Farmakologi Obat-obat Yang Bekerja Pada Kulit

8/10/2019 Farmakologi Obat-obat Yang Bekerja Pada Kulit

1/23

FARMAKOLOGI OBAT-

OBAT YANG BEKERJA

PADA KULIT

dr. Rohmania Seiarini


2/23

Farma!o!inei!

Na"i# o#a di da$am %#%h

A#"or&"i

Di"ri#%"i Mea#o$i"me

E$imina"i

Farma!odinami!E'e! o#a erhada& %#%h

Tera&i

To!"i!

De'ini"i


3/23

Farma!o!inei! ( Farma!odinami!

McLeod, HL, et. al. Peds Rev. 1992;13:413-421


4/23

Basics of Dermatological Therapy

Medi)a$ hera&* in Dermao$o+* )on"i"" o',

o&i)a$

"*"emi)

&hoohera&*and

"%r+i)a$ &ro)ed%re"
http://sprojects.mmi.mcgill.ca/dermatology/therapy.htmhttp://sprojects.mmi.mcgill.ca/dermatology/therapy.htmhttp://sprojects.mmi.mcgill.ca/dermatology/therapy.htmhttp://sprojects.mmi.mcgill.ca/dermatology/therapy.htmhttp://sprojects.mmi.mcgill.ca/dermatology/therapy.htmhttp://sprojects.mmi.mcgill.ca/dermatology/therapy.htmhttp://sprojects.mmi.mcgill.ca/dermatology/therapy.htmhttp://sprojects.mmi.mcgill.ca/dermatology/therapy.htm


5/23

Topical TherapyThe adana+e o' dire) de$ier* and red%)ed "*"emi)

oi)i* ma!e o&i)a$ reamen /%ie ara)ie. There i"

o'en a ehi)$e 0hi)h hen )onain" an a)ie in+redien.


6/23

Vehicles include:

Cream a semi-solid emulsion of oil-in-water; contains apreservative to prevent overgrowth of micro-organisms. ta!ili"e

!y an emulsifier. #ostly water so mostly evaporates; non-greasy s

easy application and removal.

$el a semi-solid transparent non-greasy emulsion.

%otion li&uid vehicle' a&ueous or alcohol !ased' which may

contain a salt in solution. Calamine lotion is a shake lotionwhichcontains an insolu!le powder. %otions evaporate to cool the

inflamed(e)udative s*in.


7/23

+intment1 a "emi-"o$id +rea"e2oi$3 "omeime" a$"o)onainin+ &o0der3 #% $i$e or no 0aer. The a)ie

in+redien i" "%"&ended. U"%a$$*3 no &re"eraieneeded. Oinmen" are #e" "%ied 'or dr* "!in di"order"

1 reh*drae and o))$%de. Be)a%"e he* are +rea"*3 he*

are di''i)%$ o remoe.

,aste1 An oinmen 0ih a hi+h &ro&orion o' &o0der0hi)h +ie" a "i'' )on"i"en)*. Pa"e" )an #e a&&$ied o0e$$-demar)aed $e"ion". D%e o i" oinmen #a"e3 he*

are di''i)%$ o remoe.


8/23

mollientsEmo$$ien" are %"e'%$ in dr*-"!in di"order" d%e o heir

a#i$i* o re-e"a#$i"h he "%r'a)e $i&id $a*er and

enhan)in+ reh*draion o' he e&idermi". There are

"eera$ emo$$ien oinmen"3 )ream" and oi$" added o

#ah".


9/23

Overview of Topical Medications

Drug Pharmacology Indications

Antibiotics Resistance and sensitization areotential roble!s. "acitracin,c#lortetrac$cline, %ra!icidin,!&irocin, neo!$cin, ol$!i'in,sodi&! (&sidate. Metronidazole

is &sed (or rosacea.

Acne, (ollic&litis,i!eti%o, in(ectedecze!a, rosacea.

Anti(&n%als A!orol(ine, clotri!azole,econazole, )etoconazole,!iconazole, n$statin, terbina(ine,

s&lconazole.

*&n%al in(ection o( t#es)in, +andidiasis.


10/23

Antisetics +#lor#e'idine, iodineco!o&nds, otassi&!er!an%anate, silver nitrate.

)in sesis, le%&lcers.

Antivirals do'&ridine, ac$clovir. Heres si!le' andzoster.

+oal tar Pres&!ed anti-in(la!!ator$

and anti-roli(erative e((ects.

cze!a, soriasis.

+orticosteroids Anti-in(la!!ator$, anti-roli(erative,vasoconstrictive; di((erentstren%t#s available.

cze!a, discoid l&&ser$t#e!atos&s, lic#enlan&s, lic#enscleros&s, !$cosis

(&n%oides,#otoder!atoses,it$riasis rosea,soriasis.


11/23

/it#ranol Anti-roli(erative Psoriasis.

0ita!in /analo%&es

n#ibit )eratinoc$teroli(eration andro!ote di((erentiation.+alciotriol, tacalcitol.

Psoriasis.

eratol$tics alic$lic acid, benzo$lero'ide, tretinoin. Acne, scal$ecze!as.

Parasiticidals Malat#ion, er!et#rin,carbar$l (or lice. "enz$lbenzoate, lindane,!alat#ion, er!et#rin(or scabies.

Lice, scabies.


12/23

teroid Topical

Class

4er* &oen 5%& o 677 ime" a" &oen a" h*dro)ori"one89$o#ea"o$ &ro&ionae

Beameha"one di&ro&ionae


13/23

Class /Poen 5I:7-;77 ime" a" &oen a" h*dro)ori"one8

Beameha"one a$erae

Beameha"one di&ro&ionae

Di'$%)oro$one a$eraeF$%i)a"one a$erae


14/23

Class 0Moderae5>->: ime" a" &oen a" h*dro)ori"one8

A)$omea"one di&ro&ionae9$o#ea"one #%*rae

F$%o)ino$one a)eonide

Triam)ino$one a)eonide

Class 1Mi$d


15/23

*in a!sorption of topical steroidsSeroid" are a#"or#ed a di''eren rae" 'rom di''eren &ar"

o' he #od*. A "eroid ha 0or!" on he 'a)e ma* no 0or!on he &a$m. B% a &oen "eroid ma* )a%"e "ide e''e)" on

he 'a)e.

For eam&$e,

Forearm a#"or#" ;?Arm&i a#"or#" @?

Fa)e a#"or#" =?

E*e$id" and +enia$" a#"or# 7?

Pa$m a#"or#" 7.;?

So$e a#"or#" 7.7:?


16/23

*in side effects

Lo)a$ "ide e''e)" o' o&i)a$ "eroid" in)$%de,

S!in hinnin+ 5aro&h*8 and "re)h mar!" 5"riae8.Ea"* #r%i"in+ and earin+ o' he "!in.Periora$ dermaii"5ra"h aro%nd he mo%h8.

En$ar+ed #$ood e""e$" 5e$an+ie)a"ia8.S%")e&i#i$i* o "!in in'e)ion".In'e)ion e.+. ineain)o+nio.A$$er+* o he "eroid )ream.
http://dermnetnz.org/dermal-infiltrative/striae.htmlhttp://dermnetnz.org/fungal/tinea-incognito.htmlhttp://dermnetnz.org/fungal/tinea-incognito.htmlhttp://dermnetnz.org/fungal/tinea-incognito.htmlhttp://dermnetnz.org/fungal/tinea-incognito.htmlhttp://dermnetnz.org/dermal-infiltrative/striae.html


17/23

Br%i"in+S!in hinnin+

Prominen )a&i$$arie"Sre)h mar!"


18/23

ystemic Therapy

S*"emi) hera&* i" re"ered 'or more "erio%"

)ondiion and in'e)ion".


19/23

Overview of Systemic Therapy

Group Drug Indications

Antiandro%ens +$roterone Acne onl$ in (e!ales

Antibiotics 0ario&s Acne, rosacea, s)insesis

Anti(&n%als 5riseo(&lvinetoconazoletraconazole6erbina(ine

*&n%al n(ection*&n%al n(ect.,+andidiasis*&n%al n(ect.,+andidiasis*&n%al n(ection

Anti#ista!ines H1 "loc)ers cze!a, &rticaria


20/23

Antilerotic /asone /er!atitis#ereti(or!is, leros$,vasc&litis

Anti!alarials H$dro'$c#loro7&ine L&&s er$t#e!atos&s,ro#$ria c&taneatarda

Antivirals Ac$clovir*a!ciclovir

Heres si!le'8zosterHeres zoster, %enital#eres si!le'

+orticosteroids Prednisolone &s&all$ "&llo&s disorders,connective tiss&edisease, vasc&litis

+$toto'ics Met#otre'ateH$dro'$&rea

Azat#iorine

Psoriasis, sarcoidosisPsoriasis"&llo&s disorders,c#ronic actinicder!atitis


21/23

!!&nos&ressant +$closorin

5old

Psoriasis, atoic

ecze!a"&llo&sdisorders, l&&ser$t#e!atos&s

Retinoids Acitretinsotretinoin

eratinizationdisordersAcne


22/23

,hototherapyU4A

U4BPU4A

PU4B


23/23

Terima 2asih

Farmakologi Obat-obat Yang Bekerja Pada Kulit

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