Golongan obat kuinolin

8/18/2019 Golongan obat kuinolin

1/9

(GOLONGAN OBAT YANG DIDAPATKAN)

GOLONGAN KUINOLIN

No.

Nama obat

FarmakokinetikaLipofi

lita

Onet D!rai T "#$ BaIkatan

proteinAborbai %etabolime &kkrei '

".Amoia!i

ne

*.$ + ".,

(ran-e

./ to

*.*)

min!te

0apil1 aborbe

follo2in- oral

aminitration

Amoia!ine i

rapil1

3on4erte in t5e

li4er

to t5e a3ti4e

metabolite

eet51lamoia

!ine

e63rete

!n35an-e in t5e

!rine

itrib!tion(')

i maller (", to

7/ L#k-)

$. !inine 35ilren8

9:"$ 5r;

a!lt8


2/9

!inine i

e63rete

!n35an-e in

!rine.

L#k- E5ealt51

!bHe3t 25o

re3ei4e a

in-le oral

9 m- oe

7. !iniine Onet8 PO8

":7 5r

9:< 5r 9:< 5r # 9

5r

Oral

bioa4ailab

ilit1

Almot

3omplete

aborption


3/9

t5e plama

i bo!n

to

noniff!i

ble plama3ontit!en

t

-atrointetinal

tra3t

!ite lo2@

b!t i

in3reae b1

a3iifi3ation

of t5e !rine.• !rine (,>

a !n35an-e

r!-);

a3iifi3ation

of !rine

in3reae

elimination

""9:$

=

Jell aborbe

from t5e

-atrointetinal

tra3t. T5e

preen3e of foo

i-nifi3antl1

en5an3e t5e

rate an e6tent

of aborption.

Metabolism

&6teni4el1

metabolie in

li4er b1

YP7A/

%etabolite8

$@


4/9

,. ?alofantrin

e

9:"

a1

9:,>; ?epati3

?alofantrine

1to35rome

P/* 7A/ N:eb!t1l5alofantr

ine

http://www.drugbank.ca/biodb/bio_entities/BE0002638http://www.drugbank.ca/biodb/bio_entities/BE0002638http://www.drugbank.ca/metabolites/DBMET00371http://www.drugbank.ca/metabolites/DBMET00371http://www.drugbank.ca/metabolites/DBMET00371http://www.drugbank.ca/metabolites/DBMET00371http://www.drugbank.ca/metabolites/DBMET00371http://www.drugbank.ca/metabolites/DBMET00371http://www.drugbank.ca/biodb/bio_entities/BE0002638http://www.drugbank.ca/biodb/bio_entities/BE0002638


5/9

No Nama obat Uk.molek!l Koefi

ien

partii

Pka P5 tr!kt!r pentin- Kation#anion Bent!k

molek!l# ionMat

aktif

eiaan

". Amoia!ine 355.86118

g/mol

pKa (tron-et

Bai3) ".$7

pKa (tron-et

A3ii3) =."$

C20H22ClN3O

$. !inine 324.41676

g/mol pKa (tron-et

A3ii3) "7.


6/9

/. prima!ine 259.34674

g/mol

pKa (tron-et

A3ii3) ",.""

pKa (tron-et

Bai3) ".$

C15H21N3O

*. Chloroquine 319.87214

g/mol

pKa "."

pKa (tron-et

Bai3) ".7$

C18H26ClN3

https://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C15H21N3O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C15H21N3O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C15H21N3O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C15H21N3O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C15H21N3O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C15H21N3O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C15H21N3O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C18H26ClN3&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C18H26ClN3&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C18H26ClN3&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C18H26ClN3&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C18H26ClN3&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C18H26ClN3&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C15H21N3O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C18H26ClN3&sort=mw&sort_dir=asc


7/9

9. %eflo!ine 378.312159

g/mol pKa (tron-et

A3ii3) "7.,=

pKa (tron-et

Bai3) =./9

Anion an

kation

C17H16F6N2O

,. ?alofantrin 500.42371

g/mol pKa (Strongest

Acidic) 14.47

pKa (Strongest

Basic) 10.05

C26H30Cl2F3NO

https://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C17H16F6N2O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C17H16F6N2O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C17H16F6N2O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C17H16F6N2O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C17H16F6N2O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C17H16F6N2O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C17H16F6N2O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C17H16F6N2O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C17H16F6N2O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C26H30Cl2F3NO&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C26H30Cl2F3NO&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C26H30Cl2F3NO&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C26H30Cl2F3NO&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C26H30Cl2F3NO&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C26H30Cl2F3NO&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C26H30Cl2F3NO&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C26H30Cl2F3NO&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C26H30Cl2F3NO&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C17H16F6N2O&sort=mw&sort_dir=aschttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C26H30Cl2F3NO&sort=mw&sort_dir=asc


8/9

Martindale edisi 36 Antimalarials/Amodiaquine 597

5ttp8##referen3e.me3ape.3om#r!-#!ala!in:!inine:7/$9=9"

5ttp8##referen3e.me3ape.3om#r!-#!ina-l!te:!inie6:!iniine:7/$7


9/9

5ttp8##p!b35em.n3bi.nlm.ni5.-o4#3ompo!n#$"9*

5ttp8##p!b35em.n3bi.nlm.ni5.-o4#3ompo!n#/9=$e3tionTop

5ttp8##p!b35em.n3bi.nlm.ni5.-o4#3ompo!n#7,7=7

5ttp8##222.r!-bank.3a#r!-#DB"$"

Golongan obat kuinolin

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