Dengue

Billy ThionatanAgustian Firmansyah

Pembimbing:Dr. Didi Candradikusuma, Sp.PD

Epidemiologi

Genom DENV terdiri dari 11.644 nukleotida dan tersusun dari 3

protein struktural yaitu core protein (C), membran (M), dan

envelope (E) serta 7 protein nonstruktural

Genom DENV terdiri dari 11.644 nukleotida dan tersusun dari 3

protein struktural yaitu core protein (C), membran (M), dan

envelope (E) serta 7 protein nonstruktural

Memiliki 4 serotipe virus(Den-1, Den-2, Den-3, Den-4)

Memiliki 4 serotipe virus(Den-1, Den-2, Den-3, Den-4)

VIRUS DENGUE

Dengue virus merupakan genus Flavivirus dan family FlaviviridaeDengue virus merupakan genus Flavivirus dan family Flaviviridae

Penempelan Virus

Fusi Virus

Translasi

Replikasi

1

2

3

4

7

6

5

Rilis virus

Maturasi

Budding

Manifestasi Klinis

CLNICAL

COURSE

Laboratory Diagnosis

• Complete Blood Counts• Hematocrit• Platelet Count• Serum SGOT, SGPT• Immunological Tests (IgM & IgG

Anti Dengue, Ns1)

Pathophysiology Transmitted by the bite

of Aedes mosquito (Aedes aegypti)

Incubation 3-14 days Acute illness and

viremia 3-7 days

Pathophysiology Dengue virus enters and replicates within

monocytes, mast cells, fibroblasts Innate and adaptive immune response Cytokine release: TNF-a, IL-2, IL-6, IL-8 Compliment activation Antibody dependent enhancement (ADE) thought to

contribute to severe infections T-cell activation: CD4 and CD8 cells cytokine

production

Pathophysiology

Treatment

No specific therapy Bed rest Supportive measures: adequate hydration antipiretic (if needed)

Management of DHF/DSS

• Close monitoring of hypotension/shock• Oxygen administration• IV. Infusion of crystalloids/colloids• Platelet transfusion• Clotting factors replacement• Case fatality is 5% in good centers

Kriteria KRS

Warning Sign