 6!!6!/%&

F&-"&*!l!,%

Meh&"#-!e /e*e-:& $e/&,&% &&l,e$%*7+ '%&/$!-#$% '&-%

$&l-& #ee-&&+ "e"#&% 8&* #&-h 14 :&"7

.&e-% "e-#&*& -el&*$& ! $#e$%6%* &, /e*e-:& $e&-&

l&,$, #&'& !! #!l!$

F&-"&*!'%&"%*

Meh&"#-!e &'&l&h 'e-%& "e&$l6!& '&-% A"%'!#%-%&

&, /e*e-:& e-h&' $$& $&-&6 #$& &% "e,-&,%

$e$%%6%&$ -e$e#!- -&$& e-% '& "e"#e,&-h% #$&

#e,&-& $h /h7 T%,& e6e* &"& &'&l&h $e/&,&%

&&l,e$%*+ &%#%-e%*+ '& &%9%6l&"&$7 .&e-% '&

"e-el&*$&$% !! #!l!$ $e&-& l&,$, &, '& "e,h&"/&

6!$6!'%e$e-&$e

D!$%$De8&$& 192 &/+ 3 $eh&-%

A&* C &/+ 3 $eh&-%

D. PILOCARPIN

CENDO CARPIN 2%


8/13

K!"#!$%$% T% "l l&-& "e,&', .%l!&-#%e H;l 20 ",

I'%*&$%

.%l!&-#%e H;l &'&l&h &"%!% (#&-& $"#&!"%"e%)

'%,&*& * "e,e'&l%*& e*&& %-& !*l&-7 ,&

'& '%,&*& $e&-& *!"/%&$% 'e,& "%!%*9"%!%*

l&%&+ 9/l!*e-+%h%/%!- *&-/!%* &h%'-&$e+ $%"#&!"%"e%*

&& &,e h%#e-!$"!%*

K!-& I'%*&$%

• H%#e-$e$%%6 e-h&' $& && le/%h *&',& !/& %%

• T%'&* * '%,&*& '%"&& *!$-%*$% &, %'&* '%%,%*&+

$e#e-% #&'& %-%%$ &* '& #&'& "e-e*& &, "e:**&

h%#e-$e$%%%&$ e-h&' *!"#!e !/& '& #&'& #%l&-9

/l!* ,l&*!"&7

E6e* S&"#%,

L&*-%"&$%+ -&$& e-/&*&- && %'&* &"&+ $&*% *e#&l&

e"#!-e-+ $#e-6%$%&l *e-&%%$+ %l%&- $#&$"+ !:,%&l

&$l&- !,e$%! '& %'e' "!#%&7 E6e* $%$e"%* $e/&,%

/e-%* *&'&,e-:&'% 8&l&# $&,& :&-&, #&'& #&$%e &,

$e$%%6+ /e-*e-%,&+ &*%%&$ l&"/, &, /e-le/%h&7

Ke*e-h& #&'& le$& "&& ",*% e-:&'% #&'& #e,,&&

'&l&" 8&* &, l&"&7 .e-&h '%l!-*& e-:&'%& *&$$

-e%&l 'e&h"e #&'& #e,,&& "%!% &,e$

F&-"&*!l!,%

.%l!&-#%e &'&l&h $& hl!l%e-,% #&-&$"#&h!"%"e%

&, /e*e-:& $e&-& l&,$, "el&l% $%"l&$% e-h&'

-e$e#!- $&-&6 "$&-%% '& !! h&l$ $e#e-% %-%$ '&

*ele:&- $e*-e$%7 .%l!&-#%e "e,h&$%l*& "%!$%$ "el&l%

*!-&*$% #&'& %-%$ $#h%e-+ "ee//*& "e,*&& e*&&

#&'& $le-&l $#- '& "e"/*& -&, -&/el&- "e$h8!-*

&, "&& "e%"/l*& &l%-& *el&- #&'& &e!$ h"!-7De,& 'e"%*%& -e$%$e$% e-h&' &l%-& *el&- '%*-&,%+

$eh%,,& "e,h&$%l*& -& e*&& %-& !*l&-

F&-"&*!'%&"%* .e,,&& e-% #&'& ,l&*!"& .%l!*&-#% &'&l&h !/&

e-#%l%h '&l&" *e&'&& ,&8& &, '& "e-*& e*&&

/!l& "&& /&%*& ,l&*!"& /e-$' $e"#% ('%$e/ :,&

/e-$' e-#) "&# /e-$' le/&- (/e-$' e-/*&)7

O/& %% $&,& e6e*%6 * "e"/*& &&"& -&/e*l&-

'%$e*%&- *&&l Shle""+ $eh%,,& e*&& '&l&" /!l& "&&


9/13

- 'e,& $e,e-& &*%/& &%-& h"!- *el&- 'e,& l&&-7

Ke-:&& %% '& /e-l&,$, '&l&" $eh&-% '& '& '%l&,%

*e"/&l%7 O/& #ee*& *!l%e$e-&$e $e#e-% %$!6l-!& '&

e*!%!6&+ /e*e-:& le/%h l&"& l&,%

D!$%$ Tee$*& 192 ee$

EPICARPINE

K!"#!$%$% .%l!*&-#% H%'-!*l!-%'& 10 ",

I'%*&$%

.%l!*&-#% H;l &'&l&h &"%!%* (#&-&$%"#&!"%"e%*)

'%,&*& * "e,e'&l%*& e*&& %-&!*l&-+ :,&

'& '%,&*& $e&-& *!"/%&$% 'e,& "%!%*9"%!%*

l&%&+ /9/l!*e-+ %h%/%!- *&-/!%* &h%'-&$e+ $%"#&!"%"e%*

&& &,e h%#e-!$"!%*7

K!-& I'%*&$%

K!'%$% '%"&& *!$-%*$% ##%l&- %'&* '%%,%*&+ "%$&l&

-&'&, %-%$ &*+ &e-%!- e%%$+ '& #%ll&-9/l!*

,l&!"&7

H%#e-$e$%%%&$ e-h&' $&l&h $& *!"#!e !/&7

.e'e-%& &, "e,,&*& $!6 *!&* le$&7

E6e* S&"#%,

R&$& e-/&*&-+ ,&&l+ $&*%+ #e,l%h&& *&/-+ $% l%&-%

$#&$"$+ *!,e$% &$*l&- *!:,%&+ "e e/&/*&

"%!#%+ $e$%%$&$% *el!#&* "&& '& *!:,%&+

"e,-&,% *e&:&"& #e,l%h&& '&l&" #ee-&,& &,

le"&h+ *e*e-h& #&'& le$& "&& ",*% e-:&'% #&'&

#e,,&& '&l&" 8&* &, l&"&+ #e%,*&& ##%l&-%

/l!*+ *e-$&*& -e%& '& $&*% *e#&l& $e"e&-& &&

$#-&!-/%&l7

E6e* $%$e"%* $e/&,&% /e-%* *&'&, e-:&'% 8& l&#

$&,& :&-&, #&'& #&$%e &, $e$%%6 /e-*e-%,&+

&*%%&$ l&"/, /e-le/%h&

F&-"&*!l!,%

.%l!*&-#% &'&l&h !/& *!l%e-,%* (#&-&$%"#&!"%"e%*) &,

/e*e-:& l&,$, "ee/&/*& *!$-%*$% ##%l '& "e,-&,%

e*&& %-&!*l&-

F&-"&*!'%&"%* Absorpsi. Se&8& #%l!*&-#% /e-$%6& /&$& *& (


10/13

"e"&$*% SS.7 Distribusi. .%l!*&-#% /e-$%6& h%'-!6%l%*

$eh%,,& %'&* '& "ee"/$ e-e/-!9$#%&l /&--%e-

("e"/-&)7 Metabolisme. .%l!*&-#% e-%!%$&$% /&%*+

'%el%"%&$% '% he#&- '& l&,$, '%e*$*-e$%*& "el&l% ,%:&l7

Ekskresi. .%l!*&-#% h&"#%- %'&* '%'%6$% *e"/&l% $e&-& #&$%6

"el&l% "e"/-& $el *e '&l&" '&-&h '& l&,$, *el&-

'e,& &%- $e%

D!$%$ 2 ee$ (394 *&l% Seh&-%)

E. VINBLASTIN

VINBLASTIN VIAL

K!"#!$%$% D&l&" 10 "l %&l "e,&', V%/l&$% 10 ",

I'%*&$%

.e,!/&& l%"#h!"& H!',*% '& !9H!',*%+ *&-/%!"&

e$%$+ #&-+ *e#&l& '& lehe-+ #&'&-&+,%:&l7 F,%'e$

"!$%$+ $&-*!"& *!$%+ h%$%!$%!$%$+ *h!-%!*&-$%!"&+ '&

#-#-& -!"/!$%!#e%& %'%!#&%*

K!-& I'%*&$%

H&& * #e,,&& "el&l% I7V7+ #e"/e-%& "el&l%

%-&e*&l '& "ee/&/*& *e"&%&7 H%#e-$e$%%6%&$

e-h&' %/l&$%* && *!"#!e l&% '&l&" $e'%&&+

*eh&"%l&7

E6e* S&"#%,


11/13

SS. De#-e$%+ "&l&%$e+ $&*% *e#&l&+ $e% -% (J1 $e/&,&% !/& h)

F&-"&*!'%&"%*

V%/l&$% /e-%*&& #&'& /l% '& "e,h&"/& 6!-"&$%

"%*-!/l&+ *e"'%& "e&h& $el #&'& 6&$e "e&6&$e 'e,&

&-& "e,,&,, $#%'el "%!%* > $#e$%6%* * 6&$e M '& S7

V%/l&$% :,& "e"#e,&-h% &$&" *le& '& $%e$%$ #-!e%

'e,& "e"/l!* &$&" ,l&"& '& #e,,&&&7

D!$%$ A&*9&&* '& 'e8&$& I7V7 4920 ",=" (0719075 ",=*,) $e%

910 h&-% && 5 h&-% %6$ *!% '&-% 17592 ",="=h&-% &&

0719075 ",=*,="%,,7 .ee$&%& '!$%$ #&'& *e-$&*& h&%

Se-" /%l%-/% 1759370 ",='L && AST (SGOT) 091@0 %


12/13

Be-%*& 50 '&-% '!$%$ !-"&l7 Se-" /%l%-/% 3709570 ",='L

Be-%*& 25 '&-% '!$%$ !-"&l7 Se-" /%l%-/% 570 ",='L

&& AST 1@0 %

F. VINCRISTINE

VINCRISTINE VIAL

K!"#!$%$% T% 1"l "e,&', V%-%$%e 1 ",

I'%*&$%.e,!/&& le*e"%& &*+ l%"6!"& ,&&$+ #e&*% H!',*%+

e-h-&e"%& &* '& #&"el!$%$ &*

K!-& I'%*&$%

W&%& h&"%l+ #e"/e-%& %-&e*&l '& .&$%e 'e,& /e*

'e"%el%&$% $%'-!" ;h&-!9M&-%e9T!!h %'&* &*& '%/e-%

$%*& %-%$%e $l6&7

E6e* S&"#%,

Le*!#e%&+ -!"/!$%!#e%& -%,&+ &e"%&+ -!"/!$%!$%$

$e"e&-&

Ne-!!*$%$%&$+ #e-& -e6le*$+ #&-e$e$%& (,&,,&

#e-&$&& *l% $e#e-% *e$e"&)+ *!$%#&$%=$$&h /&, &%-

/e$&-+ *ele"&h& !!

M&l+ "&h+ *eh%l&,& &6$ "&*&+ '%&-e+ l$e-&$% !-&l

.!l%-%& (*e%, /&&*)+ '%$-%& (*e$l%& /&, &%- /e$&-+

&& $&*% $e8&* *e%,)+ -ee$% -%

H%#e-e$%+ h%#!e$%

Ke/!&*&

.e&*% ,%:&l &*%/& &$&" -& &*

Se$&* &6&$ /e-&"/&h #&-&h

F&-"&*!l!,% A*%%&$ &%"!- '&-% %*-%$% &'&l&h 'e,& #e,h&"/&&

"%!$%$ #&'& "e&6&$e "el&l% %e-&*$% 'e,& /l%7 Se#e-%

&l*&l!%' %& l&%&+ %*-%$% :,& '& "e,,&,, 1)

&$&" &"%!+ AM. $%*l%*+ '& "e&/!l%$"e ,l&h%!e+ 2) ;&2


13/13

9-&$#!- &*%%&$ AT.&$e *&l"!'l%9'e#e'e+ 3) -e$#%-&$%

$el+ '& 4) *le& &$&" '& l%#%' /%!$%e$%$

F&-"&*!'%&"%*

V%-%$%e &'&l&h &,e &%e!#l&$%* %& &l*&l!%' '%,&*&

$e/&,&% #e,!/&& * /e-/&,&% "&&" *&*e- e-"&$*

*&*e- #&'&-&+ #e&*% H!',*%+ $&-*!"& K!$%+ '&

*&*e- e$%$7 Al*&l!%' %& $e&-& $-*-&l $e&8& "%-%#

e-'%-% '&-% 2 "l%-%,e' %+ %'!l%e '&

*&&-&%7 Al*&l!%' %& "e:&'% /e-,& $e&-& *l%%$ $e:&*

#ee"& $%6& &%"!- "e-e*& #&'& &h 157 A8&l&+

e*$-&* '&-% &&"& &* '&-& (;&h&-&h$ -!$e$) '%$el%'%*%

*&-e& $%6& h%#!,l%*e"%* '%',&+ e% e-&& "ee/&/*&

#ee*&& $"$" #&'& %*$ '& e6e* &%le*e"% %

%-! 7 V%-%$%e "e,%*& #-!e% "%*-!/l&- '&-% ,ele'!,

"%!$%$+ &, "e,&-&h *e *-%$&l%$&$% '&-% "%*-!/l$ '&

#e&,*& "%!$%$ && *e"&%& $el7V%-%$%e "e"%l%*%

/e/e-& e6e* %"!$#-e$&7 Al*&l!%' %& '%&,, $%*l$

$el 6&$e $#e$%6%*7

D!$%$

I6$ %-&e& (IV) $%,*& && /!l$

De8&$& 1+4 ",="2 ("&*$%"" 2 ",) % "%,,

A&*9&&* 2 ",="2

A&*9&&* 'e,& /e-& /&'& 10 *, && *-&, '!$%$

'%"l&% 0+05 ",=*, /e-& /&'& $e*&l% $e"%,,

Obat yang mengandung Flavanoid

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